Medicine and Health Sciences Commons^™

Assessment And Risk Stratification Of Ageing-Related Target Organ Damage And Adverse Health Outcomes In The General Population, Jesus D. Melgarejo

School of Medicine Publications

The objectives of this doctoral thesis are to address the contribution of blood pressure to the presence of subclinical target-organ damage and the development of adverse health complications that associate with a poor life course of aging. This thesis focuses on ambulatory blood pressure monitoring to provide the most accurate information about the blood pressure level and variability over a 24-hour period. Moreover, by investigating the role of novel markers, including imaging markers and biomarkers, this thesis also provides possible pathophysiological and biological mechanisms that might explain the association between vascular risk factors and adverse health complications. We envisage that …

Middle Cuneiform Stress Fracture In A Postal Worker: A Case Report, Stephanie N. Campbell, Jacob M. Jones, Raul Aviles, Loren K. Spencer, John J. Anderson

School of Podiatric Medicine Publications

This report is to supplement the limited nature of isolated cuneiform fractures. Cuneiform fractures are identified as “low risk stress fracture” but with delayed diagnosis may cause prolonged treatment due to continued foot pain. Delayed diagnosis may be due to low sensitivity on radiographic exam and/or low suspicion clinically due to the rare involvement of isolated cuneiform fractures.

Maternal Healthcare Utilization Among Pregnant Women Experiencing Intimate Partner Violence: A Rapid Systematic Review, Gabrielle Harb

Master of Public Health Capstone Presentations

Intimate Partner Violence (IPV) impacts millions of pregnant women every year, and IPV is associated with adverse maternal and infant health outcomes. Previous studies have suggested that women experiencing IPV during pregnancy are less likely to access maternal healthcare services. Still, no consensus has been found, particularly within understudied low-and middle-income countries. This rapid systematic review identifies and examines evidence related to maternal healthcare utilization among women experiencing IPV in studies from 2015 to the present. A literature search was conducted in PubMed and Scopus, and 1797 unique records were identified. After reviewing abstracts and full texts, 28 studies were …

Process Mapping: The "One Best Way" To Improve Public Health Interventions, Adam T. Thompson

Master of Public Health Capstone Presentations

Process mapping (PM) is a quality improvement (QI) systems-level intervention used to analyze workflows in a variety of industries. PM is a robust improvement strategy but there is poor evidence for its effectiveness within healthcare QI projects. Evidence also suggests that there is variation in the implementation of PM likely affecting the value derived from the practice. In 2021, Antonacci, et al., proposed an empirical framework to guide the implementation, reporting, and evaluating of PM within healthcare QI projects. Informed by the empirical framework for process mapping (EFPM), the aim of this capstone was to enhance the value derived from …

The Impact Of Doulas On Birth Outcomes: A Rapid Systematic Review, Heather Higgins

Master of Public Health Capstone Presentations

Although most pregnancies in the United States are uncomplicated, adverse birth outcomes are more common in the U.S. than any other developed country (CDC, n.d.). The use of doula care during labor and delivery has shown to be effective in reducing adverse birth outcomes. A rapid systematic review was conducted to consolidate information on the effectiveness doulas have on certain adverse birth outcomes. These adverse birth outcomes included, low-birth weight, preterm birth, caesarean sections, shorter laboring time, and epidural use. The review of the literature was conducted using PubMed and search terms. PRISMA guidelines were followed and out of the …

The Development Of A Mobile App-Focused Deduplication Strategy For The Apple Heart Study That Informs Recommendations For Future Digital Trials, Ariadna Garcia, Justin Lee, Vidhya Balasubramanian, Rebecca Gardner, Santosh E. Gummidipundi, Grace Hung, Todd Ferris, Lauren Cheung, Sumbul Desai, Christopher B. Granger, Mellanie True Hills, Peter Kowey, Divya Nag, John S. Rumsfeld, Andrea M. Russo, Jeffrey W. Stein, Nisha Talati, David Tsay, Kenneth W. Mahaffey, Marco V. Perez, Mintu P. Turakhia, Haley Hedlin, Manisha Desai

