Medicine and Health Sciences Commons^™

Discovery And Characterization Of Potent, Efficacious, Orally Available Antimalarial Plasmepsin X Inhibitors And Preclinical Safety Assessment Of Ucb7362, Martin A Lowe, Daniel E Goldberg, Et Al.

2020-Current year OA Pubs

Plasmepsin X (PMX) is an essential aspartyl protease controlling malaria parasite egress and invasion of erythrocytes, development of functional liver merozoites (prophylactic activity), and blocking transmission to mosquitoes, making it a potential multistage drug target. We report the optimization of an aspartyl protease binding scaffold and the discovery of potent, orally active PMX inhibitors with in vivo antimalarial efficacy. Incorporation of safety evaluation early in the characterization of PMX inhibitors precluded compounds with a long human half-life (

A Framework For Detecting Noncoding Rare-Variant Associations Of Large-Scale Whole-Genome Sequencing Studies, Zilin Li, Xihao Li, Hufeng Zhou, Sheila M. Gaynor, Margaret Sunitha Selvaraj, Theodore Arapoglou, Corbin Quick, John Blangero, Joanne E. Curran, Ravindranath Duggirala, Harald H. H. Goring

School of Medicine Publications

Large-scale whole-genome sequencing studies have enabled analysis of noncoding rare-variant (RV) associations with complex human diseases and traits. Variant-set analysis is a powerful approach to study RV association. However, existing methods have limited ability in analyzing the noncoding genome. We propose a computationally efficient and robust noncoding RV association detection framework, STAARpipeline, to automatically annotate a whole-genome sequencing study and perform flexible noncoding RV association analysis, including gene-centric analysis and fixed window-based and dynamic window-based non-gene-centric analysis by incorporating variant functional annotations. In gene-centric analysis, STAARpipeline uses STAAR to group noncoding variants based on functional categories of genes and incorporate …

Genetic Addiction Risk And Psychological Profiling Analyses For "Preaddiction" Severity Index, Kenneth Blum, Mark S Gold, Et Al.

2020-Current year OA Pubs

Since 1990, when our laboratory published the association of the

Strategies For De-Implementation Of Low-Value Care-A Scoping Review, Sara Ingvarsson, Henna Hasson, Ulrica Von Thiele Schwarz, Per Nilsen, Byron J Powell, Clara Lindberg, Hanna Augustsson

2020-Current year OA Pubs

BACKGROUND: The use of low-value care (LVC) is a persistent problem that calls for knowledge about strategies for de-implementation. However, studies are dispersed across many clinical fields, and there is no overview of strategies that can be used to support the de-implementation of LVC. The extent to which strategies used for implementation are also used in de-implementing LVC is unknown. The aim of this scoping review is to (1) identify strategies for the de-implementation of LVC described in the scientific literature and (2) compare de-implementation strategies to implementation strategies as specified in the Expert Recommendation for Implementing Change (ERIC) and …

Mindfulness Training For Depressed Older Adults Using Smartphone Technology: Protocol For A Fully Remote Precision Clinical Trial, Abigail Schweiger, Thomas L Rodebaugh, Eric J Lenze, Katie Keenoy, Jason Hassenstab, Jeanne Kloeckner, Torie R Gettinger, Ginger E Nicol

2020-Current year OA Pubs

BACKGROUND: Precision medicine, optimized interventions, and access to care are catchphrases for the future of behavioral treatments. Progress has been slow due to the dearth of clinical trials that optimize interventions' benefits, individually tailor interventions to meet individual needs and preferences, and lead to rapid implementation after effectiveness is demonstrated. Two innovations have emerged to meet these challenges: fully remote trials and precision clinical trials.

OBJECTIVE: This paper provides a detailed description of Mindful MyWay, a study designed to test online mindfulness training in older adults with depression. Consistent with the concept of fully remote trials using a smartphone app, …

Feasibility Of Cell Phone Surveys In People With Mental Illness Experiencing Homelessness During Covid-19, Tina Thomas, Namrata Walia, Landon Presnall, Jasper Shei, Jane Elizabeth Hamilton

Journal of Digital Psychiatry

People experiencing homelessness (PEH) may be at increased risk for negative physical and mental health outcomes in the context of community spread of COVID-19. Research into the impacts of COVID-19 on this vulnerable population can be affected by inaccessibility and poor engagement resulting in minimal representation in population-based survey data. The increased use of mobile phone technology (mHealth) to provide medical and psychiatric care during the COVID-19 pandemic could provide an effective platform for gathering data from this hard-to-reach group. This paper examines feasibility, via review of the barriers and facilitators, of using a mobile phone intervention to administer a …

