Medicine and Health Sciences Commons^™

Exposure To Negative News Stories About Vaping, And Harm Perceptions Of Vaping, Among Youth In England, Canada, And The United States Before And After The Outbreak Of E-Cigarette Or Vaping-Associated Lung Injury (‘Evali’), Katherine East, Jessica L. Reid, Robin Burkhalter, Olivia A. Wackowski, Jim Thrasher Ph.D., Ma, Ms, Harry Tattan-Birch, Christian Boudreau, Maansi Bansal-Travers, Alex C. Liber, Ann Mcneill, David Hammond

Faculty Publications

Introduction

Little is known about the international impact of E-cigarette or Vaping-Associated Lung Injury (‘EVALI’) on youth perceptions of vaping harms. Methods

Repeat cross-sectional online surveys of youth aged 16–19 years in England, Canada, and the United States before (2017, 2018), during (2019 August/September), and after (2020 February/March, 2020 August) the ‘EVALI’ outbreak (N = 63380). Logistic regressions assessed trends, country differences, and associations between exposure to negative news stories about vaping and vaping harm perceptions. Results

Exposure to negative news stories increased between 2017 and February–March 2020 in England (12.6% to 34.2%), Canada (16.7% to 56.9%), and the United …

Privacy-Preserving Logistic Regression With Secret Sharing, Ali Reza Ghavamipour, Fatih Turkmen, Xiaoqian Jiang

Faculty, Staff and Student Publications

BACKGROUND: Logistic regression (LR) is a widely used classification method for modeling binary outcomes in many medical data classification tasks. Researchers that collect and combine datasets from various data custodians and jurisdictions can greatly benefit from the increased statistical power to support their analysis goals. However, combining data from different sources creates serious privacy concerns that need to be addressed.

METHODS: In this paper, we propose two privacy-preserving protocols for performing logistic regression with the Newton-Raphson method in the estimation of parameters. Our proposals are based on secure Multi-Party Computation (MPC) and tailored to the honest majority and dishonest majority …

Mcph1: A Novel Case Report And A Review Of The Literature, Stefano Giuseppe Caraffi, Marzia Pollazzon, Muhammad Farooq, Ambrin Fatima, Lars Allan Larsen, Roberta Zuntini, Manuela Napoli, Livia Garavelli

Department of Biological & Biomedical Sciences

Microcephaly primary hereditary (MCPH) is a congenital disease characterized by nonsyndromic reduction in brain size due to impaired neurogenesis, often associated with a variable degree of intellectual disability (ID). The genetic etiology of MCPH is heterogeneous and comprises more than 20 loci, nearly all following a recessive inheritance pattern. The first causative gene identified, MCPH1 or Microcephalin, encodes a centrosomal protein that modulates chromosome condensation and cell cycle progression. It is also involved in DNA damage response and telomere maintenance in the nucleus. Despite numerous studies on MCPH1 function, MCPH1-affected individuals are rare and the available clinical reports are …

Patterns Of Amygdala Region Pathology In Late-Nc: Subtypes That Differ With Regard To Tdp-43 Histopathology, Genetic Risk Factors, And Comorbid Pathologies, Matthew D. Cykowski, Anithachristy S. Arumanayagam, Suzanne Z. Powell, Andreana L. Rivera, Erin L. Abner, Gustavo C. Roman, Joseph C. Masdeu, Peter T. Nelson

Sanders-Brown Center on Aging Faculty Publications

Transactive response (TAR) DNA-binding protein 43 kDa (TDP-43) pathology is a hallmark of limbic-predominant agerelated TDP-43 encephalopathy (LATE). The amygdala is afected early in the evolution of LATE neuropathologic change (LATE-NC), and heterogeneity of LATE-NC in amygdala has previously been observed. However, much remains to be learned about how LATE-NC originates and progresses in the brain. To address this, we assessed TDP-43 and other pathologies in the amygdala region of 184 autopsied subjects (median age=85 years), blinded to clinical diagnoses, other neuropathologic diagnoses, and risk genotype information. As previously described, LATE-NC was associated with older age at death, cognitive impairment, …

Beyond Trauma-Informed Care: Insights From A Qualitative Study, Danielle Gainer, Sydney Silverstein, Josef Rivera, Raminta Daniulaityte

