Medicine and Health Sciences Commons^™

Pulmonary Evaluation Of Post-Covid-19 Patients: An Ecuadorian Experience, Ivan Cherrez-Ojeda, Efraín Sanchez-Angarita, Emanuel Vanegas, María José Farfán Bajaña, Karla Robles-Velasco, María F. Osorio, Azza Sarfraz, Zouina Sarfraz, Juan C. Calderón, Jorge Cáneva, Laura Gochicoa-Rangel, Matías Panchana Lascano, Juan Carlos Fernández Cadena, Derly Madeleiny Andrade Molina, Amado X Freire, Miguel Felix

Journal of Community Hospital Internal Medicine Perspectives

Background: Despite the growing concerns related to the potential of long-term pulmonary sequelae due to COVID-19, data about intermediate and long-term changes in the respiratory function of patients who recover is relatively sparse, particularly in developing countries. Objectives: To assess the characteristics and pulmonary function at follow-up in a sample of Ecuadorian patients that recovered from the virus. Methods: We conducted a cross-sectional study that included 43 patients after symptomatic COVID infection, who were evaluated by spirometry, single breath DLCO, and 6MWT. For statistical analysis we performed point biserial correlations, and chi squared tests. Results: Overall, 30.3% of patients (n=13) …

Dronedarone For Atrial Fibrillation Prophylaxis In Patients Undergoing Open Heart Surgical Interventions: A Case Series, Jay D. Patel, Mrhaf Alsamman, Dewansh Goel, Sai Gudduru, Rakesh Prashad

Journal of Community Hospital Internal Medicine Perspectives

Atrial fibrillation (a-fib) is one of the most frequently encountered and studied arrhythmias in medicine. The presence of A-fib in the post-operative period of coronary artery bypass graft (CABG) surgery is of particular concern for clinicians as this presents risks of post-operative stroke, hospital readmission, or anticoagulation dilemmas depending on the patient’s comorbidities. In this case study, we present 5 patients who were treated with dronedarone prior to undergoing open heart procedures. We subsequently followed each patients clinical course paying close attention for any evidence of post-operative a-fib.

Extranodal Rosai-Dorfman Disease- A Review Of Diagnostic Testing And Management., Imad Ud Deen, Abhinandan Chittal, Nabil Badro, Robert Jones, Christopher Haas

Journal of Community Hospital Internal Medicine Perspectives

Rosai-Dorfman disease (RDD) is a rare, benign histiocytic proliferative disorder primarily occurring in the lymph nodes. Extranodal disease can occur in skin and soft tissue, central nervous system, gastrointestinal tract, and breast. Here we present a case of a 55-year-old female with a history of hypertension, hyperlipidemia, and diabetes mellitus who presented with a fixed solid mass localized to the right medial thigh. Excision revealed S100 and CD 68 positive scattered lymphoid aggregates and emperipolesis, hallmark molecular and cytopathologic features of RDD. RDD is a nonmalignant, classically sporadic histiocytosis. Clinical outcome in terms of mortality seems to be favorable in …

Investigating The Role Of Inflammatory Markers At Admission In Defining The Severity Of Moderate-To-Critical Covid-19: A Cross-Sectional Analysis, Syed Muhammad Jawad Zaidi, Muhammad Haider Awan, Hamza Waqar Bhatti, Sania Sabir, Imran Arshad, Sualeha Ahmed, Muhammad Ali Khalid, Fazal Ur Rehman

Journal of Community Hospital Internal Medicine Perspectives

Background and Aims: The spectrum of Coronavirus disease-2019 (COVID-19) has been clinically defined from asymptomatic carriers to critical illness. Different inflammatory markers have been used to account for the severity and outcomes of this disease in different settings. Our study aims to investigate the role of these inflammatory markers in defining COVID-19 severity. Methods: This cross-sectional study included 200 confirmed cases of COVID-19. Inflammatory markers including lymphocyte count, D-Dimers, Ferritin, CRP, LDH were noted at admission. The moderate-to-critical disease was defined according to the WHO criteria. Descriptive statistics were applied. Mann-Whitney U-test was applied to compare the difference of markers …

2022-04-11 Michiganoverview_Covidoutbreak, Michigan Department Of Health & Human Services

Michigan COVID-19 Outbreak Reports

The Outbreak Data page was obtained from Michigan's COVID-19 data page: https://www.michigan.gov/coronavirus/0,9753,7-406-98163_98173_102057---,00.html.