Department of Medicine Faculty Papers

An app-based clinical trial enrolment process can contribute to duplicated records, carrying data management implications. Our objective was to identify duplicated records in real time in the Apple Heart Study (AHS). We leveraged personal identifiable information (PII) to develop a dissimilarity score (DS) using the Damerau-Levenshtein distance. For computational efficiency, we focused on four types of records at the highest risk of duplication. We used the receiver operating curve (ROC) and resampling methods to derive and validate a decision rule to classify duplicated records. We identified 16,398 (4%) duplicated participants, resulting in 419,297 unique participants out of a total of …

A Single Amino Acid Substitution In Porcine Reproductive And Respiratory Syndrome Virus Glycoprotein 2 Significantly Impairs Its Infectivity In Macrophages, Jayeshbhai Chaudhari, Raquel Arruda Leme, Kassandra Durazo-Martinez, Sarah Vitosh-Sillman, Aspen M. Workman, Hiep Vu

Nebraska Center for Virology: Faculty Publications

Porcine reproductive and respiratory syndrome virus (PRRSV) has a restricted tropism for macrophages and CD163 is a key receptor for infection. In this study, the PRRSV strain NCV1 was passaged on MARC-145 cells for 95 passages, and two plaque-clones (C1 and C2) were randomly selected for further analysis. The C1 virus nearly lost the ability to infect porcine alveolar macrophages (PAMs), as well as porcine kidney cells expressing porcine CD163 (PK15-pCD163), while the C2 virus replicates well in these two cell types. Pretreatment of MARC-145 cells with an anti-CD163 antibody nearly blocked C1 virus infection, indicating that the virus still …

A Rapid Systemic Review Of The Significance Of Parental Awareness Of Children’S Oral Health On The Prevalence Of Dental Caries In Saudi Arabia, Nasser Albishi

Master of Public Health Capstone Presentations

Dental caries in children has been identified as a public health challenge in the Kingdom of Saudi Arabia (KSA). Among those factors associated with their presence is the role that parents play in their children’s oral hygiene practices and how much it affects their development. The knowledge and awareness levels of the parents when it comes to maintaining proper oral hygiene in their children are still limited in the KSA, and a well-rounded characterization of these levels is needed for the problem to be addressed. Hence, a rapid systematic review was conducted to synthesize the evidence from published articles and …

The Emotional Well-Being Of Menstruating Women In South Asia: A Rapid Systematic Review, Payal Patel

Master of Public Health Capstone Presentations

In South Asia, many girls and women experience period poverty which is defined to be a lack of access to or affordability of menstrual hygiene products, washing facilities, and disposal methods. There is also a lack of education and conversation that surrounds menstruation, leading to there being stigma and taboo. With an absence of Wash, Sanitation, and Hygiene (WASH) facilities, women and girls in South Asia are unable to change their pads safely and privately, have access to clean water, and successfully manage their hygiene and health. Apart from the lack of education and WASH facilities, there are also unfair …

The Food Environment: Examining The Proximity Of Crimes To Food Stores, Nina Diamond

Master of Public Health Capstone Presentations

Food insecurity is a persistent and widespread issue in the United States. Individuals who are food insecure are more likely to develop chronic diseases due to their dietary habits, which tend to consist of ultra-processed foods. For many individuals, these habits are not by choice, but are the result of a lack of access to healthy foods. Both geographical and financial access issues often lead to these unhealthy diet choices, which increase an individual’s risk of morbidity and mortality. While the issue of food insecurity is complex, it is not often observed in the context of violence. Many food insecure …

Fall Reduction Strategies For Older Community Dwelling Americans, Heather L. Roach

Master of Public Health Capstone Presentations

Each year millions of older adults fall, and one out of five falls result in an injury that requires medical attention. In 2015 medical costs associated with falls was over $50 billion. Falls and specifically fall related injury in the older American population is a public health burden. There are many modalities that are implemented to reduce falls including management of underlying medical conditions, exercise regimens, supplementation, medication modifications, and home modifications. This project worked to identify which modalities had the greatest impact on falls. The goal of the information obtained is to inform practitioners and public health professionals that …