Journal Of Digital Psychiatry: A New Journal, Salih Selek

Journal of Digital Psychiatry

no abstract

Uthealth Quality Symposium 2022 Abstracts

Teaching in Clinics

No abstract

Characteristics Of Academic Anesthesiologist’S Elected To An Institutional Academy Of Master Educators, Evan G. Pivalizza, Sara Guzman-Reyes, Christopher Stephens, Rhashedah A. Ekeoduru, Omonele O. Nwokolo, Katherine C. Normand, Srikanth Sridhar, Travis H. Markham, Johanna B. Dehaan, George Williams, Gary C. Rosenfeld

Teaching in Clinics

Background. The educational experience and success of academic anesthesiologists may be elusive to quantify. We wished to examine the characteristics of a cohort of anesthesiology faculty who were inducted into a medical school master educator academy over the last decade.

Methods. After IRB approval with waiver of consent, all 10 anesthesiology faculty inductees into the academy supplied relevant data for their accomplishments at the time of induction in multiple educational domains, including teaching and assessment, mentoring and advising, evidence of scholarship and production of enduring materials, and educational leadership. These were deidentified and analyzed.

Results. The cohort had evidence of …

Teaching In Clinics: A New Perspective To Healthcare Education

Teaching in Clinics

No abstract

Covid-19-Impacted Research And Education In Global Healthcare And Stem: Evaluation Of Case Studies, Yumna Indorewala, Santanu De

Trick to the Treat of Internships and Research

The zoonotic novel coronavirus has posed major challenges to the world’s economy, social development, and public health. Effects in the education and research in the field of healthcare and STEM are accentuated in lower-developed countries or communities where the access to technology and a reliable internet connection are luxuries making it difficult to attain education virtually. The Coronavirus Infectious Disease 2019 (COVID-19) has also disrupted research and training in STEM and healthcare. With significant increases in infection rates there is an urge to redirect projects towards virology research and vaccine development. This comprehensive literature review includes case studies highlighting the …

Global Research In Anatomy And Physiology During Covid-19: Lessons Learnt And Future Recommendations, Harsh Chheda, Jeet Patel, Santanu De

Trick to the Treat of Internships and Research

The ongoing Coronavirus Infectious Disease 2019 (COVID-19) pandemic has caused a significant disruption in several areas of research within the fields of Anatomy and Physiology. With the whole world coming to a standstill, research of any kind was difficult to pursue, especially in these disciplines requiring kinesthetic/tactile application of concepts or testing hypotheses through hands-on engagement, as the new social guidelines and risks to certain groups of people hindered up-to-date research-data collection. However, with new technology and protocols created or adopted, there has been an effort to better help students and scientists to conduct research remotely; such alternatives cannot effectively …

Summer 2022 Biology Internship: Medical University Of Graz, Austria, Sruthi Kundur, Maria Paula Farez

Trick to the Treat of Internships and Research

This internship was a 6 week internship program in Graz, Austria at the Medical University of Graz. This program allows for intercampus and institutional interaction in multiple scientific research disciplines whereby young scientists gain exposure, direction and guidance during their developing career paths. During the internship you will be to assist a transplant surgical team. Additionally, you can assist Dr. Philipp Siegler in their mini project.

Md Anderson Cancer Center Summer Experience, Lijo Andrews, Sachita Guthula

Trick to the Treat of Internships and Research

Given that there still exist cancers that are unresponsive to immunotherapy, high linear energy transfer (LET) radiation offers an alternative solution to bolstering anti-tumor immunity. Linear energy transfer is energy transferred per unit distance. Alpha particles have higher LET than other forms of radiotherapy and can create clustered DNA lesions. A possible component of these lesions is micronuclei, cytoplasmic DNA that can stimulate downstream immunostimulatory mechanisms. Because alpha particles cannot travel far, we utilized diffusing alpha-emitters radiation therapy (DaRT) to diffuse the alpha particles over a larger tumor volume. This occurs through the decay of the radium-224 seed, which forms …

Trick To The Treat Of Internships And Research: Health Literacy Project: Awareness Of Autism In Black And Brown Communities, Varun Kota, Mark Jaffe

