Medicine and Health Sciences Commons^™

Super-Enhanced Marco Variant Drives Triple-Negative Breast Cancer Progression, Weei-Chin Lin, Fang-Tsyr Lin

Faculty, Staff and Students Publications

No abstract provided.

Comparison Of Supine And Vertical Bioimpedance Measurements In Young Adults, Jeremy B. Ducharme, Chloe Clark, Jonathan M. Houck, Holly Hall, Avadney Gerard-Osbourne, Ann Gibson

Topics in Exercise Science and Kinesiology

Topics in Exercise Science and Kinesiology Volume 3: Issue 1, Article 11, 2022. Bioelectrical impedance analysis (BIA) methods estimate health parameters such as phase angle (PhA) and body fat percentage (%BF) from various positional and electrode configurations. PhA and %BF are known biological markers of cellular and physical health, respectively, and can be used to predict various health-related conditions and therefore require accurate assessment. The purpose of this study was to evaluate the effect of body position during BIA by investigating the difference and agreement between PhA and %BF using RJL (supine) and InBody (vertical) analyzers. Thirty-eight young adults (23.4 …

2022-12-12_Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services

Michigan COVID-19 Hospital Data

Contains the tables Statewide Hospital Capacity Report for COVID-19, COVID-19 Metrics, Statewide Hospital Available PPE Tracking for COVID-19, as well as the tables PPE Days On Hand and Patient Census.

Ada News - 12/12/2022, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

A Comparison Of Therapeutic Regimens In The Treatment Of Hypothyroidism, Christina M. Cranley, Justin Gambini

Doctor of Medical Science (DMSc)

Hypothyroidism is a chronic medical condition that results in the inadequate production of thyroid hormones. Thyroid hormones are essential for the metabolism of almost every organ in the body. The prominent symptoms of hypothyroidism include lack of energy, weight gain, constipation, and intolerance to cold temperatures. Medical therapies aim to replenish thyroid hormones enough to meet the body's metabolic demands. Unfortunately, many individuals experience persistent symptoms despite stable thyroid hormone levels. Current treatment options for hypothyroidism include Levothyroxine, Liothyronine, and Desiccated Thyroid Extract (DTE). Levothyroxine contains synthetic T4 and is the current gold-standard medical therapy in hypothyroid patients. Liothyronine, synthetic …

Intouch Week Of December 12, 2022, New York Medical College

InTouch

• Touro University Marks 50 Years at Celebratory Gala
• Department of Pathology, Microbiology and Immunology Hosts Inaugural Research Symposium
• NYMC Café Re-opens for Business
• StuHe Hosts Career Networking and Mock Interview Event
• NYMC Examines Disparate Access to Breast Cancer Screening and Treatment for Low-Income Communities
• NYMC and TU Present 23rd COVID-19 Symposium

2022-12-12_Michiganoverview_Covidoutbreak, Michigan Department Of Health & Human Services

Michigan COVID-19 Outbreak Reports

The Outbreak Data page was obtained from Michigan's COVID-19 data page: https://www.michigan.gov/coronavirus/stats/outbreak-reporting.

This report is created by the Michigan Department of Health & Human Services from data self-reported by local health departments. Data is updated every week.

COVID-19 outbreaks are generally defined as two or more cases with a link by place and time indicating a shared exposure outside of a household. Local health departments report the number of new and ongoing outbreaks they are investigating by the setting of the outbreak. New outbreaks are those outbreaks that were first identified during the current reporting week. Ongoing outbreaks are …

Creation Of Preschool Evaluation For Children Experiencing Sensory Processing Disorders, Mary Vestal

Honors Theses

For our thesis project, we partnered with Dr. Michelle Suarez, the co-director of the Resiliency Center at Western Michigan University. When we first met with her, she informed us about the high rates of expulsion for Kalamazoo preschool students with various regulation challenges relating to sensory processing disorders, regulation, autism, and trauma. In fact, according to the U.S. Department of Health and Human Services, preschool students are expelled at three times the rate of children in K-12 (2022). Additionally, according to the Equal Justice Society, 250 preschool children get suspended or expelled each day nationwide (2021). The article continues to …

