Medicine and Health Sciences Commons^™

The James Business Operations Practicum, Noah R. Kuhn

Masters Theses/Capstone Projects

A Visual Representation of a 5 Month Practicum at The Ohio State University James Cancer Hospital and Solove Research Institute in the Business Operations Unit.

Effect Of Covid-19 Pandemic On Volunteerism And Fundraising Management Strategies In Nonprofits And Rebuilding Tactics Of Ronald Mcdonald House Charities Of Chicagoland And Northwest Indiana (Rmhc-Cni), Humza Wolf

Nonprofit and NGO Studies Student Projects

The financial sustainability of nonprofits depends highly on volunteerism and funding strategies which got impacted during Coronavirus 2019 (COVID-19) Pandemic. This capstone study explores to what extent nonprofits got affected and evaluates the efforts of Ronald McDonald House Charities of Chicagoland & Northwest Indiana (RMHC-CNI) to improve the provision of support for underprivileged families of critically ill children. The continual efforts to overcome financial hurdles escalated in pandemic. Mixed method research design was used to collect, analyze, and triangulate both quantitative and qualitative research methods in this single study to understand the research problem. Interpretive approach encompassed the complexities of …

Privacy-Aware Estimation Of Relatedness In Admixed Populations, Su Wang, Miran Kim, Wentao Li, Xiaoqian Jiang, Han Chen, Arif Harmanci

Faculty, Staff and Student Publications

BACKGROUND: Estimation of genetic relatedness, or kinship, is used occasionally for recreational purposes and in forensic applications. While numerous methods were developed to estimate kinship, they suffer from high computational requirements and often make an untenable assumption of homogeneous population ancestry of the samples. Moreover, genetic privacy is generally overlooked in the usage of kinship estimation methods. There can be ethical concerns about finding unknown familial relationships in third-party databases. Similar ethical concerns may arise while estimating and reporting sensitive population-level statistics such as inbreeding coefficients for the concerns around marginalization and stigmatization.

RESULTS: Here, we present SIGFRIED, which makes …

How Things Take Up Space: A Grounded Theory Of Presence And Lived Space, Aleš Oblak, Asena Boyadzhieva, Jaya Caporusso, Borut Škodlar, Jurij Bon

The Qualitative Report

In cognitive science, it is unclear what precisely presence (both in the sense of objecthood and immersion) refers to in lived experience. The present study addresses the research question of what the relationship between presence is and lived space. A hundred and seventeen phenomenological interviews were conducted with 14 participants. We sampled their experience in a transdiagnostic manner. That is, we observed how the experience of presence changes both in circumstances appraised as positive (e.g., sexual intimacy) and negative (e.g., psychopathology). Our grounded theory suggests that presence is a phenomenon that is comprised of all available sensory knowledge, however, it …

Cardiovascular/Stroke Risk Stratification In Diabetic Foot Infection Patients Using Deep Learning-Based Artificial Intelligence: An Investigative Study., Narendra N Khanna, Mahesh A Maindarkar, Vijay Viswanathan, Anudeep Puvvula, Sudip Paul, Mrinalini Bhagawati, Puneet Ahluwalia, Zoltan Ruzsa, Aditya Sharma, Raghu Kolluri, Padukone R Krishnan, Inder M Singh, John R Laird, Mostafa Fatemi, Azra Alizad, Surinder K Dhanjil, Luca Saba, Antonella Balestrieri, Gavino Faa, Kosmas I Paraskevas, Durga Prasanna Misra, Vikas Agarwal, Aman Sharma, Jagjit S Teji, Mustafa Al-Maini, Andrew Nicolaides, Vijay Rathore, Subbaram Naidu, Kiera Liblik, Amer M Johri, Monika Turk, David W Sobel, Martin Miner, Klaudija Viskovic, George Tsoulfas, Athanasios D Protogerou, Sophie Mavrogeni, George D Kitas, Mostafa M Fouda, Mannudeep K Kalra, Jasjit S Suri

