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Articles 15361 - 15390 of 23770
Full-Text Articles in Medicine and Health Sciences
Taijiquan In The Prevention Of Symptoms Of Parkinson’S Disease – A Comparative Analysis Of Research Results, Malgorzata Kawa, Mateusz Kajnat, Krzysztof Klukowski
Taijiquan In The Prevention Of Symptoms Of Parkinson’S Disease – A Comparative Analysis Of Research Results, Malgorzata Kawa, Mateusz Kajnat, Krzysztof Klukowski
Baltic Journal of Health and Physical Activity
The primary symptom in Parkinson’s disease (PD) is a progressive disorder of motor functions. Despite constant pharmacological treatment, the patient’s daily functioning ability diminishes, leading to deterioration in the quality of life. Clinical and experimental studies show that systematic use of physical exercise delays the build-up of motor impairments in Parkinson’s disease by prolonging patients’ functional independence and thereby improving their quality of life. Systematic physical activity, such as resistance, balance, and stretching exercises (elements of aerobics, Nordic walking, dance, tai chi, or the use of Taijiquan martial arts), is considered as possibly useful therapy in symptomatic treatment of PD. …
Sensitivity To Pain And Strategies Of Coping With Stress In Combat Athletes, Katarzyna Leznicka, Anna Starkowska, Agnieszka Lulinska, Magdalena Kowalczyk
Sensitivity To Pain And Strategies Of Coping With Stress In Combat Athletes, Katarzyna Leznicka, Anna Starkowska, Agnieszka Lulinska, Magdalena Kowalczyk
Baltic Journal of Health and Physical Activity
The aim of the study was to assess the perception of pain (threshold and tolerance to pain of the combat athletes in comparison to those not practicing any sport and checking whether there is a correlation between the pain perception and strategies for coping with stress in both studied groups. The study was conducted on 273 healthy men. The test group consisted of 203 athletes; the control group consisted of 70 students from the Faculty of Physical Culture, University of Szczecin. The test of the threshold and pain tolerance was performed using an algometer manufactured by Quirumed Company. To assess …
Spatial Diversity Of The Activity Of Sports Clubs In Poland In 2016, Tomasz Michalski, Tomasz Wiskulski
Spatial Diversity Of The Activity Of Sports Clubs In Poland In 2016, Tomasz Michalski, Tomasz Wiskulski
Baltic Journal of Health and Physical Activity
The article is part of the current trend in publications showing the diversity of Poland at a local level. Its aim is to find regularities in spatial diversity of participation in and the offer of sport and recreation activity by sports clubs in Poland in 2016. The analysed data come from the Local Data Bank of the Central Statistical Office. Poviat (LAU 1) is the basic research unit. 5 variables were applied: persons practising sport per 1,000 population; the percentage of women among all practising; the percentage of persons under 18 years old among all practising, the number of sports …
Health Behaviors In Early Adulthood, Magdalena Weber-Rajek, Ewelina Lulinska-Kuklik, Agnieszka Radziminska, Waldemar Moska
Health Behaviors In Early Adulthood, Magdalena Weber-Rajek, Ewelina Lulinska-Kuklik, Agnieszka Radziminska, Waldemar Moska
Baltic Journal of Health and Physical Activity
During the early adulthood health promoting behaviors are created, but also risky behaviors increase. The research of health behavior is believed to be currently a valid method for estimating the health status of the population. The purpose of the research was to evaluate the health behaviors of young adults studying at various courses in Bydgoszcz universities. The study involved 313 people studying in the fields of health and engineering. The study used the Inventory of Health Behaviors (IoHB) by Z. Juczynski. Throughout the treatment group an average level of health-related behavior was shown. The highest level of health-related behavior has …
The Importance Of The Type Of Sport And Life Experience In The Dual Career In Elite Sport Based On The Analysis Of Poland, Marek Graczyk, Paul I. Wylleman, Anna Nawrocka, Pawel A. Atroszko, Waldemar Moska, Tomasz Tomiak, Hubert Krzysztofiak
