Medicine and Health Sciences Commons^™

Age Estimation Using Ankle Radiographic Examination In A Contemporary Thai Population, Aekawit Triamkitsawat, Dittapong Songsaeng, Vijarn Vachirawongsakorn

Chulalongkorn Medical Journal

Background: Radiologic evaluation of skeletal maturity is one of the three practical methods to assess age in a living person. Objective: To assess the average age from the epiphyseal fusion of the distal tibia and fibula in Thai children and young adults. Methods: Ankle radiographs of 217 Thai patients aged 0 to 22 years who came to Siriraj Hospital from 1 January 2000 to 31 March 2020 were recruited for the study. The development of epiphyseal plate in the distal tibia and fibula was analyzed as a grading system. A composite score was also calculated. The relationship between age, the …

Evaluation Of Protective Efficacy Of Viral Vector Based Swine Influenza Vaccine And A Method For B Cell Culture For Monoclonal Antibody Generation, Sushmita Kumari

School of Veterinary and Biomedical Sciences: Dissertations, Theses, and Student Research

Influenza A virus of the swine (IAV-S) is an economically important swine pathogen that has the potential to spread to humans, thus posing an ongoing public health concern due to its zoonotic potential. Hemagglutinin (HA), the most abundant viral envelope protein, is known to be the key protective antigen. Anti-HA antibodies alone, have been shown to prevent IAV infection. In this study we evaluated the feasibility of a recombinant tri segmented Pichinde virus (PICV) as a viral vector to deliver IAV-S hemagglutinin antigen in pigs. Four groups of weaned pigs (T01-04) were immunized twice with PBS, rPICV-GFP as a vector …

Trend Analysis Of Physical Activity Measurement Research Using Text Mining In Big Data Analytics, Seungbak Lee, Minsoo Kang

International Journal of Physical Activity and Health

Measurements of physical activity taken in a valid and reliable way are essential in characterizing the relationship between physical activity and health outcomes. Given the steadily growing interest in the physical activity measurement and the lack of research to identify current trends, this study investigated the research trend of physical activity measurement by applying four text data mining techniques (i.e., future signal, keyword network analysis, keyword trend, and keyword association rule). A total of 54,670 publications from 1982 to 2021 were collected from PubMed. As a result, the current study 1) confirmed two weak signal topics (i.e., “validity of physical …

Reinforcement Sensitivity Theory Factors As Predictors Of Exercise Habits, Self-Efficacy, Social Support, And Affect, Alex C. Garn

International Journal of Physical Activity and Health

Objective: The study investigated contemporary reinforcement sensitivity theory (RST) personality factors as predictors of short-term changes in young adults’ exercise-related outcomes. Specifically, we explore RST factors as predictors of short-term changes in young adults’ reports of their exercise habits, exercise self-efficacy, exercise affect, and elicitation of exercise social support.

Design: Participants (N=406) completed surveys related to RST including four aspects of behavioral approach system, behavioral inhibition system, and fight-flight-freeze system as well as exercise habits, self-efficacy, affect, and social support at the beginning of one semester and took the same exercise survey six-weeks later.

Main Outcomes: Changes in …

The Effects Of Wearable Health Technology On Cancer Survivors’ Physical Activity, Sedentary Behavior, And Weight: A Meta-Analysis, Daphne Blount, Rui Zhang, Anne Blaes, Zan Gao

International Journal of Physical Activity and Health

Wearable health technology (WHT) has been suggested as a health intervention in preventing or reducing health risk factors in clinical populations. Cancer survivors exhibit risk factors prior to cancer diagnosis and acquire comorbidities as a result of their treatment. These conditions may increase likelihood of cancer recurrence and reduce quality of life by inhibiting survivors’ physiological function and predisposing them to other maladies. Several studies have suggested WHTs as an intervention in mitigating these risks. However, there lacks a comprehensive review of the current evidence to determine the efficacy of WHT interventions. Thus, a literature search of WHT studies within …

Rasch Analysis Of The Physical Activity Enjoyment Scale Among 9th- And 10th-Grade Students, Jane Shimon, Yong Gao