Heart and Vascular Articles

A diabetic foot infection (DFI) is among the most serious, incurable, and costly to treat conditions. The presence of a DFI renders machine learning (ML) systems extremely nonlinear, posing difficulties in CVD/stroke risk stratification. In addition, there is a limited number of well-explained ML paradigms due to comorbidity, sample size limits, and weak scientific and clinical validation methodologies. Deep neural networks (DNN) are potent machines for learning that generalize nonlinear situations. The objective of this article is to propose a novel investigation of deep learning (DL) solutions for predicting CVD/stroke risk in DFI patients. The Preferred Reporting Items for Systematic …

New Insights Into Avian Infectious Bronchitis Virus In Colombia From Whole-Genome Analysis, Gloria Ramirez-Nieto, Daiana Mir, Diego Almansa-Villa, Geovanna Cordoba-Argotti, Magda Beltran-Leon, Nelida Rodriguez-Osorio, Jone Garai, Jovanny Zabaleta, Arlen P. Gomez

School of Medicine Faculty Publications

Infectious Bronchitis (IB) is a respiratory disease caused by a highly variable Gammacoronavirus, which generates a negative impact on poultry health worldwide. GI-11 and GI-16 lineages have been identified in South America based on Infectious Bronchitis virus (IBV) partial S1 sequences. However, full genome sequence information is limited. In this study we report, for the first time, the whole-genome sequence of IBV from Colombia. Seven IBV isolates obtained during 2012 and 2013 from farms with respiratory disease compatible with IB were selected and the complete genome sequence was obtained by NGS. According to S1 sequence phylogenetic analysis, six isolates belong …

Effect Of Covid-19 On The Implementation Of A Multifaceted Intervention To Improve Teamwork And Quality For Hospitalized Patients: A Qualitative Interview Study, Iva A Terwilliger, Milisa Manojlovich, Julie K Johnson, Mark V Williams, Kevin J O'Leary

2020-Current year OA Pubs

BACKGROUND: Healthcare organizations made major adjustments to deliver care during the COVID pandemic, yet little is known about how these adjustments shaped ongoing quality and safety improvement efforts. We aimed to understand how COVID affected four U.S. hospitals' prospective implementation efforts in an ongoing quality improvement initiative, the REdesigning SystEms to Improve Teamwork and Quality for Hospitalized Patients (RESET) project, which implemented complementary interventions to redesign systems of care for medical patients.

METHODS: We conducted individual semi-structured interviews with 40 healthcare professionals to determine how COVID influenced RESET implementation. We used conventional qualitative content analysis to inductively code transcripts and …

De-Identified Post-Conference Survey Results, Mirl 2022

Medical Institutional Repositories in Libraries (MIRL)

Includes the data file produced during the assessment phase of the MIRL 2022 symposium. Data was collected from a survey set to MIRL 2022 symposium participants.

Impact Of Nusinersen Treatment On Measures Of Exercise Intolerance In Spinal Muscular Atrophy, David Uher, Ashley M. Goodwin, Darryl C. De Vivo, Jacqueline Montes, Carol Ewing Garber Facsm

International Journal of Exercise Science: Conference Proceedings

Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disorder, marked by insufficient production of SMN protein, leading to motor neuron dysfunction. Although ubiquitously produced throughout the body, motor neurons and muscle cells are selectively impacted by decreased SMN, which has been linked to impaired oxidative phosphorylation causing altered metabolic function and exercise intolerance. Nusinersen, administered directly to the central nervous (CNS), is an approved therapy that increases SMN protein in an effort to restore motor neuron function. PURPOSE: To evaluate the impact of treatment on markers of exercise tolerance in children and adults treated with nusinersen is not known. …

Barriers To Adopting Lifestyle Behaviors Under The Prism Of Lifestyle Medicine, Janyll Barber, Zacharias Papadakis, Matthew Manierre, Ali Boolani, Andreas Stamatis

International Journal of Exercise Science: Conference Proceedings

According to the ACSM, lifestyle medicine (LM) is in the top 20 worldwide fitness trends for 2022. The LM pillars of a plant-based diet, physical activity, adequate sleep, stress management, social interactions, and avoidance of risky substances have been proposed as effective strategies for preventing and treating chronic conditions. However, implementing lifestyle behavioral changes to improve noncommunicable chronic disease outcomes has still been problematic. Individuals’ mental and physical status has been suggested as a key component in closing the gap between the intention to adopt a healthy lifestyle and actually adopting that behavior. PURPOSE: To examine the associations of …

