Open Access. Powered by Scholars. Published by Universities.®

Medicine and Health Sciences Commons™

Open Access. Powered by Scholars. Published by Universities.®

2022

Discipline
Institution
Keyword
Publication
Publication Type
File Type

Articles 21571 - 21600 of 23775

Full-Text Articles in Medicine and Health Sciences

Can Delaying An Execution Due To Covid-19 Amount To Unconstitutional Discrimination?, Benjamin Joshua Ong Jan 2022

Can Delaying An Execution Due To Covid-19 Amount To Unconstitutional Discrimination?, Benjamin Joshua Ong

Research Collection Yong Pung How School Of Law

This note discusses the case of Syed Suhail bin Syed Zin v Attorney-General [2021] 1 SLR 809 (CA); [2021] 4 SLR 698 (HC) and its implications for equality law in Singapore.


Diagnostic Accuracy Of Computed Tomography In Adults With Suspected Acute Appendicitis At The Emergency Department In A Private Tertiary Hospital In Tanzania, Nyamuryekun'ge Miten, Miten Wr Patel, Ahmed Jusabani, Ali Akbar Zehri, Athar Ali Jan 2022

Diagnostic Accuracy Of Computed Tomography In Adults With Suspected Acute Appendicitis At The Emergency Department In A Private Tertiary Hospital In Tanzania, Nyamuryekun'ge Miten, Miten Wr Patel, Ahmed Jusabani, Ali Akbar Zehri, Athar Ali

General Surgery, East Africa

Introduction: The increasing incidence of acute appendicitis in sub-Saharan Africa emphasizes the need for accurate and reliable diagnostic tools. However, the variability in the diagnostic performance of computed tomography for suspected acute appendicitis coupled with comparatively higher negative appendectomy rates in this setting highlight a possible concern regarding the diagnostic accuracy. This study evaluated the diagnostic accuracy of a computed tomography scan for suspected acute appendicitis at the emergency department in Tanzania.

Methods: A retrospective diagnostic accuracy study was conducted from July to October 2020. All patients above 14 years of age who presented at the emergency department with …


Evaluation Of Venous Thromboembolism (Vte) Risk Assessment And Thrombo-Prophylaxis Practices In Hospitalized Medical And Surgical Patients At Aga Khan Hospital Dar Es Salaam: Single-Centre Retrospective Study, Allyzain Ismail, Nikhil Jadawji, Philip Adebayo, Ahmed Jusabani, Kamran Hamid, Ali Akbar Zehri, Willy Kiviri, Authar Ali Jan 2022

Evaluation Of Venous Thromboembolism (Vte) Risk Assessment And Thrombo-Prophylaxis Practices In Hospitalized Medical And Surgical Patients At Aga Khan Hospital Dar Es Salaam: Single-Centre Retrospective Study, Allyzain Ismail, Nikhil Jadawji, Philip Adebayo, Ahmed Jusabani, Kamran Hamid, Ali Akbar Zehri, Willy Kiviri, Authar Ali

General Surgery, East Africa

Introduction: venous thromboembolism is a complication among admitted medical and surgical patients. International guidelines recommend patients are assessed upon admission and appropriate thromboprophylaxis should be initiated. However, studies have shown that thromboprophylaxis for patients at risk of venous thromboembolism is underutilized.

Methods: this was a retrospective study conducted on hospitalized medical and surgical patients at Aga Khan Hospital Dar es salaam from January to June 2019. Patient’s medical records were reviewed and data was collected for analysis of venous thromboembolism assessment and compliance with Caprini risk assessment model. The data was entered into statistical package for the social …


Doctoral Physical Therapy Students' Increased Confidence Following Exploration Of Active Video Gaming Systems In A Problem-Based Learning Curriculum In The United States: A Pre-And Post-Intervention Study, Michelle E. Wormley, Wendy Romney, Diana Veneri, Andrea Oberlander Jan 2022

Doctoral Physical Therapy Students' Increased Confidence Following Exploration Of Active Video Gaming Systems In A Problem-Based Learning Curriculum In The United States: A Pre-And Post-Intervention Study, Michelle E. Wormley, Wendy Romney, Diana Veneri, Andrea Oberlander

Physical Therapy Faculty Publications

Purpose: Active video gaming (AVG) is used in physical therapy (PT) to treat individuals with a variety of diagnoses across the lifespan. The literature supports improvements in balance, cardiovascular endurance, and motor control; however, evidence is lacking regarding the implementation of AVG in PT education. This study investigated doctoral physical therapy (DPT) students' confidence following active exploration of AVG systems as a PT intervention in the United States.

