Medicine and Health Sciences Commons^™

Plant Growth And Phytoactive Alkaloid Synthesis In Kratom [Mitragyna Speciosa (Korth.)] In Response To Varying Radiance, Mengzi Zhang, Abhisheak Sharma, Francisco León Ph.D., Bonnie Avery, Roger Kjelgren, Christopher R. Mccurdy, Brian J. Pearson

Faculty Publications

Leaves harvested from kratom [Mitragyna speciosa (Korth.)] have a history of use as a traditional ethnobotanical medicine to combat fatigue and improve work productivity in Southeast Asia. In recent years, increased interest in the application and use of kratom has emerged globally, including North America, for its potential application as an alternative source of medicine for pain management and opioid withdrawal syndrome mitigation. Although the chemistry and pharmacology of major kratom alkaloids, mitragynine and 7-hydroxymitragynine, are well documented, foundational information on the impact of plant production environment on growth and kratom alkaloids synthesis is unavailable. To directly address this need, …

Impact Of Mass Distribution Of Insecticide-Treated Nets In Mozambique, 2012 To 2025: Estimates Of Child Lives Saved Using The Lives Saved Tool, Erica Wetzler, Chulwoo Park, Jorge A. H. Arroz, Marta Chande, Figueiredo Mussambala, Baltazar Candrinho

Faculty Research, Scholarly, and Creative Activity

Malaria was the leading cause of post-neonatal deaths in Mozambique in 2017. The use of insecticide treated nets (ITNs) is recognized as one of the most effective ways to reduce malaria mortality in children. No previous analyses have estimated changes in mortality attributable to the scale-up of ITNs, accounting for provincial differences in mortality rates and coverage of health interventions. Based upon annual provincial ownership coverage of ITNs, the Lives Saved Tool (LiST), a multi-cause mathematical model, estimated under-5 lives saved attributable to increased household ITN coverage in 10 provinces of Mozambique between 2012 and 2018, and projected lives saved …

A Periplasmic Cinched Protein Is Required For Siderophore Secretion And Virulence Of Mycobacterium Tuberculosis., Lei Zhang, James E Kent, Meredith Whitaker, David C Young, Dominik Herrmann, Alexander E Aleshin, Ying-Hui Ko, Gino Cingolani, Jamil S Saad, D Branch Moody, Francesca M Marassi, Sabine Ehrt, Michael Niederweis

Department of Biochemistry and Molecular Biology Faculty Papers

Iron is essential for growth of Mycobacterium tuberculosis, the causative agent of tuberculosis. To acquire iron from the host, M. tuberculosis uses the siderophores called mycobactins and carboxymycobactins. Here, we show that the rv0455c gene is essential for M. tuberculosis to grow in low-iron medium and that secretion of both mycobactins and carboxymycobactins is drastically reduced in the rv0455c deletion mutant. Both water-soluble and membrane-anchored Rv0455c are functional in siderophore secretion, supporting an intracellular role. Lack of Rv0455c results in siderophore toxicity, a phenotype observed for other siderophore secretion mutants, and severely impairs replication of M. tuberculosis in mice, demonstrating …

Anti‐Cd20 Therapeutic Options In Immune‐Mediated Thrombotic Thrombocytopenic Purpura, Robert W. Maitta

Faculty Scholarship

Immunosuppression with rituximab in immune-mediated thrombotic thrombocytopenic purpura helps decrease production of autoantibody mediating ADAMTS13 clearance from circulation. Failure to respond to rituximab in a satisfactory way or made difficult by adverse events to the medication does not represent a reason to stop considering anti-CD20 therapies to control antibody production. Therefore, both of atumumab and obinutuzumab with specificity to CD20, represent potentially valuable therapeutic tools in patients who are not candidates for rituximab. Commentary on: Doyle et al. The use of obinutuzumab and ofatumumab in the treatment of immune thrombotic thrombocytopenic purpura. Br J Haematol. 2022;198:391-396.1.

