Medicine and Health Sciences Commons^™

The Responsiveness Of Muscle Strength Tests In Adults With Intellectual Disabilities, S. Weterings, A. Oppewal, S. M.A. Bierma-Zeinstra, T. I.M. Hilgenkamp

Physical Therapy Faculty Research

Background Muscle strength is both a strong predictor for future negative health outcomes and a prerequisite for physical fitness and daily functioning of adults with ID. Therefore, it is important to be able to monitor the muscle strength of adults with ID over time. The aim of this study is to assess the responsiveness of five field tests that measure muscle strength and endurance (grip strength, hand-held dynamometry of leg extension and arm flexion, 10RM-test of the seated squat and the biceps curl, 30-s chair stand and the 5-times Chair stand) in adults with ID after a 24-week resistance-exercise training …

Analysis Of Firearm Violence During The Covid-19 Pandemic In The Us, Shengzhi Sun, Wangnan Cao, Yang Ge

Faculty Publications

Importance In the US, the COVID-19 pandemic intensified some conditions that may contribute to firearm violence, and a recent surge in firearm sales during the pandemic has been reported. However, patterns of change in firearm violence in the first year of the COVID-19 pandemic in the US remain unclear.

Objective To quantify the changes in interpersonal firearm violence associated with the pandemic across all 50 US states and the District of Columbia.

Design, Setting, and Participants This population-based cross-sectional study examined 50 US states and the District of Columbia from January 1, 2016, to February 28, 2021. The COVID-19 pandemic …

Parenthood Orientation Among Young Women: Is It Associated With Pregnancy Intention And Unprotected Intercourse?, Nakeisha Blades

Theses and Dissertations

This study explored relationships between parenthood orientation, pregnancy intention, and unprotected intercourse. Nulligravid, sexually active women aged 18-29 (N = 252) were surveyed on these topics in May 2019. There were significant differences in parenthood orientation by past and current pregnancy intention. Higher scores on parenthood orientation were associated with increased odds of past unprotected intercourse and expecting future unprotected intercourse. Only education and contraceptive self-efficacy retained significance in adjusted models. Study results are consistent with prior work on parenthood orientation and pregnancy intention and point to other factors as stronger correlates of contraceptive use.

A Therapeutic Sheep In Metastatic Wolf's Clothing: Trojan Horse Approach For Cancer Brain Metastases Treatment, Hai-Jun Liu, Mingming Wang, Shanshan Shi, Xiangxiang Hu, Peisheng Xu

Faculty Publications

Early-stage brain metastasis of breast cancer (BMBC), due to the existence of an intact blood–brain barrier (BBB), is one of the deadliest neurologic complications. To improve the efficacy of chemotherapy for BMBC, a Trojan horse strategy-based nanocarrier has been developed by integrating the cell membrane of a brain-homing cancer cell and a polymeric drug depot. With the camouflage of a MDA-MB-231/Br cell membrane, doxorubicin-loaded poly (D, L-lactic-co-glycolic acid) nanoparticle (DOX-PLGA@CM) shows enhanced cellular uptake and boosted killing potency for MDA-MB-231/Br cells. Furthermore, DOX-PLGA@CM is equipped with naturally selected molecules for BBB penetration, as evidenced by its boosted capacity in entering …

The Role Of Socio-Cultural Perspectives And Vaccine Misinformation On The Intention To Receive Covid-19 Vaccination In A Selected Sample Of Georgia Southern Students, Alyssa G. Love-Archey

Honors College Theses

The purpose of the study was to explore sociocultural influences on the intention to receive the Covid-19 vaccination and to measure which sociocultural factor had the greater influence: misinformation about the vaccine or specific cultural beliefs (religion and/or cultural practices) on vaccine intent in Georgia Southern students. An anonymous, exploratory survey was utilized to collect information on these constructs in two selected groups of students: those who had been vaccinated prior to taking the survey and those who had not been vaccinated prior to taking the survey. Subjects of the study were undergraduate, master’s degree, and doctoral students of the …

Vaccine Protection Against The Sars-Cov-2 Omicron Variant In Macaques, Abishek Chandrashekar, Adrianus C. M. Boon, Et Al.

