Medicine and Health Sciences Commons^™

Anti-Tumor Activity Of Cetuximab Plus Avelumab In Non-Small Cell Lung Cancer Patients Involves Innate Immunity Activation: Findings From The Cave-Lung Trial, Carminia Maria Della Corte, Morena Fasano, Vincenza Ciaramella, Flora Cimmino, Robert Cardnell, Carl M Gay, Kavya Ramkumar, Lixia Diao, Raimondo Di Liello, Giuseppe Viscardi, Vincenzo Famiglietti, Davide Ciardiello, Giulia Martini, Stefania Napolitano, Concetta Tuccillo, Teresa Troiani, Erika Martinelli, Jing Wang, Lauren Byers, Floriana Morgillo, Fortunato Ciardiello

Faculty, Staff and Student Publications

BACKGROUND: We recently conducted Cetuximab-AVElumab-Lung (CAVE-Lung), a proof-of-concept, translational and clinical trial, to evaluate the combination of two IgG1 monoclonal antibodies (mAb): avelumab, an anti-PD-L1 drug, and cetuximab, an anti-epidermal growth factor receptor (EGFR) drug, as second- or third-line treatment in non-small cell lung cancer (NSCLC) patients. We have reported clinically relevant anti-tumor activity in 6/16 patients. Clinical benefit was accompanied by Natural Killer (NK) cell-mediated antibody-dependent cell cytotoxicity (ADCC). Among the 6 responding patients, 3 had progressed after initial response to a previous treatment with single agent anti-PD-1, nivolumab or pembrolizumab.

METHODS: We report long-term clinical follow-up and additional …

Efficacy And Safety Of Direct Oral Anticoagulants With And Without Aspirin: A Systematic Review And Meta-Analysis, Talal Almas, Adeena Musheer, Arooba Ejaz, Fahd Niaz Shaikh, Anousheh Awais Paracha, Fizza Raza, Maryam Sarwar Khan, Fahad Masood, Faiza Siddiqui, Muhammad Hasnain Mankani

Medical College Documents

Background: Various anticoagulant therapies are prescribed to patients under physicians' discretion and recently Direct Oral Anticoagulants(DOAC) have been under trials to evaluate their safety and efficacy. In addition to this, the regimen of DOACs and Aspirin is of keen interest as researchers continue to find an optimal regimen to treat blood clots in patients. This study is a systematic review and meta-analysis of randomized controlled trials and observational studies that asses the safety and efficacy of DOAC with and without Aspirin.
Methods: We queried MEDLINE and Cochrane CENTRAL from their inception to April 2021, for published and randomized controlled …

Gender Inequalities In Polish And International Sports Organisations, Zbigniew Dziubinski, Natalia Organista

Baltic Journal of Health and Physical Activity

Background: The aim of this article is to check whether gender inequalities occur in Polish sports organisations and what the scale of those inequalities is in comparison to international organisations. Other aims relate to verification whether there exists a policy to align these inequalities: provisions prohibiting discrimination due to gender, rules and regulations providing women with a specified number of seats in the crucial positions of the organisation and activity of women’s sports committees. Material/Methods: The study used methods characteristic of sociology, especially methods of examining official documents: on the one hand, information generated by other empirical data from official …

Methods To Encourage Healthy Eating In Children: Review Of Current Findings, Reda Moceviciene, Apolinaras Zaborskis

Baltic Journal of Health and Physical Activity

Background: Healthy eating, especially fruit and vegetable consumption, is a major contributor to the prevention of chronic non-communicable diseases. The multiple benefits of healthy food and nutrition in childhood and adolescence reinforce the need for studies encouraging young people to healthy nutrition. The present review increases understanding of what methods (interventions) should be performed to encourage healthy eating in children and adolescents. Material/Methods: A scientific literature review of Medline (Pubmed) database was performed, a total of 615 publications were found. Of these, only 15 papers were selected for the analysis. Results: The multi-component interventions (encouraging of fruit and vegetable consumption …