Future Of Biomedical, Agricultural, And Biological Systems Research Using Domesticated Animals, Thomas E Spencer, Kevin D Wells, Kiho Lee, Bhanu P Telugu, Peter J Hansen, Frank F Bartol, Leann Blomberg, Lawrence B Schook, Harry Dawson, Joan K Lunney, John P Driver, Teresa A Davis, Sharon M Donovan, Ryan N Dilger, Linda J Saif, Adam Moeser, Jodi L Mcgill, George Smith, James J Ireland

Children’s Nutrition Research Center Staff Publications

Increased knowledge of reproduction and health of domesticated animals is integral to sustain and improve global competitiveness of U.S. animal agriculture, understand and resolve complex animal and human diseases, and advance fundamental research in sciences that are critical to understanding mechanisms of action and identifying future targets for interventions. Historically, federal and state budgets have dwindled and funding for the United States Department of Agriculture (USDA) National Institute of Food and Agriculture (NIFA) competitive grants programs remained relatively stagnant from 1985 through 2010. This shortage in critical financial support for basic and applied research, coupled with the underappreciated knowledge of …

Is The Zebrafish Speed Bump Mutant A Mutation In Wee1? And Is It A Complete Loss Of Function?, Nathania Karyadi

Honors Theses

Every cell has to undergo the cell cycle process before it can divide or differentiate. The cell cycle is an error-prone complex process where mutations could happen. This study aimed to characterize the nervous system and blood cells of the speed bump mutant in zebrafish. This study also aimed to do gene characterization of the wee1 CRISPR mutant. The speed bump mutant is due to a mutation in the wee1 gene. Lack of the wee1 gene will cause no Wee1 Kinase, which inhibits the MPF, causing cells to go into mitosis too early. To fulfill these objectives, this study used …

Exploring Arts Based Assessments For Relevancy In Art Therapy Research, Anjelica Cortés, Denielle Dominguez, Hayoung Lee, Naomi Nessim, Ciera D. Olson

LMU Theses and Dissertations

This paper explores the integration of art assessments with cancer patients as a tool for determining potential scholarly value. Qualitative data was collected from two clinicians who ran weekly art therapy groups with women who are undergoing or who have survived breast cancer treatment. Both groups were 10 week modules structured as open studio groups, and each clinician was subsequently interviewed by the researchers who used a series of formatted questions to assess how the four art assessments were offered to participants, how participants responded to the invitation to engage in assessments, and how the clinician’s reflected on patients’ experiences …

Effect Of Lipid-Lowering Medications In Patients With Coronary Artery Bypass Grafting Surgery Outcomes, Chunxia Shi, Zugui Zhang, Jordan E Goldhammer, David Li, Bob Kiaii, Victor Rudriguez, Douglas Boyd, David Lubarsky, Richard Applegate, Hong Liu

Department of Anesthesiology Faculty Papers

Background: Increased life expectancy and improved medical technology allow increasing numbers of elderly patients to undergo cardiac surgery. Elderly patients may be at greater risk of postoperative morbidity and mortality. Complications can lead to worsened quality of life, shortened life expectancy and higher healthcare costs. Reducing perioperative complications, especially severe adverse events, is key to improving outcomes in patients undergoing cardiac surgery. The objective of this study is to determine whether perioperative lipid-lowering medication use is associated with a reduced risk of complications and mortality after coronary artery bypass grafting (CABG) with cardiopulmonary bypass (CPB).

Methods: After IRB approval, we …

Home-Grown School Feeding: Implementation Lessons From A Pilot In A Poor Ethnic Minority Community In Vietnam, Sabina Di Prima, Dai Nguyen Dinh, Demi D. Reurings, E Pamela Wright Phd, Ms, Med, Rn, Cen, Dirk Essink, Jacqueline E. Broerse

Publications

BACKGROUND:

Undernutrition threatens the health and future of preschool children in disadvantaged remote communities. Home-grown school feeding (HGSF) in nursery schools could positively impact children's nutrition while creating multiple benefits for the whole community. However, evidence is lacking on implementation of HGSF within multi-sectoral programs in remote areas.