Analisis Faktor Risiko Keluhan Fatigue Pada Pramudi Brt (Bus Rapid Transit) Transjakarta Tahun 2022, Stefany Avelliana Megaranti, Chandra Satrya

National Journal of Occupational Health and Safety

There were 508 cases of Transjakarta Bus accidents in 2021. Investigation results by the National Transportation Safety Committee (KNKT) revealed that one of the causes was driver fatigue. This study aims to describe fatigue complaints and analyze fatigue-related risk factors in Drivers of Transjakarta BRT (Bus Rapid Transit) and Non-BRT in 2022. This research is a quantitative study with an analytical descriptive research design. The research sample was 124 Drivers of Transjakarta BRT and Non-BRT. The independent variables in this study are work-related risk factors (Work Duration, Shift Work, Rest Time, Commuting Time, and Workload). The covariates in this study …

Gambaran Faktor Psikososial Dan Distress Pada Guru Sekolah Luar Biasa (Slb) Di Kota Depok Saat Pandemi Covid-19 Tahun 2022, Azka Hafia, Dadan Erwandi

National Journal of Occupational Health and Safety

This study aims to obtain an overview of psychosocial factors and distress among special education teachers in Depok during the COVID-19 pandemic in 2022. This study used a cross-sectional study design with a semi-quantitative approach through filling out questionnaires and interviews. A total of 67 special education teachers in Depok participated in this study. The results showed that 34.3% of teachers experienced moderate distress, and 16.4% of teachers experienced significant distress. Then, it was found that distress is more experienced by female teachers (52.7%), aged > 30 years (52.4%), came from non-PLB study programs (52.5%), did not have personality type A …

Analisis Stres Kerja Pada Pengemudi Truk Pengantar Produk Pt Xyz Tahun 2022, Riska Oktaviana, Hendra Hendra

National Journal of Occupational Health and Safety

Drivers are one of the occupational groups with the highest risk of experiencing workplace stress. This can happen to truck drivers who play an important role in the PT XYZ product delivery process. This study aims to describe the work stress level in PT XYZ product delivery truck drivers and the risk factors associated with work stress. The factors studied include individual factors (age, marital status, place of residence, number of children, and length of service), psychosocial factors related to job context (job control, social support, and home-work interface), and job content (physical environment of the cabin, workload, and working …

The Hypertension Cascade Of Care In The Midst Of Conflict: The Case Of The Gaza Strip, Bassam A. Abu Hamad, Zeina Jamaluddine, Gloria Safadi, Marie Elizabeth Ragi, Raeda El Sayed Ahmad, Eszter P. Vamos, Sanjay Basu, John S. Yudkin, Mohammed Jawad, Christopher Millett, Hala Ghattas Ph.D.

Faculty Publications

Although hypertension constitutes a substantial burden in conflict-affected areas, little is known about its prevalence, control, and management in Gaza. This study aims to estimate the prevalence and correlates of hypertension, its diagnosis and control among adults in Gaza. We conducted a representative, cross-sectional, anonymous, household survey of 4576 persons older than 40 years in Gaza in mid-2020. Data were collected through face-to-face interviews, anthropometric, and blood pressure measurements. Hypertension was defined in anyone with an average systolic blood pressure ≥140 mmHg or average diastolic blood pressure ≥90 mmHg from two consecutive readings or a hypertension diagnosis. The mean age …

Contextualising The Pillars Of Household Food Security: Evidence From Iringa District, Tanzania, Tiemo Romward Haule

Journal of Humanities and Social Sciences

This paper contextualises the pillars of food security based on the perceptions of local communities in Iringa district, Tanzania. The pillars are food availability, food accessibility, food affordability, food adequacy, food acceptability and food stability. The study involved 376 participants. Structured interviews, field observation, focused group discussions, in depth interviews and documentary review were the methods used for data collection. Findings reveal that many households (76.2%) in Iringa were facing food shortage. The findings show that food insecurity in the district was exacerbated by the lack of steadiness in the six pillars of household food security. Given its semi-arid climatic …