2020-Current year OA Pubs

The rapid spread of the SARS-CoV-2 Omicron (B.1.1.529) variant, including in highly vaccinated populations, has raised important questions about the efficacy of current vaccines. In this study, we show that the mRNA-based BNT162b2 vaccine and the adenovirus-vector-based Ad26.COV2.S vaccine provide robust protection against high-dose challenge with the SARS-CoV-2 Omicron variant in cynomolgus macaques. We vaccinated 30 macaques with homologous and heterologous prime-boost regimens with BNT162b2 and Ad26.COV2.S. Following Omicron challenge, vaccinated macaques demonstrated rapid control of virus in bronchoalveolar lavage, and most vaccinated animals also controlled virus in nasal swabs. However, 4 vaccinated animals that had moderate Omicron-neutralizing antibody titers …

Improving Provider Adherence To Ada Clinical Practice Guidelines: A Qi Project In A Patient Centered Medical Home, David H. Kamp

Masters Projects

Background and purpose: Diabetes is the leading cause of kidney failure, lower limb amputations, and adult blindness. The American Diabetes Association recommends timely screenings to reduce complications. Flowsheets facilitate improved outcomes. The project implemented an electronic flowsheet to promote staff adherence to select screenings.

Methods: Screenings included foot exam, eye exam, glycohemoglobin, microalbumin creatinine ratio, lipid profile, and anti-hypertensive medication. Staff viewed the flowsheet to determine screening eligibility per ADA guidelines. Quantitative and qualitative data analyzed.

Results: Quantitative results: 40% improvement among medical assistants (MAs) completing foot exams and 75.53% improvement among providers ordering eye exams. No statistical significance among …

Improving Vaccination Rates In Pediatric Primary Care, Lauren E. Osbeck

Doctoral Dissertations & Projects

Objectives: In a small, rural pediatric primary care clinic, the effectiveness of electronic patient portal reminders were evaluated at improving vaccination rates for school required immunizations.

Methods: A quality improvement project was initiated utilizing The Social Ecological Model. All pediatric patients were sent reminders who were under-immunized. This QI project evaluated the effectiveness of vaccine reminders on the improvement of immunization rates in the clinic

Results: Total number of fully-vaccinated patients within the practice improved (2%) and patients under-immunized decreased by 1%. 87 immunizations were given to patients were given to patients who were under-immunized and an average of 10% …

Children Of Divorce Parents Group Manual, Sheyenne Hokit

Dissertations, Theses, and Projects

Divorce is something that is, unfortunately, becoming a commonality for a lot of children, and due to the complexity of divorce, many children struggle when trying to understand divorce and how it affects them. Some effects of divorce are various emotional and behavioral issues such as increased anger and decreased emotion regulation. Social, health, and academic concerns were also found. Counseling interventions like narrative therapy, emotion-focused family therapy, emotion-focused therapy, and play therapy were found to be effective with this population (Hirschfeld & Wittenborn, 2016, Thomas & Gibbons, 2009). The identified interventions provide peer-based social support, education on the misconceptions …

Increasing Physical Activity In Women With Obesity To Promote Weight Loss, Ashley N. Kohler

Evidence-Based Practice Project Reports

Obesity is a chronic disease associated with a multitude of lifelong chronic illnesses. Obesity impacts more than 42% of the United States population (CDC, 2021b). Physical inactivity is a major determinant of obesity (Muerer et al., 2019). The purpose of this evidence-based practice (EBP) project was to promote a greater reduction in body mass index (BMI) of the participants enrolled in an existing wellness program at the EBP practice site by increasing the physical activity level of the participants compared to standard protocol. The existing wellness program’s standard protocol included diet modifications, physical activity encouragement, and medication management. The EBP …