Psychiatry Faculty Publications

Background: The impact of opioid use disorder (OUD) upon communities across the United States remains at epidemic levels, with a record number of overdose deaths recorded in 2020. As many communities have responded to this ongoing crisis with evidence-based treatment, harm reduction interventions and pharmacotherapy, recent efforts have focused on trauma-informed approaches to SUD care, taking into account the high prevalence of Adverse Childhood Experiences and related trauma in the lives of people living with OUD (Felliti, 1998; Stein, 2017). However, experiences of trauma and the manifestations of trauma in contemporary experience are never uniform (Maté, 2009). Qualitative research among …

Targeted Osmotic Lysis: A Novel Approach To Targeted Cancer Therapies, Harry J. Gould, Dennis Paul

School of Medicine Faculty Publications

The conventional treatment of cancer has been based on the delivery of non-selective toxins and/or ionizing energy that affect both the cancer and normal tissues in the hope of destroying the offending disease before killing the patient. Unfortunately, resistance often develops to these treatments and patients experience severe, dose-limiting adverse effects that reduce treatment efficacy and compromise quality of life. Recent advances in our knowledge of the biology of tumor cells and their microenvironment, the recognition of surface proteins that are unique to specific cancers and essential to cell growth and survival and signaling pathways associate with invasion and metastasis …

Spata7 Is Required For Maintenance Of The Retinal Connecting Cilium, Jiaxiong Lu, Kaitlyn Xiong, Xinye Qian, Jongsu Choi, Yoon-Kyung Shim, Jacob Burnett, Graeme Mardon, Rui Chen

Faculty, Staff and Students Publications

SPATA7, an early onset LCA3 retinal disease gene, encodes a putative scaffold protein that is essential for the proper assembly of the connecting cilium (CC) complex in photoreceptors. Previous studies have shown that SPATA7 interacts with other photoreceptor-specific ciliary proteins, such as RPGR and RPGRIP1, and maintains the integrity of CC integrity. However, although it is known that Spata7 is required for early formation of the CC, it is unclear if Spata7 is also required for the maintenance of the CC. To investigate Spata7 function in the retina at the adult stage, loss of function was induced in the …

Effects Of Dicationic Imidazolium-Based Ionic Liquid Coatings On Oral Osseointegration Of Titanium Implants: A Biocompatibility Study In Multiple Rat Demographics, Sutton E. Wheelis, Cláudia Cristina Biguetti, Shruti Natarajan, Bhuvana Lakkasetter Chandrashekar, Alexandra Arteaga, Jihad El Allami, Gustavo P. Garlet, Danieli C. Rodrigues

School of Podiatric Medicine Publications

Dicationic imidazolium-based ionic liquids with amino acid anions, such as IonL-phenylalanine (IonL-Phe), have been proposed as a multifunctional coating for titanium (Ti) dental implants. However, there has been no evaluation of the biocompatibility of these Ti coatings in the oral environment. This study aims to evaluate the effects of IonL-Phe on early healing and osseointegration of Ti in multiple rat demographics. IonL-Phe-coated and uncoated Ti screws were implanted into four demographic groups of rats to represent biological variations that could affect healing: young males (YMs) and females (YFs), ovariectomized (OVXFs) females, and old males (OMs). Samples underwent histopathological and histomorphometric …

Fall Risk Prediction Model For Older Men And Women Based On Ambulatory Physical Activity Level – A Cross-Sectional Population-Based Study From The Oporto Region, Paulo Jorge Quintela Cardoso-Carmo, Adjane Maria Pontes César, Manuel Rubim Silva Santos, Maria Joana Mesquita Barbosa De Carvalho

Baltic Journal of Health and Physical Activity

Introduction. Falls among the elderly are an important community health problem due to its high incidence, functional and social repercussion. Dissimilar results arose in recent studies concerning fall risk and physical activity levels. This study measures the association between physical activity (PA) levels, and fall risk (FR), investigates which levels of PA are influential in FR and presents a fall risk prediction models for the elderly. Material and Methods. One hundred and seventy elderly adults (72.34 ± 6.70 years old, 124 female), completed Performance-Orientated-Mobility-Assessment; PA was assessed by accelerometry. Pearson’s correlation verified the association between FR, Age, and PA. Multiple …

On My Mind, William L. Blizek

Journal of Religion & Film

This is a review of the short film On My Mind (2021), directed by Martin Stange-Hansen.