Reducing Liver Cancer Risk Through Dietary Change: Positive Results From A Community-Based Educational Initiative In Three Racial/Ethnic Groups, Lin Zhu, Ellen Jaeson Kim, Evelyn González, Marilyn A. Fraser, Steven Zhu, Nathaly Rubio-Torio, Grace X. Ma, Ming-Chin Yeh, Yin Tan

Publications and Research

Dietary behaviors and alcohol consumption have been linked to liver disease and liver cancer. So far, most of the liver cancer awareness campaigns and behavioral interventions have focused on preventive behaviors such as screening and vaccination uptake, while few incorporated dietary aspects of liver cancer prevention. We implemented a community-based education initiative for liver cancer prevention among the African, Asian, and Hispanic populations within the Greater Philadelphia and metropolitan New York City areas. Data from the baseline and the 6-month follow-up surveys were used for the assessment of changes in dietary behaviors and alcohol consumption among participants. In total, we …

"Everything…Fell Apart Once Covid-19 Hit"-Leveraging The Covid-19 Response To Strengthen Public Health Activities Toward Ending The Hiv Epidemic: A Qualitative Study, Samantha A Devlin, Moctezuma Garcia, Kayo Fujimoto, Camden Hallmark, Marlene Mcneese, John Schneider, Moira C Mcnulty

Faculty, Staff and Student Publications

COVID-19 caused widespread disruption of activities for Ending the HIV Epidemic (EHE). In this study we assessed public health perspectives on leveraging the COVID-19 response to advance the goals of EHE. We conducted a qualitative study with 33 public health partners in the Midwestern and Southern United States from October 2020 to February 2022. Participants were asked how the strategies developed for COVID-19 could be applied to the HIV epidemic. Interviews were recorded, transcribed, and examined using rapid qualitative analysis. Four themes emerged: (1) Rebuilding teams and adapting culture for success in EHE activities; (2) Recognizing and modernizing the role …

De Novo Serine Biosynthesis From Glucose Predicts Sex-Specific Response To Antifolates In Non-Small Cell Lung Cancer Cell Lines, Jasmin Sponagel, Siddhartha Devarakonda, Joshua B Rubin, Jingqin Luo, Joseph E Ippolito

2020-Current year OA Pubs

Lung cancer is the leading cause of cancer-related death. Intriguingly, males with non-small cell lung cancer (NSCLC) have a higher mortality rate than females. Here, we investigated the role of serine metabolism as a predictive marker for sensitivity to the antifolate pemetrexed in male and female NSCLC cell lines. Using [

Genome-Transcriptome-Functional Connectivity-Cognition Link Differentiates Schizophrenia From Bipolar Disorder, Jiayu Chen, Zening Fu, Juan R Bustillo, Nora I Perrone-Bizzozero, Dongdong Lin, Jose Canive, Godfrey D Pearlson, Julia M Stephen, Andrew R Mayer, Steven G Potkin, Theo G M Van Erp, Peter Kochunov, L Elliot Hong, Bhim M Adhikari, Ole A Andreassen, Ingrid Agartz, Lars T Westlye, Jing Sui, Yuhui Du, Fabio Macciardi, Faith M Hanlon, Rex E Jung, Jessica A Turner, Jingyu Liu, Vince D Calhoun

Faculty, Staff and Student Publications

BACKGROUND AND HYPOTHESIS: Schizophrenia (SZ) and bipolar disorder (BD) share genetic risk factors, yet patients display differential levels of cognitive impairment. We hypothesized a genome-transcriptome-functional connectivity (frontoparietal)-cognition pathway linked to SZ-versus-BD differences, and conducted a multiscale study to delineate this pathway.

