Medicine and Health Sciences Commons^™

Retinoic Acid Receptor Activation Reduces Metastatic Prostate Cancer Bone Lesions By Blocking The Endothelial-To-Osteoblast Transition, Guoyu Yu, Paul G Corn, Pengfei Shen, Jian H Song, Yu-Chen Lee, Song-Chang Lin, Jing Pan, Sandeep K Agarwal, Theocharis Panaretakis, Maurizio Pacifici, Christopher J Logothetis, Li-Yuan Yu-Lee, Sue-Hwa Lin

Faculty, Staff and Students Publications

Metastatic prostate cancer (PCa) in the bone induces bone-forming lesions that contribute to progression and therapy resistance. PCa-induced bone originates from endothelial cells (EC) that have undergone endothelial-to-osteoblast (EC-to-OSB) transition in response to tumor-secreted BMP4. Current strategies targeting PCa-induced bone formation are lacking. Here, we show that activation of retinoic acid receptor (RAR) inhibits EC-to-OSB transition and reduces PCa-induced bone formation. Treatment with palovarotene, an RARγ agonist being tested for heterotopic ossification in fibrodysplasia ossificans progressiva, inhibited EC-to-OSB transition and osteoblast mineralization in vitro and decreased tumor-induced bone formation and tumor growth in several osteogenic PCa models, and similar effects …

Dependence On A Variable Residue Limits The Breadth Of An Hiv Mper Neutralizing Antibody, Despite Convergent Evolution With Broadly Neutralizing Antibodies, Cathrine Scheepers, Prudence Kgagudi, Nonkululeko Mzindle, Elin S. Gray, Thandeka Moyo-Gwete, Bronwen E. Lambson, Brent Oosthuysen, Batsirai Mabvakure, Nigel J. Garrett, Salim S.Abdool Karim, Lynn Morris, Penny L. Moore

Research outputs 2022 to 2026

Broadly neutralizing antibodies (bNAbs) that target the membrane-proximal external region (MPER) of HIV gp41 envelope, such as 4E10, VRC42.01 and PGZL1, can neutralize > 80 % of viruses. These three MPER-directed monoclonal antibodies share germline antibody genes (IGHV1 - 69 and IGKV3 - 20) and form a bNAb epitope class. Furthermore, convergent evolution within these two lineages towards a ^111.2GW^111.3 motif in the CDRH3 is known to enhance neutralization potency. We have previously isolated an MPER neutralizing antibody, CAP206 - CH12, that uses these same germline heavy and light chain genes but lacks breadth (neutralizing only 6 % of …

Pediatric Supracondylar Humeral Fractures: Epidemiology And Mechanisms Of Injury During The Covid-19 Pandemic, Dan Cohen, Jeffrey Kay, Mohammed Shehab, Darren De Sa, Devin C. Peterson, Waleed Kishta

Western Journal of Orthopaedics

Background: The purpose of this study was to evaluate the impact of the COVID-19 pandemic activity restrictions on pediatric supracondylar humerus fracture epidemiology in terms of both mechanism of injury and fracture patterns.

Methods: This was a retrospective chart review of all patients presenting with types II-IV supracondylar humerus fractures between March 15^th and June 30^th 2020 at the McMaster University Medical Centre. Data were collected from our secure electronic medical records for information on patient demographic data, mechanism of injury, operative reports and imaging. 5 treating surgeons independently analyzed each patient’s radiographs and classified them according …

Medical Autopsy For Sudden Unexplained Death In Saudi Arabia: A Call To Action, Wael Alqarawi, Abdulelah Alsaeed, Malak Alghamdi, Ahmed Hersi, Tarek Kashour, Khaldoon Aljerian

Journal of the Saudi Heart Association

Sudden unexplained death (SUD) is a sudden, unexpected, and unexplained death in an individual older than 1 year. It is one of the most devastating and tragic events to families and the community at large, particularly when it happens at a young age. Finding the cause of SUD is extremely important in order to prevent its recurrence in the family, and to help understand the epidemiology of SUD in the community. It has been well-established that the most effective way of finding the cause of SUD is by performing a medical autopsy. In many countries, medical autopsy is mandated in …