Methods: This pretest-posttest study included 60 DPT students in 2017 (Cohort 1) and 55 students in 2018 (Cohort 2) enrolled in a problem-based learning curriculum. AVG systems were embedded into patient cases …


Physical Activity Interventions In Children With Juvenile Idiopathic Arthritis: A Systematic Review Of Randomized Controlled Trials, Maura D. Iversen, Marie Andre, Johan Von Heideken Jan 2022

Physical Activity Interventions In Children With Juvenile Idiopathic Arthritis: A Systematic Review Of Randomized Controlled Trials, Maura D. Iversen, Marie Andre, Johan Von Heideken

Physical Therapy Faculty Publications

Introduction: Children with juvenile arthritis (JA) experience pain, stiffness, fatigue, and decreased motion leading to difficulties with daily activities and low physical activity (PA). PA is critical to improve health and function and mitigate JA-associated symptoms. This study evaluated the evidence for PA interventions in children with JA.

Materials and methods: A systematic review of randomized controlled trials (RCTs) of PA interventions in children with JA was conducted. Ovid (Medline), Cochrane Library, EMBASE, and CINAHL databases were searched for papers published in English between 1/1/1946 and 9/1/2021. Studies which concurrently assessed medical interventions were excluded. Participant and intervention characteristics and …


Liver Cystic Disease, Alfarooq Alshaikhli, Alsadiq Al-Hillan Jan 2022

Liver Cystic Disease, Alfarooq Alshaikhli, Alsadiq Al-Hillan

School of Medicine Publications

Hepatic cysts (HCs) have been a common reason for consultation by gastroenterologists and hepatologists. HCs are defined as small abnormal fluid-filled lesions that develop within the liver tissue and usually arise from within hepatocytes, biliary cell epithelium, mesenchymal tissue, or metastases from extrahepatic organs. Hepatic cysts can be from an infectious or non-infectious source. They are common and usually asymptomatic. This activity reviews the evaluation and treatment of liver cystic lesions and highlights the role of the interprofessional team in evaluating and treating patients with this condition.

Objectives:

  • Describe the etiology of different hepatic cyst lesions.
  • Identify the most common …


Mega‐Analysis Methods In Enigma: The Experience Of The Generalized Anxiety Disorder Working Group, André Zugman, Anita Harrewijn, Elise M. Cardinale, Hannah Zwiebel, Gabrielle F. Freitag, Katy E. Werwath, Janna Marie Bas-Hoogendam, Nynke A. Groenewold, Moji Aghajani, Anderson M. Winkler Jan 2022

Mega‐Analysis Methods In Enigma: The Experience Of The Generalized Anxiety Disorder Working Group, André Zugman, Anita Harrewijn, Elise M. Cardinale, Hannah Zwiebel, Gabrielle F. Freitag, Katy E. Werwath, Janna Marie Bas-Hoogendam, Nynke A. Groenewold, Moji Aghajani, Anderson M. Winkler

School of Medicine Publications

The ENIGMA group on Generalized Anxiety Disorder (ENIGMA-Anxiety/GAD) is part of a broader effort to investigate anxiety disorders using imaging and genetic data across multiple sites worldwide. The group is actively conducting a mega-analysis of a large number of brain structural scans. In this process, the group was confronted with many methodological challenges related to study planning and implementation, between-country transfer of subject-level data, quality control of a considerable amount of imaging data, and choices related to statistical methods and efficient use of resources. This report summarizes the background information and rationale for the various methodological decisions, as well as …


Von Willebrand Factor Levels In The Diagnosis Of Von Willebrand Disease: A Systematic Review And Meta-Analysis, Mohamad A. Kalot, Nedaa Husainat, Abdallah El Alayli, Omar Abughanimeh, Osama Diab, Sammy Tayiem, Bader Madoukh, Ahmad Bilal Dimassi, Aref Qureini, Barbara Ameer Jan 2022

Von Willebrand Factor Levels In The Diagnosis Of Von Willebrand Disease: A Systematic Review And Meta-Analysis, Mohamad A. Kalot, Nedaa Husainat, Abdallah El Alayli, Omar Abughanimeh, Osama Diab, Sammy Tayiem, Bader Madoukh, Ahmad Bilal Dimassi, Aref Qureini, Barbara Ameer

