Medicine and Health Sciences Commons^™

Preventing Occupational Imbalance With Seniors Living In The Community During The Covid-19 Pandemic, Carrieanne Allegri

MOT Student Capstones

When COVID-19 shut down the world in March of 2020, nobody knew what to expect. What we discovered was seniors no longer had the opportunities to engage in social events, attend classes, or participate in the community. Understanding that engagement in leisure and social activities are important in preventing depression and isolation amongst seniors, finding alternative activities via virtual delivery and socially distanced were identified as a need. 3 An in-service was provided to senior citizens at a community center to address areas identified as a need by community center staff and members. The main objective of the in-service included …

Hk 710: Meta-Analysis, Minsoo Kang

GMAS Course Syllabi

No abstract provided.

Phad 795: Special Topics: Principles Of Statistical Mediation And Moderation, John P. Bentley Ph.D.

GMAS Course Syllabi

No abstract provided.

Predictive Factors In Nurse Retention: The Association Of Authentic Leadership, Nurse Leader Caring Behaviors, And Burnout In Novice Nurse Retention, April M. Novotny

PhD in Organizational Leadership

The demand for healthcare services in the United States is expected to dramatically increase in the coming decades. To meet the growing demand, a healthy workforce of nurses is necessary. In response to the identified problem of novice nurse retention, the researcher examined the concepts of authentic leadership, leadership caring behaviors, and burnout to determine the impact of these factors on intent to stay within an organization for novice nurses with less than 1 year of experience at a large community hospital. The study findings demonstrate a statistically significant correlation between the factors of authentic leadership, leader caring behaviors, burnout, …

Macomb Dental Society Journal Spring 2022

Journal of the Macomb Dental Society

In the Spring 2022 issue, the reader will find the following feature articles:

• Dedicated Dental Sportsman Club
• Resources to Support Antibiotic Stewardship in the Dental Office

Also included are regular columns from the President, Executive Director and Editor, as well as news shorts and information on upcoming events.

Regulatory Aspects Of Mild Cognitive Impairment: Toward A Harmonized Perspective, Peter J. Whitehouse

Faculty Scholarship

The development of the concept of mild cognitive impairment (MCI) and its practical application have been intimately tied to attempts to produce therapeutic agents. Understanding the regulatory environment and determining the way in which it can be influenced are critical to the development of drugs and their eventual approval. In this article, we review some of the current challenges surrounding the concept of MCI relevant to drug development, summarize activities in various regions of the world, and conclude with some suggested next steps and an alternative framing for approving drugs for MCI and related conditions.

Skin Cancer Biopsy And Detection Rates With Total Body Skin Examination: A Cross-Sectional Retrospective Analysis., Alexander Sherban, Shayan Waseh, Audra Hugo, Michael Bui, Constantine Daskalakis, Elizabeth Jones

Department of Dermatology and Cutaneous Biology Faculty Papers

Research Letter

Making Universal Digital Access Universal: Lessons From Covid-19 In Singapore, Irene Y. H. Ng, Sun Sun Lim, Natalie Pang

Research Collection College of Integrative Studies

Digital resources—which include devices, internet connection and digital literacy—have become basic needs. Thus with the global COVID-19 pandemic having accelerated digitalization, the urgency for universal digital inclusion has hastened. Otherwise, digital inequality will lead to social inequality and impede social mobility. Using Singapore as a case study, this article applies the insights learned from a participatory action research to recommend a policy framework for universal digital access, with practical humanistic steps towards full digital inclusion. Singapore is a digitally advanced nation with almost universal digital availability, yet when COVID-19 forced rapid digital adoption, gaps in access by vulnerable groups such …

An Examination Of Medical Resident Practices Regarding Patient Communication About Infant Safe Sleep Practices, Summer Samir Chahin

Dissertations

Infant mortality is a significant public health concern in the United States, particularly because of the large racial disparities in death rates. In particular, Black infants die at a rate twice that of white infants (Center for Disease Control, 2016). Sleep-related deaths are one of the most preventable causes of infant mortality. In Kalamazoo, Black and multi-racial infants account for the majority (3 out of 4) of sleep-related deaths (Sleep-Related Infant Deaths in Kalamazoo County Fact Sheet, 2017). To reduce sleep-related deaths, the American Academy of Pediatrics published recommendations for safe sleep practices (American Academy of Pediatrics, 2016).