The Importance Of The Type Of Sport And Life Experience In The Dual Career In Elite Sport Based On The Analysis Of Poland, Marek Graczyk, Paul I. Wylleman, Anna Nawrocka, Pawel A. Atroszko, Waldemar Moska, Tomasz Tomiak, Hubert Krzysztofiak
Baltic Journal of Health and Physical Activity
The objective of this study is to check whether the type of sport is important for the development of the dual career in professional sport. This study utilised the Chi-square test of the independence measurement model and student’s T test. It also analysed 7 scenarios. A final survey-list consisted of the 38 items of competences and it was completed by 243 young people who took part in this study; the sample included 151 (67.7%) athletes training individual disciplines and 72 (32.3%) team disciplines. The statistically significant results between the groups are in terms of competence (scenarios 3 and 6). There …
Diversity Of Factors Determining Physical Activity In Youth In Visegrad Countries, Ewelina Niznikowska, Jozef Bergier, Barbara Bergier, Pongrac Acs, Jan Junger, Ferdinand Salonna
Diversity Of Factors Determining Physical Activity In Youth In Visegrad Countries, Ewelina Niznikowska, Jozef Bergier, Barbara Bergier, Pongrac Acs, Jan Junger, Ferdinand Salonna
Baltic Journal of Health and Physical Activity
The present study aimed to gain knowledge about the diversity of factors determining physical activity in youth from the V4 countries. The study involved 2145 students aged 15-17 years from the Visegrad countries (V4): the Czech Republic, Slovakia, Hungary and Poland. A diagnostic survey was used as the research method in the form of the International Physical Activity Questionnaire (IPAQ-L). The Kruskall-Wallis and Mann-Whitney U tests as well as the Pearson Chi-square independence test were applied to do the statistical calculations and determine statistically significant relationships. More than half of the surveyed youth from the V4 countries (58.2%) demonstrated a …
Physical Activity And Sport As A Protective Factor Against Health--Threatening Experiments With Adulthood, Magdalena Jochimek, Daniel Krokosz, Mariusz Lipowski
Physical Activity And Sport As A Protective Factor Against Health--Threatening Experiments With Adulthood, Magdalena Jochimek, Daniel Krokosz, Mariusz Lipowski
Baltic Journal of Health and Physical Activity
The aim of this paper is to specify to what extent goal orientation in physical activity and sports constitutes a protective factor against involvement in risky behaviors. The research group consisted of 430 eighteen-year-old high school students (females n = 203; males n = 227; athletes n = 137; physically active n = 198; inactive group n = 95). Subjects were asked to complete a „pen-and-paper” task of filling-in the IPAO Lipowski & Zaleski (2015) and a questionnaire concerning involvement in risky behaviors. Male athletes high scores in persistence in action dimension were reflected by a lower likelihood of cigarette …
Physical Activity Levels Of Rural And Urban Seniors In The Region Of Warmia And Mazury In Poland, Aneta Omelan, Robert Podstawski, Bogdan Wziatek, Rafael Merino-Marbán, Oscar Romero-Ramos
Physical Activity Levels Of Rural And Urban Seniors In The Region Of Warmia And Mazury In Poland, Aneta Omelan, Robert Podstawski, Bogdan Wziatek, Rafael Merino-Marbán, Oscar Romero-Ramos
Baltic Journal of Health and Physical Activity
A sedentary lifestyle may lead to infirmity or disability. This study was undertaken to evaluate the physical activity (PA) levels of rural and urban seniors (60+) in Poland. The study was conducted on 274 seniors (60+, 146 urban dwellers, 128 rural dwellers). An interview questionnaire was used to collect data. The results were analyzed statistically using descriptive statistics, and a significance test was applied to determine differences between the two subpopulations (α = 0.05). Urban seniors had significantly (p = 0.0007) higher PA levels than rural seniors. The majority of physically active seniors did not meet the World Health Organization’s …
