Medicine and Health Sciences Commons^™

The Perception Of Head Impacts Sustained By Collegiate Baseball Catchers: A Pilot Study, Caleb Johnston

Student Scholar Showcase

Repetitive subconcussive head impacts have been studied in a variety of contact sports and have been found to impair performance in football, soccer, hockey, and lacrosse athletes. To our knowledge no one has investigated the frequency of head impacts in the sport of collegiate baseball. To date, athlete perceived number of head impacts and actual head impacts recorded during participation have not been compared. A sample of 3 baseball catchers from one National Collegiate Athletic Association (NCAA) Division III baseball team were studied.Our results indicated perceived game impacts did not differ from actual game impacts (t₂=1.76, P=.23; …

Functional Movement Patterns And Perceived Mobility In Collegiate Lacrosse Athletes, Christopher J. Rosenborough

Student Scholar Showcase

Context: The stress on the body from sport participation may play a role in an athlete’s ability to function throughout a season. The primary objective of this study was to examine the effects of a non-traditional lacrosse fall season on functional movement patterns for both males and females. Our second objective was to observe how collegiate lacrosse athletes perceived mobility.

Methods: Fifty males (age=19.38+1.24 years, height=182.63+6.16 cm, mass=82.37+8.46 kg) and 22 females (age=19.68+1.17 years, height=165.10+6.88 cm, mass=64.09+8.72 kg) who participated on National Collegiate Athletic Association Division III lacrosse teams volunteered to participate. Independent variable was time (pre, post). …

Comparing The Incidence Of Head Impacts Sustained In Conference Versus Non-Conference Women’S Soccer Games, Courtney Acors

Student Scholar Showcase

Context: Investigating head impacts in women’s soccer has become of increased interest due to women’s soccer having one of the highest concussion injury rates among organized sports.

Objective: To determine frequency and magnitude differences in head impacts sustained by collegiate women’s soccer players during conference and non-conference game. Design: Descriptive epidemiology study.

Setting: Soccer fields. Participants: 24 intercollegiate women’s soccer players (age=19.65±1.27 years, height=165.80±4.87 cm, mass = 64.45±7.38 kg). Interventions: Game type served as the independent variable (non-conference and conference). We measured frequency and magnitude (peak linear accelerations in g-forces and peak rotational accelerations in deg/sec2) of head impacts with …

The Effects Of Soft Tissue Flossing On Hamstring Flexibility And Lower Extremity Power, Zack Maust

Student Scholar Showcase

Flossing includes wrapping a latex band around a joint or muscle group providing compression and partially occluding blood flow followed by performing exercises. Flossing is hypothesized to improve flexibility by dissipating myofascial adhesions. The purpose of this study was to determine if applying a floss band to the thigh would increase hamstring flexibility as well as lower extremity power. Our study included 21 active individuals(8 male, 13 female, 22.62±2.99 years, 171.52±9.08 cm, 73.57±11.37 kg).The participant first warmed up on a stationary bike, followed by hamstring flexibility measurement of supine hip flexion. After the flexibility test, we used a single-leg vertical …

"Get Tough!": A Case Study On The Development Of The Sport Ethic In Youth Lacrosse, Ross Budziszewski

Student Research Symposium

While participation in youth sport is often linked with positive psychosocial and physical outcomes (Holt et al., 2017), this context can also cultivate ideals that lead to the development of unethical beliefs and unsafe sport practices (Al-Yaarbi & Kavussanu, 2017). The sport ethic is described as the deviant overconformity by an athlete to fit societal expectations of a sport's high-performance culture (Hughes & Coakley, 1991). Strong beliefs in the sport ethic can lead to moral disengagement, antisocial behavior, and treating sport like warfare (Shields, Funk, & Bredemeier, 2015). Although the sport ethic has been widely studied in competitive adult sport, …

Sports Nutrition Project Based Learning Assignment Reflection, Guillermo Escalante

Q2S Enhancing Pedagogy

This is a reflection paper of a Sports Nutrition Project Based Learning Assignment that was developed at the 2018 Project Based Learning Workshop and implemented in the Winter 2019 session of KINE 382- Sports Nutrition.