School of Medicine Publications

Von Willebrand Disease (VWD) is associated with significant morbidity as a result of excessive mucocutaneous bleeding symptoms. Patients with VWD can experience easy bruising, epistaxis, gastrointestinal and oral cavity bleeding, as well as heavy menstrual bleeding and bleeding after dental work, surgical procedures, and childbirth. Early diagnosis and treatment is important to prevent and treat these symptoms. We systematically reviewed the accuracy of diagnostic tests using different cut-off values of VWF:Ag and platelet-dependent VWF activity assays in the diagnosis of VWD. We searched Cochrane Central, MEDLINE, and EMBASE for eligible studies. Two investigators screened and abstracted data. Risk of bias …


Assessment Of Combined Modality Therapy For Non-Small-Cell Lung Carcinoma: A Simulation Study Concerning Concurrent Chemo-Brachytherapy, Hadi Rezaei, Hesameddin Mostaghimi, Ali Reza Mehdizadeh Jan 2022

Assessment Of Combined Modality Therapy For Non-Small-Cell Lung Carcinoma: A Simulation Study Concerning Concurrent Chemo-Brachytherapy, Hadi Rezaei, Hesameddin Mostaghimi, Ali Reza Mehdizadeh

Electrical & Computer Engineering Faculty Publications

Although surgery is the treatment of choice for early-stage non-small-cell lung carcinoma, almost two-thirds of patients do not have acceptable pulmonary function for extensive surgeries. The alternative approach for this large group of patients is sublobar resection along with low-dose-rate (LDR) brachytherapy (BT). However, patients with resected lungs have a high risk of recurrence and are often treated with platinum-based (Pt-based) chemotherapy (CT). In this study, we aimed to evaluate the absorbed doses of lung and other thoracic organs, considering concurrent chemo-BT with LDR sources in two modalities: conventional vs. unconventional Pt-based CT. We used the MCNPX code for simulations …


Qu-Brats: Miccai Brats 2020 Challenge On Quantifying Uncertainty In Brain Tumor Segmentation - Analysis Of Ranking Scores And Benchmarking Results, Raghav Mehta, Angelos Filos, Ujjwal Baid, Chiharu Sako, Richard Mckinley, Michael Rebsamen, Katrin Dätwyler, Raphael Meier, Piotr Radojewski, Gowtham Krishnan Murugesan, Sahil Nalawade, Chandan Ganesh, Ben Wagner, Fang F. Yu, Baowei Fei, Ananth J. Madhuranthakam, Joseph A. Maldjian, Laura Daza, Catalina Gómez, Pablo Arbeláez, Chengliang Dai, Shuo Wang, Hadrien Reynaud, Yuan-Han Mo, Elsa Angelini, Yike Guo, Wenjia Bai, Subhashis Banerjee, Lin-Min Pei, Murat Ak, Sarahi Rosas-González, Ilyess Zemmoura, Clovis Tauber, Minh H. Vu, Tufve Nyholm, Tommy Löfstedt, Laura Mora Ballestar, Veronica Vilaplana, Hugh Mchugh, Gonzalo Maso Talou, Alan Wang, Jay Patel, Ken Chang, Katharina Hoebel, Mishka Gidwani, Nishanth Arun, Sharut Gupta, Mehak Aggarwal, Praveer Singh, Elizabeth R. Gerstner, Jayashree Kalpathy-Cramer, Nicholas Boutry, Alexis Huard, Lasitha Vidyaratne, Md. Monibor Rahman, Khan M. Iftekharuddin, Joseph Chazalon, Elodie Puybareau, Guillaume Tochon, Jun Ma, Mariano Cabezas, Xavier Llado, Arnau Oliver, Liliana Valencia, Sergi Valverde, Mehdi Amian, Mohammadreza Soltaninejad, Andriy Myronenko, Ali Hatamizadeh, Xue Feng, Quan Dou, Nicholas Tustison, Craig Meyer, Nisarg A. Shah, Sanjay Talbar, Marc-André Weber, Abhishek Mahajan, Andras Jakab, Roland Wiest, Hassan M. Fathallah-Shaykh, Arash Nazeri, Mikhail Milchenko1, Daniel Marcus, Aikaterini Kotrotsou, Rivka Colen, John Freymann, Justin Kirby, Christos Davatzikos, Bjoern Menze, Spyridon Bakas, Yarin Gal, Tal Arbel Jan 2022