Impact Of Resin Composite Restorative Material Pre-Heating On Dental Pulp Temperature: A Laboratory Study, Asmaa S. El-Saeed, Fatma A. Elerian, Hamdi H. Hamama, Salah H. Mahmoud

Mansoura Journal of Dentistry

Objective: To investigate and compare the impact of pre-heating of an ormocer-based and a methacrylate-based restorative materials at different temperature on intra-pulpal temperature with that at room temperature. Materials and Methods: In the current study, two bulk-fill composite systems; one ormocer-based, and one methacrylate-based were used according to their manufacturer instructions. A total of 30 sound maxillary human molars was selected, and prepared by removal of occlusal enamel and part of dentin till remaining dentin thickness becomes 2 mm above highest pulp horn. The specimens were assigned equally into two halves, according to type restorative material used (n=15 for each). …

Transformative, Noetic, And Transpersonal Experiences During Personal Development Workshops, Helané Wahbeh, Cassandra Vieten, Garret Young, Agnes Cartry-Jacobsen, Dean Radin, Arnaud Delorme

International Journal of Transpersonal Studies Advance Publication Archive

The global personal development market was valued at $38.28 billion in 2019 and is expected to grow an additional 5% from 2020 to 2027. Many of these workshops promise to be transformational. This secondary analysis study examined transformative, transpersonal, and noetic aspects of personal development workshops. We found that 74% of post-survey records endorsed that participants experienced a moment of clarity or profound insight during their workshop. In addition, 66% endorsed that participants had experienced at least one noetic experience, and 84% endorsed at least one transpersonal experience. These analyses provide preliminary evidence for the transformational potential of personal development …

Assessing Ground Reaction Forces And Degenerative Changes Of Sound Limb In Unilateral Lower Extremity Amputees: A Systematic Review, Kira Donnelly, Colin Davis, Nicole Liotta, Angela Perkins, Vibhor Agrawal, Michael Jason Highsmith, Scott Michael Love

Physical Therapy Collection

Abstract Background: There is a rising number of individuals undergoing lower extremity amputation (LEA) and is associated with increased risk of comorbidities. Osteoarthritis (OA) and Degenerative Joint Disease (DJD) are conditions that cause reduction in an individual’s function, independence, and quality of life.

Research Design: A search of multiple databases using terms associated with possible functional declines as evidenced by the International Classification of Functioning, Disability and Health (ICF), followed by assessment of evidence using the PEDro scoring method will be conducted. Multiple reviewers will screen, sort, rate and extract data from articles.

Methods: A computer-aided literature search of PubMed, …

Comparison Between The Effect Of Bisphosphonates And Concentrated Growth Factors On Bone Healing Experimental Study, Mohammed A. Naji, Rana M. Nagah, Fakhreldin H. Abdel-Rahman, Hamdy A. Marzook

Mansoura Journal of Dentistry

Objective: Objectives: The aim of study was to compare the histological effect of Bisphosphonates (BPH) and Concentrated growth factors (CGFs) in bone defect healing. Materials and Methods: This experimental trial was conducted on 8 adults healthy New Zealand male rabbits weighing (2–3kgs). The rabbits are grouped as following: 4 rabbits in the CGF group and 4 rabbits in the BPH group and then sub-grouped according to sacrification time into 2 and 4 weeks in each rabbit. Two circular bone defects were created in the tibia (so every group have 8 defect). After that, each rabbit was treated by either BPH …

Evaluation Of The Effects Of The Incisal Capping Twin Block On The Flaring Of The Lower Incisors In The Treatment Of Skeletal Class Ii Malocclusion, Asmaa A. Elabd, Marwa A. Tawfik, Ahmed M. Hafez

Mansoura Journal of Dentistry

Objective: The purpose of this research was to evaluate the effect of the incisal capped Twin Block on the proclination of the lower incisors in the treatment of skeletal class II malocclusion. Materials and Methods: Ten patients (age ranged from 9 to 14 y) with skeletal class II due to mandibular retrusion were selected and treated with the incisal capped Twin Block appliance. Overjet was more than 4 mm. Lateral cephalometric radiographs, photographs, and study casts were obtained before and after treatment. The collected data were analyzed using (SPSS) program for Windows (Standard version 26). The treatment duration was about …

