Medicine and Health Sciences Commons^™

Viloxazine, A Non-Stimulant Norepinephrine Reuptake Inhibitor, For The Treatment Of Attention Deficit Hyperactivity Disorder: A 3 Year Update., Hannah W. Haddad, Paul B. Hankey, Jimin Ko, Zahaan Eswani, Pravjit Bhatti, Amber N. Edinoff, Adam M. Kaye, Alan David Kaye

School of Pharmacy Faculty Articles

Attention deficit hyperactivity disorder (ADHD) is the most common neurodevelopmental disorder in childhood. Current treatment options for ADHD include pharmacological treatment (stimulants, non-stimulants, anti-depressants, anti-psychotics), psychological treatment (behavioral therapy with or without parent training, cognitive training, neurofeedback), and complementary and alternative therapies (vitamin supplementation, exercise). Central nervous system (CNS) stimulants are the primary pharmacological therapy used in treatment; however, these stimulant drugs carry a high potential for abuse and severe psychological/physical dependence. Viloxazine, a non-stimulant medication without evidence of drug dependence, is a selective norepinephrine reuptake inhibitor that has historically been prescribed as an anti-depressant medication. The extended-release (ER) form …

Buprenorphine And Its Formulations: A Comprehensive Review., Salomon Poliwoda, Nazir Noor, Jack S. Jenkins, Cain W. Stark, Mattie Steib, Jamal Hasoon, Giustino Varrassi, Ivan Urits, Omar Viswanath, Adam M. Kaye, Alan David Kaye

School of Pharmacy Faculty Articles

Buprenorphine, a novel long-acting analgesic, was developed with the intention of two purposes: analgesia and opioid use disorder. Regarding its pharmacodynamics, it is a partial agonist at mu receptors, an inverse agonist at kappa receptors, and an antagonist at delta receptors. For the purpose of analgesia, three formulations of buprenorphine were developed: IV/IM injectable formulation (Buprenex®), transdermal patch formulation (Butrans®), and buccal film formulation (Belbuca®). Related to opioid dependence, the formulations developed were subcutaneous extended release (Sublocade®), subdermal implant (Probuphine®), and sublingual tablets (Subutex®). Lastly, in order to avoid misuse of buprenorphine for opioid dependence, two combination formulations paired with …

Midazolam Nasal Spray To Treat Intermittent, Stereotypic Episodes Of Frequent Seizure Activity: Pharmacology And Clinical Role, A Comprehensive Review., Elyse M. Cornett, Meskerem A. Nemomsa, Bailey Turbeville, Matthew A. Busby, Jessica S. Kaye, Aaron J. Kaye, Joohee Choi, Giovanni F. Ramírez, Giustino Varrassi, Adam M. Kaye, Alan David Kaye, James Wilson, Latha Ganti

School of Pharmacy Faculty Articles

An intranasal formulation of midazolam, Nayzilam, has been FDA-approved to treat intermittent, stereotypic episodes of frequent seizure activity. Nayzilam is easy to administer and can quickly treat seizures that occur outside of the hospital. The intra-nasal route of administration allows non-medical personal to administer the drug which makes it more accessible and user-friendly in the event of a seizure. Many studies have indicated quick cessation of seizures with Nayzilam compared to rectal diazepam, which has been the standard of care treatment. Nayzilam has been proven to be safe and effective for acute seizures in children, deeming it a revolutionary alternative …

Phenothiazines And Their Evolving Roles In Clinical Practice: A Narrative Review., Amber N. Edinoff, Grace Armistead, Christina A. Rosa, Alexandra Anderson, Ronan Patil, Elyse M. Cornett, Kevin S. Murnane, Adam M. Kaye, Alan David Kaye

School of Pharmacy Faculty Articles

Phenothiazines, a diverse class of drugs, can be used to treat multiple mental health and physical conditions. Phenothiazines have been used for decades to treat mental illnesses, including schizophrenia, mania in bipolar disorder, and psychosis. Additionally, these drugs offer relief for physical illnesses, including migraines, hiccups, nausea, and vomiting in both adults and children. Further research is needed to prove the efficacy of phenothiazines in treating physical symptoms. Phenothiazines are dopaminergic antagonists that inhibit D2 receptors with varying potency. High potency phenothiazines such as perphenazine are used to treat various psychiatric conditions such as the positive symptoms of schizophrenia, the …