Unfortunately, caregivers …

Evaluating Hospital Community Benefit And Community Health Improvement Requirements, Shelly Johnson

Dissertations

The Internal Revenue Service's (IRS) hospital community benefit standard aims to improve the community's health, it is a test the IRS uses to determine whether a hospital is organized and operated for the charitable purpose of promoting health. Participation in this program is required of all not-for-profit hospitals in the US, who spend billions of dollars annually in community benefit in place of taxes. Hospitals must annually submit IRS form 990 Schedule H and are required to report costs associated with their provision of community benefit spending. In addition, a hospital must conduct community health needs assessment (CHNA) and implementation …

Evalution Of A Quality Improvement Initiative To Utilize Glucose Gel For The Management Of Neonatal Hypoglycemia, Cassie Mccarthy

Doctor of Nursing Practice Scholarly Project

An Abstract of the Scholarly Project by

Cassie McCarthy

The purpose of this retrospective project is to assess the effectiveness of a completed quality improvement project via chart review. The project utilized glucose gel as a first line therapy for the management neonatal hypoglycemia in at-risk infants. Neonatal hypoglycemia is the most common metabolic abnormality and is associated with many undesirable side effects. Current treatment methods such as formula feeding and IV therapy are costly, invasive, and disruptive to family bonding. This study consisted of a retrospective chart review of a pre-glucose gel group, six months prior to the introduction …

Nursing News & Views - April 2022, Joanne Miller Rn

Nursing Newsletters

No abstract provided.

Discovering The Role Of Repeat Sequences In Regulation Of The Phaz Gene In Streptomyces Sp. Sfb5a, Harrison Senter, Stephen Baron

Honors Projects

Streptomyces sp. SFB5A is an actinomycete (filamentous bacterium) that degrades PHB using an extracellular PHB depolymerase. PHB depolymerase synthesis is induced by growth on PHB and repressed by glucose (or other preferred carbon sources)², which suggests that there is transcriptional regulation of its corresponding gene, phaZ. Binding sites are suspected to be the repeat sequences found in the phaZ gene. There are 3 different sets of primers that can be made in order to emphasize specific functional repeats while disrupting the functionality of others. The goal of the project is to transform Streptomyces sp. 5A with constructs …

Psychosocial Outcomes Of Orthopedic Injuries: An Analysis Of The Relationship Between The Athlete And The Athletic Trainer, Hannah Barnett

Honors Projects

An analysis on the impact of the level of social support from athletic trainers on the outcomes of orthopedic injuries in athletes. The foundational model for this research is Wiese-Bjornstal’s Integrated Model (1998). This model examines the effect of athletes’ emotional responses on their recovery. Social support from the athletic trainer can help mediate negative emotional responses and encourage positive emotional responses, which is why social support is crucial to recovery. Athletes with higher levels of perceived social support from their athletic trainers had more success with rehabilitation. This report consists of a review of the existing literature on psychosocial …

A Qualitative Inquiry Of The Interdisciplinary Engagement Of Teacher's And Therapist's Providing Virtual Services To Children With Disabilities, Giovanna Rossi

Transformations: Presentation Slides

In this research project, my goal was to determine if using the sensory-based equipment, used in Sensory Fit Families, as a bridge helped promote interdisciplinary discussions leading to a better or more effective service delivery model. I did this research through virtual interviews and transcribing the data. I examined teachers’ and therapists’ perceptions toward interdisciplinary collaboration when delivering online (virtual) instruction to preschool-aged children with disabilities. With this, I was able to triangulate key information on relevant content, activities, and feedback that focus on a unique collaboration between Physical Education teachers, Occupational Therapists, Physical Therapists, Speech Pathologists, and Special Education …

Blood Pressure Responses During Three Unweighted Conditions In A Lower Body Positive Pressure Treadmill, Danielle Toth, Madison Rees, Matthew Ballesteros, Bryanne N. Bellovary, James F. Hokanson, Erik Lind

Transformations: Presentation Slides

During exercise, lower leg muscle activation has been shown to increase venous return, exercise cardiac output, and arterial blood pressure (BP). Here we investigate BP at rest, with an increase in lower body pressure by unweighting volunteers in a lower body positive pressure treadmill (LBPP-TM). The purpose of this study was twofold; to determine if BP changes while standing over five-minute stages in response to four conditions. Nine participants (21.3±1.8 years) stood in a LBPP-TM in the following ordered conditions: 100%BWset (no unweighting, control), 70%BWset, 35%BWset, and 90%BWset (35%BWset is the greatest unweighted condition). A SunTech® automatic BP cuff measured …

