Medicine and Health Sciences Commons^™

Health Educator Experience: Recommendations For Physical Activity For Mental Health In Women, Patricia Schneider

Walden Dissertations and Doctoral Studies

Mental health issues, specifically anxiety and depression, continue to be a public health crisis in the United States. Despite the established therapies of pharmacology and cognitive behavioral therapy, not all patients seek or find relief using these methods. Therefore, other treatment strategies need to be studied. The purpose of this basic qualitative study was to understand the experiences of health educators who use physical activity as a strategy for anxiety and depression management among middle-aged women as well as their own attitudes, norms, and perceived behavioral controls. The theory of planned behavior (TPB) was leveraged as the theoretical foundation for …

Increasing Nurse Leader Knowledge And Awareness Of Information And Communication Technologies, Cory Stephens

Walden Dissertations and Doctoral Studies

Due to the recent coronavirus disease (COVID-19) pandemic, rapid technological innovation and nursing practice transformation exposed a deepening divide in the knowledge and awareness of information and communication technologies (ICT) among nurses. This technological skills gap undermines the benefits of ICT to nursing practice such as increased nurse satisfaction, improved care quality, and reduced costs. Nurse leaders are positioned to promote the use of ICT among nurses but may suffer from the same knowledge deficit of ICT as their followers. Guided by Locsin’s technological competencies as caring in nursing theory, Staggers and Parks’ nurse-computer interaction framework, and Covell’s nursing intellectual …

Relationship Between Ceo Gender, Hospital Size, And Urban, Rural Location, Levinda Walpole

Walden Dissertations and Doctoral Studies

Leadership diversity concerning gender is important in the health care sector because diversity encourages problem solving from different perspectives. The purpose of this quantitative correlational study was to examine whether there was a relationship between CEO gender and the size of nonprofit hospitals and rural/urban location of hospitals in Texas. The independent variables were hospital bed size, which was categorized according to various groupings, and rural/urban areas in Texas. The dependent variable was gender (male and female). The theoretical framework that grounded this study was the perspective of organizational culture and the leader’s role based on the competing values framework. …

Services For Homeless Veterans: A Study Of Access To Benefits, Sheryl Maddox Williams

Walden Dissertations and Doctoral Studies

AbstractHomelessness among veterans in the United States is a multifaceted social and health concern that has continued to increase despite immense efforts to minimize and eliminate this issue. Numerous organizations have dedicated resources; however, many veterans do not use benefits and resources that are available to them, and homelessness remains a health and social concern. The purpose of this study was to explore and describe how individual and interpersonal barriers, community factors, organizational structure, and existing policies for assistance are perceived by support staff that work with veterans with mental disorders who are homeless or at risk of becoming homeless. …

Opioid Naloxone Education Clinical Practice Guideline, Tat'yana Sahleem Alethia Worthy

Walden Dissertations and Doctoral Studies

As a result of an institution-wide campaign to train providers on the administration of opioid reversal agents within a large medical center in the northeastern United States, the practice problem emerged that there was no patient/family education document for healthcare providers to use as a guide to educate patients on opioid risk and proper administration of naloxone to prevent opioid overdose in the outpatient setting. This scholarly project used an interprofessional team to develop comprehensive opioid naloxone education guidelines to close the gap in clinical practice. The purpose of this project was to develop a patient education clinical practice guideline …

Gestational Weight Gain, Level Of Education, And Infant Mortality Among African American Women, George Lee Amanambu

Walden Dissertations and Doctoral Studies

Abstract

African American (AA) women in Mississippi have a higher burden of infant mortality, especially those with low income and educational levels, as compared to other regions of the country. However, it is unknown if abnormal gestation weight gain (GWG) is contributing to this increased burden. This quantitative cross-sectional study examined the association between GWG (25-35lbs), level of education, income, and infant mortality among AA women with normal prepregnancy body weight who were between 30 to 47 years old in the state of Mississippi from 2016 to 2018. Biopsychosocial and ecosocial models were used as the theoretical foundation to design …

Transcranial Magnetic Stimulation For Post-Traumatic Stress Disorder, Amber N. Edinoff, Tanner L. Hegefeld, Murray Petersen, James C. Patterson, Christopher Yossi, Jacob Slizewski, Ashley Osumi, Elyse M. Cornett, Adam M. Kaye, Jessica S. Kaye, Vijayakumar Javalkar, Omar Viswanath, Ivan Urits, Alan David Kaye