Comparative Evaluation Of Shaping Ability And Cleaning Efficiency Of Three Different Nickel-Titanium Rotary Systems, Reham I. Zehairy, Manal F. Osman, Amro A. Abd El-Razik

Mansoura Journal of Dentistry

Objective: This study was conducted to compare the shaping ability and cleaning efficiency of Mtwo, ProTaper Next and HyFlex CM rotary systems. Materials and Methods: A total of 45 root canals with curvatures ranging between 20o and 40o were divided into three groups of 15 canals: Mtwo, ProTaper Next and HyFlex CM based on pre-instrumentation radiographs. Canals were prepared to an apical size of 30. Using pre- and post-instrumentation radiographs, canal straightening was determined with a computer image analysis program. Preparation time was also recorded. These data were analysed using one-way analysis of variance (ANOVA) and post hoc Tukey’s test, …

Accuracy Of Digital Models In Bolton Analysis For Angle Class I Malocclusion Group, Ibrahim M. Abd-Elgawad, Marwa S. Shamaa, Ahmed M. Fouda

Mansoura Journal of Dentistry

Objective: This study aimed to test the accuracy and reliability of measurements using digital models versus plaster models. Materials and Methods: Thirty patients were recruited in the study. Impressions were taken for all patients by alginate impression material and poured immediately using certain dental plaster with good dimensional accuracy and surface details reproduction. All casts were trimmed and polished for obtaining high quality study models. Bolton analysis was done by manual and digital techniques for all casts. Intra-operator reliability testing and Paired-samples t-tests was used to compare the measurements within groups. Results: There was an excellent intra-operator reliability for both …

Comparison Of Cyclic Fatigue Resistance Of Three Ni-Ti Rotary Files, Mohamed A. El-Dreny, Mohamed M. Ibrahim, Amany E. Badr

Mansoura Journal of Dentistry

Objective: To compare the cyclic fatigue resistance of three Ni-Ti rotary files. Materials and Methods: A number of forty-five different nickel titanium rotary instruments (n = 15) were used in this study. All files were used according to their manufacturers' instructions. A specially designed, custom-made cyclic fatigue testing device was used in this study. The device had a simulated curved root canal within a stainless-steel block with a 45° angle of curvature and 5 mm radius of curvature. The time to fracture (TtF) in seconds was recorded visually using stopwatch. To characterize fracture mode, fractured fragments from each group were …

Effect Of Over-The-Counter Whitening Products On Enamel Color Change And Surface Roughness - A Laboratory Study, Estbrq A. Mousa, Radwa I. El-Toukhy, Ashraf I. Ali

Mansoura Journal of Dentistry

Objective: To evaluate the effect of various over-the-counter whitening products on enamel color change and surface roughness. Materials and Methods: Ninety bovine teeth were collected and sectioned at the cementoenamel junction. Fifty teeth were selected and stained for color change test. They were randomly divided into five groups according to the whitening product applied (n= 10). Color measurements were carried out with a spectrophotometer. The remaining Forty teeth were used for surface roughness test, where they were randomly divided into four groups n=10. Surface roughness was evaluated with optical profilometer. Results: The color change (Δ��) was significantly greater in the …

Antimicrobial Efficacy Of Different Root Canal Irrigants In Primary Teeth: Clinical Study, Nada H. Elmenbawy, Ahmed H. Wahba, Doaa Masallat, Salwa Awad

Mansoura Journal of Dentistry

Objective: Evaluation of antibacterial efficacy of 2.5% Sodium Hypochlorite (NaOCl), 3.8% Silver Diamine Fluoride (SDF), and 25% water-soluble extract of Propolis as root canal irrigants in primary molars. Materials and Methods: Thirty primary molars with a necrotic pulp of children in the age group 4-7 years were selected and divided into 3 groups randomly based on the irrigating solution used. In group A, 2.5% NaOCl was used as a positive control group. In groups B and C, 3.8% SDF and 25% water-soluble extract of Propolis were used respectively. The bacterial samples were collected pre-and post-irrigation using paper points and transferred …