Trick to the Treat of Internships and Research

Autism Spectrum Disorder (ASD) affects a multitude of races and ethnicities as its impact varies from person to person. ASD is typically diagnosed around the age of two to three years old since signs and symptoms of Autism develop then. Increased reporting of Autism in local communities has surged because of better diagnostic tools and criteria as well as public awareness. However, even with these advancements, the African American community suffers a delayed diagnosis for ASD. This issue poses problems for both the parents and children with Autism; opportunities are limited for developmental services by a delayed diagnosis. A literature …

Sea-Phages Research Opportunity, Sarah Ballarin

Trick to the Treat of Internships and Research

Research opportunity targeted for freshmen and sophomores through the SEA-PHAGES program. The goal of the research is to discover new bacteriophages (viruses that infect bacteria) to help combat antibiotic resistance. Phage therapy is a promising alternative to conventional antibiotics. Phages have also been widely used in the food industry to prevent microbial growth on certain foods and are currently being explored as a method for bioremediation of oil spills and wastewater treatment.

Last year, my research team discovered two new bacteriophages: Genamy16 and NovaSharks that were able to infect the bacteria Gordonia rubripertincta. These phages can possibly be used for …

Global Education In Anatomy And Physiology During Covid-19: Lessons Learnt And Future Recommendations, Sean Mahajan, Sneh Patel, Santanu De

Trick to the Treat of Internships and Research

The Coronavirus Infectious Disease 2019 (COVID-19) pandemic has disrupted several essential aspects of anatomy and physiology education worldwide. With this pandemic, dynamic instructional and technological interventions have been taking place rapidly in an effort to minimize the adverse repercussions of moving away from the traditional means of education in these critical scientific disciplines. COVID-19 has necessitated higher educational administrations, faculty, and students to pursue teaching, learning, and assessment of anatomy and physiology courses/curricula through innovative strategies without compromising on the quality or rigor of education. Our study encapsulates, for the first time, globally published reports on the key implications of …

Trick To The Treat: Penn Medicine Princeton Health Hospital, Divya Papaiya

Trick to the Treat of Internships and Research

I participated in the volunteering program of Penn Medicine Princeton Health over this summer from May to August. There are multiple departments you have the chance to volunteer in, but I was placed in the Peri-Operative Unit (pre and post-surgery unit). Volunteering allowed me to gain bedside manners by helping to serve and discharge patients while also letting me learn how day-to-day tasks in a hospital are run and how important it is to be dedicated in providing the best care possible to all people who walk through the hospital doors seeking aid.

Stem-Away: Mentor Chains Internships, Isha K. Pasumarthi

Trick to the Treat of Internships and Research

Mission: Helping students discover the potential & beauty of STEM, the joy of problem-solving and a STEM career that resonates with them.

Practicum In Biology, Alina Poothurail

Trick to the Treat of Internships and Research

The Practicum in Biology Course is a unique course which will help you develop essential skills for the advancement of your professional development. With various different assignments, you will learn how to conduct literature reviews, analyze research studies, and give excellent Journal Club Presentations. In addition, this course will prepare you for graduate school and the workforce as a result of conducting mock interviews, revising or creating your resume, and creating a personal statement or Cover Letter with the help of Nova Southeastern University’s Career Development Office. All components of this course were designed to provide you excel in your …

Research Internship At Marcus Neuroscience Institute, Abhinav Ankem

Trick to the Treat of Internships and Research

My internship experience at the Baptist Health Marcus Neuroscience Institute allowed me to pursue an opportunity in researching neuro inflammation with specific types of strokes and injuries resulting from impaired blood flow to the brain. I work with data from the lab, and with analyzing multiple pieces of literature for a greater understanding of the topics of interest in the lab. Lastly, I work with the staff and principal investigator to confirm my findings and work ahead on the data analysis.

Science Alive, Trisha Sudhakar, Rajin Persaud

Trick to the Treat of Internships and Research

The goal of Science Alive is to provide a “sense of wonder” not only for the grade-school children but for the college students and their faculty as well. Science Alive serves to reinforce the scientific knowledge of local grade-school students and community members, while enhancing the education and career development opportunities for college students. Our group does this by providing opportunities for youth to explore science beyond the textbooks through hands-on, interactive discovery, which stimulates interest and fosters confidence for college and grade-school students alike. Our groups lead on-campus and in-class workshops, weekend clubs, after-school programs, and other community events. …

Pfizer Summer Growth Experience, Arman Kakkar

Trick to the Treat of Internships and Research

From May 9, 2022 till July 29, 2022, I served as a Research Intern at Pfizer. Specifically, I worked in the Vaccine Research and Development Sector in the High Throughput Clinical Immunoassays and Diagnostics Group (HCID). In this group, I was responsible for Phase 3 testing of clinical trial material for the Covid-19 Vaccine. Over this time, I learned a great deal about the process of vaccine production from start to finish. Additionally, I was able to make numerous connections. This is definitely an experience I would recommend to others.

