Medicine and Health Sciences Commons^™

Identification Of Acenkps, A Committed Common Progenitor Population Of The Ilc1 And Nk Cell Continuum, Noe Rodriguez-Rodriguez, Paula A Clark, Mayuri Gogoi, Ana C F Ferreira, Bernhard Kerscher, Alastair Crisp, Helen E Jolin, Jane E Murphy, Meera Sivasubramaniam, Luisa Pedro, Jennifer A Walker, Morgan W D Heycock, Jacqueline D Shields, Jillian L Barlow, Andrew N J Mckenzie

Faculty, Staff and Student Publications

The development of innate lymphoid cell (ILC) transcription factor reporter mice has shown a previously unexpected complexity in ILC hematopoiesis. Using novel polychromic mice to achieve higher phenotypic resolution, we have characterized bone marrow progenitors that are committed to the group 1 ILC lineage. These common ILC1/NK cell progenitors (ILC1/NKP), which we call "aceNKPs", are defined as lineage-Id2+IL-7Rα+CD25-α4β7-NKG2A/C/E+Bcl11b-. In vitro, aceNKPs differentiate into group 1 ILCs, including NK-like cells that express Eomes without the requirement for IL-15, and produce IFN-γ and perforin upon IL-15 stimulation. Following reconstitution of Rag2-/-Il2rg-/- hosts, aceNKPs give rise to a spectrum of mature ILC1/NK cells …

Popdc1 Scaffolds A Complex Of Adenylyl Cyclase 9 And The Potassium Channel Trek-1 In Heart, Tanya A Baldwin, Yong Li, Autumn N Marsden, Susanne Rinné, Anibal Garza-Carbajal, Roland F R Schindler, Musi Zhang, Mia A Garcia, Venugopal Reddy Venna, Niels Decher, Thomas Brand, Carmen W Dessauer

Faculty, Staff and Student Publications

The establishment of macromolecular complexes by scaffolding proteins is key to the local production of cAMP by anchored adenylyl cyclase (AC) and the subsequent cAMP signaling necessary for cardiac functions. We identify a novel AC scaffold, the Popeye domain-containing (POPDC) protein. The POPDC family of proteins is important for cardiac pacemaking and conduction, due in part to their cAMP-dependent binding and regulation of TREK-1 potassium channels. We show that TREK-1 binds the AC9:POPDC1 complex and copurifies in a POPDC1-dependent manner with AC9 activity in heart. Although the AC9:POPDC1 interaction is cAMP-independent, TREK-1 association with AC9 and POPDC1 is reduced upon …

A Unified Model Of Age-Related Cardiovascular Disease, Michael Fossel, Joe Bean, Nina Khera, Mikhail G Kolonin

Faculty, Staff and Student Publications

Despite progress in biomedical technologies, cardiovascular disease remains the main cause of mortality. This is at least in part because current clinical interventions do not adequately take into account aging as a driver and are hence aimed at suboptimal targets. To achieve progress, consideration needs to be given to the role of cell aging in disease pathogenesis. We propose a model unifying the fundamental processes underlying most age-associated cardiovascular pathologies. According to this model, cell aging, leading to cell senescence, is responsible for tissue changes leading to age-related cardiovascular disease. This process, occurring due to telomerase inactivation and telomere attrition, …

Plasma Growth Hormone Is A Potential Biomarker Of Response To Atezolizumab And Bevacizumab In Advanced Hepatocellular Carcinoma Patients, Yehia I Mohamed, Dan G Duda, Muhammad O Awiwi, Sunyoung S Lee, Lina Altameemi, Lianchun Xiao, Jeffrey S Morris, Robert A Wolff, Khaled M Elsayes, Rikita I Hatia, Aliya Qayyum, Shadi M Chamseddine, Asif Rashid, James C Yao, Armeen Mahvash, Manal M Hassan, Hesham M Amin, Ahmed Omar Kaseb

Faculty, Staff and Student Publications

INTRODUCTION: Hepatocellular carcinoma (HCC) has limited systemic therapy options when discovered at an advanced stage. Thus, there is a need for accessible and minimally invasive biomarkers of response to guide the selection of patients for treatment. This study investigated the biomarker value of plasma growth hormone (GH) level as a potential biomarker to predict outcome in unresectable HCC patients treated with current standard therapy, atezolizumab plus bevacizumab (Atezo/Bev).