The Expression Of Bmi-1 In Ameloblastoma And Dentigerous Cyst, Omnia S. Mohamed, Azza A. Elsissi, Osama A. Elkashty

Mansoura Journal of Dentistry

Objective: To check for a possible relation between the expression of BMI-1 among two different odontogenic lesions; ameloblastoma and dentigerous cyst known for different biological behavior. Materials and Methods: The study was conducted on 14 formalin-fixed paraffin-embedded blocks (ameloblastoma (Am) group: seven blocks and dentigerous cyst (DC) group: seven blocks). These blocks were collected from archived files of the Department of Oral Pathology, Faculty of Dentistry, Mansoura University. Immunohistochemically (IHC), the BMI-1 polyclonal antibody expression in the retrieved sections was investigated. A computerized method was used to compare the IHC staining intensity between both groups. Results: The difference in the …

Awareness Of Evidence Based Recommendations On Toothbrush Bristles Design And Texture Among Dentists, Nasr M. Attia, Ahmed Mahmoud Etman

Mansoura Journal of Dentistry

Objective: Dental plaque is a necessary etiologic factor in the onset and progression of dental caries and periodontal disorders. Numerous individual and material-based factors have an impact on dental plaque control. In light of the most recent evidence-based guidelines, this study's purpose is to determine the best toothbrush bristles surface plane design (flat; multilevel; angled), texture (soft; medium; hard) and to estimate how many dentists are aware of that too. Materials and Methods: This is a one-question survey directed on social media platforms of dentists' groups: - “Is it preferable to use a toothbrush with soft or medium bristles, and …

2022-09-01_Michiganoverview_Misc, Michigan Department Of Health & Human Services

Michigan COVID-19 MIS-C Data

The MIS-C Data page was obtained from Michigan's COVID-19 data page: https://www.michigan.gov/coronavirus/stats/mis-c-reporting.

This report is created by the Michigan Department of Health & Human Services from data self-reported by health care providers and local health departments. Data is updated on the first and third Thursdays of the month.

Multisystem Inflammatory Syndrome in Children (MIS-C) is a condition in children and adolescents under 21 years of age where multiple organ systems become inflamed or dysfunctional which occurs in association with illness. Children with MIS-C may have a fever and various symptoms, including abdominal (gut) pain, vomiting, diarrhea, neck pain, rash, …

Screening And Assessment Of Cancer-Related Fatigue: An Executive Summary And Road Map For Clinical Implementation, Joy C. Cohn, Shana Harrington, Jeannette Lee, Daniel Malone, Mary I. Fisher

Physical Therapy Faculty Publications

Background: Cancer-related fatigue (CRF) prevalence is reported as high as 90%. Cancer-related fatigue is multidimensional and associated with lower health-related quality of life. Effective screening and assessment are dependent upon use of valid, reliable, and clinically feasible measures. This Executive Summary of the Screening and Assessment of Cancer-related Fatigue Clinical Practice Guideline provides recommendations for best measures to screen and assess for CRF based on the quality and level of evidence, psychometric strength of the tools, and clinical utility.

Methods: After a systematic review of the literature, studies evaluating CRF measurement tools were assessed for quality; data extraction included psychometrics …

Preparation, Characterization And Pharmacokinetics Of Tolfenamic Acid-Loaded Solid Lipid Nanoparticles, Wei Xu, Zhaoyou Deng, Yifei Xiang, Dujuan Zhu

Faculty and Student Publications

The clinical use of nonsteroidal anti-inflammatory drugs is limited by their poor water solubility, unstable absorption, and low bioavailability. Solid lipid nanoparticles (SLNs) exhibit high biocompatibility and the ability to improve the bioavailability of drugs with low water solubility. Therefore, in this study, a tolfenamic acid solid lipid nanoparticle (TA-SLN) suspension was prepared by a hot melt–emulsification ultrasonication method to improve the sustained release and bioavailability of TA. The encapsulation efficiency (EE), loading capacity (LC), particle size, polydispersity index (PDI), and zeta potential of the TA-SLN suspension were 82.50 ± 0.63%, 25.13 ± 0.28%, 492 ± 6.51 nm, 0.309 ± …