International Journal of Physical Activity and Health

Rasch Model analysis was used to evaluate construct validity and reliability of the Physical Activity Enjoyment Scale (PACES) in an adolescent population. A total of 349 9th and 10th graders (180 male; 169 female), aged 13 to 15 years (M = 14.13 SD = .793), completed the 18-item PACES scale at the conclusion of physical education classes. Responses to PACES items were analyzed using Rasch partial credit model. Of the 18 PACES items, five were identified as misfit items and were removed. The remaining 13 good-fit items (difficulty level ranged from -0.81 for Item #10 to 0.66 logits for Item …

Increase In 1rm Back Squat After Abdominal Stabilizing Maneuvers, Caro Els

All NMU Master's Theses

Increasing intra-abdominal pressure (IAP) during free weight exercises can protect the lumbar spine from excess movement; a cause of lower back pain. Abdominal bracing (AB) and abdominal hollowing (AH) are two stabilizing maneuvers that increase IAP. Previous literature primarily compared AH and AB in therapy settings on bodyweight single joint movements. The effect of AB and AH during a multi-joint movement involving a maximum or near maximum external load is unknown. The purpose of this study was to compare the effect of AB and AH on lower limb muscle activity and the maximum amount of external weight lifted during a …

Recruiting Vulnerable Populations Using Social Media: Implications For Nursing Research, Abbey Jo Klein, Alyson Hanish

Posters and Presentations: College of Nursing

No abstract provided.

Occupational Therapy Newsletter, Spring 2022, Occupational Therapy Department

News, Magazines and Reports

Letter from Department Chair and Program Director, Sharon McCloskey -- This academic year includes the 20th cohort attending -- The OT program remains fully accredited -- Letter from the newsletter editor, Carissa Scheier -- Dr. Jody Bortone, founding chair retires after 22 years -- Emma Bass receives Christine E. Bushar Award -- Dr. Jaimee Hegge receives the CHP Alumni Leadership Award -- Dr. Lola Halperin facilitates trainings on the use of play to foster development among children exposed to adversity -- Dr. Halperin also provided an online workshop Understanding Schizophrenia and Occupational Therapy for Individuals Affected by It, for the …

A Comprehensive Review On The Risk Of Metabolic Syndrome And Cardiovascular Disease After Liver Transplantation, Kashyap Chauhan, Adnan Khan, Salil Chowdhury, Heather Ross, Natali Salinas, Dina Halegoua-De Marzio

Division of Internal Medicine Faculty Papers & Presentations

Survival rates after liver transplantation have increased dramatically over the past 20 years. Cardiovascular disease is the most common extra-hepatic cause of mortality in the long-term post liver transplant. This is intimately linked with both the higher pre-existing rates of metabolic syndrome in these patients as well as increased propensity to develop de novo metabolic syndrome post-transplant. This unfavorable metabolic profile that contributes to cardiovascular disease is multifactorial and largely preventable. This review explores metabolic syndrome and cardiovascular disease and their contributory factors post liver transplantation to highlight areas for potential intervention and thus reduce the significant morbidity and mortality …

Patterns Of Crystallin Gene Expression In Differentiation State Specific Regions Of The Embryonic Chicken Lens, Zhiwei Ma, Daniel Chauss, Joshua Disatham, Xiaodong Jiao, Lisa Ann Brennan, A Sue Menko, Marc Kantorow, J Fielding Hejtmancik

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Purpose: Transition from lens epithelial cells to lens fiber cell is accompanied by numerous changes in gene expression critical for lens transparency. We identify expression patterns of highly prevalent genes including ubiquitous and enzyme crystallins in the embryonic day 13 chicken lens.

Methods: Embryonic day 13 chicken lenses were dissected into central epithelial cell (EC), equatorial epithelial cell (EQ), cortical fiber cell (FP), and nuclear fiber cell (FC) compartments. Total RNA was prepared, subjected to high-throughput unidirectional mRNA sequencing, analyzed, mapped to the chicken genome, and functionally grouped.

