Medicine and Health Sciences Commons^™

Immunologic Analysis Of Non-Small Cell Lung Cancer In People Living With Hiv, Ramsey Yusuf

Yale Medicine Thesis Digital Library

Among people living with HIV (PLWH), non-small cell lung cancer (NSCLC) has emerged as the most common non-AIDS defining cancer and a leading cause of death. PLWH with NSCLC are diagnosed at younger ages and demonstrate worse outcomes compared to the general population. Global immune dysregulation in the setting of HIV infection may account for these disparities, however little is known about the immunobiology of HIV-associated NSCLC. The goal of this study was to investigate the clinical and pathology of NSCLC in PLWH. This retrospective cohort study examined HIV-associated and uninfected NSCLC cases within Yale-New Haven Hospital between 2000-2016. Medical …

Mechanisms Of Pathogen Inactivation In Wastewater And Pharmaceutical Applications, Christa L. Meingast

Dissertations, Master's Theses and Master's Reports

Infectious diseases are a significant threat to public health. Though society enacts practices to prevent the spread of these dangerous diseases, challenges remain. Therefore, continual advancements in treatment and prevention are required. Wastewater treatment and viral clearance in pharmaceutical applications are two key health measures that prevent the spread of infections.

A low-cost, low-technology biosolids treatment process was developed to improve wastewater treatment by collecting key information on storage temperature, ammonia, volatile solids, moisture content, pH, and pathogen inactivation in biosolids over long-term storage at two wastewater treatment plants located in northern climates of the United States. Inactivation of pathogens …

The Evolving Pharmacotherapeutic Landscape For The Treatment Of Sickle Cell Disease., Samir K Ballas

Cardeza Foundation for Hematologic Research

Sickle cell disease (SCD) is an extremely heterogeneous disease that has been associated with global morbidity and early mortality. More effective and inexpensive therapies are needed. During the last five years, the landscape of the pharmacotherapy of SCD has changed dramatically. Currently, 54 drugs have been used or under consideration to use for the treatment of SCD. These fall into 3 categories: the first category includes the four drugs (Hydroxyurea, L-Glutamine, Crizanlizumab tmca and Voxelotor) that have been approved by the United States Food and Drug Administration (FDA) based on successful clinical trials. The second category includes 22 drugs that …

The Issue Of Skeletal Muscle Growth And Regeneration, Ayman Ghallab, Ayman Mohammed Ghallab

Dentistry

The aim of our criticism of the paper authored by Makovický and Makovický (2020) was to prevent the readers from being misinformed by a paper based on a major flaw such as confusing splitting muscle fibers with a stretch receptor.

Hyper-Sensitivity Assessment After Immediate Versus Delayed Dentine Sealing In Indirect Composite Restorations: Randomized Controlled Clinical Trial, Hoda Fouda

Dentistry

Aim: to evaluate the efficacy of immediate dentin sealing using universal adhesive in comparison to delayed dentin sealing in the reduction of the hypersensitivity in teeth prepared for indirect tooth composite restorations using Visual Analog Scale (VAS). Materials and methods: Fifty-four patients between 18 and 30 years of age were recruited and randomized to the treatment protocols. After baseline preoperative data collection, diagnosis of caries was done depending on the basis of clinical examination that was done tentatively and radiographic examination was done as well. After cavity preparation was done, for the cavities to be managed with immediate dentine sealing, …

Comparative Study Of Two Fifferent Telescopic Crown Materials Retaining Lower Partial Overdenture, Fardos N. Rizk Prof., Ayman Hany Amin Dr., Gehan Fikry Prof., Amr Ismail Dr.

Dentistry

Background and Objective: This study was conducted to measure the difference between Chrome Cobalt telescopic crowns and Poly ether ether ketone (PEEK) telescopic crowns retaining implant retained partial overdenture.

