Medicine and Health Sciences Commons^™

Comparing Antigenaemia- And Microfilaraemia As Criteria For Stopping Decisions In Lymphatic Filariasis Elimination Programmes In Africa, Wilma A. Stolk, Luc E. Coffeng, Fatorma K. Bolay, Obiora A. Eneanya, Peter U. Fischer, T. Déirdre Hollingsworth, Benjamin G. Koudou, Aboulaye Méité, Edwin Michael, Joaquin M. Prada, Rocio M. Caja Rivera, Swarnali Sharma, Panayiota Touloupou, Gary J. Weil, Sake J. De Vlas

2020-Current year OA Pubs

BACKGROUND: Mass drug administration (MDA) is the main strategy towards lymphatic filariasis (LF) elimination. Progress is monitored by assessing microfilaraemia (Mf) or circulating filarial antigenaemia (CFA) prevalence, the latter being more practical for field surveys. The current criterion for stopping MDA requires <2% CFA prevalence in 6- to 7-year olds, but this criterion is not evidence-based. We used mathematical modelling to investigate the validity of different thresholds regarding testing method and age group for African MDA programmes using ivermectin plus albendazole.

METHODOLGY/PRINCIPAL FINDINGS: We verified that our model captures observed patterns in Mf and CFA prevalence during annual MDA, assuming that CFA tests are positive if at least one adult worm is present. We then assessed how well elimination can be predicted from CFA prevalence in 6-7-year-old children or from Mf or CFA prevalence in the 5+ or 15+ …

Ten Simple Rules And A Template For Creating Workflows-As-Applications, Michael J. Roach, N. Tessa Pierce-Ward, Radoslaw Suchecki, Vijini Mallawaarachchi, Bhavya Papudeshi, Scott A. Handley, C. Titus Brown, Nathan S. Watson-Haigh, Robert A. Edwards

2020-Current year OA Pubs

No abstract provided.

Whole-Genome And Long-Read Sequencing Identify A Novel Mechanism In Rfc1 Resulting In Canvas Syndrome, Katherine Abell King, Daniel J. Wegner, Robert C. Bucelli, Jessica Shapiro, Alexander J. Paul, Patricia I. Dickson, Jennifer A. Wambach, Undiagnosed Disease Network

2020-Current year OA Pubs

OBJECTIVES: Cerebellar ataxia with neuropathy and bilateral vestibular areflexia syndrome (CANVAS) results from biallelic intronic pentanucleotide repeats in

METHODS: We performed whole-genome sequencing (WGS) on peripheral blood DNA samples from the proband and his unaffected mother. We performed DNA long-read sequencing and synthesized complementary DNA from RNA using peripheral blood from the proband.

RESULTS: WGS confirmed the maternally inherited

DISCUSSION: We report an adult with CANVAS due to compound heterozygous pathogenic

Glycemia And Β-Cell Function Before And After Elexacaftor/Tezacaftor/Ivacaftor In Youth And Adults With Cystic Fibrosis, Christine L Chan, Andrea Granados, Amir Moheet, Sachinkumar Singh, Timothy Vigers, Ana Maria Arbeláez, Yaling Yi, Shanming Hu, Andrew W Norris, Katie Larson Ode

2020-Current year OA Pubs

BACKGROUND: Diabetes is prevalent among people with CF (PwCF) and associated with worse clinical outcomes. CFTR modulators are highly effective in improving the disease course of CF. However, the effects of elexacaftor/tezacaftor/ivacaftor (ETI) on glucose metabolism in PwCF are unclear.

METHODS: Twenty youth and adults with CF underwent frequently sampled oral glucose tolerance tests (fsOGTT) before and after ETI initiation. Glucose, insulin, and C-peptide were collected at 0, 10, 30, 60, 90, and 120 min after 1.75 g/kg (max 75 g) of dextrose. HbA1c and continuous glucose monitoring (CGM) were collected in a subset. Estimates of insulin secretion (C-peptide index), …

The Genetic Risk Factor Cel-Hyb1 Causes Proteotoxicity And Chronic Pancreatitis In Mice, Karianne Fjeld, Steven J Wilhelm, Jianguo Lin, Xunjun Xiao, Mark E Lowe, Et Al.

