Medicine and Health Sciences Commons^™

Clarifying Mixed Methodology In Occupational Therapy Research, Kristin A. Winston, Diane Powers Dirette

The Open Journal of Occupational Therapy

No abstract provided.

Degradation Of Vitamin E Acetate Through Vaping Produces Byproducts Cytotoxic To Thp-1 Monocytic Cells, Joshua Alcon

Pharmaceutical Sciences ETDs

Electronic cigarette or vaping use associated lung injury (EVALI) is a pulmonary disease among those who vaped illicit tetrahydrocannabinol (THC) cartridges that resulted in hospitalization or death. Vitamin E acetate (VEA) was a common additive present in the bronchioalveolar lavage fluid (BALF) of patients who were hospitalized with EVALI. However, little is known about pulmonary exposure to vitamin E acetate (VEA) when inhaled through vaping. The hypothesis of this study is the cytotoxicity of vaped VEA is due, at least in part, to the pyrolytic breakdown products of VEA produced by vaping, as opposed to VEA itself. From this study, …

Adult Program Development Gigi’S Playhouse, Ella E. Baggett

OTD Capstone Projects

This capstone experience was conducted through partnership with GiGi’s Playhouse Nashville, a Down-syndrome achievement center that provides free educational, therapeutic-based and career development programs for individuals with Down syndrome, their families, and the community. This experience primarily focused on piloting the GiGi University program through an occupational lens by adapting, modifying, and implementing national curriculum to meet student needs. GiGi U sought to increase confidence, career skills, personal wellness, and overall quality of life. Additionally, training and support was provided to GiGi’s satellite location in a neighboring county to increase sustainability of additional programming.

Implementation Of A Readiness Model For Kidney Transplant Patients, Shelby Mcdonnell, John Vella, Ardyce Peters

Costas T. Lambrew Research Retreat 2022

Increasing Access to Kidney Transplantation: How Decreasing Time in Transplant Evaluation Led to More Timely Eligibility for Organ Offers

Decreasing Central Venous Catheter Usage For The Hemodialysis Patient, Antionette Jordan

Dissertations

Abstract

Problem: The central venous catheter (CVC) usage rate in a large urban dialysis clinic was 34.5% and the Centers for Medicaid and Medicare Services (CMS) goal is 10.7%. CVC usage is a quality metric monitored by CMS to assess whether dialysis facilities are providing quality services which can impact reimbursement for the clinic. Failure to meet this metric can result in a penalty of up to 2% in reimbursement. The purpose of this quality improvement project was to determine if an interdisciplinary team (IDT) approach to vascular access planning and care influenced the CVC usage rate by 10% …

2022-04-15 Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services

Michigan COVID-19 Hospital Data

Contains the tables Statewide Hospital Capacity Report for COVID-19, COVID-19 Metrics, Statewide Hospital Available PPE Tracking for COVID-19, as well as the tables PPE Days On Hand and Patient Census.

The Current State Of Subjective Training Load Monitoring: Follow-Up And Future Directions, Joseph O. C. Coyne, Aaron J. Coutts, Robert U. Newton, Gregory G. Haff

Research outputs 2022 to 2026

This article addresses several key issues that have been raised related to subjective training load (TL) monitoring. These key issues include how TL is calculated if subjective TL can be used to model sports performance and where subjective TL monitoring fits into an overall decision-making framework for practitioners. Regarding how TL is calculated, there is conjecture over the most appropriate (1) acute and chronic period lengths, (2) smoothing methods for TL data and (3) change in TL measures (e.g., training stress balance (TSB), differential load, acute-to-chronic workload ratio). Variable selection procedures with measures of model-fit, like the Akaike Information Criterion, …

A Peer-Led Evidence-Based Contraceptive Counseling Initiative, Megan K. Tenbarge

DNP Projects

The experience of sexual health and wellness varies for newly independent college freshman. For reproductive-age women, gaps in knowledge and self-efficacy overlap with barriers accessing contraception and reproductive health care contributing to high-risk behavior and poor sexual health outcomes. Community-based participatory research was used to develop and implement a peer-education program targeting sorority women on a college campus in the Southeastern United States in the fall semester of 2021. Two senior nursing majors completed continuing education to be empowered as peer-educators using The University of California San Francisco Beyond the Pill framework. They engaged directly with nursing faculty stakeholders and …

New-Onset Acute Ischemic Stroke Following Covid-19: A Case-Control Study, Fariborz Khorvash, Mohammad Amin Najafi, Mohsen Kheradmand, Mohammad Saadatnia, Rojin Chegini, Farideh Najafi

Rothman Institute Papers

Background: Neurological manifestations of coronavirus disease 2019 (COVID-19) have been highlighted. COVID-19 potentially increases the risk of thromboembolism. We aimed to compare patients with COVID-19 with and without new-onset acute ischemic stroke (AIS).

