Medicine and Health Sciences Commons^™

Effects Of A Demand-Valve Scuba Regulator On Cardiorespiratory Response During Submaximal Exercise Under Normobaric Conditions: A Preliminary Investigation, Christopher R. Kovacs Ph.D., Camille Dhom B.S.

International Journal of Aquatic Research and Education

SCUBA diving fatalities are often related to cardiac events triggered by stress linked to equipment. The purpose of this investigation was to examine the effects of a SCUBA regulator on cardiorespiratory exercise at a submaximal workload. Ten participants (mean = 21.5 yrs; s.d. = 1.16) completed two submaximal exercise tests at 1 ATA; one while breathing normally and a second while breathing directly from a demand valve SCUBA regulator. Total time to test completion (TOT), heart rate (HR), blood pressure (BP), rating of perceived exertion (RPE), and arterial oxygen levels were all assessed. No significant differences between conditions were found …

Dna-Pkcs: A Targetable Protumorigenic Protein Kinase., Emanuela Dylgjeri, Karen E Knudsen

Department of Cancer Biology Faculty Papers

DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is a pleiotropic protein kinase that plays critical roles in cellular processes fundamental to cancer. DNA-PKcs expression and activity are frequently deregulated in multiple hematologic and solid tumors and have been tightly linked to poor outcome. Given the potentially influential role of DNA-PKcs in cancer development and progression, therapeutic targeting of this kinase is being tested in preclinical and clinical settings. This review summarizes the latest advances in the field, providing a comprehensive discussion of DNA-PKcs functions in cancer and an update on the clinical assessment of DNA-PK inhibitors in cancer therapy.

2022-02-15_Michiganoverview_Covidlongtermcare, Michigan Department Of Health & Human Services

Michigan COVID-19 Long Term Care Data

The COVID Long Term Care Facilities page was obtained from Michigan's COVID-19 data page: https://www.michigan.gov/coronavirus/0,9753,7-406-98163_98173-526911--,00.html.

This report is created by the Michigan Department of Health & Human Services from data self-reported by long-term care facilities into EMResource. Data for all reporting facilities is posted weekly each Monday.

The information below represents COVID-19 data reported directly to MDHHS by licensed and operating Skilled Nursing, Home for the Aged and Adult Foster Care facilities (licensed to serve 13 or more individuals) in Michigan from January 1, 2020. All long-term care facilities additionally have an obligation to report COVID-positive residents and/or staff …

Examining Youth Conceptualizations Of Water Safety Behaviors Among Participants In A Learn-To-Swim Program, Austin R. Anderson, Kristina R. Anderson, William D. Ramos, Angela K. Beale-Tawfeeq

International Journal of Aquatic Research and Education

Drowning represents a leading cause of unintentional deaths among children. Concomitantly, while formal swim instruction often incorporates water safety practices, the efficacy of these messages remains largely unexplored. This qualitative-based study sought to evaluate how youth apply learned water safety concepts when posed with a hypothetical aquatic scenario. Semi-structured interviews, augmented by use of a visual illustration prompt, were conducted with 29 participants of a youth Learn-to-Swim (LTS) program. Interviews assessed participants’ expressed water safety behaviors and were coded based on emergent themes. Findings indicated that most participants were able to identify a “struggling” swimmer in the dramatized illustration. When …

Effect Of Water Depth On Heart Rate And Core Temperature During Underwater Treadmill Walking, Carrie E. Bajenski, Brianna R. Brandon, Cailey A. Curry, Leslie Fajardo, Ryan T. Conners

International Journal of Aquatic Research and Education

Exercising using an underwater treadmill (UTM) has become a popular modality; however, few studies have focused on the physiological demands of UTM walking at varying water depths. Thus, the objective of this study was to investigate changes in heart rate (HR) and core temperature (CT) values in college-aged males and females while exercising at different water immersion depths using an UTM. Twenty participants (age = 21.50 ± 2.19 years; height = 169.04 ± 10.85cm; weight = 75.56 ± 22.28kg) walked at water depths of 10cm below the xiphoid process and at the level of the superior iliac crest (I.C.). Each …