2020-Current year OA Pubs

BACKGROUND & AIMS: The CEL gene encodes the digestive enzyme carboxyl ester lipase. CEL-HYB1, a hybrid allele of CEL and its adjacent pseudogene CELP, is a genetic variant suggested to increase the risk of chronic pancreatitis (CP). Our aim was to develop a mouse model for CEL-HYB1 that enables studies of pancreatic disease mechanisms.

METHODS: We established a knock-in mouse strain where the variable number of tandem repeat (VNTR) region of the endogenous mouse Cel gene was substituted with the mutated VNTR of the human CEL-HYB1 allele. Heterozygous and homozygous Cel-HYB1 mice and littermate wildtype controls were characterized with respect …

The Clinical Landscape Of Cell-Free Dna Alterations In 1671 Patients With Advanced Biliary Tract Cancer, J E Berchuck, B Tan, Et Al.

2020-Current year OA Pubs

BACKGROUND: Targeted therapies have transformed clinical management of advanced biliary tract cancer (BTC). Cell-free DNA (cfDNA) analysis is an attractive approach for cancer genomic profiling that overcomes many limitations of traditional tissue-based analysis. We examined cfDNA as a tool to inform clinical management of patients with advanced BTC and generate novel insights into BTC tumor biology.

PATIENTS AND METHODS: We analyzed next-generation sequencing data of 2068 cfDNA samples from 1671 patients with advanced BTC generated with Guardant360. We carried out clinical annotation on a multi-institutional subset (n = 225) to assess intra-patient cfDNA-tumor concordance and the association of cfDNA variant …

A Novel, Likely Pathogenic Variant In Ubtf-Related Neurodegeneration With Brain Atrophy Is Associated With A Severe Divergent Neurodevelopmental Phenotype, Rory J Tinker, Tiffany Guess, David C Rinker, Jonathan H Sheehan, Daniel Lubarsky, Binu Porath, Mackenzie Mosera, Ping Mayo, Emily Solem, Laura A Lee, Asha Sharam, Jennifer Brault

2020-Current year OA Pubs

BACKGROUND: A de novo, pathogenic, missense variant in UBTF, c.628G>A p.Glu210Lys, has been described as the cause of an emerging neurodegenerative disorder, Childhood-Onset Neurodegeneration with Brain Atrophy (CONDBA). The p.Glu210Lys alteration yields a positively charged stretch of three lysine residues. Functional studies confirmed this change results in a stronger interaction with negatively charged DNA and gain-of-function activity when compared to the wild-type sequence. The CONDBA phenotype reported in association with p.Glu210Lys consists of normal early-neurodevelopment followed by progressive motor, cognitive, and behavioral regression in early-to-middle childhood.

METHODS AND RESULTS: The current proband presented at 9 months of age with …

Lifespan Benefits For The Combination Of Rapamycin Plus Acarbose And For Captopril In Genetically Heterogeneous Mice, Randy Strong, Kerry Kornfeld, Et Al.

2020-Current year OA Pubs

Mice bred in 2017 and entered into the C2017 cohort were tested for possible lifespan benefits of (R/S)-1,3-butanediol (BD), captopril (Capt), leucine (Leu), the Nrf2-activating botanical mixture PB125, sulindac, syringaresinol, or the combination of rapamycin and acarbose started at 9 or 16 months of age (RaAc9, RaAc16). In male mice, the combination of Rapa and Aca started at 9 months and led to a longer lifespan than in either of the two prior cohorts of mice treated with Rapa only, suggesting that this drug combination was more potent than either of its components used alone. In females, lifespan in mice …

Payment Profiles: Using Payment Transaction Data To Identify And Characterize Gamblers, Kasra Ghaharian

UNLV Theses, Dissertations, Professional Papers, and Capstones

Payment providers in the gambling industry facilitate transactions, allowing customers to transfer money to and from wagering accounts. Payments transaction data is information that is captured from these transactions, including, for example, the type, amount, time, and location. How this data may be used for gambling harm minimization and prevention has garnered significant interest, particularly due to accelerated payments modernization in the wake of the COVID-19 pandemic. With this study, I explored the utility of payments transaction data to categorize subgroups of gamblers in order to identify individuals who may be at-risk of harm. I benchmarked six cluster analysis methods …

Salesperson-Customer Dyads In The Casino Gaming Industry: How Sales Competencies And Relationship Lifecycles Influence Customer Satisfaction And Account Profitability, Alicia Lechtenberger