Materials and Methods: This is a comparitive study that included fourteen lower kennedy class I partially edendulous patients. All patients received posterior implant in the second molar area in each side. The patients were divided into 2 groups, the first group received chrome cobalt telescopic crown and the second group received poly ether ketone telescopic crowns over the implants. Partial overdenture was constructed for all the patients in the two groups. …

The Effect Of Smoking On Clinical Presentation And Expression Of Tlr-2 And Cd34 In Oral Lichen Planus Patients: Clinical And Immunohistochemical Study, Enji Ahmed Mahmoud, Nermin Yousif, Nermin Raouf

Dentistry

Background: Oral lichen planus is a chronic inflammatory disease which is considered as a potential precancerous condition. Numerous studies have confirmed that inflammation is a strong risk factor for cancer development. Smoking is associated with potentially malignant disorders of the oral and oropharyngeal mucosa. The adverse consequences of smoking in various pathologies are mediated by its effects on the immune-inflammatory system. Little is known about the influence of cigarette smoke content on the course of OLP and inflammatory response. Methods: Twenty oral lichen planus smoker patients, 20 oral lichen planus non-smoker patients and 20 control patients were included in this …

Radiographic Evaluation Of Bone And Mucosa Using Low-Dose Cbct With Radiopaque X-Resin Stent Versus Ct And Ridge Mapping: A Validity Study, Enji Ahmed Mahmoud, Nader Nabil Rizkallah, Eman Abdelaziz, Mushira Mohamed Dahaba

Dentistry

No abstract provided.

Co-Occurrence Across Time And Space Of Drug- And Cannabinoid- Exposure And Adverse Mental Health Outcomes In The National Survey Of Drug Use And Health Dataset 2: Combined Ecological Geotemporospatial And Causal Inference Analysis [Dataset], Albert Stuart Reece

Research Datasets

Background: Whilst many studies have linked increased drug and cannabis exposure to adverse mental health (MH) outcomes their effects on whole populations and geotemporospatial relationships are not well understood.

Objectives: Determine: (1) if cannabis use is associated with major MH outcomes ascross space and time, (2) if such impacts are robust to multivariable adjustment and (3) if the relationship is causal.

Methods. Ecological cohort study of National Survey of Drug Use and Health (NSDUH) geographically-linked substate-shapefiles 2010-2012 and 2014-2016 supplemented by five-year US American Community Survey. Drugs: cigarettes, alcohol abuse, last-month cannabis use and last-year cocaine use. MH: any mental …

Augmenting Public Health Informatics Capacity To Better Manage Covid-19, Pascal Felix, Gulzar H. Shah

Eagles Talking About the Public’s Health

No abstract provided.

Association Between Participation In Annual Physical Examinations And Risk Factors For Noncommunicable Diseases In Adults With Disabilities: Evidence From Shanghai, China, Yugang Li, Qi Zhang, Xiaohong Li, Mei Sun, Jun Lu, Gang Chen

Community & Environmental Health Faculty Publications

The relationships between regular participation in annual physical examinations and the risk factors for noncommunicable diseases (NCDs) among adults with disabilities remains unclear. To address this gap, we used data from 130,899 individuals with disabilities in Shanghai (2014-2016) and evaluated four risk factors for NCDs: hypertension, hyperglycemia, hyperlipidemia, and being overweight. Overall, 4540 individuals participated in annual physical examinations across all three years and 11,388 missed examinations in 2015 (group without regular participation). Chi-squared tests and binary logistic regression were used to assess differences in patient characteristics and explore correlations between variables. Significant differences in age (χ² = 102.620, …

Factors Associated With Tobacco Smoking Among Saudi College Students: A Systematic Review, Saad A. Alotaibi, Praveen K. Durgampudi

Community & Environmental Health Faculty Publications

INTRODUCTION There has been an increase in tobacco smoking among Saudi college students in recent years. However, no study has examined, with a systematic approach, the extent to which specific factors are associated with tobacco smoking among this population.

METHODS PubMed, ProQuest, CINAHL, and Web of Science were utilized to retrieve studies addressing risk factors associated with tobacco smoking among Saudi college students between 2010 and 2019. After confirming their eligibility criteria, studies were imported to the NVivo software for data collection and synthesis. All included articles were critically appraised, based on a modified STROBE.

RESULTS Twenty-one out of 300 …

Statistical Analysis Of Fnirs Data: Consideration Of Spatial Varying Coefficient Model Of Prefrontal Cortex Activity Changes During Speech Motor Learning In Apraxia Of Speech, Rachel Johnson, Jennifer Matthews, Norou Diawara, Rachel Carroll

Communication Disorders & Special Education Faculty Publications

Apraxia of speech is an impairment in the planning and programming of speech typically accompanied by aphasia (language impairment) secondary to a left hemisphere stroke. It is unknown if the structural and functional connections to the damaged area implicate the integrity of the cognitive functions of the prefrontal cortex (PFC). The present study examines the feasibility of measuring hemodynamic activity in the PFC in response to the structure of practice and during treatment. This multiple-baseline single case-design study involving two individuals with chronic acquired apraxia of speech measured the hemodynamic changes in PFC activity during treatment across the intervention period …

