Medicine and Health Sciences Commons^™

Statistical Analysis Plan For The Stepped-Wedge Clinical Trial Healing Right Way - Enhancing Rehabilitation Services For Aboriginal Australians After Brain Injury, Elizabeth Armstrong, Tapan Rai, Deborah Hersh, Sandra Thompson, Juli Coffin, Natalie Ciccone, Leon Flicker, Dominique Cadilhac, Erin Godecke, Deborah Woods, Colleen Hayward, Graeme J. Hankey, Meaghan Mcallister, Judith Katzenellenbogen

Research outputs 2022 to 2026

Background: Aboriginal Australians are known to suffer high levels of acquired brain injury (stroke and traumatic brain injury) yet experience significant barriers in accessing rehabilitation services. The aim of the Healing Right Way trial is to evaluate a culturally secure intervention for Aboriginal people with newly acquired brain injury to improve their rehabilitation experience and quality of life. Following publication of the trial protocol, this paper outlines the statistical analysis plan prior to locking the database. Methods: The trial involves a stepped wedge design with four steps over 3 years. Participants were 108 adult Aboriginal Australians admitted to one of …

The Agreement Between A Portable Contact-Mat And Force-Plates During Bilateral Vertical Jumps, Stuart N. Guppy, Yosuke Kotani, Jason Lake, Christopher Latella, Jodie Cochrane Wilkie, Kristina Kendall, G. Gregory Haff

Research outputs 2022 to 2026

Force plates are commonly used when assessing vertical jumping performance but are not always affordable or practical tools for all testing situations. Twenty-four participants volunteered to take part in a study investigating the agreement between bilateral force plates and a new commercially available contact mat that records jump height, flight-time (FT), and FT of individual limbs during both countermovement (CMJ) and squat (SJ) jumps. Each participant performed six jumps of each type while standing on a contact mat placed upon a pair of in-ground force plates. When compared to the force plate via ordinary least products regression, the contact mat …

Tox And Detox: Are Teens' Smartphone Use And Non-Use Practices Fully Fungible?, Lelia Green, Debra Dudek, Lynne Cohen, Kjartan Ólafsson, Elisabeth Staksrud, Carmen Louise Jacques, Kelly Jaunzems

Research outputs 2022 to 2026

The public sphere includes a range of credible discourses asserting that a proportion of teenagers (“teens”) has an unhealthy dependence upon continuous connection with media devices, and especially smartphones. A review of media discourse (Jaunzems et al.) in Australia, and a critical review of public discourse in Australia and Belgium (Zaman et al.), reveal both positive and negative commentary around screentime. Despite the “emotionally laden, opposing views” expressed in the media, there appears to be a groundswell of concern around young people’s dependence upon digital devices (Zaman et al. 120). Concerns about ‘addiction’ to and dependency on digital media first …

Effectiveness Of Universal Newborn Hearing Screening: A Systematic Review And Meta-Analysis, Karen Edmond, Shelly Chadha, Cynthia Hunnicutt, Natalie Strobel, Vinaya Manchaiah, Christine Yoshinaga-Itano, Universal Newborn Hearing Screening (Unhs) Review Group

Research outputs 2022 to 2026

Background:

Permanent bilateral hearing loss (PBHL) is a serious condition in newborns, with a prevalence of at least one per 1000 live births. However, there has been no recent systematic review and meta-analysis of the effectiveness of universal newborn hearing screening programs (UNHS).

Methods:

We registered our study protocol on PROSPERO CRD42020175451. Primary outcomes were any identification of PBHL (ie, PBHL diagnosed at any time), age of identification of PBHL, and neurodevelopment. Two reviewers searched standard databases to March 2022 and extracted data. We used fixed and random effects meta-analysis to pool data and graded the certainty of evidence using …

Epidemiology Of ∆8thc-Related Carcinogenesis In Usa: A Panel Regression And Causal Inferential Study, Albert Stuart Reece, Gary Kenneth Hulse

Research outputs 2022 to 2026

The use of ∆8THC is increasing at present across the USA in association with widespread cannabis legalization and the common notion that it is “legal weed”. As genotoxic actions have been described for many cannabinoids, we studied the cancer epidemiology of ∆8THC. Data on 34 cancer types was from the Centers for Disease Control Atlanta Georgia, substance abuse data from the Substance Abuse and Mental Health Services Administration, ethnicity and income data from the U.S. Census Bureau, and cannabinoid concentration data from the Drug Enforcement Agency, were combined and processed in R. Eight cancers (corpus uteri, liver, gastric cardia, breast …