Results: A total of 77,097 gene-specific transcripts covering 17,450 genes were expressed, …

Generation Status, Ethnic Identity, Colonial Mentality, And Enculturation In Filipino Americans, Kamille Patricia Urmaza La Rosa

Dissertations

Filipino Americans’ psychological experiences pertaining to their generation status, ethnic identity, enculturation, and colonial mentality are rarely studied in counseling psychology due to inconsistent disaggregation of Asian American and Pacific Islander (AA&PI) data (Agbayani-Siewert, 2004; Espiritu, 2003; Nadal et al., 2010; Okamura, 2013). Literature suggests that the study of these constructs related to their mental health can guide more culturally informed care for this historically excluded population (David & Nadal, 2013; Nadal, 2020). The current study used an exploratory design to test six research hypotheses and accomplish the following: examine relationships between the constructs, investigate intergenerational differences, validate a measure …

Impact Of The Covid-19 Pandemic On The Malaria Control Program At The Epidemic Treatment Center Of Regional Hospital Of Kindia, Guinea, Mohamed Keita

Capstone Experience: Master of Public Health

The impact of infectious disease outbreaks and pandemics on the health systems could be alarming especially when there is an overlap in clinical manifestations of two infectious conditions. Despite the remarkable progress in reducing the burden of malaria in Africa since 2000, the COVID-19 pandemic has impacted the malaria control program. This paper describes the impact of the COVID- 19 pandemic on the health service delivery in Guinea and its consequences on malaria control programs before and during the COVID 19 pandemic. This paper aims to assess the impact of the COVID 19 pandemic on the malaria control program between …

Interrogating Race And Place-Based Inequities In Hiv And Covid-19, Rohan Khazanchi

EMET Projects

Over the last four years, I have developed a research focus examining the intersections of race, place, and health. My M.D. Honors Thesis reflects a snapshot of these efforts. In this collection of brief research reports, I leverage area-based measures to investigate structural inequities in three contexts: the HIV epidemic in our hyperlocal community, the early stages of the COVID-19 pandemic, and clinical trials for novel COVID-19 therapeutics. I apply novel social epidemiologic tools to measure and explore disparate outcomes. And, in reflecting upon my findings, I discuss concrete implications for clinicians, researchers, and policymakers alike.

Chapter 1: Neighborhood-Level Deprivation …

The Role Of Medical Language In Patient Care: Designing An Educational Session On The Use Of Non-Stigmatizing Language, Daniel Dooling

EMET Projects

No abstract provided.

Exploring Relationships Between Depression Self-Stigma And Trust In Primary Care Provider On Willingness To Seek Help, Tana Karenke

Dissertations (1934 -)

Depression is a mood disorder characterized by persistent feelings of sadness and/or loss of interest that effects an individual’s ability to carry out day-to-day activities. Depression can diminish one’s social functioning, interpersonal relationships, personal care, and work productivity. Despite the availability of various treatments for depression, roughly 34% of people suffering from depression symptoms do not seek treatment. Significant barriers for seeking help for depression symptoms include the stigma of mental illness and a lack of trust in healthcare providers; however, there is a paucity of research exploring the relationship between mental illness stigma and the role of trust in …

Predictors Of Hyperkalemia And Outcomes Of Dyskalemia In Us Veterans With Advanced Chronic Kidney Disease Transitioning To Dialysis, Ankur Dashputre

Theses and Dissertations (ETD)

Background: The kidneys play a crucial role in maintaining homeostasis of serum potassium levels (K+). Patients with advanced chronic kidney disease (CKD) are at a higher risk of experiencing dyskalemia events (i.e. hyper- and hypokalemia; especially the former) and thus future adverse outcomes. Currently, there is a dearth of literature on prediction models for hyperkalemia and the effects of dyskalemia on outcomes such as incidence of ischemic stroke and short-term hospital/emergency room (ER) utilization in an advanced CKD population transitioning to dialysis. Objectives: Using a nationally representative sample of US veterans with advanced CKD transitioning to dialysis, in the pre-dialysis …

Occupational Rights Workshops: Critical Reflection, Discussion, And Collaboration With Occupational Therapists, Michelle Arakaki