Comparison Of Resting Heart Rates: Three Devices And Three Alter(Ed) Pressures, Matthew Ballesteros, Madison Rees, Danielle Toth, James F. Hokanson, Bryanne N. Bellovary

Transformations: Presentation Slides

Accurate heart rate (HR) measurements are key to exercise prescription. Many portable HR devices are available including the Apple watch. Resting HR from Apple series 3 watch were compared to measurements using a clinal grade Suntech Tango M2 (ST) and Vitalstream Caretaker (VS) pulse monitors. College-aged participants (N = 5) stood in the Alter G treadmill under positive pressures of 70%, 35%, and 90% body weight (BWset), respectively. Heart rates using each device were recorded at min 1, 3, and 5 for each condition. There were no significant differences in resting heart rates measured with the three devices. Average heart …

Living With Stuttering: Authenticity, Identity, And Mental Health, Sarah Musilli

Masters Theses

In an effort to manage stigma, some PWS attempt to conceal stuttering and pass as a fluent speaker (Constantino et al., 2017). These efforts to conceal may be counterintuitive, as concealment of stuttering is predictive of elevated distress (Gerlach et al., 2021) and decreased quality of life among PWS (Boyle et. al., 2018). Although this association exists, the factors explaining how and why it exists are unexplored. Identity conflict and feelings of in/authenticity are two potential factors that are explored in this study. Qualitative interviewing supplemented with quantitative survey data is utilized to explore the lived experiences of identity conflict …

Does Insomnia Increase The Risk Of Suicide In Hospitalized Patients With Major Depressive Disorder? A Nationwide Inpatient Analysis From 2006 To 2015, Zeeshan Mansuri, Abhishek Reddy, Ramu Vadukapuram, Mounica Thootkur, Chintan Trivedi

School of Medicine Publications

Introduction. nsomnia is an important symptom associated with major depressive disorder (MDD). In addition, it is one of the risk factors for suicide. Studies have shown the relationship be-tween insomnia and suicidal behavior in patients with MDD. However, this association has not been evaluated in a large sample of hospitalized patients.

Objectives. To evaluate the suicidal be-havior in MDD patients with insomnia compared to those without insomnia.

Methods. From the National Inpatient Sample (NIS 2006–2015) database using the ICD-9 code, patients’ data were obtained with the primary diagnosis of MDD and comorbid diagnosis of insomnia disorders (MDD+I). These patients were …

A Bayesian Spatiotemporal Model For Prevalence Estimation Of A Vre Outbreak In A Tertiary Care Hospital, A. Atkinson, B. Ellenberger, V. Piezzi, T. Kaspar, O. Endrich, A. B. Leichtle, M. Zwahlen, J. Marschall

2020-Current year OA Pubs

BACKGROUND: There was a nosocomial outbreak of vancomycin-resistant enterococci (VRE) at the hospital between 1

METHODS: A room-centric analysis of 12 floors (243 rooms) of the main hospital building was undertaken, including data on 37,558 patients over 22,072 person-weeks for the first 2 years of the outbreak (2018-2019). Poisson Bayesian hierarchical models were fitted to estimate prevalence per room and per week, including both spatial and temporal random effects terms.

RESULTS: Exploratory data analysis revealed significant variability in prevalence between departments and floors, along with sporadic spatial and temporal clustering during colonization 'flare-ups'. The oncology department experienced slightly higher prevalence …

Suppressing Fatty Acid Synthase By Type I Interferon And Chemical Inhibitors As A Broad Spectrum Anti-Viral Strategy Against Sars-Cov-2, Saba R. Aliyari, Xiaochao Wei, Clay F. Semenkovich, Et Al.