School of Pharmacy Faculty Articles

Post-traumatic stress disorder (PTSD) is a psychiatric disorder that causes significant functional impairment and is related to altered stress response and reinforced learned fear behavior. PTSD has been found to impact three functional networks in the brain: default mode, executive control, and salience. The executive control network includes the dorsolateral prefrontal cortex (DLPFC) and lateral PPC. The salience network involves the anterior cingulate cortex, anterior insula, and amygdala. This latter network has been found to have increased functional connectivity in PTSD. Transcranial Magnetic Stimulation (TMS) is a technique used in treating PTSD and involves stimulating specific portions of the brain …

Combination Olanzapine And Samidorphan For The Management Of Schizophrenia And Bipolar 1 Disorder In Adults: A Narrative Review, Hannah W. Haddad, Elena Boardman, Brooke Williams, Rama Mouhaffel, Adam M. Kaye, Alan David Kaye

School of Pharmacy Faculty Articles

Schizophrenia is a debilitating psychotic disorder characterized by positive symptoms such as delusions, hallucinations, and disorganized thoughts, and negative symptoms like lack of effect or motivation. Bipolar 1 disorder (B1D) is a psychiatric illness characterized by recurrent manic episodes in alternation with depressive episodes and interspersed periods of euthymia, ultimately resulting in psychological distress and impairment of daily functioning. Effective treatments are needed for both schizophrenia and B1D to reach the treatment goals of reducing the debilitating symptomology, improving social functioning and quality of life, and increasing the chances of recovery and more favorable long-term outcomes. To date, olanzapine is …

Opicapone, A Novel Catechol-O-Methyl Transferase Inhibitor, For Treatment Of Parkinson's Disease "Off" Episodes, Amnon A. Berger, Ariel Winnick, Jonathan Izygon, Binil M. Jacob, Jessica S. Kaye, Rachel J. Kaye, Elisa E. Neuchat, Adam M. Kaye, Edward S. Alpaugh, Elyse M. Cornett, Andrew H. Han, Alan David Kaye

School of Pharmacy Faculty Articles

Parkinson's Disease (PD) is a common neurodegenerative disorder and the leading cause of disability. It causes significant morbidity and disability through a plethora of symptoms, including movement disorders, sleep disturbances, and cognitive and psychiatric symptoms. The traditional pathogenesis theory of PD involves the loss of dopaminergic neurons in the substantia nigra (SN). Classically, treatment is pursued with an assortment of medications that are directed at overcoming this deficiency with levodopa being central to most treatment plans. Patients taking levodopa tend to experience "off episodes" with decreasing medication levels, causing large fluctuations in their symptoms. These off episodes are disturbing and …

Pitolisant, A Novel Histamine-3 Receptor Competitive Antagonist, And Inverse Agonist, In The Treatment Of Excessive Daytime Sleepiness In Adult Patients With Narcolepsy, Noeen Sarfraz, David Okuampa, Hannah Hansen, Mark R. Alvarez, Elyse M. Cornett, Juyeon Kakazu, Adam M. Kaye, Alan David Kaye

School of Pharmacy Faculty Articles

Narcolepsy is a debilitating sleep disorder that presents with excessive daytime sleepiness (EDS) and cataplexy, which is a sudden paralysis of muscle tone triggered by strong emotions such as laughing. It is also associated with many other disorders, including psychiatric disorders, neurologic illnesses, and medication side effects. Common causes of delayed and incorrect diagnoses of these conditions include lack of physician familiarity with narcolepsy symptoms and comorbidities which mask narcolepsy signs and symptoms. Current pharmacologic therapies include Modafinil and Armodafinil for EDS and sodium oxybate for cataplexy. This review discusses the epidemiology, pathophysiology, risk factors, presentation, treatment of narcolepsy, and …

Selective Serotonin Reuptake Inhibitors And Associated Bleeding Risks: A Narrative And Clinical Review., Amber N. Edinoff, Keerthiga Raveendran, Marc A. Colon, Bennett H. Thomas, Katie A. Trettin, Grace W. Hunt, Adam M. Kaye, Elyse M. Cornett, Alan David Kaye