Student Capstone Papers

In the summer of 2020, occupational therapy organizations condemned systemic racism and called on the profession to improve its’ practices in promoting justice and enhancing efforts in increasing diversity, equity, and inclusion (DEI) (American Occupational Therapy Association, 2020; World Federation of Occupational Therapists). Since then, there have been formations of DEI committees, opportunities for continuing education in justice and antiracist practice, and more discussion in the literature on how therapists could support the occupational rights of their clients. Occupational rights are “the right of all people to engage in occupations that contribute positively to their well-being and the well-being of …

Supporting The Transition Out Of The Family Caregiver Role: An Occupation-Centered Approach, Whitney Wilbanks

Student Capstone Papers

Engagement in meaningful and valued occupations can be used as a means to help former family caregivers cope, heal, and grow following the loss of their loved one (Pickens, 2011). Occupational engagement can be used as a means to help former family caregivers reshape their personal identity, experience a sense of wholeness, and reestablish purpose and balance in their lives (Hocking, 2016). The purpose of this doctoral capstone project was to educate hospice care staff on ways to support individuals with transitioning out of the family caregiver role following the death of the care recipient. An educational resource was developed …

Genome-Wide Identification, Expression Pattern And Sequence Variation Analysis Of Snrk Family Genes In Barley, Jiangyan Xiong, Danyi Chen, Tingting Su, Qiufang Shen, Dezhi Wu, Guoping Zhang

Publications

Sucrose non-fermenting 1 (SNF1)-related protein kinase (SnRK) is a large family of protein kinases that play a significant role in plant stress responses. Although intensive studies have been conducted on SnRK members in some crops, little is known about the SnRK in barley. Using phylogenetic and conserved motif analyses, we discovered 46 SnRK members scattered across barley's 7 chromosomes and classified them into 3 sub-families. The gene structures of HvSnRKs showed the divergence among three subfamilies. Gene duplication and synteny analyses on the genomes of barley and rice revealed the evolutionary features of HvSnRKs. The promoter regions of HvSnRK family …

Remote Vascular Interventional Surgery Robotics: A Literature Review, Yang Zhao, Ziyang Mei, Xiaoxiao Luo, Jingsong Mao, Qingliang Zhao, Gang Liu, Dezhi Wu

Publications

Vascular interventional doctors are exposed to radiation hazards during surgery and endure high work intensity. Remote vascular interventional surgery robotics is a hot research field, in which researchers aim to not only protect the health of interventional doctors, but to also improve surgical accuracy and efficiency. However, the current vascular interventional robots have numerous shortcomings, such as poor haptic feedback, few compatible surgeries and instruments, and cumbersome maintenance and operational procedures. Nevertheless, vascular interventional surgery combined with robotics provides more cutting-edge directions, such as Internet remote surgery combined with 5G network technology and the application of artificial intelligence in surgical …

Utilizing Prams And Healthy People 2020 To Examine Black Women’S Breastfeeding Behavior In Louisiana Prior To The Onset Of The Covid-19 Pandemic, Almetra Amayá Granger

Electronic Theses and Dissertations

No abstract provided.

Conference Proceedings: Philippine Physical Therapy Association Convention 2021 Conference Abstracts. Philippine Physical Therapy Association National Convention- Impetus 2021 December 4, 2021

Philippine Journal of Physical Therapy

Conference Proceedings: Philippine Physical Therapy Association Convention 2021 Conference Abstracts. Philippine Physical Therapy Association National Convention- IMPETUS 2021 December 4, 2021.

International Approach Of Physical Activity And Health: Accomplishment And Challenges, Yuanlong Liu

International Journal of Physical Activity and Health

No abstract provided.

Gender-Specific Marketing Strategies Used By Sports Supplements: A Descriptive Study, Anna M. Cosgrove, Cori Lorts, Lynda B. Ransdell

International Journal of Physical Activity and Health

While the use of sports supplements is common among athletes and active adults, the marketing strategies used by these sports supplement manufacturers remain unknown—especially relative to active and athletic women. This descriptive study aims to describe marketing strategies used, such as color choices, structure function claims, and picture choice, and analyze if there are gender-specific differences within the strategies. A total of 100 best-selling sports supplements were selected from three separate third-party websites. Food products, accessories, and kitchen appliances were excluded. Supplement main webpages and sports supplement-specific webpages were explored to determine which marketing strategies were used and if there …

