Medicine and Health Sciences Commons^™

Does Acupuncture/Dry Needling Improve Pain And Itch In Abnormal Hypertrophic Scars, Catherine Tuckey

Theses

This research program investigated the use of acupuncture intervention as an adjunct for hypertrophic scar (HTS) management. Mechanistic evidence from ex vivo and animal studies suggests that acupuncture has the potential to modulate neurogenic inflammation to influence pain and itch associated with HTS. Further, acupuncture may mediate non-neuronal cells involved in the proliferation and remodelling stage of healing to promote scar maturation. Previous studies using acupuncture for scar management demonstrated positive outcomes, however low-quality clinical trials and case studies provide limited evidence for treatment benefit.

A treatment protocol was designed to investigate the effects of locally applied acupuncture compared to …

Monitoring The Systemic Immune System To Understand And Improve The Efficacy Of Immunotherapy For Metastatic Osteosarcoma, Justin Edward Markel

Graduate Theses, Dissertations, and Problem Reports (ETD)

Osteosarcoma (OS) is a complex tumor with no effective targeted therapies due to its genomic heterogeneity and pleomorphism. The immune response it creates, particularly against metastatic lesions, is considerable; however, various suppressive mechanisms induced by the tumor prohibit its effectiveness. The presence of infiltrating lymphocytes suggests that therapeutic disinhibition through checkpoint blockade could increase antitumor immunity, though none have been successful in clinical trials. The complexities of the immune response to OS tumors have yet to be unraveled; however, there is evidence to suggest that cell-mediated immunity (CMI, specifically T cells, Natural Killer [NK] cells, and myeloid-lineage cells [MLCs]) plays …

Instrumental And Emotional Social Support Intention And Utilization Among Pregnant And Postpartum Women During The Covid-19 Pandemic, Gracie Minks

All Master's Theses

Postpartum depression impacts 1 in 7 women across the U.S. As a whole population, between 10-16% of women are impacted by maternal depression during pregnancy or the first year postpartum. Those who experience postpartum depression are at risk for repeated depressive episodes and a lower quality of life over time. The postnatal period may reflect the most vulnerable time for mental health concerns such as anxiety and depression. Fear, judgment, and perceived criticism are commonly named as barriers that delay the mobilization of support.

There is a prevailing perception that postpartum depression is a normal part of motherhood which may …

Education And Awareness Of Workplace Hazards: An Educational Intervention For First Responder Trainees, Emily Portune

All Master's Theses

First responder paramedics, emergency medical technicians (EMTs), and firefighters provide emergency services to communities everywhere, often in life-threatening circumstances. At the same time, these first responders face high-stress life and death situations and may also endure unique workplace hazards like racism, sexual harassment and discrimination, verbal and physical patient assault, and extreme sleep deprivation. These hazards make prehospital providers vulnerable to mental illness, a fact proven by preexisting research that found more than 85% of first responders reported negative mental health symptoms and outcomes directly related to their career. Not only are prehospital providers at high risk of mental illness; …

Knee Braces And Foot Orthoses Multimodal Treatment Of Medial Knee Osteoarthritis, Xavier Robert-Lachaine, Yoann Dessery, Étienne L. Belzile, Philippe Corbeil

Études primaires

Background

Knee braces and lateral wedge foot orthoses are two treatment options recommended for medial knee osteoarthritis, but the combination of both of them could further improve their effectiveness.

Research question

The aim was to evaluate whether the combination of lateral wedge foot orthoses with two types of knee brace enhances the biomechanical effects and pain relief during the stance phase of gait while maintaining comfort.

Methods

Ten patients with medial knee osteoarthritis were fitted with a standard valgus brace, an unloader brace with valgus and external rotation functions, and 7° lateral wedge foot orthoses. The pain relief, comfort, kinematics …

Morphologic Clustering Of Earcanals Using Deep Learning Algorithm To Design Artificial Ears Dedicated To Earplugs Attenuation Measurement, Bastien Poissenot-Arrigoni, Chun Hong Law, Djamal Berbiche, Franck Sgard, Olivier Doutres

Études primaires

Designing earplugs adapted for the widest number of earcanals requires acoustical test fixtures (ATFs) geometrically representative of the population. Most existing ATFs are equipped with unique sized straight cylindrical earcanals, considered representative of average human morphology, and are therefore unable to assess how earplugs can fit different earcanal morphologies. In this study, a methodology to cluster earcanals as a function of their morphologies with the objective of designing artificial ears dedicated to sound attenuation measurement is developed and applied to a sample of Canadian workers’ earcanals. The earcanal morphologic indicators that correlate with the attenuations of six models of commercial …