School of Pharmacy Faculty Articles

Major Depressive Disorder (MDD) is a major cause of disability worldwide and is associated with serious lasting impairment. A leading hypothesis of the pathophysiology of MDD is the monoamine deficiency hypothesis which suggests that depression is caused by depletion of serotonin, norepinephrine, or dopamine in the central nervous system. Serotonin is the most widely studied neurotransmitter in the pathophysiology of depression, with studies showing that reduced central serotonin synthesis leads to depressive symptoms in individuals at risk for depression. Selective Serotonin Reuptake Inhibitors (SSRI) inhibit serotonin reuptake and subsequently increase the amount of serotonin available in synapses. Common side effects …

Viloxazine, A Non-Stimulant Norepinephrine Reuptake Inhibitor, For The Treatment Of Attention Deficit Hyperactivity Disorder: A 3 Year Update., Hannah W. Haddad, Paul B. Hankey, Jimin Ko, Zahaan Eswani, Pravjit Bhatti, Amber N. Edinoff, Adam M. Kaye, Alan David Kaye

School of Pharmacy Faculty Articles

Attention deficit hyperactivity disorder (ADHD) is the most common neurodevelopmental disorder in childhood. Current treatment options for ADHD include pharmacological treatment (stimulants, non-stimulants, anti-depressants, anti-psychotics), psychological treatment (behavioral therapy with or without parent training, cognitive training, neurofeedback), and complementary and alternative therapies (vitamin supplementation, exercise). Central nervous system (CNS) stimulants are the primary pharmacological therapy used in treatment; however, these stimulant drugs carry a high potential for abuse and severe psychological/physical dependence. Viloxazine, a non-stimulant medication without evidence of drug dependence, is a selective norepinephrine reuptake inhibitor that has historically been prescribed as an anti-depressant medication. The extended-release (ER) form …

Buprenorphine And Its Formulations: A Comprehensive Review., Salomon Poliwoda, Nazir Noor, Jack S. Jenkins, Cain W. Stark, Mattie Steib, Jamal Hasoon, Giustino Varrassi, Ivan Urits, Omar Viswanath, Adam M. Kaye, Alan David Kaye

School of Pharmacy Faculty Articles

Buprenorphine, a novel long-acting analgesic, was developed with the intention of two purposes: analgesia and opioid use disorder. Regarding its pharmacodynamics, it is a partial agonist at mu receptors, an inverse agonist at kappa receptors, and an antagonist at delta receptors. For the purpose of analgesia, three formulations of buprenorphine were developed: IV/IM injectable formulation (Buprenex®), transdermal patch formulation (Butrans®), and buccal film formulation (Belbuca®). Related to opioid dependence, the formulations developed were subcutaneous extended release (Sublocade®), subdermal implant (Probuphine®), and sublingual tablets (Subutex®). Lastly, in order to avoid misuse of buprenorphine for opioid dependence, two combination formulations paired with …

Midazolam Nasal Spray To Treat Intermittent, Stereotypic Episodes Of Frequent Seizure Activity: Pharmacology And Clinical Role, A Comprehensive Review., Elyse M. Cornett, Meskerem A. Nemomsa, Bailey Turbeville, Matthew A. Busby, Jessica S. Kaye, Aaron J. Kaye, Joohee Choi, Giovanni F. Ramírez, Giustino Varrassi, Adam M. Kaye, Alan David Kaye, James Wilson, Latha Ganti

School of Pharmacy Faculty Articles

An intranasal formulation of midazolam, Nayzilam, has been FDA-approved to treat intermittent, stereotypic episodes of frequent seizure activity. Nayzilam is easy to administer and can quickly treat seizures that occur outside of the hospital. The intra-nasal route of administration allows non-medical personal to administer the drug which makes it more accessible and user-friendly in the event of a seizure. Many studies have indicated quick cessation of seizures with Nayzilam compared to rectal diazepam, which has been the standard of care treatment. Nayzilam has been proven to be safe and effective for acute seizures in children, deeming it a revolutionary alternative …

Phenothiazines And Their Evolving Roles In Clinical Practice: A Narrative Review., Amber N. Edinoff, Grace Armistead, Christina A. Rosa, Alexandra Anderson, Ronan Patil, Elyse M. Cornett, Kevin S. Murnane, Adam M. Kaye, Alan David Kaye