UNLV Theses, Dissertations, Professional Papers, and Capstones

Developing extraordinary relationships between sales personnel and customers is essential to corporate success. To meet the increasing demands of customers within the hospitality industry, corporations must ensure they pair customers with salespeople who are highly competent, possessing refined and adaptable skill sets that directly increase customer satisfaction and account profitability. Corporations spend billions of dollars annually on hiring and training salespeople; yet, salespeople often quit or miss their quota targets. Considering this industry-wide business problem, the purpose of this dissertation study was to determine how sales competencies influence customer satisfaction and account profitability while taking into consideration the duration of …

Automated Approach For The Enhancement Of Scaffolding Structure Monitoring With Strain Sensor Data, Sayan Sakhakarmi

UNLV Theses, Dissertations, Professional Papers, and Capstones

Construction researchers have made a significant effort to improve the safety of scaffolding structures, as a large proportion of workers are involved in construction activities requiring scaffolds. However, most past studies focused on design and planning aspects of scaffolds. While limited studies investigated scaffolding safety during construction, they are limited to simple cases only with limited failure modes and simple scaffolds. In response to this limitation, this study aims to develop an automated scaffold monitoring approach capable of monitoring large scaffolds. Accordingly, this study developed an automated scaffold safety monitoring framework that leverages sensor data collected from a scaffold, scaffold …

Covid-19 Vaccine Acceptance Behavior Among Hispanics/Latinxs In Nevada: A Theory-Based Analysis, Tara Marie Naoe Tacderan Wong Nerida

UNLV Theses, Dissertations, Professional Papers, and Capstones

The COVID-19 pandemic has impacted many lives around the world, leaving negative repercussions including health effects, economic downturns, and social and physical restrictions. The pandemic has also revealed many disproportionate health impacts on vulnerable populations, especially among the Hispanic and Latinx populations. The use of the three COVID-19 vaccines in the United States has presented a form of protection against additional negative impacts. However, hesitancy toward the COVID-19 vaccine has hindered its rapid uptake, preventing the country from reaching herd immunity and ultimately ending the pandemic. Current research is minimal in understanding the intentions of receiving the COVID-19 vaccine among …

Vitamin D Enhances Type I Ifn Signaling In Covid-19 Patients, Shirin Hafezi, Fatemeh Saheb Sharif-Askari, Narjes Saheb Sharif-Askari, Hawra Ali Hussain Alsayed, Habiba Alsafar, Fatme Al Anouti, Qutayba Hamid, Rabih Halwani

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The ability of Vitamin D (VitD) to modulate antiviral responses through induction of antimicrobial peptide is well established. However, the effect of VitD on host responses to SARS-CoV-2 is not well investigated. We here report the ability of VitD to enhance host IFN-alpha/beta (a/β) signaling both in vitro and among severe COVID-19 patients treated with VitD. Blood and saliva specimens were obtained from severe COVID-19 patients treated (43 patients), or not (37 patients), with vitD, during their stay in intensive care unit. Patients were followed up to 29 days following admission, and patient survival outcomes were collected. Higher activity levels …

Climate Anxiety, Wellbeing And Pro-Environmental Action: Correlates Of Negative Emotional Responses To Climate Change In 32 Countries, Charles A. Ogunbode, Rouven Doran, Daniel Hanss, Maria Ojala, Katariina Salmela-Aro, Karlijn L. Van Den Broek, Navjot Bhullar, Sibele D. Aquino, Tiago Marot, Julie Aitken Schermer, Anna Wlodarczyk, Su Lu, Feng Jiang, Daniela Acquadro Maran, Radha Yadav, Rahkman Ardi, Razieh Chegeni, Elahe Ghanbarian, Somayeh Zand, Reza Najafi, Joonha Park, Takashi Tsubakita, Chee Seng Tan, John Bosco Chika Chukwuorji, Kehinde Aderemi Ojewumi, Hajra Tahir, Mai Albzour, Marc Eric S. Reyes

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This study explored the correlates of climate anxiety in a diverse range of national contexts. We analysed cross-sectional data gathered in 32 countries (N = 12,246). Our results show that climate anxiety is positively related to rate of exposure to information about climate change impacts, the amount of attention people pay to climate change information, and perceived descriptive norms about emotional responding to climate change. Climate anxiety was also positively linked to pro-environmental behaviours and negatively linked to mental wellbeing. Notably, climate anxiety had a significant inverse association with mental wellbeing in 31 out of 32 countries. In contrast, it …