Occupational Exposure To Wood Dust And The Burden Of Nasopharynx And Sinonasal Cancer In Canada, Amirabbas Mofidi, Emile Tompa, Christina Kalcevich, Christopher Mcleod, Martin Lebeau, Chaojie Song, Joanne Kim, Paul A. Demers

Études primaires

Background: Millions of workers around the world are exposed to wood dust, as a by-product of woodworking. Nasopharynx cancers (NPCs) and sinonasal cancers (SNCs) are two cancers that can be caused by occupational exposure to wood dust, but there is little evidence regarding their burden in Canada. Objective: the aim of this study was to estimate the incidence and economic burden of newly diagnosed cases of NPC and SNC in 2011 in Canada, attributable to occupational exposures to wood dust. Methods: calculating the incidence of cancer attributable to occupational exposure involved three steps of defining relative risk, assessing the prevalence …

Risk-Based Inspection Applied To Two-Post Above-Ground Automotive Lifts, Damien Burlet-Vienney, François Gauthier, Bertrand Galy

Études primaires

The safe use of two-post above-ground automotive lifts (2PAG lifts) has received particular attention in the province of Québec (Canada) following the death of a young mechanic. The inspection and preventive maintenance of this equipment is a problem highlighted in accident investigation reports and by representatives of the sector. Therefore, the work presented in this article aimed at proposing a complete and detailed inspection grid for 2PAG lifts by establishing an exhaustive list of verification criteria, baseline states and the inspection frequency for each criterion according to their criticality. The grid was built from standards, existing grids, manufacturers’ manuals, interviews …

Stay At Work After A Period Of Disability Due To An Occupational Injury: A Complex Process Marked By Social Exchanges, Alexandra Lecours, Marie-José Durand, Marie-France Coutu, Charles Groleau, Roxanne Bédard-Mercier

Études primaires

Purpose Rooted in a social exchange lens, this study aimed to explore the interactions between the factors influencing stay at work after a period of disability due to an occupational injury. Methods Based on a descriptive interpretative research design, interviews with 15 participants (i.e., representatives of workers, workplaces, insurers, and the health care system) were conducted to gather their perspectives about stay at work. Qualitative data was analyzed through thematic analysis. Results Ten different factors interacting together and influencing stay at work were identified. These factors prevail either during stay at work or previously. They are either related to the …

Health Policy, Equity, And The Lead Poisoning Crisis: A Conversation With Dr. Mona Hanna-Attisha, Mona Hanna-Attisha

Center for Policy Research

Dr. Mona Hanna-Attisha delivered the 33rd Annual Herbert Lourie Memorial Lecture on Health Policy on Thursday, September 23, 2021. This year's lecture was titled, "Health Policy, Equity, and the Lead Poisoning Crisis: A Conversation with Dr. Mona Hanna-Attisha"

Mona Hanna-Attisha, MD, MPH, FAAP, is founder and director of the Michigan State University and Hurley Children’s Hospital Pediatric Public Health Initiative, an innovative and model public health program in Flint, Michigan.

A pediatrician, scientist, activist, and author, Dr. Hanna-Attisha has testified three times before the United States Congress and was awarded the Freedom of Expression Courage Award by PEN America. She …

Associations Between Mothers’ Use Of Food To Soothe, Feeding Mode, And Infant Weight During Early Infancy, Megan K. Hupp, Peggy C. Papathakis, Suzanne Phelan, Alison K. Ventura

Kinesiology and Public Health

Weight status and rate of weight gain in the first six months postpartum are strong predictors of later obesity; thus, infant feeding practices are an important target for obesity prevention efforts. The use of food to soothe (FTS) is associated with less-favorable eating habits and weight outcomes for older infants and children. However, few studies have examined correlates of use of FTS during early infancy. The primary aim of this cross-sectional study was to explore associations between use of FTS and infant weight status in the first 6 months postpartum. A secondary aim was to identify the combination of maternal …

Effect Of Care Environment On Educational Attainment Among Orphaned And Separated Children And Adolescents In Western Kenya, Dorothy Apedaile, Allison Delong, Edwin Sang, David Ayuku, Lukoye Atwoli, Omar Galárraga, Paula Braitstein

Internal Medicine, East Africa

Background: There are approximately 140 million orphaned and separated children (OSCA) around the world. In Kenya, many of these children live with extended family while others live in institutions. Despite evidence that orphans are less likely to be enrolled in school than non-orphans, there is little evidence regarding the role of care environment. This evidence is vital for designing programs and policies that promote access to education for orphans, which is not only their human right but also an important social determinant of health. The purpose of this study was to compare educational attainment among OSCA living in Charitable …

The Dangers Of Aces, Olivia Carey, Thea Forrest, Adna Abdi

MaineHealth Maine Medical Center

ACEs stands for Adverse Childhood Experiences, included (but not limited to) physical, emotional, and sexual abuse, substance abuse, neglect, dysfunctional families, and mental illness'. ACEs impacts childhood development and increases chances of future health implications.