Aduhelm, A Novel Anti-Amyloid Monoclonal Antibody, For The Treatment Of Alzheimer's Disease: A Comprehensive Review., Hannah W. Haddad, Garett W. Malone, Nicholas J. Comardelle, Arielle E. Degueure, Salomon Poliwoda, Rachel J. Kaye, Kevin S. Murnane, Adam M. Kaye, Alan David Kaye

School of Pharmacy Faculty Articles

Alzheimer's disease (AD) is the most common form of dementia affecting millions of individuals, including family members who often take on the role of caregivers. This debilitating disease reportedly consumes 8% of the total United States healthcare expenditure, with medical and nursing outlays accounting for an estimated $290 billion. Cholinesterase inhibitors and N-methyl-D-aspartate receptor antagonists have historically been the most widely used pharmacologic therapies for patients with AD; however, these drugs are not curative. The present investigation describes the epidemiology, pathophysiology, risk factors, presentation, and current treatment of AD followed by the role of the novel monoclonal antibody, Adulhelm, in …

Rimegepant For The Treatment Of Migraine., Amnon A. Berger, Ariel Winnick, Austin H. Carroll, Alexandra Welschmeyer, Nathan Li, Marc Colon, Antonella Paladini, Giovanni F. Ramírez, Jamal Hasoon, Elyse M. Cornett, Jaehong Song, Giustino Varrassi, Adam M. Kaye, Alan David Kaye, Latha Ganti

School of Pharmacy Faculty Articles

Migraine is a common form of primary headache, affecting up to 1 in every 6 Americans. The pathophysiology is an intricate interplay of genetic factors and environmental influence and is still being elucidated in ongoing studies. The trigeminovascular system is now known to have a significant role in the initiation of migraines, including the release of pain mediators such as CGRP and substance P. Traditional treatment of migraine is usually divided into acute and preventive treatment. Acute therapy includes non-specific therapy, such as NSAIDs and other analgesics, which may provide relief in mild to moderate migraines. 5-HT1 agonists may provide …

Reliability Of The Gymsafe Movement Screen To Predict Health And Biomechanical Faults In Female Gymnasts, Jennifer Kinder, Alyssa Herrera-Set, Jessica Wickizer, Claire Mauriel, Rachel Spivak, Joy Kuo, Todd E. Davenport

School of Pharmacy Faculty Articles

Background: Women’s gymnastics ranks second highest in collegiate sports for injuries. The gymSAFE Movement Screen (GMS) is the first screening application to identify areas associated with mechanisms of injury in gymnastics. Purpose: Investigate reliability of GMS scores between two physical therapists who varied in experience with gymnastics. Methods: 25 female gymnasts, between 5-16 years of age, were screened by two physical therapists. Percent agreement and intraclass correlation coefficients (ICCs) of scores were analyzed. Findings: ICC for total scores was .71 (95% CI (p<.002) for the first measurement and 0.51 (p <.043) for the second. Percent agreement fundamental gymnastic movements items ranged from 42.4% to 77.6%, and 84.6% to 92.3% for the strength and flexibility items. Clinical Relevance: A universal screen can assist in interdisciplinary care for female gymnasts. Conclusions: Overall, the physical therapists were strongly comparable especially in areas of strength and flexibility. Training for concordance appears necessary for fundamental gymnastics movement subscale because agreement was more variable.