Coronary Revascularization Versus Optimal Medical Therapy In Renal Transplant Candidates With Coronary Artery Disease: A Systematic Review And Meta-Analysis., Muhammad U Siddiqui, Joey Junarta, Gregary D. Marhefka

Department of Medicine Faculty Papers

Background Coronary artery disease (CAD) is highly prevalent in patients with chronic kidney disease and is a common cause of mortality in end-stage renal disease. Thus, patients with end-stage renal disease are routinely screened for CAD before renal transplantation. The usefulness of revascularization before transplantation remains unclear. We hypothesize that there is no difference in all-cause and cardiovascular mortality in waitlisted renal transplant candidates with CAD who underwent revascularization versus those treated with optimal medical therapy before transplantation. Methods and Results This meta-analysis was reported according to the Preferred Reporting Items for Systematic Review and Meta-Analyses guidelines. MEDLINE, Scopus, and …

Successful Treatment With Daptomycin Of Mrsa Empyema Complicated By Right-Sided Loculated Pleural Effusion Refractory To Vancomycin, Ava Torjani, Dylan Selbst, Joshua Hamsher, Sahaj Mujumdar, Andie Belkoff, Luis Taboada

Division of Internal Medicine Faculty Papers & Presentations

Empyema is a serious complication of pneumonia and has been reported to have a mortality rate of 8.7%. For methicillin-resistant Staphylococcus aureus (MRSA) empyema, treatment includes drainage and specific antibiotics such as vancomycin and linezolid. Strikingly, there are increasing incidences of empyema refractory to vancomycin and linezolid. Despite being inactivated in the lung parenchyma by pulmonary surfactant, daptomycin can penetrate the pleural space and may be better at treating MRSA empyema than vancomycin and linezolid. Some case reports have shown that daptomycin has been used to successfully treat MRSA empyema refractory to linezolid and vancomycin-resistant enterococcus (VRE) empyema. Here, we …

A Prospective Cohort Study Of The Clinical Predictors Of Bacteremia In Under-Five Children With Acute Undifferentiated Fever Attending A Secondary Health Facility In Northwestern Nigeria, Taofik Oluwaseun Ogunkunle, Timothy Olanrewaju Adedoyin, Samuel Kolade Ernest, Fatimah Hassan-Hanga, Abdulazeez Imam, Rasaq Olaosebikan, Stephen K Obaro

Department of Pharmacology and Experimental Therapeutics Faculty Papers

Background: Children with acute febrile illness with no localizing signs often receive antibiotics empirically in most resource-poor settings. However, little is known about the burden of bacteremia in this category of patients, and an appraisal is thus warranted. This will guide clinical practice and promote rational antibiotics use.

Methods: We prospectively followed up 140 under-five children who presented with acute undifferentiated fever at the emergency/outpatient pediatric unit of a secondary healthcare facility. Baseline clinical and laboratory information was obtained and documented in a structured questionnaire. We compared baseline characteristics between participants with bacteremia and those without bacteremia. We further fitted …

29 M 6 A-Rna Methylation (Epitranscriptomic) Regulators Are Regulated In 41 Diseases Including Atherosclerosis And Tumors Potentially Via Ros Regulation - 102 Transcriptomic Dataset Analyses, Ming Liu, Keman Xu, Fatma Saaoud, Ying Shao, Ruijing Zhang, Yifan Lu, Yu Sun, Charles Drummer Iv, Li Li, Sheng Wu, Satya P Kunapuli, Gerard J Criner, Jianxin Sun, Huimin Shan, Xiaohua Jiang, Hong Wang, Xiaofeng Yang

Center for Translational Medicine Faculty Papers

We performed a database mining on 102 transcriptomic datasets for the expressions of 29 m6A-RNA methylation (epitranscriptomic) regulators (m6A-RMRs) in 41 diseases and cancers and made significant findings: (1) a few m6A-RMRs were upregulated; and most m6A-RMRs were downregulated in sepsis, acute respiratory distress syndrome, shock, and trauma; (2) half of 29 m6A-RMRs were downregulated in atherosclerosis; (3) inflammatory bowel disease and rheumatoid arthritis modulated m6A-RMRs more than lupus and psoriasis; (4) some organ failures shared eight upregulated m6A-RMRs; end-stage renal failure (ESRF) downregulated 85% of m6A-RMRs; (5) Middle-East respiratory syndrome coronavirus infections modulated m6A-RMRs the most among viral infections; …