The Rey Auditory Verbal Learning Test: Cross-Validation Of Mayo Normative Studies (Mns) Demographically Corrected Norms With Confidence Interval Estimates, David W. Loring, Jessica L. Saurman, Samantha E. John, Stephen C. Bowden, James J. Lah, Felicia C. Goldstein

Brain Health Faculty Research

Objective: The Mayo Normative Studies (MNS) represents a robust dataset that provides demographically corrected norms for the Rey Auditory Verbal Learning Test. We report MNS application to an independent cohort to evaluate whether MNS norms accurately adjust for age, sex, and education differences in subjects from a different geographic region of the country. As secondary goals, we examined item-level patterns, recognition benefit compared to delayed free recall, and derived Auditory Verbal Learning Test (AVLT) confidence intervals (CIs) to facilitate clinical performance characterization. Method: Participants from the Emory Healthy Brain Study (463 women, 200 men) who were administered the AVL were …

Electroconvulsive Therapy Safety Biomarkers, Jeremy Duvall Miller

Biomedical Sciences ETDs

Objective: The two studies presented utilize neuroimaging data to evaluate potential therapeutic and safety biomarkers in depressed patients receiving Electroconvulsive Therapy (ECT).

Method: The first study enrolled 41 depressed subjects receiving ECT from two independent sites and evaluated gamma aminobutyric acid (GABA+) in the anterior cingulate cortex with proton-spectroscopy contrasted with healthy controls and therapeutic and cognitive outcomes. The second study investigated 17 subjects receiving ECT and evaluated ictal theta power during ECT to electric dose measured by E-field modeling, therapeutic and cognitive outcomes.

Results: No significant difference was seen in GABA+ in depressed subjects receiving ECT compared to healthy …

Patient Knowledge Of Family History Of Cardiac Events And Risk Factors: Potential For Increase In Preventative Care Of Cardiovascular Diseases, Joseph Marentette

Honors Theses

The following literature review regards the preventative care of cardiovascular disease (CVD) patients with the knowledge of familial cardiac events and personal cardiac risk factors, particularly in younger populations ranging from ages 18 to 39, and develop potential preventative care measures. CVD is preventable with early reduction of risk factors. People can lower the impact of cardiac risk factors through the modification of their current lifestyle and behavioral habits. However, this is limited to the education and motivation of the person. Primary emphasis must be placed on community education and physician-patient interactions regarding CVD and cardiac risk factors. Physicians need …

Exploring The Millennial Novice Nurses' Transition Experience In Hospital Setting: An Integrative Review, Carman Dean

Master of Science in Nursing Final Projects

The nursing shortage coupled with a high demand for healthcare services necessitates retention of the current workforce comprised of a majority of millennial generation nurses. This generational cohort has previously demonstrated a lower job commitment and job satisfaction as compared to prior generations as well as individual work preferences. The purpose of this integrative review was to evaluate and synthesize previous studies that capture the millennial novice nurse’s experience in the hospital setting and to answer the question, “What are the initial transition experiences of millennial generation novice nurses in the hospital setting?” An integrative review design was used to …

The Effect Of Social Media On Providence College Students, Kathryn Ernst, Margaret Grasberger, Allie Mcguire, Mairead Ryan

School of Business Student Scholarship

Kathryn Ernst ’24, Major: Marketing

Margaret Grasberger ’24, Major: Marketing

Allie McGuire ’24, Major: Marketing

Mairead Ryan ’24, Major: Marketing

Faculty Mentor: Dr. Kevin Newman, Marketing

Recent research indicates that social media usage is addictive both physically and psychologically. Due to the prevalence of social media, our group specifically wanted to study how its usage impacted Providence College students’ mental health, physical health, and communication skills (both in-person and online communication skills). We found that social media usage negatively affects students’ mental and physical health, with females being more impacted than males. However, we did not find evidence to support …

Ameliorative Effects Of Minor Cannabinoids Over Hiv-1 Tat-Mediated Visceral Pain, Charlie Worth