What Are The Benefits And Challenges Of Mentoring In Midwifery? An Integrative Review, Krystyl Wissemann, Dianne Bloxsome, Annemarie De Leo, Sara Bayes

Research outputs 2022 to 2026

Aim: The aim of this review was to synthesize best available evidence on mentoring programmes for midwives who have worked within the clinical setting for more than 1 year. Background: Lack of job satisfaction, stress, burnout and limited managerial support contributes to midwifery workforce attrition and the ongoing global shortage of midwives. Mentoring may be one way to improve staff retention, leading to positive clinical and organizational outcomes. Design: A five-step integrative review approach, based on a series of articles published by the Joanna Briggs Institute for conducting systematic reviews, was used to develop a search strategy, selection criteria, method …

Urinary Metabotype Of Severe Asthma Evidences Decreased Carnitine Metabolism Independent Of Oral Corticosteroid Treatment In The U-Biopred Study, Stacey N. Reinke, Shama Naz, Romanas Chaleckis, Hector Gallart-Ayala, Johan Kolmert, Nazanin Z. Kermani, Angelica Tiotiu, David I. Broadhurst, Anders Lundqvist, Henric Olsson, Marika Strom, Asa M. Wheelock, Cristina Gómez, Magnus Ericsson, Ana R. Sousa, John H. Riley, Stewart Bates, James Scholfield, Matthew Loza, Frederic Baribaud, Per S. Bakke, Massimo Caruso, Pascal Chanez, Stephen J. Fowler, Thomas Geiser, Peter Howarth, Ildiko Horvath, Norbert Krug, Paolo Montuschi, Annelie Behndig, Florian Singer, Jacek Musial, Dominick E. Shaw, Barbro Dahlén, Sile Hu, Jessica Lasky-Su, Peter J. Sterk, Kian Fan Chung, Ratko Djukanovic, Sven Erik Dahlé, Ian M. Adcock, Craig E. Wheelock

Research outputs 2014 to 2021

Introduction: Asthma is a heterogeneous disease with poorly defined phenotypes. Severe asthmatics often receive multiple treatments including oral corticosteroids (OCS). Treatment may modify the observed metabotype, rendering it challenging to investigate underlying disease mechanisms. Here, we aimed to identify dysregulated metabolic processes in relation to asthma severity and medication. Methods: Baseline urine was collected prospectively from healthy participants (n=100), mild-to-moderate asthmatics (n=87) and severe asthmatics (n=418) in the cross-sectional U-BIOPRED cohort; 12–18-month longitudinal samples were collected from severe asthmatics (n=305). Metabolomics data were acquired using high-resolution mass spectrometry and analysed using univariate and multivariate methods. Results: Ninety metabolites were identified, …

Independent And Interactive Associations Of Dietary Nitrate And Salt Intake With Blood Pressure And Cognitive Function: A Cross-Sectional Analysis In The Inchianti Study, Andrea M. Mcgrattan, Blossom C. M. Stephan, Oliver M. Shannon, Mohsen Mazidi, Mark Gilchrist, Miranda Smallwood, Paul Winyard, Nicholas Mcmahon, Lauren C. Blekkenhorst, Devi Mohan, Stefania Bandinelli, Louise Robinson, Luigi Ferrucci, Mario Siervo

Research outputs 2014 to 2021

Blood pressure (BP) control is a key target for interventions to reduce cognitive decline. This cross-sectional study explored associations between objective (24-hour urine excretion) and subjective (food frequency questionnaire [FFQ]) measures of dietary sodium and nitrate intakes with cognitive function and resting BP in the InCHIANTI cohort. Baseline data from 989 participants aged >50 years were included. In fully adjusted models, participants with concurrent high nitrate and low sodium (Odds Ratio (OR)=0.49, 95%CI 0.32–0.76, p = 0.001) and high nitrate and high sodium (OR = 0.49, 95%CI 0.32–0.77, p = 0.002) 24-hour urinary concentrations had lower odds of high BP …

