Medicine and Health Sciences Commons^™

Recommendations For Whole Genome Sequencing In Diagnostics For Rare Diseases, Erika Souche, Sergi Beltran, Erwin Brosens, John W Belmont, Magdalena Fossum, Olaf Riess, Christian Gilissen, Amin Ardeshirdavani, Gunnar Houge, Marielle Van Gijn, Jill Clayton-Smith, Matthis Synofzik, Nicole De Leeuw, Zandra C Deans, Yasemin Dincer, Sebastian H Eck, Saskia Van Der Crabben, Meena Balasubramanian, Holm Graessner, Marc Sturm, Helen Firth, Alessandra Ferlini, Rima Nabbout, Elfride De Baere, Thomas Liehr, Milan Macek, Gert Matthijs, Hans Scheffer, Peter Bauer, Helger G Yntema, Marjan M Weiss

Center for Medical Ethics and Health Policy Staff Publications

In 2016, guidelines for diagnostic Next Generation Sequencing (NGS) have been published by EuroGentest in order to assist laboratories in the implementation and accreditation of NGS in a diagnostic setting. These guidelines mainly focused on Whole Exome Sequencing (WES) and targeted (gene panels) sequencing detecting small germline variants (Single Nucleotide Variants (SNVs) and insertions/deletions (indels)). Since then, Whole Genome Sequencing (WGS) has been increasingly introduced in the diagnosis of rare diseases as WGS allows the simultaneous detection of SNVs, Structural Variants (SVs) and other types of variants such as repeat expansions. The use of WGS in diagnostics warrants the re-evaluation …

Will Anti-Vaccine Activism In The Usa Reverse Global Goals?, Peter J Hotez

Center for Medical Ethics and Health Policy Staff Publications

In the time of the COVID-19 pandemic, anti-vaccine activism in the USA accelerated, amplified and formed an alliance with political groups and even extremists. An organized, well-funded and empowered anti-science movement now threatens to spill over and threaten all childhood immunizations in the USA and globally.

An Ultra-Brief Screening Scale For Pediatric Obsessive-Compulsive Disorder: The Oci-Cv-5, Amitai Abramovitch, Jonathan S Abramowitz, Dean Mckay, Heining Cham, Kennedy S Anderson, Lara J Farrell, Daniel A Geller, Gregory L Hanna, Sharna Mathieu, Joseph F Mcguire, David R Rosenberg, S Evelyn Stewart, Eric A Storch, Sabine Wilhelm

Center for Medical Ethics and Health Policy Staff Publications

Background: Obsessive-compulsive disorder (OCD) is an often disabling and chronic condition that is normally assessed using diagnostic interviews or lengthy self-report questionnaires. This makes routine screening in general health settings impractical, and as a result OCD is often under-(or mis-)recognized. The present study reports on the development of an ultra-brief version of the Obsessive-Compulsive Inventory-Child Version (OCI-CV) which may be administered routinely as a screener for pediatric OCD.

Method: A total of 489 youth diagnosed with OCD, 259 non-clinical controls, and 299 youth with other disorders completed the OCI-CV and other indices of psychopathology. Using item analyses, we extracted five …

Mrnip Interacts With Sex Body Chromatin To Support Meiotic Progression, Spermatogenesis, And Male Fertility In Mice, Samina Kazi, Julio M Castañeda, Audrey Savolainen, Yiding Xu, Ning Liu, Huanyu Qiao, Ramiro Ramirez-Solis, Kaori Nozawa, Zhifeng Yu, Martin M Matzuk, Renata Prunskaite-Hyyryläinen

Faculty, Staff and Students Publications

Meiosis has a principal role in sexual reproduction to generate haploid gametes in both sexes. During meiosis, the cell nucleus hosts a dynamic environment where some genes are transcriptionally activated, and some are inactivated at the same time. This becomes possible through subnuclear compartmentalization. The sex body, sequestering X and Y chromosomes during male meiosis and creating an environment for the meiotic sex chromosome inactivation (MSCI) is one of the best known and studied subnuclear compartments. Herein, we show that MRNIP forms droplet‐like accumulations that fuse together to create a distinct subnuclear compartment that partially overlaps with the sex body …