Materials and methods: In this single-center retrospective case-control study, demographics, clinical characteristics, laboratory findings, and clinical outcomes were compared between 51 patients with both COVID-19 and AIS (group A) and 160 patients with COVID-19 and without AIS (group B).

Results: Patients in group A were significantly older, more likely to present with critical COVID-19 (P = 0.004), had higher rates of admission in the intensive care …

Optimizing The Performance And Treatment Of The Female Athlete, Sommer Hammoud, Robin V. West

Department of Orthopaedic Surgery Faculty Papers

No abstract provided.

Social Capital, Urbanization Level, And Covid-19 Vaccination Uptake In The United States: A National Level Analysis, Shan Qiao, Zhenlong Li, Jiajia Zhang, Xiaowen Sun, Camryn Garrett, Xiaoming Li

Faculty Publications

Vaccination remains the most promising mitigation strategy for the COVID-19 pandemic. However, existing literature shows significant disparities in vaccination uptake in the United States. Using publicly available national-level data, we aimed to explore if county-level social capital can further explain disparities in vaccination uptake rates when adjusting for demographic and social determinants of health (SDOH) variables, and if association between social capital and vaccination uptake may vary by urbanization level. Bivariate analyses and a hierarchical multivariable quasi-binomial regression analysis were conducted, where the regression analysis was stratified by urban–rural status. The current study suggests that social capital contributes significantly to …

Somatic Dnmt3a Inactivation Leads To Slow, Canonical Dna Methylation Loss In Murine Hematopoietic Cells, Amanda M. Smith, Angela M. Verdoni, Haley J. Abel, David Y. Chen, Shamika Ketkar, Elizabeth R. Leight, Christopher A. Miller, Timothy J. Ley

2020-Current year OA Pubs

Mutations in the gene encoding DNA methyltransferase 3A (

Anatomical Variability, Multi-Modal Coordinate Systems, And Precision Targeting In The Marmoset Brain, Takayuki Ose, David C Van Essen, Matthew F Glasser, Et Al.

2020-Current year OA Pubs

Localising accurate brain regions needs careful evaluation in each experimental species due to their individual variability. However, the function and connectivity of brain areas is commonly studied using a single-subject cranial landmark-based stereotactic atlas in animal neuroscience. Here, we address this issue in a small primate, the common marmoset, which is increasingly widely used in systems neuroscience. We developed a non-invasive multi-modal neuroimaging-based targeting pipeline, which accounts for intersubject anatomical variability in cranial and cortical landmarks in marmosets. This methodology allowed creation of multi-modal templates (MarmosetRIKEN20) including head CT and brain MR images, embedded in coordinate systems of anterior and …

Nuclear Morphometry And Chromatin Texture Changes In Hepatocellular Carcinoma Samples May Predict Outcomes Of Liver Transplanted Patients, Jordan Boeira Dos Santos, Rodrigo Tzovenos Starosta, Emily Ferreira Salles Pilar, Jefferson Daniel Kunz, Joelson Tomedi, Carlos Thadeu Schmidt Cerski, Rúbia Denise Ruppenthal

2020-Current year OA Pubs

BACKGROUND: Nuclear changes are typical in the carcinogenesis of hepatocellular carcinoma (HCC). Morphometry and chromatin texture analysis are quantitative methods for their quantification. In this study, we analyzed nuclear morphometry and chromatin texture parameters in samples of hepatocellular carcinoma from liver transplant patients and their associations with clinicopathologic variables.

METHODS: Samples of HCC and adjacent tissue from 34 individuals were collected in tissue microarray blocks. Stained slides were microphotographed using an optical microscope and nuclear parameters analyzed in ImageJ (FracLac plug-in). ROC curve analysis was used to find accurate cut-offs for differentiation of neoplastic and non-neoplastic cells. The inter-rater agreement …

Heat-Induced Sirt1-Mediated H4k16ac Deacetylation Impairs Resection And Smarcad1 Recruitment To Double Strand Breaks, Sharmistha Chakraborty, Raj K. Pandita, Nobuo Horikoshi, Eduardo G Moros, Clayton Hunt, Tej K. Pandita, Et Al.

