Medicine and Health Sciences Commons^™

The Importance Of An Early Onset Of Migraine Preventive Disease Control: A Roundtable Discussion, Christopher Gottschalk, Anirban Basu, Andrew Blumenfeld, Bradley Torphy, Michael J. Marmura, Jelena M. Pavlovic, Paula K. Dumas, Nim Lalvani, Dawn C. Buse

Department of Jefferson Headache Center Papers and Presentations

Background: Newly approved migraine preventive therapies have allowed for rapid control of migraine activity, offering potential to minimize the burden of migraine. This report summarizes a roundtable discussion convened to analyze evidence for early onset of prevention, ascertain its clinical relevance, and provide guidance for healthcare professionals in crafting goals and treatment expectations for patients with migraine initiating preventive therapy.

Methods: A virtual roundtable meeting of migraine clinicians, researchers, and patient advocates convened in October 2020. Participants reviewed and discussed data summarizing patient and healthcare professional perceptions of migraine prevention and evidence from the peer-reviewed and gray literature to develop …

Strategi Promosi Medical Check-Up Covid-19 Rsud Matraman, Vellyana Gustik, Wahyu Sulistiadi

Jurnal ARSI : Administrasi Rumah Sakit Indonesia

The community's need for health services during the Coronavirus Disease (COVID-19) pandemic has increased drastically. The need for health services at the hospital level includes examining and issuing a COVID-19 examination certificate. Responding to this, the Matraman Hospital incidentally created a new service, the COVID-19 Medical Check-Up (MCU). The management of RSUD Matraman realizes the importance of a promotional strategy to increase public interest in using the new service. This study aims to obtain an overview of the MCU COVID-19 service promotion strategy at the Matraman Hospital. The case study design in this study uses qualitative methods with in-depth interviews …

Rencana Strategi Pemasaran Rumah Sakit Saat Pandemi Covid-19 (Studi Kasus Rs Xyz Di Bogor), Makassari Dewi

Jurnal ARSI : Administrasi Rumah Sakit Indonesia

The COVID-19 pandemic has changed the behavior of hospital organizations in medical services and patient behavior. This encourages the hospitals to develop specific strategies to restore patient trust by providing a sense of security for patients and customers to obtain hospital services during the COVID-19 pandemic. The purpose of this study is to formulate the design of hospital marketing strategy of XYZ Hospital Bogor during the COVID-19 pandemic. This research method is descriptive qualitative with a case study approach in the XYZ Hospital Bogor using triangulation methods. The results was XYZ Hospital Bogor developed Telemedicine and digital marketing services as …

Genetic Correlation And Causality Assessment Between Post-Traumatic Stress Disorder And Coronary Artery Disease-Related Traits, Wole Akosile, Emmanuel Adewuyi

Research outputs 2022 to 2026

Consistent evidence from observational studies supports a risk-increasing association between post-traumatic stress disorder (PTSD) and coronary artery disease (CAD); however, the mechanisms underlying their relationship remain poorly understood. This study assesses the genetic correlation and potential causal relationship between PTSD and CAD-related traits. We analysed genome-wide associated study summary data of PTSD (cases = 23,212, controls = 151,447) with CAD-related traits (sample size up to 408,458 individuals) to achieve our study objectives. Findings revealed a significant and positive genetic correlation between PTSD and CAD (rG = 0.19, p = 3.47 × 10 – 2), and between PTSD and CAD traits …

Terminase Subunits From The Pseudomonas-Phage E217, Ravi K Lokareddy, Chun-Feng David Hou, Steven G Doll, Fenglin Li, Richard E Gillilan, Francesca Forti, David S Horner, Federica Briani, Gino Cingolani