Honors Theses

As the total number of people living with HIV continues to rise across the world, an effective HIV treatment is still sought after. While modern-day advanced therapies exist for mitigating much of the negative effects of HIV, the virus remains evasive and problematic in the central nervous system. Thus, even with treatment, many people living with HIV continue to suffer from a plethora of symptoms. However, a large proportion of HIV-positive patients claim to feel a reduction in those persevering symptoms after cannabis usage. This anecdotal evidence has sparked interest in the efficacy of cannabis constituents for HIV therapy. This …

Using A Food Insecurity Screening Tool In The Nicu, Emily Coffman Bsn, Rn, Fatina Caldwell Bs, Bsn, Rn, Cpn, Cpen, Mackenzie Box Bsn, Rn, Uche Anani Md, Faap, Christin Fritz Md, Mph, Bobby Bellflower Dnsc, Nnp-Bc, Faanp

Doctor of Nursing Practice Projects

Purpose/Background: Infants admitted to the NICU are disproportionately born to low-income families. This, combined with unique financial challenges of their long-term stay, may predispose caregivers to food insecurity (FI). FI among caregivers has far reaching implications for the health of infants who are already vulnerable related to comorbidities from their NICU stay.

Methods: Using the Iowa model to successfully engage key stake holders and begin a small pilot study, a randomized preintervention chart audit was performed (n=30) to evaluate if FI was identified by NICU Social Worker (SW). The FI screening tool was administered by nursing to a separate group …

Long-Acting Antipsychotic Injectables Vs. Oral Antipsychotics: Comparing Compliance, Relapse, And Re-Hospitalization Rates, Latoria Boyland Bsn, Rn, Kara Darretta Bsn, Rn, Ansley Geno Bsn, Rn, Keevia Porter Dnp, Np-C, Rn

Doctor of Nursing Practice Projects

Purpose/Background Psychosis is a psychiatric disorder characterized by hallucinations and delusions. These symptoms not only negatively impact a patient’s quality of life but can also make treatment compliance difficult. This lack of treatment compliance ultimately leads to higher relapse and re-hospitalization rates among this population. Thus, it is imperative that effective treatments are developed, utilized, and made readily available for patients. Antipsychotics are medications that block dopamine D2 receptors. These medications are used for psychosis to help to improve patient outcomes. Currently, two routes of antipsychotic administration are available, oral antipsychotics or long-acting antipsychotic injections (LAIs). Oral antipsychotic administration requires …

College Students’ Psychological Well-Being During The Covid-19 Pandemic: An Investigation Based On Students’ Gender And Education Level, Muh. Farozin, Diana Septi Purnama, Budi Astuti, Arif Budi Prasetya, Anifa Tuzzuhroh Nurbaiti

Jurnal Kajian Bimbingan dan Konseling

This study aims to determine the level of psychological well-being based on gender and level of education being pursued during the Covid-19 pandemic. Participants are students from various faculties and postgraduate programs from diploma, undergraduate, professional education, masters and doctoral education levels in Yogyakarta, Indonesia. The instrument used is the Ryff Psychological Well-Being Scale which has been adapted by Engger with a content validity value of CVR equal to 1 which is in the good category and reliability is 0.935 in the good category. The data analysis used was Mann-Whitney non-parametric statistics for the different test of psychological well-being based …

Single Session Counseling Integrated With Expressive Art To Improve Students' Internet Altruistic Behavior, Ganjar Suargani, Mulawarman Mulawarman, Awalya Awalya

Jurnal Kajian Bimbingan dan Konseling

The internet is one of the means to obtain information, interact, and even provide help to others. To be able to give voluntary help based on empathy, one must have internet altruistic abilities. This study aims to determine the effectiveness of single-session counseling with expressive art integration to improve students’ altruistic behavior on the internet. This study used a randomized pretest-posttest control group design. The intervention in the experimental group used a single session counseling strategy that was integrated with expressive art. The control group was given an intervention in the form of individual counseling without using a single session …

Perceived Roles, Benefits And Barriers Of Virtual Global Health Partnership Initiatives: A Cross-Sectional Exploratory Study, Grace Abongo, Jessica Evert, Heather Haq, Elizabeth M Keating, Suet Kam Lam, Megan S Mchenry, Carolyne Ndila, Charles Nwobu, Amy Rule, Reena P Tam, Daniel Olson, Peter Olupot-Olupot

Faculty, Staff and Students Publications

BACKGROUND: Virtual global health partnership initiatives (VGHPIs) evolved rapidly during the COVID-19 pandemic to ensure partnership continuity. However the current landscape for VGHPI use and preference is unknown. This study aimed to increase understanding of GH partners' perspectives on VGHPIs.