Qu-Brats: Miccai Brats 2020 Challenge On Quantifying Uncertainty In Brain Tumor Segmentation - Analysis Of Ranking Scores And Benchmarking Results, Raghav Mehta, Angelos Filos, Ujjwal Baid, Chiharu Sako, Richard Mckinley, Michael Rebsamen, Katrin Dätwyler, Raphael Meier, Piotr Radojewski, Gowtham Krishnan Murugesan, Sahil Nalawade, Chandan Ganesh, Ben Wagner, Fang F. Yu, Baowei Fei, Ananth J. Madhuranthakam, Joseph A. Maldjian, Laura Daza, Catalina Gómez, Pablo Arbeláez, Chengliang Dai, Shuo Wang, Hadrien Reynaud, Yuan-Han Mo, Elsa Angelini, Yike Guo, Wenjia Bai, Subhashis Banerjee, Lin-Min Pei, Murat Ak, Sarahi Rosas-González, Ilyess Zemmoura, Clovis Tauber, Minh H. Vu, Tufve Nyholm, Tommy Löfstedt, Laura Mora Ballestar, Veronica Vilaplana, Hugh Mchugh, Gonzalo Maso Talou, Alan Wang, Jay Patel, Ken Chang, Katharina Hoebel, Mishka Gidwani, Nishanth Arun, Sharut Gupta, Mehak Aggarwal, Praveer Singh, Elizabeth R. Gerstner, Jayashree Kalpathy-Cramer, Nicholas Boutry, Alexis Huard, Lasitha Vidyaratne, Md. Monibor Rahman, Khan M. Iftekharuddin, Joseph Chazalon, Elodie Puybareau, Guillaume Tochon, Jun Ma, Mariano Cabezas, Xavier Llado, Arnau Oliver, Liliana Valencia, Sergi Valverde, Mehdi Amian, Mohammadreza Soltaninejad, Andriy Myronenko, Ali Hatamizadeh, Xue Feng, Quan Dou, Nicholas Tustison, Craig Meyer, Nisarg A. Shah, Sanjay Talbar, Marc-André Weber, Abhishek Mahajan, Andras Jakab, Roland Wiest, Hassan M. Fathallah-Shaykh, Arash Nazeri, Mikhail Milchenko1, Daniel Marcus, Aikaterini Kotrotsou, Rivka Colen, John Freymann, Justin Kirby, Christos Davatzikos, Bjoern Menze, Spyridon Bakas, Yarin Gal, Tal Arbel

Electrical & Computer Engineering Faculty Publications

Deep learning (DL) models have provided the state-of-the-art performance in a wide variety of medical imaging benchmarking challenges, including the Brain Tumor Segmentation (BraTS) challenges. However, the task of focal pathology multi-compartment segmentation (e.g., tumor and lesion sub-regions) is particularly challenging, and potential errors hinder the translation of DL models into clinical workflows. Quantifying the reliability of DL model predictions in the form of uncertainties, could enable clinical review of the most uncertain regions, thereby building trust and paving the way towards clinical translation. Recently, a number of uncertainty estimation methods have been introduced for DL medical image segmentation tasks. …


The Synthesis And Biological Assessment Of Novel Ursolic Acid Derivatives As Potential Chemotherapeutic Agents For Cancer, Julie Rose Mae Mondala Jan 2022

The Synthesis And Biological Assessment Of Novel Ursolic Acid Derivatives As Potential Chemotherapeutic Agents For Cancer, Julie Rose Mae Mondala

Theses

Glioblastoma (GBM) is considered to be the most biologically aggressive type of brain tumour accounting for approximately 48% of all malignant primary brain tumours. GBM patients diagnosed have poor prognosis with a low five-year survival rate of

The aim of this study was to develop novel UA derivatives to enhance its bioavailability. Nine novel UA derivatives: three different diamine linkers, with Boc-protected and deprotected ends, and with folic acid were designed and synthesized to improve compound activity and/or delivery. The structures of the newly synthesised compounds were confirmed using mass spectrometry, FTIR, 1H NMR and 13C NMR. The structural activity …


Adaptation Des Milieux De Travail Aux Effets Des Changements Climatiques. Tome 2 : Mesures D’Adaptation Destinées Aux Travailleurs Du Québec Les Plus À Risque Vis-À-Vis De La Hausse Des Épisodes De Fortes Chaleurs Liée Aux Changements Climatiques, Bouchra Bakhiyi, Ariane Adam-Poupart, Robert Bourbonnais, Marc-Antoine Busque, Joseph Zayed Jan 2022

Adaptation Des Milieux De Travail Aux Effets Des Changements Climatiques. Tome 2 : Mesures D’Adaptation Destinées Aux Travailleurs Du Québec Les Plus À Risque Vis-À-Vis De La Hausse Des Épisodes De Fortes Chaleurs Liée Aux Changements Climatiques, Bouchra Bakhiyi, Ariane Adam-Poupart, Robert Bourbonnais, Marc-Antoine Busque, Joseph Zayed

Rapports de recherche scientifique

Le présent document correspond au tome 2 du rapport de la recherche intitulé « Adaptation des milieux de travail aux effets des changements climatiques ». Il présente le 2e volet de cette recherche dont l’objectif était de coconstruire des mesures d’adaptation destinées à protéger la santé des travailleurs des 50 professions du Québec les plus à risque vis-à-vis de la hausse des épisodes de fortes chaleurs liée aux Changements climatiques (CC) (désigné par danger A), et ce, en collaboration avec des acteurs clés du secteur de la santé et de la sécurité du travail.