Path Associations Between Preservice Physical Educators’ Beliefs About Epistemology And Their Value And Self-Efficacy For Sport Education And Teaching Games For Understanding, Ken R. Lodewyk

International Journal of Physical Activity and Health

Teachers’ beliefs about epistemology – that is, their personal broad mental representations about the nature of reality, knowledge, and how people know and learn – have been associated with the many educational outcomes both in the classroom and in physical education. Little is known about whether these beliefs predict physical educators’ value (i.e., interest, importance, like, and usefulness) and self-efficacy (i.e., confidence in performing) for using constructivist teaching models such as sport education and teaching games for understanding. As a result, this study examined path associations from beliefs about epistemology (epistemic worldviews and epistemological beliefs) to value and self-efficacy for …

Development Of The Teacher Efficacy Toward Providing Physical Activity In The Classroom Scale, Erin E. Centeio, E. Whitney G. Moore, Jeanne Barcelona, Hayley B. Mckown, Heather E. Erwin, Alex C. Garn

International Journal of Physical Activity and Health

The overall aim for this study was to create and validate an instrument that helps researchers measure and better understand classroom teachers’ efficacy toward providing physical activity throughout the school day. The development of the Teacher Efficacy Toward Providing Physical Activity in the Classroom Scale (TETPPACS) occurred in two phases. First, in study one, after item development and face validity review, an exploratory factor analysis was conducted with pilot data (N = 320) to discover the factor structure of the TETPPACS. Second, with a follow-up sample (N = 192), a confirmatory factor analysis (CFA) was performed to confirm the factor …

The Scoop, Vol. 9 Issue 1, April 2022, Health Sciences Library

Volume 9

Latest news and updates from the Health Sciences Library in our monthly newsletter for April 2022.