Efficient Framework For Brain Tumor Detection Using Different Deep Learning Techniques, Fatma Taher, Mohamed R. Shoaib, Heba M. Emara, Khaled M. Abdelwahab, Fathi E. Abd El-Samie, Mohammad T. Haweel

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The brain tumor is an urgent malignancy caused by unregulated cell division. Tumors are classified using a biopsy, which is normally performed after the final brain surgery. Deep learning technology advancements have assisted the health professionals in medical imaging for the medical diagnosis of several symptoms. In this paper, transfer-learning-based models in addition to a Convolutional Neural Network (CNN) called BRAIN-TUMOR-net trained from scratch are introduced to classify brain magnetic resonance images into tumor or normal cases. A comparison between the pre-trained InceptionResNetv2, Inceptionv3, and ResNet50 models and the proposed BRAIN-TUMOR-net is introduced. The performance of the proposed model is …

Developing A Lifestyle Intervention Program For Overweight Or Obese Preconception, Pregnant And Postpartum Women Using Qualitative Methods, Chee Wai Ku, Shu Hui Leow, Lay See Ong, Christina Erwin, Isabella Ong, Xiang Wen Ng, Jacinth Jia Xin Tan, Fabian Yap, Jerry K. Y. Chan, See Ling Loy

Research Collection School of Social Sciences

The time period before, during and after pregnancy represents a unique opportunity for interventions to cultivate sustained healthy lifestyle behaviors to improve the metabolic health of mothers and their offspring. However, the success of a lifestyle intervention is dependent on uptake and continued compliance. To identify enablers and barriers towards engagement with a lifestyle intervention, thematic analysis of 15 in-depth interviews with overweight or obese women in the preconception, pregnancy or postpartum periods was undertaken, using the integrated-Promoting Action on Research Implementation in Health Services framework as a guide to systematically chart factors influencing adoption of a novel lifestyle intervention. …

When Intelligence Hurts And Ignorance Is Bliss: Global Pandemic As An Evolutionarily Novel Threat To Happiness, Satoshi Kanazawa, Norman P. Li, Jose C. Yong

Research Collection School of Social Sciences

Introduction: The savanna theory of happiness posits that it is not only the current consequences of a given situation that affect happiness but also its ancestral consequences, and that the effect of ancestral consequences on happiness is stronger among less intelligent individuals. But what about situations that did not exist in the ancestral environment and thus have no ancestral consequences? Global pandemic is one such situation that has no ancestral analog, and the theory predicts such evolutionarily novel threats to have a negative effect disproportionately on the life satisfaction of more intelligent individuals.Methods: We analyzed prospectively longitudinal data from population …

Association Between Depression, Happiness, And Sleep Duration: Data From The Uae Healthy Future Pilot Study, Mitha Al Balushi, Sara Al Balushi, Syed Javaid, Andrea Leinberger-Jabari, Fatma Al-Maskari, Mohammed Al-Houqani, Ayesha Al Dhaheri, Abdullah Al Nuaimi, Abdullah Al Junaibi, Naima Oumeziane, Marina Kazim, Aisha Al Hamiz, Muna Haji, Ayesha Al Hosani, Leila Abdel Wareth, Wael Almahmeed, Habiba Alsafar, Fatme Alanouti, Eiman Al Zaabi, Claire K. Inman, Omar El Shahawy, Michael Weitzman, Ann Marie Schmidt, Scott Sherman, Abdishakur Abdulle, Amar Ahmad, Raghib Ali

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Background: The United Arab Emirates Healthy Future Study (UAEHFS) is one of the first large prospective cohort studies and one of the few studies in the region which examines causes and risk factors for chronic diseases among the nationals of the United Arab Emirates (UAE). The aim of this study is to investigate the eight-item Patient Health Questionnaire (PHQ-8) as a screening instrument for depression among the UAEHFS pilot participants. Methods: The UAEHFS pilot data were analyzed to examine the relationship between the PHQ-8 and possible confounding factors, such as self-reported happiness, and self-reported sleep duration (hours) after adjusting for …

