Medicine and Health Sciences Commons^™

Variation In Thiopurine Metabolism In Hispanic Children, Kayeleigh Higgerson Do

Research Days

Background: Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. Overall survival rate is > 90% in the United States. However, ethnic and racial disparities remain. Hispanic patients have an inferior overall survival compared to non-Hispanics. The reasons for these differences remain unclear. Mercaptopurine (6MP) is a crucial drug in ALL treatment. Variations in the TMPT and NUDT15 genes lead to altered 6MP metabolism and accumulation of toxic metabolites (6TGN or 6MMPN). Each metabolite is associated with specific dose-limiting toxicities. The accumulation of 6TGN causes myelosuppression, and increased 6MMPN causes GI toxicity. While variants in these genes have been identified …

Potassium Status In Pediatric Chronic Kidney Disease, Katherine L. Kurzinski

Research Days

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Background: Potassium trends are well described in adult chronic kidney disease (CKD) and hyperkalemia is known to be associated with increased disease progression, morbidity, and mortality. Large scale studies assessing potassium trends and the prevalence of hyperkalemia in pediatric CKD have not been performed.

Objectives/Goal: We aimed to characterize median serum potassium levels and the prevalence of hyperkalemia for each CKD stage using the CKiD cohort. The relationship of serum potassium and hyperkalemia with patient demographics, CKD etiology (glomerular or non-glomerular), presence of acidosis, and degree of proteinuria was also evaluated.

Methods/Design: Median serum potassium …

Association Of Rare Variants In Kidney Developmental Genes With Hypertension And Ckd: A Uk Biobank Study, Benjamin L. Spector

Research Days

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Background: Prior studies show chronic kidney disease (CKD) is heritable but only a few common variants have been associated with CKD and kidney dysfunction. Much of CKD heritability remains unknown and limited studies have explored the role of rare genetic variants in this missing heritability.

Objectives/Goal: Identify rare genetic variants in renal developmental genes associated with hypertension and CKD.

Methods/Design: We examined the association between rare variants in 58 candidate genes from five renal developmental compartments and presence of CKD and elevated blood pressure (BP) in 49,989 individuals using whole exome sequencing and phenotypic data …

Type 2 Diabetes Mellitus During The Covid-19 Pandemic, Erica Wee

Research Days

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Background The prevalence of type 2 diabetes mellitus (T2D) in youth has increased significantly over the past decades secondary to the increased prevalence of obesity. Epidemiologic data estimates that the incidence of youth-onset T2D increased 5% per year between 2002 and 2012. Recent studies have shown that childhood obesity increased with the COVID-19 pandemic. However, if this resulted in increased incidence of T2D has not been well-reported.

Objectives: This study seeks to evaluate new-onset T2D in youth during the COVID-19 pandemic (March 2020 to February 2021). We examined the frequency of new-onset T2D and proportion …

The Understanding Of Mycorrhizae Networks: A Historical Approach, Jake Sun

The Confluence

The growth of mycorrhizal fungi into plant roots used to be viewed as a parasitic relationship between plants and fungi, where the fungal symbiont benefits and the plant host is harmed. Current research elucidates a mutualistic relationship. The mycorrhizae network assists the plants by increasing the capabilities for nutrient absorption in the soil. In exchange, the fungi receive carbon supply from the photosynthetic plants for growth. Our scientific understanding of other topics like species specificity, seed germination, and co-evolutionary influence of mycorrhizae and plants has also progressed. Additionally, we now understand that the mycorrhizal mutualism is not limited to the …

Treatment Of Recurrent Wilms Tumor With Irinotecan/Temozolomide, Meagan Vacek

Research Days

Background: Despite improvement in relapse free survival (RFS) in recurrent Wilms tumor, the 4- year RFS rate for patients treated with vincristine/dactinomycin/doxorubicin is approximately 40%. Ifosfamide, carboplatin and etoposide are commonly used in relapsed solid tumors but have significant toxicities and require hospital admission for administration. Our patient focused on quality of life, and this led to exploration of other treatment options.

