Medicine and Health Sciences Commons^™

The Programmed Death-1 Signaling Axis Modulates Inflammation And Lv Structure/Function In A Stress-Induced Cardiomyopathy Model, Tomohiro Hayashi, Sajal K Tiwary, Kory J Lavine, Sandeep Acharya, Michael Brent, Luigi Adamo, Attila Kovacs, Douglas L Mann

2020-Current year OA Pubs

The role of immune checkpoints in the setting of tissue injury remains unknown. Using an experimental model of isoproterenol (ISO)-induced stress cardiomyopathy, we show that ISO-induced myocardial injury provokes tissue-autonomous up-regulation of the programmed death-1 (PD-1):programmed death ligand (PD-L) axis in cardiac resident innate immune cells and T cells. PD-1 signaling was responsible for modulating the acute inflammatory response, as well as normalization of impaired left ventricular structure and function after ISO injection. Necrotic cardiac extracts were sufficient to increase the expression of PD-1 in macrophages and T cells in vitro. Viewed together these studies suggest that the PD-1:PD-L signaling …

Inositol Phosphorylceramide Synthase Null Leishmania Are Viable And Virulent In Animal Infections Where Salvage Of Host Sphingomyelin Predominates, F Matthew Kuhlmann, Phillip N Key, Suzanne M Hickerson, John Turk, Fong-Fu Hsu, Stephen M Beverley

2020-Current year OA Pubs

Many pathogens synthesize inositol phosphorylceramide (IPC) as the major sphingolipid (SL), differing from the mammalian host where sphingomyelin (SM) or more complex SLs predominate. The divergence between IPC synthase and mammalian SL synthases has prompted interest as a potential drug target. However, in the trypanosomatid protozoan Leishmania, cultured insect stage promastigotes lack de novo SL synthesis (Δspt2

Peroxisomal Regulation Of Energy Homeostasis: Effect On Obesity And Related Metabolic Disorders, Brian Kleiboeker, Irfan J Lodhi

2020-Current year OA Pubs

BACKGROUND: Peroxisomes are single membrane-bound organelles named for their role in hydrogen peroxide production and catabolism. However, their cellular functions extend well beyond reactive oxygen species (ROS) metabolism and include fatty acid oxidation of unique substrates that cannot be catabolized in mitochondria, and synthesis of ether lipids and bile acids. Metabolic functions of peroxisomes involve crosstalk with other organelles, including mitochondria, endoplasmic reticulum, lipid droplets and lysosomes. Emerging studies suggest that peroxisomes are important regulators of energy homeostasis and that disruption of peroxisomal functions influences the risk for obesity and the associated metabolic disorders, including type 2 diabetes and hepatic …

Self-Care Management Of Bothersome Symptoms As Recommended By Clinicians For Patients With A Chronic Condition: A Delphi Study, Heleen Westland, Shayleigh Dickson Page, Michelle Van Rijn, Subhash Aryal, Kenneth E Freedland, Christopher Lee, Anna Strömberg, Ercole Vellone, Douglas J Wiebe, Tiny Jaarsma, Barbara Riegel

2020-Current year OA Pubs

BACKGROUND: Chronically medically ill patients often need clinical assistance with symptom management, as well as self-care interventions that can help to reduce the impact of bothersome symptoms. Experienced clinicians can help to guide the development of more effective self-care interventions.

OBJECTIVE: To create a consensus-based list of common bothersome symptoms of chronic conditions and of self-care management behaviors recommended to patients by clinicians to reduce the impact of these symptoms.

METHODS: A two-round Delphi study was performed among an international panel of 47 clinicians using online surveys to identify common and bothersome symptoms and related self-care management behaviors recommended to …

Guidance For The Diagnosis And Treatment Of Hypolipidemia Disorders, Cindy Bredefeld, Nicholas O Davidson, Et Al.