STUDY DESIGNS: Large genome-wide studies provided single nucleotide polymorphisms (SNPs) conferring more risk for SZ than BD, and we identified their regulated genes, namely SZ-biased SNPs and genes. We then (a) computed the polygenic risk score for SZ (PRSSZ) of SZ-biased SNPs and examined its associations with imaging-based frontoparietal functional connectivity (FC) and cognitive performances; (b) examined the spatial …

Fine-Tuned Local Coordination Environment Of Pt Single Atoms On Ceria Controls Catalytic Reactivity, Wei Tan, Shaohua Xie, Duy Le, Weijian Diao, Meiyu Wang, Ke-Bin Low, Dave Austin, Sampyo Hong, Fei Gao, Lin Dong, Lu Ma, Steven N Ehrlich, Talat S Rahman, Fudong Liu

Faculty, Staff and Student Publications

Constructing single atom catalysts with fine-tuned coordination environments can be a promising strategy to achieve satisfactory catalytic performance. Herein, via a simple calcination temperature-control strategy, CeO2 supported Pt single atom catalysts with precisely controlled coordination environments are successfully fabricated. The joint experimental and theoretical analysis reveals that the Pt single atoms on Pt1/CeO2 prepared at 550 °C (Pt/CeO2-550) are mainly located at the edge sites of CeO2 with a Pt-O coordination number of ca. 5, while those prepared at 800 °C (Pt/CeO2-800) are predominantly located at distorted Ce substitution sites on CeO2 terrace with a Pt-O coordination number of ca. …

Scale-Up Of A Rh-Catalyzed Asymmetric Sp3–Sp2 Suzuki–Miyaura-Type Reaction, Laura Cunningham, Mireia Sidera Portela, Stephen P Fletcher

Faculty, Staff and Student Publications

Csp²–Csp² Suzuki–Miyaura couplings (SMCs) are ubiquitous in the synthesis of small molecules, but analogous Csp²–Csp³ bond-forming SMCs are rare, especially asymmetric variants. Recently, we developed a series of Rh-catalyzed couplings between racemic sp³-hybridized allyl chlorides and heteroaryl boronic acids. Here, we demonstrate that these catalytic asymmetric reactions can be scaled-up to give over 100 g of a product. The reaction we chose to test couples a heteroaromatic boronic acid derivative and a racemic bicyclic electrophile to give a product with three contiguous stereogenic centers. The SMC product was obtained as a single …

Addressing Substance Use And Misuse In East Texas: Stakeholder-Driven Needs And Priorities, Yordanos M. Tiruneh, Kimberly S. Elliot, Linda Oyer, Emmanuel Elueze, Vanessa Casanova

School of Medicine Faculty Publications and Presentations

Background: This project sought to assess needs, perceived challenges, and priorities regarding substance use disorder (SUD) in East Texas and develop a community-driven research agenda to address those challenges. Methods: Data were gathered through nine focus-group discussions (FGDs) with stakeholders: people living with SUD, families, medical providers, counselors, representatives of community-based organizations, and law enforcement officers. We asked participants how substance use manifests in their communities, which challenges they confronted in coping with substance use and misuse, and in which order their needs should be prioritized. Findings were reported at community forums to confirm the list of challenges and prioritize …

Impact Of Solid State Roadway Lighting On Melatonin In Humans, Ronald B Gibbons, Rajaram Bhagavathula, Benjamin Warfield, George Brainard, John P Hanifin

Department of Neurology Faculty Papers

Introduction: In 2009, the World Health Organization identified vehicle crashes, both injury-related and fatal, as a public health hazard. Roadway lighting has long been used to reduce crashes and improve the safety of all road users. Ocular light exposure at night can suppress melatonin levels in humans. At sufficient light levels, all visible light wavelengths can elicit this response, but melatonin suppression is maximally sensitive to visible short wavelength light. With the conversion of roadway lighting to solid state sources that have a greater short wavelength spectrum than traditional sources, there is a potential negative health impact through suppressed melatonin …

Chronic Exposure To Carbon Black Ultrafine Particles Reprograms Macrophage Metabolism And Accelerates Lung Cancer, Cheng-Yen Chang, Ran You, Dominique Armstrong, Ashwini Bandi, Yi-Ting Cheng, Philip M Burkhardt, Luis Becerra-Dominguez, Matthew C Madison, Hui-Ying Tung, Zhimin Zeng, Yifan Wu, Lizhen Song, Patricia E Phillips, Paul Porter, John M Knight, Nagireddy Putluri, Xiaoyi Yuan, Daniela C Marcano, Emily A Mchugh, James M Tour, Andre Catic, Laure Maneix, Bryan M Burt, Hyun-Sung Lee, David B Corry, Farrah Kheradmand