OBJECTIVE:

This study assessed an HGSF pilot intervention, part of a nutrition-sensitive agriculture (NSA) program, in a mountain ethnic minority community in Vietnam. It aimed to identify the changes brought about by the intervention, in particular diversity of children's food, food sources, barriers and facilitators to change, and future challenges and strategies. …

Antiviral Activity Of Olanexidine-Containing Hand Rub Against Human Noroviruses, Akifumi Hagi, Frederick H Neill, Robert L Atmar, B V Venkataram Prasad, Mary K Estes

Faculty, Staff and Students Publications

Human norovirus (HuNoV) is the leading cause of epidemic and sporadic acute gastroenteritis worldwide. HuNoV transmission occurs predominantly by direct person-to-person contact, and its health burden is associated with poor hand hygiene and a lack of effective antiseptics and disinfectants. Specific therapies and methods to prevent and control HuNoV spread previously were difficult to evaluate because of the lack of a cell culture system to propagate infectious virus. This barrier has been overcome with the successful cultivation of HuNoV in nontransformed human intestinal enteroids (HIEs). Here, we report using the HIE cultivation system to evaluate the virucidal efficacy of an …

Analyzing The Effect Of Interview Time And Day On Emergency Medicine Residency Interview Scores, Alanna O'Connell, Sean Greco, Tingting Zhan, Tracy Brader, Megan Crossman, Robin Naples, Anthony Sielicki, Megan Stobart Gallagher, Peter Tomaselli, Dimitrios Papanagnou

Department of Medicine Faculty Papers

Background: When it comes to scheduling interviews, medical students may wonder if they need a strategy to increase their likelihood of matching. Previous studies examined the temporal effects of the residency interview on overall match rate; however, there are additional factors that affect the match process, including board examination scores and letters of recommendation. Only few studies have examined the effect interview time of day has on match success. The current study examines the impact date and time of interview during the interview season have on candidates' respective interview scores.

Methods: Interview data over a three-year period (i.e., three interview …

High Rates Of Undiagnosed And Uncontrolled Hypertension Upon A Screening Campaign In Rural Rwanda: A Cross-Sectional Study, Evariste Ntaganda, Victor G Davila-Roman, Kenneth Schechtman, Angela L Brown, Lisa De Las Fuentes, Dominic Reeds, Et Al.

2020-Current year OA Pubs

BACKGROUND: Hypertension remains the major risk factor for cardiovascular diseases (CVDs) worldwide with a prevalence and mortality in low- and middle-income countries (LMICs) among the highest. The early detection of hypertension risk factors is a crucial pillar for CVD prevention.

DESIGN AND METHOD: This cross-sectional study included 4284 subjects, mean age 46 ± 16SD, 56.4% females and mean BMI 26.6 ± 3.7 SD. Data were collected through a screening campaign in rural area of Kirehe District, Eastern of Rwanda, with the objective to characterize and examine the prevalence of elevated blood pressure (BP) and other CVD risk factors. An adapted …

Barriers And Motivations To Provide Dental Care To Adult Patients With Movement Disorders

Faculty, Staff and Student Publications

Patients with movement disorders, like Parkinson's and Huntington's diseases, tend to have poor oral health. Although contributing factors have been proposed, the willingness and ability of dentists to treat this patient population are still unknown. Our objective is to understand the current barriers and motivations of dentists to treat this patient population as a path to improved care and quality of life. A total of 176 dentists in Texas were surveyed through a structured questionnaire which contained both closed and open-ended questions. Nearly 30% of participants reported having no barriers to treating these patients and 26.7% reported that no such …

Accessory Genomes Drive Independent Spread Of Carbapenem-Resistant Klebsiella Pneumoniae Clonal Groups 258 And 307 In Houston, Tx, Diana Panesso, Hongyu Miao, Carol Hill, Liang Chen, Robin Patel, Bettina C Fries, Lilian Abbo, Eric Cober, Sara Revolinski, Courtney L Luterbach, Henry Chambers, Vance G Fowler, Robert A Bonomo, Samuel A Shelburne, Barry N Kreiswirth, David Van Duin, Blake M Hanson, Cesar A Arias