2020-Current year OA Pubs

The Abetalipoproteinemia and Related Disorders Foundation was established in 2019 to provide guidance and support for the life-long management of inherited hypocholesterolemia disorders. Our mission is "to improve the lives of individuals and families affected by abetalipoproteinemia and related disorders". This review explains the molecular mechanisms behind the monogenic hypobetalipoproteinemia disorders and details their specific pathophysiology, clinical presentation and management throughout the lifespan. In this review, we focus on abetalipoproteinemia, homozygous hypobetalipoproteinemia and chylomicron retention disease; rare genetic conditions that manifest early in life and cause severe complications without appropriate treatment. Absent to low plasma lipid levels, in particular cholesterol …

To Calibrate Or Not To Calibrate? A Methodological Dilemma In Experimental Pain Research, Waclaw M Adamczyk, Tibor M Szikszay, Hadas Nahman-Averbuch, Jacek Skalski, Jakub Nastaj, Philip Gouverneur, Kerstin Luedtke

2020-Current year OA Pubs

To calibrate or not to calibrate? This question is raised by almost everyone designing an experimental pain study with supra-threshold stimulation. The dilemma is whether to individualize stimulus intensity to the pain threshold / supra-threshold pain level of each participant or whether to provide the noxious stimulus at a fixed intensity so that everyone receives the identical input. Each approach has unique pros and cons which need to be considered to i) accurately design an experiment, ii) enhance statistical inference in the given data and, iii) reduce bias and the influence of confounding factors in the individual study e.g., body …

Local Failure Events In Prostate Cancer Treated With Radiotherapy: A Pooled Analysis Of 18 Randomized Trials From The Meta-Analysis Of Randomized Trials In Cancer Of The Prostate Consortium (Leviathan), Ting Martin Ma, Jeff M Michalski, Et Al.

2020-Current year OA Pubs

CONTEXT: The prognostic importance of local failure after definitive radiotherapy (RT) in National Comprehensive Cancer Network intermediate- and high-risk prostate cancer (PCa) patients remains unclear.

OBJECTIVE: To evaluate the prognostic impact of local failure and the kinetics of distant metastasis following RT.

EVIDENCE ACQUISITION: A pooled analysis was performed on individual patient data of 12 533 PCa (6288 high-risk and 6245 intermediate-risk) patients enrolled in 18 randomized trials (conducted between 1985 and 2015) within the Meta-analysis of Randomized Trials in Cancer of the Prostate Consortium. Multivariable Cox proportional hazard (PH) models were developed to evaluate the relationship between overall survival …

Pembrolizumab For Patients With Non-Hodgkin Lymphoma: Phase 1b Keynote-013 Study, John Kuruvilla, Nancy L Bartlett, Et Al.

2020-Current year OA Pubs

The multicohort phase 1b KEYNOTE-013 study (NCT01953692) evaluated the safety and efficacy of pembrolizumab in patients with relapsed or refractory NHL who were ineligible for or failed hematopoietic cell transplantation (HCT). Patients received pembrolizumab (cohort 4) or pembrolizumab plus lenalidomide (cohort 5). Primary end points were safety and objective response rate (ORR) per IWG 2007 criteria. Cohort 4 included 89 patients. ORR was 22% (19/86; 90% CI 15-31; 10 CR, nine PR); ORRs by disease type were 48% (10/21), 10% (2/20), 12% (5/41), and 50% (2/4), for PMBCL, FL, DLBCL, and 'other' NHL, respectively. Toxicity was as predicted. Cohort 5 …

Genome-Wide Meta-Analysis For Alzheimer's Disease Cerebrospinal Fluid Biomarkers, Iris E Jansen, Muhammad Ali, Yun Ju Sung, Carlos Cruchaga, Duber Gomez-Fonseca, Et Al.

2020-Current year OA Pubs

Amyloid-beta 42 (Aβ42) and phosphorylated tau (pTau) levels in cerebrospinal fluid (CSF) reflect core features of the pathogenesis of Alzheimer's disease (AD) more directly than clinical diagnosis. Initiated by the European Alzheimer & Dementia Biobank (EADB), the largest collaborative effort on genetics underlying CSF biomarkers was established, including 31 cohorts with a total of 13,116 individuals (discovery n = 8074; replication n = 5042 individuals). Besides the APOE locus, novel associations with two other well-established AD risk loci were observed; CR1 was shown a locus for Aβ42 and BIN1 for pTau. GMNC and C16orf95 were further identified as loci for …

Ventilation Strategies During Extracorporeal Membrane Oxygenation For Neonatal Respiratory Failure: Current Approaches Among Level Iv Neonatal Icus, John Ibrahim, Rakesh Rao, Et Al.

2020-Current year OA Pubs

UNLABELLED: To describe ventilation strategies used during extracorporeal membrane oxygenation (ECMO) for neonatal respiratory failure among level IV neonatal ICUs (NICUs).

DESIGN: Cross-sectional electronic survey.

SETTING: Email-based Research Electronic Data Capture survey.