Effects Of Tommy John Surgery, Draft Order, And Monetary Factors On The Value Of Pitchers In Major League Baseball, Jonathan P. Wong

University of the Pacific Theses and Dissertations

The purpose of this thesis is to determine what effects draft order, monetary earnings, and Tommy John Surgery (TJS) have on the perceived value of a pitcher in Major League Baseball (MLB). For the context of this thesis, value will be defined as a player's ability to contribute to their team's wins in a positive manner. TJS has become synonymous with MLB and baseball as a sport, and many are either skeptical of its effects or over-assuming of its benefits. The three aforementioned areas of concerns were used to structure the thesis, as each dependent outcome is analyzed in a …

Generational Differences In Nursing Turnover, Adam Bennett

Walden Dissertations and Doctoral Studies

Nursing is currently the largest job category in U.S. health care requiring proper recruitment and retention of nurses. As the current generation of nurses ages out of the workforce due to retirement, new nurses will need to cover the gaps in the workforce. The purpose of this quantitative correlational study was to examine the relationship between voluntary turnover, involuntary turnover, and career change among nurses who were born between 1980 and 1995 (Millennials) and those born between 1965 and 1979 (Generation X). The theoretical framework was Mannheim’s theory of generations. Secondary data were collected from exit interviews with 811 respondents …

Factors That Determine Utilization Of The Canadian School-Based Human Papilloma Virus Vaccine Programs, Diane Gloria Brown

Walden Dissertations and Doctoral Studies

Human Papilloma Virus (HPV) is the most common sexually transmitted infection in the world and is the known causative agent of many HPV-associated cancers in both males and females. HPV vaccination rates in Canada are significantly lower than other developed countries and this finding is poorly understood as Canadian adolescents have access to free-of-charge HPV vaccines through school-based vaccination programs. This quantitative descriptive study used an online survey to collect data from 992 eligible respondents. This study identified predisposing, enabling, and need factors characterized by the Andersen behavioral model of health services use which facilitate or impede the use of …

Secondary Data Analysis Of The Association Of Screen Time With Selected Health Behaviors, Kellany Cadogan Noland

Walden Dissertations and Doctoral Studies

The noticeable disparity in youth access of preventive healthcare and youth’s tendency towards excessive screen time have been linked to poor health outcomes. This issue prompted the current study, which had three core purposes: to identify associations between screen time and selected health behaviors, to identify target sociocultural and personal determinants of youth health, and to provide evidence to prompt innovation in promoting youth health via screen-based strategies. The social cognitive theory provided a context for triadic reciprocity between youth personal factors, environmental factors, and behaviors. A quantitative secondary analysis was completed using SPSS-27 to identify whether there was an …

Nurses' Experiences Caring For Patients With Opioid Use Disorder, Pamella Maureen Campbell

Walden Dissertations and Doctoral Studies

Over the past 2 decades, opioid use in the United States has taken thousands of lives, reached the level of epidemic in 2017, and has been an area of study among scholars. The problem is health care professionals, including nurses, lack training on how to care for people with opioid use disorder (OUD). Nurses are at the frontline of patient care and understanding the nurses’ experiences in the care of patients with OUD may help to improve the patients’ quality of care. The purpose of this qualitative descriptive study was to develop an understanding of the experiences of nurses with …

Fall Clinical Practical Guideline In A Psychiatric Hospital, Wendy Carroll Smith

Walden Dissertations and Doctoral Studies

Psychiatric hospitals are a unique environment and therefore pose unique challenges in preventing falls. Current evidence suggests that multidisciplinary committees to update clinical practice guidelines (CPG) will reduce falls and improve patient care in the acute inpatient psychiatric setting. The purpose of this study was to examine current evidence and develop new CPG with a goal to decrease falls in an inpatient psychiatric hospital. The Iowa model collaborative was used as a framework to develop the CPG to promote quality care and serve as an implementation model that supports the training of evidence-based practice. The methodology, design, and data analysis …

Why The Recognition Of Sentience Is So Important For Animal Welfare, Mark Jones

Animal Sentience

Rowan et al. (2022) provide a useful summary of the history and development of the philosophical, public, and legal recognition of animal sentience and its importance in improving the welfare of animals. Here I argue for the incorporation of the precautionary principle in sentience recognition, and the wider significance of sentience recognition to the current climate, biodiversity and human health crises.