Determinants Of State Average Life Expectancy, Alex Grimes, Spencer Sprague, Cole Thomas

Student Scholarship - College of Business

In this paper, our dependent variable is average life expectancy by state in the United States. The purpose is to determine which factors have an impact on average life expectancy, as well as the magnitude of these impacts. While other studies have been conducted on life expectancy, our focus is different in a subtle but important way. Rather than centering on individual life expectancy, studying factors like “activity” or “genetics,” we focus on the broader population in a state and which factors affect life expectancy on a macro-scale. There is little known about this topic that isn’t in direct reference …

Virtual Is Now Reality: Telehealth To Deliver Care For Substance Use Disorders, Brian Merrill, Danielle Gainer, Brent Schnipke

Psychiatry Faculty Publications

Models of care for substance use disorder (SUD) treatment have traditionally required face-to-face visits, since individuals receive a broad range of services including individual psychotherapy, group therapy, urine drug screens, laboratory testing, dispensation of Medications for Opioid Use Disorder (MOUD), and prescriptions for psychotropic or other medications. However, during the COVID-19 pandemic, telehealth became a more widely used method of delivering healthcare, including for SUD treatment. While the pandemic posed respiratory health concerns to all, individuals with a SUD were additionally vulnerable when attempting to access life-saving medications. An enforcement waiver of both federal and state telehealth rules during the …

Exercise Testing And Prescription With Cancer Patients To Help Relieve Cancer-Related Fatigue (Crf), Tanner Hendricks, Paul Williams

EXSI 432/532: Research Methods in Exercise Science: Research Proposal Posters

CRF is one of the most prominent side effects in cancer patients (Savina & Zaydiner, 2019). 80-100% of cancer patients report experiencing CRF (American Cancer Society, 2020) • Rest was a crucial recommendation for cancer patients, but now it is being replaced with physical activity (Backer et al., 2007). CRF can lead to: (Horneber et al., 2012): decreased physical activity, hinderance of recovery, Mood swings (depression often occurs), exhaustion (physical and mental), impaired physical performance.

Pathology Of Atrial Fibrillation And Methods For Testing And Prescribing Exercise, Abby Callahan, Logan Barrett

EXSI 432/532: Research Methods in Exercise Science: Research Proposal Posters

Atrial fibrillation is one of the most common arrhythmias which is diagnosed to nearly 450,000 Americans each year (CDC, 2021). Atrial fibrillation is a conduction defect of the atria and is often characterized as an irregular heart rate that often causes poor blood flow. Atrial fibrillation is commonly associated with very rapid and chaotic atrial depolarizations that result in an irregular and sometimes rapid response of the ventricles (Jacobs, 2018). This condition can potentially have no symptoms, but when symptoms do appear they can include shortness of breath, fatigue, and palpitations. Treatments of atrial fibrillation include blood thinners, minimally invasive …

The Effects Of Occupational Therapy For Damaged Hand Muscles In Females With Scleroderma, Abby Callahan

EXSI 432/532: Research Methods in Exercise Science: Research Proposal Posters

Scleroderma limits individuals in normal activities of daily living. Occupational therapy is recommended for individuals with scleroderma within the first few years of the disease. Studies have shown that occupational therapy is effective in individuals with scleroderma. Scleroderma or systemic sclerosis is a complex polygenetic disease that has 2 subtypes: Limited Affects individuals' muscles and how they functions, Diffuse Affects individuals’ internal organs (Shah, 2013). The purpose of this study is to determine the effects of occupational therapy in damaged hand muscles of females with scleroderma.

Study Of Glucose Supplementation On Antibiotic Efficacy Against Staphylococcus Aureus, Areej Malik, Alexandra E. Chittams-Miles, Claudia Muratori, Erin B. Purcell

College of Sciences Posters

Staphylococcus aureus (S. aureus), is a Gram-positive, facultative anaerobic, biofilm-forming bacterium. It is the leading cause of skin and soft tissue infections (SSTIs) in the United States. The public health impact of S. aureus has been increased by the emergence of Methicillin-resistant Staphylococcus aureus. It has also shown intermediate resistance to Vancomycin, which suggests that full resistance may develop. It is known that hyperglycemia (high blood sugar) from diabetes reduces immune system function. Patients with diabetes experience a greater rate of skin and soft tissue infections. This research explores the effect of increasing glucose concentration on S. …

Com Outlook (Winter/Spring 2022 - Volume 23 Number 1), Nova Southeastern University

COM Outlook

No abstract provided.