Faculty, Staff and Student Publications

Carbapenem-resistant Klebsiella pneumoniae (CRKp) is an urgent public health threat. Worldwide dissemination of CRKp has been largely attributed to clonal group (CG) 258. However, recent evidence indicates the global emergence of a CRKp CG307 lineage. Houston, TX, is the first large city in the United States with detected cocirculation of both CRKp CG307 and CG258. We sought to characterize the genomic and clinical factors contributing to the parallel endemic spread of CG258 and CG307. CRKp isolates were collected as part of the prospective, Consortium on Resistance against Carbapenems in Klebsiella and other Enterobacterales 2 …

The Relationships Between And Among Parental Perceptions Of Family-Centered Care, Parental Beliefs, And Parental Stress In The Pediatric Intensive Care Unit, Kelly Keefe-Marcoux

Seton Hall University Dissertations and Theses (ETDs)

Children hospitalized for critical care require increasingly complex and technical care, which can be very stressful for parents. Awareness of the importance of parents’ role while their child is receiving critical care is vital to deliver care within a family-centered philosophy that is mutually beneficial to parents and nurses. This descriptive correlational study examined the relationships between and among parental perception of Family-Centered Care (FCC) nursing practices, parental beliefs regarding their role and their hospitalized child, and parental stress during their child’s admission to the Pediatric Intensive Care Unit (PICU). This study utilized the Family-Centered Care theoretical framework to examine …

Cyclophosphamide Induces Durable Molecular And Clinical Responses In Patients With Relapsed T-Lgl Leukemia., Zachary Braunstein, Eric Mclaughlin, Anjali Mishra, Jonathan E Brammer

Department of Medical Oncology Faculty Papers

No abstract provided.

Problems Of Formation Of Pedagogical Competence Of Physical Education Teachers, Bobur Normamatovich Mengliev

Eurasian Journal of Sport Science

Aim: Coordination of supply and demand for physical education specialists in the labor market, analysis of the "National Qualifications System", which is the basic mechanism for ensuring the competitiveness of teachers in the educational services market.

Methods: make both theoretical and practical conclusions based on the results of a systematic analysis of regulatory documents, scientific and methodological literature and expert assessments.

Results: The main criterion for the formation of pedagogical competence among physical culture specialists is the adoption of such legislative acts as “On measures to organize the activities of the national system of professional skills, knowledge and skills in …

A New Narrative: Freeing Pediatricians From A Single Story, Tanya Scott, Tanya Scott

DNP Qualifying Manuscripts

An adolescent pediatric patient who presents with psychiatric and medical conditions is subject to a pediatrician's diagnostic acuity, experience with pediatric psych patients, and existing constraints on providing an appropriate course of care. Too often, the psychiatric DRG becomes the pediatrician's single story of the patient, accompanied by subtexts of aggressive behavior, and the pediatrician's own biases about psychiatric patients. The novelist Chimamanda Adichie warns of the dangers of a single story. As a child in Nigeria, Adiche devoured stories. The children were fair-skinned and blue-eyed in the books available to her. As Adiche began to write her own stories, …

2022-04-25 Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services

Michigan COVID-19 Hospital Data

Contains the tables Statewide Hospital Capacity Report for COVID-19, COVID-19 Metrics, Statewide Hospital Available PPE Tracking for COVID-19, as well as the tables PPE Days On Hand and Patient Census.

2022-04-25 Michiganoverview_Covidoutbreak, Michigan Department Of Health & Human Services

Michigan COVID-19 Outbreak Reports

The Outbreak Data page was obtained from Michigan's COVID-19 data page: https://www.michigan.gov/coronavirus/stats/outbreak-reporting.

This report is created by the Michigan Department of Health & Human Services from data self-reported by local health departments. Data is updated every week.