Objectives/Goal: Describe a case of multiply relapsed Wilms tumor with management on oral chemotherapy for improved quality of life and remission for almost 1 year.

Methods/Design: Case Report

Results: The patient is an 11-year-old female diagnosed with Wilms …

Increasing Incentive Spirometry Use In Patients With Sickle Cell Disease Admitted To Children’S Mercy Hospital, Thomas Cochran, Alexandra Prosser

Research Days

Background: Acute chest syndrome is one of the leading causes of morbidity and mortality in patients with sickle cell disease. The National Heart, Lung, and Blood Institute (NHLBI) provides specific recommendations for providing ten breaths of incentive spirometry (IS) every two hours while awake for patients with sickle cell disease to help prevent development of acute chest syndrome.

Problem Statement: We reviewed provision of incentive spirometry at Children’s Mercy between 08/01/2021 and 11/01/2021. Data was collected and the target population was identified via a report generated from the electronic medical records with specific criteria. Of those patients admitted with sickle …

Wilms Tumor Presenting With Spontaneous Necrosis And Clostridium Perfringens Co-Infection, Ronald Palmen, Abbey Elsbernd, Kristin Palmen

Research Days

Background: Wilm’s Tumor (WT) is the most common renal malignancy of childhood. The initial presentation of WT may mimic infection or other malignancies with nonspecific symptoms including fever, abdominal/flank pain, or hematuria. This poses a diagnostic challenge for providers, particularly when both infection and malignancy are observed. We describe a case of WT with spontaneous necrosis initially obscured by overlying Clostridium perfringens infection, making diagnosis of the cancer difficult.

Case Description: A previously healthy 5-year-old girl presented to the emergency department with a two-day history of left flank pain and fevers. In the emergency department, she was tachycardic (130 bpm), …

Acute Complications In Pediatric Patients With Diabetes Admitted With Isolated Diabetic Ketoacidosis, Isolated Hyperglycemic Hyperosmolar State, And Mixed Hyperosmolar Diabetic Ketoacidosis, Erica Zarse

Research Days

Background: Diabetic ketoacidosis (DKA), hyperglycemic hyperosmolar state (HHS), and mixed DKA and HHS (hyperosmolar DKA) are hyperglycemic emergencies for which children with diabetes mellitus (DM) are admitted to the hospital. To date, there is little evidence to guide the management of pediatric diabetic patients with hyperosmolarity.

Objectives: The objective of this study is to compare the in-hospital complications at our institution in patients who have isolated DKA to those with a component of hyperosmolarity.

Methods: We reviewed medical records of patients from 01/2019 through 12/2020 admitted with DKA (serum bicarbonate ≤16 mEq/L) and/or HHS (blood glucose ≥600 mg/dL and osmolality …

Case Series: Bone Marrow Failure In Teen Siblings With Unique Rps19 Variant, Alexandra Prosser

Research Days

Background: Upon diagnosis of aplastic anemia, inherited bone marrow failure syndromes and acquired etiologies must be considered. Investigating causality is particularly important when multiple family members are affected. It is also essential to identify novel causative genetic variants of bone marrow failure to direct treatment in these patients.

Objectives: To describe the diagnosis and management of siblings who presented two weeks apart with severe pancytopenia and were diagnosed with severe aplastic anemia.

Methods: The first patient is a 13-year-old non-binary female who presented with severe pancytopenia on routine labs. Bone marrow biopsy revealed marked hypocellularity (0-10%) with hypoplasia. The second …

Memory T Cell Populations In Human Leukemia, Sara Mcelroy

Research Days

Background: Incorporating the immune system into cancer management is an area of robust research. Treatment modalities aimed at activating cytotoxic T cells against malignancies include immune checkpoint inhibitors, bispecific T-cell engagers, and chimeric antigen receptor (CAR) tumor-specific T cells. Most anti-cancer T cell research is narrowly focused, but knowledge about the nature of diverse sub-populations of T cells in cancer, particularly memory T cells, is vital prior to potential incorporation into therapies. T memory stem cells (Tscm) are of interest due to their longevity and powerful abilities of self-renewal and creating the full spectrum of memory CD8+ T cells, including …

Quality Improvement Project To Improve Provider-To-Nursing Communication During Daily Rounds, Kayeleigh Higgerson Do, Sara Mcelroy Md

Research Days

Problem Statement/Question: We aim that by June 2021, our Heme/Onc resident service daily table rounds will include 80% of bedside nurses to improve communication between the provider team and bedside nurse.