Exploring Compassion For The Community And Diversity Through Nursing Experiential Learning, Jaime Sinutko, Nadine Wodwaski, Brooklin Adams

Experiential Learning & Teaching in Higher Education

Background: The aim of Jesuit education is total growth leading to action (Jesuit Institute, 2014a), plus higher Jesuit education seeks to transform students through examining the world around them. The promotion of experiential learning is noted in Ignatian Pedagogy (2014a) by urging the whole person to enter the learning experience. Nursing education, at a Jesuit University, involves educating the whole person within a service-oriented profession. Thus, experiential learning in a nursing course at a Jesuit University is an active component of Ignatian pedagogy, promoting Jesuit values and Catholic identity. This has been challenging since the COVID-19 pandemic forced universities to …

Pressure Ulcer Prevention: A Quality Improvement Project, Noah Blevins, Graci Borders, Brett Bentley, Carly Crutchfield, Rachel Dillion, Jacob Dyer, Heleigh Eldridge, Taylor Emmons, Suzi White

2022 Celebration of Student Scholarship - Poster Presentations

A pressure ulcer is an injury that affects the underlying tissue and skin and is primarily caused by prolonged pressure on the skin. During a clinical rotation at a small rural teaching hospital, pressure ulcers were prevalent in an estimated 80% of patients in the intensive care unit (ICU) during a three-week period. Approximately $26.8 billion are spent every year in the United States treating pressure ulcers. The purpose of this quality improvement project is to provide staff education to ICU nurses in order to reduce and prevent the prevalence of pressure ulcers in patients. A thorough literature review was …

The Perception Of Minority Student-Athletes’ And Non-Athlete Students’ Learning Experience At A Predominately White Institution, William Wellman, Jelani Garvin, Jane Zhang, Steve Chen

2022 Celebration of Student Scholarship - Poster Presentations

This study examined mainly African-American and minority students' learning experience at a regional public university in Appalachia for the purpose of improving the existing academic support services and creating a safe diverse learning environment for racial minority students.

Frequency Of Genetic Variants At The Mc1r Locus In A Student Population, Emmalea K. Dowdy, Grace C. Stubblefield, David K. Peyton

2022 Celebration of Student Scholarship - Poster Presentations

The Melanocortin-1 Receptor gene (MC1R) encodes a protein that is associated with pigmentation in vertebrate animals. An extraordinary number of variations in this gene have arisen over time due to the importance of pigmentation in camouflage, photosensitivity, vitamin D production, and other evolutionary factors. Variations in the MC1R gene sequence became important to survival as humans migrated out of Africa and into cooler climates with less sun exposure, where lighter skin pigmentation (and therefore more vitamin D production) was key to survival. These genetic variations (alleles) continue to exist in modern humans. Recent research into the MC1R gene variations shows …

Research, Testing, And Validation Of Small Satellite Designs: Cubesats, Cansats, Pocketqubes, And Femtosatellites, Jason A. Combs, Jose L. Garcia

2022 Celebration of Student Scholarship - Poster Presentations

The focus of this project, through research and testing, was to prepare various elements of small satellite experiential education curriculum. Rather than be constrained to the expensive and long-term timelines of a larger satellites, students can assemble, test, and operate various classes of small satellites in a valuable learning experience that will prepare them to work on larger projects. The true benefit of a PocketQube, CanSat, or femtosatellite is that they can be built with less money, less experience, and less long-term commitment while providing a scaled version of the real-life satellite development process that will engage and inspire students. …

Novel Gain-Of-Function Mutations In The Telomerase Rna Of Saccharomyces Cerevisiae, Keenan Conley, Madison Frazier, Melissa Mefford

2022 Celebration of Student Scholarship - Poster Presentations

Yeast are eukaryotic organisms that contain liner chromosomes. At the ends of these chromosomes, there are special regions known as telomeres. Telomeres are composed of non-coding nucleotides that serve to protect the vital coding DNA found throughout the rest of the chromosome. During the process of DNA replication, however, telomeres become progressively shorter which can lead to cellular senescence. To solve this issue, yeast express the enzyme telomerase. Telomerase is composed of a telomerase reverse transcriptase protein (TERT) and telomerase RNA (TLC1) in yeast. When telomeres become too short, telomerase extends telomeres by adding to the 3’ overhang. Telomeres shorten …

Technology In Workplace Communication By Generation, Hannah Meadows, Christy Trent

2022 Celebration of Student Scholarship - Poster Presentations

The purpose of this research study was to determine the generational differences in the use of communication technology in the workplace. Most employees feel a deeper sense of connection to those in their own generational group. This survey looks at ideologies across four generations, Baby Boomers, Generation X, Millennials, and Generation Z, to help give employers some insight into why employees feel this way and encourage better communication in the workforce.