Acute Effects Of Light Exercise On Subjectively Experienced Well-Being: Benefits In Only Three Minutes, Attila Szabo, Zoltan Gaspar, Julia Abraham

Baltic Journal of Health and Physical Activity

Background: In the context of sedentary lifestyle as a major contemporary health issue, this study examined how an ultra brief exercise bout affects perceived subjective well-being. Material/Methods: Two studies were conducted. In the first study, young participants performed light exercises for 3-minutes. The second study replicated the first, but a sitting-quietly control group was also included to account for possible habituation or order effects. On a single item 10-point Likert scale, conceptualized as core affect, participants rated their well-being immediately before and after the exercise bouts and rest, respectively. Results: In both studies the exercise triggered statistically significant (p < .001) improvement in the perceived well-being (effect sizes (d) = .62 in Study I, and d = .75 in Study II), while no statistically significant change was noted in the control group. Conclusions: These findings are the first ever in the scholastic literature to demonstrate that only 3 minutes of light exercises could trigger subjective experience of improved well-being. The practical implication of these findings is that an instant boost in subjective feeling states can be achieved through very short, light, and undemanding exercises that could be repeated several times a day in different life settings.

Factors Affecting Recreational Activity Of Young People From Secondary Schools, Agnieszka Wartecka-Wazynska

Baltic Journal of Health and Physical Activity

Background: The paper discusses factors which determine young people’s recreational activity in their leisure time. Learning about the factors of recreational activity will support efficient promotion of active lifestyles, improvement in health condition and education of young people, and participation in different forms of recreation. Material/Methods: In order to conclude on the statistical significance of the relationships and the strength of correlation between the variables, the author used Pearson's chi-square test for independence and Cramer's V coefficient. The research hypothesis was tested at two levels: α = 0.01 (denoted in the paper as **) and α = 0.05 (denoted in …

Characteristics Of Technical-Tactical Preparation Of Russian Men’S Judo Representation During The Olympic Games In London In 2012, Marek Adam, Beata Wolska, Piotr Klimowicz, Miroslaw Smaruj

Baltic Journal of Health and Physical Activity

Background: The aim of the study was to determine the value of indices of tactical and technical preparation (PTT) of Russian judo athletes during the Olympic Games in London. The values of these indices may designate the direction of activity in the process of special preparation and in the search for factors to optimize training before the main competitions. Material/Methods: During the Olympic Games in London in 2012, Russian judo representatives fought 31 fights. A multiple analysis of video footage and graphic registration allowed marking 423 technical attacks (including 24 efficient attacks) of the representatives of Russia and 384 attacks …

Plantar Pressure Distribution In Ice Skates While Gliding And Standing Compared To Barefoot And Trainer Conditions, Andrew Greenhalgh, Faye Chatterly, Cheryl Blewitt, Jonathan Sinclair, Nachiappan Chockalingam

Baltic Journal of Health and Physical Activity

Background: The aim of this study was to identify whether there are differences between plantar pressure distributions experienced whilst wearing ice skates during ice-gliding, compared to standing whilst barefoot, wearing trainers and wearing ice skates. The results of this study aim to provide a greater understanding of the distribution of the pressure through the ice skate to the human musculoskeletal system. Material/Methods: Nine female participants were recruited for this study (age 36.6 years ± 15.3, mass 63.7kg ± 7.4 height 1.63m ± 4.1). Pressure applied to the plantar surface of the feet was recorded at 50Hz using an F-Scan sensor. …

Blood K+ Concentration Balance After Prolonged Submaximal Exercise – The Role Of Both Uptake And Excretion Processes, Anna Szczesna-Kaczmarek

Baltic Journal of Health and Physical Activity

Background: A contracting muscle is a source of the plasma K+ concentration increase during physical exercise. The flux of K+ from contracting skeletal muscle to blood is related to the frequency of cells action potential. The elevated blood [K+] may result in the heart rate irregularities and interferes with the way nerves send signals. But plasma increased [K+] recovers rapidly to normal if a regulating mechanism takes action. The aim of this study was to evaluate the participation of processes restoring the balance in blood [K+] after prolonged submaximal exercise. Material/Methods: Nineteen healthy, young, physically active men performed the 120-min …