Subclavian Steal Phenomenon Associated With Vascular Ring In An Infant Who Had A Prenatally Diagnosed Right Aortic Arch With An Atretic Aberrant Left Subclavian Artery, Daiji Takajo, Jennifer Blake, Sanjeev Aggarwal

The Texas Heart Institute Journal

Vascular ring is a rare congenital anomaly in which the abnormal origin of the aorta or its branches and pulmonary arteries leads to encircling and compression of the trachea and esophagus. A right aortic arch (RAA) with an aberrant left subclavian artery is one of the most common forms of vascular ring. Here, we report a case of a prenatally diagnosed vascular ring resulting from an RAA with an aberrant left subclavian artery. When the infant was 7 months of age, the development of noisy breathing prompted further evaluation with cardiac magnetic resonance imaging that showed an atretic left subclavian …

Hypertrophic Cardiomyopathy And Pregnancy: A Retrospective Analysis From A Tertiary Care Hospital, Pooja Sikka, Vanita Suri, Seema Chopra, Neelam Aggarwal, Subhas Chandra Saha, Ramandeep Bansal, Rajesh Vijayvergiya, Ajay Bahl

The Texas Heart Institute Journal

Pregnancy in women with hypertrophic cardiomyopathy is not well described. In this retrospective study, we analyzed data on pregnant women with hypertrophic cardiomyopathy who were under follow-up care in the cardiology department of a tertiary care hospital. We reviewed data on all women registered in the hypertrophic cardiomyopathy cohort and those who attended the cardio-obstetric clinic and delivered between January 2010 and June 2019. From these 2 groups, we identified 7 pregnant women with hypertrophic cardiomyopathy who delivered during this period. These 7 women (mean [SD] age, 25 [3.3] years) had a total of 15 pregnancies (range per woman,1–4). This …

Meta-Analysis: Outcomes Of Surgical And Medical Management Of Diabetic Foot Osteomyelitis, David H. Truong, Roger Bedimo, Matthew Malone, Dane K. Wukich, Orhan Oz, Amanda L. Killeen, Lawrence A. Lavery

School of Podiatric Medicine Publications

Background

The aim of this study was to evaluate clinical outcomes in the published literature on medical and surgical management of diabetic foot osteomyelitis (DFO).

Methods

A PubMed and Google Scholar search of articles relating to DFO was performed over the dates of January 1931 to January 2020. Articles that involved Charcot arthropathy, case reports, small case series, review articles, commentaries, nonhuman studies, and non-English articles were excluded. The Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) tool was used to rate the bias of each study. A meta-analysis was performed using random-effects and inverse variance methods. The search yielded 1192 …

B-Cell Lymphoblastic Lymphoma Of The Paranasal Sinus: A Rare Clinical Entity, Brian Anderson, Christopher M. Metz

Conference Presentation Abstracts

No abstract provided.

Perceptions Of The Virtual Interview Process: A National Survey Of Rhinology Fellowship Directors, Jared A. Johnson, Benjamin S. Johnson, Michael T. Chung, Adam Folbe

Conference Presentation Abstracts

No abstract provided.

Closing The Gap: Stapes Surgery Outcome And Operative Time Analysis By Body Mass Index, Jonathan S. Choi, Christian G Fritz, Dennis I. Bojrab Ii, Christopher P. Lenkeit

Conference Presentation Abstracts

No abstract provided.

Endolymphatic Sac Decompression Effect On Secondary Symptoms Of Ménière Diseas, Robert L. Conway, Seilesh C Babu, Patrick Mallany, Alexandria Weymon, Brent Wilkerson

Conference Presentation Abstracts

No abstract provided.

Utility Of Radiofrequency Treatment Of The Internal Nasal Valve Status Post Rhinoplasty: A Salvage Technique, Jake Sims, Andrew M. Compton

Conference Presentation Abstracts

No abstract provided.

Novel Mathematical Model For Diagnosis Of Superior Semicircular Canal Dehiscence, Garrett G. Casale, Christian G. Fritz, Lulia Kana, Robert S. Hong

Conference Presentation Abstracts

No abstract provided.