2020-Current year OA Pubs

Hyperthermia inhibits DNA double-strand break (DSB) repair that utilizes homologous recombination (HR) pathway by a poorly defined mechanism(s); however, the mechanisms for this inhibition remain unclear. Here we report that hyperthermia decreases H4K16 acetylation (H4K16ac), an epigenetic modification essential for genome stability and transcription. Heat-induced reduction in H4K16ac was detected in humans,

Do We Trust The Government? Attributes Of Covid-19 Vaccine Hesitancy And Acceptance In Nigeria, Osmond C. Ekwebelem, Helen Onyeaka, Ismaeel Yunusa Ph. D., Taghi Miri, Yahwedalu M. Onwuneme, Ayeni T. Eunice, Amara Anyogu, Bright Obi, Ngwogu Ada Carol

Faculty Publications

Objectives:

A significant percentage of the population must be vaccinated to achieve herd immunity. Therefore the success of a vaccination program relies on the level of acceptance. This present study seeks to understand COVID-19 vaccine acceptance and hesitancy in Nigeria by assessing the public's willingness to get vaccinated.

Study design:

This is a population-based cross-sectional study. Data were derived through a structured online survey.

Methods:

A cross-sectional study was conducted among adult residents in Nigeria in March 2021 using a structured online questionnaire. The questionnaire surveyed participants' demographic characteristics and perception of COVID-19 and the COVID-19 vaccine. Descriptive statistics and …

Understanding Factors Associated With Clinician Confidence To Identify And Treat Ptsd And Complex Ptsd, Parad Meier

Counseling and Psychology Dissertations

ABSTRACT

This dissertation explores mental health clinicians’ experiences and self-identified confidence to identify and treat post-traumatic stress disorder (PTSD) and Complex PTSD. PTSD is a highly prevalent mental health condition that impacts an estimated 24.4 million individuals in the United States (PTSD United, 2019). Complex PTSD has just emerged for the first time with official diagnostic criteria in the publication of the ICD-11 in 2019 for use beginning in January 2022 (WHO, 2019). There is very little existing research that considers the experience or confidence of clinicians who work with clients who have PTSD and Complex PTSD, which is troubling …

Acute Lower Extremity Posterior Compartment Syndrome: A Rare Complication Of Apixaban Use, Jennifer Adams, Jose H. Ramos, Shyama Appareddy M.D., Hoang Anh Thi Nguyen, Gustavo Garcia

School of Medicine Publications

Apixaban is an oral anticoagulant that directly inhibits Factor Xa and is indicated for the prophylaxis and treatment of deep venous thrombosis and stroke prevention in non-valvular atrial fibrillation. Acute lower extremity Posterior Compartment Syndrome is a rare complication of Apixaban use. We present a 78-year-old male with significant medical morbidities taking Apixaban for Atrial Fibrillation presenting with post-traumatic extensive hemorrhagic bullae on the left proximal pretibial region secondary to anticoagulation. We recommend that clinicians develop awareness of the potential for serious bleeding complications of anticoagulants and devise strategies to identify the need for early recognition and prompt management.

Illuminate Academy Shine Shop Resources And Kindergarten Market Research, Rya G. Carroll

OTD Capstone Projects

This capstone project was completed through a partnership with Illuminate Academy in Nashville, Tennessee. Illuminate Academy is a not-for-profit alternative to public or private school for children with Autism and developmental disabilities. The primary focus of this capstone project was to develop a resource guide for the Shine Shop, a transition program that provides students of Illuminate Academy an opportunity to give back to the community through dignified activities. The deliverable included task analyses of sold products, supply lists, and visual supports for learners. The resource guide was developed to ensure sustainability of the Shine Shop products, as well as …

Decreased Physical Activity Among Youth Resulting From Covid-19 Pandemic-Related School Closures: Natural Experimental Study., Amanda Grimes, Joseph S. Lightner, Katlyn Eighmy, Chelsea Steel, Robin P. Shook, Jordan A. Carlson

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: The COVID-19 pandemic has resulted in the closure of schools and may have inadvertently resulted in decreased physical activity for youth. Emerging evidence suggests that school closures due to the COVID-19 pandemic could have hastened the inactivity of youth, possibly due to a lack of structure outside of school and increased access to sedentary activities.