COVID-19 outbreaks are generally defined as two or more cases with a link by place and time indicating a shared exposure outside of a household. Local health departments report the number of new and ongoing outbreaks they are investigating by the setting of the outbreak. New outbreaks are those outbreaks that were first identified during the current reporting week. Ongoing outbreaks are …

The Various Nervous System Drugs Commonly Used For Treatment And The Disparities In Availability Of These Drugs In Minority Groups, Iman Haurami

Honors Scholars Collaborative Projects

The nervous system is a complex network in our body that is responsible for actions, reflexes, and even sensations. With the brain being part of the CNS, many common nervous system disorders are due to a defect in the central nervous system and the functions of this organ. These disorders include mental health problems, degenerative diseases, seizures, infections, and other possible genetic diseases. Many of these diseases are common in society and constantly researched. Even though these diseases are common, treatment accessibility and effects on people of minority groups are overlooked compared to the focus on majority groups. For drug …

Covid‑19 Vaccine Distribution: Exploring Strategic Alternatives For The Greater Good, Arben Asllani, Silvana Trimi

Department of Supply Chain Management and Analytics: Faculty Publications

The dire state of the COVID-19 pandemic crisis symbolized the urgency for efficient distribution and administration of vaccines to combat the virus as the most urgent public health service. This paper presents a prototype multi-criteria decision support model based on goal programming that can effectively support vaccination plans for the greater good of society. The optimization goals of the model include minimizing the number of fatalities and risk of spreading the disease, while complying with government health agency’s priority guidelines for vaccination. This study applied the model to a real-world dataset to demonstrate how it can be effectively applied as …

Dating App Facilitated Sexual Assault: A Growing Phenomenon, Kristen Mella Hamblin

Theses and Dissertations

Dating App Facilitated Sexual Assault (DAppSA) is a new phenomenon and growing concern. Research on DAppSA is extremely limited. This study aimed to identify unique victim and assault characteristics associated with DAppSAs. A retrospective SAMFE chart review of patients (N = 3,413) from 2017 to 2020 was conducted. Sexual assault nurse examiners completed SAMFEs. Inclusion criteria for DAppSA cases included 1) victim was 14 years of age or older; 2) victim indicated they met the perpetrator on a dating website or app; 3) the SA occurred at the initial in-person meeting; 4) victim had a SAMFE with evidence collection. DAppSAs …

Développement D’Une Méthodologie Pour Évaluer La Performance Des Gants À Isoler Des Vibrations En Tenant Compte De La Dextérité Ainsi Que De La Force De Préhension, Pierre Marcotte, Subhash Rakheja, Christian Larivière, Yumeng Yao, Chantal Gauvin, Karim Hamouda, Hakim Mecheri

Rapports de recherche scientifique

L'efficacité des gants antivibrations pour réduire les vibrations transmises à la main est actuellement évaluée en laboratoire selon la méthodologie décrite dans la norme ISO 10819:2013. Cette norme évalue la transmission des vibrations à la paume de la main, mais ne tient pas compte de la transmission des vibrations aux doigts ni de l’effet du port de ces gants sur la dextérité manuelle et l’effort de préhension. Cette étude visait à développer une méthodologie afin d’améliorer l’évaluation de la transmission des vibrations par les gants antivibrations à la paume et aux doigts, tout en tenant compte de l’effet de ces …

The Texas Community-Engagement Research Alliance Against Covid-19 In Disproportionately Affected Communities (Tx Ceal) Consortium, Rebecca A. Seguin-Fowler, Chris Amos, Bettina M. Beech, Robert L. Ferrer, Lorna Mcneill, Jasmine J. Opusunju, Emily Spence, Erika L. Thompson, Luis R. Torres-Hostos, Jamboor K. Vishwanatha