An Evaluation Of Patient-Reported Outcomes In Sickle Cell Disease Within A Conceptual Model., Marsha J Treadwell, Swapandeep Mushiana, Sherif M Badawy, Liliana Preiss, Allison A King, Barbara Kroner, Yumei Chen, Jeffrey Glassberg, Victor Gordeuk, Nirmish Shah, Angela Snyder, Theodore Wun, Sickle Cell Disease Implementation Consortium (Scdic)

2020-Current year OA Pubs

PURPOSE: To examine the relations between patient-reported outcomes (PROs) within a conceptual model for adults with sickle cell disease (SCD) ages 18 - 45 years enrolled in the multi-site Sickle Cell Disease Implementation Consortium (SCDIC) registry. We hypothesized that patient and SCD-related factors, particularly pain, and barriers to care would independently contribute to functioning as measured using PRO domains.

METHODS: Participants (N = 2054) completed a 48-item survey including socio-demographics and PRO measures, e.g., social functioning, pain impact, emotional distress, and cognitive functioning. Participants reported on lifetime SCD complications, pain episode frequency and severity, and barriers to healthcare.

RESULTS: Higher …

Efficacy And Safety Of Acupuncture And Or Moxibustion For Managing Primary Dysmenorrhea: A Systematic Review And Meta-Analysis, Weiting Liu, Carol Chunfeng Wang, Khui Hung Lee, Xiaopeng Ma, Timothy Leen Kang

Research outputs 2022 to 2026

Acupuncture and moxibustion have been accepted as add-on options for primary dysmenorrhea (PD); however, the clinical evidence is still inadequate. We searched AMED, CENTRAL, EMBASE, PubMed, Web of Science, CBM, CNKI, VIP, Wangfang database, ANZCTR, ClinicalTrials.gov, and the WHO ICTRP, from their inception to February 2021. The pooled analysis of 13 RCTs with 675 participants for VAS showed that acupuncture and moxibustion were more effective in managing PD than the control group with the MD of −1.93 (95% CI [−2.80, −1.06] and −2.67 (95% CI [−4.96, −0.38]). With the CMSS, seven studies with 487 participants showed that these modalities were …

Feasibility, Psychosocial Effects, Influence, And Perception Of Elastic Band Resistance Balance Training In Older Adults, Nichola M. Davis, Andy Pringle, Anthony D. Kay, Anthony J. Blazevich, Danielle Teskey, Mark A. Faghy, Minas A. Mina

Research outputs 2022 to 2026

This study utilised feedback from older adults during balance-challenging, elastic band resistance exercises to design a physical activity (PA) intervention. Methods: Twenty-three active participants, aged 51 – 81 years, volunteered to perform a mini balance evaluation test and falls efficacy scale, and completed a daily living questionnaire. Following a 10 min warm-up, participants performed eight pre-selected exercises (1 × set, 8 – 12 repetitions) using elastic bands placed over the hip or chest regions in a randomised, counterbalanced order with 15 min seated rests between interventions. Heart rate (HR) and rate of perceived exertion (RPE) were measured throughout. Participant interview …

Whole-Genome Sequencing Links Clostridium (Clostridioides) Difficile In A Single Hospital To Diverse Environmental Sources In The Community, Su-Chen Lim, Deirdre Collins, Korakrit Imwattana, Daniel R. Knight, Sicilia Perumalsamy, Natasza M.R. Hain-Saunders, Papanin Putsathit, David Speers, Thomas Riley

Research outputs 2022 to 2026

To investigate if Clostridium (Clostridioides) difficile infection (CDI), traditionally thought of as hospital-acquired, can be genomically linked to hospital or community environmental sources, and to define possible importation routes from the community to the hospital.

In 2019, C. difficile was isolated from 89/300 (29.7%) floor and 96/300 (32.0%) shoe sole samples at a tertiary hospital in Western Australia. Non-toxigenic C. difficile ribotype (RT) 010 predominated among floor (96.6%) and shoe sole (73.2%) isolates, while toxigenic RT 014/020 was most prevalent among contemporaneous clinical cases (33.0%) at the hospital. Whole-genome sequencing and high-resolution core genome single nucleotide polymorphism (cgSNP) …

Human Leucocyte Antigen Genotype Association With The Development Of Immune-Related Adverse Events In Patients With Non-Small Cell Lung Cancer Treated With Single Agent Immunotherapy, Afaf Abed, Ngie Law, Leslie Calapre, Johnny Lo, Vikas Bhat, Samantha Bowyer, Michael Millward, Elin S. Gray