Mapping Melanoma Risk And Locating High-Need Regions For Dermoscopy And Skin Biopsy Training, Calla Hladky, Madeline Prentiss, Henry Stoddard, Kathryn Stevens, Elizabeth Seiverling, Peg Cyr

MaineHealth Maine Medical Center

Background- Dermoscopy and skin biopsy trainings have been shown to help improve PCPs’ knowledge of and confidence in detecting skin cancer. The goal of this project was to determine where to focus training efforts in order to maximize our impact and reach regions that face the highest burden of melanoma in the state.

Factors Influencing Fellowship Training Among Ophthalmology Residents: A Pilot Study., Craig N Czyz, Rahul Kashyap, Laura L Wayman

Medical Education Articles

OBJECTIVE: There has been an increase in ophthalmology fellowship training programs and applicants. The current ophthalmology literature lacks any recent study examining factors influencing residents' decisions to pursue subspecialty fellowship training.

METHODS: An anonymous, 16-item survey was distributed to residents from a convenience sample of ophthalmology residency programs by their program directors or administrators.

RESULTS: A total of 72 residents and 9 interns from 9 distinct programs completed the survey. Eighty-two percent of respondents reported they have either applied or will apply for a fellowship position. Gender and race showed no significant association with fellowship application. Respondents perceived that obtaining …

Psycholinguistic Profiling Of Children With Sluggish Cognitive Tempo, Kirsten M. Russell, Sean M. Redmond, Andrea C. Ash

Faculty Publications

Language disorders are frequently comorbid with attention deficit/hyperactivity disorder (ADHD). Sluggish cognitive tempo (SCT),a second attention disorder, may potentially explain some of the links between language disorders and ADHD. In this study we examined the psycholinguistic abilities of 207 children (mean age 7;10) with and without clinically significant levels of SCT symptoms to determine the degree to which symptoms of language disorder co-occur in cases of SCT. Analyses of children’s tense-marking, nonword repetition, and sentence recall indicated that deficits in these areas were not associated with SCT. Instead, SCT appears to be more closely aligned with features of social (pragmatic) …

Comparison Of Gps Imputation Methods In Environmental Health Research, Sungsoon Hwang, Kashica Webber-Ritchey, Elizabeth A. Moxley

Faculty Articles, Papers, and Other Scholarship

Assessment of personal exposure in the external environment commonly relies on global positioning system (GPS) measurements. However, it has been challenging to determine exposures accurately due to missing data in GPS trajectories. In environmental health research using GPS, missing data are often discarded or are typically imputed based on the last known location or linear interpolation. Imputation is said to mitigate bias in exposure measures, but methods used are hardly evaluated against ground truth. Widely used imputation methods assume that a person is either stationary or constantly moving during the missing interval. Relaxing this assumption, we propose a method for …

Prevalence Versus Evidence: A Closer Look At The Research Available For Serving Children Exposed To Maltreatment And A Response To Hyter's Call For Trauma-Informed Care, Savanah Gayaldo, Allison Gladfelter

Faculty Articles, Papers, and Other Scholarship

Purpose:

In an October 2021 post of The ASHA LeaderLive, Dr. Yvette Hyter emphasized the need for trauma-informed services for children exposed to maltreatment in the wake of the COVID-19 pandemic. Inspired by her call, we discuss how the pandemic created a high-risk context for maltreatment, the speech-language pathologists' (SLPs') role in prevention and intervention, reflect on the gap in evidence for maltreatment within empirical journals aimed at the speech-language pathology audience, and reiterate Hyter's call for trauma-informed care as a guide for clinicians serving children exposed to maltreatment.