Total Hip Arthroplasty In Patients With Neurological Conditions: A Systematic Review, Conor S O'Driscoll, Andrew J Hughes, Martin S Davey, Joseph M Queally, Brendan J O'Daly

Rothman Institute Papers

Background: As operative techniques and implant design have evolved over time, total hip arthroplasty (THA) is increasingly being carried out for patients with neurological impairment. This patient group places unique surgical challenges to the arthroplasty surgeon, which may include contractures, instability, and altered muscular tone. The purpose of this systematic review is to report the patient outcomes, complications, and implant survival following THA for patients with neurological conditions affecting the hip. Thus, we aim to support orthopaedic surgeon decision-making when considering and planning THA for these patients.

Methods: A systematic review was performed as per Preferred Reporting Items for Systematic …

Understanding The Experiences Of African American Caregivers Of Loved Ones With Dementia, Paula R. Madison

Seton Hall University Dissertations and Theses (ETDs)

Background: Dementia is a public health problem that is estimated to triple by 2050.Globally, dementia is the seventh leading cause of death among all diseases and one of the major causes of disability and dependency among older people. The direct medical costs and indirect social and economic costs of dementia are burdensome to society, and by 2030 it is projected to cost more than $2.8 TRILLION dollars worldwide. African Americans are two to four times more likely to be diagnosed with dementia than White Americans; and more likely to rely on informal care from family and friends. African …

Clinical Characteristics And Electrophysiologic Properties Of Scn5a Variants In Fever-Induced Brugada Syndrome, Gan-Xiao Chen, Hector Barajas-Martinez, Giuseppe Ciconte, Cheng-I Wu, Michelle M Monasky, Hao Xia, Bian Li, John A Capra, Kai Guo, Zhong-He Zhang, Xiu Chen, Bo Yang, Hong Jiang, Gary Tse, Chloe Miu Mak, Yoshiyasu Aizawa, Michael H Gollob, Charles Antzelevitch, Arthur A M Wilde, Carlo Pappone, Dan Hu

Division of Cardiology Faculty Papers

Background: Brugada syndrome (BrS) is a severe inherited arrhythmia syndrome that can be unmasked by fever.

Methods: A multicentre clinical analysis was performed in 261 patients diagnosed with fever-induced BrS, including 198 (75.9%) and 27 (10.3%) patients who received next-generation genetic sequencing and epicardial arrhythmogenic substrate (AS) mapping, respectively.

Findings: In fever-induced BrS patients, pathogenic or likely pathogenic (P/LP) SCN5A variant carriers developed fever-induced BrS at a younger age, and more often in females and those of Caucasian descent. They exhibited significant electrophysical abnormalities, including a larger epicardial AS area, and more prolonged abnormal epicardial electrograms. During a median follow-up …

An Imaging Mass Spectrometry Investigation Into The N-Linked Glycosylation Landscape Of Pancreatic Ductal Adenocarcinoma And The Development Of Associated Tools For Enhanced Glycan Separation And Characterization, Colin Mcdowell

MUSC Theses and Dissertations

The severity of pancreatic ductal adenocarcinoma (PDAC) is largely attributed to a failure to detect the disease before metastatic spread has occurred. CA19-9, a carbohydrate biomarker, is used clinically to surveille disease progression, but due to specificity challenges is not suitable for early discovery. As CA19-9 and other prospective markers are glycan epitopes, there is great clinical interest in understanding the glycobiology of pancreatic cancer. Unfortunately, few studies have been able to link glycosylation changes directly to pancreatic tumors and instead have focused on peripheral glycan alterations in the serum of PDAC patients. To address this gap in our understanding, …

The Geriatric Emergency Department At The University Of California San Francisco: Structures, Roles, And Lessons Learned, Todd James

Journal of Geriatric Emergency Medicine

No abstract provided.