The Effects Of Acute Beetroot Juice Ingestion On Upper And Lower Body Muscular Power During Weightlifting Exercise In Men, Grant Weiderman, Chandler Riley, Joanna Powell, Katie Price, Lauren Wideen, Andrew Fest, Justin Kim, Maya Hammer, Sean Karl, Isabella Lincoln, Noelle Seekamp-Hicks, Joshua Leow, Maddy Espinoza, Adam Pennell, Rachel Tan

Seaver College Research And Scholarly Achievement Symposium

Nitrate-rich beetroot juice (BR) supplementation improves movements with high-velocity and high-power muscle contractions which may be due to enhanced blood flow, oxygenation and contractile function in type II muscle fibers. The literature has focused predominantly on the effects of BR supplementation running and cycling performance, but its efficacy in resistance exercise, a modality that relies on type II muscle fibers, has limited data. Furthermore, it is unknown how supplementation strategies impact the physiological and ergogenic effects of BR during exercise. Therefore, the purpose of this study is to assess whether single or multi-day nitrate ingestion will improve performance and muscle …

The Effect Of Co-Ingesting Beetroot Juice And Vitamin C On Blood Pressure In Hispanic Women: A Literature Review And A Proposal, Mikela De La Flor, Maya Hammer, Noelle Seekamp-Hicks, Rachel Tan

Seaver College Research And Scholarly Achievement Symposium

Dietary nitrate supplementation is known for improving blood pressure through vasodilation and may favorably alter oral microbial populations related to cardiovascular health. Co-ingestion with vitamin C (VITC) may further potentiate these benefits but this remains unexplored. Additionally, this field has yet to examine the influence of sex and ethnicity, which is important given that physiological differences exist between populations. The purpose of this study is to assess the effects of combining dietary nitrate, in the form of beetroot juice, and VITC on blood pressure and the oral microbiome in women of Hispanic, African American, and American descent across multiple institutions. …

Developing A Dental Trauma-Anxiety Measure Comparing U.S. And International Care, Margaret Tajirian

Seaver College Research And Scholarly Achievement Symposium

Background

The aim of this study was to improve upon the Modified Dental Anxiety Scale (MDAS) by developing the empathy-based International-Modified Dental Anxiety Scale (I-MDAS). This measure was produced and utilized to compare the dental experiences and anxiety levels of international patients versus national patients in the United States.

Methods

The I-MDAS is composed of the International scale and the original MDAS scale. Of 465 participants, 41.3% comprised the national population and 58.7% comprised the international population. Information about demographics, past negative dental experiences, and current dental anxiety was collected.

Results

There was no significant difference in dental anxiety levels …

Pomegranate Extract Supplementation On Neuromuscular Performance During Resistance Exercise, Katie Price, Joanna Powell, Matthew Joyner, Adam Pennell, Rachel Tan

Seaver College Research And Scholarly Achievement Symposium

Dietary nitrate supplementation has been shown to improve skeletal muscle function during high-velocity and high-power contractions due to its high nitrate levels; however, there is limited data examining its potential in exercise requiring these movements, such as resistance exercise. Nitrate supplementation has been studied extensively as beetroot juice, but its poor taste severely limits its application. Pomegranate extract (POM) may be an alternative nitrate source due to its superior taste, high nitrate content, and additional antioxidants but has yet to be explored. The purpose of the present study is two-fold: 1) to determine the nitrate concentration in POM; and 2) …

The Effects Of Acute Beetroot Juice Ingestion On Upper And Lower Body Muscular Power During Weightlifting Exercise In Men., Sean Karl, Isabella Lincoln, Joanna Powell, Grant Weiderman, Katie Price, Lauren Wideen, Andrew Fest, Justin Kim, Maya Hammer, Noelle Seekamp-Hicks, Joshua Leow, Maddy Espinoza, Adam Pennell, Rachel Tan