PATIENTS: Neonates undergoing ECMO for respiratory failure at level IV NICUs.

INTERVENTIONS: A 40-question survey was sent to site sponsors of regional referral neonatal ECMO centers participating in the Children's Hospitals Neonatal Consortium. Reminder emails were sent at 2- and 4-week intervals.

MEASUREMENTS AND MAIN RESULTS: Twenty ECMO centers responded to the survey. Most primarily use venoarterial ECMO (65%); this percentage is higher (90%) for congenital diaphragmatic hernia. …

Distinct Stimulus-Dependent Neutrophil Dynamics Revealed By Real-Time Imaging Of Intestinal Mucosa After Acute Injury, Veronica Azcutia, Matthias Kelm, Seonyoung Kim, Anny-Claude Luissint, Sven Flemming, Lisa Abernathy-Close, Vincent B Young, Asma Nusrat, Mark J Miller, Charles A Parkos

2020-Current year OA Pubs

Clinical symptoms in many inflammatory diseases of the intestine are directly related to neutrophil (PMN) migration across colonic mucosa and into the intestinal lumen, yet in-vivo studies detailing this process are lacking. Using real-time intravital microscopy and a new distal colon loop model, we report distinct PMN migratory dynamics in response to several models of acute colonic injury. PMNs exhibited rapid swarming responses after mechanically induced intestinal wounds. Similar numbers of PMNs infiltrated colonic mucosa after wounding in germ-free mice, suggesting microbiota-independent mechanisms. By contrast, acute mucosal injury secondary to either a treatment of mice with dextran sodium sulfate or …

Brain Volume In Chronic Ketamine Users - Relationship To Sub-Threshold Psychotic Symptoms And Relevance To Schizophrenia, Robert A Chesters, Fiona Pepper, Celia Morgan, Jonathan D Cooper, Oliver D Howes, Anthony C Vernon, James M Stone

2020-Current year OA Pubs

RATIONALE: Ketamine may model aspects of schizophrenia arising through NMDA receptor activity deficits. Although acute ketamine can induce effects resembling both positive and negative psychotic symptoms, chronic use may be a closer model of idiopathic psychosis.

OBJECTIVES: We tested the hypotheses that ketamine users had lower brain volumes, as measured using MRI, and greater sub-threshold psychotic symptoms relative to a poly-drug user control group.

METHODS: Ketamine users (n = 17) and poly-drug using controls (n = 19) were included in the study. All underwent volumetric MRI imaging and measurement of sub-threshold psychotic symptoms using the Comprehensive Assessment of At-Risk Mental …

The Serotonin Receptor 3e Variant Is A Risk Factor For Female Ibs-D, Nikola Fritz, Gregory Sayuk, Et Al.

2020-Current year OA Pubs

Irritable bowel syndrome (IBS) is a gut-brain disorder of multifactorial origin. Evidence of disturbed serotonergic function in IBS accumulated for the 5-HT

Risk-Adjusted Safety Analysis Of The Oral Jak2/Irak1 Inhibitor Pacritinib In Patients With Myelofibrosis, Naveen Pemmaraju, Claire Harrison, Vikas Gupta, Srdan Verstovsek, Bart Scott, Stephen T Oh, Francesca Palandri, Haifa Kathrin Al-Ali, Marta Sobas, Mary Frances Mcmullin, Ruben Mesa, Sarah Buckley, Karisse Roman-Torres, Alessandro Vannucchi, Abdulraheem Yacoub

2020-Current year OA Pubs

The safety profile of the novel oral JAK2/IRAK1 inhibitor pacritinib in patients with cytopenic myelofibrosis was described in the Phase 2 PAC203 and Phase 3 PERSIST-2 studies. To account for longer treatment durations on the pacritinib arms compared to best available therapy (BAT), we present a risk-adjusted safety analysis of event rates accounting for different time on treatment. While the rate of overall events was higher on pacritinib compared to BAT, the rate of fatal events was lower, and there was no excess in bleeding, cardiac events, secondary malignancy, or thrombosis on pacritinib, including in patients with severe thrombocytopenia.