Fungi In A Warmer World: Fungal Diversity In The Tropical Miocene Climate Optimum Of The Clarkia Region Of Idaho, Usa, J. Fairchild, L. Lennex-Stone, T. Horsfall, L. Tarlton, S. Jones, A. Caldwell, O. Vanderespt, L. Smallwood, A. Patel, J. O'Keefe, I. Romero, N. Nunnez Otano, M. Pound

2022 Celebration of Student Scholarship - Poster Presentations

A knowledge gap associated with how fungal communities change in response to climate was identified in the 2018 State of the World Fungi report (Willis, 2018). While it is virtually impossible to test in the present, fungal assemblage changes can be studied in sediments from a warmer-than-present period such as the Miocene Climate Optimum (MCO) (Romero et al. 2021; O’Keefe 2017). The Fungi in a Warmer World project aims to generate and analyze a global-scale data set of fungal biodiversity, ecology, and associated flora from MCO sediments. This dataset will be used to model past fungal assemblage changes across the …

Morphometrics Of The Rare Earwigfly Merope Tuber, Nicholas Finch, Sean O'Keefe

2022 Celebration of Student Scholarship - Poster Presentations

Merope tuber Newman (Mecoptera: Meropeidae) is a rare North American species of earwigfly, which is closely related to common scorpionflies. “Earwigfly” refers to three different species: the Western Australian Austromerope poulton, the South American Austromerope brasiliensis, and finally, the Eastern North American Merope tuber. This last species was the focus of our study. Johnson’s 1995 study was based on 160 earwigflies, where he measured the female abdomen length, male and female forewing length, and male basistylus and dististylus length. In their 2014 study, based on 82 earwigflies, Skvarla, Hartshorn, and Dowling measured head width, pronotum width, forewing length, abdomen length, …

Encouraging Increased Ppe Compliance: A Quality Improvement Project, Christen Ballard, Hannah Carpenter, Skyler Harper, Angela Marcum, Suzi White

2022 Celebration of Student Scholarship - Poster Presentations

Personal protective equipment (PPE) is used to minimize infection transmission from patient to healthcare worker, or vice versa. During a clinical rotation in a large urban teaching hospital, it was noted that a number of nurses failed to adhere to proper PPE policies. A literature review focusing on thirty-two studies found that average nurse compliance to proper PPE is 34%. This review included an overall discussion of factors affecting compliance, as well as a more in-depth review of the effect of education on PPE compliance, how comfort and proper fitting affects compliance, and the general effectiveness of PPE when used …

“The Never Ending Story:” Circularizing Ch. Viii In Saccharomyces Cerevisiae, Chisom Iloegbunam, Melissa Mefford

2022 Celebration of Student Scholarship - Poster Presentations

Chromosomes are molecules of DNA that hold large quantities of genetic material in an organism. Generally, in nature, eukaryotic chromosomes are linear while prokaryotic chromosomes are circular. Since they are linear, eukaryotic chromosomes possess telomeres, or repetitive nucleotide sequences, on their ends. This significant difference in structure requires different additions to the basic replication process. In prokaryotes, replication starts at a single point on the chromosome and continues until the whole chromosome has been copied. In eukaryotes, replication happens in fragments with multiple starting points. Because of this more complicated replication process, the free 3’ ends of our DNA cannot …

College Students’ Knowledge And Use Of Herbal Supplements: Informed Decision, Health Risk, Or Marketing Ploy?, Jillian Wallshield, Wilson Gonzalez-Espada

2022 Celebration of Student Scholarship - Poster Presentations

The purpose of this study is to better understand the extent to which college students from Eastern Kentucky use Herbal Supplements (HS). The research questions for this study were:

• How do the participants find out about HS?

• How helpful do participants perceive the HS they take to be?

• What misconceptions do participants have regarding HS?

• Does a positive or negative attitude towards science change the usage rate of HS?

A New Colorimetric Assay Of Apurinic/Apyrimidinic (Abasic) Sites Of Deoxyribonucleic Acid (Dna) Using Bicinchoninic Acid [, Isaiah O. Stephens, Elizabeth M. Thomas

2022 Celebration of Student Scholarship - Poster Presentations

Apurinic/apyrimidinic (AP or abasic) sites are DNA lesions that result from the loss of a nucleobase by hydrolysis of the N-glycosyl bond. It is estimated that AP sites are the most frequent lesions in cells with about 10,000-50,000 times per day per cell under typical aerobic conditions [2]. The formation of AP sites is caused by environmental and cancer therapeutic genotoxins such as alkylating agents, oxidizing agents, ionizing radiation, and ultraviolet radiation.