The Use Of Complementary Medicine During Childbearing Years: A Multi-Country Study Of Women From The Middle East, Diana Arabiat, Lisa Whitehead, Samia Gaballah, Nazi Nejat, Ebtehal Galal, Eman Abu Sabah, Nazek Smadi, Inas Saadeh, Randa Khlaif

Research outputs 2014 to 2021

The prevalence of self-prescribed complementary medicine (CM) use is an area of concern across the Middle East. We conducted a descriptive qualitative study to describe women’s use of CM during their childbearing years in Egypt, Jordan, Saudi Arabia and Iran. The study conducted using face to face audio-recorded interviews with 70 participants. Our findings showed that women used several herbal plants to ease pain and discomfort during menstruation and/or during pregnancy and in postpartum care. Acupuncture, meditation, and massage were less likely to be used by women. The impact of CM was often described in relation to perceived usefulness and …

Myokine Expression And Tumor-Suppressive Effect Of Serum Following 12 Weeks Of Exercise In Prostate Cancer Patients On Adt, Jin-Soo Kim, Rebekah Louise Wilson, Dennis Taaffe, Daniel A. Galvao, Elin S. Gray, Robert Newton

Research outputs 2014 to 2021

Purpose:

Although several mechanisms have been proposed for the tumor-suppressive effect of exercise, little attention has been given to myokines, even though skeletal muscle is heavily recruited during exercise resulting in myokine surges. We measured resting serum myokine levels before and after an exercise-based intervention and the effect of this serum on prostate cancer cell growth.

Methods:

Ten prostate cancer patients undertaking androgen deprivation therapy (age, 73.3 ± 5.6 yr) undertook a 12-wk exercise-based intervention including supervised resistance training, self-directed aerobic exercise, and protein supplementation. Body composition was assessed by dual-energy x-ray absorptiometry and muscle strength by the one-repetition maximum …

The Association Between An Energy-Adjusted Dietary Inflammatory Index And Inflammation In Rural And Urban Black South Africans, Maylene Ferreira, H. Toinét Cronjé, Tertia Van Zyl, Nicola P. Bondonno, Marlien Pieters

Research outputs 2014 to 2021

Objective:

To quantify the inflammatory potential of the diet of rural and urban Black South Africans using an adapted energy-adjusted dietary inflammatory index (AE-DII) and to investigate its relationship with inflammatory and cardio-metabolic disease risk markers. Dietary inflammatory potential has not been investigated in African populations.

Design:

Cross-sectional investigation.

Setting:

Rural and urban sites in the North West province of South Africa.

Participants:

1,885 randomly selected, apparently healthy Black South Africans older than 30 years.

Results:

AE-DII scores ranged from -3.71 to +5.08 with a mean of +0.37. AE-DII scores were significantly higher in men (0.47±1.19) than in women (0.32±1.29), …

Does Race Have An Influence On The Athletic Trainer-Coach Relationship, Cayce M. Sloan

College of Graduate Studies: Theses & Dissertations

Introduction: Interpersonal relationships are the most frequent types of relationships individuals maintain on a daily basis. Rapport provides the foundation necessary to build positive interpersonal relationships, specifically, collegial relationships such as the relationship between the athletic trainer and coach. However, facilitators and barriers exist that may hinder relationships. Specifically, race appears to influence relationships, but to date, it appears race has not been examined in the athletic trainer-coach relationship. Therefore, the purpose of this study was to examine the facilitators and barriers to building rapport in race-discordant athletic trainer-coach relationships and to examine the role race plays within the athletic …

The Relationships Between Sleep Quality, Health-Related Quality Of Life, And Injury In High School Student Athletes, Karleigh Kirsch

College of Graduate Studies: Theses & Dissertations

Various physiological and lifestyle factors make shorter sleep durations more prevalent in young people, leaving them at risk of sleep deprivation. In addition to overall poorer health outcomes and decreases in well-being, lack of sleep has known effects on performance, neurocognitive functioning, and recovery from exercise. This creates a greater potential for sport-related injury to occur. The purpose of this study was to investigate the relationships between sleep quality, health-related quality of life, and injury in high school student athletes. The sample consisted of 100 high school athletes (M age = 15.86, SD = 1.25 years). Participants completed a …

Barriers To Musculoskeletal Injury Reporting In High School Athletes: A Qualitative Study, Mikayla Talak