Assessment Of Photoacoustic Tomography Contrast For Breast Tissue Imaging Using 3d Correlative Virtual Histology, Gurneet S. Sangha, Bihe Hu, Guang Li, Sharon E. Fox, Andrew B. Sholl, J. Quincy Brown, Craig J. Goergen

School of Medicine Faculty Publications

Current breast tumor margin detection methods are destructive, time-consuming, and result in significant reoperative rates. Dual-modality photoacoustic tomography (PAT) and ultrasound has the potential to enhance breast margin characterization by providing clinically relevant compositional information with high sensitivity and tissue penetration. However, quantitative methods that rigorously compare volumetric PAT and ultrasound images with gold-standard histology are lacking, thus limiting clinical validation and translation. Here, we present a quantitative multimodality workflow that uses inverted Selective Plane Illumination Microscopy (iSPIM) to facilitate image co-registration between volumetric PAT-ultrasound datasets with histology in human invasive ductal carcinoma breast tissue samples. Our ultrasound-PAT system consisted …

Editor's Note, Rolando Lazaro

Philippine Journal of Physical Therapy

The Editor-in-Chief of the Philippine Journal of Physical Therapy introduces its inaugural issue.

The Women's Wrighting Group - Nurturing The Heart Of Primary Care, Elizabeth T. Toll, Selby M. Conrad

Arts & Sciences Faculty Publications

No abstract provided.

A Novel Non‑Selective Atypical Pkc Agonist Could Protect Neuronal Cell Line From A Β ‑Oligomer Induced Toxicity By Suppressing A Β Generation, Dongmei Zou, Qian Li, Wenyang Pan, Peng Chen, Miao Sun, Xiaofeng Bao

Publications and Research

Atypical protein kinase C (aPKCs) serve key functions in embryonic development by regulating apical-basal polarity. Previous studies have shed light on their roles during adulthood, especially in the development of Alzheimer's disease (AD). Although the crystal structure of PKCι has been resolved, an agonist of aPKCs remains to be discovered. In the present study, by using the Discovery Studio program and LibDock methodology, a small molecule library (K66-X4436 KINA Set) of compounds were screened for potential binding to PKCι. Subsequently, the computational docking results were validated using affinity selection-mass spectrometry, before in vitro kinase activity was used to determine the …

Explaining Correlates Of Cervical Cancer Screening Among Minority Women In The United States, Manoj Sharma, Kavita Batra, Christopher Johansen, Siddharth Raich

Social and Behavioral Health Faculty Research

Globally, cervical cancer is the fourth leading cause of death among women. While overall cervical cancer rates have decreased over the last few decades, minority women continue to be disproportionately affected compared to White women. Given the paucity of theory-based interventions to promote Pap smear tests among minority women, this cross-sectional study attempts to examine the correlates of cervical cancer screening by Pap test using the Multi-theory Model (MTM) as a theoretical paradigm among minority women in the United States (U.S.). Structural Equation Modelling (SEM) was done for testing the construct validity of the survey instrument. Data were analyzed through …

Fully Resolved Assembly Of Cryptosporidium Parvum, Vipin K Menon, Pablo C Okhuysen, Cynthia L Chappell, Medhat Mahmoud, Medhat Mahmoud, Qingchang Meng, Harsha Doddapaneni, Vanesa Vee, Yi Han, Sejal Salvi, Sravya Bhamidipati, Kavya Kottapalli, George Weissenberger, Hua Shen, Matthew C Ross, Kristi L Hoffman, Sara Javornik Cregeen, Donna M Muzny, Ginger A Metcalf, Richard A Gibbs, Joseph F Petrosino, Fritz J Sedlazeck

Faculty, Staff and Student Publications

BACKGROUND: Cryptosporidium parvum is an apicomplexan parasite commonly found across many host species with a global infection prevalence in human populations of 7.6%. Understanding its diversity and genomic makeup can help in fighting established infections and prohibiting further transmission. The basis of every genomic study is a high-quality reference genome that has continuity and completeness, thus enabling comprehensive comparative studies.

