Medicine and Health Sciences Commons^™

Independent And Interactive Effects Of Genetic Background And Sex On Tissue Metabolomes Of Adipose, Skeletal Muscle, And Liver In Mice., Ann E Wells, William T Barrington, Stephen Dearth, Nikhil Milind, Gregory W. Carter, David W Threadgill, Shawn R Campagna, Brynn H Voy

Faculty Research 2022

Genetics play an important role in the development of metabolic diseases. However, the relative influence of genetic variation on metabolism is not well defined, particularly in tissues, where metabolic dysfunction that leads to disease occurs. We used inbred strains of laboratory mice to evaluate the impact of genetic variation on the metabolomes of tissues that play central roles in metabolic diseases. We chose a set of four common inbred strains that have different levels of susceptibility to obesity, insulin resistance, and other common metabolic disorders. At the ages used, and under standard husbandry conditions, these lines are not overtly diseased. …

Role Of Percutaneous Tibial Nerve Stimulation In The Management Of The Detrusor Overactivity, Abourjila A. Gamal Eldin, Amr M. Elsofy, Ayman M. Gabr, Emad K. El Tair

Journal of Medicine in Scientific Research

Introduction Percutaneous tibial nerve stimulation (PTNS) is a technique that was developed a decade or more ago, but it does not seem to have become widely adopted into clinical practice. Aim The purpose of this study is focused on the efficacy of PTNS for the treatment of an overactive bladder. Patients and methods Between September 2016 and October 2019, this study included 40 patients who are complaining of irritative voiding symptoms, such as frequency, urgency, nocturia, enuresis, and urge incontinence. Those patients are divided into two equal groups subjected to PTNS and sham groups. Results Only 40 patients completed the …

Prevalence, Phenotypic Distribution, And Clinical Characteristics Of Polycystic Ovary Syndrome In Egyptian Women With Type 1 Diabetes Mellitus, Ayat I. Ghanem, Dina H. Abd Elmonem, Eman M. Aly, Fatma K. Hammad

Journal of Medicine in Scientific Research

Background Type 1 diabetes mellitus (T1DM) has shown a steady increase in prevalence in most parts of the world. Polycystic ovary syndrome (PCOS) frequently occurs in 15–20% of women in their reproductive age. It is associated with subfertility, ovulatory dysfunction, dysregulated androgen biosynthesis, and increased risk of insulin resistance. This study aims to assess the prevalence, phenotypic distribution, and clinical characteristics of PCOS in a sample of Egyptian women with T1DM. Patients and methods A total of 100 Egyptian women in their reproductive age (18–42 years old) previously diagnosed as having T1DM were recruited in the study. They were screened …

Determination Of The Level Of Cd4cd69 T Cells In Hemodialysis Patients, Ahmed A. A. Megeed, Azza A. I. Elmenyawi, Mohamed Salah, Nehad R. Ibrahim

Journal of Medicine in Scientific Research

Introduction The CD4 helper T cell is responsible for humoral, cellular immunity, and inflammation. CD69 may be a sensitive marker indicating that the CD4 T cell is activated. The aim of this study is to determine CD4CD69 T cells for estimating the activation of CD4 T cells and to monitor hemodialysis (HD) outcome. Participants and methods Sixty-two HD patients and 50 controls were enrolled in our study. CD3, CD4, CD3CD69, and CD4CD69 T cell percentages were assessed by flow cytometry. Transferrin was determined using ELISA. Results The lymphocyte count, the CD3 T cell percentage and CD4 T cell percentage were …

Cytomorphological Evaluation Of Enlarged Lymph Nodes: A Tertiary Hospital-Based Study, Arun Dev Singh, Sheetal Chandel, Shivani Gandhi

Journal of Medicine in Scientific Research

Introduction Lymphadenopathy is one of the commonly encountered clinical presentations and early targets for aspiration; therefore, it provides an important clue toward the diagnosis of the underlying etiology. Patients and materials The present study was conducted in a tertiary care hospital in North India among 201 patients who underwent fine-needle aspiration cytology (FNAC) after gaining their informed consent. Results In the study, most patients were males (52.73%), with a male-to-female ratio of 1.1:1. The age group ranged from 1 to more than 80 years, with most patients in the age group of 21–30 years followed by 0–10 years and the …