Age-Related Changes In Skeletal Muscle Oxygen Utilization: A Review, Maxwell T. Aiken, Sabrina S. Salvatore, Kyle N. Zelenski, Ryan K. Perkins

International Journal of Exercise Science: Conference Proceedings

The cardiovascular and skeletal muscle systems are intrinsically interconnected, sharing the goal of delivering oxygen to metabolically active tissue. Deficiencies within those systems that affect oxygen delivery to working tissues are a hallmark of advancing age. Oxygen delivery and utilization are reflected as muscle oxygen saturation (SmO₂) and may be assessed using near-infrared resonance spectroscopy (NIRS). PURPOSE: This review is intended to provide an update on the current state of literature regarding age-related effects on SmO₂. Furthermore, we attempt to bridge the gap between SmO₂ and associated underlying mechanisms affected by aging. FINDINGS: SmO …

Mitochondrial Integrity Distinguishes Exercise-Induced Vs. Pathogenic Cardiac Hypertrophy, Nicole Lee Yang

International Journal of Exercise Science: Conference Proceedings

Cardiac hypertrophy is a consequence of exercise training, as well as certain cardiomyopathies. However, the key genetic drivers of cardiomyocellular remodeling in a healthy vs diseased heart are inadequately understood. PURPOSE: Determine the genetic architecture of exercise training-induced cardiomyocellular remodeling and hypertrophy. METHODS: The exercise hybrid mouse diversity panel (ExcHMDP) is comprised of 100 strains of Exc trained (TRN) and sedentary (SED) animals (n=4-8/strain per group). After 30d of exercise, running wheels were locked, and 24-hours post-exercise, 6h-fasted animals were euthanized and tissues harvested (~20 tissues/mouse). To interrogate pathogenic cardiac hypertrophy, isoproterenol (ISO, 30mg/kg/day for 21d) was administered to …

Preliminary Findings From A Pediatric Physical Activity Program For Children With Cancer, Paulette M. Yamada, Erin O. Bantum, Erin E. Centeio, Kelley Hutchins, Laura Bonilla, Carie Sumida, Jayna Lee, Sabrina Cao, Grace Lopez

International Journal of Exercise Science: Conference Proceedings

It is critical for pediatric patients diagnosed with cancer to engage in physical activity (PA) as it is associated with positive psychosocial outcomes and may improve physical function. However, physical activity opportunities for pediatric cancer patients are limited. PURPOSE: To test the feasibility and adherence of pediatric cancer patients to a virtual PA program. METHODS: Pediatric patients undergoing cancer treatment were referred to the Pediatric Physical Activity program (PePA) by the Children’s Hospital’s oncology team using rolling recruitment. The target sample size was 20-25 patients. Patients enrolled in an online 12-week PA intervention with similar-aged peers (2x/week, 60 …

Evaluating Research Survey Websites In Kinesiology: A Case Study Using An Accessibility Rating Form, Yi Sheng Wu, Jafra D. Thomas, Regina F. Hockert, Jasmine C. Wong, Samantha M. Ross

International Journal of Exercise Science: Conference Proceedings

Advancing equity in the research and educational practice of kinesiology requires intentional efforts to ensure access divides do not widen nor persist (Ross et al., in press, JOPERD). PURPOSE: Given knowledge of suitability assessment of materials (SAM) principles supports the equitable design of lay print and online material, we evaluated the extent they would also support developing a research survey website consistent with accessibility guidelines for digital technology. METHODS: The study website was adapted from the Canvas learning management system. A cross-sectional formative assessment was performed. Using their knowledge of SAM principles (eg, clear layout, text ≤ 8 …

Determining Validity And Reliability Of Caloric Expenditure Recorded By Wearable Technology While Walking And Running, Bianca C. Weyers, Dustin W. Davis, Nicole R. Vargas, Jorge Perdomo Rodriguez, Elias M. Malek, Katherine V. Carlos, Bryson Carrier, James W. Navalta