MATERIALS AND METHODS: Study included unresectable HCC patients scheduled to receive Atezo/Bev. Patients were followed to determine progression-free survival (PFS) and overall survival (OS). Plasma GH levels were measured by ELISA and …

Modulation Of Sirtuins During Monolayer Chondrocyte Culture Influences Cartilage Regeneration Upon Transfer To A 3d Culture Environment, Hannah K Heywood, Stephen D Thorpe, Renos M Jeropoulos, Paul W Caton, David A Lee

Faculty, Staff and Student Publications

This study examined the role of sirtuins in the regenerative potential of articular chondrocytes. Sirtuins (SIRT1-7) play a key role in regulating cartilage homeostasis. By inhibiting pro-inflammatory pathways responsible for cartilage degradation and promoting the expression of key matrix components, sirtuins have the potential to drive a favourable balance between anabolic and catabolic processes critical to regenerative medicine. When subjected to osmolarity and glucose concentrations representative of the in vivo niche, freshly isolated bovine chondrocytes exhibited increases in SIRT1 but not SIRT3 gene expression. Replicating methods adopted for the in vitro monolayer expansion of chondrocytes for cartilage regenerative therapies, we …

Author Correction: Disrupted Ca2+ Homeostasis And Immunodeficiency In Patients With Functional Ip3 Receptor Subtype 3 Defects, Julika Neumann, Erika Van Nieuwenhove, Lara E Terry, Frederik Staels, Taylor R Knebel, Kirsten Welkenhuyzen, Kourosh Ahmadzadeh, Mariah R Baker, Margaux Gerbaux, Mathijs Willemsen, John S Barber, Irina I Serysheva, Liesbeth De Waele, François Vermeulen, Susan Schlenner, Isabelle Meyts, David I Yule, Geert Bultynck, Rik Schrijvers, Stephanie Humblet-Baron, Adrian Liston

Faculty, Staff and Student Publications

This corrects the article "Disrupted Ca²⁺ homeostasis and immunodeficiency in patients with functional IP₃ receptor subtype 3 defects" on page 11.

Acetyl-Coa-Mediated Autoacetylation Of Fatty Acid Synthase As A Metabolic Switch Of De Novo Lipogenesis In Drosophila, Ting Miao, Jinoh Kim, Ping Kang, Hideji Fujiwara, Fong-Fu Hsu, Hua Bai

2020-Current year OA Pubs

De novo lipogenesis is a highly regulated metabolic process, which is known to be activated through transcriptional regulation of lipogenic genes, including fatty acid synthase (FASN). Unexpectedly, we find that the expression of FASN protein remains unchanged during

Future Newborns With Opioid-Induced Neonatal Abstinence Syndrome (Nas) Could Be Assessed With The Genetic Addiction Risk Severity (Gars) Test And Potentially Treated Using Precision Amino-Acid Enkephalinase Inhibition Therapy (Kb220) As A Frontline Modality Instead Of Potent Opioids, Mauro Ceccanti, Mark S Gold, Et Al.

2020-Current year OA Pubs

In this nonsystematic review and opinion, including articles primarily selected from PubMed, we examine the pharmacological and nonpharmacological treatments of neonatal abstinence syndrome (NAS) in order to craft a reasonable opinion to help forge a paradigm shift in the treatment and prevention of primarily opioid-induced NAS. Newborns of individuals who use illicit and licit substances during pregnancy are at risk for withdrawal, also known as NAS. In the US, the reported prevalence of NAS has increased from 4.0 per 1000 hospital births in 2010 to 7.3 per 1000 hospital births in 2017, which is an 82% increase. The management of …