Psychological Predictors Of Advanced Cancer Patients' Preferences For Return Of Results From Comprehensive Tumor Genomic Profiling, Bettina Meiser, Phyllis Butow, Grace Davies, Christine Napier, Timothy Schlub, Nicci Bartley, Ilona Juraskova, Mandy Ballinger, David M. Thomas, Kathy Tucker, David Goldstein, Barbara Biesecker, Megan Best

IES Papers and Journal Articles

This study assessed the psychological predictors of preferences for return of comprehensive tumor genomic profiling (CTGP) results in patients with advanced cancers, enrolled in the Molecular Screening and Therapeutics Program. Patients completed a questionnaire prior to undergoing CTGP. Of the 1434 who completed a questionnaire, 96% would like to receive results that can guide treatment for their cancer, and preference for receiving this type of result was associated with lower tolerance of uncertainty. Sixty-four percent would like to receive results that cannot guide treatment, and lower tolerance of uncertainty, self-efficacy, and perceived importance were associated with this preference. Fifty-nine …

The Impact Of Covid-19 On Cancer Patients, Their Carers And Oncology Health Professionals: A Qualitative Study, P Butow, P E. Havard, Z Butt, I Juraskova, H Sharpe, H Dhillon, L Beatty, P Beale, M Cigolini, B Kelly, R J. Chan, L Kirsten, Megan Best, J Shaw

IES Papers and Journal Articles

Objective: Cancer patients, carers and oncology health professionals have been impacted by the COVID-19 pandemic in many ways, but their experiences and psychosocial responses to the pandemic are still being explored. This study aimed to document the experience of Australians living with cancer, family carers, and Oncology health professionals (HPs) when COVID-19 first emerged.

Methods: In this qualitative study, participants (cancer patients currently receiving treatment, family carers and HPs) completed a semi-structured interview exploring their experiences of COVID-19 and the impact it had on cancer care. Participants also completed the Hospital Anxiety and Depression Scale (patients) and the Depression, Anxiety …

Fortitude, Spiritual Fortitude, And The Cancer Care Continuum In African American Breast Cancer Survivors, Karen Y. Boone

Walden Dissertations and Doctoral Studies

African American breast cancer survivors (AABCS) struggle with physical, emotional, psychological, spiritual, and financial challenges. Navigating these challenges can require the use of inner resources such as fortitude and spiritual fortitude. Using Folkman and Lazarus’ transactional model of stress and coping as the theoretical framework, the purpose of this study was to examine fortitude and spiritual fortitude as coping responses by African American women living with breast cancer and whether fortitude and spiritual fortitude were associated with phases of the cancer care continuum. A quantitative nonexperimental cross-sectional design was used for primary data collection that involved using Pretorius’ Fortitude Questionnaire …

The Impact Of Electronic Health Records Meaningful Use On Patient Safety And Satisfaction, Paulette Brown

Walden Dissertations and Doctoral Studies

AbstractThe widespread adoption of electronic health records (EHRs) is encouraged because of their potential to improve the quality of care provided. It was unknown to what extent the meaningful use of EHRs would impact patient safety and satisfaction in general and specialty hospitals. The researcher’s purpose for this quantitative correlational research was to examine the impact of meaningful EHR use of EHRs on patient safety and satisfaction outcomes in general and specialty hospitals in Philadelphia (PA). The constructs of the institutional theory guided the study. The hypotheses that guided the study included (a) Meaningful EHR use positively influences patient satisfaction …

The Relationship Between First Case On-Time Starts, Turnover Times, And Operating Room Productivity, Rhafia Bucoy

Walden Dissertations and Doctoral Studies

Operating room (OR) managers struggle to manage day-to-day surgical operations while meeting and exceeding organizational productivity amid the COVID-19 pandemic. The deferral of surgeries contributes to millions of backlogs of surgical case volume and unintended negative consequences. Grounded in the proposition that first-case on-time starts (FCOTS) and turnover time (TOT) are correlates of OR productivity, the purpose of this quantitative correlational study was to examine the relationship between FCOTS, TOT, and OR productivity. Archival data from 136 electronic surgical records were collected from two free-standing ambulatory surgery centers and analyzed using multiple regression. The results of the one-service, eye-specialized, ambulatory …