2020-Current year OA Pubs

SARS-CoV-2 is an emerging viral pathogen and a major global public health challenge since December of 2019, with limited effective treatments throughout the pandemic. As part of the innate immune response to viral infection, type I interferons (IFN-I) trigger a signaling cascade that culminates in the activation of hundreds of genes, known as interferon stimulated genes (ISGs), that collectively foster an antiviral state. We report here the identification of a group of type I interferon suppressed genes, including fatty acid synthase (FASN), which are involved in lipid metabolism. Overexpression of FASN or the addition of its downstream product, palmitate, increased …

Notch-Induced Mdsc Recruitment After Ohsv Virotherapy In Cns Cancer Models Modulates Antitumor Immunotherapy, Yoshihiro Otani, Ji Young Yoo, Cole T Lewis, Samantha Chao, Jessica Swanner, Toshihiko Shimizu, Jin Muk Kang, Sara A Murphy, Kimberly Rivera-Caraballo, Bangxing Hong, Joseph C Glorioso, Hiroshi Nakashima, Sean E Lawler, Yeshavanth Banasavadi-Siddegowda, John D Heiss, Yuanqing Yan, Guangsheng Pei, Michael A Caligiuri, Zhongming Zhao, E Antonio Chiocca, Jianhua Yu, Balveen Kaur

Faculty, Staff and Student Publications

PURPOSE: Oncolytic herpes simplex virus-1 (oHSV) infection of brain tumors activates NOTCH, however the consequences of NOTCH on oHSV-induced immunotherapy is largely unknown. Here we evaluated the impact of NOTCH blockade on virus-induced immunotherapy.

EXPERIMENTAL DESIGN: RNA sequencing (RNA-seq), TCGA data analysis, flow cytometry, Luminex- and ELISA-based assays, brain tumor animal models, and serum analysis of patients with recurrent glioblastoma (GBM) treated with oHSV was used to evaluate the effect of NOTCH signaling on virus-induced immunotherapy.

RESULTS: TCGA data analysis of patients with grade IV glioma and oHSV treatment of experimental brain tumors in mice showed that NOTCH signaling significantly …

Prevalence Of Metabolic Syndrome Among The Adult Population In Western China And The Association With Socioeconomic And Individual Factors: Four Cross-Sectional Studies, Xinyin Xu, Jing Zeng, Wei Yang, Ting Dong, Xin Zhang, Shuwen Cheng, Xiaobo Zhou, Maigeng Zhou, Ling Niu, Guanghui Yi, You Li, Lishi Zhang, Yin Deng, Xianping Wu

Faculty, Staff and Student Publications

Objectives: This study explored the prevalence of and individual influencing factors for metabolic syndrome (MS) as well as associated socioeconomic factors and regional aggregation.

Design: Four cross-sectional surveys were analysed for trends in MS and associations with socioeconomic and individual factors through multilevel logistic regression analyses. The risk associated with nutrient intake was also assessed through a dietary survey in 2015.

Setting: From 2010 to 2018, 8-15 counties/districts of West China were included.

Participants: A total of 28 274 adults were included in the prevalence analysis. A total of 23 708 adults were used to analyse the related factors.

Results: …

Patients With Chronic Pain Exhibit Individually Unique Cortical Signatures Of Pain Encoding, Astrid Mayr, Pauline Jahn, Anne Stankewitz, Bettina Deak, Anderson M. Winkler, Viktor Witkovsky, Ozan Eren, Andreas Straube, Enrico Schulz

School of Medicine Publications

Chronic pain is characterised by an ongoing and fluctuating intensity over time. Here, we investigated how the trajectory of the patients' endogenous pain is encoded in the brain. In repeated functional MRI (fMRI) sessions, 20 patients with chronic back pain and 20 patients with chronic migraine were asked to continuously rate the intensity of their endogenous pain. Linear mixed effects models were used to disentangle cortical processes related to pain intensity and to pain intensity changes. At group level, we found that the intensity of pain in patients with chronic back pain is encoded in the anterior insular cortex, the …

Midlife Vascular Factors And Prevalence Of Mild Cognitive Impairment In Late-Life In Mexico, Miguel Arce Renteria, Jennifer J. Manly, Jet M. J. Vonk, Silvia Mejia-Arango, Alejandra Michaels Obregon, Rafael Samper-Ternent, Rebeca Wong, Sandra Barral, Giuseppe Tosto

School of Medicine Publications

Objective: To estimate the prevalence of mild cognitive impairment (MCI) and its subtypes and investigate the impact of midlife cardiovascular risk factors on late-life MCI among the aging Mexican population.