Unfavorable Social Determinants Of Health Are Associated With Higher Burden Of Financial Toxicity Among Patients With Atherosclerotic Cardiovascular Disease In The Us: Findings From The National Health Interview Survey, Javier Valero-Elizondo, Zulqarnain Javed, Rohan Khera, Mauricio E Tano, Ramzi Dudum, Isaac Acquah, Adnan A Hyder, Julia Andrieni, Garima Sharma, Michael J Blaha, Salim S Virani, Ron Blankstein, Miguel Cainzos-Achirica, Khurram Nasir

Faculty, Staff and Students Publications

• D: PMC9727868

Mechanisms Of Irf2bpl-Related Disorders And Identification Of A Potential Therapeutic Strategy, Shrestha Sinha Ray, Debdeep Dutta, Cassandra Dennys, Samantha Powers, Florence Roussel, Pawel Lisowski, Petar Glažar, Xiaojin Zhang, Pipasha Biswas, Joseph R Caporale, Nikolaus Rajewsky, Marc Bickle, Nicolas Wein, Hugo J Bellen, Shibi Likhite, Paul C Marcogliese, Kathrin C Meyer

Faculty, Staff and Students Publications

The recently discovered neurological disorder NEDAMSS is caused by heterozygous truncations in the transcriptional regulator IRF2BPL. Here, we reprogram patient skin fibroblasts to astrocytes and neurons to study mechanisms of this newly described disease. While full-length IRF2BPL primarily localizes to the nucleus, truncated patient variants sequester the wild-type protein to the cytoplasm and cause aggregation. Moreover, patient astrocytes fail to support neuronal survival in coculture and exhibit aberrant mitochondria and respiratory dysfunction. Treatment with the small molecule copper ATSM (CuATSM) rescues neuronal survival and restores mitochondrial function. Importantly, the in vitro findings are recapitulated in vivo, where co-expression of full-length …

The Rheumatoid Arthritis Drug Auranofin Lowers Leptin Levels And Exerts Antidiabetic Effects In Obese Mice, Aaron R Cox, Peter M Masschelin, Pradip K Saha, Jessica B Felix, Robert Sharp, Zeqin Lian, Yan Xia, Natasha Chernis, David A Bader, Kang Ho Kim, Xin Li, Jun Yoshino, Xin Li, Gang Li, Zheng Sun, Huaizhu Wu, Cristian Coarfa, David D Moore, Samuel Klein, Kai Sun, Sean M Hartig

Faculty, Staff and Student Publications

Low-grade, sustained inflammation in white adipose tissue (WAT) characterizes obesity and coincides with type 2 diabetes mellitus (T2DM). However, pharmacological targeting of inflammation lacks durable therapeutic effects in insulin-resistant conditions. Through a computational screen, we discovered that the FDA-approved rheumatoid arthritis drug auranofin improved insulin sensitivity and normalized obesity-associated abnormalities, including hepatic steatosis and hyperinsulinemia in mouse models of T2DM. We also discovered that auranofin accumulation in WAT depleted inflammatory responses to a high-fat diet without altering body composition in obese wild-type mice. Surprisingly, elevated leptin levels and blunted beta-adrenergic receptor activity achieved by leptin receptor deletion abolished the antidiabetic …

A Statistical Machine Learning Method To Handle Missing Phq-8 Score Data In The Uaehfs Pilot Data – A Bayesian Network Approach, Mitha Al Balushi, A. Ahmad, S. Javaid, L. Ahmed, M. Grivna, F. Al Maskari, A. Abdulle, R. Ali

The First Scientific Conference on Health and Medical Research in the UAE 5-6 December 2022

No abstract provided.

Pathway-Based Analysis And Artificial Intelligence Reveals Metabolic Subtypes Of Clinical Relevance In Breast Cancer, Mohammad Askandar Iqbal

The First Scientific Conference on Health and Medical Research in the UAE 5-6 December 2022

No abstract provided.

Role Of Artificial Intelligence For Self-Triage Systems Of Safe Increase Of Ambulance Resource Efficiency, Tanveer Ahmed Yadgir, Tamas Madl, Omer Al Sakaf

The First Scientific Conference on Health and Medical Research in the UAE 5-6 December 2022

No abstract provided.