Investigating The Role Of Irc20 And Cdc48 In The Maintenance Of Yeast Genome, Asma Albadi Alnuaimi

Theses

DNA, the basic unit of inheritance, is continuously exposed to numerous endogenous and exogenous damaging agents that compromise its function and adversely impact health. However, the cell has evolved intricate DNA repair mechanisms to mitigate the negative consequences of genomic instability. The repair of DNA double-strand break (DSB) is potentially accomplished by various mechanisms, including homologous recombination (HR). An HR-mediated DSB repair requires controlled regulation of repair proteins to ensure timely function. Posttranslational modifications (PTMs), such as ubiquitylation and SUMOylation, are regulatory mechanisms that significantly fine-tune proteins activities. Central to these processes is Rad52, a conserved oligomeric protein that forms …

Everyday Life With Childhood Functional Constipation: A Qualitative Phenomenological Study Of Parents' Experiences, Gunilla Flankegård, Evalotte Mörelius, Patrik Rytterström

Research outputs 2022 to 2026

Childhood functional constipation (FC) is a worldwide problem with treatment regiments affecting everyday life. Aim: To explore parents´ experiences of living with a child with FC and its impact on everyday family life. Method: A qualitative phenomenological interview study using a reflective lifeworld research approach. Interviews with 15 parents of otherwise healthy children aged 1–14 years affected by FC. Findings: Shame is the driving force making parents put everyday life on hold. The quest for control, self-imposed loneliness, guilt, inadequacy, and frustrating battles become essential parts of everyday life to protect it from FC-related shame. Conclusion: FC has as great …

Apoe Ε2 Resilience For Alzheimer’S Disease Is Mediated By Plasma Lipid Species: Analysis Of Three Independent Cohort Studies, Tingting Wang, Kevin Huynh, Corey Giles, Natalie A. Mellett, Thy Duong, Anh Nguyen, Wei L. F. Lim, Alex A. T. Smith, Gavriel Olshansky, Gemma Cadby, Joseph Hung, Jennie Hui, John Beilby, Gerald F. Watts, Pratishtha Chatterjee, Ian Martins, Simon Laws, Ashley I. Bush, Christopher C. Rowe, Victor L. Villemagne, David Ames, Colin L. Masters, Kevin Taddei, Vincent Doré, Jürgen Fripp, Matthias Arnold, Gabi Kastenmüller, Kwangsik Nho, Andrew J. Saykin, Rebecca Baillie, Xianlin Han, Ralph N. Martins, Eric K. Moses, Rima Kaddurah-Daouk, Peter J. Meikle

Research outputs 2022 to 2026

Introduction:

The apolipoprotein E (APOE) genotype is the strongest genetic risk factor for late-onset Alzheimer's disease. However, its effect on lipid metabolic pathways, and their mediating effect on disease risk, is poorly understood.

Methods:

We performed lipidomic analysis on three independent cohorts (the Australian Imaging, Biomarkers and Lifestyle [AIBL] flagship study, n = 1087; the Alzheimer's Disease Neuroimaging Initiative [ADNI] 1 study, n = 819; and the Busselton Health Study [BHS], n = 4384), and we defined associations between APOE ε2 and ε4 and 569 plasma/serum lipid species. Mediation analysis defined the proportion of the treatment effect of the APOE …

Monitoring Quality Of Care In Hepatocellular Carcinoma: A Modified Delphi Consensus, Ashika D. Maharaj, John Lubel, Eileen Lam, Paul J. Clark, Oliver Duncan, Jacob George, Gary P. Jeffrey, Lara Lipton, Howard Liu, Geoffrey Mccaughan, Eu-Ling Neo, Jennifer Philip, Simone I. Strasser, Katherine Stuart, Alexander Thompson, Jonathan Tibballs, Thomas Tu, Michael C. Wallace, Alan Wigg, Marnie Wood, Amany Zekry, Elysia Greenhill, Liane J. Ioannou, Golo Ahlenstiel, Kaye Bowers, Stephen J. Clarke, Anouk Dev, Michael Fink, Mark Goodwin, Christos S. Karapetis, Miriam T. Levy, Kate Muller, James O'Beirne, David Pryor, James Seow, Nicholas Shackel, Caroline Tallis, Nick Butler, John K. Olynyk, Kate Reed-Cox, John R. Zalcberg, Stuart K. Roberts

Research outputs 2022 to 2026

Although there are several established international guidelines on the management of hepatocellular carcinoma (HCC), there is limited information detailing specific indicators of good quality care. The aim of this study was to develop a core set of quality indicators (QIs) to underpin the management of HCC. We undertook a modified, two-round, Delphi consensus study comprising a working group and experts involved in the management of HCC as well as consumer representatives. QIs were derived from an extensive review of the literature. The role of the participants was to identify the most important and measurable QIs for inclusion in an HCC …