School of Pharmacy Faculty Articles

Phenothiazines, a diverse class of drugs, can be used to treat multiple mental health and physical conditions. Phenothiazines have been used for decades to treat mental illnesses, including schizophrenia, mania in bipolar disorder, and psychosis. Additionally, these drugs offer relief for physical illnesses, including migraines, hiccups, nausea, and vomiting in both adults and children. Further research is needed to prove the efficacy of phenothiazines in treating physical symptoms. Phenothiazines are dopaminergic antagonists that inhibit D2 receptors with varying potency. High potency phenothiazines such as perphenazine are used to treat various psychiatric conditions such as the positive symptoms of schizophrenia, the …

Aduhelm, A Novel Anti-Amyloid Monoclonal Antibody, For The Treatment Of Alzheimer's Disease: A Comprehensive Review., Hannah W. Haddad, Garett W. Malone, Nicholas J. Comardelle, Arielle E. Degueure, Salomon Poliwoda, Rachel J. Kaye, Kevin S. Murnane, Adam M. Kaye, Alan David Kaye

School of Pharmacy Faculty Articles

Alzheimer's disease (AD) is the most common form of dementia affecting millions of individuals, including family members who often take on the role of caregivers. This debilitating disease reportedly consumes 8% of the total United States healthcare expenditure, with medical and nursing outlays accounting for an estimated $290 billion. Cholinesterase inhibitors and N-methyl-D-aspartate receptor antagonists have historically been the most widely used pharmacologic therapies for patients with AD; however, these drugs are not curative. The present investigation describes the epidemiology, pathophysiology, risk factors, presentation, and current treatment of AD followed by the role of the novel monoclonal antibody, Adulhelm, in …

Rimegepant For The Treatment Of Migraine., Amnon A. Berger, Ariel Winnick, Austin H. Carroll, Alexandra Welschmeyer, Nathan Li, Marc Colon, Antonella Paladini, Giovanni F. Ramírez, Jamal Hasoon, Elyse M. Cornett, Jaehong Song, Giustino Varrassi, Adam M. Kaye, Alan David Kaye, Latha Ganti

School of Pharmacy Faculty Articles

Migraine is a common form of primary headache, affecting up to 1 in every 6 Americans. The pathophysiology is an intricate interplay of genetic factors and environmental influence and is still being elucidated in ongoing studies. The trigeminovascular system is now known to have a significant role in the initiation of migraines, including the release of pain mediators such as CGRP and substance P. Traditional treatment of migraine is usually divided into acute and preventive treatment. Acute therapy includes non-specific therapy, such as NSAIDs and other analgesics, which may provide relief in mild to moderate migraines. 5-HT1 agonists may provide …

Reliability Of The Gymsafe Movement Screen To Predict Health And Biomechanical Faults In Female Gymnasts, Jennifer Kinder, Alyssa Herrera-Set, Jessica Wickizer, Claire Mauriel, Rachel Spivak, Joy Kuo, Todd E. Davenport

School of Pharmacy Faculty Articles

Background: Women’s gymnastics ranks second highest in collegiate sports for injuries. The gymSAFE Movement Screen (GMS) is the first screening application to identify areas associated with mechanisms of injury in gymnastics. Purpose: Investigate reliability of GMS scores between two physical therapists who varied in experience with gymnastics. Methods: 25 female gymnasts, between 5-16 years of age, were screened by two physical therapists. Percent agreement and intraclass correlation coefficients (ICCs) of scores were analyzed. Findings: ICC for total scores was .71 (95% CI (p<.002) for the first measurement and 0.51 (p <.043) for the second. Percent agreement fundamental gymnastic movements items ranged from 42.4% to 77.6%, and 84.6% to 92.3% for the strength and flexibility items. Clinical Relevance: A universal screen can assist in interdisciplinary care for female gymnasts. Conclusions: Overall, the physical therapists were strongly comparable especially in areas of strength and flexibility. Training for concordance appears necessary for fundamental gymnastics movement subscale because agreement was more variable.