International Journal of Exercise Science: Conference Proceedings

With growing interest in tracking exercise progress, wearable technology is increasingly popular. While heart rate and step count are typically accurate for consumer-available devices, research from our laboratory indicates that caloric expenditure is not. PURPOSE: The current investigation aimed to evaluate the validity and reliability of caloric expenditure in multiple wearable devices during a self-paced walk and run. METHODS: Ten participants were tested (5F, 5M, age = 26.9± 9.43 years, body mass = 72.64± 7.73 kg, height = 168.66± 9.37 cm). Participants were asked to wear 5 devices: 2 Garmin Instinct watches (one on each wrist), 2 Polar Vantage M2 …

The Relationship Between Chronic Low Back Pain And Functional Movement, Lindsey Taylor Wensel, Spencer Baker

International Journal of Exercise Science: Conference Proceedings

ABSTRACT

Movements of the spine are different in those who have chronic low back pain (CLBP) compared to those who do not. By using inertial measurement units (IMUs), we assessed the angular acceleration of L5 and the sacrum in both healthy and CLBP individuals. PURPOSE: To determine if there is a difference in the movement patterns of L5 and the sacrum during spinal flexion in those with CLBP compared to those without. METHODS: Movement acceleration patterns were evaluated in 10 individuals between the ages of 35-65 years of age. 5 of the individuals reported having CLBP so they …

Aerobic Fitness Levels Relate To Cognitive Function In People With Parkinson’S Disease As Assessed By The 6 Minute Walk Test, John Wallace, Kaylie Zapanta, E Todd Schroeder, Beth Fisher

International Journal of Exercise Science: Conference Proceedings

While individuals with Parkinson’s disease (PD) present with impaired motor control, 26% demonstrate cognitive impairment independent of dementia¹. In fact, cognitive dysfunction often predates motor impairments and can diminish quality of life² as well as life expectancy³. Fortunately, aerobic exercise has been shown to improve cognition in older adults⁴ as well as PD patients^5-7. However, only a limited number of studies have determined a clear relationship between aerobic fitness levels and cognition in people with PD. Determining whether cognitive status and aerobic fitness levels are associated in people with PD would provide …

The Relationship Between Catecholamines And Lactate Concentration In Response To Exercise In Adolescents With Obesity, Vincent Vuong, Daniela Rubin

International Journal of Exercise Science: Conference Proceedings

Epinephrine is a catabolic hormone that increases metabolism through glycolysis and glycogenolysis. During exercise, accelerated glycogen and glucose breakdown is associated with increased lactate production. Previous studies show obesity (OB) decreases the epinephrine response during exercise potentially affecting glucose metabolism and lactate production. PURPOSE: To compare the epinephrine and lactate responses in adolescents with OB and adolescents with normal weight (NW) and to determine if changes in epinephrine and lactate concentrations are associated. METHODS: 12 adolescents with OB (9.2 ± 1.2 y, 39.9 ± 6.8% body fat) and 12 adolescents with NW (17.5 ± 4.6% body fat) completed …

Joint Angle Calculations Using Motion Capture And Deep Learning Pose Estimation While Running, Luke Vankeersbilck, Isaac Hedengren, Mcgyver Clark, Iain Hunter

International Journal of Exercise Science: Conference Proceedings

Marker based motion capture is currently the most accurate method of measuring human kinematics; however, it is expensive and is often limited to lab environments making it unsuitable for many applications. Two-dimensional methods are available through open source code, but it is unclear which of these methods provides the greatest accuracy. PURPOSE: The purpose of this study is to quantify the accuracy of pose estimation from a monocular electro-optical sensor with deep learning to infer segment end points and pose estimation utilizing two open-source code approaches. METHODS: One subject ran at 6.5 m/s for 15 s while being …

The Role Of Body Fat Percentage And Vo2max In Predicting Arterial Stiffness In Female College Students, Sara Thomasson, Grant Calhoun, Natalie Pham, Kennedy Kerbs, Sofia Harman, Payton Price, Annika Grams, Ruth Larson, Isaiah Mews, Zachary Zeigler, Anthony Acevedo

International Journal of Exercise Science: Conference Proceedings

Within the college population, high blood pressure (BP), as well as obesity and sedentary lifestyles, are seen. Bodyfat influences these outcomes. Much of the literature ignores the possible effects that fitness may have on these outcomes, specifically in females. Purpose: The intent of this study was to determine if VO_MAX can predict arterial stiffness after adjusting for body fat% in college females. Methods: Healthy young females were recruited from Grand Canyon University. Subjects came to the lab for a single visit for the following assessments: height, weight, waist circumference, hip circumference, aortic BP, augmentation pressure (AP), augmentation index adjusted …