This report is created by the Michigan Department of Health & Human Services from data self-reported by local health departments. Data is updated every week.

COVID-19 outbreaks are generally defined as two or more cases with a link by place and time indicating a shared exposure outside of a household. Local health departments report the number of new and ongoing outbreaks they are investigating by the setting of the outbreak. New outbreaks are those outbreaks that were first identified during the current reporting week. Ongoing outbreaks are …

Ada News - 04/11/2022, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Developing Evidence Based Protocols To Enhance Occupational Therapy Treatment Of The Upper Extremity, Alexandra Ross

OTD Capstone Projects

This doctoral capstone project consisted of the creation of a rehabilitation protocol booklet of 27 diagnoses pertaining to the upper extremity. This poster goes into detail of the protocol creation and development process, and provides examples of protocols for different diagnoses.

The Academic Work-Life Balance Of Entry-Level Athletic Training Students And Its Implications, Grant Pheil

School of Health and Human Performance Theses

Athletic training students (ATS) have been documented to experience stressors and perceive burnout up to this point in their assimilation into the profession. This is understood through recent work-life balance (WLB) and burnout research within the student population, stemming off research recommendations surrounding the professional setting. However, following current educational shifts and worldwide events, prior research is limited surrounding specific graduate level ATS WLB, stressors, coping responses, and comparisons across ATS demographics. The purpose of this study is to identify this balance in graduate level students and highlight stressors or management techniques that will benefit future students pursuing athletic training …

2022-04-11 Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services

Michigan COVID-19 Hospital Data

Contains the tables Statewide Hospital Capacity Report for COVID-19, COVID-19 Metrics, Statewide Hospital Available PPE Tracking for COVID-19, as well as the tables PPE Days On Hand and Patient Census.

2022-04-11_Michiganoverview_Covidschooloutbreak, Michigan Department Of Health & Human Services

Michigan COVID-19 Outbreak Reports

The School Outbreak Data page was obtained from Michigan's COVID-19 data page: https://www.michigan.gov/coronavirus/0,9753,7-406-98163_98173_102480---,00.html.

This report is created by the Michigan Department of Health & Human Services from data self-reported by local health departments. Data is updated every week.

K-12 School-Related Outbreak Reporting: In accordance with the Council of State and Territorial Epidemiologists' outbreak definition, a K-12 school-associated COVID-19 case (confirmed or probable) is defined as a student, teacher, or staff member physically present in the school setting or participated in a school sanctioned extracurricular activity within 14 days prior to illness onset (or a positive test result) OR …

Abundant Life Adventure Club Youth Program: Positive Youth Development Through Outdoor Recreation And Adventure, Gabriela Swiecki

OTD Capstone Projects

This Capstone project was completed as a collaborative effort with another OTD student and through a partnership with Abundant Life Adventure Club (ALAC). ALAC is a Nashville based organization that focuses on curating outdoor adventures and experiences for Black adults. The focus of this project was on the creation of outdoor programming for urban-dwelling youth, specifically middle schooler, using the principles of positive youth development. The result is a complete digital program guide. The guide includes objectives to address each theme, discussion questions and statements, a lesson plan template, and an activities list to pair with a theme. Using this …

Public Policy And Religion In The Pandemic: U.S. Constitution And The First Amendment, Stephen Covell, Diane Riggs, Cameron Borg

Modules for Teaching Pandemic Response and Religion in the USA

The following teaching module is designed for high school and college level instructors who seek to teach a lesson on the impact the COVID-19 pandemic had on the relationship between church and state. The teaching module features a lesson plan, case studies, and assignments that can be incorporated as the instructor sees fit. This teaching module was created by Western Michigan University's Department of Comparative Religion.

Predicting The Need For Therapeutic Intervention And Mortality In Acute Pancreatitis: A Two-Center International Study Using Machine Learning, Na Shi, Lan Lan, Jiawei Luo, Ping Zhu, Thomas R W Ward, Peter Szatmary, Robert Sutton, Wei Huang, John A Windsor, Xiaobo Zhou, Qing Xia

Faculty, Staff and Student Publications

BACKGROUND: Current approaches to predicting intervention needs and mortality have reached 65-85% accuracy, which falls below clinical decision-making requirements in patients with acute pancreatitis (AP). We aimed to accurately predict therapeutic intervention needs and mortality on admission, in AP patients, using machine learning (ML).