Effects Of Tommy John Surgery, Draft Order, And Monetary Factors On The Value Of Pitchers In Major League Baseball, Jonathan P. Wong

University of the Pacific Theses and Dissertations

The purpose of this thesis is to determine what effects draft order, monetary earnings, and Tommy John Surgery (TJS) have on the perceived value of a pitcher in Major League Baseball (MLB). For the context of this thesis, value will be defined as a player's ability to contribute to their team's wins in a positive manner. TJS has become synonymous with MLB and baseball as a sport, and many are either skeptical of its effects or over-assuming of its benefits. The three aforementioned areas of concerns were used to structure the thesis, as each dependent outcome is analyzed in a …

Generational Differences In Nursing Turnover, Adam Bennett

Walden Dissertations and Doctoral Studies

Nursing is currently the largest job category in U.S. health care requiring proper recruitment and retention of nurses. As the current generation of nurses ages out of the workforce due to retirement, new nurses will need to cover the gaps in the workforce. The purpose of this quantitative correlational study was to examine the relationship between voluntary turnover, involuntary turnover, and career change among nurses who were born between 1980 and 1995 (Millennials) and those born between 1965 and 1979 (Generation X). The theoretical framework was Mannheim’s theory of generations. Secondary data were collected from exit interviews with 811 respondents …

Factors That Determine Utilization Of The Canadian School-Based Human Papilloma Virus Vaccine Programs, Diane Gloria Brown

Walden Dissertations and Doctoral Studies

Human Papilloma Virus (HPV) is the most common sexually transmitted infection in the world and is the known causative agent of many HPV-associated cancers in both males and females. HPV vaccination rates in Canada are significantly lower than other developed countries and this finding is poorly understood as Canadian adolescents have access to free-of-charge HPV vaccines through school-based vaccination programs. This quantitative descriptive study used an online survey to collect data from 992 eligible respondents. This study identified predisposing, enabling, and need factors characterized by the Andersen behavioral model of health services use which facilitate or impede the use of …

Secondary Data Analysis Of The Association Of Screen Time With Selected Health Behaviors, Kellany Cadogan Noland

Walden Dissertations and Doctoral Studies

The noticeable disparity in youth access of preventive healthcare and youth’s tendency towards excessive screen time have been linked to poor health outcomes. This issue prompted the current study, which had three core purposes: to identify associations between screen time and selected health behaviors, to identify target sociocultural and personal determinants of youth health, and to provide evidence to prompt innovation in promoting youth health via screen-based strategies. The social cognitive theory provided a context for triadic reciprocity between youth personal factors, environmental factors, and behaviors. A quantitative secondary analysis was completed using SPSS-27 to identify whether there was an …

Nurses' Experiences Caring For Patients With Opioid Use Disorder, Pamella Maureen Campbell

Walden Dissertations and Doctoral Studies

Over the past 2 decades, opioid use in the United States has taken thousands of lives, reached the level of epidemic in 2017, and has been an area of study among scholars. The problem is health care professionals, including nurses, lack training on how to care for people with opioid use disorder (OUD). Nurses are at the frontline of patient care and understanding the nurses’ experiences in the care of patients with OUD may help to improve the patients’ quality of care. The purpose of this qualitative descriptive study was to develop an understanding of the experiences of nurses with …

Fall Clinical Practical Guideline In A Psychiatric Hospital, Wendy Carroll Smith

Walden Dissertations and Doctoral Studies

Psychiatric hospitals are a unique environment and therefore pose unique challenges in preventing falls. Current evidence suggests that multidisciplinary committees to update clinical practice guidelines (CPG) will reduce falls and improve patient care in the acute inpatient psychiatric setting. The purpose of this study was to examine current evidence and develop new CPG with a goal to decrease falls in an inpatient psychiatric hospital. The Iowa model collaborative was used as a framework to develop the CPG to promote quality care and serve as an implementation model that supports the training of evidence-based practice. The methodology, design, and data analysis …

Why The Recognition Of Sentience Is So Important For Animal Welfare, Mark Jones

Animal Sentience

Rowan et al. (2022) provide a useful summary of the history and development of the philosophical, public, and legal recognition of animal sentience and its importance in improving the welfare of animals. Here I argue for the incorporation of the precautionary principle in sentience recognition, and the wider significance of sentience recognition to the current climate, biodiversity and human health crises.