An Artificial Intelligence (Ai) Model For Prediction Of Covid 19 Infection Risk In The Uae Population, Sara Alshaya, Sheik Abdullah Jamal Mohideen, Aji Gopakumar, Vibhor Mathur

The First Scientific Conference on Health and Medical Research in the UAE 5-6 December 2022

No abstract provided.

Evaluation Of Rotenone Mediated Α-Synuclein Spreading And Neurotoxicity In Α-Synuclein Pff Induced Animal Model Of Parkinson’S Disease, Engila Khan, Mustafa Ardah, M. Emdadul Haque

The First Scientific Conference on Health and Medical Research in the UAE 5-6 December 2022

No abstract provided.

Impact Of Working During Covid19 On The Mental Health Of Health Care Workers In A Hospital In Sharjah, Uae, Jayakumary Muttappallymyalil, Shaikha Fawaghi Almualla

The First Scientific Conference on Health and Medical Research in the UAE 5-6 December 2022

No abstract provided.

Drug Development Against Covid-19, Wael M. Rabeh, Juliana C. Ferreira, Samar Fadl

The First Scientific Conference on Health and Medical Research in the UAE 5-6 December 2022

No abstract provided.

Cervical Muscle Strength And Kinematics During An Unanticipated Perturbation In University Aged Male And Female Rugby Athletes, Abigail Ruppert, Lauren J. Lattimer

Journal for Sports Neuroscience

Introduction: Female athletes participating in contact sports demonstrate a concussion injury risk factor that is two times greater than their age-matched male counterparts. Recent literature has outlined the importance of neck muscle strength and neuromuscular characteristics in the mitigation of excessive head kinematics. Rugby is a contact sport in which tackles comprise the mechanism for concussion, which is caused by inertial impacts. Females exhibit higher measurements of acceleration and investigating potential gender differences in dynamic stabilization of the head is warranted in rugby. Methods: Twenty-three (15 female, 8 male) university-aged rugby athletes participated in kinematic analysis; and a series of …

Ace2 Variation And Trafficking In The Pathogenesis Of Sars-Cov-2, Nesreen Al-Khofash

The First Scientific Conference on Health and Medical Research in the UAE 5-6 December 2022

No abstract provided.

Post-Vaccination Induced-Immune Response To Anti-Sars-Cov-2 Igg Antibodies And T-Cells Surrogate Markers By Type And Vaccination Regime: A Retrospective Cohort Study, R. H. Al-Rifai, F. Al Housani, R.M. Abuyadek, S. Atef, J. Donnelly, A. Jabari, L. A. Ahmed, B. Altrabulsi, A. Alatoom, A. Al Suwaidi, L. Abdelwareth

The First Scientific Conference on Health and Medical Research in the UAE 5-6 December 2022

No abstract provided.

A Retrospective Chart Review Of Pediatric Complicated Community-Acquired Pneumonia: An Experience In The Al Qassimi Women And Children Hospital, Sinan Yavuz, Amal Sherif, Maryam Amirrad, Khalid Sabet, Mohamed Hassan, Motasem Abuelreish, Noura Langawi, Mina Almanasir, Nader Francis

The First Scientific Conference on Health and Medical Research in the UAE 5-6 December 2022

No abstract provided.

Phactr1 & Lpl Mediate Restenosis Risk In Cad Patients, Cynthia Al Hageh, Stephanie Chacar, Thenmozhi Vankatchalam, Dominique Gauguier, Antoine Abchee, Elie Chammas, Hamdan Hamdan, Sioban O'Sullivan O'Sullivan, Pierre Zalloua, Moni Nader

The First Scientific Conference on Health and Medical Research in the UAE 5-6 December 2022

No abstract provided.

The Role Of Bcl3 Dysregulation In The Pathogenesis Of Asthma And Lung Cancer, Laila Salameh, Poorna Manasa Bhamidimarri, Noha Elemam, Rakhee K. Ramakrishnan, Qutayba Hamid, Bassam Mahboub, Saba Al Heialy, Rifat Hamoudi

The First Scientific Conference on Health and Medical Research in the UAE 5-6 December 2022

No abstract provided.

