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2022

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Articles 22861 - 22890 of 23775

Full-Text Articles in Medicine and Health Sciences

Completing Single-Cell Dna Methylome Profiles Via Transfer Learning Together With Kl-Divergence, Sanjeeva Dodlapati, Zongliang Jiang, Jiangwen Sun Jan 2022

Completing Single-Cell Dna Methylome Profiles Via Transfer Learning Together With Kl-Divergence, Sanjeeva Dodlapati, Zongliang Jiang, Jiangwen Sun

Computer Science Faculty Publications

The high level of sparsity in methylome profiles obtained using whole-genome bisulfite sequencing in the case of low biological material amount limits its value in the study of systems in which large samples are difficult to assemble, such as mammalian preimplantation embryonic development. The recently developed computational methods for addressing the sparsity by imputing missing have their limits when the required minimum data coverage or profiles of the same tissue in other modalities are not available. In this study, we explored the use of transfer learning together with Kullback-Leibler (KL) divergence to train predictive models for completing methylome profiles with …


Spaghetti Tracer: A Framework For Tracing Semiregular Filamentous Densities In 3d Tomograms, Salim Sazzed, Peter Scheible, Jing He, Willy Wriggers Jan 2022

Spaghetti Tracer: A Framework For Tracing Semiregular Filamentous Densities In 3d Tomograms, Salim Sazzed, Peter Scheible, Jing He, Willy Wriggers

Computer Science Faculty Publications

Within cells, cytoskeletal filaments are often arranged into loosely aligned bundles. These fibrous bundles are dense enough to exhibit a certain regularity and mean direction, however, their packing is not sufficient to impose a symmetry between—or specific shape on—individual filaments. This intermediate regularity is computationally difficult to handle because individual filaments have a certain directional freedom, however, the filament densities are not well segmented from each other (especially in the presence of noise, such as in cryo-electron tomography). In this paper, we develop a dynamic programming-based framework, Spaghetti Tracer, to characterizing the structural arrangement of filaments in the challenging 3D …


Loss Of Acta2 In Cardiac Fibroblasts Does Not Prevent The Myofibroblast Differentiation Or Affect The Cardiac Repair After Myocardial Infarction, Yuxia Li, Chaoyang Li, Qianglin Liu, Leshan Wang, Adam X. Bao, Jangwook P. Jung, Sanjeev Dodlapati, Jingwen Sun, Peidong Gao, Xujia Zhang, Joseph Francis, Jeffery D. Molkentin, Xing Fu Jan 2022

Loss Of Acta2 In Cardiac Fibroblasts Does Not Prevent The Myofibroblast Differentiation Or Affect The Cardiac Repair After Myocardial Infarction, Yuxia Li, Chaoyang Li, Qianglin Liu, Leshan Wang, Adam X. Bao, Jangwook P. Jung, Sanjeev Dodlapati, Jingwen Sun, Peidong Gao, Xujia Zhang, Joseph Francis, Jeffery D. Molkentin, Xing Fu

Computer Science Faculty Publications

In response to myocardial infarction (MI), quiescent cardiac fibroblasts differentiate into myofibroblasts mediating tissue repair. One of the most widely accepted markers of myofibroblast differentiation is the expression of Acta2 which encodes smooth muscle alpha-actin (SMαA) that is assembled into stress fibers. However, the requirement of Acta2/SMαA in the myofibroblast differentiation of cardiac fibroblasts and its role in post-MI cardiac repair remained unknown. To answer these questions, we generated a tamoxifen-inducible cardiac fibroblast-specific Acta2 knockout mouse line. Surprisingly, mice that lacked Acta2 in cardiac fibroblasts had a normal post-MI survival rate. Moreover, Acta2 deletion did …


Refinement Of Alphafold2 Models Against Experimental And Hybrid Cryo-Em Density Maps, Maytha Alshammari, Willy Wriggers, Jiangwen Sun, Jing He Jan 2022

Refinement Of Alphafold2 Models Against Experimental And Hybrid Cryo-Em Density Maps, Maytha Alshammari, Willy Wriggers, Jiangwen Sun, Jing He