Reducing Gaps In Knowledge About Electroconvulsive Therapy Among Mental Health Nurses, Janice L. Edmonson

Electronic Theses and Dissertations

This DNP study was conducted to identify knowledge gaps about electroconvulsive therapy (ECT) among mental health nurses and to determine the effectiveness of an educational intervention on the knowledge and attitude of mental health nurses about the use of ECT at a psychiatric hospital. In this study, the researcher sought to build upon an existing knowledge base using principles of adult learning theory to enhance the therapeutic relationship of the nursing staff when caring for ECT patients. A sample of three-quarters (N = 119) of the mental health nursing staff employed by the psychiatric hospital consented to participate in …

Clinical Outcomes Of Orofacial Myofunctional Therapy In Children Without Concurrent Orthodontia, Julia Logan

Graduate Research Papers

Purpose: Orofacial Myofunctional Therapy (OMT) addresses impairments in breathing, swallowing, chewing, and/or speech by eliminating maladaptive oral behaviors (e.g., poor position of the tongue and noxious habits); however, there is little evidence regarding its clinical effectiveness separate from concurrent orthodontia. The present study sought to explore early changes in tongue strength, dentition/palatal shape, and orofacial behaviors following OMT in the absence of orthodontic treatment.

One-Year Changes In Brain Microstructure Differentiate Preclinical Huntington's Disease Stages, Chris Patrick Pflanz, Marina Charquero-Ballester, D S. Majid, Anderson M. Winkler, Emmanuel Vallée, Adam R. Aron, Mark Jenkinson, Gwenaëlle Douaud

School of Medicine Publications and Presentations

OBJECTIVE: To determine whether brain imaging markers of tissue microstructure can detect the effect of disease progression across the preclinical stages of Huntington's disease.

METHODS: Longitudinal microstructural changes in diffusion imaging metrics (mean diffusivity and fractional anisotropy) were investigated in participants with presymptomatic Huntington's disease (N = 35) stratified into three preclinical subgroups according to their estimated time until onset of symptoms, compared with age- and gender-matched healthy controls (N = 19) over a 1y period.

RESULTS: Significant differences were found over the four groups in change of mean diffusivity in the posterior basal ganglia and the splenium of the …

Neurodegenerative Modeling: Tau Protein, Degradative Pathways, And Gene Expression Profiling Of Human Ipsc-Derived Neural Precursors And Differentiated 3-D Neural Sphere Versus 2-D Monolayer Cultures, Kyle H. Anthoney

Cal Poly Humboldt theses and projects

Human induced pluripotent stem cells offer a model for human brain development and disease by differentiation into brain organoids; however, current neural culture systems lack the microenvironment, neuronal circuits and connectivity, vascular circulation, and immune system that exist in vivo. After differentiation and development of neuronal and non-neuronal cell types within two formats of cell cultures, we can visualize and recapitulate in vivo protein accumulation, gene expression, and degradative processes such as autophagy. Using RNA extraction, purification methods and reverse transcription I compared traditional monolayer cultures and novel 3-D neural sphere cultures via gene expression analysis. This analysis indicated …

Training Postural Control With Eyes Closed Vs. Eyes Open And Effects On Postural Control Improvement, Mark D. Ulbricht

Cal Poly Humboldt theses and projects

Introduction: Ankle sprains are one of the more common injuries in an athletic population. Postural control training can be used in prevention and rehabilitation for ankle sprains. When used preventively postural control training can decrease the risk of sustaining an ankle sprain by 38% (McGuine & Keene, 2006). There are a variety of postural control training programs all emphasizing different aspects of postural control, such as eyes closed, or eyes open situations. Training protocols with either eyes closed or eyes open have been shown to improve both static and dynamic postural control (Zech et al., 2010). The purpose of this …

The Pharmacokinetics Of A Novel Anti-Renalase Antibody Used For The Treatment Of Melanoma In A Congenic Mouse Species, Oriyomi Alimi

Yale Medicine Thesis Digital Library

The pharmacokinetics of a humanized anti-RNLS monoclonal antibody used for the treatment of melanoma in a congenic mouse species