The Effect Of The Cluster Randomized Hippa Intervention On Childcare Children’S Overall Physical Activity, Marjo Anette Mehtala, Arja Saakslahti, Anne Soini, Tuija Tammelin, Janne Kulmala, Jari Villberg, Kari Nissinen, Marita Poskiparta
The Effect Of The Cluster Randomized Hippa Intervention On Childcare Children’S Overall Physical Activity, Marjo Anette Mehtala, Arja Saakslahti, Anne Soini, Tuija Tammelin, Janne Kulmala, Jari Villberg, Kari Nissinen, Marita Poskiparta
Baltic Journal of Health and Physical Activity
The effect of the cluster randomized Home- and childcare-based Intervention to Promote Physical Activity (HIPPA) intervention on the everyday physical activity (PA) of children between the ages of 4 to 5 years was evaluated. Fourteen childcare centers with 102 children born in 2007 and their families participated in the study. HIPPA was implemented over a single preschool year in seven childcare centers while seven other centers continued their normal care (control group, CG). The PA levels of children were assessed by accelerometers six times every six months during two and a half years of research. Valid PA data were obtained …
Effects Of Court-Specific And Minimalist Footwear On Patellar Tendon Loading During A Maximal Change Of Direction Task, Jonathan Sinclair, Paul John Taylor
Effects Of Court-Specific And Minimalist Footwear On Patellar Tendon Loading During A Maximal Change Of Direction Task, Jonathan Sinclair, Paul John Taylor
Baltic Journal of Health and Physical Activity
The aim of the current investigation was to examine the effects of court shoes, minimalist, energy return and athletic footwear on the loads experienced by the patellar tendon during a maximal change of direction task. Ten male participants performed maximal change of direction movements in court shoes, minimalist, energy return and athletic footwear. Lower limb kinematics were collected using an 8-camera motion capture system; ground reaction forces were quantified using an embedded force platform. Patellar tendon kinetics were examined via a musculoskeletal modelling approach, and the frictional properties of the footwear were examined using ground reaction force information. The results …
Challenges Of Female Vault Finals For The 2008–2016 Period, Suncica Delas Kalinski, Almir Atikovic, Igor Jelaska
Challenges Of Female Vault Finals For The 2008–2016 Period, Suncica Delas Kalinski, Almir Atikovic, Igor Jelaska
Baltic Journal of Health and Physical Activity
Women’s Artistic Gymnastics (WAG) competitions are determined by the rules of the Code of Points (CoP) which experience changes in each new Olympic Games (OG). One of the WAG CoP rules states that in the Vault Finals, gymnasts need to perform two different vaults. The aim of this study was to determine the quality of the vault performances and the differences between them during Vault Finals at all major competitions held from 2008 to 2016. Numerically higher values of Difficulty Scores, Execution Scores and Final Scores of the first vault compared to the scores of the second vault have been …
Effects Of 6-Week Basketball Training Using The Modified Circuit Weight Method, Jaroslaw Omorczyk, Tadeusz Ambroży, Ewa Puszczalowska-Lizis, Mateusz Nowak, Andrzej Markowski
Effects Of 6-Week Basketball Training Using The Modified Circuit Weight Method, Jaroslaw Omorczyk, Tadeusz Ambroży, Ewa Puszczalowska-Lizis, Mateusz Nowak, Andrzej Markowski
Baltic Journal of Health and Physical Activity
The study aim was to evaluate the effect of a 6-week modified workout routine using the modified circuit weight method on selected anthropometric measures, components of physical fitness and physiological indices in competitive basketball players. The study involved 30 basketball players (mean age: 23.4 ±1.8 years). Modified circuit weight method sessions were repeated 3 times a week. Each training session was subdivided into 3 circuits: strength conditioning, exercises to enhance functional fitness and a circuit of sport-specific exercises. Statistically significant differences in values of circumferences and skinfolds were found between pre-test and post-test values, with no statistically significant changes in …