Efficacy And Safety Of Fecal Microbiota Transplantation In Treatment Of Clostridioides Difficile Infection Among Pediatric Patients: A Systematic Review And Meta-Analysis, Kyaw Min Tun, Mark Hsu, Kavita Batra, Chun-Han Lo, Tooba Laeeq, Tahne Vongsavath, Salman Mohammed, Annie S. Hong Md

Department of Internal Medicine Faculty Research

Background and Aims: Cases of Clostridioides difficile infection have been rising among the pediatric and adolescent population. Fecal microbiota transplantation (FMT) has emerged as an alternative therapy for recurrent C. difficile infection. We aim to perform the first systematic review and meta-analysis investigating the safety and efficacy of fecal microbiota transplantation for C. difficile infection in children and adolescents. Methods: A literature search was performed using variations of the keywords “pediatrics”, “C. difficile infection”, and “fecal microbiota transplantation” in PubMed, EMBASE, CINAHL, Cochrane, and Google Scholar from inception to 30 June 2022. The resulting 575 articles were independently screened by …

Pre-Existing Diabetes Mellitus, Hypertension And Kidneydisease As Risk Factors Of Pre-Eclampsia: A Disease Of Theories And Its Association With Genetic Polymorphism, Abdullah Salah Alanazi, Francis Victor, Kanwal Rehman, Yusra Habib Khan, Ismaeel Yunusa Ph.D., Abdulaziz Alzarea, Muhammad Sajid Hamid Akash, Tauqeer Hussain Mallhi

Faculty Publications

Pre-existing diabetes, hypertension and kidney disorders are prominent risk factors of pre-eclampsia (PE). It is a multifactorial pregnancy disorder associated with high blood pressure, proteinuria, and multiorgan failure, which develops after the 20th week of pregnancy. It is one of the most feared pregnancy disorders, as it consumes thousands of fetomaternal lives per annum. According to clinical and pathological studies, the placenta appears to be a key player in the pathogenesis of PE; however, the exact origin of this disorder is still under debate. Defective placentation and angiogenesis are the hallmarks of PE progression. This angiogenic imbalance, together with maternal …

Issues In Melanoma Detection: Semisupervised Deep Learning Algorithm Development Via A Combination Of Human And Artificial Intelligence, Xinyuan Zhang, Ziqian Xie, Yang Xiang, Imran Baig, Mena Kozman, Carly Stender, Luca Giancardo, Cui Tao

Faculty, Staff and Student Publications

BACKGROUND: Automatic skin lesion recognition has shown to be effective in increasing access to reliable dermatology evaluation; however, most existing algorithms rely solely on images. Many diagnostic rules, including the 3-point checklist, are not considered by artificial intelligence algorithms, which comprise human knowledge and reflect the diagnosis process of human experts.

OBJECTIVE: In this paper, we aimed to develop a semisupervised model that can not only integrate the dermoscopic features and scoring rule from the 3-point checklist but also automate the feature-annotation process.

METHODS: We first trained the semisupervised model on a small, annotated data set with disease and dermoscopic …

The Spectral Sensitivity Of Human Circadian Phase Resetting And Melatonin Suppression To Light Changes Dynamically With Light Duration, Melissa A. St Hilaire, María L. Ámundadóttir, Shadab A. Rahman, Shantha M. W. Rajaratnam, Melanie Rüger, George C. Brainard, Charles A. Czeisler, Marilyne Andersen, Joshua J. Gooley, Steven W. Lockley

Department of Neurology Faculty Papers

Human circadian, neuroendocrine, and neurobehavioral responses to light are mediated primarily by melanopsin-containing intrinsically-photosensitive retinal ganglion cells (ipRGCs) but they also receive input from visual photoreceptors. Relative photoreceptor contributions are irradiance- and duration-dependent but results for long-duration light exposures are limited. We constructed irradiance-response curves and action spectra for melatonin suppression and circadian resetting responses in participants exposed to 6.5-h monochromatic 420, 460, 480, 507, 555, or 620 nm light exposures initiated near the onset of nocturnal melatonin secretion. Melatonin suppression and phase resetting action spectra were best fit by a single-opsin template with lambda_max at 481 and 483 …