The Mutaba’Ah Study: A Cohort Profile Of The Largest Mother And Child Cohort Study In The United Arab Emirates, Luai A. Ahmed, Zufishan Alam, Iffat Elbarazi, Fatima Al-Maskari, Rami H. Al-Rifai, Tom Loney

The First Scientific Conference on Health and Medical Research in the UAE 5-6 December 2022

No abstract provided.

Saudi Heart Association Guidelines On Best Practices In The Management Of Chronic Coronary Syndromes, Owayed Alshammeri, Shukri Al Saif, Halia Al Shehri, Mirvat Alasng, Fatema Qaddoura, Mohammad Al Shehri, Yosra Turkistani, Adel Tash, Walid Alharbi, Fahad Al Qahtani, Rafael Diaz, Wael Mahaimeed, Waleed Al Habeeb, Khalid Alfaraidy

Journal of the Saudi Heart Association

Background: The prevalence of both chronic coronary syndrome (CCS) and its risk factors is alarming in Saudi Arabia and only a minority of patients achieve optimal medical management. Context-specific CCS guidelines outlining best clinical practices are therefore needed to address local gaps and challenges. Consensus panel: A panel of experts representing the Saudi Heart Association (SHA) reviewed existing evidence and formulated guidance relevant to local clinical practice considering the characteristics of the Saudi population, the Saudi healthcare system, its resources and medical expertise. They were reviewed by external experts to ensure scientific and medical accuracy. Consensus findings: Recommendations are provided …

2022-12-05_Michiganoverview_Covidoutbreak, Michigan Department Of Health & Human Services

Michigan COVID-19 Outbreak Reports

The Outbreak Data page was obtained from Michigan's COVID-19 data page: https://www.michigan.gov/coronavirus/stats/outbreak-reporting.

This report is created by the Michigan Department of Health & Human Services from data self-reported by local health departments. Data is updated every week.

COVID-19 outbreaks are generally defined as two or more cases with a link by place and time indicating a shared exposure outside of a household. Local health departments report the number of new and ongoing outbreaks they are investigating by the setting of the outbreak. New outbreaks are those outbreaks that were first identified during the current reporting week. Ongoing outbreaks are …

The Walking Well: Effects Of Hypothalamic Amenorrhea On Athletic Performance, Annalise H. Lau, Erica Barber, Justin Gambini

Doctor of Medical Science (DMSc)

Hormonal balance and normal menstrual cycles are key factors in athletic performance. Unfortunately, female athletes themselves are often under the impression that a lighter weight will improve their performance. Even many healthcare providers do not emphasize or are unaware of the health consequences of prolonged irregular menstruation. The main purpose of this article is to review the health consequences hypothalamic amenorrhea has on female athletes and to provide education for healthcare providers regarding the importance of recovery. A literature search was conducted utilizing PubMed, Scopus, PLOS One and EBSCO. The following keywords were input into the search bar: hypothalamic amenorrhea, …

2022-12-05_Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services

Michigan COVID-19 Hospital Data

Contains the tables Statewide Hospital Capacity Report for COVID-19, COVID-19 Metrics, Statewide Hospital Available PPE Tracking for COVID-19, as well as the tables PPE Days On Hand and Patient Census.

Examining The Barriers, Facilitators And Attitudes Towards Covid-19 Vaccine And Public Health Measures For Black Communities In Canada: A Qualitative Study Protocol., Obidimma Ezezika, Bethelehem Girmay, Toluwalope Adedugbe, Isaac Jonas, Yanaminah Thullah, Chris Thompson

Health Studies Publications

INTRODUCTION: Black communities claim the highest number of cases and deaths due to COVID-19 in Canada. Generating culturally/contextually appropriate public health measures and strategies for vaccine uptake in black communities within Canada can better support the disproportionate impact of this pandemic. This study explores the barriers and enablers to public health measures limited to mask-wearing, disinfection, sanitation, social distancing and handwashing, as well as the barriers and attitudes towards COVID-19 vaccines among the black community.

METHODS AND ANALYSIS: We will use qualitative approaches informed by the widely accepted Consolidated Framework for Implementation Research (CFIR) to aid our investigation. We will …