The Diagnostic Value Of Attributes From An Optimum Set Of Variables For Explaining An Outcome In Powerlifting At The Junior Level, Lukasz Plociennik, Igor Rygula, Tomasz Dancewicz, Krzysztof Łukaszuk
The Diagnostic Value Of Attributes From An Optimum Set Of Variables For Explaining An Outcome In Powerlifting At The Junior Level, Lukasz Plociennik, Igor Rygula, Tomasz Dancewicz, Krzysztof Łukaszuk
Baltic Journal of Health and Physical Activity
The sport of powerlifting has been extensively studied, but there is lack of information on an optimum list of features that explain performance in 19–20-years-old contestants. Therefore, the study aimed at two research objectives: (1) to determine a minimum set of attributes contributing the most information to an outcome; (2) to develop a biometric model describing the sport result. The study group (n = 30) consisted of athletes (aged 19.38 ±0.84) competing in powerlifting. Two methods for collecting information were used: observation and a diagnostic survey. Analytical methods comprised the multiple regression and Hellwig’s method. An analysis revealed that the …
Fundamental Movement Skills Of Six- To Seven-Year-Old Children In The First Grade Of Elementary School: A Pilot Study, Marcin Korbecki, Sara Wawrzyniak, Andrzej Rokita
Fundamental Movement Skills Of Six- To Seven-Year-Old Children In The First Grade Of Elementary School: A Pilot Study, Marcin Korbecki, Sara Wawrzyniak, Andrzej Rokita
Baltic Journal of Health and Physical Activity
The aim of the study was to determine fundamental movement skills of elementary school first-graders and to seek whether fundamental movement skills correlate with the pupils’ age and gender. The study involved students in the first grade of elementary school in Krosno. The study was conducted at the beginning of the 2015/2016 school year. A total of 98 pupils (43 girls and 55 boys) aged six and seven were tested, using the Test of Gross Motor Development – 2nd Edition. The study showed that the results of fundamental movement skills depend on the children’s age and gender. Older girls achieved …
Training-Related Modulations Of The Respiratory Hypoxic And Hypercapnic Response Sensitivity In Young Elite Endurance Athletes, Tomasz Tomiak, Olena Lusenko, Viktor Mishchenko
Training-Related Modulations Of The Respiratory Hypoxic And Hypercapnic Response Sensitivity In Young Elite Endurance Athletes, Tomasz Tomiak, Olena Lusenko, Viktor Mishchenko
Baltic Journal of Health and Physical Activity
The present study was performed to clarify of training-related modulations of the cardiopulmonary system (CPS) response sensitivity to a hypoxic and hypercapnia stimulus in young endurance athletes. The practical objective was to estimate a possible association between the reduction in sensitivity to respiratory homeostasis shifts and young athletes’ early sports specialization. Twenty-eight young male athletes aged 12.4–17.5 years with experience of strenuous endurance training in kayaking served as the subjects. The impact of strenuous endurance training was estimated in three parts of studies with athletes divided into age groups. Studies have demonstrated that endurance training in kayaking results in a …
Medical School Watercooler Newsletter - March 23, 2022, Lindsey Lyle
Medical School Watercooler Newsletter - March 23, 2022, Lindsey Lyle
Watercooler Newsletter
This is the March 23, 2022 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.
Contents include:
- MAA Reunion to include tour of College of Medicine
- Meet A Med Student: Victoria Antonello
- USA College of Medicine joins AAMC initiative to advance diversity, equity and inclusion
- Del Pozo-Yauner presents amyloidosis research at international meeting
- University Hospital approved for additional operating rooms
- Distinguished Scientist Seminar set for March 24
2022-03-23_Michigandaily_Covidmap, Michigan Department Of Health & Human Services
2022-03-23_Michigandaily_Covidmap, Michigan Department Of Health & Human Services
Daily Michigan COVID-19 Update
The "WHERE WE STAND WITH COVID-19" map was obtained from Michigan's main COVID-19 page: https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily at 3p.m., Monday - Saturday.