2022 Spring Newsletter, Morehead State University. Nursing Department.

Nursing Department Publications Archive

2022 Spring Newsletter of the Department of Nursing at Morehead State University.

New Insights Into The Genetic Etiology Of Alzheimer's Disease And Related Dementias, Céline Bellenguez, Fahri Küçükali, Iris E Jansen, Luca Kleineidam, Sonia Moreno-Grau, Najaf Amin, Adam C Naj, Rafael Campos-Martin, Benjamin Grenier-Boley, Victor Andrade, Peter A Holmans, Anne Boland, Vincent Damotte, Sven J Van Der Lee, Marcos R Costa, Teemu Kuulasmaa, Qiong Yang, Itziar De Rojas, Joshua C Bis, Amber Yaqub, Ivana Prokic, Julien Chapuis, Shahzad Ahmad, Vilmantas Giedraitis, Dag Aarsland, Pablo Garcia-Gonzalez, Carla Abdelnour, Emilio Alarcón-Martín, Daniel Alcolea, Montserrat Alegret, Ignacio Alvarez, Victoria Álvarez, Nicola J Armstrong, Anthoula Tsolaki, Carmen Antúnez, Ildebrando Appollonio, Marina Arcaro, Silvana Archetti, Alfonso Arias Pastor, Beatrice Arosio, Lavinia Athanasiu, Henri Bailly, Nerisa Banaj, Miquel Baquero, Sandra Barral, Alexa Beiser, Ana Belén Pastor, Jennifer E Below, Penelope Benchek, Luisa Benussi, Claudine Berr, Céline Besse, Valentina Bessi, Giuliano Binetti, Alessandra Bizarro, Rafael Blesa, Mercè Boada, Eric Boerwinkle, Barbara Borroni, Silvia Boschi, Paola Bossù, Geir Bråthen, Jan Bressler, Catherine Bresner, Henry Brodaty, Keeley J Brookes, Luis Ignacio Brusco, Dolores Buiza-Rueda, Katharina Bûrger, Vanessa Burholt, William S Bush, Miguel Calero, Laura B Cantwell, Geneviève Chene, Jaeyoon Chung, Michael L Cuccaro, Ángel Carracedo, Roberta Cecchetti, Laura Cervera-Carles, Camille Charbonnier, Hung-Hsin Chen, Caterina Chillotti, Simona Ciccone, Jurgen A H R Claassen, Christopher Clark, Elisa Conti, Anaïs Corma-Gómez, Emanuele Costantini, Carlo Custodero, Delphine Daian, Maria Carolina Dalmasso, Antonio Daniele, Efthimios Dardiotis, Jean-François Dartigues, Peter Paul De Deyn, Katia De Paiva Lopes, Lot D De Witte, Stéphanie Debette, Jürgen Deckert, Teodoro Del Ser, Nicola Denning, Anita Destefano, Martin Dichgans, Janine Diehl-Schmid, Mónica Diez-Fairen, Paolo Dionigi Rossi, Srdjan Djurovic, Emmanuelle Duron, Emrah Düzel, Carole Dufouil, Gudny Eiriksdottir, Sebastiaan Engelborghs, Valentina Escott-Price, Ana Espinosa, Michael Ewers, Kelley M Faber, Tagliavini Fabrizio, Sune Fallgaard Nielsen, David W Fardo, Lucia Farotti, Chiara Fenoglio, Marta Fernández-Fuertes, Raffaele Ferrari, Catarina B Ferreira, Evelyn Ferri, Bertrand Fin, Peter Fischer, Tormod Fladby, Klaus Fließbach, Bernard Fongang, Myriam Fornage, Juan Fortea, Tatiana M Foroud, Silvia Fostinelli, Nick C Fox, Emlio Franco-Macías, María J Bullido, Ana Frank-García, Lutz Froelich, Brian Fulton-Howard, Daniela Galimberti, Jose Maria García-Alberca, Pablo García-González, Sebastian Garcia-Madrona, Guillermo Garcia-Ribas, Roberta Ghidoni, Ina Giegling, Giaccone Giorgio, Alison M Goate, Oliver Goldhardt, Duber Gomez-Fonseca, Antonio González-Pérez, Caroline Graff, Giulia Grande, Emma Green, Timo Grimmer, Edna Grünblatt, Michelle Grunin, Vilmundur Gudnason, Tamar Guetta-Baranes, Annakaisa Haapasalo, Georgios Hadjigeorgiou, Jonathan L Haines, Kara L Hamilton-Nelson, Harald Hampel, Olivier Hanon, John Hardy, Annette M Hartmann, Lucrezia Hausner, Janet Harwood, Stefanie Heilmann-Heimbach, Seppo Helisalmi, Michael T Heneka, Isabel Hernández, Martin J Herrmann, Per Hoffmann, Clive Holmes, Henne Holstege, Raquel Huerto Vilas, Marc Hulsman, Jack Humphrey, Geert Jan Biessels, Xueqiu Jian, Charlotte Johansson, Gyungah R Jun, Yuriko Kastumata, John Kauwe, Patrick G Kehoe, Lena Kilander, Anne Kinhult Ståhlbom, Miia Kivipelto, Anne Koivisto, Johannes Kornhuber, Mary