Department of Biochemistry and Molecular Biology Faculty Papers

Pseudomonas phages are increasingly important biomedicines for phage therapy, but little is known about how these viruses package DNA. This paper explores the terminase subunits from the Myoviridae E217, a Pseudomonas-phage used in an experimental cocktail to eradicate P. aeruginosa in vitro and in animal models. We identified the large (TerL) and small (TerS) terminase subunits in two genes ∼58 kbs away from each other in the E217 genome. TerL presents a classical two-domain architecture, consisting of an N-terminal ATPase and C-terminal nuclease domain arranged into a bean-shaped tertiary structure. A 2.05 Å crystal structure of the C-terminal domain revealed …

Assessment And Prevention Of Bacterial Regrowth In Stored Household Water In Eastern Coastal Madagascar, Lauren Judah

USF Tampa Graduate Theses and Dissertations

As of 2020, diarrheal diseases were the leading cause of death in Madagascar. A major cause of diarrheal illness is contaminated water, and one crucial aspect of preventing contaminated water is safe household storage. Bacterial regrowth between point-of-collection and household storage has been well established in literature. A frequently implicated source of regrowth is the storage container’s biofilm, which is a community of varying bacteria enclosed in a “slimy” extracellular polymeric substance that forms on surfaces in wet environments and anchors bacteria to those surfaces. The overall goal of this thesis was to quantify and control bacterial regrowth in household …

Quantification Of Pulmonary Artery Configuration After The Arterial Switch Operation: A Pilot Study, Thomas Martens, Gillian Claeys, Joachim De Groote, Meletios Kanakis, Martin Kostolny, Victor Tsang, Marina Hughes

Faculty, Staff and Student Publications

BACKGROUND: The arterial switch operation (ASO) is the preferred treatment for d-transposition of the great arteries (TGA). Freedom from reintervention is mainly determined by the performance of the arterial outflow tracts, with variable incidence of pulmonary artery stenosis (PAS), possibly related to aspects of surgical technique. This pilot study attempts to describe pulmonary artery (PA) configuration through several measurements using three-dimensional data from cardiac magnetic resonance (CMR) imaging and assesses whether PA configuration is associated with PAS.

METHODS: A retrospective, single-centre analysis of paediatric patients undergoing CMR after ASO. The geometry of the pulmonary arteries was compared between patients with …

Perilaku Petugas Medis Dalam Merujuk Pasien Antenatal Care (Anc) Ke Rumah Sakit, Siti Hardina, Haerawati Idris

Jurnal ARSI : Administrasi Rumah Sakit Indonesia

High referrals can increase hospital workloads and result in increased claims costs to BPJS Health. The purpose of this study was to determine the behavior of health center staff in referring antenatal care patients to hospitals. The research method uses a descriptive qualitative design with a health belief model approach. Informants were selected using a purposive technique. Data were collected using an in-depth interview guide, observation, and document review in one of the primary health care in Palembang City. Data validation is done using the triangulation of sources, methods, and data. This study uses content analysis as a data analysis …

Sustainable Management Of Sewage Pollution From Ships In Duoala Port : Perspective On Challenges And Opportunities, Virginie Corinne Nguemche Ngajuissi Epse Moukoury

World Maritime University Dissertations

No abstract provided.

Availability Of Sugar-Sweetened Beverages At Home As The Dominant Factor Related To Its Consumption Among Students Of Sman (State High School) 47 Jakarta, Indonesia, In 2022, Nadhira Winindya Sari, Kusharisupeni Djokosujono, Diah Mulyawati Utari, Neni Rohayati

Indonesian Journal of Public Health Nutrition (IJPHN)

Sugar-sweetened beverages (SSBs) are drinks added with simple sugar, which can increase the energy because of calorie-dense and high in sugar, but low in other nutrients. Excessive consumption of SSBs can cause nutritional problems, such as increasing the risk of overweight and obesity. This study aims to determine the relationship between SSBs consumption and various factor and the dominant factor of SSBs consumption among students of SMAN (State High School) 47 Jakarta in 2022. The cross-sectional study was conducted from November 2021 to June 2022 with 120 respondents. Primary data was taken using questionnaires and analyzed by univariate, bivariate (chi-square …