Faculty, Staff and Student Publications

Chronic exposure to airborne carbon black ultrafine (nCB) particles generated from incomplete combustion of organic matter drives IL-17A-dependent emphysema. However, whether and how they alter the immune responses to lung cancer remains unknown. Here, we show that exposure to nCB particles increased PD-L1+ PD-L2+ CD206+ antigen-presenting cells (APCs), exhausted T cells, and Treg cells. Lung macrophages that harbored nCB particles showed selective mitochondrial structure damage and decreased oxidative respiration. Lung macrophages sustained the HIF1α axis that increased glycolysis and lactate production, culminating in an immunosuppressive microenvironment in multiple mouse models of non-small cell lung cancers. Adoptive transfer of lung APCs …

Influence Of Data Sampling Methods On The Representation Of Neural Spiking Activity In Vivo, Meike E Van Der Heijden, Amanda M Brown, Roy V Sillitoe

Duncan NRI Faculty and Staff Publications

No abstract provided.

Spatial Definition Of The Human Progesterone Receptor-B Transcriptional Complex, Xinzhe Yu, Ping Yi, Anil K Panigrahi, Lance Edward V Lumahan, John P Lydon, David M Lonard, Steven J Lutdke, Zhao Wang, Bert W O'Malley

Faculty, Staff and Students Publications

We report the quaternary structure of core transcriptional complex for the full-length human progesterone receptor-B (PR-B) homodimer with primary coactivator steroid receptor coactivator-2 (SRC-2) and the secondary coactivator p300/CREB-binding protein (CBP). The PR-B homodimer engages one SRC-2 mainly through its activation function 1 (AF1) in N-terminus. SRC-2 is positioned between PR-B and p300 leaving space for direct interaction between PR-B and p300 through PR-B's C-terminal AF2 and its unique AF3. Direct AF3/p300 interaction provides long-desired structural insights into the known functional differences between PR-B and the PR-A isoform lacking AF3. We reveal the contributions of each AF and demonstrate their …

Direct Reprogramming Of Cardiomyocytes Into Cardiac Purkinje-Like Cells, Nicole Prodan, Faheem Ershad, Arfaxad Reyes-Alcaraz, Luge Li, Brandon Mistretta, Lei Gonzalez, Zhoulyu Rao, Cunjiang Yu, Preethi H Gunaratne, Na Li, Robert J Schwartz, Bradley K Mcconnell

Faculty, Staff and Students Publications

Currently, there are no treatments that ameliorate cardiac cell death, the underlying basis of cardiovascular disease. An unexplored cell type in cardiac regeneration is cardiac Purkinje cells; specialized cells from the cardiac conduction system (CCS) responsible for propagating electrical signals. Purkinje cells have tremendous potential as a regenerative treatment because they may intrinsically integrate with the CCS of a recipient myocardium, resulting in more efficient electrical conduction in diseased hearts. This study is the first to demonstrate an effective protocol for the direct reprogramming of human cardiomyocytes into cardiac Purkinje-like cells using small molecules. The cells generated were genetically and …

Evaluation Of Cisplatin-Induced Pathology In The Larval Zebrafish Lateral Line, David S Lee, Angela Schrader, Emily Bell, Mark E Warchol, Lavinia Sheets

2020-Current year OA Pubs

Cisplatin is an effective anticancer agent, but also causes permanent hearing loss by damaging hair cells-the sensory receptors essential for hearing. There is an urgent clinical need to protect cochlear hair cells in patients undergoing cisplatin chemotherapy. The zebrafish lateral line organ contains hair cells and has been frequently used in studies to screen for otoprotective compounds. However, these studies have employed a wide range of cisplatin dosages and exposure times. We therefore performed a comprehensive evaluation of cisplatin ototoxicity in the zebrafish lateral line with the goal of producing a standardized, clinically relevant protocol for future studies. To define …

An Mtorc1 To Hri Signaling Axis Promotes Cytotoxicity Of Proteasome Inhibitors In Multiple Myeloma, Odai Darawshi, Barbara Muz, Et Al.