OBJECTIVE: The purpose of this study was to assess changes in physical activity from pre-school closure (before the pandemic) to post-school closure (during the pandemic) among youth in spring 2020.

METHODS: This study used a natural experimental design; youth were enrolled in a physical …

Teaching Dna Extractions From Fruits (Strawberry, Banana, Kiwi, And Watermelon), Amadea Pourier, Dillon Nelson, Wiyaka Pomarleau, Kay Cutler, Madhav P. Nepal

iLEARN Teaching Resources

In this lesson, students will use a simple DNA extraction solution and isopropyl alcohol to extract DNA from strawberries, banana, kiwi, and watermelon. The extraction solution consists of dish detergent, water, and table salt. Grinding or crushing the soft fruit tissue will separate the cells. The dish detergent breaks down the membranes, exposing the DNA to the solution. The salt helps the DNA molecule to stick together from the proteins. The cold alcohol dissolves everything but the DNA, which forms an insoluble layer of the DNA allowing it to be visible.

Actl6a Coordinates Axonal Caliber Recognition And Myelination In The Peripheral Nerve, Hye-Jin Park, Eric Tsai, Dennis Huang, Michael Weaver, Luciana Frick, Ace Alcantara, John J. Moran, Julia Patzig, Carmen V. Melendez-Vasquez, Gerald R. Crabtree, M.L. Feltri, John Svaren, Patricia Casaccia

Advanced Science Research Center

Cells elaborate transcriptional programs in response to external signals. In the peripheral nerves, Schwann cells (SC) sort axons of given caliber and start the process of wrapping their membrane around them. We identify Actin-like protein 6a (ACTL6a), part of SWI/SNF chromatin remodeling complex, as critical for the integration of axonal caliber recognition with the transcriptional program of myelination. Nuclear levels of ACTL6A in SC are increased by contact with large caliber axons or nanofibers, and result in the eviction of repressive histone marks to facilitate myelination. Without Actl6a the SC are unable to coordinate caliber recognition and myelin production. Peripheral …

A Just-In-Time Video Primer On Pneumothorax Pathophysiology And Early Management, Nicholas Macdonald, Jacob Garcia, Gregory C. Kane, Xiao Chi Zhang, Dimitrios Papanagnou

Department of Emergency Medicine Faculty Papers

Audience: Emergency medicine residents (interns, junior residents), medical students, and mid-level providers (physician assistants, nurse practitioners).

Introduction: Pneumothorax refersto the presence of gas within the pleuralspace and is a relatively common clinical entity in the emergency department Traumatic pneumothorax results from blunt or penetrating trauma to the thorax. Iatrogenic pneumothorax is a risk inherent to a number of invasive procedures and represents a significant cause of preventable morbidity. Specifically, central venous catheterization (43.8%), thoracentesis (20.1%), and barotrauma due to mechanical ventilation (9.1%) are the most frequent causes. A feared complication of pneumothorax is the development of tension pneumothorax, which involves …

Healthcare Expenditure Associated With Polypharmacy In Older Adults With Cardiovascular Diseases, Min Ji Kwak, Mihyun Chang, Simbo Chiadika, David Aguilar, Elenir Avritscher, Ashish Deshmukh, Parag Goyal, Dae Hyun Kim, Rajender Aparasu, Holly M Holmes

Faculty, Staff and Student Publications

No abstract provided.

Outcomes Of A Covid Mobility Team, Kellie Girardot Msn, Rn, Leann Pancake Mpt, Pt

Nursing Publications, Posters, & Presentations

The detrimental effects of immobility are well documented in the literature, yet immobility still plagues the hospitalized adult. As the influx of COVID-19 patients began, patient mobility was further compromised. The purpose of this quality improvement project was to assess the impact of COVID mobility teams, composed of deployed coworkers, on COVID-19–positive and person under investigation patient outcomes. Using mobility teams improved mobility in COVID-positive and person under investigation patients. Increasing patient mobility results in improved patient outcomes by preventing hospital-acquired functional decline, preventing intensive care unit transfers, and decreasing length of stay.