Different Resistance Training Protocols During The Crunch Exercise Affect Muscle Thickness, Echo-Intensity, Load Lifted, And Perception Of Effort In Recreationally-Trained Participants., Keanna J. Sullivan, Paulo H. Marchetti

International Journal of Exercise Science: Conference Proceedings

The correct choice of the acute variables is another important component of a resistance training (RT) session. The combination of intensity and volume is fundamental to determine the dose-response in a RT session and can induce specific metabolic and mechanical stress in the muscle. PURPOSE: The primary purpose of this study was to evaluate acute dose-response of different volume x intensity RT protocols with equated total volume (40 repetitions) during the crunch exercise on muscle thickness, echo-intensity, load lifted, and rating of perceived exertion in recreationally-trained participants. METHODS: Fifteen resistance-trained participants (23±3years, 76.4±6.5kg, 173.3±6.5cm) performed the abdominal crunch exercise …

Shorter Versus Longer Bouts Of Rowing-Based Interval Exercise Attenuate The Physiological And Perceptual Response, Robert Sturdy, Austin Teske, Harrison Thomas, Pinelopi Stavrinou, Gregory C. Bogdanis, Todd Astorino Ph.D

International Journal of Exercise Science: Conference Proceedings

High intensity interval exercise (HIIE) requires repeated bouts of near-maximal to maximal efforts (intensities > 85 %HRmax) interspersed with a brief recovery. Data show superior increases in maximal oxygen uptake (VO 2max) in response to chronic HIIE compared to moderate intensity continuous exercise (MICE) in healthy adults as well as clinical populations (Milanovic et al. 2015; Weston et al., 2014). PURPOSE: This study compared physiological and perceptual variables between short and long durations of rowing-based high intensity interval exercise (HIIE). METHODS: Fourteen active adults (age = 26.4 ± 7.2 yr) performed incremental rowing exercise to fatigue to measure maximal …

Acute Effect Of Sauna On Blood Composition, Kate Strong, Olivia Leach, Jayson Gifford

International Journal of Exercise Science: Conference Proceedings

Sauna therapy has previously shown to benefit cardiovascular health. Nevertheless, the impact of sauna therapy on blood properties has not been described thus far. PURPOSE: The purpose of this study was to investigate the impact of a bout of sauna therapy on hemoglobin, hematocrit, and plasma volume. METHODS: Six healthy young adults (ages18-36; n=5 male, n=1 female) underwent a total of 40 min of sauna exposure in two 20 min increments. A baseline blood draw was performed pre-sauna. Participants underwent sauna exposure, and blood draws were performed directly post 40 mins of sauna, as well as after a 90-minute recovery …

Aging Male Runners Show Achilles Tendon Thinning Following A 10k Run While Females Do Not - Pilot Analysis, Annie Smedley, Joshua Sponbeck, Benjamin Smedley, Aaron W. Johnson

International Journal of Exercise Science: Conference Proceedings

The Achilles tendon experiences large amounts of force while running, which leads to Achilles tendon adaptation. One known Achilles tendon adaptation to running is Achilles tendon thinning. The Achilles tendon thinning response has not been examined at multiple locations of the Achilles tendon and has not been studied in an aging (>50 y) population. PURPOSE: We examined the effect of a 10k run on Achilles tendon cross sectional area in three locations of the Achilles tendon in runners aged 50 years and older. METHODS: Seven runners - three male (age = 73.6 y ±8.2, height = 174.4 …

A Career In Healthcare For Students In A Graduate Level Clinical Exercise Physiology Program, Julianne Skeen, Donna Cataldo, Holly Bright, Macy Wright, Zeyu Song, Robert Scales