Xanthium Spinosum L. Extracts Inhibit Breast Cancer In Mice By Apoptosis Induction And Immune System Modulation, Lina T. Al Kury, Zainab Taha, Asma Ismail Mahmod, Wamidh H. Talib

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Plants have been considered for many years as an important source of medicine to treat different diseases. Xanthium spinosum L. (Asteraceae, Compositae) is known for its diuretic, anti-inflammatory, and sedative effects. It is also used in the treatment of several ailments, such as cancer. In order to evaluate the anticancer and immunomodulatory activities, crude ethanol extract was prepared from the aerial part of X. spinosum and then fractionated using solvents with different polarities. As well, the chemical composition of X. spinosum extract and fractions were identified using LC-MS analysis. The antitumor effect of X. spinosum was assessed in both in …

The Host Mir-17-92 Cluster Negatively Regulates Mmtv Replication By Targeting Its Genomic Rna Via Mir-92a, Jasmin Baby

Dissertations

The mouse mammary tumor virus (MMTV) is a milk-borne infectious agent capable of inducing mammary tumors primarily and to some extent, T-cell leukemias/lymphomas in mice. While MMTV has typically been employed to investigate fundamental processes in breast cancer initiation and progression, very little is known about the virus-host interplay during this process. MicroRNAs (miRNAs) are renowned master regulators of the transcriptome that influence key cellular activities, including anti-viral pathways that combat incoming viral infections. A recent study from our group revealed that unlike some retroviruses like bovine leukemia virus (BLV), MMTV does not encode virally-encoded miRNAs (v-miRs); rather, it perturbs …

Impaired Cytokines Gene Expression By Diazinon And Its Relation With Blood Chemistry And Oxidative Stress Biomarkers In Nile Tilapia (Oreochromis Niloticus), Mahmoud El Sebaei, Mohammad Shathele, Sabry Mohamed El-Bahr

The Thai Journal of Veterinary Medicine

Diazinon (DZN) is a promising broad-spectrum organophosphorus insecticide. There is no evidence to support the hypothesis that DZN alters cytokine gene expression and that these modifications have an immediate impact on the histopathology, blood chemistry and oxidative stress in Nile tilapia (Oreochromis niloticus). Therefore, 225 fish were divided into one control group and four treatment groups (45 fish/group; 3 replicates/group; 15 fish/ replicate). Fish in the control group were supplied with water free of DZN. Fish in the treatment groups (T1-T4) were intoxicated with DZN at 0.28 mg/L for 1, 2, 3 and 4 weeks, respectively. Activities of AST and …

Multiplex Sybr Green Real-Time Rt-Pcr Assays For The Improved Detection Of Viral Pathogens In Horses: Equine Infectious Anemia, West Nile And Japanese Encephalitis Viruses, Sunutcha Suntrarachun, Surasak Akesowan, Suchitra Khunsup

The Thai Journal of Veterinary Medicine

Equine infectious anemia virus (EIAV), West Nile virus (WNV) and Japanese encephalitis virus (JEV) are mosquito-borne viruses that are of great concern for the equine industry worldwide. These viruses produce similar clinical signs and veterinarians need to be able to differentiate between them quickly. In this study, multiplex known as duplex and triplex SYBR Green real-time RT-PCR assays were developed to detect these three viruses and to discriminate between them based on differences in the melting temperatures (Tm) of their amplification products. Three melting peaks, generated simultaneously at temperatures of 78.5±0.5°C, 83.5±0.5°C and 85.0±1.0°C, indicated the presence of EIAV, JEV …

Effect Of Lameness On Daily Milk Yield In Dairy Cow, Piyanat Prasomsri

The Thai Journal of Veterinary Medicine

Being aware of the impact of lameness on milk production is necessary to encourage farmers to pay more attention to this issue. Therefore, we need evidence that presents the production loss due to lameness. This can be applied to make the farmers realize the importance of lameness. This study aims to examine the impact of lameness on daily milk yield based on data obtained from cow level in a large dairy farm with 2 units in Thailand. The crossbred Holstein Friesian cows were evaluated for the degree of lameness by locomotion score (LS) monthly for 8 consecutive months. Cows were …

Unravelling The Productivity Rate Of Selective Media For Brucella Strains, Mustafa Sencer Karagul, Serkan Ikiz