Computer Science Faculty Publications

Recent breakthroughs in deep learning-based protein structure prediction show that it is possible to obtain highly accurate models for a wide range of difficult protein targets for which only the amino acid sequence is known. The availability of accurately predicted models from sequences can potentially revolutionise many modelling approaches in structural biology, including the interpretation of cryo-EM density maps. Although atomic structures can be readily solved from cryo-EM maps of better than 4 Å resolution, it is still challenging to determine accurate models from lower-resolution density maps. Here, we report on the benefits of models predicted by AlphaFold2 (the best-performing …


Toward A Real-Time Index Of Pupillary Activity As An Indicator Of Cognitive Load, Gavindya Jayawardena, Yasith Jayawardana, Sampath Jayarathna, Jonas Högström, Thomas Papa, Deepak Akkil, Andrew T. Duchowski, Vsevolod Peysakhovich, Izabela Krejtz, Nina Gehrer, Krzysztof Krejtz Jan 2022

Toward A Real-Time Index Of Pupillary Activity As An Indicator Of Cognitive Load, Gavindya Jayawardena, Yasith Jayawardana, Sampath Jayarathna, Jonas Högström, Thomas Papa, Deepak Akkil, Andrew T. Duchowski, Vsevolod Peysakhovich, Izabela Krejtz, Nina Gehrer, Krzysztof Krejtz

Computer Science Faculty Publications

The Low/High Index of Pupillary Activity (LHIPA), an eye-tracked measure of pupil diameter oscillation, is redesigned and implemented to function in real-time. The novel Real-time IPA (RIPA) is shown to discriminate cognitive load in re-streamed data from earlier experiments. Rationale for the RIPA is tied to the functioning of the human autonomic nervous system yielding a hybrid measure based on the ratio of Low/High frequencies of pupil oscillation. The paper's contribution is drawn from provision of documentation of the calculation of the RIPA. As with the LHIPA, it is possible for researchers to apply this metric to their own experiments …


The Impact Of High Flow Oxygen (Optiflow) And The Risk Of Aspiration In The Adult Population Within Critical Care Environments, Elaine Walsh, Amy Bernd, Tara Huggard, Patricia Schlegel Jan 2022

The Impact Of High Flow Oxygen (Optiflow) And The Risk Of Aspiration In The Adult Population Within Critical Care Environments, Elaine Walsh, Amy Bernd, Tara Huggard, Patricia Schlegel

Department of Medicine

No abstract provided.


A Rare Case Of Hypercalcemia Caused By Silicone Induced Foreign Body Granulomatous Reaction, Saloni Goyal Do, Kaitlin Buzard Do, Nabila Zamir Do, Philip Dunn Do Jan 2022

A Rare Case Of Hypercalcemia Caused By Silicone Induced Foreign Body Granulomatous Reaction, Saloni Goyal Do, Kaitlin Buzard Do, Nabila Zamir Do, Philip Dunn Do

Department of Medicine

No abstract provided.


Leukoencephalopathy Secondary To Heroin Inhalation: A Noteworthy Consideration, Patrick Davis Md, Sidney Okon, Francis Sean Wilson, David Finch, Beth Stepanczuk Md Jan 2022

Leukoencephalopathy Secondary To Heroin Inhalation: A Noteworthy Consideration, Patrick Davis Md, Sidney Okon, Francis Sean Wilson, David Finch, Beth Stepanczuk Md

Department of Medicine

No abstract provided.


Dissect The Case, Kaitlyn L. Buzard Do, Kaitlyn Dalsey Do, Lisa E.A. Dwyer-Joyce Md, Nicole Chiapetta Do, James Ross Md, Facp Jan 2022

Dissect The Case, Kaitlyn L. Buzard Do, Kaitlyn Dalsey Do, Lisa E.A. Dwyer-Joyce Md, Nicole Chiapetta Do, James Ross Md, Facp

Department of Medicine

No abstract provided.


Heart Health After Preeclampsia: A Model Of Care, Lekha Racharla Do, Kailyn Mann Do, Nidhi Mehta Md, Yasotha Rajeswaran Md, Amy M. Ahnert Md, Danielle E. Durie Md, Joanne Quiñones Md, Msce Jan 2022

Heart Health After Preeclampsia: A Model Of Care, Lekha Racharla Do, Kailyn Mann Do, Nidhi Mehta Md, Yasotha Rajeswaran Md, Amy M. Ahnert Md, Danielle E. Durie Md, Joanne Quiñones Md, Msce

Department of Medicine

No abstract provided.


