Medicine and Health Sciences Commons^™

Investigating The Role Of The Hedgehog Pathway In Connection To Atrazine Endocrine Disruption, Anusha Kv Lakshmi Dharmavathi

The Journal of Purdue Undergraduate Research

No abstract provided.

Developmental Behavioral Alterations Following Lead (Pb) Exposure In The Zebrafish Model System, Jenny Chen

The Journal of Purdue Undergraduate Research

No abstract provided.

Microaggression Among Registered Nurses: An Exploratory Study, Saige Addison

The Journal of Purdue Undergraduate Research

No abstract provided.

Working Out The Kinks: Creating Solutions To Assist Health Care Workers To Take Vital Signs Through Effective Cable Management, Carl R. Russell Iii, Emily J. Linder, Maya A. Godbole

Purdue Journal of Service-Learning and International Engagement

EPICS (Engineering Projects in Community Service) is a service-learning design program run through Purdue University. It strives to teach students design skills through providing solutions for individuals, communities, and organizations in the surrounding area while mirroring engineering industry standards. BME (Bio-medical Engineering) is a team within EPICS that strives to serve community partners through biomedical applications. Members of a health care team often spend valuable time organizing cables associated with machines used to take patients’ vital signs. Due to time constraints and the fast-paced work environment, these cables may be mismanaged and damaged. The BME team is working on a …

Scai Shock: Does The Stage Help With Management Decisions?, Jacob C. Jentzer, David A. Baran

Journal of Shock and Hemodynamics

No abstract for an Editorial.

Future Perspectives In Acute Myocarditis Complicated By Cardiogenic Shock, Giovanni A. Tavecchia, Iside Cartella, Enrico Ammirati

Journal of Shock and Hemodynamics

Acute myocarditis is an inflammatory disease of the myocardium with a highly variable clinical course. Fulminant myocarditis (FM) represents the most threatening scenario with hemodynamic compromise and cardiogenic shock at presentation. Despite medical advances and the availability of promising mechanical circulatory support (MCS), FM is burdened by a dismal prognosis. Early referral to tertiary hospitals with MCS facilities and prompt diagnosis with endomyocardial biopsy are critical steps toward optimal management. Moreover, beyond supportive care, the prevention of irreversible myocardial damage with immunomodulating therapies must be proven in clinical trials. In this editorial, we briefly describe current evidence and future perspectives …

Surviving Sepsis Campaign: Strategies To Implement In Cardiogenic Shock Management, James Burke Md

Journal of Shock and Hemodynamics

The Surviving Sepsis Guidelines can serve as a structure to help educate and create a set of recommendations on how to care for patients through this complicated pathway of shock. Designing a cardiogenic shock bundle could reduce the variability of care and possibly improve survival. Also, a more standard protocol would allow a review of the outcomes and a system to change practice nationally when new data or technology becomes available. This could create a continuous quality improvement cycle. Creating a “Surviving Cardiogenic Shock” system could help provide awareness for recognition of cardiogenic shock and advanced management alternatives needed at …

Role Of Invasive Hemodynamics In Shock Management: Is A Pulmonary Artery Catheter Always Necessary?, Ajay J. Kirtane

Journal of Shock and Hemodynamics

The pulmonary artery (PA) catheter can be a useful tool in the management of patients with cardiogenic shock; however, there are challenges with the use of this catheter, and clinicians must balance the risks and benefits. In addition, clinicians must properly interpret data generated from a PA catheter in the context of other data to optimize a patient's hemodynamics.

Forged In The Fires Of Covid-19: The Evolution Of Systemic Therapy For Online Practice And Beyond, Lauren Skuba M.A., Mftc, Lindsay Edwards , Ph.D.