Une revue de la littérature …


Mise À Jour D’Un Outil D’Aide À La Décision Pour L’Estimation Du Risque Lié À Une Exposition À Un Mélange De Substances Chimiques Dans L’Air : Une Nouvelle Version De Mixie, Maude Pomerleau, Philippe Sarazin Jan 2022

Mise À Jour D’Un Outil D’Aide À La Décision Pour L’Estimation Du Risque Lié À Une Exposition À Un Mélange De Substances Chimiques Dans L’Air : Une Nouvelle Version De Mixie, Maude Pomerleau, Philippe Sarazin

Rapports de recherche scientifique

MiXie QC est un outil qui permet d’estimer les risques pour la santé lors d’exposition professionnelle à des mélanges de contaminants. L’utilitaire recense les cas potentiels d’additivité des effets toxiques en croisant des listes d’organes cibles des agents chimiques. Cette étude visait à documenter les modifications apportées dans la version française par l’INRS en 2017 (MiXie FR) en effectuant la comparaison des versions française et québécoise de l’outil. L’accès aux banques de données (BD) des agents et des effets sur la santé des deux versions de MiXie a été fourni par les experts toxicologues responsables de l’utilitaire au Québec et …


Ability To Consent To A Sexual Assault Medical Forensic Examination In Adult Patients With Serious Mental Illness, Leslie W. Miles, Eleanore Knox, Nancy Downing, Julie L. Valentine Jan 2022

Ability To Consent To A Sexual Assault Medical Forensic Examination In Adult Patients With Serious Mental Illness, Leslie W. Miles, Eleanore Knox, Nancy Downing, Julie L. Valentine

Faculty Publications

When a patient reporting a sexual assault (SA) presents with signs and symptoms of serious mental illness (MI), medical providers or forensic examiners may have concerns regarding the ability to legally consent to a sexual assault medical forensic examination (SAMFE). Numerous encounters have occurred where a SAMFE was not offered to a cooperative adult patient because the patient exhibited signs and symptoms of MI. Medical providers and examiners may be motivated by beneficence (believing that treating the patient's MI must take priority over the SAMFE) and/or non-maleficence (a concern that the in-depth SAMFE may worsen the patient's psychological state). Situations …


Dna Methylation Pattern Of Cpg Site In The Promoter Region Of Calca-Alpha Gene As A Putative Epigenetic Biomarker In Neonatal Sepsis- A Prospective Observational Study In South India, Rudra Rupesh Reddy Narsapurapu, Deepti Thandaveshwara, Anshu Kumar Yadav, Akila Prashant Jan 2022

Dna Methylation Pattern Of Cpg Site In The Promoter Region Of Calca-Alpha Gene As A Putative Epigenetic Biomarker In Neonatal Sepsis- A Prospective Observational Study In South India, Rudra Rupesh Reddy Narsapurapu, Deepti Thandaveshwara, Anshu Kumar Yadav, Akila Prashant

Digital Journal of Clinical Medicine

Background: Recently, several studies have been reported on epigenetic modifications of DNA as a predisposing factor for several diseases among neonates and adults. Here we aimed to study the changes in the DNA methylation pattern in the promoter region of the CALCA gene among the neonates suspected to have sepsis in a tertiary care hospital.

Methodology: All the neonates suspected to have sepsis based on the inclusion criteria during the study period were included in the study as cases. Normal healthy neonates were included in the study as controls. Positive cases were isolated from suspected cases based on …


Hip And Knee Joint Angle Patterns And Kicking Velocity In Female And Male Professional Soccer Players: A Principal Component Analysis Of Waveforms Approach, Archit Navandar, Kristof Kipp, Enrique Navarro Jan 2022

Hip And Knee Joint Angle Patterns And Kicking Velocity In Female And Male Professional Soccer Players: A Principal Component Analysis Of Waveforms Approach, Archit Navandar, Kristof Kipp, Enrique Navarro