Background/Project Intent (Aim Statement): Daily rounds on our Heme/Onc resident service include table rounds (discussion of overnight events and daily plan) and bedside rounds (team goes to see patients and relay daily plan). These rounds infrequently include the bedside nurse caring for the patient, leading to poor communication of the plan from the provider team. This is a problem, because it has the potential to lead to medical errors …

Acute Kidney Injury In Youth With Diabetes Admitted With Isolated Diabetic Ketoacidosis, Isolated Hyperglycemic Hyperosmolar State, And Hyperosmolar Diabetic Ketoacidosis: A Single Center Experience, Erica Zarse

Research Days

Background: Diabetic ketoacidosis (DKA) and hyperglycemic hyperosmolar state (HHS) are hyperglycemic emergencies for which children are admitted to the hospital.

Objectives/Goal: Our objective was to compare acute kidney injury (AKI) between youth with isolated DKA to those with hyperosmolarity and explore associations to risk of AKI.

Methods/Design: Charts were reviewed from 01/2019 through 12/2020 for youth admitted with DKA (serum bicarbonate ≤16 mEq/L) and/or HHS (blood glucose ≥600 mg/dL and osmolality ≥320 mOsm/kg). Isolated HHS youth were combined with hyperosmolar DKA for analysis. AKI was defined as elevated creatinine level for age. The total amount of isotonic fluids administered was …

Effects Of Caffeine On Agility Tests On One Women's Collegiate Volleyball Team, Sarah Monnier, Erika Smith-Goodwin, Eric Dick

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

OBJECTIVE
The purpose of this study was to investigate the effects of caffeine on agility tests (3-step approach,2-hand vertical leap,5-10-5 drill) on a women’s collegiate volleyball team at one Division III institution.

MAIN OUTCOME MEASUREMENT
Vertical jump measuring device measured 3-step approach and 2-hand vertical leap measurements. A stopwatch measured the 5-10-5 drill.

Effects Of Rock Steady Boxing On Parkinsons Patients, Hannah Hall, Jennifer Walker, Erika Smith-Goodwin

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

OBJECTIVE
Rock Steady Boxing’s (non-profit organization) program goal is improving Parkinson’s patients’ quality of life through a non-contact, boxing-based fitness class. The purpose of this study was to investigate the effects of Parkinson’s patients perceived improvement on proprioception from one hospital-based Rock Steady Boxing Program. The program was led by athletic trainers and physical therapists.

MAIN.OUTCOME.MEASURE
Likert scale survey was used with one fill in the blank question.

Comfort Levels Of Male Collegiate Student Athletes In Reporting Symptoms Of Eating Disorders, Maryn Herring, Erika Smith-Goodwin, Jennifer Walker

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

OBJECTIVE
The purpose of this study was to investigate the comfort levels of male student athletes at a Division III college in reporting symptoms of eating disorders to Athletic Trainers.

MAIN OUTCOME MEASUREMENT
Likert scale questions with one open ended question.

Rodeo Athletes' Perceptions Of The Available Onsite Medical Care Provided, Rachel R. Kesterson, Erika Smith-Goodwin, Jennifer Walker, Perry Denehy

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

OBJECTIVE
The purpose of this study was to investigate the medical care perceptions of rodeo athletes at one Southwest Ohio rodeo as compared to others.

MAIN.OUTCOME.MEASURE
The survey was made of 23 Likert-scale questions.