Counseling and Family Therapy Scholarship Review

There has been a swift uptake in the use of teletherapy since the start of the COVID-19 pandemic, which has corresponded with an increase in clinical scholarship focused on conducting systemic therapy in an online format. A majority of this scholarship offers ideas for adapting therapeutic tasks developed around in-person contact for a remote format. The current article moves beyond adapting and offers ideas for remote systemic therapy that are born from our experiences of evolving through teletherapy. We begin by noting some of the significant differences between in-person therapy and teletherapy before describing how these differences can influence client …

Bowen Informed Therapy Integrated With Gene Keys, Kristen Oliver M.A.

Counseling and Family Therapy Scholarship Review

The mental health professions require innovation in order to advance theory and practice. This article presents reimagined therapeutic work that joins the metaphysical element of Gene Keys with the largely accepted theoretical approach of Bowen Family Systems Theory. We propose the integration of metaphysics as a way to facilitate higher levels of differentiation – particularly in clients who have an expanded worldview inclusive of metaphysics. The reader is asked to stretch their beliefs and perspective as they read through this paper.

Mft Trainee Experiences Of Shame, Self-Criticism, And Self-Compassion In Their First Practicum, Mark Karris , Ph.D., Angela B. Kim Ph.D.

Counseling and Family Therapy Scholarship Review

The purpose of this transcendental phenomenological study was to explore the lived experiences of MFT trainee shame, self-criticism, and self-compassion. Additionally, this study also sought to understand how those experiences may affect a trainee’s clinical work as a first-time practicum student. Interviews were conducted with 15 trainees in a graduate program who were performing therapy at a practicum site. Utilizing Moustakas’ transcendental phenomenology, six essential themes emerged: (1) shame and self-criticism are interrelated and can affect therapeutic presence; (2) self-criticism can have a positive impact on clinical work; (3) trainees use metaphors to describe shame and self-criticism (4) self-compassion …

Using Stories With Families: A Scoping Review, Sam Hadji Cyrous Ph.D. (Candidate), Sofia Valadares Nishiyama Cordeiro, Ana Caroline De Caldas

Counseling and Family Therapy Scholarship Review

This article is the fruit of a systematic scoping review, according to PRISMA precepts. Its objective was to explore the use of stories and other symbolic genre on family therapy settings. Thus, it explains how the researchers made the selection of articles in phases or steps, in a total of six, having a final result of 11 articles, in a time-lapse of 28 years. By the one hand, it was observed a relationship between different techniques that are usually grouped separately and, by the other hand, the disparate way in which the same concepts are confused among researchers, where each …

Notes On Language In The Clinic In A Lacanian Key, Sean J. Carroll

Counseling and Family Therapy Scholarship Review

There is no shortage of therapeutic modalities and interventions at the therapist’s disposal. Psychotherapy, because it claims to treat the individual, is necessarily multifaceted and complex. The dimension of language which structures much of our experience should be considered as a starting point for a psychotherapeutic technique. French psychoanalyst Jacques Lacan developed a theory and technique of the talking cure beginning from this assumption: that language structures our experience. In the early 1950s he sought to recover a linguistic Freud: to re-center psychoanalytic psychotherapy on language itself. In this paper, I sketch the theoretical reasons for this turn in Lacan …

Graphic Novel, Maya Sanchez

Human Diseases Graphic Novels

No abstract provided.

The Immune System: Arthritis, Melanie Cuenca '23, Rylie Bozarth '23

Human Diseases Graphic Novels

No abstract provided.

The Skeletal System – Osteoporosis, Melanie Cuenca '23, Rylie Bozarth '23

Human Diseases Graphic Novels

No abstract provided.

Asthma / Pneunomia / Cystic Acne / Eczema, Gabi Pride '24, Clarissa Gonzalez '24

Human Diseases Graphic Novels

No abstract provided.

Asthma, Sophia Syed '23, Grace Daum '23, Shanan Riley '23, Liz Carlson '23

Human Diseases Graphic Novels

No abstract provided.