Language Revitalization: Strategies To Reverse Language Shift, Jessica Martin

Student Research Symposium

Language shift, the process by which a language loses speakers until it becomes extinct, is occurring in speech communities all over the world. This process is influenced by internal and external political, social, and economic factors unique to each community. As its causes and effects are not uniform, a universal model for reversing language shift does not exist. However, several broad principles can be applied across multiple contexts and situations for successful language revitalization. It is essential for the speech community to be the primary decision maker in any program. A thorough assessment of the community’s current status, challenges, and …

Perceptions Of Hypertension And Treatment Adherence In Impoverished Hypertensive Adults: A Qualitative Analysis, Sarah E. Hogg

Honors College Theses

Hypertension is a global public health crisis. It is the largest risk factor for cardiovascular disease, which is the leading cause of death globally (CDC, 2021). While it can be managed, there are additional barriers that hypertensive impoverished populations face in regards to hypertension management. The purpose of this study was to explore knowledge, attitudes, and perceptions of hypertension, and treatment adherence in impoverished hypertensive adults. Interviews were analyzed using thematic analysis, and were explained within the context of the health belief model. The results show that there was a lack of understanding of hypertension and its long term effects. …

Narrative Review - Optimal Occupational Therapy Experience, Kaylee G. Clay

Honors College Theses

This narrative review examines factors associated with optimal occupational therapy experiences, including patient perspectives of occupational therapy, cost-effectiveness, use of practices, organization, and patient involvement/experiences. The information found within this review provides information to those interested in creating the most optimal experiences for their occupational therapy patients.

Modulating Tumour Hypoxia In Prostate Cancer Through Exercise: The Impact Of Redox Signalling On Radiosensitivity, Malcolm Brown, Amélie Rébillard, Nicolas H. Hart, Dominic O’Connor, Gillian Prue, Joe M. O’Sullivan, Suneil Jain

Research outputs 2022 to 2026

Prostate cancer is a complex disease affecting millions of men globally. Radiotherapy (RT) is a common treatment modality although treatment efficacy is dependent upon several features within the tumour microenvironment (TME), especially hypoxia. A hypoxic TME heightens radioresistance and thus disease recurrence and treatment failure continues to pose important challenges. However, the TME evolves under the influence of factors in systemic circulation and cellular crosstalk, underscoring its potential to be acutely and therapeutically modified. Early preclinical evidence suggests exercise may affect tumour growth and some of the benefits drawn, could act to radiosensitise tumours to treatment. Intracellular perturbations in skeletal …

Evaluating The Dissemination And Implementation Of A Community Health Worker-Based Community Wide Campaign To Improve Fruit And Vegetable Intake And Physical Activity Among Latinos Along The U.S.-Mexico Border, Paul Gerardo Yeh, Belinda M. Reininger, Lisa A. Mitchell-Bennett, Minjae Lee, Tianlin Xu, Amanda C. Davé, Soo Kyung Park, Alma G. Ochoa-Del Toro

Physician Assistant Studies Faculty Publications

This study evaluated the dissemination and implementation of a culturally tailored community-wide campaign (CWC), Tu Salud ¡Si Cuenta! (TSSC), to augment fruit and vegetable (FV) consumption and physical activity (PA) engagement among low-income Latinos of Mexican descent living along the U.S.-Mexico Border in Texas. TSSC used longitudinal community health worker (CHW) home visits as a core vehicle to enact positive change across all socioecological levels to induce behavioral change. TSSC’s reach, effectiveness, adoption, implementation, and maintenance (RE-AIM) was examined. A dietary questionnaire and the Godin-Shepherd Exercise Questionnaire measured program effectiveness on mean daily FV consumption and weekly PA engagement, respectively. …

Qualitative Analysis Of South Dakota Community Health Needs Assessments, Rachel Greiner

Honors Thesis

The supplemental nutrition program of women, infants and children (WIC) is a nationwide program designed to give women and children access to basic nutritional foods, breastfeeding services, and healthcare referrals. WIC has been shown to help prevent some diseases such as nutritional deficiencies or type two diabetes by requiring participants to attend pre- and postnatal appointments and nutritional counseling. The effectiveness of the WIC program is not well known in individual states. The purpose of this research is to identify trends of the WIC program and resources within South Dakota through an analysis of the community health needs assessments. The …

Developing An Educational Foundation For Incorporating Animal Assisted Interventions Into Rehabilitation Settings, Chandni Vyas