A Proposed Value Metric To Quantify Value In Outpatient Therapy, Bryan Bourcier Dpt, Scs, Thomas Ruediger Dpt, Ocs, Scs, Alexandra Bond Dpt

Other Specialties

ABSTRACT

Study Design: Case report

Objectives: The purpose of this study is to report the steps towards developing a single number Value Metric that represents both the quality and cost of clinical care for outpatient therapy that can be used in real time.

Background: As healthcare continues to move towards value-based and risk-based reimbursement, it is imperative that leaders in outpatient therapy settings understand and can quantify the value of the services that therapists provide.

Methods and Measures: This study proposes a Value Metric to quantify value in outpatient therapy using existing quality and cost data. The Value Metric was …

Himmelfarb Headlines - September / October 2022, The George Washington University, Himmelfarb Health Sciences Library

Himmelfarb Headlines (2009 - present)

News, information, and resources relating to Himmelfarb Library that is of interest to patrons.

Gunshot Wound To The Chest With Retained Epicardial Bullet., Toba Bolaji, Abuoma C Ekpendu, Frederick Giberson

Transitional Year Resident Research

Gunshot wounds remain the most common cause of penetrating injuries in children and adolescents and the second leading cause of death among youth in the United States. Penetrating cardiac injuries carry a significantly increased mortality rate. The extent of damage caused depends on the type of firearm, the bullet used, the velocityand the trajectory. Therefore, rapid diagnosis and treatment is of the utmost importance. We report a case of a 19-year-old boy who presented to ouremergency department (ED) after sustaining a gunshot wound (GSW) to the right chest. In the ED, the patient was stabilized and a large hematoma was …

Effect Of Different Surface Treatments And Repair Materials On Shear Bond Strength Of Bulk-Fill Resin Composite, Alyaa A. Soliman, Rabab Mehesen, Ashraf I. Ali

Mansoura Journal of Dentistry

Objective: To evaluate the effect of different surface treatments on shear bond strength (SBS) between bulk-fill resin composite (BFRC) and bulk-fill flowable resin composite (BFFRC) or conventional flowable resin composite (CFRC). Materials and Methods: Sixteen blocks were prepared from Tetric N-Ceram BFRC, aged by thermo-cycling, and then stored in artificial saliva for 6 months. The blocks were divided into 4 groups (n=4) according to the surface treatment; Group1: roughened by coarse discs, Group 2: roughened by coarse discs and silanization, Group 3: roughened by air abrasion, and Group 4: roughened by air abrasion and silanization. Each group was subdivided into …

2022-09-01_Michiganoverview_Covidoutbreak, Michigan Department Of Health & Human Services

Michigan COVID-19 Outbreak Reports

The Outbreak Data page was obtained from Michigan's COVID-19 data page: https://www.michigan.gov/coronavirus/stats/outbreak-reporting.

This report is created by the Michigan Department of Health & Human Services from data self-reported by local health departments. Data is updated every week.

COVID-19 outbreaks are generally defined as two or more cases with a link by place and time indicating a shared exposure outside of a household. Local health departments report the number of new and ongoing outbreaks they are investigating by the setting of the outbreak. New outbreaks are those outbreaks that were first identified during the current reporting week. Ongoing outbreaks are …

Testing The Pragmatic Effectiveness Of A Consumer-Based Mindfulness Mobile App In The Workplace: Randomized Controlled Trial, Jennifer L. Huberty, Hallie M. Espel-Huynh, Taylor L. Neher, Megan E. Puzia

Public and Population Health Faculty Publications and Presentations

Background: Mental health and sleep problems are prevalent in the workforce, corresponding to costly impairment in productivity and increased health care use. Digital mindfulness interventions are efficacious in improving sleep and mental health in the workplace; however, evidence supporting their pragmatic utility, potential for improving productivity, and ability to reduce employer costs is limited.