Exercise Science Faculty Research and Publications

This study used principal component analysis (PCA) of waveforms to extract movement patterns from hip and knee angle time-series data; and determined if the extracted movement patterns were predictors of ball velocity during a soccer kick. Twenty-three female and nineteen male professional soccer players performed maximal effort instep kicks while motion capture and post-impact ball velocities data were recorded. Three-dimensional hip and knee joint angle time-series data were calculated from the beginning of the kicking leg’s backswing phase until the end of the follow-through phase and entered into separate PCAs for females and males. Three principal components (PC) (i.e., movement …


Adaptation Des Milieux De Travail Aux Effets Des Changements Climatiques. Tome 1 : Identification Des Travailleurs Du Québec Les Plus À Risque Vis-À-Vis Des Dangers Prioritaires Liés Aux Changements Climatiques, Bouchra Bakhiyi, Ariane Adam-Poupart, Robert Bourbonnais, Marc-Antoine Busque, Joseph Zayed Jan 2022

Adaptation Des Milieux De Travail Aux Effets Des Changements Climatiques. Tome 1 : Identification Des Travailleurs Du Québec Les Plus À Risque Vis-À-Vis Des Dangers Prioritaires Liés Aux Changements Climatiques, Bouchra Bakhiyi, Ariane Adam-Poupart, Robert Bourbonnais, Marc-Antoine Busque, Joseph Zayed

Rapports de recherche scientifique

Les changements climatiques (CC) constituent une menace reconnue et admise pour les travailleurs. Pour réduire leur vulnérabilité vis-à-vis des dangers liés aux CC, l’adaptation des milieux de travail est devenue incontournable. Cette recherche se propose de coconstruire des mesures d’adaptation qui permettraient de protéger la santé et l’intégrité des travailleurs du Québec malgré les répercussions appréhendées des CC.

Les travaux ont été réalisés en deux volets :

  • Le premier volet avait pour objectif l’identification des travailleurs du Québec les plus à risque vis-à-vis des dangers prioritaires liés aux CC ;
  • Le deuxième volet a visé la coconstruction des mesures d’adaptation …


Effect Of Moderate Sedation Regimen (Diazepam, Meperidine, And Hydroxyzine) Dosages On Patient Behavior And Outcome Of Sedation In Pediatric Dentistry: A Retrospective Study, Taibah M A M J Albaker Jan 2022

Effect Of Moderate Sedation Regimen (Diazepam, Meperidine, And Hydroxyzine) Dosages On Patient Behavior And Outcome Of Sedation In Pediatric Dentistry: A Retrospective Study, Taibah M A M J Albaker

Theses and Dissertations

Purpose: To determine if behavior at consult visit and sedation medication dosages are associated with the success of sedation visits and patient’s behavior using the diazepam, meperidine, and hydroxyzine (DMH) regimen.

Methods: A retrospective chart review was conducted of 324 VCU Pediatric Dentistry Department patients who underwent 404 moderate conscious sedation visits with DMH regimen from April 2017 to June 2022. Sedation visits were graded as “Successful” or “Unsuccessful” and “Good” or “Poor behavior.” The primary variables of interest included Frankl behavior at consult visit and the sedation medication dosages. Logistic regression models were used to determine if these factors …


Landmark Mediation Survival Analysis Using Longitudinal Surrogate, Jie Zhou, Xun Jiang, H Amy Xia, Brian P Hobbs, Peng Wei Jan 2022

Landmark Mediation Survival Analysis Using Longitudinal Surrogate, Jie Zhou, Xun Jiang, H Amy Xia, Brian P Hobbs, Peng Wei

Faculty, Staff and Student Publications

Clinical cancer trials are designed to collect radiographic measurements of each patient's baseline and residual tumor burden at regular intervals over the course of study. For solid tumors, the extent of reduction in tumor size following treatment is used as a measure of a drug's antitumor activity. Statistical estimation of treatment efficacy routinely reduce the longitudinal assessment of tumor burden to a binary outcome describing the presence versus absence of an objective tumor response as defined by RECIST criteria. The objective response rate (ORR) is the predominate method for evaluating an experimental therapy in a single-arm trial. Additionally, ORR is …


Opioid Medication Use And Blood Dna Methylation: Epigenome-Wide Association Meta-Analysis, Mikyeong Lee, Roby Joehanes, Daniel L. Mccartney, Minjung Kho, Anke Hüls, Annah B. Wyss, Chunyu Liu, Rosie M. Walker, Sharon L.R. Kardia, Thomas S. Wingo, Adam Burkholder, Jiantao Ma, Archie Campbell, Aliza P. Wingo, Tianxiao Huan, Sinjini Sikdar, Amena Keshawarz, David A. Bennett, Jennifer A. Smith, Kathryn L. Evans, Daniel Levy, Stephanie J. London Jan 2022