The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled.
The image contained a map, indicating total cases by county, and also provides statistics on Total Confirmed Cases, Total COVID-19 Deaths, Daily Confirmed Cases, and Daily COVID-19 Deaths. There …
2022-03-23 Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services
2022-03-23 Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services
Michigan COVID-19 Hospital Data
Contains the tables Statewide Hospital Capacity Report for COVID-19, COVID-19 Metrics, Statewide Hospital Available PPE Tracking for COVID-19, as well as the tables PPE Days On Hand and Patient Census.
Coronavirus Update 3-23-22, The Coronavirus Planning Team
Coronavirus Update 3-23-22, The Coronavirus Planning Team
University Briefings & Virtual Events
There will be a booster clinic on campus this coming Saturday, March 26, from 10 a.m. to 2 p.m. in the Edgerton Center atrium. The clinic will be open to SHU community members and their family and friends.
2022-03-23_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services
2022-03-23_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services
Cumulative Michigan COVID-19 Data
The COVID Overview page was obtained from Michigan's main COVID-19 page: https:/www.michigan.gov/coronavirus/0,9753,7-406-98163-520743--,00.html.
The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled. COVID case and testing data will be posted three times a week on Mondays, Wednesdays and Fridays.
This report is provisional and subject to change. City of Detroit and Wayne County are reported separately. MDHHS began tracking probable cases April 5, 2020. FCI indicates federal correctional institute. MDOC indicates Michigan Department of Corrections. Diagnostic tests, including nucleic acid amplification/real-time …
Temperature Changes During Implant Osteotomy Preparations In Fresh Human Cadaver Tibiae, Comparing Straight With Tapered Drills, Nikolaos Soldatos, Laura Nelson-Rabe, Nathan Palanker, Nikola Angelov, Georgios Romanos, Robin Weltman
Temperature Changes During Implant Osteotomy Preparations In Fresh Human Cadaver Tibiae, Comparing Straight With Tapered Drills, Nikolaos Soldatos, Laura Nelson-Rabe, Nathan Palanker, Nikola Angelov, Georgios Romanos, Robin Weltman
Faculty, Staff and Student Publications
The success of osseointegration depends on many factors. With temperatures beyond a 47 °C threshold over 1 min, bone survival may be impaired. The purpose of the study was to evaluate, in fresh human cadaver tibiae, the temperature changes during osteotomy preparations using two straight and two tapered implant systems' drills, external irrigation, and varying revolutions per minute (RPM). The tibiae from a fresh female cadaver were harvested bilaterally. Two tapered and two straight design drills were assessed. Two-hundred and forty osteotomies were prepared at 6 mm depth following the drill sequence of the manufacturers' protocol for each drilling speed. …
Accountability As A Key Virtue In Mental Health And Human Flourishing, John R. Peteet, Charlotte Vanoyen-Witvliet, C. Stephen Evans
Accountability As A Key Virtue In Mental Health And Human Flourishing, John R. Peteet, Charlotte Vanoyen-Witvliet, C. Stephen Evans
Faculty Publications
We propose that accountability plays an implicit, important, and relatively unexamined role in psychiatry. People generally think of accountability as a relation in which one party is held accountable by another. In this paper, we examine accountability as a virtue, drawing on philosophy, psychiatry, and psychology to examine what it means to welcome being accountable in an excellent way that promotes flourishing. When people manifest accountability as a virtue, they are both responsive to others they owe a response, and they are responsible for their attitudes and actions in light of these relationships. Psychiatric treatment often aims to correct disordered …
Accountability And Autonomy, Motivation, And Psychiatric Treatment, John R. Peteet, Charlotte Vanoyen-Witvliet, C. Stephen Evans
Accountability And Autonomy, Motivation, And Psychiatric Treatment, John R. Peteet, Charlotte Vanoyen-Witvliet, C. Stephen Evans
Faculty Publications
No abstract provided.