Examining Associations Between Prone Position And Hospital Outcomes During The Covid-19 Pandemic, Sidney M. Stoddard Pt, Dpt, Daniel Sawyer Pt, Dpt, Michael Pechulis Dpt, Julie M. Skrzat Pt Dpt Phd Ccs, Mark Fuse, Amanda Fox, Elizabeth A. Wetzler, Mary Loose Pt, Ryan Vetter Ms-Otr/L, Kaitlyn Musco Md, Christopher Lenivy Do, Shae Duka Bs Jan 2022

Examining Associations Between Prone Position And Hospital Outcomes During The Covid-19 Pandemic, Sidney M. Stoddard Pt, Dpt, Daniel Sawyer Pt, Dpt, Michael Pechulis Dpt, Julie M. Skrzat Pt Dpt Phd Ccs, Mark Fuse, Amanda Fox, Elizabeth A. Wetzler, Mary Loose Pt, Ryan Vetter Ms-Otr/L, Kaitlyn Musco Md, Christopher Lenivy Do, Shae Duka Bs

Department of Medicine

No abstract provided.


How One Non-Profit Health Care Network Took A Comprehensive Driving Program From Concept To The Streets, Ryan Vetter Ms-Otr/L, Shelley Spence, Jeffrey Halbert Ms, Otr/L, Csrs Jan 2022

How One Non-Profit Health Care Network Took A Comprehensive Driving Program From Concept To The Streets, Ryan Vetter Ms-Otr/L, Shelley Spence, Jeffrey Halbert Ms, Otr/L, Csrs

Department of Medicine

No abstract provided.


Alternative Scheduling Framework To Decrease Waitlist And Improve Patient Satisfaction In Outpatient Pediatric Rehab, Shelley Spence, Kimberly Fritts Dpt Jan 2022

Alternative Scheduling Framework To Decrease Waitlist And Improve Patient Satisfaction In Outpatient Pediatric Rehab, Shelley Spence, Kimberly Fritts Dpt

Department of Medicine

No abstract provided.


Development Of An Occupational Therapy Pathway For Individuals Diagnosed With Covid-19 In The Acute Care Setting, Allison Hoffman, Danielle Accordino, Lauren Reightler Jan 2022

Development Of An Occupational Therapy Pathway For Individuals Diagnosed With Covid-19 In The Acute Care Setting, Allison Hoffman, Danielle Accordino, Lauren Reightler

Department of Medicine

No abstract provided.


Kounis Syndrome: A Rare Mediator Of Acute Coronary Syndrome, Amogh M. Joshi Do, Chun Siu, Zeel Patel Do, Mirza Ali, Amy Lam Do, Tarick Sheikh, Sagar Vadhar Do, Akhil Kher Md, Apurva Vyas Md Jan 2022

Kounis Syndrome: A Rare Mediator Of Acute Coronary Syndrome, Amogh M. Joshi Do, Chun Siu, Zeel Patel Do, Mirza Ali, Amy Lam Do, Tarick Sheikh, Sagar Vadhar Do, Akhil Kher Md, Apurva Vyas Md

Department of Medicine

No abstract provided.


Tracking The Implementation Of A Mental Health Smartphone Application At A Large Tertiary Care Health Network, Jennifer Yoon, Katherine B. Martin Md Jan 2022

Tracking The Implementation Of A Mental Health Smartphone Application At A Large Tertiary Care Health Network, Jennifer Yoon, Katherine B. Martin Md

USF-LVHN SELECT

No abstract provided.


Preoperative Immunonutrition And Carbohydrate Loading Associated With Improved Bowel Function After Radical Cystectomy, Sephalie Patel, Nathaniel Trona, Brandon Alford, Jose Laborde, Youngchul Kim, Roger Li, Brandon Manley, Scott Gilbert, Wade Sexton, Phillippe Spiess, Michael Poch Jan 2022

Preoperative Immunonutrition And Carbohydrate Loading Associated With Improved Bowel Function After Radical Cystectomy, Sephalie Patel, Nathaniel Trona, Brandon Alford, Jose Laborde, Youngchul Kim, Roger Li, Brandon Manley, Scott Gilbert, Wade Sexton, Phillippe Spiess, Michael Poch

USF-LVHN SELECT

No abstract provided.