The Thai Journal of Veterinary Medicine

The aim of this study is to reveal the productivity rate of selective media for Brucella strains. Brucella selective media namely Farrell’s medium, CITA, Modified Thayer-Martin, Jones-Morgan medium and one additional medium including erythritol and antibiotics were compared within the scope of productivity rate and colony growth in time. The comparison was carried out using 14 strains including Brucella abortus biovars, S19 vaccine strain, Brucella suis biovars and Brucella ovis. Erythritol addition showed a positive effect on colony growth in time. In addition to differences between the productivity rates of the media; there was also some variation in the colony …

Mind The Gaps: Assessing And Enhancing The Trustworthiness Of Mental Health Apps, Gary Kok Yew Chan

Research Collection Yong Pung How School Of Law

Mental health apps including artificial intelligence (“AI”)- powered apps and chatbots have raised serious concerns relating to safety, efficacy and privacy. This article assesses their trustworthiness based on lego-regulatory, ethical and technological measures in addressing the abovementioned concerns. Focusing on applications to mental health apps, it examines Singapore laws, regulations and guidelines relating to software-based and AI medical devices, data protection, consumer protection, advertising and medical negligence. Additionally, upon taking into account other non-binding ethical guidelines, certification standards and technological measures targeted at app developers, a few recommendations are offered for enhancing trust in mental health apps.

Associations Between Dietary Intake Of Vitamin D, Sun Exposure, And Generalized Anxiety Among College Women, Fatme Al Anouti, William B. Grant, Justin Thomas, Sharifa Alblooshi, Spyridon Karras

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Vitamin D insufficiency impacts about half of the population worldwide. Almost one billion individuals across all ages and ethnicities suffer from vitamin D deficiency. Hypovitaminosis D is mainly related to lifestyle choices and habits, such as outdoor activities and food intake. Several studies have demonstrated a correlation between vitamin D status and anxiety symptoms. The main purpose of this study was to investigate the correlation between anxiety and factors including age, vitamin D deficiency, citizens, dietary and supplementary vitamin D intake, along with sun exposure, among a sample of female college students in the United Arab Emirates. A descriptive questionnaire, …

Mapping Agricultural Soil In Greenhouse Using An Autonomous Low-Cost Robot And Precise Monitoring, Amine Saddik, Rachid Latif, Fatma Taher, Abdelhafid El Ouardi, Mohamed Elhoseny

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Our work is focused on developing an autonomous robot to monitor greenhouses and large fields. This system is designed to operate autonomously to extract useful information from the plants based on precise GPS localization. The proposed robot is based on an RGB camera for plant detection and a multispectral camera for extracting the different special bands for processing, and an embedded architecture integrating a Nvidia Jetson Nano, which allows us to perform the required processing. Our system uses a multi-sensor fusion to manage two parts of the algorithm. Therefore, the proposed algorithm was partitioned on the CPU-GPU embedded architecture. This …

Preclinical Behavioral Assessments Of Mitraginyne, The Main Psychoactive Alkaloid In Kratom, Rachel Burroughs

Dissertations

Mitragyna speciosa (kratom) is a medicinal plant indigenous to Southeast Asia and Africa with a long history of use for a variety of ailments, including diarrhea, pain relief, cough suppression, and amelioration of opiate withdrawal symptoms. Despite its status as an herbal remedy, kratom is banned in some countries due to a myriad of negative health risks. Preclinical psychopharmacology studies of mitragynine (MG), the main alkaloid of kratom, indicate it has opioid-like effects at higher doses and psychostimulant-like effects at lower doses. The current study utilized three rodent behavioral paradigms to evaluate the putative psychostimulant effects of MG. The specific …

Shifting Our Lens: Practical Trauma-Informed Approaches For Educators, Charity Garcia, Ingrid Weiss Slikkers, Tara Bailey

Faculty Publications

No abstract provided.

Protocol Implementation For Standardized Handoff From Emergency Department, Marina Conaway

Symposium of Student Scholars

In the healthcare field, report given between nurses during handoff when transferring and admitting patients is considered one of the most important components to quality patient care as well as ensuring patient safety. When report is not given effectively or at all during handoff, there are many problems that can occur during the nursing care process. According to research, lack of including necessary patient information or having incomplete medical records are some of the main problems that can lead to things directly affecting patient safety and quality of care, such as medication errors. Research supports that continuity of care is …