School of Social Work Faculty Publications

The coronavirus disease 2019 (COVID-19) pandemic requires urgent implementation of effective community-engaged strategies to enhance education, awareness, and inclusion of underserved communities in prevention, mitigation, and treatment efforts. The Texas Community-Engagement Alliance Consortium was established with support from the United States’ National Institutes of Health (NIH) to conduct community-engaged projects in selected geographic locations with a high proportion of medically underserved minority groups with a disproportionate burden of COVID-19 disease and hospitalizations. The purpose of this paper is to describe the development of the Consortium. The Consortium organized seven projects with focused activities to address COVID-19 clinical and vaccine trials …

Implementation Of A Decision Tree To Address Moral Distress, Tijuana Milton

Doctor of Nursing Practice (DNP) Translational and Clinical Research Projects

Healthcare workers (HCW) face daily challenges in the workplace environment. A relatively new problem called moral distress (MD) may present itself, but it may go unrecognized. The healthcare profession is being robbed of qualified personnel due to moral distress. The overall objective of this project was to help healthcare workers identify moral distress and seek resources to assist with the mitigation of moral distress. The outcome of this project demonstrated bedside HCWs showed higher levels of MD. Leadership must be intentional with providing education about the signs and symptoms of MD and assist employees to recognize and utilize available resources …

Parental Sleep When Their Child Is Sick: A Phased Principle-Based Concept Analysis, Stephanie Smith, Mary Tallon, James Smith, Charlotte Angelhoff, Evalotte Mörelius

Research outputs 2022 to 2026

Sleep is a common challenge for parents with sick children and can impact parents' health, wellbeing, and caregiving responsibilities. Despite the vast research around parental sleep when their child is sick, the concept is not clearly defined. A phased principle-based concept analysis that includes triangulation of methods and quality criteria assessment was used to explore how the concept is described, used, and measured in the current literature. The aim was to analyse and clarify the conceptual, operational, and theoretical basis of parental sleep when their child is sick to produce an evidence-based definition and to identify knowledge gaps. A systematic …

Medical Cannabis: Alternative To Opioids For The Treatment Of Chronic Pain, Brenda F. Seaton

MSN Capstone Projects

There is a growing body of evidence to suggest that cannabinoids (CBD) are beneficial for a range of clinical conditions, including chronic pain, sleep disorders, osteoarthritis inflammation, anxiety, depression, and enhanced quality of life. For patients with chronic pain and arthritis inflammation, traditionally pain-relieving medications, including opioids, have been prescribed for pain relief but with increased risks of addiction and adverse effects with poor outcomes. Medical cannabis use is an emerging treatment alternative to prescription opioids and as an adjunctive to diminish the use of opioids addiction. This project objectively reviews the works of literature on the challenges of proposing …

Acquire’Ingscholarly Activity During Residency: An Analysis Of Resident Attitudes Towards Scholarship Before And After A Curricular Intervention, Thomas Q Reynolds, Sarah Gabrielson, Amy Buczkowski, Anya K. Cutler, Gina Trachimowicz

Costas T. Lambrew Research Retreat 2022

ACQUIRE, a curriculum designed to introduce residents to scholarship and support their work, results in improvement in resident perceptions towards scholarly activity at both individual and department levels.

Cytokine Cxcl2 Concentration In The Cerebrospinal Fluid Of Patients With Aneurysmal Subarachnoid Hemorrhage Is Associated With Patient-Reported Headache Pain, Elizabeth Glisic, Joanne T. Dekay, Patricia Lerwick, David J. Gagnon, Richard Riker, Sergey Ryzhov

Costas T. Lambrew Research Retreat 2022

Subarachnoid hemorrhage (SAH) is a severe type of stroke categorized by a sharp, sudden, and persistent headache. The mechanism of headache after SAH is currently poorly understood but the neuro-inflammatory response has been identified as a target in understanding the causes of headache after SAH. A better understanding of this mechanism may lead to identification of molecular targets for therapeutic reduction of headache pain and improving outcomes after SAH. In this study, we collected cerebrospinal fluid (CSF) from patients hospitalized with SAH and conducted a cytokine array to screen for soluble factors involved in SAH-associated headache Introduction