FINDINGS: Here, we provide a highly accurate and complete reference genome of Cryptosporidium parvum. The assembly is based on Oxford Nanopore reads and was improved using Illumina reads for error correction. We also outline how to evaluate and choose from …

Filtering Respiratory Motion Artifact From Resting State Fmri Data In Infant And Toddler Populations, Sydney Kaplan, Dominique Meyer, Dimitrios Alexopoulos, Deanna M Barch, Adam T Eggebrecht, Jeanette K Kenley, Cynthia E Rogers, Muriah D Wheelock, Christopher D Smyser, Et Al.

2020-Current year OA Pubs

The importance of motion correction when processing resting state functional magnetic resonance imaging (rs-fMRI) data is well-established in adult cohorts. This includes adjustments based on self-limited, large amplitude subject head motion, as well as factitious rhythmic motion induced by respiration. In adults, such respiration artifact can be effectively removed by applying a notch filter to the motion trace, resulting in higher amounts of data retained after frame censoring (e.g., "scrubbing") and more reliable correlation values. Due to the unique physiological and behavioral characteristics of infants and toddlers, rs-fMRI processing pipelines, including methods to identify and remove colored noise due to …

Fully Resolved Assembly Of Cryptosporidium Parvum, Vipin K Menon, Pablo C Okhuysen, Cynthia L Chappell, Medhat Mahmoud, Medhat Mahmoud, Qingchang Meng, Harsha Doddapaneni, Vanesa Vee, Yi Han, Sejal Salvi, Sravya Bhamidipati, Kavya Kottapalli, George Weissenberger, Hua Shen, Matthew C Ross, Kristi L Hoffman, Sara Javornik Cregeen, Donna M Muzny, Ginger A Metcalf, Richard A Gibbs, Joseph F Petrosino, Fritz J Sedlazeck

Faculty, Staff and Students Publications

BACKGROUND: Cryptosporidium parvum is an apicomplexan parasite commonly found across many host species with a global infection prevalence in human populations of 7.6%. Understanding its diversity and genomic makeup can help in fighting established infections and prohibiting further transmission. The basis of every genomic study is a high-quality reference genome that has continuity and completeness, thus enabling comprehensive comparative studies.

FINDINGS: Here, we provide a highly accurate and complete reference genome of Cryptosporidium parvum. The assembly is based on Oxford Nanopore reads and was improved using Illumina reads for error correction. We also outline how to evaluate and choose from …

Hydraulic Permeability And Compressive Properties Of Porcine And Human Synovium, Milad Rohanifar, Benjamin B Johnston, Alexandra L Davis, Young Guang, Kayla Nommensen, James A J Fitzpatrick, Christine N Pham, Lori A Setton

2020-Current year OA Pubs

The synovium is a multilayer connective tissue separating the intra-articular spaces of the diarthrodial joint from the extra-synovial vascular and lymphatic supply. Synovium regulates drug transport into and out of the joint, yet its material properties remain poorly characterized. Here, we measured the compressive properties (aggregate modulus, Young's modulus, and Poisson's ratio) and hydraulic permeability of synovium with a combined experimental-computational approach. A compressive aggregate modulus and Young's modulus for the solid phase of synovium were quantified from linear regression of the equilibrium confined and unconfined compressive stress upon strain, respectively (H

Measurement Of Fruit And Vegetable Intake Incorporating A Diversity, Equity, And Inclusion Lens. Comment On Di Noia, J.; Gellermann, W. Use Of The Spectroscopy-Based Veggie Meter® To Objectively Assess Fruit And Vegetable Intake In Low-Income Adults, Carmen Byker Shanks, Betty Izumi, Courtney A. Parks, Amy L. Yaroch

OHSU-PSU School of Public Health Faculty Publications and Presentations

Disparities in fruit and vegetable intake (FVI) and diet-related diseases exist among low-income and racial/ethnic minority populations [1,2,3,4]. Intervention approaches to eliminate FVI disparities frequently utilize dietary assessment to measure impact. Studies measure FVI in varying ways, but do not fully account for diversity, equity, and inclusion (DEI).