Implementation Of A High-Sensitivity Troponin Assay For The Diagnosis Of Acute Coronary Syndrome At Lehigh Valley Hospital – Cedar Crest, Ben Thomas, Richard S. Mackenzie Md Jan 2022

Implementation Of A High-Sensitivity Troponin Assay For The Diagnosis Of Acute Coronary Syndrome At Lehigh Valley Hospital – Cedar Crest, Ben Thomas, Richard S. Mackenzie Md

USF-LVHN SELECT

No abstract provided.


Emergency Department Management Of Pediatric Chest Pain At Lehigh Valley Health Network, Chetna Thawani, Andrew Bressler, Susan K. Yaeger Md, Robert A. Palermo Do Jan 2022

Emergency Department Management Of Pediatric Chest Pain At Lehigh Valley Health Network, Chetna Thawani, Andrew Bressler, Susan K. Yaeger Md, Robert A. Palermo Do

USF-LVHN SELECT

No abstract provided.


Comparison And Outcome Analysis Of E.M. Resident Evidence-Based Medicine Questions, Phillip Sgobba Bs, Mbs, Estelle Cervantes Ba, Shreyas Kudrimoti Ba, Jacob Albers, Jeffrey B. Brown, Kashyap Kaul Do, William Spinosi Do, Ajay Varadhan, Joseph B. Zackary Md, Bryan G. Kane Md Jan 2022

Comparison And Outcome Analysis Of E.M. Resident Evidence-Based Medicine Questions, Phillip Sgobba Bs, Mbs, Estelle Cervantes Ba, Shreyas Kudrimoti Ba, Jacob Albers, Jeffrey B. Brown, Kashyap Kaul Do, William Spinosi Do, Ajay Varadhan, Joseph B. Zackary Md, Bryan G. Kane Md

USF-LVHN SELECT

No abstract provided.


Deployment Of A Best Practice Alert To Discourage Inpatient Orders For Repeat Echocardiograms, Drake Scott, Amy Slenker Md, Zhe Chen Md, Ronald S. Freudenberger Md, Kyle Shaak Bs Jan 2022

Deployment Of A Best Practice Alert To Discourage Inpatient Orders For Repeat Echocardiograms, Drake Scott, Amy Slenker Md, Zhe Chen Md, Ronald S. Freudenberger Md, Kyle Shaak Bs

USF-LVHN SELECT

No abstract provided.


Relationship Between Vaccination Status And Biopsychosocial Characteristics In Sheltered Adolescents, Ceyda H. Sablak Bs, Cecilia E. Zemanek Bs, Nina Liu, Brittany Gaudet Bs, Msph, Taylor Jarvill, Allison N. Kayne Bs, Jeffrey Downen, Hope Kincaid Mph, Cph, Amy B. Smith Phd, Robert D. Barraco Md, Mph, Hoonani M. Cuadrado, Marna R. Greenberg Do, Mph, Facep Jan 2022

Relationship Between Vaccination Status And Biopsychosocial Characteristics In Sheltered Adolescents, Ceyda H. Sablak Bs, Cecilia E. Zemanek Bs, Nina Liu, Brittany Gaudet Bs, Msph, Taylor Jarvill, Allison N. Kayne Bs, Jeffrey Downen, Hope Kincaid Mph, Cph, Amy B. Smith Phd, Robert D. Barraco Md, Mph, Hoonani M. Cuadrado, Marna R. Greenberg Do, Mph, Facep

USF-LVHN SELECT

No abstract provided.


Pilot Of The Lehigh Valley Hospital 17th Street Community Food Pharmacy Study: Improving Access To/Consumption Of Fresh Healthy Food To Improve Pediatric Health Outcomes – A Partnership With Full Cart, Nitisha Mehta, Kimberly C. Brown Md, Samantha A. Shaak Phd, Lisa Liddington Mba Jan 2022

Pilot Of The Lehigh Valley Hospital 17th Street Community Food Pharmacy Study: Improving Access To/Consumption Of Fresh Healthy Food To Improve Pediatric Health Outcomes – A Partnership With Full Cart, Nitisha Mehta, Kimberly C. Brown Md, Samantha A. Shaak Phd, Lisa Liddington Mba

USF-LVHN SELECT

No abstract provided.