Working Mothers’ Lived Experiences Of Maintaining An Exercise Practice During A Pandemic, Sabrina Marie Cali

Walden Dissertations and Doctoral Studies

Working mothers have been associated with low levels of exercise during the COVID-19 pandemic. This population faces many challenges and obstacles to exercise as they manage a household and work; this lack of exercise could leave their health at risk. Researchers have not yet considered working mothers’ lived experiences with exercise during a pandemic. Existing research on working mothers indicates there are barriers to exercise for this population, but more information on what allows these mothers to sustain exercise is needed. This qualitative narrative study was conducted to explore the lived experiences of working mothers who maintained an exercise practice …

Obesity's Impact Among Asian Americans In Southern California, Alyssa Mae Sunga Carlos

Walden Dissertations and Doctoral Studies

Obesity continues to be an important public health issue in the United States, especially among minority populations. However, one minority group experiences the lowest obesity rate: Asian Americans. As a result, there is not much research available involving the impact of obesity and weight gain among this population. The purpose of this basic qualitative exploratory study was to improve the understanding of obesity’s impact on the Asian American population, specifically in Southern California, whose goals were to lose weight and become more informed about obesity’s impact on health. The study consisted of three main research questions. Twenty-five participants were interviewed …

Nutrition And Physical Exercise Prevention Strategies To Reduce Obesity During The Covid-19 Pandemic, Carmesha Vajill Carter

Walden Dissertations and Doctoral Studies

Obesity has reached an epidemic level of 75 million obese adults and 15 million obese children in the United States. The research problem addressed in this study is the lack of information on how obese people manage their weight-loss strategies to prevent or reduce obesity during shut-in place restrictions for the COVID-19 Pandemic. This study included the Prochaska and DiClemente Trans-Theoretical Model of Behavioral Change and the Stage of Change Theory. The phenomenon approach using phenomenology described participants' lived experiences of being obese. The researcher completed data collection and evaluation among sixteen participants using email questionnaires to analyze participant's responses …

The Role Of Self-Efficacy Against Workplace Stress, The Intent To Leave, And Burnout In Nursing, Alexis Collier

Walden Dissertations and Doctoral Studies

Healthcare administrators must sustain the nursing workforce by minimizing workplace stress, the intent to leave, and burnout while maintaining a safe, accessible, high-quality, patient-centered care environment. This quantitative study examined the relationship between the independent variable of self-efficacy and the dependent variables of nurse burnout, workplace stress, and the intent to leave. The theory that grounded this study was the theory of self-efficacy. The research questions were formatted to determine the correlation between the self-efficacy levels of nurses and burnout, workplace stress, and the intent to leave. A quantitative, nonexperimental, cross-sectional (analytical) design addressed the research questions. The secondary data …

Staff Nurse Education To Improve Adherence To Hypertension Management, Veronica Ositadinma Dike

Walden Dissertations and Doctoral Studies

AbstractAdherence to hypertension management medication(s) and lifestyle modification improve outcomes for patients diagnosed with hypertension. In this project, an educational program was developed to reduce the knowledge gap among staff nurses regarding addressing patients’ nonadherence to hypertension management in an outpatient clinic in the southern United States. Guided by andragogy and the health belief model, the staff nurse educational program was developed from evidence-based clinical practice guidelines and best practices from literature to evaluate the impact of education on improving staff nurses’ knowledge related to addressing patients’ nonadherence to hypertension management with the goal of reducing the associated medical costs, …

Adolescent Cyberbullying Program Experiences Of White Rural Males, Lonnie Lynn Erskine

Walden Dissertations and Doctoral Studies

Technology has become a gateway to use aggression against others. Cyberbullying is an ongoing problem, often causing severe mental, physical, and emotional issues. The purpose of this generic qualitative study was to explore the experiences of White rural males between the ages of 18–30 who experienced cyberbullying prevention and intervention programs when they were between the ages of 15–18. The research question directly addressed this purpose. Prevention and intervention can be powerful if utilized correctly, providing adolescents with assistance, safety, and assurance to cope with cyberbullying effectively. Vygotsky’s social development theory guided this study. Eight individuals participated in semistructured interviews. …