Co-Management Strategies For Acute Myeloid Leukemia Patients In The Community Setting, Christopher Benton, Michael R Grunwald, Hana Safah, Margaret Kasner

Department of Medical Oncology Faculty Papers

The treatment landscape for acute myeloid leukemia (AML) has changed substantially in recent years. The introduction of newer therapies, including oral agents, less myelosuppressive agents, and parenteral regimens suitable for outpatient administration, has made it feasible for select patients to receive therapy in the outpatient setting and in community practices. Thorough patient evaluation (including molecular testing), planned supportive care (eg, transfusion support, antimicrobial prophylaxis), and vigilant patient monitoring (for tumor lysis syndrome and adverse events) by a multidisciplinary team are required for successful management of patients both in the community and at specialized leukemia centers. Some patients are unable or …

Gabapentin Disrupts Binding Of Perlecan To The Α 2Δ1 Voltage Sensitive Calcium Channel Subunit And Impairs Skeletal Mechanosensation, Perla C Reyes Fernandez, Christian S Wright, Adrianna N Masterson, Xin Yi, Tristen V Tellman, Andrei Bonteanu, Katie Rust, Megan L Noonan, Kenneth E White, Karl J Lewis, Uma Sankar, Julia M Hum, Gregory Bix, Danielle Wu, Alexander G Robling, Rajesh Sardar, Mary C Farach-Carson, William R Thompson

Faculty, Staff and Student Publications

Our understanding of how osteocytes, the principal mechanosensors within bone, sense and perceive force remains unclear. Previous work identified "tethering elements" (TEs) spanning the pericellular space of osteocytes and transmitting mechanical information into biochemical signals. While we identified the heparan sulfate proteoglycan perlecan (PLN) as a component of these TEs, PLN must attach to the cell surface to induce biochemical responses. As voltage-sensitive calcium channels (VSCCs) are critical for bone mechanotransduction, we hypothesized that PLN binds the extracellular α2δ1 subunit of VSCCs to couple the bone matrix to the osteocyte membrane. Here, we showed co-localization of PLN and α2δ1 along …

Mapping Single-Cell Transcriptomes In The Intra-Tumoral And Associated Territories Of Kidney Cancer, Ruoyan Li, John R Ferdinand, Kevin W Loudon, Georgina S Bowyer, Sean Laidlaw, Francesc Muyas, Lira Mamanova, Joana B Neves, Liam Bolt, Eirini S Fasouli, Andrew R J Lawson, Matthew D Young, Yvette Hooks, Thomas R W Oliver, Timothy M Butler, James N Armitage, Tev Aho, Antony C P Riddick, Vincent Gnanapragasam, Sarah J Welsh, Kerstin B Meyer, Anne Y Warren, Maxine G B Tran, Grant D Stewart, Isidro Cortés-Ciriano, Sam Behjati, Menna R Clatworthy, Peter J Campbell, Sarah A Teichmann, Thomas J Mitchell

Faculty, Staff and Student Publications

Tumor behavior is intricately dependent on the oncogenic properties of cancer cells and their multi-cellular interactions. To understand these dependencies within the wider microenvironment, we studied over 270,000 single-cell transcriptomes and 100 microdissected whole exomes from 12 patients with kidney tumors, prior to validation using spatial transcriptomics. Tissues were sampled from multiple regions of the tumor core, the tumor-normal interface, normal surrounding tissues, and peripheral blood. We find that the tissue-type location of CD8+ T cell clonotypes largely defines their exhaustion state with intra-tumoral spatial heterogeneity that is not well explained by somatic heterogeneity. De novo mutation calling from single-cell …

Gambaran Faktor Kegagalan Laten Dan Kegagalan Aktif Pada Kecelakaan Transportasi Darat Di Indonesia Tahun 2019 – 2021, Rahma Laili Khairina, Dadan Erwandi