METHODS: Data were obtained from three databases of patients admitted with AP: one retrospective (Chengdu) and two prospective (Liverpool and Chengdu) databases. Intervention and mortality differences, as well as potential predictors, were investigated. Univariate analysis was conducted, followed by a random forest ML algorithm used in multivariate analysis, to identify predictors. The ML performance matrix was …

Occupational Therapy And Animal Assisted Therapy: Advocacy For The Field & Best Practice, Mackenzie E. Vanderbloomen

OTD Capstone Projects

There are many ways to incorporate animal assisted therapy (AAT) into occupational therapy (OT) practice, including facilitating client motivation, participation, companionship, addressing activities of daily living (ADLs) including grooming, bathing, feeding, and dressing, as well as the role of pet caretaker as an instrumental activity of daily living (IADL). While the values and goals that guide both AAT and OT seem to align in various ways, literature speaking to this unique blend of therapy and the benefits it has on client outcomes and work environment are limited. To highlight gaps in knowledge, and to inform suggestions for field advancement, a …

Peptidomics Analysis Reveals Changes In Small Urinary Peptides In Patients With Interstitial Cystitis/Bladder Pain Syndrome, Md Shadman Ridwan Abid, Haowen Qiu, Bridget A. Tripp, Aline De Lima Leite, Heidi Roth, Jiri Adamec, Robert Powers, James W. Checco

UNL Student Research Days Posters, Graduate

Interstitial cystitis or bladder pain syndrome (IC/BPS) is a chronic and debilitating pain disorder of the bladder and urinary tract with poorly understood etiology. Symptomatic criteria to aid in the diagnosis of IC/BPS includes bladder pain, an increase in urinary urgency or Hunner’s ulcers on the bladder wall.

Our study revealed differences in the profiles of small urinary peptides for IC/BPS patients compared to age-matched controls which is consistent with increased protease activity in IC/BPS. Our study also enabled the direct measurement of APF peptide abundance in IC/BPS and control urine. Our results indicate that the full-length APF peptide was …

An Imaging Biomarker Of Tumor-Infiltrating Lymphocytes To Risk-Stratify Patients With Hpv-Associated Oropharyngeal Cancer, Germán Corredor, Wade Thorstad, Et Al.

2020-Current year OA Pubs

BACKGROUND: Human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC) has excellent control rates compared to nonvirally associated OPSCC. Multiple trials are actively testing whether de-escalation of treatment intensity for these patients can maintain oncologic equipoise while reducing treatment-related toxicity. We have developed OP-TIL, a biomarker that characterizes the spatial interplay between tumor-infiltrating lymphocytes (TILs) and surrounding cells in histology images. Herein, we sought to test whether OP-TIL can segregate stage I HPV-associated OPSCC patients into low-risk and high-risk groups and aid in patient selection for de-escalation clinical trials.

METHODS: Association between OP-TIL and patient outcome was explored on whole slide …

Selective Hypermethylation Is Evident In Small Intestine Samples From Infants With Necrotizing Enterocolitis, Misty Good, Tianjiao Chu, Patricia Shaw, Lila S Nolan, Joseph Wrobleski, Carlos Castro, Qingqing Gong, Olivia Dewitt, David N Finegold, David Peters

2020-Current year OA Pubs

OBJECTIVE: Necrotizing enterocolitis (NEC) is the most common and lethal gastrointestinal disease affecting preterm infants. NEC develops suddenly and is characterized by gut barrier destruction, an inflammatory response, intestinal necrosis and multi-system organ failure. There is currently no method for early NEC detection, and the pathogenesis of NEC remains unclear.

DESIGN: To further understand the molecular mechanisms that support NEC, we used solution phase hybridization and next-generation DNA sequencing of bisulfite converted DNA to perform targeted genome-wide analysis of DNA methylation at high read depth.