Investigations Of The Potential Use Of Macrophages In Gastric Stem Cell Activation/Differentiation And Ulcer Healing, Subi Sugathan

Dissertations

Stomach erosions and ulcerations are common health problems, and their therapy requires tissue regeneration. While current therapy for these disorders focuses on targeting parietal cells to inhibit acid secretion, the role of stem cells in the regeneration process is neglected. In this study, the aim is to investigate the potential use of macrophages to activate gastric stem cells in co-culture experiments and in a mouse model of gastric ulcer. Bone marrow-derived macrophages were prepared and cultured in the presence of lipopolysaccharides and interleukin-4 to, respectively, induce their differentiation into pro-inflammatory (M1) and anti-inflammatory (M2) macrophages. Polarization of these phenotypes was …

Gestational Diabetes Mellitus Screening, Diagnosis And Knowledge In The United Arab Emirates, Maryam Mohammed Bashir

Dissertations

Gestational diabetes mellitus (GDM) is a significant public health problem with short- and long-term consequences. If undiagnosed and untreated, it is associated with multiple adverse perinatal outcomes and future risk of developing type 2 diabetes mellitus (DM) and other cardiovascular diseases in affected mothers and children. In the United Arab Emirates (UAE), up to 1 in 4 pregnancies are affected by GDM. This PhD dissertation explores GDM screening, diagnosis, guideline use, and knowledge to provide a basis for primordial, primary, secondary, and tertiary levels of prevention in GDM care in the UAE. Three studies were conducted to achieve the PhD …

On-Field Deployment And Validation For Wearable Devices, Calvin Kuo, Declan Patton, Tyler Rooks, Gregory Tierney, Andrew Mcintosh, Robert Lynall, Amanda Esquivel, Ray Daniel, Thomas Kaminski, Jason Mihalik, Nate Dau, Jillian Urban

Research outputs 2022 to 2026

Wearable sensors are an important tool in the study of head acceleration events and head impact injuries in sporting and military activities. Recent advances in sensor technology have improved our understanding of head kinematics during on-field activities; however, proper utilization and interpretation of data from wearable devices requires careful implementation of best practices. The objective of this paper is to summarize minimum requirements and best practices for on-field deployment of wearable devices for the measurement of head acceleration events in vivo to ensure data evaluated are representative of real events and limitations are accurately defined. Best practices covered in this …

The Potent And Selective Histamine H3 Receptor Antagonist E169 Alleviates Cognitive Deficits And Mitigates Disturbed Pi3k/Akt/Gsk-3Β Signaling Pathway In Mk801-Induced Amnesia In Mice, Sabna Tagelsir Hassan Abdalla

Theses

The role of Histamine H3 Receptors (H3Rs) in memory and the prospective of H3R antagonists in pharmacological control of neurodegenerative disorders, e.g., Alzheimer’s Disease (AD) is well-accepted. Therefore, the procognitive effects of acute systemic administration of H3R antagonist E169 (2.5-10 mg/kg, i.p.) on MK801- induced amnesia using the Novel Object Recognition Test (NORT) paradigm in C57BL/6J mice were evaluated. E169 (5 mg) provided a significant memory-improving effect on MK801-induced short- and long-term memory impairments in NORT. The E169 (5 mg) provided effects were comparable to those observed with the Phosphatidyl Inositol 3-Kinase (PI3K) inhibitor LY294002 and were abrogated with the …

Distribution Of Erm Proteins In The Stomach Mucosa Of Normal And Diabetic Rats, Asmaa Salem Al Sereidi

Theses

Diabetes mellitus (DM), or simply diabetes, refers to a group of metabolic disorders that include a variety of diseases that disrupt our body's metabolism. The long-term uncontrolled disease can lead to stomach complications such as gastroparesis, as well as disruption in several proteins, such as ERM (Ezrin, radixin, moesin) proteins. ERM proteins are three proteins that are structurally and functionally related. ERM proteins have molecular masses of 82, 80, and 75 kDa, respectively. Ezrin is highly expressed in the stomach, especially in parietal cells that secrete gastric acid. ERM proteins function as scaffolding proteins in lipid rafts and granule trafficking …

Addictive Social Media Use: Examination Of The Psychometric Properties Of The Arabic Bergen Social Media Addiction Scale And The Mediational Role Of Sense Of Control In The Relationship Between Depression And Social Media Addiction, Louis J. Fourie