Computer Simulations And Network-Based Profiling Of Binding And Allosteric Interactions Of Sars-Cov-2 Spike Variant Complexes And The Host Receptor: Dissecting The Mechanistic Effects Of The Delta And Omicron Mutations, Gennady M. Verkhivker, Steve Agajanian, Ryan Kassab, Keerthi Krishnan

Mathematics, Physics, and Computer Science Faculty Articles and Research

In this study, we combine all-atom MD simulations and comprehensive mutational scanning of S-RBD complexes with the angiotensin-converting enzyme 2 (ACE2) host receptor in the native form as well as the S-RBD Delta and Omicron variants to (a) examine the differences in the dynamic signatures of the S-RBD complexes and (b) identify the critical binding hotspots and sensitivity of the mutational positions. We also examined the differences in allosteric interactions and communications in the S-RBD complexes for the Delta and Omicron variants. Through the perturbation-based scanning of the allosteric propensities of the SARS-CoV-2 S-RBD residues and dynamics-based network centrality and …

Time Dependent Analysis Of Rat Microglial Surface Markers In Traumatic Brain Injury Reveals Dynamics Of Distinct Cell Subpopulations, Assaf Gottlieb, Naama Toledano-Furman, Karthik S Prabhakara, Akshita Kumar, Henry W Caplan, Supinder Bedi, Charles S Cox, Scott D Olson

Faculty, Staff and Student Publications

Traumatic brain injury (TBI) results in a cascade of cellular responses, which produce neuroinflammation, partly due to the activation of microglia. Accurate identification of microglial populations is key to understanding therapeutic approaches that modify microglial responses to TBI and improve long-term outcome measures. Notably, previous studies often utilized an outdated convention to describe microglial phenotypes. We conducted a temporal analysis of the response to controlled cortical impact (CCI) in rat microglia between ipsilateral and contralateral hemispheres across seven time points, identified microglia through expression of activation markers including CD45, CD11b/c, and p2y12 receptor and evaluated their activation state using additional …

Classification Of Human Chronic Inflammatory Skin Disease Based On Single-Cell Immune Profiling, Yale Liu, Hao Wang, Mark Taylor, Christopher Cook, Alejandra Martínez-Berdeja, Jeffrey P North, Paymann Harirchian, Ashley A Hailer, Zijun Zhao, Ruby Ghadially, Roberto R Ricardo-Gonzalez, Roy C Grekin, Theodora M Mauro, Esther Kim, Jaehyuk Choi, Elizabeth Purdom, Raymond J Cho, Jeffrey B Cheng

Staff and Researcher Publications

Inflammatory conditions represent the largest class of chronic skin disease, but the molecular dysregulation underlying many individual cases remains unclear. Single-cell RNA sequencing (scRNA-seq) has increased precision in dissecting the complex mixture of immune and stromal cell perturbations in inflammatory skin disease states. We single-cell-profiled CD45+ immune cell transcriptomes from skin samples of 31 patients (7 atopic dermatitis, 8 psoriasis vulgaris, 2 lichen planus (LP), 1 bullous pemphigoid (BP), 6 clinical/histopathologically indeterminate rashes, and 7 healthy controls). Our data revealed active proliferative expansion of the Treg and Trm components and universal T cell exhaustion in human rashes, with a relative …

Health Disparities In Minority Populations, Samuel Keirsey, Struti Patel, Madison Ray

Epsilon Sigma at-Large Research Conference

Abstract

Introduction and Background: Minority populations struggle to gain access to equitable healthcare due to cultural variations and language barriers. It is paramount for providers to accommodate to the differing needs of underserved minority groups.

Purpose Statement: We analyzed information on the effects of community-based interventions aimed at improving healthcare access for minorities.

Literature Review: We used PubMed as our main database. For our search, we looked up the keywords “Healthcare Access AND Minorities.” Next, we filtered articles that had been published since 2017 and sorted to include clinical trials, randomized control trials, and meta-analyses. After that, we came across …

Non-Pharmacological Interventions For Fatigue In Lung Cancer Patients, Sydney Robey, Micah Stewart, Melody Trickett

Epsilon Sigma at-Large Research Conference

Abstract

Introduction & Background: One of the most common and debilitating side effects of cancer is fatigue. Fatigue is a general feeling of tiredness or weakness that can greatly impact a patient’s quality of life. It can have a profound impact on a patient’s ability to perform day to day activities and cause emotional distress leading to anxiety and depression. In recent years, there has been an increase in research to look at the effectiveness of non-pharmacological interventions on improving cancer patients’ fatigue.

Purpose Statement: The purpose of our research is to look at the effectiveness of different types of …