Australian General Practice Training Program: National Report On The 2022 National Registrar Survey, Rebecca Taylor, Leyna Clarke, Ali Radloff

Higher education research

The Australian General Practice Training National Registrar Survey (AGPT NRS) is an annual, national survey of GP registrars currently training in the AGPT program. It collects information via an online questionnaire about registrar satisfaction, experience and future career plans. It also collects information about registrars’ demographics and training contexts and other aspects of their training experience. This survey is part of the Department of Health and Aged Care’s (the Department) monitoring and quality improvement activities. From June 27 until August 12, 2022, the Australian Council for Educational Research (ACER) administered the AGPT NRS to registrars enrolled in active training on …

Carum Carvi Modulates Acetaminophen-Induced Hepatotoxicity: Effects On Tnf-Α, Nf-Κb, And Caspases, Tahir Maqbool Mir, Muneeb U. Rehman, Mohammad Khalid Ashfaq, Wajhul Qamar

Faculty and Student Publications

Carum carvi is a well-known herb traditionally used as a spice in Asian countries. Acetaminophen is a known marketed drug mainly used as an analgesic. It has been scientifically proven that consumption of acetaminophen (paracetamol) is associated with liver toxicity if taken in high doses without medical supervision. The present study evaluated the in vivo antioxidant and hepatoprotective efficacy of Carum carvi against acetaminophen-induced hepatotoxicity in Wistar rats. Our results demonstrate that Carum carvi, at doses (mg/kg) of 100 (D1) and 200 (D2), showed inhibitory properties for DNA-sugar damage, lipid peroxidation, DPPH scavenging, and increased reducing potential in a concentration-dependent …

Development Of A Gc/Q-Tof-Ms Method Coupled With Headspace Solid-Phase Microextraction To Evaluate The In Vitro Metabolism Of Β-Caryophyllene, Joseph Lee, Mei Wang, Goutam Mondal, Ikhlas A. Khan

Faculty and Student Publications

Sample preparation remains both a challenging and time-consuming process in the field of bioanalytical chemistry. Many traditional techniques often require multi-step processes, which can introduce additional errors to the analytical method. Given the complexity of many biological matrices, thorough analyte extraction presents a major challenge to researchers. In the present study, a headspace solid-phase microextraction (HS-SPME) coupled with a GC/Q-ToF-MS method, was developed to quantify in vitro metabolism of β-caryophyllene by both human liver microsome (HLM) and S9 liver fractions. Validation of the method was demonstrated both in terms of linearity (R2 = 0.9948) and sensitivity with a limit of …

Comparative Genomics Of Streptococcus Oralis Identifies Large Scale Homologous Recombination And A Genetic Variant Associated With Infection, Luke R. Joyce, Madison A. Youngblom, Harshini Cormaty, Evelyn Gartstein

Faculty and Student Publications

The viridans group streptococci (VGS) are a large consortium of commensal streptococci that colonize the human body. Many species within this group are opportunistic pathogens causing bacteremia and infective endocarditis (IE), yet little is known about why some strains cause invasive disease. Identification of virulence determinants is complicated by the difficulty of distinguishing between the closely related species of this group. Here, we analyzed genomic data from VGS that were isolated from blood cultures in patients with invasive infections and oral swabs of healthy volunteers and then determined the best-performing methods for species identification. Using whole-genome sequence data, we characterized …

Rosmarinic Acid Prevents Cisplatin-Induced Liver And Kidney Injury By Inhibiting Inflammatory Responses And Enhancing Total Antioxidant Capacity, Thereby Activating The Nrf2 Signaling Pathway, Yifei Xiang, Min Ji, Liqin Wu, Li Lv

Faculty and Student Publications

Drug-induced liver and kidney damage is an emergent clinical issue that should be addressed. Rosmarinic acid (RA) has obvious anti-inflammatory and antioxidant effects, so we evaluated the anti-inflammatory and antioxidant effects of RA pretreatment on serum and liver and kidney tissues of cisplatin (CP)-treated mice and explored the possible mechanisms. The results showed that RA pretreatment effectively downregulated the serum, liver, and kidney levels of ALT, AST, BUN, and CRE and the inflammatory factors IL-1β, IL-6, and TNF-α, and simultaneously enhanced the total antioxidant capacity of the liver and kidney. RA pretreatment significantly reduced the levels of MPO, MDA, and …

Nurse Residency Programmatic Changes For Improved Retention During The Covid-19 Pandemic, Brittany Patterson Rn

Nursing Research and Scholarship 2022

Nursing Scholarship Symposium Event Posters.