College of Graduate Studies: Theses & Dissertations

INTRODUCTION: There are a substantial amount of sport related injuries recorded at the high school age and it has been recorded as a public health concern in a vast amount of health literature. Although participating in sports has a risk of injury associated with it, it is common for high school athletes to underreport injuries. But there is no known literature on injury reporting behaviors of musculoskeletal injuries in the high school athletic population. Therefore, the purpose of this study is to explore the barriers and facilitators to musculoskeletal injury reporting and towards playing injured in athletes that attend a …

Summary Of Aboriginal And Torres Strait Islander Health Status - Selected Topics 2021, Australian Indigenous Healthinfonet

Research outputs 2022 to 2026

...The HealthInfoNet has prepared this Summary as part of our contribution to support those who work in the Aboriginal and Torres Strait Islander health sector. Key health topics are summarised in plain language and an infographic style to enable readers to absorb data easily and quickly...

The Enantiomer Of Allopregnanolone Prevents Pressure-Mediated Retinal Degeneration Via Autophagy, Makoto Ishikawa, Toru Nakazawa, Hiroshi Kunikata, Kota Sato, Takeshi Yoshitomi, Kathiresan Krishnan, Douglas F Covey, Charles F Zorumski, Yukitoshi Izumi

2020-Current year OA Pubs

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A Case For Menstrual Health Disparities As A Part Of Public Health Discourse, Mykala Jackson, Sandhya Lohani, Joanne Chopak-Foss, Tilicia Mayo-Gamble

Eagles Talking About the Public’s Health

No abstract provided.

Telemedicine Use In Rural America: Building On Current Momentum, Jennifer E. Akpo, Aishat Adewoye, Samuel T. Opoku

Eagles Talking About the Public’s Health

No abstract provided.

Policy Implication: Improving Perinatal Mental Health Care In Georgia, Tobi F. Oloyede, Joanne Chopak-Foss

Eagles Talking About the Public’s Health

No abstract provided.

Period Equity Movement: Addressing Learning Loss, Equity, Safety And The Environment, Gabi Wiggill, Gemma C. Skuraton, Megan Mercer, Katie M. Mercer

Eagles Talking About the Public’s Health

No abstract provided.

Asian Long-Horned Tick Haemaphysalis Longicornis: What Happens In Asia Does Not Stay In Asia, Shobhan Das, Marina Eremeeva

Eagles Talking About the Public’s Health

No abstract provided.

Assessing The Effectiveness Of An Egg Intervention In The Nutritional And Food Security Status Of Infants And Toddlers From Rural Honduras, Aishat Adewoye, Mario Keko, Luke Roberson, Dziyana Nazaruk, Gisela Ramos, Laura Manship, Haresh Rochani Dr., Asli Aslan, Ana M. Palacios

Eagles Talking About the Public’s Health

No abstract provided.

Protocol For The Perioperative Outcome Risk Assessment With Computer Learning Enhancement (Periop Oracle) Randomized Study, Bradley Fritz, Christopher King, Yixin Chen, Alex Kronzer, Joanna Abraham, Arbi Ben Abdallah, Thomas Kannampallil, Thaddeus Budelier, Arianna Montes De Oca, Sherry Mckinnon, Bethany Tellor Pennington, Troy Wildes, Michael Avidan

2020-Current year OA Pubs

No abstract provided.

Correlates Of Risky Sexual Behaviors Among African American Females In Juvenile Detention Centers, Eghosa E. Asemota

College of Graduate Studies: Theses & Dissertations

Introduction: In comparison to other demographics, research shows that African American female adolescents are over-represented in the United States Juvenile Justice System. Studies in this vulnerable population demonstrate higher rates of engagement in unsafe sex, and its attendant negative consequences of HIV infections, sexually transmitted diseases, and mistimed pregnancies. There is a paucity of studies that have specifically examined risky sexual behaviors amongst African American females in Juvenile Detention Centers. Objective: The aim of this study is to assess the relationship between the individual, family, peer, and societal factors, and engagement in risky sex among Black female detainees in Juvenile …

The Relationship Between Physical Mobility And Firefighter Occupational Task Performance, Shelby Harbison