Seaver College Research And Scholarly Achievement Symposium

Dietary nitrate supplementation, administered per beetroot juice (BR), has been shown to enhance performance while cycling and running. BR has enhanced skeletal muscle contraction and blood flow within type II fibers which are recruited during high-velocity and high-power contractions. However, it is unknown whether BR influences alternative forms of exercise, such as resistance exercise. The purpose of this study is to assess whether BR supplementation influences neuromuscular performance (muscle power and speed), and repetitions-to-failure in healthy, recreationally active men. In a double-blind, randomized crossover design, 14 males will be recruited to complete two 4-day supplementation periods in which they consume …

Isolation Of Oral Bacterial Dna For 16s Rrna Sequencing To Determine Nitrate-Sensitive Oral Microbiota Following Acute Beetroot Juice Supplementation, Luka Sharabidze, Leah Stiemsma, Courtney Merrill, Chandler Riley, Maya Hammer, Ryan Kenney, Alyssa Riley, Katie Price, Adam Pennell, Rachel Tan

Seaver College Research And Scholarly Achievement Symposium

Dietary nitrate (NO3-) supplementation, provided as beetroot juice, improves cardiovascular, cognitive, and contractile function by augmenting nitric oxide (NO) biosynthesis; however, the specific taxa responsible, and whether NO3- ingestion can promote a favorable microbial composition to produce NO is yet to be established. To determine whether acute NO3- supplementation is associated with specific microbial taxa in females, 15 healthy adult females consumed an acute dose of NO3--depleted beetroot juice (PL) and NO3--rich beetroot juice (BR). Bacterial DNA from the buccal cells were isolated for subsequent 16s DNA sequencing for preserved regions in their 16s rRNA gene. Concentrations were assessed with …

Perceptions And Practices Of Key Worker Stakeholder Groups In Hospital Animal- Assisted Intervention Programs On Occupational Benefits And Perceived Risks, Kathryn R. Dalton, William Altekruse, Peter Campbell, Kathy Ruble, Karen C. Carroll, Roland J. Thorpe Jr., Jacqueline Agnew, Meghan F. Davis

People and Animals: The International Journal of Research and Practice

Background: Animal-assisted intervention (AAI) programs, used widely for patient benefit, have increasingly been used for healthcare workers (HCW) to reduce occupational stress. However, there are barriers to these programs which limit their utilization, for both patients and HCW, specifically infectious disease concerns. The aim of the research project is to identify barriers and facilitators to AAI program use for healthcare worker benefit, and determine knowledge, beliefs, and practices regarding infectious disease risk and control policies, in order to understand the contextual parameters of program implementation.

Methods: We collected perceptions of key stakeholders involved with hospital AAI programs (HCW and AAI …

Questionnaire Of Sports Ethics – A Tool For Assessing Moral Behaviour In Sport, Artur Ziolkowski, Anna Strzalkowska, Wojciech Saklak, Barbara Zaranska, Iwona Bonislawska

Baltic Journal of Health and Physical Activity

Background: The concept of ethical codes describes and explains morality of modern sportspersons. Authors of the article constructed a tool for assessing methods of moral behaviour in sport on the basis of the concept of ethical codes. The aim of this work is to present a tool for assessing a profile of moral behaviour of people involved in sport (both competitors, coaches and sports activists). Material/Methods: The Questionnaire of Sports Ethics consists of 52 statements which are classified into 5 scales that correspond to specific ethical codes. Respondents assess to what extent a form of behaviour described in the questionnaire …

Mass Media And Professional Sport, Zbigniew Dziubinski, Krzysztof W. Jankowski, Michal Lenartowicz, Julia Murrmann, Piotr Rymarczyk