Impact Of High-Sensitivity Troponin Assays On Ed Length Of Stay For Discharged Cardiac Patients, Muling Lin, Ben Thomas, Richard S. Mackenzie Md Jan 2022

Impact Of High-Sensitivity Troponin Assays On Ed Length Of Stay For Discharged Cardiac Patients, Muling Lin, Ben Thomas, Richard S. Mackenzie Md

USF-LVHN SELECT

No abstract provided.


Characterizing Inpatient Readmission Rates And Follow-Up Visits Within Lvhn, Mario Lavelanet, Matthew Mccambridge Md Jan 2022

Characterizing Inpatient Readmission Rates And Follow-Up Visits Within Lvhn, Mario Lavelanet, Matthew Mccambridge Md

USF-LVHN SELECT

Lavelanet, M & McCambridge, M. (2022). Characterizing inpatient readmission rates and follow-up visits within LVHN. Poster presented at Lehigh Valley Health Network, Allentown, PA.


Developing An Art Museum Workshop For Usf Select Medical Students, Ashley Kunnath, Amy B. Smith Phd Jan 2022

Developing An Art Museum Workshop For Usf Select Medical Students, Ashley Kunnath, Amy B. Smith Phd

USF-LVHN SELECT

No abstract provided.


Addressing Ongoing Racial, Gender, And Educational Biases Within Healthcare Developing Methods To Finally Close The Gap, Audrey Hughes, Grant M. Greenberg M.D., M.H.S.A., M.A., Judith Sabino Mph, Cdp, Elizabeth Leib Jan 2022

Addressing Ongoing Racial, Gender, And Educational Biases Within Healthcare Developing Methods To Finally Close The Gap, Audrey Hughes, Grant M. Greenberg M.D., M.H.S.A., M.A., Judith Sabino Mph, Cdp, Elizabeth Leib

USF-LVHN SELECT

No abstract provided.


Agents Of Exposure In Transgender Patient Cases Managed By A Toxicologist: An Analysis Of The Toxicology Investigator’S Consortium (Toxic) Registry, Olivia A. Hardy, Alexandra Amaducci Do, Judith Sabino Mph, Cdp, Beth Careyva M.D., Matthew D. Cook Do, Kenneth D. Katz Md, M G. Ryan, Ryan Surmaitis Do, Andrew L. Koons Do, Joseph B. Zackary Md, Gillian A. Beauchamp Md, Marna R. Greenberg Do, Mph, Facep Jan 2022

Agents Of Exposure In Transgender Patient Cases Managed By A Toxicologist: An Analysis Of The Toxicology Investigator’S Consortium (Toxic) Registry, Olivia A. Hardy, Alexandra Amaducci Do, Judith Sabino Mph, Cdp, Beth Careyva M.D., Matthew D. Cook Do, Kenneth D. Katz Md, M G. Ryan, Ryan Surmaitis Do, Andrew L. Koons Do, Joseph B. Zackary Md, Gillian A. Beauchamp Md, Marna R. Greenberg Do, Mph, Facep

USF-LVHN SELECT

No abstract provided.


Exploring The Short-Term Impact Of Provider Education On Lung Cancer Screening In Lvhn Primary Care Practices: A Pilot Quality Improvement Project, Kaylan Griffith, Grant M. Greenberg M.D., M.H.S.A., M.A., Melanie B. Johnson Mpa Jan 2022

Exploring The Short-Term Impact Of Provider Education On Lung Cancer Screening In Lvhn Primary Care Practices: A Pilot Quality Improvement Project, Kaylan Griffith, Grant M. Greenberg M.D., M.H.S.A., M.A., Melanie B. Johnson Mpa

USF-LVHN SELECT

No abstract provided.


Usage Of Scales To Guide Psychiatrist Clinical Judgment For Patients Receiving Electroconvulsive Therapy, Vivek Gorijala, Katherine B. Martin Md Jan 2022

Usage Of Scales To Guide Psychiatrist Clinical Judgment For Patients Receiving Electroconvulsive Therapy, Vivek Gorijala, Katherine B. Martin Md

USF-LVHN SELECT

No abstract provided.