Research outputs 2022 to 2026

Introduction: Biomarkers that predict the risk of immune-mediated adverse events (irAEs) among patients with non-small cell lung cancer (NSCLC) may reduce morbidity and mortality associated with these treatments. Methods: We carried out high resolution human leucocyte antigen (HLA)-I typing on 179 patients with NSCLC treated with anti-program death (PD)-1/program death ligand (PDL)-1. Toxicity data were collected and graded as per common terminology criteria for adverse event (CTCAE) v5.0. We used 14.8-week for landmark analysis to address lead-time bias to investigate the correlation between HLA-I/II zygosity, supertypes and alleles with irAE. Furthermore, we assessed the association for irAE with clinical benefit …

Application Of A Single-Tank Sequencing Batch Reactor For Long-Term Zebrafish Care, Aranya Ponpornpisit, Malinee Jongjaroenjai, Naowarat Suthamnatpong, Surachet Burut-Archanai

The Thai Journal of Veterinary Medicine

Sequencing batch reactors are efficient wastewater treatment systems, however, they are not adapted to treat aquaria. We aimed to compare the efficacies of a modified single-tank sequencing batch reactor (SSBR) and a regular overflow filtration system. Zebrafish were maintained in an acrylic aquarium connected to an SSBR or in a tank connected to a regular overflow filtration system for 27 weeks. Water change or aeration using air stone was not performed. The water quality in both groups was within the normal range until 26 weeks, after which the nitrite and nitrate levels increased. The average temperature was, 29.46 ± 0.71°C …

Microbial Diversity And Microbiological Quality Of Edible-Birdnest (Ebn) During Processing And Storage, Shazreena Zuber, Zunita Zakaria, Jalila Abu, Saleha Abdul Aziz

The Thai Journal of Veterinary Medicine

The microbial quality of 45 EBN consisting of raw unclean and raw clean Edible-birdnest (EBN) from two different premises were analyzed for 8 weeks. Using 3M™ Petrifilm, Total Aerobic Count (TAC) of raw clean EBN and Total Coliform Count (TCC) for raw unclean, 3 days, 2 weeks and 4 weeks EBN in both premises exceeded the limit stated in by the Malaysian Standard (MS 2334:2011; SIRIM/DVS 3:2015). A total of 264 bacteria and 208 fungi species were isolated. Bacteria isolated was identified using bioMérieux’s API® kit and a series of biochemical tests. Fungi were identified using techniques described by the …

Comparison Of Biomechanical Properties Associated With The Diameter And Insertion Depth Of Bone Anchors In The Femoral Condyle Of Toy Breed Cadaver Dogs, Yun-Hee An, Mu-Young Kim, Hun-Young Yoon

The Thai Journal of Veterinary Medicine

The objective of the present study was to compare the biomechanical properties of implanted bone anchors based on diameter and insertion depth to yield selection criteria for bone anchor size in toy breed dogs. Twenty toy breed dog cadavers weighing < 5 kg underwent placement of five types of veterinary bone anchors (short diameter, short length [SDSL]; short diameter, medium length [SDML]; medium diameter, medium length [MDML]; medium diameter, long length [MDLL]; and long diameter, medium length [LDML]) at a predetermined femoral attachment site. Anchor screw depth/femoral condyle width (FCW) and anchor screw diameter/femoral condyle length (FCL) were measured using radiography. The yield load, Young’s modulus and failure load were measured and the causes of failure for each construct were recorded. The anchor screw depth/FCW was < 50%, 50%–75%, ~50%, and 75%–100% in the SDSL, SDML, MDML, and MDLL groups, respectively. The yield load, Young’s modulus and failure load were higher in the SDML and MDLL groups than in the SDSL and MDML groups. The anchor screw diameter/FCL was 12%–15% and 24%–30% in the SDML and LDML groups, respectively. No differences in biomechanical parameters were found between the SDML and LDML groups. The cause of failure in all constructs was pull-out of the bone anchor, except for distal femur fracture in five LDML constructs. In conclusion, when implanting bone anchors in toy breed dogs, the insertion depth should be > 50% of the FCW, regardless of diameter. Moreover, distal femur fracture can occur if the bone anchor diameter/FCL ratio exceeds 24%.