Analysis Of The Relationship Between Children's Characteristics, Family Characteristics, Food Intake, Eating Habits, And Disease History With Nutritional Status Of Under-Five Children Based On The Composite Index Of Anthropometric Failure In Karangkamulyan Village, Cihara District, Lebak Regency, Indonesia In 2020, Ayu Anisadiyah, Ratu Ayu Dewi Sartika

Indonesian Journal of Public Health Nutrition (IJPHN)

The Composite Index of Anthropometric Failure (CIAF) is an indicator of composite nutritional status assessment (BB/U, PB/U, and BB/PB) to describe all under-five children’s nutritional problems. In 2020, malnutrition, unemployment, and poverty in Banten Province were high, and the population's income tends to be low. Karangkamulyan Village is an underdeveloped village with mining areas. This study aims to determine the factors related to the nutritional status of under-five children based on CIAF in Karangkamulyan Village in 2020. The study used a cross-sectional study design and a systematic random sampling technique. The research sample was 141 under-five children aged 24-59 months. …

Sleep Quality And Affecting Factors Among Elderly Living In A Nursing Home In East Nusa Tenggara Indonesia, Asyifa Robiatul Adawiyah, Kusharisupeni Djokosujono, Jumiati Lelu Sanga

Indonesian Journal of Public Health Nutrition (IJPHN)

Sleep is one of the processes that greatly affects aging, It is essential for mental, physical, and maintenance of physical health. A research study was conducted in a public nursing home in Kupang East Nusa Tenggara Indonesia. This study aimed to analyze the sleep quality and the factors affecting sleep quality, among old age living in the nursing home. The research design was cross-sectional with primary data on 103 elderly living in nursing homes. There was a relationship between age, gender, marital status, spouse, educational background, have a chronic disease, living arrangement, anxiety, and depression with sleep quality (p

Factors Associated With High Fat, Salt, And Sugar Food Selection On Online Food Delivery Service Among Students Of Sman (State High School) 47 Jakarta, Indonesia, In 2022, Arifiana Arifiana, Kusharisupeni Djokosujono, Wahyu Kurnia Yusrin Putra, Nina Muziana

Indonesian Journal of Public Health Nutrition (IJPHN)

In the use of Online Food Delivery Service (OFDS), an online service applying a smartphone to make it easier for users to get food quickly, it was found that the foods selected tend to be unhealthy and may increase the risk of being overweight. The aim of this study was to determine predominant and other factors that differ in food selection in OFDS among students at SMAN (State High School) 47 Jakarta in 2022. This study applied a cross-sectional study design with 112 subjects. Data were taken through a questionnaire and analyzed by using an X²- test and multiple logistic …

The Association Between Feeding Practices And History Of Diarrhea With Nutritional Status Of Toddlers, Lulu Indria Setyani, Khoirul Anwar

Indonesian Journal of Public Health Nutrition (IJPHN)

The age of 0-59 months is a phase of basic life formation that is vulnerable to nutritional problems—causes such as infectious diseases and parenting. This research aims to analyze the relationship between feeding practices and a history of diarrhea with the nutritional status of children under five. This study used a cross-sectional design. Samples were taken by purposive sampling of as many as 96 toddlers. Data were collected by direct measurement of weight scales, stature meters, and interviews using the main questionnaire and the modified CFQ questionnaire. The statistical tests used were the chi-square test and fisher's exact test. A …

From Zoom To The Clinic: Unique Student Challenges In Physical Therapy Clinical Education, Amy Both, Jaclyn Catherine Carson, Matthew B. Garber, Heather Marie Mack, Nicole M. Sleddens

