Medicine and Health Sciences Commons^™

A Case Of A Nonpetrous Cholesterol Granuloma Presenting As A Temporal Mass, Nathaniel Reeve, Jacob Kahane, Matthew Ng

School of Medicine Faculty Research

Objective. A case of a skull base cholesterol granuloma (CG) of the squamosal temporal bone. This is the first ever reported case of CG in a well-pneumatized squamous temporal bone. Design. Case report and review of the literature. Discussion. CG is a cystic mass typically found in the petrous apex and occasionally in the paranasal sinuses and orbit. Experience with the treatment of these expansile and inflammatory processes has largely been garnered from those occurring in the petrous apex, where they are surgically drained, via a transtympanic, transmastoid, or middle fossa approach. We report a case of cholesterol granuloma situated …

Contrast-Enhanced Ultrasound In Association With Serum Biomarkers For Differentiating Combined Hepatocellular-Cholangiocarcinoma From Hepatocellular Carcinoma And Intrahepatic Cholangiocarcinoma., Jie Yang, Ya-Han Zhang, Jia-Wu Li, Ying-Yu Shi, Jia-Yan Huang, Yan Luo, Ji-Bin Liu, Qiang Lu

Department of Radiology Faculty Papers

BACKGROUND: Combined hepatocellular-cholangiocarcinoma (CHC) is a rare type of primary liver cancer. Due to its complex histopathological characteristics, the imaging features of CHC can overlap with those of hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC).

AIM: To investigate the possibility and efficacy of differentiating CHC from HCC and ICC by using contrast-enhanced ultrasound (CEUS) Liver Imaging Reporting and Data System (LI-RADS) and tumor biomarkers.

METHODS: Between January 2016 and December 2019, patients with histologically confirmed CHC, ICC and HCC with chronic liver disease were enrolled. The diagnostic formula for CHC was as follows: (1) LR-5 or LR-M with elevated alpha-fetoprotein …

Association Between Vitamin D Supplementation And Mortality In Critically Ill Patients: A Systematic Review And Meta-Analysis Of Randomized Clinical Trials., Liyuan Peng, Linjie Li, Peng Wang, Weelic Chong, Yin Li, Xi Zha, Haidong Deng, Huaqian Fan, Yu Zhang

Student Papers, Posters & Projects

BACKGROUND: Observational studies suggest that low 25-hydroxyvitamin D status is common and has been associated with higher mortality in critically ill patients. This study aim to investigate whether vitamin D supplementation is associated with lower mortality in critically ill patients.

METHOD: We searched Medline, Embase, and Cochrane databases from inception to January 12, 2020, without language restrictions, for randomized controlled trials comparing the effect of vitamin D supplementation with placebo in critically ill patients. Two authors independently performed data extraction and assessed study quality. The primary outcome was all-cause mortality at the longest follow-up.

RESULT: We identified nine trials with …

Conversational Ontology Operator: Patient-Centric Vaccine Dialogue Management Engine For Spoken Conversational Agents, Muhammad Amith, Rebecca Z Lin, Licong Cui, Dennis Wang, Anna Zhu, Grace Xiong, Hua Xu, Kirk Roberts, Cui Tao

2020-Current year OA Pubs

BACKGROUND: Previously, we introduced our Patient Health Information Dialogue Ontology (PHIDO) that manages the dialogue and contextual information of the session between an agent and a health consumer. In this study, we take the next step and introduce the Conversational Ontology Operator (COO), the software engine harnessing PHIDO. We also developed a question-answering subsystem called Frankenstein Ontology Question-Answering for User-centric Systems (FOQUS) to support the dialogue interaction.

METHODS: We tested both the dialogue engine and the question-answering system using application-based competency questions and questions furnished from our previous Wizard of OZ simulation trials.

RESULTS: Our results revealed that the dialogue …

Week Of December 14, 2020, New York Medical College

InTouch

• Leader in Academic Medicine, Catherine D. DeAngelis, M.D., M.P.H., Is Tapped to Address the Class of 2021
• NYMC Unveils Pandemic Perspectives
• D.P.T. Class of 2022 Community Service Projects Adapt to the Virtual World
• 17th Annual Louis R.M. DelGuercio Research Day to Take Place Virtually on December 16
• HSL Annual Faculty Author Awards Set for December 17

Toll-Like Receptor 7 Is Required For Lacrimal Gland Autoimmunity And Type 1 Diabetes Development In Male Nonobese Diabetic Mice., Ivy L Debreceni, Michael S Chimenti, David V. Serreze, Aron M Geurts, Yi-Guang Chen, Scott M Lieberman

Faculty Research 2020

Sjögren syndrome (SS) is an immunologically complex, chronic autoimmune disease targeting lacrimal and salivary glands. Nonobese diabetic (NOD) mice spontaneously develop inflammation of lacrimal and salivary glands with histopathological features similar to SS in humans including focal lymphocytic infiltrates in the affected glands. The innate immune signals driving lymphocytic infiltration of these glands are not well-defined. Here we evaluate the role of Toll-like receptor (TLR) 7 in the development of SS-like manifestations in NOD mice. We created a Tlr7 knockout NOD mouse strain and performed histological and gene expression studies to characterize the effects of TLR7 on autoimmunity development. TLR7 …

2020-12-13_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

Possible Transmission Flow Of Sars-Cov-2 Based On Ace2 Features, Sk Sarif Hassan, Shinjini Ghosh, Diksha Attrish, Pabitra Pal Choudhury, Alaa A A Aljabali, Bruce D Uhal, Kenneth Lundstrom, Nima Rezaei, Vladimir N Uversky, Murat Seyran, Damiano Pizzol, Parise Adadi, Antonio Soares, Tarek Mohamed Abd El-Aziz, Ramesh Kandimalla, Murtaza M Tambuwala, Gajendra Kumar Azad, Samendra P Sherchan, Wagner Baetas-Da-Cruz, Kazuo Takayama, Ángel Serrano-Aroca, Gaurav Chauhan, Giorgio Palu, Adam M Brufsky

All publications

Angiotensin-converting enzyme 2 (ACE2) is the cellular receptor for the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) that is engendering the severe coronavirus disease 2019 (COVID-19) pandemic. The spike (S) protein receptor-binding domain (RBD) of SARS-CoV-2 binds to the three sub-domains viz. amino acids (aa) 22-42, aa 79-84, and aa 330-393 of ACE2 on human cells to initiate entry. It was reported earlier that the receptor utilization capacity of ACE2 proteins from different species, such as cats, chimpanzees, dogs, and cattle, are different. A comprehensive analysis of ACE2 receptors of nineteen species was carried out in this study, and the …

Coal Energy And Environmental Impacts: Introduction, Luis F. O. Silva, Amy L. Wolfe

Faculty, Staff, and Affiliated Publications--KGS

No abstract provided.

Granulomatosis With Polyangiitis In A Pediatric Male, Florentino Saenz Rios, Sandhya Devaraj, Giri Movva, Hari Movva, Quan D. Nguyen

School of Medicine Publications

Significant eosinophilia is a prominent feature in Churg-Strauss syndrome but has not been described in granulomatosis with polyangiitis (GPA) in a pediatric patient. We present a biopsy case that confirmed granulomatosis with polyangiitis with significant eosinophilia > 30% on the initial presentation. Etiologies that could account for eosinophilia were excluded during workup. The patient's presentation of pulmonary alveolar hemorrhage, conjunctivitis arthritis, high-titer cytoplasmic antineutrophil, PR3-ANCA antibodies, and cytoplasmic antibodies (cANCA) was consistent with a clinical picture of atypical GPA in a pediatric patient. This case presents a rare opportunity not only due to GPA’s low incidence in the pediatric population but …

Role Of Nutraceuticals In Covid-19 Mediated Liver Dysfunction, Mohammed Sikander, Shabnam Malik, Anyssa Rodriguez, Murali M. Yallapu, Acharan S. Narula, Sanjaya K. Satapathy, Vijian Dhevan, Subhash C. Chauhan, Meena Jaggi

School of Medicine Publications

COVID-19 is known as one of the deadliest pandemics of the century. The rapid spread of this deadly virus at incredible speed has stunned the planet and poses a challenge to global scientific and medical communities. Patients with COVID-19 are at an increased risk of co-morbidities associated with liver dysfunction and injury. Moreover, hepatotoxicity induced by antiviral therapy is gaining importance and is an area of great concern. Currently, alternatives therapies are being sought to mitigate hepatic damage, and there has been growing interest in the research on bioactive phytochemical agents (nutraceuticals) due to their versatility in health benefits reported …

Mexican Americans' Perspectives On "Borderline Diabetes" In Amarillo, Texas, Priscella Pena-Correa

Nursing ETDs

The purpose of this study was to explore the meaning of and experiences living with “borderline diabetes” among Mexican American adults residing in or around Amarillo, Texas. Sixteen Mexican Americans who self-identified as having “borderline diabetes” participated. Research questions focused on how participants understood the condition, self-care practices, and recommendations for improving prediabetes healthcare and education. An interpretive description approach was used to analyze data from phone interviews. Principal findings revolved around issues of disclosure vs. secrecy, information seeking, and challenges or “struggle” to change lifestyle, particularly diet. Self-care was managed in a relational way with support of family, friends, …

Bibliometric Survey On Effect Of Climate Factors On Spread Of Coronavirus (Covid-19), Seema Patil, Jay Makwana, Manish Attri

Library Philosophy and Practice (e-journal)

The new SARS-CoV-2 COVID-19 has spread quickly around the globe since it was first reported in Wuhan city of China, in December 2019 subsequent to being contracted from a zoonotic source. The main focus of this bibliometric survey is to recognize the few studies which have upheld the epidemiological hypothesis that the effect of climatic factors is playing a crucial role in the spreading of COVID-19. The analysis is done on the basis of 412 documents such as journals, articles, editorials, short surveys and some review papers. The United States contributes to the maximum number of publications followed by the …

Mindful Mind Project, Toussaint Campbell

Capstones

Mindfulness includes the methods one takes to care for themselves by acknowledging and accepting one’s feelings, thoughts, and bodily sensations while conducting daily tasks. Mindfulness can manifest in unique actions and activities depending on an individual's needs. However, many lack education on mental health resources as well as access to the tolls that could be beneficial to them. This collection of opinion pieces takes a look at themes in a society where mindfulness can be incorporated and how practices can impact communities of color.

Link to capstone: https://mindfulmindproject.com/

A Stroke Of Misfortune, Madison Ruffo

Capstones

In May 2019 my great grandmother, Carmel Ruffo, went to the hospital for a bowel impaction. One month and one stroke later she died. Since then, my great uncle–her son–has worked tirelessly seeking answers about the nature of his mother’s death. But the healthcare industry is a labyrinth of mind-boggling jargon, complex policies, and too-often dead ends.

In this story, the reader follows my uncle and me, just one of the hundreds of thousands of grieving families who suspect medical error contributed to their loved one’s death, as we navigate the bureaucracy of New York’s healthcare system and dig for …

Improving Nurse Engagement Through Unit Practice Councils: A Literature Review, Pavna Sloan

Doctor of Nursing Practice (DNP) Projects

Problem: According to The Advisory Board Company, nurses are the least engaged group of healthcare employees (The Advisory Board Company, 2014). This finding concerns healthcare organizations because those with a high percentage of disengaged nurses have increased nurse turnover rates and decreased patient satisfaction and safety scores (Kutney-Lee et al., 2016). Shared governance, in the form of the Unit Practice Councils (UPC), is a model healthcare organizations implement to increase nurse engagement. A review of the current literature is needed to evaluate if the model is effective.

Purpose: The purpose of this article is to provide a comprehensive literature …

2020-12-12_Michigandaily_Covidmap, Michigan Department Of Health & Human Services

Daily Michigan COVID-19 Update

The "WHERE WE STAND WITH COVID-19" map was obtained from Michigan's main COVID-19 page: https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily at 3p.m., Monday - Saturday.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled.

The image contained a map, indicating total cases by county, and also provides statistics on Total Confirmed Cases, Total COVID-19 Deaths, Daily Confirmed Cases, and Daily COVID-19 Deaths. There …

2020-12-12_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services

Cumulative Michigan COVID-19 Data

The COVID Overview page was obtained from Michigan's main COVID-19 page: https:/www.michigan.gov/coronavirus/0,9753,7-406-98163-520743--,00.html.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled. It is updated Monday - Saturday.
This report is provisional and subject to change. City of Detroit and Wayne County are reported separately. MDHHS began tracking probable cases April 5, 2020. FCI indicates federal correctional institute. MDOC indicates Michigan Department of Corrections. Diagnostic tests, including nucleic acid amplification/real-time polymerase chain reaction (NAAT/RT-PCR) and rapid virus antigen detection point of …

2020-12-12_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

Prenatal Alcohol Exposure Alters Transcriptional Expression Of Stress And Tlr4-Related Immune Signaling Factors In The Brain Following Early Life Stress, Chaselyn D. Ruffaner-Hanson

Biomedical Sciences ETDs

Background: Depression and anxiety disorders, believed to be caused by stress-related neuropeptides and pro-inflammatory molecules in the brain, are prevalent comorbidities of fetal alcohol spectrum disorders (FASD).

Methods: Brain tissue was collected following a 4-hour maternal separation stress during the early postnatal period, postnatal days 10 and 12, from mice subjected to 1^st and 2^nd trimester prenatal alcohol exposure (PAE).

Hypothesis: We hypothesized that PAE leads to glucocorticoid receptor insensitivity, stress molecule overexpression, and potentiated toll-like receptor 4 (TLR4) pathway inflammatory responses in the brain following early life stress.

Results: PAE and stress increased mRNA expression of TLR4 …

Adult Hippocampal Neurogenesis As A Potential Therapeutic Target In Fetal Alcohol Spectrum Disorders, Kymberly Cheyanne Gustus

Biomedical Sciences ETDs

This dissertation aims to determine if adult hippocampal neurogenesis is a potential therapeutic target in Fetal Alcohol Spectrum Disorders (FASDs). Adult hippocampal neurogenesis plays important and unique roles in certain aspects of learning, memory, and mood (Anacker & Hen, 2017). Individuals with FASDs often demonstrate dysregulation in these arenas (Lewis et al., 2015; Temple, Cook, Unsworth, Rajani, & Mela, 2019). Previous work in our lab using a mouse model of prenatal alcohol exposure demonstrated impairment in enrichment-mediated adult hippocampal neurogenesis (Irene Y. Choi, Andrea M. Allan, & Lee Anna Cunningham, 2005; K. Kajimoto, A. Allan, & L. A. Cunningham, 2013). …

Improving Clinical Communication And Collaboration Through Technology, Michelle Machon

Doctor of Nursing Practice (DNP) Projects

Problem: Over the last 30 years, clinical communication methodologies in healthcare have evolved to become such disparate systems that they lead to confusion, wasted time, and clinician dissatisfaction. The Joint Commission (2016) reports up to 78% of sentinel events in hospitals are linked to communication failures, which have obvious implications for hospital systems in the quality and safety of their current communication systems.

Context: The purpose of this project was to determine the effectiveness of implementing a unified clinical communication technology platform in an acute care hospital setting and to make recommendations from that implementation to the organization’s larger health …

When Duty Calls. A Faith & Health Collaborative Response To Covid 19 And Social Justice: A Commentary, Joe Bohn, Karen Liller

Florida Public Health Review

We provide information pertaining to an interdisciplinary collaboration in West Central Florida that launched a faith & wellness teleconference intervention in March 2020 in response to the COVID-19 crisis. The collaborative partners engaged from across the 4-county region upon community lockdowns in response to the COVID-19 crisis and later addressing calls for social justice due to the deaths of George Floyd and other African Americans. For 17-weeks Christian and Muslim faith leaders provided live messages of hope along with community partners providing wellness (mental health and wellbeing) focused strategies for coping with the crisis. Thematic analysis of anecdoctal comments revealed …

Role Of The Acid Sensing Ion Channel 1a In The Systemic Circulation, Selina M. Garcia

Biomedical Sciences ETDs

Acid-sensing ion channel 1a (ASIC1a) is a non-selective cation channel that is expressed in vascular smooth muscle cells. However, little is known about the contribution of ASIC1a to vascular reactivity and cardiovascular homeostasis. We have previously shown that ASIC1a contributes to pulmonary vascular smooth muscle cell (VSMC) Ca²⁺ entry and vasoconstriction as well as chronic hypoxia-induced pulmonary hypertension. However, a role of ASIC1a in the systemic circulation is unclear. Previous reports have shown that ASIC1a is expressed in femoral and cerebral arteries, however, these studies suggest that ASIC1a contributes to vascular reactivity through neuronal regulation rather than vascular. Therefore, …

Hepatitis C Virus Care Cascade In Persons Experiencing Homelessness In The United States In The Era Of Direct-Acting Antiviral Agents: A Scoping Review, Aubrey Del Rosario

Biomedical Sciences ETDs

Background: The Hepatitis C Virus (HCV) care cascade has been well characterized in the general United States population and other subpopulations. However, information is limited on care cascade outcomes in persons experiencing homelessness now that highly effective medications offer the potential for cure.

Objectives: The main objective of this study is to map the available evidence on HCV care cascade outcomes in homeless and marginally housed cohorts in the United States in the era of direct-acting antiviral agents. Primary and secondary outcomes of interest include linkage to care and sustained virologic response. Exploratory outcomes include other care cascade …

The Role Of Anti-Inflammatory Cytokine Interleukin-10 (Il-10) In Tauopathies, Lea L. Weston

Biomedical Sciences ETDs

Tauopathies are neurodegenerative diseases, including Alzheimer’s disease, that are associated with pathological accumulation of the microtubule associated protein tau (MAPT, or tau) (Lee et al., 2001). Abnormal hyperphosphorylated tau (pTau) strongly correlate with cognitive impairment (Nelson et al., 2012). Neuroinflammation is also associated with tauopathies (Gerhard et al., 2006b; Edison et al., 2008) and is implicated in driving tau pathology (Yoshiyama et al., 2007, Maphis et al., 2015b). Therefore, it is compelling to understand the role of anti-inflammatory cytokines in limiting neuroinflammation and tau pathology. Interleukin-10 (IL-10) is a well-established anti-inflammatory cytokine with roles in limiting inflammation in the central …

Implementing Simulation In Icu New Graduate Nursing Orientation: Introducing Two Practice Innovations, Aiza Quinday Msn

Master's Projects and Capstones

A change project involving the use of innovative wearable simulation technology was integrated into the 12-week new graduate nurse ICU training program at one community hospital in Northern California. Project implementation was interrupted by the Covid-19 pandemic, so only the first pilot training session was conducted. Initial results from this training session suggest that the simulation training had a positive impact on the nurses’ ability to assess patient breath sounds and to recognize and treat a rapidly deteriorating patient. This training session also allowed the project team to identify additional areas of skill assessment and opportunities for improvement for the …

Reducing Hospital Acquired Pressure Injuries Through A Standardized Prevention Bundle, Austin Lee Stoker

Master's Projects and Capstones

Abstract PROBLEM: Currently healthcare acquired pressure injuries (HAPIs) in the United States result in significant and unnecessary costs along with lost revenue for healthcare facilities. These costs are estimated to be between 9.1 and 11.6 billion dollars annually. Pressure Injuries (PIs) are directly associated with decreases in patient outcomes and are deemed preventable incidents. HAPI prevention can mitigate this clinical and financial problem for patients and organizations. CONTEXT: Unnecessary patient harm related to four HAPI occurrences in the last quarter on the 2B Medical Surgical Telemetry Unit in an integrated managed care delivery system continue to be of concern. Adherence …

Bibliometric Survey On Effects Of Climate Change On Incidences Of Infectious Diseases, Seema Harshad Patil, Yatharth Jain, Vedant Marathe

Library Philosophy and Practice (e-journal)

^{For understanding the influx of Infectious Diseases, research of climate change and its effects pertaining to the diseases is important. The motive of this bibliometric survey is to understand the research which has been carried out regarding the aforementioned topics. This paper summarizes the research in the 21st Century from 2001 to present. We conducted this analysis using tools such as Gephi, Researchgate, Scopus, ScienceScape, Google Scholar and Mapchart. This Bibliometric Survey on “Effects of Climate Change on Infectious Diseases” showed that maximum publications are articles. These publications are from conferences and journals related to Environmental Science. The United States …}

Transversus Abdominis Plane Block As A Sole Anesthetic Technique For Open Appendectomy In Patient With Treacher Collins Syndrome: A Case Report, Khalid Maudood Siddiqui, Muhammad Asghar Ali, Bushra Salim

Department of Anaesthesia

Patients with Treacher Collins syndrome (TCS) present serious challenges to anesthetist in securing of airway; upper airway obstruction and difficult tracheal intubation are considered complex entity in these patients. This case report describes the significance of transversus abdominis plane (TAP) block as a sole anesthetic choice in appendectomy where airway management can be avoided. A 17-year-old boy, known case of TCS, presented with acute appendicitis underwent emergency laparotomy. Surgery was successfully performed by TAP block with dexmedetomidine infusion. Open appendectomy can be performed successfully in certain circumstances under TAP block with adjunctive use of dexmedetomidine infusion where airway handling is …