Opioid Medication Use And Blood Dna Methylation: Epigenome-Wide Association Meta-Analysis, Mikyeong Lee, Roby Joehanes, Daniel L. Mccartney, Minjung Kho, Anke Hüls, Annah B. Wyss, Chunyu Liu, Rosie M. Walker, Sharon L.R. Kardia, Thomas S. Wingo, Adam Burkholder, Jiantao Ma, Archie Campbell, Aliza P. Wingo, Tianxiao Huan, Sinjini Sikdar, Amena Keshawarz, David A. Bennett, Jennifer A. Smith, Kathryn L. Evans, Daniel Levy, Stephanie J. London

Mathematics & Statistics Faculty Publications

Aim: To identify differential methylation related to prescribed opioid use. Methods: This study examined whether blood DNA methylation, measured using Illumina arrays, differs by recent opioid medication use in four population-based cohorts. We meta-analyzed results (282 users; 10,560 nonusers) using inverse-variance weighting. Results: Differential methylation (false discovery rate <0.05) was observed at six CpGs annotated to the following genes: KIAA0226, CPLX2, TDRP, RNF38, TTC23 and GPR179. Integrative epigenomic analyses linked implicated loci to regulatory elements in blood and/or brain. Additionally, 74 CpGs were differentially methylated in males or females. Methylation at significant CpGs correlated with gene expression in blood and/or brain. Conclusion: This study identified DNA …


The Dynamics Of Cross-Sector Collaboration In Centralized Disaster Governance: A Network Study Of Interorganizational Collaborations During The Mers Epidemic In South Korea, M. Ku, Ahreum Han, Keon Hyung Lee Jan 2022

The Dynamics Of Cross-Sector Collaboration In Centralized Disaster Governance: A Network Study Of Interorganizational Collaborations During The Mers Epidemic In South Korea, M. Ku, Ahreum Han, Keon Hyung Lee

Health Care Administration Faculty Research

The debate continues as to which governance structure is most appropriate for collaborative disaster response, particularly between centralization and decentralization. This article aims to contribute to this debate by analyzing the structural characteristics of a multisectoral network that emerged and evolved under strong state control during the 2015 outbreak of Middle East respiratory syndrome-coronavirus (MERS) in South Korea. This study particularly focuses on the evolution of intra- and inter-sectoral collaboration ties in the network. The data for the study were collected through a content analysis of government documents and news articles. Using social network analysis, the authors found that the …


Authorship Equity And Gender Representation In Global Oncology Publications, Paula Hornstein, Hubert Tuyishime, Miriam Mutebi, Nwamaka Lasebikan, Fidel Rubagumya, Temidayo Fadelu Jan 2022

Authorship Equity And Gender Representation In Global Oncology Publications, Paula Hornstein, Hubert Tuyishime, Miriam Mutebi, Nwamaka Lasebikan, Fidel Rubagumya, Temidayo Fadelu

General Surgery, East Africa

Purpose: Authorship gender disparities persist across academic disciplines, including oncology. However, little is known about global variation in authorship gender distribution.

Methods: This retrospective cross-sectional study describes the distribution of author gender as determined from the first name across variables such as authorship position (first, middle, and last), country region, and country income level. The 608 articles with 5,302 authors included in this analysis were published in the Journal of Clinical Oncology Global Oncology, from its inception in October 2015 through March 2020. Primary outcome measure was author gender on the basis of first name probabilities assessed by …


Rapid Student Assessment And Review Program (R-Star) Training Manual ©, Nicole M. Sleddens Jan 2022

Rapid Student Assessment And Review Program (R-Star) Training Manual ©, Nicole M. Sleddens

Manuals: Physical Therapy

No abstract provided.