OTD Capstone Projects

The purpose of this capstone experience was to identify and fill the need for standardized education in the field of occupational and physical therapy regarding the implementation of animal-assisted interventions (AAI) into treatment. Working with Belmont University Professor, Dr. Christi Williams, PTT, DPT, OCS, Cert MDT, a course describing the foundations of AAI in practice was created to provide occupational and physical therapy practitioners with a standardized educational course for incorporating therapy animal teams into client-centered interventions. The course was piloted on students in both fields, and a feedback survey was utilized to learn about the attitudes regarding the appropriateness …

A Practical Approach To Assessing Physical Freshness: Utility Of A Simple Perceived Physical Freshness Status Scale, Okba Selmi, Danielle E. Levitt, Filipe Manuel Clemente, Hadi Nobari, Giulia My, Antonella Muscella, Katsuhiko Suzuki, Anissa Bouassida

School of Medicine Faculty Publications

Background: Monitoring physical freshness is essential in assessing athletes’ conditions during training periods, training sessions, or competitions. To date, no single physical freshness scale has been successfully validated against training load variables and widely used scales measuring different facets of physical freshness. Objective: In this study, we develop and test the practical utility of a perceived physical freshness (RPF) scale to monitor the condition of the athletes and to prevent excessive fatigue and insufficient recovery during training sessions or competitions. Methods: Sixteen professional male soccer players (mean ± SD age 26 ± 4 years) were enrolled. Training load (TL), monotony, …

Working Memory Capactiy And Speech Perception With Hearing Aids, Ethan Watson

Student Research Symposium

This presentation covers an ongoing literature review that is asessing the relationship between working memory capcity and speech percpetion with hearing aids. It will provide a brief overview of the ELU model and how hearing aids create mismatch in our neural coding process of speech. Current results of what hearing aid signal stratgies relate to WMC will be provided.

The Development Of Controlled Attention, Lexie Scott, Katelin Pyfer

Student Research Symposium

The ability to maintain items of information within working memory is depending on the ability to allocate attention to items within WM. Individual differences in WM capacity may bedependent on the amount of information that can be held and maintained in the focus of attention. A basic question in cognitive development is whether individuals increase the capacity of the focus of attention or the efficiency with which they can process information. We examined the differences in typically developing children versus adults in the capacity and efficiency of attention control. In our study, children and young adults completed a dichotic attention …

Bodies Of Beauty, Tyaira Mackay

Student Research Symposium

The rates of eating disorder diagnoses amongst young people in the United States has gradually increased, while beauty standards have gained more prevalence. These beauty standards have become more unrealistic and glorify frail, stick-like bodies. This research aims to discover if there is any correlation between these unhealthy standards and the development and diagnosis of eating disorders. To conduct my research, I used library and internet sources to gather a pool of primary and secondary sources. I used sources by underrepresented scholars concerning different body standards as well as information given by eating disorder clinics to gain a better understanding …

Short Term Stability Of The Electrical Stapedial Reflex, Emilee Harris

Student Research Symposium

Electrical stapedial reflex threshold (eSRT) is an objective measurement of the stapedial reflex triggering in response to loud electrical stimulation through the CI electrode. eSRT has been a valuable clinical tool in mapping the Cochlear Implant (CI) electrodes upper limits. The main objective of this study is to validate the changes in the eSRT within and across CI patients over one year post activation. In this study retrospective clinical data were analyzed from 44 patients ranging in age from 1-88 years, with a total of 29 left ear devices and 31 right ear devices activated in the years 2013-2020 with …

Addressing Als Caregiver Needs: An Occupation-Based Caregiver Education Program, Kylee Hall, Helen Carey, Lauren Webb, Lisa Griggs-Stapleton

Spring 2022 Virtual OTD Capstone Symposium

This program adds a new component to the Les Turner ALS Foundation’s already established online educational programs. The foundation had a program for people living with ALS but did not have a program for caregivers prior to this project.

A needs assessment was completed to determine caregiver needs and materials for caregivers were developed based on the needs found. The materials developed were implemented with ten caregivers to determine effectiveness and outcomes before launching the program to the general public.