Implicit Bias Training In Student Registered Nurse Anesthetists, Iteona Roundtree, Bsn, Rn, Srna, Jodi-Ann Smith, Bsn, Rn, Srna
Implicit Bias Training In Student Registered Nurse Anesthetists, Iteona Roundtree, Bsn, Rn, Srna, Jodi-Ann Smith, Bsn, Rn, Srna
College of Nursing Posters
Research Question:
In first-year DNP student registered nurse anesthetists (SRNAs), will an implicit bias training activity increase self-awareness and knowledge of implicit bias and its implications in healthcare?
Dissecting Mutational Allosteric Effects In Alkaline Phosphatases Associated With Different Hypophosphatasia Phenotypes: An Integrative Computational Investigation, Fei Xiao, Ziyun Zhou, Xingyu Song, Mi Gan, Jie Long, Gennady M. Verkhivker, Guang Hu
Dissecting Mutational Allosteric Effects In Alkaline Phosphatases Associated With Different Hypophosphatasia Phenotypes: An Integrative Computational Investigation, Fei Xiao, Ziyun Zhou, Xingyu Song, Mi Gan, Jie Long, Gennady M. Verkhivker, Guang Hu
Mathematics, Physics, and Computer Science Faculty Articles and Research
Hypophosphatasia (HPP) is a rare inherited disorder characterized by defective bone mineralization and is highly variable in its clinical phenotype. The disease occurs due to various loss-of-function mutations in ALPL, the gene encoding tissue-nonspecific alkaline phosphatase (TNSALP). In this work, a data-driven and biophysics-based approach is proposed for the large-scale analysis of ALPL mutations-from nonpathogenic to severe HPPs. By using a pipeline of synergistic approaches including sequence-structure analysis, network modeling, elastic network models and atomistic simulations, we characterized allosteric signatures and effects of the ALPL mutations on protein dynamics and function. Statistical analysis of molecular features computed for the …
Seroprevalence Of Severe Acute Respiratory Syndrome Coronavirus-2 (Sars-Cov-2) Among Healthcare Providers Prior To The Vaccine Era In An Integrated Midwestern Healthcare System, Elie A. Saade, Xiaochun Zhang, Jaime H. Noguez, Lisa M. Stempak, Daniel Tisch, Christine Schmotzer, Robert A. Salata
Seroprevalence Of Severe Acute Respiratory Syndrome Coronavirus-2 (Sars-Cov-2) Among Healthcare Providers Prior To The Vaccine Era In An Integrated Midwestern Healthcare System, Elie A. Saade, Xiaochun Zhang, Jaime H. Noguez, Lisa M. Stempak, Daniel Tisch, Christine Schmotzer, Robert A. Salata
Faculty Scholarship
We performed severe acute respiratory coronavirus virus 2 (SARS-CoV-2) antinucleocapsid IgG testing on 5,557 healthcare providers and found a seroprevalence of 3.9%. African Americans were more likely to test positive than Whites, and HCWs with household exposure and those working on COVID-19 cohorting units were more likely to test positive than their peers.
Return To School After Anterior Cruciate Ligament Reconstruction: A Prospective Study Of Adolescents And Young Adults., Joseph Brutico, Ryan W. Paul, Margaret Wright, Steven Cohen, Michael G. Ciccotti, Christopher C Dodson, Kevin Freedman, Sommer Hammoud
Return To School After Anterior Cruciate Ligament Reconstruction: A Prospective Study Of Adolescents And Young Adults., Joseph Brutico, Ryan W. Paul, Margaret Wright, Steven Cohen, Michael G. Ciccotti, Christopher C Dodson, Kevin Freedman, Sommer Hammoud
Rothman Institute Papers
Background: The ability to return to school after orthopaedic surgery is an important consideration for young patients, as there is substantial literature indicating that school attendance is correlated strongly with academic performance.