Development Of The Sexual Spring Planning Manual, Hannah Belle Aldridge Jan 2022

Development Of The Sexual Spring Planning Manual, Hannah Belle Aldridge

Occupational Therapy Doctoral Capstones

Sexual activity plays an essential role in many individuals' lives, but some people are unable to participate in the activity as they would like to due to many underlying causes. Issues with sexuality are commonly underdiagnosed and overlooked, given the social stigmas that make individuals feel ashamed and embarrassed to discuss it with their medical providers. As of 2019, "sexual dysfunction is estimated to be around 30-50% in the general population” (Verbeek & Hayward, 2019). This number continues to rise; therefore, education must be provided to these individuals to receive appropriate care and treatment. Sexual health is typically only addressed …


Promoting Inclusivity For Students With Disabilities To Improve Their Occupational Performance At The Collegiate Level, Erica Basca Jan 2022

Promoting Inclusivity For Students With Disabilities To Improve Their Occupational Performance At The Collegiate Level, Erica Basca

Occupational Therapy Doctoral Capstones

Students with disabilities enrolled in post-secondary institutions are increasing in numbers so that students develop the skills needed to achieve a career and live independently. Barriers at the collegiate level include difficulties communicating their concerns with the faculty, lack of mentorship from their advisors, and having no prior knowledge about student organizations/services. Students also experienced daily stressors due to the physical demands of their classroom environment, the pressures of socialization, and the want of acceptance (Hong, 2015). Research by Love (2016) observed the barriers that prevent students with disabilities from engaging in leisure and social activities. The barriers included physical …


Sidewalks: Environmental Facilitators To Promote Older Adult Community Participation, Hailey Godfrey Thomas Jan 2022

Sidewalks: Environmental Facilitators To Promote Older Adult Community Participation, Hailey Godfrey Thomas

Occupational Therapy Doctoral Capstones

According to the Administration of Community Living (2021), between 2009 and 2019 there was a 34 percent increase of adults aged 60 and older, totaling 74.6 million older adults in the United States. With the increase in the aging population an emphasis on accessible environments to promote inclusion is necessary. The American Association of Retired Persons found 80 percent of Americans desire a community that has sidewalks and places to walk (2014). Sidewalks are an integral aspect to improving community participation and the quality of life of older adults. Sidewalks can assist in enhancing social interactions, physical activity, and community …


Serve Those Who Served Us: Life Skills Program Development To Decrease Homelessness In The Veteran Population, Hannah Hale Malone Jan 2022

Serve Those Who Served Us: Life Skills Program Development To Decrease Homelessness In The Veteran Population, Hannah Hale Malone

Occupational Therapy Doctoral Capstones

According to the National Coalition for the Homeless, veterans represent one fourth of the entire homeless population, which is approximately 200,000 individuals each night (NCH, 2009). Within Arkansas, it is estimated that more than 500 are homeless throughout the state (Jared, 2021). These veterans are 50% more likely to become homeless than other Americans due to poverty, shortage of affordable housing, lack of social support networks, a number of stress-related conditions, substance abuse, and the disadvantage of their military occupation and training not being transferable when competing for employment in the civilian workforce (VA Office of Inspector General, 2012). Unfortunately, …


Program Development: An Adaptive Sports Program For Children With Disabilities To Promote Occupational Engagement, Haylee Whitehurst Jan 2022

Program Development: An Adaptive Sports Program For Children With Disabilities To Promote Occupational Engagement, Haylee Whitehurst

Occupational Therapy Doctoral Capstones

Very little is known about the correlation between children with disabilities and the benefits of participation in adaptive sports. It is well known what the benefits of sports are for typically developing children. Research shows the need for growth in the adaptive sports area due to the information known about typically developing children. People are often unaware, but people with disabilities are the United States largest minority group and the only group that you can join at any moment (Inclusive Playgrounds, n.d.). According to Inclusive Playgrounds (n.d.), 6.7 million school-age children live with disabilities in the United States. Camp Aldersgate …


Development Of A Vocational Skills Program For An Adult Day Treatment Center, Faith Jones Jan 2022

Development Of A Vocational Skills Program For An Adult Day Treatment Center, Faith Jones

Occupational Therapy Doctoral Capstones

Approximately 6.5 million people in the United States have an intellectual disability (Special Olympics, 2020). Worldwide, approximately one percent of the population has an intellectual disability (Mauliket al., 2011). For an individual to be diagnosed with an intellectual disability, they must display significant deficits in both intellectual functioning and adaptive behavior that has an onset prior to 22 years of age. A score below 70 to 75 on an IQ test indicates that an intellectual functioning deficit is present (AAIDD, n.d.). Employment plays a significant role in community engagement and social interaction for many people throughout the world; however, historically, …


Incorporating An Occupational Balance Component Into A Community Physical Education In The Park Youth Program, Chineche Lilian Aniemena Jan 2022

Incorporating An Occupational Balance Component Into A Community Physical Education In The Park Youth Program, Chineche Lilian Aniemena

Occupational Therapy Doctoral Capstones

The purpose of the Doctoral Capstone Project was to incorporate an evidence-based occupational balance component into the “Physical Education (PE) in the Park” program to promote healthy behaviors and weight loss, and prevent obesity.