RESULTS: We found that ileal samples from surgical NEC infants (n = 5) exist in …

The Use Of Mobility And Medication On Patient’S Perception Of Pain In Hospitalized Patients With Chronic Back Pain Benchmark Study, Katherine E. Zaske Merenda Mrs., Katherine Merenda

MSN Capstone Projects

According to Boss & Huether, twenty-nine percent of Americans have been diagnosed with chronic low back pain (CLBP). This pain can affect every part of their lives leading to lost wages and decreased quality of life. CLBP is an issue experienced by many hospitalized patients. These patients may not be able to mitigate their pain as they normally would due to safety protocols in hospital settings. Exercise or mobility has been shown to decrease a person’s perception of pain. The importance of exercise and mobility in a hospital setting to help decrease a patient’s perception of pain needs further research. …

Resiliency Storyboard: Learn From Mistakes, Collin Gustafson, Adlai Nelson, Matthew Myhand, Arsh Kaiser, Erin Madden, Chelsea Yu

Patient Education Projects

No abstract provided.

Resiliency Storyboard: Procrastination, Sarah Bassett, Kristofer Hilliard, Karis Tutuska, Allen Zhang, Daniel Domin, Varsha Kumar

Patient Education Projects

No abstract provided.

Resiliency Storyboard: Mental Fatigue, Enoch Kim, Lauren Larson, Shagane Kotcharian, Sadie Knill, Alejandro Ponce Sepulveda, Doo Hee Kim

Patient Education Projects

No abstract provided.

Molecular Characterization Of Rickettsial Agents In Ticks (Acari: Ixodidae) From Sri Lanka, Gregory A. Dasch, Marina Eremeeva, Maria L. Zambrano, Ranjan Premaratna, S. A. M. Kularatne

Biostatistics, Epidemiology & Environmental Health Sciences: Faculty Publications

Because the majority of spotted fever group rickettsiae are transmitted to humans by tick bites, it is important to understand which ticks might play a role in transmission of rickettsial pathogens in Sri Lanka. The purpose of our study was to conduct molecular surveillance of 847 ticks collected in different locations in central Sri Lanka to determine which were infected with Rickettsia and Anaplasmataceae. Molecular methods were used to identify the ticks and the agents detected. Most ticks (Amblyomma, Haemaphysalis, and Rhipicephalus) were collected by flagging, and lower number was collected from dogs, cattle, pigs, a …

Improving Occupational Engagement: An Occupation-Based Virtual Program For Caregivers Of Individuals With Dementia, Betsabel Garcia, Pam Kasyan-Howe, Kristin Domville, Lisa Schubert

Spring 2022 Virtual OTD Capstone Symposium

Dementia is a progressive disorder that affects many people worldwide including informal caregivers of individuals with dementia (Harrison et al., 2019). Every year, more than 16 million Americans provide more than 17 billion hours of unpaid care for family and friends with Alzheimer’s disease or other related dementias (CDC, 2019). As a result, many informal caregivers experience higher levels of caregiver burden, depression, and anxiety (Amato et al., 2021; Raj et al., 2021; Walter & Pinquart, 2020). This causes an occupational imbalance in caregivers' ability to meet their needs and those of their loved one. Leisure is within occupational therapy's …

Characterisation Of Drug-Resistant Mycobacterium Tuberculosis Mutations And Transmission In Pakistan, Gary Napier, Anwar Sheed Khan, Abdul Jabbar, Muhammad Tahir Khan, Sajid Ali, Muhammad Qasim, Noor Mohammad, Rumina Hasan, Zahra Hasan, Susana Campino

Department of Pathology and Laboratory Medicine

Tuberculosis, caused by Mycobacterium tuberculosis, is a high-burden disease in Pakistan, with multi-drug (MDR) and extensive-drug (XDR) resistance, complicating infection control. Whole genome sequencing (WGS) of M. tuberculosis is being used to infer lineages (strain-types), drug resistance mutations, and transmission patterns-all informing infection control and clinical decision making. Here we analyse WGS data on 535 M. tuberculosis isolates sourced across Pakistan between years 2003 and 2020, to understand the circulating strain-types and mutations related to 12 anti-TB drugs, as well as identify transmission clusters. Most isolates belonged to lineage 3 (n = 397; 74.2%) strain-types, and were MDR (n = …

Machine Learning Based Medical Image Deepfake Detection: A Comparative Study, Siddharth Solaiyappan, Yuxin Wen