The Relationship Of Servant Leadership And Psychological Safety On Team Performance In Healthcare, Amy Lynn Palmiero

Walden Dissertations and Doctoral Studies

AbstractTeamwork in healthcare is a dynamic and complex process where interdisciplinary individuals must come together to deliver high-quality patient care. Despite significant overall improvements in healthcare delivery, process failures and communication breakdowns continue to be problematic leading to inefficiencies within the healthcare system resulting in higher costs, and in some instances, preventable patient harm. An examination of the relationship between leadership, psychological safety, and team performance provides valuable insight on the importance of the role leadership plays in shaping psychologically safe environments and enhancing team performance. Using servant leadership theory as the framework for this study, a quantitative correlational approach …

Relationship Between Incentive Program Costs, Incentive Payments, And Profitability, Claire Claire Turner

Walden Dissertations and Doctoral Studies

The lack of profitability among primary care businesses can have harmful impacts on business operations. Primary care businesses owners must remain profitable to remain in business and provide quality health care to patients. Grounded in Freeman’s stakeholder theory, the purpose of this quantitative correlational study was to examine the relationship between incentive program costs, incentive payments, and profitability. Data were collected from 73 primary care physician business owners in the Inland Empire region of southern California. The multiple linear regression analysis results indicated the model was able to significantly predict profitability, F(2,70) = 1343.6, p <.001, R2 = .975. Incentive payments (t = 51.837, p < .001,  = .928) was the only statistically significant predictor. Key recommendations include educating primary care physicians on the potential financial benefits of full participation in the commercial line of business pay-for-performance incentive programs and creating a campaign to bring in patients for wellness visits. The implications for positive social change include the potential for an additional revenue stream for primary care physician business owners, which could support more clinics, increasing patient access. Patients having better access to healthcare could positively affect the health and wellness of individuals in local communities.

Pharmacists’ Responses To Medication Management Following Disasters, Rellamichelle W. Tyree

Walden Dissertations and Doctoral Studies

Disasters, both natural and human made, can cause emerging health threats in the United States and the Caribbean. The disasters that pharmacists experienced and reported for this study included hurricanes, snowstorms, ice storms, flooding, and a pandemic. The purpose of this research was to investigate the challenges and outcomes associated with pharmacists’ medication management practices during and following disasters. This generic qualitative study focused on pharmacists’ experiences and their responses to disaster planning and medication management activities. The ecological model of disaster management was the conceptual framework used to investigate the pharmacists and their responses and actions used to address …

Parents' And Caregivers' Attitudes About Child Passenger Safety, Latoya Wider

Walden Dissertations and Doctoral Studies

Motor vehicle crashes are a leading cause of childhood injury and death in the United States. Many car seats are installed incorrectly, and many children under the age of 6 are seriously injured or killed in a motor vehicle crash. The purpose of this study was to examine the relationship between age of child, age of parent/caregiver, attitudes, and behaviors of child passenger safety among parents and caregivers in South Carolina. The influence of age and attitude on consistent car seat use was also examined. The study was based on the theory of planned behavior. A survey design featuring questions …

Improving Nurse Retention: Experiences Of 1st-Year Nurses With A Residency Program, James Uchenna Akwarandu

Walden Dissertations and Doctoral Studies

Nurse residency programs have been identified as a strategy for supporting new nurses as they transition to clinical and professional practice but the impact has not been adequately explored. Exploring the transition experiences of new nurses in residency programs supports healthcare administrators’ understanding and may provide enhancements. Guided by Bridges’s transition theory, this research gave nurses who had recently graduated from a residency program, the opportunity to express their unique transition experience. Using snowball sampling and semi structured telephone interviews, participants responded to the guiding question of how new nurses describe their transition experiences in a nurse residency program. Interviews …