Independent Study (Biol 4990): Global Implications Of Covid-19 On Education And Research In Stem And Healthcare: Analysis Of Case Studies, Yumna Indorewala

Trick to the Treat of Internships and Research

The zoonotic novel coronavirus presents as a major challenge to the world’s economy, social development, and public health. Effects in the education and research in the field of healthcare and STEM are accentuated in lower-developed countries or communities where the access to technology and a reliable internet connection are luxuries making it difficult to attain education virtually. COVID-19 has also disrupted research and training in STEM and healthcare. With significant increases in infection rates there is an urge to redirect projects towards virology research and vaccine development. This comprehensive literature review includes case studies highlighting the consequences of COVID-19 on …

Trick To The Treat: Protein Modeling, Pujita Julakanti

Trick to the Treat of Internships and Research

Protein Modeling is a unique way of understanding a protein and its interactions. In this specific experience, students can find a protein that is interesting to them. Then, they can use protein visualization software such as Jmol and PyMOL to be able to see the structure better. They could write scripts in which they change parts of the protein for enhancement or simply to visualize the protein interactions. Overall, it is a great way to get involved in research. Luckily for NSU students, there is an Honors Intro to Protein Modeling course they can take with Dr. Schmitt and Dr. …

Bacteria Unearthed, Varsha Chigurupati, Mark Sourial, Katrina Maktaz, Alana Bertrand

Trick to the Treat of Internships and Research

Bacteria Unearthed is an NSU initiative to bring together high school and college students to participate in Tiny Earth: an international consortium of researchers searching for novel microorganisms and antibiotics to combat antibiotic drug resistance.

2022-10-26_Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services

Michigan COVID-19 Hospital Data

Contains the tables Statewide Hospital Capacity Report for COVID-19, COVID-19 Metrics, Statewide Hospital Available PPE Tracking for COVID-19, as well as the tables PPE Days On Hand and Patient Census.

2022-10-26_Michiganoverview_Covidvaccinestats, Michigan Department Of Health & Human Services

Michigan COVID-19 Vaccine Data

The COVID Vaccine Dashboard page was obtained from Michigan's main COVID-19 page: https://www.michigan.gov/coronavirus/resources/covid-19-vaccine/covid-19-dashboard.

First-dose tracker above is for entire Michigan Population. Coverage maps below are for age 5+.

Previously reported numbers of administered vaccine doses may change as new data are received. A possible lag in reporting vaccine doses will result in increases in numbers previously reported.

This report is created by the Michigan Department of Health and Human Services Division of Immunization from data reported to the Michigan Care Improvement Registry (MCIR).

The dashboard contained the tabs Primary Series Doses Administered, Primary Series Doses by Vaccine, …

2022 Celebration Of Scholarship, Creativity, And Engagement, Todd Bruns, Beth Heldebrandt

Programs

At this annual celebration, the entire Division of Academic Affairs is pleased that the important work of faculty continues and evolves as EIU’s professors have individually and collectively redefined the boundaries of scholarship, creativity, and innovation for the emerging post-COVID era. Indeed, we are excited to come together to celebrate the achievements and outstanding contributions of our colleagues and students to their disciplines and professions. And, as the following pages illustrate, faculty have engaged in continuing scholarly and creative activities that have provided outstanding mentoring experiences for our undergraduate and graduate students.

In addition to sharing faculty productivity, research excellence …

Poststroke Seizure And Epilepsy: A Review Of Incidence, Risk Factors, Diagnosis, Pathophysiology, And Pharmacological Therapies, Joseph Phan, Mario Ramos, Theodore Soares, Mayur S. Parmar

HPD Articles

Stroke is the most common cause of epilepsy and ultimately leads to a decrease in the quality of life of those affected. Ischemic and hemorrhagic strokes can both lead to poststroke epilepsy (PSE). Significant risk factors for PSE include age less than 65 years, stroke severity measured by the National Institutes of Health Stroke Scale (NIHSS), cortical involvement, and genetic factors such as TRPM6 polymorphism. The diagnosis of PSE is made by using imaging modalities, blood biomarkers, and prognostic criteria. Electroencephalography (EEG) is currently the gold standard to diagnose PSE, while new combinations of modalities are being tested to increase …