National Journal of Occupational Health and Safety

Road transportation accidents are the eighth leading cause of death worldwide, reaching 1.35 million people annually (WHO, 2021). Data from the NTMC Korlantas Polri for 2019-2021 shows that the number of road transportation accidents in Indonesia is above 100 thousand every year. This study identifies latent and active failure factors contributing to Indonesia's land transportation accidents to determine the causes of accidents comprehensively. This study uses secondary data with 320,084 traffic accident case reports in 2019-2021 belonging to the NTMC Korlantas Polri. The method used is qualitative by analyzing based on the Swiss Cheese Model. The results of this study …

Analisis Faktor Yang Berhubungan Dengan Fatigue Pada Pegawai Dinas Kesehatan Provinsi Dki Jakarta Tahun 2022, Halimatuzzahra Halimatuzzahra, Dadan Erwandi

National Journal of Occupational Health and Safety

In 2020 cases of Covid-19 were found in various parts of the world, one of which was in Indonesia. Since it was first discovered, this case has continued to increase, with DKI Jakarta Province being the highest contributor to daily positive cases of Covid-19 in Indonesia. The Indonesian government continues to make efforts and cooperation between institutions. One of the institutions it has is the Health Agency. However, the arrangements and working conditions that have changed following the development of the Covid-19 case can cause fatigue for employees of the DKI Jakarta Health Agency.. This study aims to analyze the …

Place Cells Dynamically Refine Grid Cell Activities To Reduce Error Accumulation During Path Integration In A Continuous Attractor Model, Jose A Fernandez-Leon, Ahmet Kerim Uysal, Daoyun Ji

Faculty, Staff and Students Publications

Navigation is one of the most fundamental skills of animals. During spatial navigation, grid cells in the medial entorhinal cortex process speed and direction of the animal to map the environment. Hippocampal place cells, in turn, encode place using sensory signals and reduce the accumulated error of grid cells for path integration. Although both cell types are part of the path integration system, the dynamic relationship between place and grid cells and the error reduction mechanism is yet to be understood. We implemented a realistic model of grid cells based on a continuous attractor model. The grid cell model was …

Molecular Classification And Biomarkers Of Clinical Outcome In Breast Ductal Carcinoma In Situ: Analysis Of Tbcrc 038 And Rahbt Cohorts, Siri H Strand, Deborah J Veis, Katherine Deschryver, Jen Tappenden, Jingqin Luo, Shu Jiang, Graham A Colditz, Et Al.

2020-Current year OA Pubs

Ductal carcinoma in situ (DCIS) is the most common precursor of invasive breast cancer (IBC), with variable propensity for progression. We perform multiscale, integrated molecular profiling of DCIS with clinical outcomes by analyzing 774 DCIS samples from 542 patients with 7.3 years median follow-up from the Translational Breast Cancer Research Consortium 038 study and the Resource of Archival Breast Tissue cohorts. We identify 812 genes associated with ipsilateral recurrence within 5 years from treatment and develop a classifier that predicts DCIS or IBC recurrence in both cohorts. Pathways associated with recurrence include proliferation, immune response, and metabolism. Distinct stromal expression …

Tenotomy-Induced Muscle Atrophy Is Sex-Specific And Independent Of Nfκb, Gretchen A Meyer, Stavros Thomopoulos, Yousef Abu-Amer, Karen C Shen

2020-Current year OA Pubs

The nuclear factor-κB (NFκB) pathway is a major thoroughfare for skeletal muscle atrophy and is driven by diverse stimuli. Targeted inhibition of NFκB through its canonical mediator IKKβ effectively mitigates loss of muscle mass across many conditions, from denervation to unloading to cancer. In this study, we used gain- and loss-of-function mouse models to examine the role of NFκB in muscle atrophy following rotator cuff tenotomy - a model of chronic rotator cuff tear. IKKβ was knocked down or constitutively activated in muscle-specific inducible transgenic mice to elicit a twofold gain or loss of NFκB signaling. Surprisingly, neither knockdown of …