International Journal of Exercise Science: Conference Proceedings

Physician referrals to physical therapy are common in mainstream healthcare practice. Clinical Exercise Physiologists (CEPs) are mostly limited to employment as a practitioner in supervised cardiac rehabilitation (CR) or cardiology-based diagnostics and stress testing. PURPOSE: This investigation was conducted to identify employment trends in healthcare for a cohort of CEPs prior to or within 1-year after graduation from an accredited CEP Program (2017-2022). METHODS: A 5-year retrospective review of university and internship site historical records was conducted to determine the career path of the CEPs. This investigation included a sample of 10 students (50% female) that successfully completed a cardiology-based …

Heavy Backpack Load Carriage Affects The Median Nerve, Deanna Schmidt, Jennifer Hein, Katherine Saul

International Journal of Exercise Science: Conference Proceedings

First responder and military personal often carry heavy backpacks of over 30% body weight when loaded with equipment. Use of the hands may be impaired by the compression of backpack straps on the nerves of the upper limb. PURPOSE: The aim of the study is to characterize the effects of walking with backpack load on upper limb function by examining changes in nerve conduction resulting from compression of the brachial plexus by backpack straps. We hypothesized that nerve conduction would be decreased in amplitude of the action potential and timing would be delayed after walking while carrying a 30% …

Make Reading Fun: Implications Of Virtual Reality On Standing Balance And Control, Makena Savola, Belle Ponce De Leon, Amanda Duben, Wendy T. Pham, Joshua Vicente, Jacob Hinkel-Lipsker

International Journal of Exercise Science: Conference Proceedings

The recent rapid expansion of virtual reality (VR) technology is driving a widespread number of new applications, including providing immersive environments for users to learn and read through commercially-available applications. However, recent research has shown that VR causes symptoms of dizziness and motion sickness, which could disrupt users gait and balance. Thus, it is important to understand how to best mitigate these effects before VR use becomes more widespread across the lay public. PURPOSE: The purpose of this study was to determine the acute effect of VR use on gait and balance control following use, and whether aspects of virtual …

Resisting Arrest: Analysis Of Different Prone Body Positions On Time To Stand And Engage, Krissy Sanchez, J. Jay Dawes, Mark Stephenson, Robin (Rob) Marc Orr, Robert G. Lockie

International Journal of Exercise Science: Conference Proceedings

An isolated police officer executing an arrest can be placed in a dangerous situation should the detainee become non-compliant. Further research is needed to ascertain the position that a detainee can be placed in that takes the longest time for them to rise from the ground, as this can influence the officer’s reaction time to a life-threatening situation. PURPOSE: Determine differences between participants' time from four prone positions to a standing athletic position which would then prepare the participant to engage or run from the officer, similar to what could be seen during an interaction between police and detainees. METHODS: …

Continuous Leg Cycling Ergometry Prescribed At Identical Relative Power Output Elicits Different Physiological Responses Versus Arm Cycle Ergometry, Tanner M. Robson, David W. Mcmillan, Todd A. Astorino Facsm

International Journal of Exercise Science: Conference Proceedings

PURPOSE: The aim of this study was to compare physiological and perceptual responses to progressive moderate intensity continuous exercise (MICE) between leg (LCE) and arm cycle ergometry (ACE). METHODS: Seventeen active men and women (age and percent body fat = 26 ± 7 yr and 18 ± 3 %) initially performed graded exercise on each modality to assess maximal oxygen uptake (VO2max) and peak power output (PPO). Using a randomized crossover design, they subsequently performed 45 min of MICE consisting of three 15 min bouts at 20, 40, and 60 % PPO on each modality. Gas exchange data (VO2, VCO2, …

Does Experimental Anterior Knee Pain Alter Effects Of Running On Femoral Articular Cartilage Thickness And Volume? A Pilot Study, Lauren N. Richardson, Andrew Pope, Sunku Kwon, Matthew K. Seeley

International Journal of Exercise Science: Conference Proceedings

Anterior knee pain is a common problem for runners that often alters running biomechanics. It is unclear how/if changes in running biomechanics due to anterior knee pain affect knee articular cartilage health. PURPOSE: To determine if experimental anterior knee pain during running acutely alters deformation in femoral articular cartilage due to running. METHODS: 10 runners completed three sessions that each in- volved a 60-min treadmill run: a control, sham, and pain session. Experimental anterior knee pain was in- duced during the pain session via a continuous infusion of hypertonic saline into the infrapatellar fat pad. The sham and control sessions …