Synchronized Diaphragmatic Stimulation For Heart Failure With A Reduced Left Ventricular Ejection Fraction Using The Visone System: A First-In-Patient Study With Extended Population, Ana Jorbenadze Md, Lee R. Goldberg Md, Tamaz Shaburishvili Md, Michel Zuber Md, Michael Mirro Md, Facc, Fhrs, Faha, Marat Fudim Md,Mh

Parkview Heart Institute

Highlights

• Synchronized diaphragmatic stimulation (SDS) is a new extra-cardiac HFrEF therapy
• SDS impacts intrathoracic pressure and pericardial restraint•
• SDS exhibits a favorable safety profile over 1 year of chronic use
• Exercise tolerance and QOL improved with SDS over 1 year
• Early results will soon be validated in a randomized control trial

Abstract

Background

Nurse Residency Programmatic Changes For Improved Retention In The Covid-19 Pandemic, Brittany Patterson Rn, Julia Racicot Rn

Research and Education Celebration 2023 - Nursing Research Posters

No abstract provided.

Policy Forum: Examining The Relationship Between Vacant Health Director Positions & Public Health, Ben Barber

Virginia Journal of Public Health

No abstract provided.

Applying Lessons Learned: Nursing Facility Administrators’ Operational And Ethical Challenges During Covid-19, Mary Eleanor R. Wickersham

Journal of Health Ethics

Operational and ethical challenges for nursing homes across the United States during the COVID-19 pandemic were daunting, that experience perhaps only a forecast of future epidemics that nursing home administrators and operators may face. This article describes administrator-identified challenges and focuses on how nursing homes might learn from their experiences by increasing flexibility to meet evolving needs, improving quality assurance and disaster planning, using ethics policies and ethical decision-making processes to work through difficult decisions, and leading the way in creating new policies that will make nursing home care safer and more appropriate for patients with ever changing needs.

Theory Building As Integrated Reflection: Understanding Physician Reflection Through Human Communication Research, Medical Education, And Ethics, Andrea Vicini, Ashley P. Duggan, Allen F. Shaughnessy

Journal of Health Ethics

Grounded in a presupposition that a single explanatory framework cannot fully account for the expansive learning processes that occur during medical residency, the article examines developing physicians’ reflective writing from three disciplinary lenses. The goal is to understand how the multi-dimensional nature of medical residency translates into assembling educational experiences and constructing meaning that cannot be fully explained through a single discipline. An interdisciplinary research team across medical education, communication, and ethics qualitatively analyzed reflective entries (N=756) completed by family medicine residents (N=33) across an academic year. Results provide evidence for moving toward an integrated thematic explanation across disciplines. The …

Extracellular Vesicles, Stem Cells And Neurological Disorders, Dinesh Upadhya Dr.

Health collection

Extracellular vesicles, including exosomes and microvesicles, offer great opportunities for understanding biological mechanisms and diagnostic prospects for various disorders. Our laboratory explores the potential of extracellular vesicles from multiple sources for mechanistic studies and for therapeutic applications to various neurological disorders. The laboratory has a well-established facility for generating, isolating and characterizing extracellular vesicles and aims to bring these EVs to clinical applications.

The pathological alterations that manifest during early embryonic development due to inherited and acquired factors trigger various neurodevelopmental disorders, including epilepsy, neuronal migration disorders and neurocognitive dysfunctions. Our work also focuses on the potential use of stem …