Authors: Oriyomi Alimi1, Gary Desir1

1Department of Internal Medicine, Yale School of Medicine, New Haven, CT

Cancer cells can overcome signaling that restrains their growth and promotes senescence and cell death. Renalase (RNLS) is a secreted flavoprotein that functions as a survival factor after ischemic and toxic injury, signaling through the plasma calcium channel PMCA4b to activate the PI3K/AKT and MAPK pathways. In addition, recent studies, indicate that dysregulated RNLS signaling promotes survival of melanoma cells due to its capacity to …

Context Of Injury Among Abusive And Accidental Injuries In Children, Lindsay Eysenbach

Yale Medicine Thesis Digital Library

Child physical abuse is a significant public health challenge with an incidence of approximately 6.4 hospitalized cases per 100,000 children. Many abused children, however, will go undiagnosed by physicians evaluating these injuries. Assessing whether a child has been abused is a high-stakes decision: a missed case leaves a child vulnerable to future injury, but an inaccurate diagnosis of abuse may be greatly disruptive and stigmatizing to children and their families. Previous research has established key physical examination and radiographic findings that are associated with abusive injury. A gap in the literature, however, is the role of additional injury circumstances and …

Human Amniotic Membrane Improves Healing In A Chronic, Massive Rotator Cuff Repair Model, Maarouf Saad

Yale Medicine Thesis Digital Library

Rotator cuff tendon heals by fibrovascular scar that is weaker than native tissue leading to repairs that are prone to failure. To investigate the utility of an amniotic-membrane-derived human allograft in improving tendon-bone healing and skeletal muscle architecture, a rotator cuff repair model in Sprague-Dawley rats was established, tendon biomechanical testing, single muscle fiber biomechanical testing, microcomputed tomography analysis, tendon and muscle histological analysis, and gene expression analysis were performed. Our findings demonstrated single muscle-fibers with larger cross-sectional area and greater maximum isometric and specific force in the augmented experimental repair (ER) group. Additionally, microcomputed tomography revealed a larger volume …

Cardiometabolic Risk Factors Associated With Renal Function In Apparently Healthy Young Students: A Cross-Sectional Study, Lucia M. Perez-Navarro, Rafael Valdez-Ortiz, Araceli Alegria-Diaz, Miguel Murgia-Romero, Rafael Jimenez-Flores, Rafael Villalobos-Molina, Srinivas Mummidi, Ravindranath Duggirala, Juan Carlos Lopez Alvarenga

School of Medicine Publications and Presentations

Background: Cardiometabolic risk factors (CMRFs) appear decades before developing chronic kidney disease (CKD) in adulthood.

Objective: The objective of the study was to identify the prevalence and association between CMRFs and kidney function in apparently healthy young adults (18-25 years old).

Methods: We included 5531 freshman year students. Data collected on CMRFs included central obesity, high body mass index (hBMI >25), blood pressure, glycemia, lipids, uric acid (UA >6.8 mg/dL), and insulin. Glomerular filtration rate (GFR) was estimated by CKD-Epidemiology Collaboration formula. We used logistic regression and a log linear for odds ratio (OR) (95% confidence level) and probabilities.

Results: …

Introducing A Model And A Framework To Unify The Pharmaceutical Quality System Enablers Quality Risk Management & Knowledge Management, Martin J. Lipa, Kevin O'Donnell, Anne Greene

Articles

An organization that effectively manages knowledge should be able to recognize and proactively apply new learnings to better anticipate risks. This is particularly important in the manufacture of medicinal products. Since the publication of ICH Q10 in 2010, Quality Risk Management (QRM) and Knowledge Management (KM) have been positioned as co-enablers to the Pharmaceutical Quality System. The authors of this paper present a Knowledge Management process model to foster greater practical understanding of the practice of knowledge management. This model when joined with the familiar ICH Q9 process model for QRM, should enable a company to better manage their knowledge …

Tick-Borne Infections In New Hampshire: An Evaluation Of The Diagnostic Process In A Local Patient Population, Katherine Anderson

Honors Theses and Capstones

Overall, approximately 95 percent of reported cases of vector-borne disease were associated with ticks, making these the most medically important group of arthropods in the United States.¹ Despite the prevalence of tick-borne infections, the process for the diagnosis of this condition is not well studied. This study aims to analyze data from a pool of 100 patients who underwent testing for tick-borne disease in the same institution in Dover, New Hampshire during the most recent peak tick season of 2019. Information utilized in this study included: patient age, sex, location of testing (inpatient versus outpatient), diagnostic testing methods used …

Changes In Bone Health Of Female College Students, Sarah E. Pogany, Jesse Morrell, Maggie Dylewski Begis, Gretchen Arnold

Honors Theses and Capstones

Objective: Identifying individuals with low bone ultrasound attenuation (BUA) z-scores under the age of 30 can allow for improvements of bone health through increased intake of calcium and vitamin D, physical activity, and avoidance of excessive alcohol or caffeine intake. The goal of this study was to assess changes in bone health and observe related risk factors among female college students.

Participants and Methods: Female students (n=38) enrolled in the Nutrition Program at the University of New Hampshire (UNH) who participated in the College Health and Nutrition Assessment Survey (CHANAS) were recruited to participate in a follow-up study …

The Cholera Crisis In Yemen: Case Studies On Vulnerability And Resilience In Sana'a, Al Hudaydah, And Ma'areb, Noor Albannein A. Al-Saad

Honors Theses and Capstones

The largest recorded cholera epidemic in history is happening right now in Yemen, a country which has reported over 2 million cases of cholera as of 2020. Yemen has a history of endemic cholera, but prolonged conflict in the country has led to deteriorating conditions that have triggered massive outbreaks of the disease. The purpose of this study is to investigate the direct and indirect causes of the cholera epidemic in Yemen by proposing factors that may confer vulnerability and resilience in Yemeni governorates. Case studies were constructed for three governorates: Sana’a and the inner municipality of Amanat Al Asimah; …

Mild Traumatic Brain Injuries As A Possible Risk Factor For Anterior Cruciate Ligament Tears In Female High School And College Athletes, Brooke Weyand

Capstone Showcase

Introduction: Both mild traumatic brain injuries (concussions) and anterior cruciate ligament (ACL) tears are among two of the most common, and most career-ending sports medicine injuries. Concussions often result from a blow to the head that can cause headaches, difficulty concentrating, photophobia, and memory loss. Concussion recovery often involved brain rest from athletics, screen exposure, reading, lights, and if severe enough, academics. The ACL is a ligament that is detrimental in stabilization of the knee joint. It connects the femur to the tibia within the joint, and can tear suddenly if it undergoes a quick twisting motion. ACL tears often …

Efficacy Of Curcumin In The Treatment Of Advanced Pancreatic Ductal Adenocarcinoma Compared To Sole Gemcitabine Chemotherapy, Komal Vadodaria

Capstone Showcase

Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer death in both men and women. Due to the difficulty of diagnosing this malignancy until it has progressed to an advanced stage, treatment is often difficult, expensive and ineffective. The first line treatment for PDAC is Gemcitabine chemotherapy. However, due to its extensive side effect profile and the early chemo-resistance the PDAC cells develop against Gemcitabine, the need for alternative therapeutic methods to manage treatment is necessary. Therefore, this review analyzes if in individuals with advanced pancreatic ductal adenocarcinoma [P], does the addition of curcumin with the standard Gemcitabine chemotherapy …

Improving Patient Satisfaction With The Virtual Handoff Process Through The Utilization Of Educational Pamphlets In The Emergency Department, Lynda Michelle Heintz

Doctoral Dissertations and Projects

Boarding patients in the emergency room while waiting to transfer the patient to the proper unit can be harmful to clinical care and have significant financial opportunity costs. At one local hospital it was found that on average patients were being boarded in the emergency room (ED) for approximately 85 minutes waiting to be transferred. Several barriers that caused this delay were found including, delay in room cleaning, nurse staff shortage, and inability to give report to the nurse receiving the patient. In an attempt to combat this delay which may be caused by a difficulty in giving patient report, …

Effect Of The Prospect Of Transport On Captive Tiger Behavior And Fecal Cortisol In Naïve And Experienced Tigers, Callan Lichtenwalter

Graduate Theses and Dissertations

With close to 5,000 captive tigers in the United States, it is vital to ensure that these tigers are receiving adequate welfare whether they are in an accredited facility, or privately owned. The goal of this study was to assess whether captive tigers at a rescue facility with experience being transported outside of the facility would respond differently to the presentation of their transport vehicle than their naïve counterparts who had only been transported within the facility. The behavior of 5 naïve and 7 experienced tigers (n = 12) located at Turpentine Creek Wildlife Refuge in Eureka Springs, Arkansas was …