Objective: This pragmatic, cluster randomized controlled trial aimed to evaluate the experimental effects of implementing a commercially available mindfulness app—Calm—in employees of a large, multisite employer in the United States. Outcomes included mental health (depression, anxiety, and stress), sleep (insomnia and daytime sleepiness), resilience, productivity impairment …

Therapeutic Jurisprudence In Practice: Applying Goffman’S Dramaturgical Approach To Mental Health Courts, Karen A. Snedker

Sociology Faculty Books and Book Chapters

"This chapter draws on qualitative data from two MHCs [mental health courts] to show how team members translate the tenets of therapeutic jurisprudence into the performance of their social roles in both formal and informal court settings. I argue that the successful operation of teamwork lies at the heart of MHC effectiveness. Judges, acting as both audience and team member, can undermine the work of the team. MHCs clearly rely upon a well-functioning collaborative team, working partially in backstage settings, with a judge willing to alter frontstage performances for the sake of collaboration and therapeutic effects for clients."

Tetrahydrocurcumin Improves Lipopolysaccharide-Induced Myocardial Dysfunction By Inhibiting Oxidative Stress And Inflammation Via Jnk/Erk Signaling Pathway Regulation, Hanzhao Zhu, Liyun Zhang, Hao Jia, Lu Xu, Yu Cao, Mengen Zhai, Kaifeng Li, Lin Xia, Liqing Jiang, Xiang Li, Yenong Zhou, Jincheng Liu, Shiqiang Yu, Weixun Duan

Chemistry Undergraduate Publications

Background

Acute myocardial dysfunction in patients with sepsis is attributed to oxidative stress, inflammation, and cardiomyocyte loss; however, specific drugs for its prevention are still lacking. Tetrahydrocurcumin (THC) has been proven to contribute to the prevention of various cardiovascular diseases by decreasing oxidative stress and inflammation. This study was performed to investigate the functions and mechanism of action of THC in septic cardiomyopathy.

Methods

After the oral administration of THC (120 mg/kg) for 5 consecutive days, a mouse model of sepsis was established via intraperitoneal lipopolysaccharide (LPS, 10 mg/kg) injection. Following this, cardiac function was assessed, pathological section staining was …

Prescribing Controlled Substances Goes Electronic, Alberto Coustasse, Craig Kimble, Ken Maxik

Management Faculty Research

With the Affordable Care Act in 2010 came interoperability and meaningful use requirements. Part of these requirements included the implementation of electronic medical records (EMRs), which was a crucial part of achieving these standards. With EMRs, prescribers began sending electronic prescriptions. EMRs can provide advanced decision support when writing prescriptions, and they include features such as auto populating the quantity prescribed, formulary information, therapeutic duplications, warnings about interactions, or other potential clinical or regulatory issues. This system results in enhanced patient care and a more streamlined dispensing process. In addition, electronic prescriptions for controlled substances (EPCS) has become more widely …

Osteoporosis Knowledge And Health Beliefs Among Middle-Aged Men And Women In The Southern United States, Stacy Chelf, Robert E. Davis, Martha A. Bass, M. Allison Ford, Ali D. Firouzabadi, Jonathan T. Leo, Vinayak K. Nahar

Faculty and Student Publications

Context: The most common skeletal disease, osteoporosis, causes bone fragility due to decreased bone mass and bone microarchitecture destruction. The health belief model is often applied to asymptomatic, prevention-related diseases such as osteoporosis. Steps to mitigate the insidious nature of osteoporosis, including education, motivation, and monitoring of bone mineral density, must begin at an earlier age. Objectives: This study evaluates the knowledge and health beliefs surrounding osteoporosis in a population of males and females 35–50 years old to determine sex-based differences in osteoporosis knowledge and beliefs and to assess the correlation between perceptions and health motivation. Methods: Participants (81 males, …

Screening Considerations For Patients With Sexually Transmitted Infections, Children's Mercy Kansas City

Clinical Critically Appraised Topics

No abstract provided.