Posters and Presentations: Physical Therapy

While the abrupt shift in PT education (PTE) brought on by the pandemic created opportunities for educational innovation, it also brought relational separation and fragmented learning due to lockdowns, social distancing, face masks, and communication limited to virtual platforms. Academic programs increased use of virtual learning, rearranged curriculum, reduced lab and simulated learning time, and provided fewer, if any, opportunities for service learning and patient contact. Clinic sites paused clinic education experiences or hosted fewer students to maintain social distancing and limit disease exposure. As PTE returns to more typical curricular schedules and practices, it is important to be aware …

Developing A Virtual Global Dermatology Curriculum: Qualitative Analysis Based On A Pilot Study In Ethiopia, Rishab Revankar, Aditya Sood, Heli Patel, Kassahun Bilcha, Annisa Befekadu, Howa Yeung, Benjamin Stoff

Department of Dermatology and Cutaneous Biology Faculty Papers

No abstract provided.

Defining Cellular Complexity In Human Autosomal Dominant Polycystic Kidney Disease By Multimodal Single Cell Analysis, Yoshiharu Muto, Eryn E Dixon, Yasuhiro Yoshimura, Haojia Wu, Kohei Omachi, Nicolas Ledru, Parker C Wilson, Jeffrey H Miner, Benjamin D Humphreys, Et Al.

2020-Current year OA Pubs

Autosomal dominant polycystic kidney disease (ADPKD) is the leading genetic cause of end stage renal disease characterized by progressive expansion of kidney cysts. To better understand the cell types and states driving ADPKD progression, we analyze eight ADPKD and five healthy human kidney samples, generating single cell multiomic atlas consisting of ~100,000 single nucleus transcriptomes and ~50,000 single nucleus epigenomes. Activation of proinflammatory, profibrotic signaling pathways are driven by proximal tubular cells with a failed repair transcriptomic signature, proinflammatory fibroblasts and collecting duct cells. We identify GPRC5A as a marker for cyst-lining collecting duct cells that exhibits increased transcription factor …

Transient Hiatal Separation During Straight Leg Raise Can Predict Reflux Burden In Gastroesophageal Reflux Disease Patients With Ineffective Esophageal Motility, Wei-Yi Lei, Shu-Wei Liang, Taher Omari, Wei-Chuan Chang, Ming-Wun Wong, Jui-Sheng Hung, Chih-Hsun Yi, Tso-Tsai Liu, Lin Lin, C Prakash Gyawali, Chien-Lin Chen

2020-Current year OA Pubs

BACKGROUND/AIMS: Straight leg raise (SLR) can be utilized to evaluate the integrity of the esophagogastric junction during high-resolution manometry (HRM). We aim to assess the value of transient hiatal separation during SLR in symptomatic reflux patients.

METHODS: Consecutive reflux patients undergoing esophageal HRM and pH monitoring were included. Transient hiatal separation was defined by a ≥ 1 cm separation between the lower esophageal sphincter and crural diaphragm during SLR. We compared esophageal motor patterns and reflux monitoring parameters between patients with normal, transiently abnormal and consistently abnormal esophagogastric junction morphology during SLR.

RESULTS: Of 85 (56.3% female, mean age: 46.7 …

11th International Conference On Business, Technology And Innovation 2022, University For Business And Technology - Ubt

UBT International Conference

Welcome to IC – UBT 2022

UBT Annual International Conference is the 11th international interdisciplinary peer reviewed conference which publishes works of the scientists as well as practitioners in the area where UBT is active in Education, Research and Development. The UBT aims to implement an integrated strategy to establish itself as an internationally competitive, research-intensive university, committed to the transfer of knowledge and the provision of a world-class education to the most talented students from all background. The main perspective of the conference is to connect the scientists and practitioners from different disciplines in the same place and make …

Successful Long-Term Anticoagulation With Low Molecular Weight Heparin In A Patient With Mechanical Mitral Valve And Atrial Flutter, Narjis Aljaziri, Meshail Saleh Alkhaleel, Norah Alrajhi, Mohammed Alghamdi, Ahmed Aljizeeri