Method:

We searched for empirical evidence within journals aimed at …

Review Of Evidence For Environmental Causes Of Uveal Coloboma, Evan B Selzer, Delphine Blain, Robert B Hufnagel, Philip J Lupo, Laura E Mitchell, Brian P Brooks

Faculty, Staff and Student Publications

Uveal coloboma is a condition defined by missing ocular tissues and is a significant cause of childhood blindness. It occurs from a failure of the optic fissure to close during embryonic development and may lead to missing parts of the iris, ciliary body, retina, choroid, and optic nerve. Because there is no treatment for coloboma, efforts have focused on prevention. While several genetic causes of coloboma have been identified, little definitive research exists regarding the environmental causes of this condition. We review the current literature on environmental factors associated with coloboma in an effort to guide future research and preventative …

Investigation Of Urinary Metabolomics In A Phase I Hookworm Vaccine Trial In Gabon, Madeleine Eunice Betouke Ongwe, Yoanne D Mouwenda, Koen A Stam, Peter G Kremsner, Bertrand Lell, David Diemert, Jeff Bethony, Maria E Bottazzi, Peter J Hotez, Remko V Leeuwen, Martin P Grobusch, Ayola A Adegnika, Oleg A Mayboroda, Maria Yazdanbakhsh

Center for Medical Ethics and Health Policy Staff Publications

Metabolomics provides a powerful tool to study physiological changes in response to various perturbations such as vaccination. We explored whether metabolomic changes could be seen after vaccination in a phase I trial where Gabonese adults living either in rural or semi-urban areas received the subunit hookworm vaccine candidates (Na-GST-1 and Na-APR-1 (M74) adjuvanted with Alhydrogel plus GLA-AF (n = 24) or the hepatitis B vaccine (n = 8) as control. Urine samples were collected and assayed using targeted 1H NMR spectroscopy. At baseline, a set of metabolites significantly distinguished rural from semi-urban individuals. The pre- and post-vaccination comparisons indicated significant …

Unexpected And Usual Breaks' Impact On Body Composition In College Athletes, Aston Dommel

All ETDs from UAB

Body composition is an important factor that determines athletic performance. At the elite level, margins of victory are narrow, with small changes in performance making the difference between victory and defeat. Changes in body composition affect performance, in both improvements and decrements. Athletes regularly experience breaks from structured activity and resources caused by expected circumstances (school breaks, off-season) and unexpected circumstances (injury, COVID-19). Due to differences in diet, physical activity, and other factors, breaks may cause changes in body composition that can hinder or help the athlete upon return to structured resources. Currently, there is a plethora of cross-sectional research …

Tooth Agenesis: Prevalence And Pattern Among Different Ethnicities, Gabrielle Coe

All ETDs from UAB

Tooth agenesis is one of the most common developmental anomalies in humans and is defined as the failure of tooth development or odontogenesis. Prevalence of non-syndromic tooth agenesis has a reported range of 1.6-36.5% and varies by gender, ethnicity, and location. While tooth agenesis is well studied, information within ethnic groups requires further investigation. In this study, dental records of 3033 patients of the UAB School of Dentistry were evaluated to identify and categorize missing teeth by ethnicity and gender. Data analysis was conducted with Chi-square or Fisher’s exact test, with a two-sided significance level of 0.05. An overall prevalence …

Effects Of Covid-19 On Ventilator Associated Events (Vaes) Due To Multi-Drug Resistant Organisms (Mdros), Jeffery Asiedu

All ETDs from UAB

The aim of this study was to assess the association between the coronavirus disease (COVID-19) and the odds of ventilator associated events (VAEs). Retrospective analysis on prospectively collected data from 11,307 patients admitted to the intensive care unit (ICU) at the University of Alabama at Birmingham hospital between January 2018 and June 2022 was used. Outcomes considered were Any VAE, IVAC/PVAP, PVAP and MDRO PVAP. Crude and adjusted logistic regression models were used to evaluate the association between COVID-19 and the outcome variables. When a patient has Prior COVID-19, the odds of getting any VAE during the delta period is …

The Association Between Metabolically Healthy Obesity And Coronary Heart Disease Among Regards Study Participants, Kiara N. Aaron

All ETDs from UAB

A major obstacle to the advancement of our understanding of the metabolically healthy obesity (MHO) phenotype is the inconsistent definition of metabolic health and obesity among studies. A harmonized definition of MHO in adults has been proposed based on the diagnosis of obesity (BMI > 30 k/m2) and meeting the cardio-metabolic criteria for triglycerides, high-density lipoprotein (HDL) cholesterol, systolic blood pressure (SBP), diastolic blood pressure (DBP), no antihypertensive treatment, fasting blood glucose, and no drug treatment with glucose-lowering agents. In addition, waist circumference can be associated with increased disease risk when WC is >94 cm in men and >80 cm in …