Theses

The period of COVID-19 has proven to be a turbulent period where extreme psychological trends can be examined due to lockdown procedures, social isolation, and public fear. The use of technology such as social media has increased with research highlighting the harm of overuse. The purpose of the current study is to investigate the psychometric properties of an Arabic translated version of the Bergen Social Media Addiction Scale (BSMAS) to assess for addictive social media use. Secondly, the study further examines the association between depression, social media addiction, and an individual’s sense of control. Specifically, the potential mediational role of …

Phubbing And Fear Of Missing Out As Mediators Between Problematic Social Media Use And Life Satisfaction Among Young Adults, Najeera Peer Meera Levai

Theses

Recent studies have shown certain risk indicators for young adults' decreased life satisfaction as a result of excessive social media use. However, few studies have looked at possible impact of problematic social media on life satisfaction, and less information is known about the mediating factors that contribute to this association. The purpose of the current study was to determine whether problematic social media use predicts life satisfaction among young adults. It also explored whether phubbing behaviour and fear of missing out might both serve as mediators in this relationship. A sample of 351 young adults (18–25, M_age = 19.74 …

The Effect Of Experiential Avoidance And Committed Action On The Relationship Between Anxiety And Quality Of Life In Chronically Ill And Healthy Students, Rufaida Mohammed N Alkhanji

Theses

Chronic illness and anxiety are two factors that have been shown to negatively impact quality of life. In order to better understand the impact of chronic illness on quality of life, researchers have been interested in studying the effects of experiential avoidance and committed action. This thesis aims to examine the roles of experiential avoidance and committed action as potential mediators in the relationship between anxiety and quality of life. It also aims to compare the occurrence of the studied relationships in students with and without chronic illness. 547 participants from two Arab universities completed self-report measures assessing their levels …

Infertility Characterization, Factors Associated With Primary Infertility, And Seroprevalence Of Genital Infections: A Cross-Sectional Survey In Abu Dhabi, United Arab Emirates, Noor Motea Abdo

Dissertations

Worldwide, infertility affects 8%–10% of couples and it could be primary or secondary. In the United Arab Emirates (UAE), one in every six couples are facing difficulties in conceiving. However, there is a noticeable lack of epidemiological studies and empirical data characterizing populations seeking infertility treatment in the UAE. Therefore, to inform health policy planning, evidence-based data is required to understand the most common type of infertility and the burden of exposure to genital pathogens. To characterize fertility-treatment-seeking patients, investigate factors associated with primary infertility, and to estimate the seroprevalence of six pathogens known to be transmitted genitally and associated …

Impact Of Dietary Walnuts, A Nutraceutical Option, On Circulating Markers Of Metabolic Dysregulation In A Rodent Cachectic Tumor Model, Lauri O. Byerley, Hsiao Man Chang, Brittany Lorenzen, Jessie Guidry, W. Elaine Hardman

School of Medicine Faculty Publications

Background: Nutraceutical foods, like walnuts which are rich in immunonutrients, can have medicinal benefits. Dietary walnuts have been shown to slow or prevent tumor growth in mice genetically programmed to grow breast or prostate tumors. This study investigated whether walnuts could exert the same preventable effect in a transplantable carcinoma rat model. Methods: Eighteen rats were randomly fed a diet containing walnuts (10% of food by weight), and 36 were fed a diet without walnuts (control) for 21 days. On day 22, 18 control diet rats were switched to the walnut diet. All other animals remained on their same diet. …

Predictive Self-Organizing Neural Networks For In-Home Detection Of Mild Cognitive Impairment, Seng Khoon Teh, Iris Rawtaer, Ah-Hwee Tan

Research Collection School Of Computing and Information Systems

In-home sensing of daily living patterns from older adults coupled with machine learning is a promisingapproach to detect Mild Cognitive Impairment (MCI), a potentially reversible condition with early detectionand appropriate intervention. However, the number of subjects involved in such real-world studies istypically limited, posing the so-called small data problem to most predictive models which rely on a sizablenumber of labeled data. In this work, a predictive self-organizing neural network known as fuzzy AdaptiveResonance Associate Map (fuzzy ARAM) is proposed to detect MCI using in-home sensor data collected from aunique Singapore cross-sectional study. Specifically, mean and standard deviation of nine in-home …

Thank You To Our 2021-2022 Reviewers, Paul B. Freeman Od

Optometric Clinical Practice

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