2020-Current year OA Pubs

Multiple myeloma (MM) causes approximately 20% of deaths from blood cancers. Notwithstanding significant therapeutic progress, such as with proteasome inhibitors (PIs), MM remains incurable due to the development of resistance. mTORC1 is a key metabolic regulator, which frequently becomes dysregulated in cancer. While mTORC1 inhibitors reduce MM viability and synergize with other therapies in vitro, clinically, mTORC1 inhibitors are not effective for MM. Here we show that the inactivation of mTORC1 is an intrinsic response of MM to PI treatment. Genetically enforced hyperactivation of mTORC1 in MM was sufficient to compromise tumorigenicity in mice. In vitro, mTORC1-hyperactivated MM cells gained …

Cu Anschutz Digital Collections Migration: From Dspace To Hyku, Raven Morrigan

Medical Institutional Repositories in Libraries (MIRL)

Strauss Library at the University of Colorado Anschutz Medical Campus was part of the regional group of repositories called Mountain Scholar using DSpace when the lead for Mountain Scholar, Colorado State University (CSU), announced that they could no longer afford to support the Mountain Scholar instance. All the libraries currently part of Mountain Scholar had to decide whether to migrate to ContentDM with CSU or strike out on their own. Strauss Library considered our options, and with University of Colorado Boulder using Samvera, decided to pursue migrating to Samvera. The library completed the migration to Hyku, an extension of Samvera, …

Moving Metadata And Medicine: Migrating A Nursing History Photograph Collection To Digital Commons, Maureen Cech

Medical Institutional Repositories in Libraries (MIRL)

The Center for Nursing History of Northeastern Pennsylvania (CNH) at Misericordia University documents the history of nursing and the many nursing schools in the Keystone State's Wyoming Valley. In 2015, the Center received a grant to digitize and host its photograph collection to establish a stable digital environment for this regionally significant collection. This presentation will share some challenges, successes, and lessons learned during the migration of over 500 digital objects from ArtStor Public Collections to the Library's institutional repository on Digital Commons.

Making Cancer History Online: The Openworks @ Md Anderson Legacy Page, Jose Javier Garza

Medical Institutional Repositories in Libraries (MIRL)

In 2021, the Research Medical Library of the University of Texas MD Anderson Cancer Center launched its new institutional repository titled OpenWorks @ MD Anderson. While touted as an online hub for scholarly communications and open-access education materials, it also serves as the digital archives of the Historical Resources Center (HRC). The HRC's mission is to collect, preserve, and promote archival collections that document MD Anderson's 80-year legacy of fighting cancer. OpenWorks provides an opportunity to merge the past with the present by hosting digital collections with current scholarship in a shared online ecosystem. Historical interviews about MD Anderson's past …

Cheese In The Maze: Navigating Administrative Processes For A Digital Collection Migration, Pamela Pierce, Tracy Thornton

Medical Institutional Repositories in Libraries (MIRL)

Oregon Health & Science University is a complex organization with labyrinthine administrative processes. "Cheese in the Maze" will describe the process of getting our digital collection items out of Samvera and into Tind. Specific attention will be given to the administrative labor that is often not visible or understood by a large variety of people at a university. Widely applicable lessons learned will be highlighted.

A Tale Of Two Migrations: A Medical Library Case Report, Lisa Palmer, Tess Grynoch, Sally Gore

Medical Institutional Repositories in Libraries (MIRL)

Launched in 2006, the eScholarship@UMassChan institutional repository has been an important digital platform at UMass Chan Medical School, hosting faculty research, student research, and unique original publications and scholarship. In June 2021, UMass Chan’s Lamar Soutter Library decided to migrate eScholarship@UMassChan from the bepress Digital Commons platform to two separate hosted platforms. Most content – over 25,000 items representing faculty and staff publications, theses and dissertations, conference proceedings, and departmental and project collections – moved to Open Repository, a DSpace repository platform hosted by Atmire. The Janeway publishing platform became the new home for the open access, peer-reviewed journals and …