College of Graduate Studies: Theses & Dissertations

BACKGROUND: Firefighters work in a dangerous profession with high injury rates. Mobility dysfunction in firefighters may impact performance and contribute to injury. The Functional Movement Screen (FMS) is commonly used to evaluate individuals for mobility dysfunction and compensatory movements. PURPOSE: Identify if mobility is related to firefighters’ occupational task performance. METHODS: This was a retrospective study assessing 29 career firefighters using FMS and occupational performance task scores. Statistical analyses consisted of a multiple linear regression assessing predictors on the occupational task performance and 21 point-biserial correlations ran to assess the relationship between each individual predictor and occupational task performance. RESULTS: …

Generalization Of Net Benefit Of Diagnostic Tests Into Multi-Stage Clinical Conditions: A Collapsing Approach, Ferdous Ahmed

College of Graduate Studies: Theses & Dissertations

Evaluating diagnostic tests based on benefit-risk involves both the tests’ accuracy and the clinical implications of the diagnostic errors. Diagnostic tests are commonly classified into two stages: either positive or negative for a clinical condition (diseased or non-diseased). However, some diseases have more than two stages, such as Alzheimer’s. In diseases with more than two stages, the benefits and risks of the clinical consequences could differ from stage to stage. I could not find any investigations to account for the difference in benefits and risks of tests with more than two stages in the literature. The benefit to cost values …

Characteristics And Regions Of Hospital Locations And The Risk Of Postpartum Hemorrhage., Zahra Shahin

College of Graduate Studies: Theses & Dissertations

Background: Postpartum hemorrhage (PPH) is one of the contributing factors to maternal morbidity and mortality that in addition to maternal risk factors, may be related to other factors such as obstetric practice and clinical management of postpartum hemorrhage. Therefore, this study aimed to explore the association of postpartum hemorrhage with characteristics and regions of hospital locations across the United States, as the outcomes may create opportunities to improve policies and protocols regarding PPH management more effectively. Method: A retrospective study was performed using the 2018 National Inpatient Sample (NIS) database. Low-risk delivery hospitalizations involving the third stage of labor with …

Practices Of Vitamin D Supplementation Leading To Vitamin D Toxicity: Experience From A Low-Middle Income Country, Siraj Muneer, Imran Siddiqui, Hafsa Majid, Nawazish Zehra, Lena Jafri, Aysha Habib

Department of Pathology and Laboratory Medicine

Introduction: The trend of prescribing VD preparations for nonspecific body aches and self-medication has increased significantly. The importance of vitamin D toxicity (VDT) has been underestimated and under recognized. This study was done to determine the frequency toxicity (>150 ng/ml) in subjects for 25-hydroxyvitamin D (25OHD) and evaluate the vitamin D (VD) supplements used by these subjects.
Methodology: This descriptive cross-sectional study was conducted at the Section of Chemical Pathology, Aga Khan University Hospital Karachi from April 2020 to March 2021. Subjects with 25OHD toxicity were contacted and information related to history of calcium and VD supplementation were collected. …

D-Dimer Testing In Covid-19: From Basics To Clinical Application, Bushra Moiz

Department of Pathology and Laboratory Medicine

No abstract provided.

Prevalence And Risk Factors Of Preterm Birth Among Pregnant Women Admitted At The Labor Ward Of The Komfo Anokye Teaching Hospital, Ghana, Enoch Odame Anto, Wina Ivy Ofori Boadu, Stephen Opoku, Ebenzer Senu, Valentine Christian Kodzo Tsatsu Tamakloe, Augustine Tawiah, Frank Ankobea, Emmanuel Acheampong, Agartha Odame Anto, Michael Appiah, Yaw Amo Wiafe, Max Efui Annani-Akollor, Christian Obirikorang, Otchere Addai-Mensah

Research outputs 2022 to 2026

Preterm birth is a global epidemic and a leading cause of neonatal mortality in Sub-Saharan Africa. We evaluated the prevalence and risk factors of preterm birth among women attending the labor ward for delivery at a tertiary hospital in Ghana. This comparative cross-sectional study was conducted among a cohort of 209 pregnant women admitted to the labor ward of the Komfo Anokye Teaching Hospital (KATH). Pregnant women who delivered between 28 and 36 completed weeks of gestation were classified as preterm delivery whereas those who delivered after 37–42 completed weeks were described as term. Sociodemographic, clinical, and obstetric data were …