METHODS: From 15 October to 30 November 2020, An online, international survey was conducted using snowball sampling to document pandemic-related changes in partnership activities, preferences for VGHPIs, and perceived acceptability and barriers. The survey underwent iterative development within a diverse author group, representing academic and clinical institutions, and the non-profit sector. Participants from their professional global health networks were invited, …

Enpp1 Variants In Patients With Gaci And Pxe Expand The Clinical And Genetic Heterogeneity Of Heritable Disorders Of Ectopic Calcification., Douglas Ralph, Yvonne Nitschke, Michael A Levine, Matthew Caffet, Tamara Wurst, Amir Hossein Saeidian, Leila Youssefian, Hassan Vahidnezhad, Sharon F Terry, Frank Rutsch, Jouni Uitto, Qiaoli Li

Department of Medicine Faculty Papers

Pseudoxanthoma elasticum (PXE) and generalized arterial calcification of infancy (GACI) are clinically distinct genetic entities of ectopic calcification associated with differentially reduced circulating levels of inorganic pyrophosphate (PPi), a potent endogenous inhibitor of calcification. Variants in ENPP1, the gene mutated in GACI, have not been associated with classic PXE. Here we report the clinical, laboratory, and molecular evaluations of ten GACI and two PXE patients from five and two unrelated families registered in GACI Global and PXE International databases, respectively. All patients were found to carry biallelic variants in ENPP1. Among ten ENPP1 variants, one homozygous variant demonstrated uniparental disomy …

India's Ban On Antimicrobial Fixed-Dose Combinations: Winning The Battle, Losing The War?, Giorgia Sulis, Richeek Pradhan, Anita Kotwani, Sumanth Gandra

2020-Current year OA Pubs

BACKGROUND AND OBJECTIVES: India, the country with the largest market availability of antimicrobial fixed-dose combinations (FDCs), banned certain antimicrobial FDCs in September 2018. Our objective was to examine the impact of Government ban on the sales of antimicrobial FDCs.

METHODS: The sales patterns of 14 of the 26 banned antimicrobial FDCs were analyzed using monthly private sector drug sales data from IQVIA (a comprehensive and nationally representative drug sales database) between January 2018 and December 2019. We carried out descriptive analyses to evaluate the trend in sales over time for banned and non-banned antimicrobial FDCs using cumulative sales volumes.

RESULTS: …

Thermodynamically Coupled Biosensors For Detecting Neutralizing Antibodies Against Sars-Cov-2 Variants, Jason Z Zhang, Laura A Vanblargan, Michael S Diamond, Et Al.

2020-Current year OA Pubs

We designed a protein biosensor that uses thermodynamic coupling for sensitive and rapid detection of neutralizing antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants in serum. The biosensor is a switchable, caged luciferase-receptor-binding domain (RBD) construct that detects serum-antibody interference with the binding of virus RBD to angiotensin-converting enzyme 2 (ACE-2) as a proxy for neutralization. Our coupling approach does not require target modification and can better distinguish sample-to-sample differences in analyte binding affinity and abundance than traditional competition-based assays.

Benefits Of, Barriers To, And Needs For An Artificial Intelligence-Powered Medication Information Voice Chatbot For Older Adults: Interview Study With Geriatrics Experts, Padmavathy Ramaswamy, Kirk Roberts

Faculty, Staff and Student Publications

BACKGROUND: One of the most complicated medical needs of older adults is managing their complex medication regimens. However, the use of technology to aid older adults in this endeavor is impeded by the fact that their technological capabilities are lower than those of much of the rest of the population. What is needed to help manage medications is a technology that seamlessly integrates within their comfort levels, such as artificial intelligence agents.