Alpha-Fetoprotein (Afp) And Afp-L3 Is Most Useful In Detection Of Recurrence Of Hepatocellular Carcinoma In Patients After Tumor Ablation And With Low Afp Level, Madison Force, Grace Park, Divya Chalikonda, Christopher G. Roth, Micah Cohen, Dina Halegoua-De Marzio, Hie-Won Hann

Department of Medicine Faculty Papers

Hepatocellular carcinoma (HCC) is the most common primary malignancy of the liver and is a leading cause of mortality worldwide. While there are many risk factors for HCC including alcohol, obesity, and diabetes, hepatitis B virus (HBV) and hepatitis C virus (HCV) infection still account for the majority of HCC worldwide. Globally, HBV is the leading risk factor for HCC. Patients with chronic hepatitis B (CHB) and advanced liver disease are at high risk for HCC. Screening for HCC is done routinely with ultrasound with or without alpha-fetoprotein (AFP) at six-month intervals. The combination of ultrasound and AFP has been …

Cochlear Implantation In 602 Cases: Surgical Complications During 7 Years Of Experience In A Specialized Institute, Ahmed Mustafa, Ihab K. Sefein, Mohammad M. Gaballah

Journal of Medicine in Scientific Research

Aim To assess the complications of cochlear implantation (CI) during our 7 years of experience since the start of the CI program in our institute. Patients and methods The study included 602 CI procedures performed from April 2013 to January 2020. The follow-up period ranged between 12 and 73 months. Complications were classified into perioperative, major complications requiring reimplantation, major complications not requiring reimplantation, and minor complications. Collected data were statistically analyzed. Results Of the 602 implantations, 509 were children. Age ranged between 1.2 and 64 years. Mean implantation age in pediatrics was 4.4 and 31.07 years in adults. A …

Role Of The Viability Study To Solve The Dilemma Of The Management Of Moderate Ischemic Mitral Regurgitation: When To Do Revascularization Alone Or Revascularization And Mitral Valve Repair?, Ashraf Abdelaziz, Hazem G. Bakr, Ibrahim M. Helmi, Khaled S. Ahmed

Journal of Medicine in Scientific Research

Back ground The purpose of this study is to determine the role of the viability study to solve the dilemma of management of moderate ischemic mitral regurgitation (IMR): when to do revascularization alone or revascularization and mitral valve repair?. Patients and methods A retrospective study included 120 patients with ischemic heart disease (IHD) who underwent coronary artery bypass surgery (CABG) with IMR aged from 40 to 65 years of both sexes. They were divided into two groups of patients: Group I: 60 patients with IHD and moderate IMR had CABG for revascularization only. Group II: 60 patients with IHD and …

Does The Previous Stenting Affects The Outcome Of Coronary Artery Bypass Grafting In Patients With Multivessel Disease, Hazem G. Bakr, Ibrahim M. Helmi, Waleed A. Kamel

Journal of Medicine in Scientific Research

Background During the past decade, the number of percutaneous coronary interventions (PCI) performed before coronary artery bypass grafting (CABG) has risen significantly. Patients with more serious coronary pathology are referred for CABG, which can affect the postoperative outcome. Patients and methods Outcomes of 60 CABG patients, who were recruited in a prospective comparative study, were compared. Group A (n = 30) underwent primary CABG and group B (n = 30), had prior PCI before CABG. Results Total morbidity was substantially higher in the second group than in the first, with six patients in group A (nonstent group) and …

Highlight On Some Immune Disorders In Chronic Kidney Disease, Ahmed A. Abdel Megeed, Ahmed H. Elthakaby, Azza A. I. Elmenyawi, Nehad R. Ibrahim

Journal of Medicine in Scientific Research

Introduction Chronic inflammation and immune inadequacy are present in chronic kidney disease (CKD) patients. T-helper type 17 (Th17) cells give rise to interleukin (IL)-17, IL-22, and IL-23, cause neutrophils to drive to sites of infection, and enhance moderate immune reactions to microbes outside the cells. They are responsible for autoimmune diseases. Regulatory T (Treg) cells secrete anti-inflammatory cytokines IL-10 and transforming growth factor beta and suppress immune reactions to preserve immune homeostasis. The decreased count or disability of Treg leads to immune dysregulation. Endoplasmic reticulum stress (ERS) leads to unfolded protein response that is stimulated by glucose-regulated protein 78 (GRP78). …

The Outcome Of Managing Sleep Apnea In Children With Cerebral Palsy, Mohamed F. Alsoda, Samir H. Khalil, Wael M. Hossam

Journal of Medicine in Scientific Research

Background Obstructive sleep apnea (OSA) is not an uncommon finding in the pediatric age group patients with cerebral palsy (CP). Objective We aimed to evaluate the frequency of occurrence of OSA in children with CP and the most appropriate surgical procedures used in these patients. Study design A prospective study was carried out on 67 children with OSA, 36 of whom suffer from CP. The data included the presenting complaint, any coexisting illnesses, preoperative and postoperative polysomnography results, the primary surgical procedure performed, age at the time of surgery, number of postoperative hospitalization days in the ICU, and presence of …