Environmental Enrichment And The Behavioral Effects On Captive Beluga Whales (Delphinapterus Leucas), Tsung-Hsien Li, Evonne Lim, I-Chun Chen, Chuen-Fu Lin, Shih-Chu Chen, Ming-An Tsai

The Thai Journal of Veterinary Medicine

Environmental enrichment methods are meant to encourage animals to display their complete ethogram while under human care in zoos and aquariums. In this study, we sought to characterize the effectiveness of environmental enrichment (involving the inclusion of toys in the living environment) on captive beluga whales in the National Museum of Marine Biology and Aquarium. Our results indicate that belugas with toys spend less time floating and swimming repetitively than do belugas without toys. The presence of toys was also shown to enhance social interactions among captive belugas. Overall, our findings indicate that the provision of toys can enrich the …

Pueraria Mirifica Can Modulate The Ovarian Activity Of Crossbred-Thai Native Does, Phubet Satsook, Sukanya Rattanatabtimtong, Lak Piasai, Patcharapa Towiboon, Chalermchart Somgird, Anuchai Pinyopummin

The Thai Journal of Veterinary Medicine

To evaluate the effect of P. mirifica supplementation on ovarian activity in crossbred Thai native does, a study was carried out for three consecutive estrus cycle periods: 1) D0-D21(pre-treatment), 2) D21-D42 (treatment) and 3) D42-D63 (post-treatment); D0, D21 and D42 were the days of expected estrus. P. mirifica was orally fed at 1000 mg/kg BW/d for 21 days in supplemented groups. Twenty-one does were equally divided into three groups: 1) CON – control, no supplementation and 2) supplemented groups included 2.1) FEC – start feeding at early-cycle (D21-D42), and 2.2) FMC – start feeding at mid-cycle (D32-D53). Estrus behavior was …

Cloning, Expression And Identification Of Truncated Spike Gene Of Ibv (Sf200) And Chicken Granulocyte- Macrophage Colony Stimulating Factor (Gm-Csf), Tran Duc Hoan, Doan Thi Thao, Wang Bin

The Thai Journal of Veterinary Medicine

The aim of this study was to clone, express and identify the truncated S1 gene of nephrotropic infectious bronchitis virus (IBV) and granulocyte-monocyte colony stimulating factor (GM-CSF) of chicken. Firstly, two genes were amplified by polymerase chain reaction (PCR) and cloned into pMD18-T vector. The truncated S1 gene designated as Sf200 (containing five antigenic sites of S1 glycoprotein on amino acid residues (aa) 24–61, (aa) 291–398 and (aa) 497–543 and GM-CSF were then amplified from the respective recombinant pMD18-T plasmids and cloned into pET-32a (+) vector resulting pET-Sf200, pET-GM which were identified by restriction enzyme digestion and sequencing analysis. The …

Sex-Associated Differences In Patellotrochlear Morphology In Small-Breed Dogs, Radka S. Garnoeva

The Thai Journal of Veterinary Medicine

The purpose of this study was to make a between-sex comparison of trochlear groove and patellar metrics in healthy dogs on tangential radiographs. A total of 38 stifle joints from 19 healthy dogs (9 males; 10 females) from three small breeds (Pomeranian, Pinscher, Chihuahua) were evaluated. The following morphometric parameters of patella and trochlear groove were measured: trochlear sulcus angle (SA), lateral and medial trochlear inclination angles (LTI; MTI), trochlear groove depth (TD), retropatellar angle of Wiberg (WA), lateral and medial patellar facet angles (LFA, MFA), lateral and medial facet lengths (LF, MF), horizontal and vertical patellar diameters. In the …

Exposure To World Health Organization's Aware Antibiotics And Isolation Of Multidrug Resistant Bacteria: A Systematic Review And Meta-Analysis, Giorgia Sulis, Sena Sayood, Shashi Katukoori, Neha Bollam, Ige George, Lauren H. Yaeger, Miguel A. Chavez, Emmanuel Tetteh, Sindhu Yarrabelli, Celine Pulcini, Stephan Harbarth, Dominik Mertz, Mike Sharland, Lorenzo Moja, Benedikt Huttner, Sumanth Gandra

2020-Current year OA Pubs

BACKGROUND: Antibiotic use drives antibiotic resistance.

OBJECTIVES: To systematically review the literature and estimate associations between prior exposure to antibiotics across World Health Organization's (WHO) AWaRe categories (Access, Watch, Reserve) and isolation of critical and high-priority multidrug resistant organisms (MDROs) on the WHO priority pathogen list.