Method: Analyses included a sample of non-demented adults over the age of 55 living in both urban and rural areas of Mexico (N = 1807). MCI diagnosis was assigned based on a comprehensive cognitive assessment assessing the domains of memory, executive functioning, language, and visuospatial ability. The normative sample was selected by means of the robust norms approach. Cognitive impairment was defined by a 1.5-SD cut-off per cognitive domain using …

Acute Generalized Exanthematous Pustulosis: A Painful And Pruritic Presentation Of Pustulosis Following Pharmacotherapy For Pharyngeal Phlegmon., Chase Silvers, John Casey

Ambulatory and Primary Care Articles

Acute generalized exanthematous pustulosis (AGEP) is primarily a drug-induced skin eruption, which typically presents within two days of starting an offending medication; it is often self-limiting with spontaneous resolution within two weeks upon medication cessation. We report the case of a patient who presented with generalized desquamation, characteristic pustules, and several morbilliform rashes on the body surface in association with recent amoxicillin-clavulanic acid exposure. This was associated with significant pruritus, which was the associated chief complaint. A multimodal approach to symptomatic management with topical corticosteroids, barrier ointments, oral antihistamines, and analgesics was required, in addition to the cessation of the …

Strategies To Improve Communication In Healthcare: An Integrative Review, Tracy Lynn Macdonald

Doctoral Dissertations and Projects

The purpose of this integrative review is to research, analyze, critique, and synthesize current literature to determine current practice of communication within healthcare. Communication errors continue to have a negative impact on patient outcomes, so this literature review will consider current strategies to improve communication, and thus improve patient outcomes. Several themes were identified as strategies to improve communication. Although there is abundant research on the topic of communication in healthcare, there is still a need for further adoption and implementation of various communication strategies, as well as a need for further evaluation to determine if these strategies do improve …

Predicted Burnout From A Linear Combination Of Personal And Cultural Factors For Departmental Chairs At Academic Health Centers, Loraine Annmarie Antoine

Doctoral Dissertations and Projects

Academic departmental chairs at academic health centers have multifaceted roles that entail of faculty obligations, leadership tasks, and the provision of clinical care. Increasing job demands at academic healthcare centers and higher education institutions has led to an increase in burnout, job dissatisfaction, and attrition of faculty and departmental chairs. Departmental chairs at academic health centers must determine strategies to balance their multiple roles held at their institution, as well as roles held in personal aspects of their lives. The purpose of this study was to identify factors that contributed to turnover and job dissatisfaction for academic departmental chairs to …

Compassion Fatigue: The Effects Of Secondary Traumatic Stress And Vicarious Traumatization Among Baltimore Police Department Community Chaplains, Angela Teresa Jones-Ramirez

Doctoral Dissertations and Projects

Baltimore is plagued with a history of high crime, violence, and murder resulting in trauma. The purpose of the Doctor of Ministry action research project was to educate Baltimore Police Department (BPD) Community Chaplains concerning compassion fatigue while maintaining effective quality care. A two-day workshop was developed as an intervention to address the problem. Pretest and posttest surveys were administered using the Professional Quality of Life Scale, Version 5, and the Skovholt Professional Practitioner Resiliency and Self-Care Inventory. Data in the form of surveys, group notes, field notes, recorded testimonials, and stories were collected and analyzed. Results of the data …

First-In-Human, Open-Label, Phase 1/2 Study Of The Monoclonal Antibody Programmed Cell Death Protein-1 (Pd-1) Inhibitor Cetrelimab (Jnj-63723283) In Patients With Advanced Cancers, Enriqueta Felip, Daniel Morgensztern, Et Al.

2020-Current year OA Pubs

PURPOSE: To assess the safety, pharmacokinetics, pharmacodynamics, and preliminary efficacy of cetrelimab (JNJ-63723283), a monoclonal antibody programmed cell death protein-1 (PD-1) inhibitor, in patients with advanced/refractory solid tumors in the phase 1/2 LUC1001 study.

METHODS: In phase 1, patients with advanced solid tumors received intravenous cetrelimab 80, 240, 460, or 800 mg every 2 weeks (Q2W) or 480 mg Q4W. In phase 2, patients with melanoma, non-small-cell lung cancer (NSCLC), and microsatellite instability-high (MSI-H)/DNA mismatch repair-deficient colorectal cancer (CRC) received cetrelimab 240 mg Q2W. Response was assessed Q8W until Week 24 and Q12W thereafter.

RESULTS: In phase 1, 58 patients …