Journal of the Saudi Heart Association

Mechanical heart valves are associated with high risk of thrombosis and thromboembolic complications. Vitamin K antagonist is the only approved oral medication for the anticoagulation in cases of mechanical heart valves. This poses a challenge in cases where vitamin K antagonists are contraindicated. Although temporary anticoagulation with low molecular weight heparin is common among pregnant patients with mechanical heart valves, data about long term anticoagulation with low molecular weight heparin is limited. We report a successful long-term anticoagulation with low molecular weight heparin in a patient with mechanical mitral valve and atrial flutter.

Mirnas: The Key Regulator Of Covid-19 Disease, Leyla T. Hardin, Nan Xiao

Pacific Faculty Work

As many parts of the world continue to fight the innumerable waves of COVID-19 infection, SARS-CoV-2 continues to sculpt its antigenic determinants to enhance its virulence and evolvability. Several vaccines were developed and used around the world, and oral antiviral medications are being developed against SARS-CoV-2. However, studies showed that the virus is mutating in line with the antibody's neutralization escape; thus, new therapeutic alternatives are solicited. We hereby review the key role that miRNAs can play as epigenetic mediators of the cross-talk between SARS-CoV-2 and the host cells. The limitations resulting from the "virus intelligence"to escape and antagonize the …

Improv-Ing The Forensic Interview, Nina E. Ross, Karen B. Rosenbaum, Charles L. Scott, Jeffrey Guina, Kendall Genre

Conference Presentation Abstracts

No abstract provided.

Dating App Facilitated Sexual Assault: A Retrospective Review Of Sexual Assault Medical Forensic Examination Charts, Julie L. Valentine, Leslie W. Miles, Kristen Mella Hamblin, Aubrey Worthen Gibbons

Faculty Publications

Dating app facilitated sexual assault (DAppSA) is a concerning phenomenon with minimal published research. This retrospective study explored if DAppSAs were different than other sexual assaults (SAs) committed by acquaintances through a review of 3,413 sexual assault medical forensic examination (SAMFE) charts from 2017 to 2020 in a Mountain West state in the United States. Routine Activities Theory and Confluence Model of sexual aggression provided the theoretical framework for the study. Inclusion criteria for DAppSA cases included (1) victim was 14 years of age or older; (2) victim indicated meeting the perpetrator on a dating app; (3) SA occurred at …

Inhibition Of Colorectal Cancer Tumorigenesis By Ursolic Acid And Doxorubicin Is Mediated By Targeting The Akt Signaling Pathway And Activating The Hippo Signaling Pathway, Masashi Fujita, Mei-Ju May Chen, Doris Rieko Siwak, Shota Sasagawa, Ayako Oosawa-Tatsuguchi, Koji Arihiro, Atsushi Ono, Ryoichi Miura, Kazuhiro Maejima, Hiroshi Aikata, Masaki Ueno, Shinya Hayami, Hiroki Yamaue, Kazuaki Chayama, Ju-Seog Lee, Yiling Lu, Gordon B Mills, Han Liang, Satoshi S Nishizuka, Hidewaki Nakagawa

Faculty, Staff and Student Publications

Primary liver cancer is a heterogeneous disease in terms of its etiology, histology, and therapeutic response. Concurrent proteomic and genomic characterization of a large set of clinical liver cancer samples can help elucidate the molecular basis of heterogeneity and thus serve as a valuable resource for personalized liver cancer treatment. In this study, we perform proteomic profiling of ~300 proteins on 259 primary liver cancer tissues with reverse-phase protein arrays, mutational analysis using whole genome sequencing and transcriptional analysis with RNA-Seq. Patients are of Japanese ethnic background and mainly HBV or HCV positive, providing insight into this important liver cancer …