DATA SOURCES: Embase, Ovid Medline, Scopus, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov (from inception to 20/08/2020).

STUDY ELIGIBILITY CRITERIA: Case-control, cohort, or experimental studies that assessed the risk of infection/colonization with MDROs.

PARTICIPANTS: Inpatients or outpatients of any age and sex.

INTERVENTIONS: Prior exposure to antibiotics that …

Trends In Matriculation From Neurological Surgery Training Programs Into Academic Versus Private Practice, Neha Siddiqui, Vamsi P. Reddy, James L. Rogers, Donald K. E. Detchou, Imaima Casubhoy, Rhea Gopali, Subhang Bhalla, Mika Janbahan, Emily Morris, Meghna Priyanka Peesapati, Nitin Agarwal

2020-Current year OA Pubs

OBJECTIVE: A career in academic neurosurgery is an arduous endeavor. Specific factors influencing physician practice preferences remain unclear. This study analyzes data from the American Association of Neurological Surgeons membership identifying the impact of several demographic and educational characteristics influencing neurosurgical career choices centered on academia, private practice, or a combination in the United States.

METHODS: A list of all current neurosurgeons was obtained from the American Association of Neurological Surgeons membership, and information on physician characteristics was collected via internet searches and institutional databases. The practice type of all neurosurgeons considered in this study were categorized as follows: private …

Real-World Evidence Of Axicabtagene Ciloleucel For The Treatment Of Large B Cell Lymphoma In The United States, Caron A Jacobson, Armin Ghobadi, Et Al.

2020-Current year OA Pubs

Axicabtagene ciloleucel (axi-cel) is a standard-of-care for patients with relapsed or refractory (r/r) large B cell lymphoma who have received 2 or more lines of prior therapy. Patients receiving axi-cel in the real world could have broader a demographic, disease, and treatment profile compared with that of the cohort in the pivotal ZUMA-1 trial. The present study was conducted to evaluate the outcomes of axi-cel therapy in the real-world setting. A total of 1297 patients receiving commercial axi-cel between 2017 and 2020 were selected from the Center for International Blood and Marrow Transplant Research's data registry, of whom 739 (57%) …

Substance Use And Common Contributors To Morbidity: A Genetics Perspective, Sandra Sanchez-Roige, Rachel L Kember, Arpana Agrawal

2020-Current year OA Pubs

Excessive substance use and substance use disorders (SUDs) are common, serious and relapsing medical conditions. They frequently co-occur with other diseases that are leading contributors to disability worldwide. While heavy substance use may potentiate the course of some of these illnesses, there is accumulating evidence suggesting common genetic architectures. In this narrative review, we focus on four heritable medical conditions - cardiometabolic disease, chronic pain, depression and COVID-19, which are commonly overlapping with, but not necessarily a direct consequence of, SUDs. We find persuasive evidence of underlying genetic liability that predisposes to both SUDs and chronic pain, depression, and COVID-19. …

Methylation-Mediated Silencing Of Ptprd Induces Pulmonary Hypertension By Promoting Pulmonary Arterial Smooth Muscle Cell Migration Via The Pdgfrb/Plcγ1 Axis, Junhua Xu, Yanfeng Zhong, Haoyang Yin, John Linneman, Yixuan Luo, Sijian Xia, Qinyi Xia, Lei Yang, Xingtao Huang, Kang Kang, Jun Wang, Yanqin Niu, Li Li, Deming Gou

2020-Current year OA Pubs

OBJECTIVE: Pulmonary hypertension is a lethal disease characterized by pulmonary vascular remodeling and is mediated by abnormal proliferation and migration of pulmonary arterial smooth muscle cells (PASMCs). Platelet-derived growth factor BB (PDGF-BB) is the most potent mitogen for PASMCs and is involved in vascular remodeling in pulmonary hypertension development. Therefore, the objective of our study is to identify novel mechanisms underlying vascular remodeling in pulmonary hypertension.

METHODS: We explored the effects and mechanisms of PTPRD downregulation in PASMCs and PTPRD knockdown rats in pulmonary hypertension induced by hypoxia.

RESULTS: We demonstrated that PTPRD is dramatically downregulated in PDGF-BB-treated PASMCs, pulmonary …