The Role Of Complement C3 In Iga Nephropathy, Sarah Elizabeth Coffee

All ETDs from UAB

IgA nephropathy is an autoimmune disease characterized by glomerular IgA1- containing immunodeposits. These immunodeposits are enriched for aberrantly glycosylated IgA1 bound by IgG autoantibodies and contain complement component C3. Current research suggests a multi-hit disease pathogenesis: IgAN patients have elevated serum levels of IgA1 missing galactose in some hinge region O-glycans; this galactosedeficient IgA1 is recognized by IgG autoantibodies resulting in formation of circulating immune complexes; some of these complexes deposit in the glomeruli and induce kidney injury. As there is no disease-specific treatment, many patients progress to kidney failure. In this master’s thesis I sought to assess whether C3 …

Child Schooling And Other Factors Associated With Covid-19 Vaccine Hesitancy Among Adults That Had Not Been Vaccinated In The Fall Of 2021, Ryan M. Fischer

All ETDs from UAB

Although COVID-19 vaccine hesitancy decreased noticeably over time during the first months of 2021, there was still a high degree of vaccine hesitancy in the United States at the time that the vaccine first became available to adolescents. Data from Phase 3.2 of the U.S. Census Bureau’s Household Pulse Survey (July 21 – October 11th, 2021) was used to conduct an ecological study on COVID-19 vaccine hesitancy that investigated associations between vaccine hesitancy and socio-demographic characteristics as well as child school type (public school, private school, homeschool). Subjects that had not received a vaccine at the time of survey data …

A Prospective Randomized Clinical Trial To Compare Side Access Mucosal Releasing Incision (Samri) And Sulcular Tunnel Access And Root Coverage Procedures With Coronally Advanced Flap And Acellular Dermal Matrix (Adm) To Treat Teeth With Gingival Recession And Lack Of Adequate Keratinized Tissue. A Pilot Study, Karen Younghee Jo

All ETDs from UAB

Aims. The primary aim of this randomized, blinded, controlled clinical trial was to compare clinical and patient-centered outcomes obtained following soft tissue grafting utilizing the Side Access Mucosal Releasing Incision (SAMRI) or Sulcular Tunnel Access (STA) procedures with acellular dermal matrix (ADM) and coronal flap advancement to treat Miller Class I and II recession defects on single rooted teeth. Methods. Five patients and eight recession defect sites with Miller Class I or II gingival recession and £ 2mm of keratinized tissue at each site were randomly divided into two groups (A: SAMRI, B: STA) and were treated and evaluated for …

Clinical Decision-Making: A Survey On The Influence Of Specialty And Experience In Treatment Planning Of Multidisciplinary Cases, Rawan Oueis

All ETDs from UAB

Objective: to evaluate the effect of specialization and experience on treatment planning multidisciplinary cases. Materials and Methods: A survey presenting 7 clinical scenarios and their potential treatment plans was designed and disseminated electronically to five groups of dentists (general dentists, endodontists, prosthodontists, orthodontists, periodontists). 509 responses were collected and analyzed for distribution and levels of agreement. Results: A moderate kappa was found (k=0.4-0.6) between endodontists and periodontists and within endodontists. There was no agreement on the type of restorations that are used between different specialties and within specialties of different years of experience. Conclusion: Specialists and general dentists use a …

Study Of Microrna-23a Cluster In Bone Formation, Revati Suryawanshi

All ETDs from UAB

The differentiation of mesenchymal stem cells to pre-osteoblasts, lies upon various transcription factors and physiological signaling, but is also governed by the micro-RNA-23a cluster. The miR-23a cluster has miR-23a, miR-27a and miR-24-2 transcribed from a single promoter as a sole RNA primary transcript. Its effects have been observed in embryonic stem cells, mesenchymal stem cells (MSCs), and in cancer (1-2). It regulates the lineage commitment of MSCs. (3). With respect to bone formation, miR-23a cluster is involved MSCs commitment to and osteoblast maturation (4). Here, through in vivo and in vitro experiments, we report that knock down of microRNA-23a cluster …

Evaluation Of Ventilation Performance And Respirable Particles In Food Trucks, Dong Lee Yang

All ETDs from UAB

Background: The food truck industry in the U.S. has rapidly expanded, with an average growth of 7.9 % from 2017 to 2022. Food truck workers are potentially exposed to harmful airborne contaminants such as particulate matter (PM) and aldehydes produced during cooking process. Kitchen exhaust hoods are designed to capture the cooking emissions, but it is not well understood whether the commercial kitchen exhaust hoods in food trucks are properly, efficiently operated to reduce the workers' exposure to such harmful contaminants. The purpose of the study was to evaluate food truck workers' exposure to respirable particulates generated from cooking process …