Psychological Predictors Of Advanced Cancer Patients' Preferences For Return Of Results From Comprehensive Tumor Genomic Profiling, Bettina Meiser, Phyllis Butow, Grace Davies, Christine Napier, Timothy Schlub, Nicci Bartley, Ilona Juraskova, Mandy Ballinger, David M. Thomas, Kathy Tucker, David Goldstein, Barbara Biesecker, Megan Best

IES Papers and Journal Articles

This study assessed the psychological predictors of preferences for return of comprehensive tumor genomic profiling (CTGP) results in patients with advanced cancers, enrolled in the Molecular Screening and Therapeutics Program. Patients completed a questionnaire prior to undergoing CTGP. Of the 1434 who completed a questionnaire, 96% would like to receive results that can guide treatment for their cancer, and preference for receiving this type of result was associated with lower tolerance of uncertainty. Sixty-four percent would like to receive results that cannot guide treatment, and lower tolerance of uncertainty, self-efficacy, and perceived importance were associated with this preference. Fifty-nine …

The Impact Of Covid-19 On Cancer Patients, Their Carers And Oncology Health Professionals: A Qualitative Study, P Butow, P E. Havard, Z Butt, I Juraskova, H Sharpe, H Dhillon, L Beatty, P Beale, M Cigolini, B Kelly, R J. Chan, L Kirsten, Megan Best, J Shaw

IES Papers and Journal Articles

Objective: Cancer patients, carers and oncology health professionals have been impacted by the COVID-19 pandemic in many ways, but their experiences and psychosocial responses to the pandemic are still being explored. This study aimed to document the experience of Australians living with cancer, family carers, and Oncology health professionals (HPs) when COVID-19 first emerged.

Methods: In this qualitative study, participants (cancer patients currently receiving treatment, family carers and HPs) completed a semi-structured interview exploring their experiences of COVID-19 and the impact it had on cancer care. Participants also completed the Hospital Anxiety and Depression Scale (patients) and the Depression, Anxiety …

Fortitude, Spiritual Fortitude, And The Cancer Care Continuum In African American Breast Cancer Survivors, Karen Y. Boone

Walden Dissertations and Doctoral Studies

African American breast cancer survivors (AABCS) struggle with physical, emotional, psychological, spiritual, and financial challenges. Navigating these challenges can require the use of inner resources such as fortitude and spiritual fortitude. Using Folkman and Lazarus’ transactional model of stress and coping as the theoretical framework, the purpose of this study was to examine fortitude and spiritual fortitude as coping responses by African American women living with breast cancer and whether fortitude and spiritual fortitude were associated with phases of the cancer care continuum. A quantitative nonexperimental cross-sectional design was used for primary data collection that involved using Pretorius’ Fortitude Questionnaire …

The Impact Of Electronic Health Records Meaningful Use On Patient Safety And Satisfaction, Paulette Brown

Walden Dissertations and Doctoral Studies

AbstractThe widespread adoption of electronic health records (EHRs) is encouraged because of their potential to improve the quality of care provided. It was unknown to what extent the meaningful use of EHRs would impact patient safety and satisfaction in general and specialty hospitals. The researcher’s purpose for this quantitative correlational research was to examine the impact of meaningful EHR use of EHRs on patient safety and satisfaction outcomes in general and specialty hospitals in Philadelphia (PA). The constructs of the institutional theory guided the study. The hypotheses that guided the study included (a) Meaningful EHR use positively influences patient satisfaction …

The Relationship Between First Case On-Time Starts, Turnover Times, And Operating Room Productivity, Rhafia Bucoy

Walden Dissertations and Doctoral Studies

Operating room (OR) managers struggle to manage day-to-day surgical operations while meeting and exceeding organizational productivity amid the COVID-19 pandemic. The deferral of surgeries contributes to millions of backlogs of surgical case volume and unintended negative consequences. Grounded in the proposition that first-case on-time starts (FCOTS) and turnover time (TOT) are correlates of OR productivity, the purpose of this quantitative correlational study was to examine the relationship between FCOTS, TOT, and OR productivity. Archival data from 136 electronic surgical records were collected from two free-standing ambulatory surgery centers and analyzed using multiple regression. The results of the one-service, eye-specialized, ambulatory …