H Kosmidis, Walter A Kukull, Pavel P Kuksa, Brian W Kunkle, Amanda B Kuzma, Carmen Lage, Erika J Laukka, Lenore Launer, Alessandra Lauria, Chien-Yueh Lee, Jenni Lehtisalo, Ondrej Lerch, Alberto Lleó, William Longstreth, Oscar Lopez, Adolfo Lopez De Munain, Seth Love, Malin Löwemark, Lauren Luckcuck, Kathryn L Lunetta, Yiyi Ma, Juan Macías, Catherine A Macleod, Wolfgang Maier, Francesca Mangialasche, Marco Spallazzi, Marta Marquié, Rachel Marshall, Eden R Martin, Angel Martín Montes, Carmen Martínez Rodríguez, Carlo Masullo, Richard Mayeux, Simon Mead, Patrizia Mecocci, Miguel Medina, Alun Meggy, Shima Mehrabian, Silvia Mendoza, Manuel Menéndez-González, Pablo Mir, Susanne Moebus, Merel Mol, Laura Molina-Porcel, Laura Montrreal, Laura Morelli, Fermin Moreno, Kevin Morgan, Thomas Mosley, Markus M Nöthen, Carolina Muchnik, Shubhabrata Mukherjee, Benedetta Nacmias, Tiia Ngandu, Gael Nicolas, Børge G Nordestgaard, Robert Olaso, Adelina Orellana, Michela Orsini, Gemma Ortega, Alessandro Padovani, Caffarra Paolo, Goran Papenberg, Lucilla Parnetti, Florence Pasquier, Pau Pastor, Gina Peloso, Alba Pérez-Cordón, Jordi Pérez-Tur, Pierre Pericard, Oliver Peters, Yolande A L Pijnenburg, Juan A Pineda, Gerard Piñol-Ripoll, Claudia Pisanu, Thomas Polak, Julius Popp, Danielle Posthuma, Josef Priller, Raquel Puerta, Olivier Quenez, Inés Quintela, Jesper Qvist Thomassen, Alberto Rábano, Innocenzo Rainero, Farid Rajabli, Inez Ramakers, Luis M Real, Marcel J T Reinders, Christiane Reitz, Dolly Reyes-Dumeyer, Perry Ridge, Steffi Riedel-Heller, Peter Riederer, Natalia Roberto, Eloy Rodriguez-Rodriguez, Arvid Rongve, Irene Rosas Allende, Maitée Rosende-Roca, Jose Luis Royo, Elisa Rubino, Dan Rujescu, María Eugenia Sáez, Paraskevi Sakka, Ingvild Saltvedt, Ángela Sanabria, María Bernal Sánchez-Arjona, Florentino Sanchez-Garcia, Pascual Sánchez Juan, Raquel Sánchez-Valle, Sigrid B Sando, Chloé Sarnowski, Claudia L Satizabal, Michela Scamosci, Nikolaos Scarmeas, Elio Scarpini, Philip Scheltens, Norbert Scherbaum, Martin Scherer, Matthias Schmid, Anja Schneider, Jonathan M Schott, Geir Selbæk, Davide Seripa, Manuel Serrano, Jin Sha, Alexey A Shadrin, Olivia Skrobot, Susan Slifer, Gijsje J L Snijders, Hilkka Soininen, Vincenzo Solfrizzi, Alina Solomon, Yeunjoo Song, Sandro Sorbi, Oscar Sotolongo-Grau, Gianfranco Spalletta, Annika Spottke, Alessio Squassina, Eystein Stordal, Juan Pablo Tartan, Lluís Tárraga, Niccolo Tesí, Anbupalam Thalamuthu, Tegos Thomas, Giuseppe Tosto, Latchezar Traykov, Lucio Tremolizzo, Anne Tybjærg-Hansen, Andre Uitterlinden, Abbe Ullgren, Ingun Ulstein, Sergi Valero, Otto Valladares, Christine Van Broeckhoven, Jeffery Vance, Badri N Vardarajan, Aad Van Der Lugt, Jasper Van Dongen, Jeroen Van Rooij, John Van Swieten, Rik Vandenberghe, Frans Verhey, Jean-Sébastien Vidal, Jonathan Vogelgsang, Martin Vyhnalek, Michael Wagner, David Wallon, Li-San Wang, Ruiqi Wang, Leonie Weinhold, Jens Wiltfang, Gill Windle, Bob Woods, Mary Yannakoulia, Habil Zare, Yi Zhao, Xiaoling Zhang, Congcong Zhu, Miren Zulaica, Lindsay A Farrer, Bruce M Psaty, Mohsen Ghanbari, Towfique Raj, Perminder Sachdev, Karen Mather, Frank Jessen, M Arfan Ikram, Alexandre De Mendonça, Jakub Hort, Magda Tsolaki, Margaret A Pericak-Vance, Philippe Amouyel, Julie Williams, Ruth Frikke-Schmidt, Jordi Clarimon, Jean-François Deleuze, Giacomina Rossi, Sudha Seshadri, Ole A Andreassen, Martin Ingelsson, Mikko Hiltunen, Kristel Sleegers, Gerard D Schellenberg, Cornelia M Van Duijn, Rebecca Sims, Wiesje M Van Der Flier, Agustín Ruiz, Alfredo Ramirez, Jean-Charles Lambert

Faculty, Staff and Student Publications

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly …