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2022

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Articles 10291 - 10320 of 23792

Full-Text Articles in Medicine and Health Sciences

Recombinant Scfv Inhibit Newcastle Disease Virus In Vitro Infection, Sanfeng Peng, Lintian Yu, Ying He, Dongyang Chen, Li Wang, Xueliang Zhou, Long Xie, Yangqing Lu Jun 2022

Recombinant Scfv Inhibit Newcastle Disease Virus In Vitro Infection, Sanfeng Peng, Lintian Yu, Ying He, Dongyang Chen, Li Wang, Xueliang Zhou, Long Xie, Yangqing Lu

The Thai Journal of Veterinary Medicine

Newcastle disease (ND) is an avian respiratory disease caused by the Newcastle disease virus (NDV) and is prevalent worldwide but lacks a reliable treatment to surmount it. The single-chain fragment variable (scFv) antibody is the smallest functional unit in an immunoglobulin retaining antigen-binding activities. Previous studies have demonstrated that by acting against the NDV phosphoprotein, scFv is capable of neutralizing the virus in infected cells. In this study, two anti-NDV scFv expressing cassettes driven by CAG promoter and EF1α promoter, respectively, were constructed using the piggyBac transposon plasmid backbone. The recombinant plasmids were transfected into DF-1 and 293T cells and …

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Genomic And Phylogenetic Analysis Of The Orf7b Gene From A Chinese Feline Infectious Peritonitis Virus Isolate, Bo Dong, Bo Dong, Xiaodong Zhang, Xiaodong Zhang, Yafei Song, Chengyu Li, Gaoqiang Zhang, Weiming Lin Jun 2022

Genomic And Phylogenetic Analysis Of The Orf7b Gene From A Chinese Feline Infectious Peritonitis Virus Isolate, Bo Dong, Bo Dong, Xiaodong Zhang, Xiaodong Zhang, Yafei Song, Chengyu Li, Gaoqiang Zhang, Weiming Lin

The Thai Journal of Veterinary Medicine

FCoV viruses exhibit great genetic diversity, leading to the presence of FIPV-causing variants. Current molecular evolution analysis and genetic variation studies of FCoV in China are predominately focused on gene encoding the spike protein or other structural proteins, while few studies have evaluated genetic variations in nonstructural FCoV genes, which can play an important role in disease pathogenesis. In this study, the gene encoding the open reading frame (ORF) 7b nonstructural FCoV protein of the Chinese Fujian strain FJLY20201 was amplified from the ascitic fluid of a Chinese domestic cat infected with FIPV and compared with ORF 7b from previously …

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Occurrence And Characteristics Of Salmonella Isolated From Various Vegetable Sources: Potential For The Human-Food Interface In Salmonellosis In Vientiane, The Capital Of Laos Pdr, Dethaloun Meunsene, Thanaporn Eiamsam-Ang, Prapas Patchanee, Ratchadaporn Boripun, Phacharaporn Tadee, Sayaphet Rattanavong, Manivanh Vongsouvath, Pakpoom Tadee Jun 2022

Occurrence And Characteristics Of Salmonella Isolated From Various Vegetable Sources: Potential For The Human-Food Interface In Salmonellosis In Vientiane, The Capital Of Laos Pdr, Dethaloun Meunsene, Thanaporn Eiamsam-Ang, Prapas Patchanee, Ratchadaporn Boripun, Phacharaporn Tadee, Sayaphet Rattanavong, Manivanh Vongsouvath, Pakpoom Tadee

The Thai Journal of Veterinary Medicine

Salmonella is one of the most frequently reported causes of bacterial foodborne outbreaks in the world. Despite this, cases associated with raw vegetable consumption have increased, however very few studies have focused on this. The present study is an overview of the role of vegetables as a concern for Salmonella circulating in Vientiane, the capital of the Lao People's Democratic Republic (Lao PDR). A cross-sectional study was surveyed during the first half 2019 on various types of vegetable sold in retailers in the area. The prevalence, serotype, antimicrobial resistance pattern and genetic profile of Salmonella were investigated. In this study, …

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Yield, Composition, Fatty Acid Profile And Cla Content Of Milk From Goats Fed With Different Levels Of Opf, Pitunart Noosen, Ulia Renfelia Baysi Jun 2022

Yield, Composition, Fatty Acid Profile And Cla Content Of Milk From Goats Fed With Different Levels Of Opf, Pitunart Noosen, Ulia Renfelia Baysi

The Thai Journal of Veterinary Medicine

The objective of this study was to evaluate the effect of different inclusion levels of OPF in total mixed ration (TMR)-based diet on yield, composition, FA profile and CLA content of milk in dairy goats. Six nulliparous female dairy goats (Saanen x Thai native, 19-21 months old, first lactation) were randomly set according to a 3x3 Latin square design with 2 replications for receiving diets consisted of 0% OPF (OPF0), 20% OPF (OPF20) and 40% OPF (OPF40). The average weight of the goats was 32.48±1.30 kg (mean±s.d.). The findings of this study showed that dry matter intake (DMI) and all …

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Inconsistent And Multiple Bacterial Species From Different Sample Types Of Dogs With Urolithiasis And Bacterial Cystitis, Nantapatt Pridsadangbud, Chantamanee Chantarasiri, Nattanit Visitkitjakarn, Phitsinee Tantivimonkajor, Jitrapa Yindee, Nicole Sirisopit Mehl Jun 2022

Inconsistent And Multiple Bacterial Species From Different Sample Types Of Dogs With Urolithiasis And Bacterial Cystitis, Nantapatt Pridsadangbud, Chantamanee Chantarasiri, Nattanit Visitkitjakarn, Phitsinee Tantivimonkajor, Jitrapa Yindee, Nicole Sirisopit Mehl

The Thai Journal of Veterinary Medicine

Urinary tract infection is the most common complication found in dogs with urolithiasis. Bacterial cystitis can play an important role in dogs with urolithiasis; it can either be the cause of cystic formation or be a complication following urolithiasis. Moreover, urolithiasis cases that come with bacterial cystitis can lead to a condition of complicated cystitis which will require more complicated treatment and management. Proper bacterial identification should be performed in order to follow an appropriate treatment. Specific treatments require bacterial identification in order to select the most appropriate antibiotics. There are three main possible sites for bacterial sample collection in …

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Detection And Phylogenetic Analysis Of Porcine Epidemic Diarrhea Virus Based On The Orf3 Gene In Pigs In The North Of Vietnam, Tran Duc Hoan, Doan Thi Thao, Nguyen Thi Huong Giang, Nguyen Thi Thu Huyen, Nguyen Thi Thu Huyen Jun 2022

Detection And Phylogenetic Analysis Of Porcine Epidemic Diarrhea Virus Based On The Orf3 Gene In Pigs In The North Of Vietnam, Tran Duc Hoan, Doan Thi Thao, Nguyen Thi Huong Giang, Nguyen Thi Thu Huyen, Nguyen Thi Thu Huyen

The Thai Journal of Veterinary Medicine

To identify further the infectivity, genetic diversity and molecular characteristics of the porcine epidemic diarrhea virus (PEDV). 286 samples of the intestinal tissue of pigs with severe diarrhea were assessed from 5 provinces in the north of Vietnam. The full-length ORF3 gene of 20 representative field strains from 36 farms in 5 provinces was sequenced and analyzed. The prevalence of PEDV was 90.56% and was detected in 259 of 286 samples, with 94.44% (34 of 36) of pig farms harboring the disease. Based on the phylogenetic analysis of the ORF3 genes, our isolates all fell into group G2 (variants) and …

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Distribution Of Salmonella Spp. And Serovars Isolated From Captive Reptiles In Four Zoos Of The Zoological Park Organization, Thailand, Between 2017 And 2018, Sompoth Weerakhun, Paweena Kongsanan, Wichit Kongkham Jun 2022

Distribution Of Salmonella Spp. And Serovars Isolated From Captive Reptiles In Four Zoos Of The Zoological Park Organization, Thailand, Between 2017 And 2018, Sompoth Weerakhun, Paweena Kongsanan, Wichit Kongkham

The Thai Journal of Veterinary Medicine

Salmonellosis is the main reason for food borne diseases in many countries globally and it has been found that reptiles are carriers of the disease. Therefore, this study was performed to determine the distribution of Salmonella spp. and their serovars from reptiles in zoos in Thailand between 2017 and 2018. A total of 257 reptile samples were collected from four zoos which are Dusit (128 samples), Chiangmai (32 samples), Songkhla (34 samples) and Nakhonratchasima (63 samples). Salmonella was isolated and identified, serotyping of those isolates was investigated using a panel of Salmonella antisera and serotypes were characterized according to the …

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Investigation Of The Microstructure And Mechanical Properties Of The Domestic Cat’S Paw Pads, Ye Mei Jun 2022

Investigation Of The Microstructure And Mechanical Properties Of The Domestic Cat’S Paw Pads, Ye Mei

The Thai Journal of Veterinary Medicine

Domestic cats have a biological function such as cushioning when they are jumping or walking which is mainly due to the biological coupling system formed in the long-term evolution process of nature, including the trunk-leg-paw pad structure. Among them, the paw pad, as the only part of the body that directly contacts with the ground in the process of movement, plays a key role in its biological function. Hence, in order to clarify the micro structure, mechanical properties and functional characteristics of the paw pad and reveal the relationship between it and the domestic cat’s biological function, this paper has …

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Optimal Infusion Rate Of Hypertonic Saline To Encephalic Vessel Vasodilatation Using Magnetic Resonance Imaging In Normovolemic Dogs, Yoshiki Murakami, Kenji Tsukano, Haruyuki Hirata, Hiroshi Koie, Kazuyuki Suzuki Jun 2022

Optimal Infusion Rate Of Hypertonic Saline To Encephalic Vessel Vasodilatation Using Magnetic Resonance Imaging In Normovolemic Dogs, Yoshiki Murakami, Kenji Tsukano, Haruyuki Hirata, Hiroshi Koie, Kazuyuki Suzuki

The Thai Journal of Veterinary Medicine

This study aimed to investigate, using magnetic resonance imaging, whether continuous hypertonic saline (HSS) infusion induces a superior vasodilating effect on the encephalic vessels compared to bolus infusion in dogs. The relative cross-sectional area of superior sagittal sinus increased to 1.96±0.09 and 1.69±0.31 times of the pre-value in the continuous and bolus groups, respectively, at t=30 min (p<0.001). However, the relative cross-sectional area of superior sagittal sinus was larger in the continuous group than that in the bolus group (p<0.001). The results suggest that continuous infusion of HSS might be superior to bolus infusion in inducing vasodilatation of the encephalic circulation.

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Oxygenated Dressing Quickens Skin Wound Healing Of Bama Miniature Pigs, Yingqiu Wang, Limin Qiao, Hong An, Zhenhao Zhang, Yan Zheng, Chang Chen, Jingrui Zhang, Xiangguo Wang Jun 2022

Oxygenated Dressing Quickens Skin Wound Healing Of Bama Miniature Pigs, Yingqiu Wang, Limin Qiao, Hong An, Zhenhao Zhang, Yan Zheng, Chang Chen, Jingrui Zhang, Xiangguo Wang

The Thai Journal of Veterinary Medicine

Oxygen is a vital factor in the process of wound healing and is involved in collagen synthesis, synthesis and the release of growth factors, angiogenesis and epidermal cell contraction. Hence, local oxygen control of wounds plays an important role in skin wound healing. Herein, we developed a novel oxygenated dressing for the treatment of skin wound healing in Bama miniature pigs. The oxygenated dressing was mainly composed of potassium iodide, glucose, glucose oxidase, polyvinyl alcohol, polypropylene, polyvinylpyrrolidone and water. The oxygenated dressing significantly quickens the healing of full-thickness skin wounds in Bama miniature pigs and promotes the proliferation of epidermal …

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Supplementation Of Extracellular Adenosine 5'-Triphosphate Improves Sperm Post-Thawed Quality In Thai Native Chickens, Phakjira Sanguansook, Junpen Suwimonteerabutr, Kaywalee Chatdarong Jun 2022

Supplementation Of Extracellular Adenosine 5'-Triphosphate Improves Sperm Post-Thawed Quality In Thai Native Chickens, Phakjira Sanguansook, Junpen Suwimonteerabutr, Kaywalee Chatdarong

The Thai Journal of Veterinary Medicine

Thai native chicken meat is a high-quality protein source of unique flavor. Genetic preservation and breeding programs are beneficial to maintain purebred populations. Aiming at improving post-thawed sperm quality, this study is the first to apply extracellular adenosine 5'-triphosphate (ATPe) in freezing extender to preserve Thai native chicken sperm. Eight semen samples from eight Thai native chickens (n = 8) were included. Initial semen evaluation and sperm size measurement were performed. Beltsville poultry semen extender supplemented with 0 and 30 mM ATPe was served as a control and treatment group, respectively. After thawing, motility and motion characteristics were evaluated by …

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Diagnostic Imaging And Hematological And Cytological Analyses Play A Vital Role In Clinical Investigation And Selection Of Therapeutic Approaches In A Polo Pony With Septic Olecranon Bursitis, Rungrueang Yodsheewan, Ravisara Limsripan, Metha Chanda Jun 2022

Diagnostic Imaging And Hematological And Cytological Analyses Play A Vital Role In Clinical Investigation And Selection Of Therapeutic Approaches In A Polo Pony With Septic Olecranon Bursitis, Rungrueang Yodsheewan, Ravisara Limsripan, Metha Chanda

The Thai Journal of Veterinary Medicine

A 19-year-old gelding polo pony was presented with a prominent protuberance at the tip of the right elbow and five days later, developed a marked swelling on the entire right foreleg with a high fever. Ultrasonography, performed on the caudal elbow region, demonstrated heterogeneous echogenic materials encapsulated in the fibrous capsule. The initial hematological analysis revealed anemia and a normal white blood count (WBC). Hyperbilirubinemia was detected biochemically. Pale yellow/turbid fluid was aspirated from the protuberance area, which showed septic exudate characteristics and contained Streptococcus spp. The pony was diagnosed with septic olecranon bursitis associated with streptococcal infection. The fluid-filled …

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Stifle Joint Reconstruction Technique Using Fascia Lata In A Cat With Cranial Cruciate Ligament Rupture, Hern-Yeu Lee, Wei-Yau Shia, Tien-Huan Hsu, Wei-Ming Lee Jun 2022

Stifle Joint Reconstruction Technique Using Fascia Lata In A Cat With Cranial Cruciate Ligament Rupture, Hern-Yeu Lee, Wei-Yau Shia, Tien-Huan Hsu, Wei-Ming Lee

The Thai Journal of Veterinary Medicine

A two-year-old spayed female mongrel cat presenting with right hind limb lameness with intermittent weight bearing while walking was taken to the veterinary medicine teaching hospital of National Chung Hsing University. Both drawer test and tibial compression test were positive, stifle radiography showed synovial fluid had become more radiopaque. The tentative diagnosis for the cat was rupture of the right cranial cruciate ligament (CrCL), medical management using corticosteroids was prescribed with anticoagulants and surgical treatment recommended. Intracapsular reconstruction was performed and the postoperative recovery of this cat presented normal physical status with improved right hind limb weight-bearing activity. This report …

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Mycotic Pyogranulomatous Enteritis In A German Shepherd: Imaging Diagnosis And Treatment, Phasamon Saisawart, Somchin Sutthigran, Apichart Srifawattana, Onjira Mitroupathum, Tanhatai Krajarngjang, Anudep Rungsipipat, Nan Choisunirachon Jun 2022

Mycotic Pyogranulomatous Enteritis In A German Shepherd: Imaging Diagnosis And Treatment, Phasamon Saisawart, Somchin Sutthigran, Apichart Srifawattana, Onjira Mitroupathum, Tanhatai Krajarngjang, Anudep Rungsipipat, Nan Choisunirachon

The Thai Journal of Veterinary Medicine

A five-year old, intact male, German Shepherd dog was presented to the hospital due to a history of depression, anorexia, vomiting and diarrhea. Physical examination revealed moderate emaciation and showed mild abdominal pain when Palpation. Abdominal radiographs and ultrasounds showed the distension of the small bowel loop due to partial obstruction of the colon by mural concentric thickening. Computed tomography (CT) scan showed an homogeneous, soft tissue mass with asymmetric thickening of the cecum traversing the colonic wall. Pre-operative blood profiles indicated normocytic normochromic mild anemia, hypoalbuminemia and mild hyperglobulinemia. Intestinal resection and anastomosis at the distal ileum to the …

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Feline Inductive Odontogenic Tumor In A Young Cat, Chakkarin Satthathum, Sunee Kunakornsawat, Chaiyan Kasorndorkbua Jun 2022

Feline Inductive Odontogenic Tumor In A Young Cat, Chakkarin Satthathum, Sunee Kunakornsawat, Chaiyan Kasorndorkbua

The Thai Journal of Veterinary Medicine

A 6-month-old, 4.45 kg, intact, male domestic shorthair cat was presented with a gingival mass located on the left rostral maxilla and second left upper premolar tooth. Intraoral x-ray of the left rostral maxilla revealed left maxilla bone lysis with a unilocular cystic lesion. The cytology result revealed an epithelial cell tumor .A left rostral maxillectomy was performed and the tumor was submitted for histological assessment .Histopathological diagnosis of the tissue revealed a feline inductive odontogenic tumor .There was no evidence of tumor recurrence 24 months after surgery.

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Gangliosidoses In Cats, Latticha Pluemhathaikij, Waruntip Bunyaputikul, Katriya Chankow, Benchaphorn Limcharoen, Nardtiwa Chaivoravitsakul, Rampaipat Penchome, Sawang Kesdangsakonwut, Kasem Rattanapinyopituk, Wijit Banlunara Jun 2022

Gangliosidoses In Cats, Latticha Pluemhathaikij, Waruntip Bunyaputikul, Katriya Chankow, Benchaphorn Limcharoen, Nardtiwa Chaivoravitsakul, Rampaipat Penchome, Sawang Kesdangsakonwut, Kasem Rattanapinyopituk, Wijit Banlunara

The Thai Journal of Veterinary Medicine

Two 3-month-old, male, domestic short hair, cats of the same litter were presented to the small animal teaching hospital with the clinical sign of head tremor for 2 weeks. Three months later, the clinical sign had worsened. Both kittens had loss of balance and showed intention tremor. Physical examination revealed hypertelorism, depressed bridge of the nose and back pain. Radiography showed shortened cervicothoracic vertebral bodies. Both kittens died at 8 and 9 months of age, case no.1 and 2 respectively. Both carcasses were submitted for necropsy. Both brains were grossly normal. The costal cartilages of both cats were deformed into …

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Epidemiological Association Of Cannabinoid- And Drug- Exposures And Sociodemographic Factors With Limb Reduction Defects Across Usa 1989–2016: A Geotemporospatial Study, Albert Stuart Reece, Gary Kenneth Hulse Jun 2022

Epidemiological Association Of Cannabinoid- And Drug- Exposures And Sociodemographic Factors With Limb Reduction Defects Across Usa 1989–2016: A Geotemporospatial Study, Albert Stuart Reece, Gary Kenneth Hulse

Research outputs 2022 to 2026

Background: Reports of major limb defects after prenatal cannabis exposure (PCE) in animals and of human populations in Hawaii, Europe and Australia raise the question of whether the increasing use of cannabis in USA might be spatiotemporally associated with limb reduction rates (LRR) across USA. Methods: Congenital anomaly data was from the National Birth Defects Prevention Network, drug use data was taken from the National Survey of Drug Use and Health (NSDUH), cannabinoid concentration was estimated from Federal seizure data and ethnicity and income data were from the US Census bureau. Geotemporospatial analysis was conducted in R. Results: 436 LRR …

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Enhanced Antioxidant, Antiviral, And Anticancer Activities Of The Extract Of Fermented Egyptian Rice Bran Complexed With Hydroxypropyl-Β-Cyclodextrin, Khaled Nematallah, Sherif Ashraf Fahmy, Noha Khalil Mahdy, Hesham El-Askry, Meselhy Ragab Meselhy, Hassan El-Said Azzazy Jun 2022

Enhanced Antioxidant, Antiviral, And Anticancer Activities Of The Extract Of Fermented Egyptian Rice Bran Complexed With Hydroxypropyl-Β-Cyclodextrin, Khaled Nematallah, Sherif Ashraf Fahmy, Noha Khalil Mahdy, Hesham El-Askry, Meselhy Ragab Meselhy, Hassan El-Said Azzazy

Pharmacy

Egyptian rice bran was fermented with baker’s yeast, and released phenolics were extracted with aqueous methanol to give fermented rice bran extract (FRBE). The analysis of the FRBE with ultra-performance liquid chromatography–electrospray ionization–tandem mass spectrometry revealed 21 compounds, mainly phenolic acids and flavonoids. The FRBE was then complexed with (2-hydroxypropyl)-β-cyclodextrin (HPβCD) via noncovalent host–guest inclusion complexation using the thin-film hydration technique to improve the hydrophilicity and bioactivity of the FRBE. The formation of the inclusion complex was confirmed using HPLC, 1H NMR, FT-IR, and a phase solubility study. In addition, the biological activities of the complex were investigated. The FRBE/HPβCD …

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The Effects Of Dangerous World Beliefs On Covid-19 Preventive Behaviors In Singapore: The Moderating Role Of Public Health Communication, Su Lin Yeo, Desiree Y. Phua, Ying-Yi Hong Jun 2022

The Effects Of Dangerous World Beliefs On Covid-19 Preventive Behaviors In Singapore: The Moderating Role Of Public Health Communication, Su Lin Yeo, Desiree Y. Phua, Ying-Yi Hong

Research Collection Lee Kong Chian School Of Business

This research purposes to examine the role of strategic communication, specifically the effectiveness of government's crisis communication messages at the onset of COVID-19 pandemic in Singapore, on disease preventive behaviors. It employed a mixed method research approach by first carrying out a content analysis of 7128 news headlines on COVID-19 to confirm our presupposition that the media may be communicating messages that the world order is being threatened. Informed by our findings that 90% of news reports were framed to suggest a dangerous world, we surveyed 453 respondents in the main study, and tested if people's beliefs in a dangerous …

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Effects Of A Workplace Exercise Intervention On Cardiometabolic Health: Randomized Controlled Trial, Ali Muneer Al Rahma Jun 2022

Effects Of A Workplace Exercise Intervention On Cardiometabolic Health: Randomized Controlled Trial, Ali Muneer Al Rahma

Dissertations

Brief Introduction: The worldwide rising levels of physical inactivity, especially in the United Arab Emirates (UAE) and the Eastern Mediterranean region, are alarming. The UAE reports one of the highest rates of mortality due to non-communicable diseases, and insufficient physical activity is a major underlying cause. Therefore, action is required to reduce physical inactivity using evidence-based strategies.
/="/">Aims: To evaluate the effect of a 12-week workplace structured exercise intervention on cardiometabolic risk factors and to determine whether the workplace exercise intervention improves physical activity levels four weeks post-intervention.
/="/">Methods: This is a pragmatic parallel, randomized controlled trial with …

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Prevalence Of Lost Time Injuries And Fatalities Among Construction Workers In Al Ain, United Arab Emirates (Uae), Ghuwaya Humaid Alnuaimi Jun 2022

Prevalence Of Lost Time Injuries And Fatalities Among Construction Workers In Al Ain, United Arab Emirates (Uae), Ghuwaya Humaid Alnuaimi

Dissertations

Migrants account for more than 80% of the total population of the United Arab Emirates (UAE). Few population-based data were available about the burden of lost time injuries (LTIs) and fatalities among migrant workers employed in the construction industry. The proposed study aimed to estimate the prevalence of LTIs and associated factors, and fatalities among construction workers in Al Ain, of Abu Dhabi Emirate in the UAE. A cross-sectional study design was used to estimate the prevalence of LTIs resulting in one or more than a day of sick leave in a random sample (n=1,626) of male construction workers in …

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Factors Affecting The Antibacterial Activity Of Cefiderocol On Klebsiella Pneumoniae With Diverse Characteristics, Lana Jamal Rashed Daoud Jun 2022

Factors Affecting The Antibacterial Activity Of Cefiderocol On Klebsiella Pneumoniae With Diverse Characteristics, Lana Jamal Rashed Daoud

Theses

Antimicrobial resistance (AMR) is a growing serious threat that poses a burden on the healthcare system. Spread of AMR bacteria limits treatment options; thus, new antimicrobial agents are required. Cefiderocol (CFDC) is a novel siderophore cephalosporin, approved by the FDA in 2019 for use in treating infections caused by multi-drug resistant (MDR) pathogens; but it is not yet in clinical use in the UAE. CFDC is equipped with stabilizers against β-lactamases as well as a siderophore side chain that allows it to penetrate the outer membrane of bacteria through the iron uptake pathways. The aim of this study is to …

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Post Covid-19 Vaccine Guillain Barre Syndrome, Soban Khan, Maryam Khalil, Zaid Waqar, Sajid Khan, Zakir Jan Jun 2022

Post Covid-19 Vaccine Guillain Barre Syndrome, Soban Khan, Maryam Khalil, Zaid Waqar, Sajid Khan, Zakir Jan

Pakistan Journal of Neurological Sciences (PJNS)

The Guillain Barre Syndrome (GBS) is an acute immune-mediated progressive polyneuropathy having an acute monophasic illness leading to paralysis. The clinical features are progressive ascending symmetrical muscle weakness that may lead to respiratory failure. Diagnosis is based upon clinical presentation and is supported by a lumbar puncture with CSF analysis demonstrating albumin-cytological dissociation, and electrophysiological studies. Our patient presented to us with progressive ascending paralysis after receiving COVID 19 vaccine.

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Churg Strauss Syndrome With Neuropathy: A Case Report, Zaid Waqar Jun 2022

Churg Strauss Syndrome With Neuropathy: A Case Report, Zaid Waqar

Pakistan Journal of Neurological Sciences (PJNS)

A 24 years old man with known history of asthma came with acute presentation of ascending weakness for four days following flu like symptoms and worsening of asthma. His complete blood counts showed elevated eosinophil count. Nerve conduction showed neuropathy. He was diagnosed as Churg Strauss syndrome due to presence of asthma, eosinophilia, neuropathy and pulmonary infiltrates. Churg Strauss is a systemic eosinophilic vasculitis involving multiple organ systems that may present with neuropathy, as in this case.

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Succinic Semialdehyde Dehydrogenase Deficiency – A Rare Cause Of Metabolic Stroke, Areeba Wasim, Javeria Raza Alvi, Tipu Sultan Jun 2022

Succinic Semialdehyde Dehydrogenase Deficiency – A Rare Cause Of Metabolic Stroke, Areeba Wasim, Javeria Raza Alvi, Tipu Sultan

Pakistan Journal of Neurological Sciences (PJNS)

Succinic semialdehyde dehydrogenase (SSADH) deficiency is a rare neurometabolic disorder characterized by defective degradation of gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter of the brain. Children with SSADH deficiency present with motor and mental delay, intractable seizures, infantile onset hypotonia, speech disturbances, extrapyramidal symptoms and ataxia. This wide spectrum results from increased accumulation of 4hydroxy butyric acid (4HBA) leading to down regulation of GABA receptors, which likely explain epileptogenesis but the pathophysiology of stroke in SSADH deficiency is not much elucidated. Here, we report an infant aged 11 months, product of consanguineous marriage with significant family history of motor delay …

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Post Covid-19 Vaccine (Sinovac) Cerebral Venous Sinus Thrombosis, Soban Khan, Maryam Khalil, Zaid Waqar Jun 2022

Post Covid-19 Vaccine (Sinovac) Cerebral Venous Sinus Thrombosis, Soban Khan, Maryam Khalil, Zaid Waqar

Pakistan Journal of Neurological Sciences (PJNS)

SINOVAC is an inactivated virus COVID 19 vaccine given emergency authorization for COVID-19 Pandemic. Different adverse reactions have been seen in after-marketing of COVID-19 vaccines. Here we present a case of patient who developed cerebral venous sinus thrombosis two weeks after the first dose of SINOVAC vaccine.

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Risk Factors Of Intracerebral Hemorrhage – A Cross Sectional Study, Mir Jalal-Ud-Din, Raheel Jehangir Jadoon, Syed Affan Ali, Samia Wazir Khawaja, Zahid Gul Jadoon, Ibtisam . Jun 2022

Risk Factors Of Intracerebral Hemorrhage – A Cross Sectional Study, Mir Jalal-Ud-Din, Raheel Jehangir Jadoon, Syed Affan Ali, Samia Wazir Khawaja, Zahid Gul Jadoon, Ibtisam .

Pakistan Journal of Neurological Sciences (PJNS)

ABSTRACT Background and Objective: Stroke is the major cause of disability and one of the top causes of death in the globe. Though the rate is decreasing in the West, it is most likely growing in Asia. In Pakistan, the burden of stroke risk factors is substantial. Although data on the incidence and prevalence of stroke in Pakistan is limited, there are several published case studies demonstrating major disparities in stroke epidemiology, risk factors, kinds, and patterns. This study aims to identify risk factors of intracerebral hemorrhage among patients presenting to a teaching hospital. Methods: From August 2019 to February …

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Prevalence Of Depression In Caregivers Of Stroke Patients In Karachi, Pakistan, Marium Mansoor, Shahina Pirani, Rabeeka Aftab, Tania Nadeem Jun 2022

Prevalence Of Depression In Caregivers Of Stroke Patients In Karachi, Pakistan, Marium Mansoor, Shahina Pirani, Rabeeka Aftab, Tania Nadeem

Pakistan Journal of Neurological Sciences (PJNS)

ABSTRACT Background and Objective: Caregivers of patients with chronic debilitating illnesses are at risk of developing mental health problems. The objective of this study is to determine the frequency of depression in caregivers of stroke patients at a tertiary care teaching hospital in Karachi, Pakistan. Methods: A cross-sectional study was conducted among caregivers of stroke, who were recruited from the Aga Khan University Hospital between January 2018 to October 2018. Data was collected through the Urdu Hamilton rating scale for depression (HAM-D-U) and it was analyzed using descriptive and inferential statistics. Results: A total of 136 caregivers participated in the …

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Iranian Stroke Model-How To Involve Health Policymakers, Mehdi Farhoudi, Ehsan Sharifipour Jun 2022

Iranian Stroke Model-How To Involve Health Policymakers, Mehdi Farhoudi, Ehsan Sharifipour

Pakistan Journal of Neurological Sciences (PJNS)

Stroke in Iran, with more than 83 million population, is a leading cause of disability and mortality in adults. Stroke has higher incidence in Iran comparing the global situation and unfortunately the onset age of first ever stroke is dropping about 10 years.1 Intravenous thrombolysis, as an approved treatment in ischemic stroke, has been used only in some university or private hospitals in Iran since 2008.2 The main limit for this therapy in Iran was the lack of coverage by health insurance companies for tPA. A project for situation analysis of stroke cases entering to Imam Reza Hospital, a tertiary …

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Practical Measures For Disabled’S Empowerment-Time For Economic Growth!, Mahnoor Hafeez Jun 2022

Practical Measures For Disabled’S Empowerment-Time For Economic Growth!, Mahnoor Hafeez

Pakistan Journal of Neurological Sciences (PJNS)

The objective of this article is to advocate for persons with disabilities’ (PWD) rights, to discuss issues solutions, social awareness and to promote diversity and inclusion. The word ‘Disability’ covers a wide range of irreversible permanent impairments including physical and mobility difficulties, hearing, visual impairment, specific learning disabilities including dyslexia, medical conditions and mental health problems that may hinder their full and effective participation in society on an equal basis with others.1 Handicap is the condition of being unable to perform due to physical or mental unfitness.

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