Enhancing Task Fmri Preprocessing Via Individualized Model-Based Filtering Of Intrinsic Activity Dynamics, Matthew F Singh, Anxu Wang, Michael Cole, Shinung Ching, Todd S Braver

2020-Current year OA Pubs

Brain responses recorded during fMRI are thought to reflect both rapid, stimulus-evoked activity and the propagation of spontaneous activity through brain networks. In the current work, we describe a method to improve the estimation of task-evoked brain activity by first "filtering-out the intrinsic propagation of pre-event activity from the BOLD signal. We do so using Mesoscale Individualized NeuroDynamic (MINDy; Singh et al. 2020b) models built from individualized resting-state data to subtract the propagation of spontaneous activity from the task-fMRI signal (MINDy-based Filtering). After filtering, time-series are analyzed using conventional techniques. Results demonstrate that this simple operation significantly improves the statistical …

Therapeutic Efficacy Of 177lu-Labeled A20fmdv2 Peptides Targeting Ανβ6, Truc Thao Huynh, Sreeja Sreekumar, Cedric Mpoy, Buck Edward Rogers

2020-Current year OA Pubs

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Relationships Between Correlated Spikes, Oxygen And Lfp In The Resting-State Primate, Jingfeng M Li, Benjamin T Acland, Alexander S Brenner, William J Bentley, Lawrence H Snyder

2020-Current year OA Pubs

Resting-state functional MRI (rsfMRI) provides a view of human brain organization based on correlation patterns of blood oxygen level dependent (BOLD) signals recorded across the whole brain. The neural basis of resting-state BOLD fluctuations and their correlation remains poorly understood. We simultaneously recorded oxygen level, spikes, and local field potential (LFP) at multiple sites in awake, resting monkeys. Following a spike, the average local oxygen and LFP voltage responses each resemble a task-driven BOLD response, with LFP preceding oxygen by 0.5 s. Between sites, features of the long-range correlation patterns of oxygen, LFP, and spikes are similar to features seen …

Autism: A Case Report, Sunitha Solomon-Calvin Ms., Anice George Dr.

Manipal Journal of Nursing and Health Sciences

Autism, otherwise identified under the DSM 5 Diagnostic and Statistical Classification as Autism Spectrum Disorder (ASD), is a neurodevelopmental genetic developmental disorder among children, which can affect the social communication, changes in sensory aspects and repetitive, ritualistic patterns of behaviour. The present report describes a case study of a child who was diagnosed with autism. The report follows the child’s history from birth till diagnosis and explores the challenges faced by the child and parents to obtain necessary care for the child during the current pandemic situation in an attempt to raise awareness regarding the condition among health professionals.

A Pilot Study Examining The Effect Of Dynamic Warm-Up Utilization On Rodeo Performance Of College Breakaway Ropers, Tyler Frank

International Journal of Exercise Science: Conference Proceedings

ABSTRACT

Pre-competition dynamic warm up participation has exemplified significant improvements in sport performance and decreased risk of injury for high velocity, high impact sports. Rodeo is recognized as a high velocity/intensity sports with great risk of impact and non-impact related injuries. However, no research has investigated the effect of pre-competition warm up utilization of the performance of rodeo athletes. PURPOSE: Therefore, the purpose of the current research examination was to evaluate the efficacy of per-competition dynamic warm up participation for rodeo athletes. METHODS: Seven collegiate rodeo females, competing as Breakaway Ropers, were selected at participants for the current …

Cortical Activity Measured With Low-Intensity Fatiguing Contractions Of The Quadriceps Muscle Group, Emma D. Bozarth, Lyric D. Richardson, Amy E. Riera, Micheal J. Luera, Amber H. Bozer

International Journal of Exercise Science: Conference Proceedings

Modulation of force production required during exercise is regulated from various mechanisms in the central and peripheral nervous system. Fatigue is influenced by various mechanics that may hinder the ability to continuously sustain force production. The neural activation patterns of these systems can be recorded as electrical impulses using several non-invasive techniques. The ability to examine these during fatiguing exercise has provided further insight into activation patterns in the central nervous system (i.e., motor and pre-motor cortex) during sustained muscle contractions. Electroencephalography (EEG) has been recently utilized to examine changes associated with central fatigue, but limited advancements in technology for …