Baltic Journal of Health and Physical Activity

The goal of this paper is to show the relationship between the mass media and professional sport, with special focus on both the positive and negative impact the mass media might have on the development of sport, complete with changes which the mass media trigger in sport as such. In order to do so, the paper employs a range of theories, including the structural-functional theory, symbolic interactionism and, to a certain extent, the theory of social conflict. Several research methods have been used as well, including the inductive and deductive methods, the idiographic and nomothetic methods and an analysis of …

Proposal Of An Observation Sheet For Basketball Players’ Performance Assessment, Andrzej Szwarc, Izabela Lekner

Baltic Journal of Health and Physical Activity

Background: The aim of this study was to develop a research tool used for an assessment of basketball players’ performance. Material/Methods: First, research of the subject literature was made and a preliminary outline of an assessment sheet for basketball players was developed. Next, after causing test observation, the final model of the observation sheet was prepared, and its reliability was evaluated. To measure the inter-observer agreement three experts independently viewed the same game, where they had to assess different components of game performance using the newly developed instrument. The inter- and intra-observer agreement was calculated by means of the kappa-values. …

The Assessment Of The Quality Of Health Related Websites By Students Of Physical Education And Physiotherapy Using The Discern Instrument, Ida Laudanska-Krzeminska

Baltic Journal of Health and Physical Activity

Background: The purpose of the article is to characterise the assessment of the Internet sites by physical education and physiotherapy students using the DISCERN questionnaire. An attempt has also been made to indicate the determinants of the overall final assessment of individual health-related Internet sites from 2005 to 2009. Material/Methods: The survey was carried out in 2005 and 2009 among 376 physical education and physiotherapy students at the University School of Physical Education in Poznan. The students assessed five Polish health-related websites. They used the DISCERN questionnaire to rate the quality of health information and filled in the ME & …

Aerobic And Anaerobic Endurance Of Disabled Swimmers In Special Preparation Sub-Period, Rafal Szafraniec, Wojciech Seidel, Dawid Kruszyna, Anna Zurowska

Baltic Journal of Health and Physical Activity

Background: The purpose of the study was to investigate whether, in addition to an expected increase in anaerobic endurance, aerobic endurance of disabled swimmers would also improve in a special preparation sub-period. Furthermore, decision was made to examine whether the applied tests prove sufficiently sensitive for swimmers with disabilities as well. Material/Methods: The study included 12 disabled swimmers from a section of the Polish Sports Association for the Disabled “START” Wroclaw. Two standardized tests were used. The T-30 test was used to evaluate aerobic endurance and the 6x50 m test was applied to estimate anaerobic endurance. For all analyzed parameters …

Directions And Ways Of Executing Judo Throws During Judo Contests As A Control Criterion Of An Individual’S Training Versatility, Marek Adam, Radoslaw Laskowski, Miroslaw Smaruj

Baltic Journal of Health and Physical Activity

Background: Symmetry of movement actions in sport is considered as an element of versatility which enlarges an individual’s technical and tactical capacity. Asymmetry usually limits this capacity and may also lead to overstrains of one side of the body and cause an injury. The research is done on health aspects and practical improvement in sport contest. Up-to-date research on judo contest effectiveness has been aimed at the ability of throwing into various directions. There is no material and data as compared to the directions of throwing and effective directions of the opponent’s attack. The purpose of this research was to …

The Long Lasting Effects Of Whole Body Rotation Vibration In A Fitness Exercise Program On Flexibility And Motor Coordination In Young Females, Tomasz Tomiak, Maria Agnieszka Niewiadomska, Mariusz Zasada, Ludmila J. Melnik, Viktor S. Mishchenko, Stanislaw Sawczyn

Baltic Journal of Health and Physical Activity

Background: The aim of the study was to determine additional effects of 8 weeks’ whole body rotation vibration combined with a fitness exercise program of health-related training on chosen motor coordination abilities and flexibility in young females. Material/Methods: Thirty-seven young females aged 20-25 (students) voluntarily participated in the study. The training program included 24 training sessions which were performed over the course of 8 weeks (3 sessions a week) and was based on basic principles of health-related protocols. The program of sessions was performed by subjects of theexperimental group with a working whole body vibration platform (20 Hz), whereas those …

Ways To Improve The Professional Skills Of Kurash Coaches, Azamkhonov Ashrafkhonovich Oltinkhon

Eurasian Journal of Sport Science

Purpose: It consists in conducting a public survey of kurash coaches and parents of athletes from youth sports schools and pedagogical analysis of the results obtained.