OBJECTIVE: This study aimed to assess the benefits, barriers, and information needs that can be provided by an artificial intelligence-powered medication information voice chatbot for older adults.

METHODS: …

Development Of Instrumen Eksplorasi Karier Anne Roe (Iekar) For Junior High School Students, Dhanang Suwidagdho, Edi Purwanta

Jurnal Kajian Bimbingan dan Konseling

This study aims to develop a career exploration instrument based on Anne Roe’s classification to help junior high school students explore their career options. The development method uses the Syaiffudin Azwar instrument development model with 8 stages, namely the identification of measuring objectives; measuring domain restrictions; operationalization of aspects; writing and reviewing items; language test; field tests; item selection and; final compilation. The field test was carried out on 306 junior high school students in the Godean area, Yogyakarta. The results of the CFA test show that all instrument items that make up the 8 career groups obtained fit results …

Impact Of Cyber Relational Addiction On Undergraduates’ Interpersonal Relationship In Nigeria, Mulikat Ladi Abdulqadir Mustapha, Michael Ajokpaniovo, Faith Elizabeth Olaoye

Jurnal Kajian Bimbingan dan Konseling

The upsurge in the use of cyberspace in recent years has led to pathological use for some individuals especially in the area of cyber relational addiction. This study aimed to investigate the influence of cyber relational addiction on interpersonal relationships and how variables of age, religion, levels of study, and gender of respondents moderate the influence of cyber relational addiction on their interpersonal relationships. This study employed a descriptive survey research design and administered a self-designed questionnaire on 420 randomly selected undergraduates from seven faculties at the University of Ilorin. A research question was answered in this study, while the …

Smartphone Addiction Among Adolescence Students: Its Implication Toward Family Communication, Learning, Guidance And Counselling, Adi Atmoko, Indah Kartika Sari, Augusto Da Costa, Nugraheni Warih Utami, Eny Tri Wahyuni

Jurnal Kajian Bimbingan dan Konseling

The symptoms of smartphone addiction have been extensively observed in adolescent students. This study aims to investigate the effects of smartphone addiction on students’ communication with their families, their learning, as well as guidance and counseling processes. The causal correlational design was applied, involving 103 participants selected total samplings of eighth-graders junior high school students. The data was garnered through the smartphone addiction scale and family communication scale. Both of those scales had item validity of 0.3, with Alpha Cronbach reliability of 0.937 and 0.850, respectively. The obtained data were analyzed using regression. The analysis results suggest that smartphone addiction …

Author Correction: Short Amylin Receptor Antagonist Peptides Improve Memory Deficits In Alzheimer’S Disease Mouse Model, Rania Soudy, Ryoichi Kimura, Aarti Patel, Wen Fu, Kamaljit Kaur, David Westaway, Jing Yang, Jack Jhamandas

Pharmacy Faculty Articles and Research

Correction to: Scientific Reports https://doi.org/10.1038/s41598-019-47255-9, published online 29 July 2019

The original Article contained an error in Figure 1A where the control trace for both the HEK-AMY3 and HEKWT cells was duplicated...

The original Article has been corrected.

The Effects Of A Formal Organizational Program On Nursing Supervisor Self-Perception Of Leadership, Jonathan Allen Judy-Del Rosario

Doctor of Nursing Practice Scholarly Projects

Nursing house supervisors oversee hospital operations during evenings, nights, weekends, and holidays, yet many feel disconnected from others in the nursing leadership team. These individuals work as the sole leader on duty, having limited interaction with the daytime leaders and often lack formal leadership development. This quantitative, quasi-experimental study explored the effects of implementing a formal educational and team building program on the perception of the supervisor’s leadership skills as well as collaboration with the leadership team. The Leadership Practices Inventory and the Collaborative Behavior Scale – Shortened were the two surveys administered to assess the effects of this program. …