Effects Of Low-Intensity Fatigue On Motor Unit Firing Properties During Maximal Voluntary Isometric Contractions, Lyric Richardson, Amy Riera, Emma Bozarth, Micheal Luera

International Journal of Exercise Science: Conference Proceedings

Rehabilitation from injuries impairing the neuromuscular system is often difficult to quantify due to task specificity of the affected or immobilized limb or limbs. Often, exercise regimens with clinical practitioners are designed to progress motor performance to a capacity that reflects muscle force production to pre-injury capacity. Modulation of force production from these tasks are regulated from various mechanism in the central and peripheral nervous system. The neural activation of these systems can be recorded as electrical impulses using several non-invasive techniques. Recently, the ability to examine these during fatiguing exercise has provided further insight into activation patterns and firing …

Associations Of Changes In Body Composition And Athletic Performance In Collegiate American Football Players, Jake Boykin, Dale Kieth, Christine Harrison, Javier A. Zaragoza, Jessica Prather, Matthias Tinnin, Lemuel W. Taylor Iv, Grant M. Tinsley

International Journal of Exercise Science: Conference Proceedings

Football practitioners ubiquitously employ offseason resistance training to improve on-field performance. Early offseason training is frequently designed to emphasize accretion of lean and total body mass. While this is a main objective of sport-specific conditioning, there are few investigations comparing correlated changes in body composition, maximal strength, and football-specific performance tests after an early-offseason training program. PURPOSE: The purpose of this analysis was to quantify the relationship between changes in athletic performance and body composition in collegiate American football players. METHODS: Before and after a 7-week offseason training program, body composition and athletic performance were assessed in NCAA Division III …

Relationship Between Changes In Upper Body Fat-Free Mass And Bench Press Performance In American Football Players, Dale S. Keith, Jake R. Boykin, Christine M. Harrison, Javier A. Zaragoza, Jessica Prather, Matthias Tinnin, Lem W. Taylor, Grant M. Tinsley

International Journal of Exercise Science: Conference Proceedings

Horizontal pushing strength and strength endurance are relevant attributes for blocking and block shedding in American football. Since most positions in American football require the ability to either block or shed a block, and since bench press repetitions to failure (RTF) with 225 pounds is a component of the NFL draft combine, improving horizontal pushing strength and strength endurance have been key areas of emphasis for strength and conditioning coaches working with these athletes. PURPOSE: The purpose of this analysis was to quantify the relationship between changes in upper body fat-free mass (FFM) and metrics of bench press performance …

Cardiorespiratory Coordination Among Intermediate And Novice Female Collegiate Rowers, Zoey Jackson, Michelle Etchebaster, Paula Gutiérrez, Gemma Hernández, Sergi G. Retortillo, Zacharias Papadakis

International Journal of Exercise Science: Conference Proceedings

Elite rowers present high levels of cardiorespiratory performance. Rowers’ on-water performance can be predicted by a cardiopulmonary exercise test (CPET) and related measured parameters such as maximum oxygen uptake test (VO2max), ventilation (VE), heart rate (HR), expired fraction of oxygen (FeO2) and carbon dioxide (FeCO2). However, such testing provides little information about the non-linear dynamic interactions during rowing and the qualitative synergetic reconfigurations between cardiovascular and respiratory systems to adjust to the individual rowing performance. Cardiorespiratory coordination (CRC) has been proposed as a method to measure the co-variation among cardiorespiratory variables during a CPET. PURPOSE: To measure and compare …

Exploring Physical Fitness Profile Of College Students Through Principal Component Analysis: A Case Study, Alejandra Rincon Cortes, Melissa Dorvily, Zoey Jackson, Michelle Etchebaster, Zacharias Papadakis

International Journal of Exercise Science: Conference Proceedings

Universities offer lifetime physical fitness (PF) courses and organize health fairs to keep their students physically fit. Despite these efforts, only 49.9% of US students meeting the National Guidelines for physical activity, reporting low fitness levels, as evaluated by the respective scores of the five fitness components. Fitness evaluation though is a time-consuming process and students’ time constrains have been postulated as reasons for lack of participation, motivation, and involvement. PURPOSE: Since time availability may influence students’ participation in a battery of fitness testing for evaluating their PF levels, this study aimed through principal component analysis (PCA) to reduce the …