Mens' And Womens' Diii Soccer Athletes Anxiety Levels Due To Balancing Academic And Team Responsibilities, Kathleen Monnig, Jennifer Walker, Erika Smith-Goodwin

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

OBJECTIVE
The purpose of this study was to investigate anxiety levels due to balancing academic and team responsibilities in one Division III womens’ and mens’ soccer teams.

MAIN.OUTCOME.MEASURE
5-point,6-point Likert scale.

Effects Of Tiktok On The Mental Health Of Men's And Women's Soccer Teams At One Institution, Hayley Suchland, Erika Smith-Goodwin, Eric Dick

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

OBJECTIVE
The purpose of this study was to investigate the effects of the social media platform, TikTok, on the mental health of Division III Men’s and Women’s soccer players at one institution.

MAIN.OUTCOME.MEASUREMENT
Likert scale survey.

Comparison Of Rehabilitation Programs Following A Latarjet Procedure: A Level 3 Case Study, Philip Wienkamp, Lisa S. Jutte

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

OBJECTIVE
Anterior shoulder dislocations cause chronic disability, often requiring surgery. Latarjet procedures are considered when the anterior glenoid fractures during shoulder dislocation. Latarjet procedures show positive outcomes with low dislocation recurrence rates, although rehabilitation guidelines are not well established. This Level-3 CASE report will compare two rehabilitation protocols.

UNIQUENESS
Our patient’s progress was significantly delayed compared to Murphy et al.’s patient. Although they had similar strength and ROM deficits in week 2, our patient required an additional 15 weeks to make similar gains. Also, our patient did not begin aggressive overhead activity until 10 weeks after Murphy et al.’s patient. …

A 12-Year Retrospective Analysis Of Vo2max Values In College-Aged Student Athletes, Michelle Wilson, Scott Swanson

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

OBJECTIVE
To examine VO₂max values in a cohort of exercise physiology students over a 12-year time period.

MAIN OUTCOME MEASUREMENT
Student’s VO₂max values were examined for the effects of gender (males vs. females) and athletic status (athlete vs. non-athlete). Significance was set at p

Exploring The Relationship Between Athletic Identity On Certain Coping Mechanisms In Adolescent Athletes, Jessica Steger, Laura Harris

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

OBJECTIVE
(1) To describe athletic identity and coping mechanisms in an adolescent athletic population, and (2) to examine the relationship between athletic identity and coping mechanisms in an adolescent population.

MAIN.OUTCOME.MEASURES
Descriptive statistics were calculated for the summated AIMS-7 score and three CISS-SSC subscale scores. Pearson correlation coefficients were calculated between each AIMS-7 subscale and CISS-SSC subscale. Additionally, three independent t-tests were conducted with the independent variable, low, moderate, or high AIMS score, and the dependent variables, avoidance, emotion, or task-focused CISS-SSC score. Alpha level was set at 0.05 for all analyses.

Reliability And Utility Of A Lumbopelvic-Hip Complex Stability Assessment In Individuals With Patellofemoral Pain, Erika Zambarano, Neal Glaviano, Amanda Murray

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

OBJECTIVE
Lumbopelvic-hip complex (LPHC) stability is related to altered movement patterns that are present in individuals with PFP. Current studies measuring LPHC function in PFP primarily assess endurance and not stability. A test of isolated LPHC stability, the Seated Trunk Control Test (STCT) was recently developed and test-retest reliability for the STCT has been shown to be excellent in a healthy population. To improve the clinical usefulness of the STCT, we aimed to establish test-retest reliability for individuals with PFP. We hypothesized the STCT would show good-to-excellent reliability. We also compared STCT performance between healthy individuals and those with PFP. …

Caring For Pregnant And Postpartum Athletes: Athletic Trainers, Strength Coaches, And Athletic Coaches, Aly Matejka, Stephanie Born

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

OBJECTIVE
A survey was created to assess the experience, education, and self-perceived competence of treating and/or training pregnant and postpartum athletes among athletic trainers, strength coaches, and coaches.