Methods: Analysis of materials of scientific and methodological literature, pedagogical observation, pedagogical experiment, mathematical and statistical analysis, questionnaire analysis. Results: In order to make kurash more popular, it was determined that it is necessary to provide full information to parents about the importance of this sport for the health of young people, as well as to create all conditions for the preparation of methodological manuals, the organization of training based on innovative methods, as …

2022-03-25_Michigandaily_Covidmap, Michigan Department Of Health & Human Services

Daily Michigan COVID-19 Update

The "WHERE WE STAND WITH COVID-19" map was obtained from Michigan's main COVID-19 page: https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily at 3p.m., Monday - Saturday.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled.

The image contained a map, indicating total cases by county, and also provides statistics on Total Confirmed Cases, Total COVID-19 Deaths, Daily Confirmed Cases, and Daily COVID-19 Deaths. There …

2022-03-25_Michiganoverview_Covidvaccinestats, Michigan Department Of Health & Human Services

Michigan COVID-19 Vaccine Data

The COVID Vaccine Dashboard page was obtained from Michigan's main COVID-19 page: https://www.michigan.gov/coronavirus/0,9753,7-406-98178_103214-547150--,00.html.

First-dose tracker above is for entire Michigan Population. Coverage maps below are for age 5+.

Previously reported numbers of administered vaccine doses may change as new data are received. A possible lag in reporting vaccine doses will result in increases in numbers previously reported.

This report is created by the Michigan Department of Health and Human Services Division of Immunization from data reported to the Michigan Care Improvement Registry (MCIR).

The dashboard contained the tabs Vaccines Delivered, Delivery Trend, Primary Series Doses Administered, …

2022-03-25_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services

Cumulative Michigan COVID-19 Data

The COVID Overview page was obtained from Michigan's main COVID-19 page: https:/www.michigan.gov/coronavirus/0,9753,7-406-98163-520743--,00.html.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled. COVID case and testing data will be posted three times a week on Mondays, Wednesdays and Fridays.

This report is provisional and subject to change. City of Detroit and Wayne County are reported separately. MDHHS began tracking probable cases April 5, 2020. FCI indicates federal correctional institute. MDOC indicates Michigan Department of Corrections. Diagnostic tests, including nucleic acid amplification/real-time …

2022-03-25 Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services

Michigan COVID-19 Hospital Data

Contains the tables Statewide Hospital Capacity Report for COVID-19, COVID-19 Metrics, Statewide Hospital Available PPE Tracking for COVID-19, as well as the tables PPE Days On Hand and Patient Census.

2022-04-25_Michiganoverview_Covidschooloutbreak, Michigan Department Of Health & Human Services

Michigan COVID-19 Outbreak Reports

The School Outbreak Data page was obtained from Michigan's COVID-19 data page: https://www.michigan.gov/coronavirus/stats/school-outbreak.

This report is created by the Michigan Department of Health & Human Services from data self-reported by local health departments. Data is updated every week.

K-12 School-Related Outbreak Reporting: In accordance with the Council of State and Territorial Epidemiologists' outbreak definition, a K-12 school-associated COVID-19 case (confirmed or probable) is defined as a student, teacher, or staff member physically present in the school setting or participated in a school sanctioned extracurricular activity within 14 days prior to illness onset (or a positive test result) OR …

2022-03-25_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated twice a week on Mondays and Thursdays.

Syndromic Surveillance System data is obtained from approximately 216 facilities participating in syndromic surveillance (139 Emergency Departments (ED), 77 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, …