Proteo-Genomic Characterization Of Virus-Associated Liver Cancers Reveals Potential Subtypes And Therapeutic Targets, Masashi Fujita, Mei-Ju May Chen, Doris Rieko Siwak, Shota Sasagawa, Ayako Oosawa-Tatsuguchi, Koji Arihiro, Atsushi Ono, Ryoichi Miura, Kazuhiro Maejima, Hiroshi Aikata, Masaki Ueno, Shinya Hayami, Hiroki Yamaue, Kazuaki Chayama, Ju-Seog Lee, Yiling Lu, Gordon B Mills, Han Liang, Satoshi S Nishizuka, Hidewaki Nakagawa

Faculty, Staff and Student Publications

Primary liver cancer is a heterogeneous disease in terms of its etiology, histology, and therapeutic response. Concurrent proteomic and genomic characterization of a large set of clinical liver cancer samples can help elucidate the molecular basis of heterogeneity and thus serve as a valuable resource for personalized liver cancer treatment. In this study, we perform proteomic profiling of ~300 proteins on 259 primary liver cancer tissues with reverse-phase protein arrays, mutational analysis using whole genome sequencing and transcriptional analysis with RNA-Seq. Patients are of Japanese ethnic background and mainly HBV or HCV positive, providing insight into this important liver cancer …

Desmoglein-2 Is Important For Islet Function And Β-Cell Survival, Kay K. Myo Min, Darling Rojas-Canales, Daniella Penko, Mark Denichilo, Michaelia P. Cockshell, Charlie B. Ffrench, Emma J. Thompson, Olof Asplund, Christopher J. Drogemuller, Rashmi B. Prasad, Leif Groop, Shane T Grey, Helen E. Thomas, Thomas Loudovaris, Thomas W. Kay, My G. Mahoney, Claire F. Jessup, P. Toby Coates, Claudine S. Bonder

Department of Dermatology and Cutaneous Biology Faculty Papers

Type 1 diabetes is a complex disease characterized by the lack of endogenous insulin secreted from the pancreatic β-cells. Although β-cell targeted autoimmune processes and β-cell dysfunction are known to occur in type 1 diabetes, a complete understanding of the cell-to-cell interactions that support pancreatic function is still lacking. To characterize the pancreatic endocrine compartment, we studied pancreata from healthy adult donors and investigated a single cell surface adhesion molecule, desmoglein-2 (DSG2). Genetically-modified mice lacking Dsg2 were examined for islet cell mass, insulin production, responses to glucose, susceptibility to a streptozotocin-induced mouse model of hyperglycaemia, and ability to cure diabetes …

"We Start Where We Are": A Qualitative Study Of Barriers And Pragmatic Solutions To The Assessment And Reporting Of Implementation Strategy Fidelity, Christopher F Akiba, Byron J Powell, Brian W Pence, Kate Muessig, Carol E Golin, Vivian Go

2020-Current year OA Pubs

BACKGROUND: Fidelity measurement of implementation strategies is underdeveloped and underreported, and the level of reporting is decreasing over time. Failing to properly measure the factors that affect the delivery of an implementation strategy may obscure the link between a strategy and its outcomes. Barriers to assessing and reporting implementation strategy fidelity among researchers are not well understood. The aims of this qualitative study were to identify barriers to fidelity measurement and pragmatic pathways towards improvement.

METHODS: We conducted in-depth interviews among researchers conducting implementation trials. We utilized a theory-informed interview approach to elicit the barriers and possible solutions to implementation …

Discharge Process In Cvssu For Post-Pci Patients, Kristyn Gonzaga

St. Joseph Hospital, Orange, CA. Evidence Based Practice Conference

No abstract provided.

Improving Patient Communication Using Technology, Kim Duke

St. Joseph Hospital, Orange, CA. Evidence Based Practice Conference

No abstract provided.

Patient Satisfaction & Usgpiv, Joey Nguyen

St. Joseph Hospital, Orange, CA. Evidence Based Practice Conference

No abstract provided.