Academic Resilience Of Athletic Training Students During Covid-19 Pandemic, Brandon J. Gallimore, Laura Harris, Janet E. Simon

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

OBJECTIVE
(1) To describe resilience in athletic training students enrolled in professional coursework during the spring 2020 semester, and (2) to determine the association between resilience and academic performance during the spring 2020 semester.

MAIN OUTCOME MEASURES
Descriptive statistics for GPA were calculated for Fall 2019, Spring 2020, cumulative Fall 2019, cumulative Spring 2020 (ie., current), change in cumulative GPA, and ARS-30 total score. The primary analysis was a Pearson correlation between change in cumulative GPA and ARS-30 total score. A secondary analysis was conducted to evaluate change in cumulative Fall 2019 and Spring 2020 GPA with a paired t-test. …

The Effects Of A 6-Week Intrinsic Foot Morphology, Kinematics, And Kinetics In Individuals With Pes Planus, Rebecca Marszalek, Janet E. Simon, Robert Wayner

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

CONTEXT
The intrinsic foot muscles are vital in supporting the medial longitudinal arch of the foot. Individuals with pes planus have poor foot morphology, strength, and biomechanics, warranting an intervention.

MAIN OUTCOME MEASURES
At pre-intervention, foot posture and arch height were assessed via the Foot Posture Index-6 and the Navicular Drop test, respectively. Cross-sectional area of the abductor hallucis was assessed using ultrasound as an indirect measure of strength. Biomechanical measures, including peak rearfoot eversion, peak tibial internal rotation, peak rearfoot eversion moment, and center of pressure excursion, were collected using 3D-motion capture and an instrumented treadmill. At post-intervention, these …

The Relationship Between Sport Specialization And Coping Mechanisms In Adolescent Athletes, Sara Kusner, Laura Harris

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

OBJECTIVE
(1) To describe the coping mechanisms of adolescent athletes as emotion-focused, problem-focused, or avoidant-focused coping before and after injury or illness, and (2) to compare the perceived adolescent coping mechanisms across sport specialization levels (i.e., low, moderate, or high).

MAIN OUTCOME MEASUREMENT
Demographic information was reported for the entire sample. A one-way ANOVA was conducted for each dependent variable (i.e., coping strategy) by sport specialization. For the secondary analysis the independent variable time and the dependent variable coping mechanism (i.e., task, emotion, and avoidance) were analyzed by paired t-tests. Hedge’s g effect size was calculated for any significant comparisons …

Adolescent Injury Rates, Laura Harris, Erin Gordon, Lyn M. Meyerhoff, Boden Miller, Matallyn E. Overmyer, Jordyn R. Williams

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

OBJECTIVE
To describe the frequency of adolescent athlete injury based upon injury location, injury diagnosis, activity, playing surface, weather condition, and sport.

MAIN.OUTCOME MEASUREMENT
Injury frequency per injury location, diagnosis, activity, and playing surface were determined. Injury location and diagnosis frequency were reported by weather condition. Injuries per 1000 athletic exposures were analyzed by sport.

Establishing Safe Thresholds To Improve Exercise Capacity In Collegiate Athletes With Inflammatory Bowel Disease (Ibd): A Critically Appraised Topic, Emily C. Roberts, Jenny Toonstra, Andrea Cripps

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

CLINICAL SCENARIO
Crohn’s Disease (CD), Ulcerative Colitis (UC), and Indeterminate Colitis (IC) are forms of Inflammatory Bowel Disease (IBD), a complex auto-immune disorder of the GI tract. IBD can present several challenges to athletic participation due to unpredictable disease activity and uncontrollable systemic symptoms that severely impact daily activities and limit exercise/sports participation. Limited studies and a lack of standard guidelines for physical activity (PA) and exercise are additional barriers for patients. The limitation of studies and absence of standard guidelines are a particular concern for Athletic Trainers who may encounter collegiate athletes with IBD and must navigate the return-to-play …

Wto: A Study Of The Pharmaceutical Sector, Khushal Bhargava

Management Dynamics

No abstract provided.