Purpose: To evaluate the time to return to school, the barriers that students encounter when returning to school, and the academic effect of anterior cruciate ligament reconstruction (ACLR) in high school (HS) and college students.
Study design: Cohort study; Level of evidence, 2.
Methods: Full-time HS and college/graduate school (C/GS) students who underwent ACLR during the 2017 to 2018 and 2018 to 2019 academic periods were included in …
Perception Is Everything: Implementation Of A Peer Evaluation Program For Nurse Leaders In A Hospital Setting, Teruko Williams
Perception Is Everything: Implementation Of A Peer Evaluation Program For Nurse Leaders In A Hospital Setting, Teruko Williams
Student Scholarly Projects
Practice Problem: A hospital in the Sacramento County area seeking the ANCC Pathway to Excellence Program® designation determined upon performing a gap analysis that Element of Performance 2.8, a peer evaluation program, was absent, thus creating a deficiency in the fulfillment of the requirements for the designation.
PICOT: The PICOT question that guided this project was: In nurse leaders (P) how does the development of a formal peer evaluation process (I) compared to no formal process (C), influence the performance outcome score of self-efficacy (O) over 8 weeks (T)?
Evidence: The evidence demonstrated that if a …
Micrornas In Leukemias: A Clinically Annotated Compendium, Aleksander Turk, George A Calin, Tanja Kunej
Micrornas In Leukemias: A Clinically Annotated Compendium, Aleksander Turk, George A Calin, Tanja Kunej
Faculty, Staff and Student Publications
Leukemias are a group of malignancies of the blood and bone marrow. Multiple types of leukemia are known, however reliable treatments have not been developed for most leukemia types. Furthermore, even relatively reliable treatments can result in relapses. MicroRNAs (miRNAs) are a class of short, noncoding RNAs responsible for epigenetic regulation of gene expression and have been proposed as a source of potential novel therapeutic targets for leukemias. In order to identify central miRNAs for leukemia, we conducted data synthesis using two databases: miRTarBase and DISNOR. A total of 137 unique miRNAs associated with 16 types of leukemia were retrieved …
Targeted Dual-Modal Pet/Spect-Nir Imaging: From Building Blocks And Construction Strategies To Applications, Syed Muhammad Usama, Sierra C Marker, Servando Hernandez Vargas, Solmaz Aghaamiri, Sukhen C Ghosh, Naruhiko Ikoma, Hop S Tran Cao, Martin J Schnermann, Ali Azhdarinia
Targeted Dual-Modal Pet/Spect-Nir Imaging: From Building Blocks And Construction Strategies To Applications, Syed Muhammad Usama, Sierra C Marker, Servando Hernandez Vargas, Solmaz Aghaamiri, Sukhen C Ghosh, Naruhiko Ikoma, Hop S Tran Cao, Martin J Schnermann, Ali Azhdarinia
Faculty, Staff and Student Publications
Molecular imaging is an emerging non-invasive method to qualitatively and quantitively visualize and characterize biological processes. Among the imaging modalities, PET/SPECT and near-infrared (NIR) imaging provide synergistic properties that result in deep tissue penetration and up to cell-level resolution. Dual-modal PET/SPECT-NIR agents are commonly combined with a targeting ligand (e.g., antibody or small molecule) to engage biomolecules overexpressed in cancer, thereby enabling selective multimodal visualization of primary and metastatic tumors. The use of such agents for (i) preoperative patient selection and surgical planning and (ii) intraoperative FGS could improve surgical workflow and patient outcomes. However, the development of targeted dual-modal …