Engineering Faculty Articles and Research

Deep generative networks in recent years have reinforced the need for caution while consuming various modalities of digital information. One avenue of deepfake creation is aligned with injection and removal of tumors from medical scans. Failure to detect medical deepfakes can lead to large setbacks on hospital resources or even loss of life. This paper attempts to address the detection of such attacks with a structured case study. Specifically, we evaluate eight different machine learning algorithms, which include three conventional machine learning methods (Support Vector Machine, Random Forest, Decision Tree) and five deep learning models (DenseNet121, DenseNet201, ResNet50, ResNet101, VGG19) …

A Scoping Review: Trauma Informed Care For Justice Involved Youth To Decrease Recidivism, Tamika Beecham, Marissa Gray, Shelby Husband, Diana Dedmon Dnp, Fnp, Bc

Doctor of Nursing Practice Projects

Purpose The purpose of this scoping review was to address trauma-informed care, juvenile justice systems, and recidivism rates. The literature review conducted identified key research and analysis of effective trauma-informed treatment methodologies, referrals, and accessibility of care for justice-involved youth, and the rate change of recidivism related to trauma-informed treatment and interventions.

Background The high rates of recidivism in the juvenile court systems matched with the increased prevalence of psychological trauma in justice-involved youth represent the need for implementing trauma informed care. The scoping review analyzed the research implementing the intervention of trauma informed care to determine if it resulted …

An Imaging Biomarker Of Tumor-Infiltrating Lymphocytes To Risk-Stratify Patients With Hpv-Associated Oropharyngeal Cancer, Germán Corredor, Paula Toro, Can Koyuncu, Cheng Lu, Christina Buzzy, Kaustav Bera, Pingfu Fu, Mitra Mehrad, Kim A Ely, Mojgan Mokhtari, Kailin Yang, Deborah Chute, David J Adelstein, Lester D R Thompson, Justin A Bishop, Farhoud Faraji, Wade Thorstad, Patricia Castro, Vlad Sandulache, Shlomo A Koyfman, James S Lewis, Anant Madabhushi

Faculty, Staff and Students Publications

BACKGROUND: Human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC) has excellent control rates compared to nonvirally associated OPSCC. Multiple trials are actively testing whether de-escalation of treatment intensity for these patients can maintain oncologic equipoise while reducing treatment-related toxicity. We have developed OP-TIL, a biomarker that characterizes the spatial interplay between tumor-infiltrating lymphocytes (TILs) and surrounding cells in histology images. Herein, we sought to test whether OP-TIL can segregate stage I HPV-associated OPSCC patients into low-risk and high-risk groups and aid in patient selection for de-escalation clinical trials.

METHODS: Association between OP-TIL and patient outcome was explored on whole slide …

Ndrg1 In Aggressive Breast Cancer Progression And Brain Metastasis, Emilly S Villodre, Xiaoding Hu, Bedrich L Eckhardt, Richard Larson, Lei Huo, Ester C Yoon, Yun Gong, Juhee Song, Shuying Liu, Naoto T Ueno, Savitri Krishnamurthy, Stefan Pusch, Debu Tripathy, Wendy A Woodward, Bisrat G Debeb

Faculty, Staff and Student Publications

BACKGROUND: N-Myc downstream regulated gene 1 (NDRG1) suppresses metastasis in many human malignancies, including breast cancer, yet has been associated with worse survival in patients with inflammatory breast cancer. The role of NDRG1 in the pathobiology of aggressive breast cancers remains elusive.

METHODS: To study the role of NDRG1 in tumor growth and brain metastasis in vivo, we transplanted cells into cleared mammary fat pads or injected them in tail veins of SCID/Beige mice (n = 7-10 per group). NDRG1 protein expression in patient breast tumors (n = 216) was assessed by immunohistochemical staining. Kaplan-Meier method with 2-sided log-rank test …

Resiliency Storyboard: Developing Mental Endurance, Saranya Madan, Erin Bybee, Mehrnoosh Ghafouri Abbasabadi, Madison Graifman, Isaiah Hough, Chase Morrison

Patient Education Projects

No abstract provided.

Resiliency Storyboard: Finding What Works Best For You, Emma Streveler, Rooshan Arshad, Riya Shah, John Lloyd, Mackenzie Howard, Joseph Cavataio

Patient Education Projects

No abstract provided.