Rate Of Reoperation After Strabismus Surgery, Heba Metwally

Journal of Medicine in Scientific Research

Aims To determine and analyze the reoperation rate during the first 1–2 years following surgical correction of strabismus using the conventional suture technique. Patients and methods This retrospective cohort study included patients of all ages who underwent surgical correction of strabismus with the conventional suture technique. Electronic medical records of the patients were reviewed. The extracted data included the patients' sociodemographics, the type of strabismus, history of the first strabismus surgery, presence of sequelae, and the need for reoperation. Results This study included 337 patients who underwent surgical correction of strabismus. Thirty (8.9%) out of 337 patients required reoperation. The …

Ectonucleotide Pyrophosphatase/Phosphodiesterase 1 (K121q Rs1044498) Polymorphism Is Associated With Diabetic Nephropathy But Not Obesity Among Type-2 Diabetes Mellitus Egyptian Patients, Ayat I. Ghanem, Ghada A. Omar, Mohsen M. Khalid

Journal of Medicine in Scientific Research

Introduction Genetics contribute to the development of type-2 diabetes mellitus (T2DM), its complications, and phenotypes such as diabetic nephropathy (DN) and obesity. Although the likely associations among the ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) gene, DN and obesity have been massively investigated, the results are still controversial. This study aimed to assess whether ENPP1 K121Q (A/C rs1044498) variant is associated with DN and obesity in T2DM Egyptian patients. We genotyped this variant in a total of 183 T2DM Egyptian patients who were classified into cases (91 participants with moderately increased albuminuria or severely increased albuminuria ≥ 30 mg/g) and controls …

Comment On A Case Of Positive Coronavirus Disease 2019-Infected Patient With Retinal Detachment And A Large Macular Hole: A Case Report, Pradeep K. Panigrahi

Journal of Medicine in Scientific Research

No abstract provided.

Association Of Age-Related Macular Degeneration With Prior Hyperthyroidism And Hypothyroidism: A Case-Control Study, Shih-Han Hung, Sudha Xirasagar Mbbs., Ph.D., Tung-Mei Tammy Kuang, Wei-Wen Chang, Yen-Fu Cheng, Nai-Wen Kuo, Herng-Ching Lin

Publications

Prior studies suggest a possible association between thyroid disease and the subsequent development of age-related macular degeneration (AMD), although it remains inconclusive. This study aimed to evaluate the association of AMD with prior hyper-/hypothyroidism based on nationwide population-based data. We retrieved records of the study patients from the National Health Insurance Research Database, 7522 patients with a first-time diagnosis of AMD and 7522 propensity score-matched controls. Multiple logistic regression analyses were performed to explore the association of neovascular AMD with previously diagnosed hyperthyroidism or hypothyroidism. The Chi-square test shows that there was a statistically significant difference in the prevalence of …

Reducing Immigration-Related Stress In An Immigrant Population, Stephanie Avdagic

Graduate Theses, Dissertations, and Capstones

Immigrants are a growing population in the United States and face stressors specific to immigration. Stress is associated with increased mental and physical health issues, so increased stress puts this population at risk for many health concerns. A review of literature showed that implementing community resource classes for immigrants may help decrease immigration-related stress. The purpose of this evidence-based project was to assess if implementation of community resource classes at a local day center for immigrants could help decrease immigration-related stress. The classes addressed issues such as limited English proficiency and lack of legal immigration status. The Stress of Immigration …

Association Of Age-Related Macular Degeneration With Prior Hyperthyroidism And Hypothyroidism: A Case-Control Study, Shih-Han Hung, Sudha Xirasagar, Tung-Mei Tammy Kuang, Wei-Wen Chang, Yen-Fu Cheng, Nai-Wen Kuo, Herng-Ching Lin

Faculty Publications

Prior studies suggest a possible association between thyroid disease and the subsequent development of age-related macular degeneration (AMD), although it remains inconclusive. This study aimed to evaluate the association of AMD with prior hyper-/hypothyroidism based on nationwide population-based data. We retrieved records of the study patients from the National Health Insurance Research Database, 7522 patients with a first-time diagnosis of AMD and 7522 propensity score-matched controls. Multiple logistic regression analyses were performed to explore the association of neovascular AMD with previously diagnosed hyperthyroidism or hypothyroidism. The Chi-square test shows that there was a statistically significant difference in the prevalence of …