Cellular And Molecular Neurosciences Neu 360, Joanna Burkhardt

Library Impact Statements

No abstract provided.

Small Molecule Kras Agonist For Mutant Kras Cancer Therapy., Ke Xu, Dongkyoo Park, Andrew T Magis, Jun Zhang, Wei Zhou, Gabriel L Sica, Suresh S Ramalingam, Walter J Curran, Xingming Deng

Articles, Abstracts, and Reports

BACKGROUND: Lung cancer patients with KRAS mutation(s) have a poor prognosis due in part to the development of resistance to currently available therapeutic interventions. Development of a new class of anticancer agents that directly targets KRAS may provide a more attractive option for the treatment of KRAS-mutant lung cancer.

RESULTS: Here we identified a small molecule KRAS agonist, KRA-533, that binds the GTP/GDP-binding pocket of KRAS. In vitro GDP/GTP exchange assay reveals that KRA-533 activates KRAS by preventing the cleavage of GTP into GDP, leading to the accumulation of GTP-KRAS, an active form of KRAS. Treatment of human lung cancer …

Synthesis And Antiproliferative Activities Of Conjugates Of Paclitaxel And Camptothecin With A Cyclic Cell-Penetrating Peptide, Naglaa Salem El-Sayed, Amir Nasrolahi Shirazi, Muhammad Imran Sajid, Shang Eun Park, Keykavous Parang, Rakesh Tiwari

Pharmacy Faculty Articles and Research

Cell-penetrating peptide [WR]5 has been previously shown to be an efficient molecular transporter for various hydrophilic and hydrophobic molecules. The peptide was synthesized using Fmoc/tBu solid-phase chemistry, and one arginine was replaced with one lysine to enable the conjugation with the anticancer drugs. Paclitaxel (PTX) was functionalized with an esterification reaction at the C20 hydroxyl group of PTX with glutaric anhydride and conjugated with the cyclic peptide [W(WR)4K(bAla)] in DMF to obtain the peptide-drug conjugate PTX1. Furthermore, camptothecin (CPT) was modified at the C(20)-hydroxyl group through the reaction with triphosgene. Then, it was conjugated with two functionalized cyclic peptides through …

The Landscape Of Cellular And Gene Therapy Products: Cost, Approvals, And Discontinuations, Vaishali Shukla, Enrique Seoane-Vazquez, Souhiela Fawaz, Lawrence M. Brown, Rosa Rodriguez-Monguio

Pharmacy Faculty Articles and Research

Background The past 10 years witnessed a significant increase in the approval of cellular and gene therapy products worldwide. The US Food and Drug Administration (FDA) approved 3 gene therapy products within the last 4 months of 2017. The objective of this study was to examine the approval characteristics, discontinuations and cost of all cellular and gene therapy products approved worldwide. Data and Methods We conducted an electronic search of approved cell and gene therapy products from the databases of the main drug regulatory agencies including the US Food and Drug Administration, the European Medicines Agency (EMA), the Korea Ministry …

Toward Reducing Stress And Anxiety In Nursing Students: Implementing An Evidence-Based Mindfulness Program, Susan Mckee

DNP Final Reports

Stress and anxiety are increasing in college students, especially in nursing students who complete didactic and clinical courses concurrently. Nursing students report feeling overwhelmed, with distress affecting academic performance and balance of school and personal demands. Mindfulness is an evidence-based method of reducing human suffering due to troubling conditions such as pain, chronic illness, or psychological issues including stress and anxiety. This paper addresses the state of the science of mindfulness and details the current mental health concerns of college students, specifically nursing students. The body of evidence, gathered through a systematic search, suggests that mindfulness reduces stress and anxiety …

Diabetes Shared Medical Appointment: An Evidence-Based Innovation Project, Mohamed Bojang

DNP Final Reports

The purpose of the evidence-based practice innovation project (EPIP) is to address uncontrolled diabetes by implementing an evidence-based shared medical appointment (SMA) intervention which based on the body of the evidence will help improve diabetes outcomes. A pilot implementation and retrospective chart review were conducted. Data was collected on outcome indicators such as blood pressure, lipid values, body mass index, A1C, and knowledge. The results of a pilot SMA implementation revealed that patients who participated in the weekly SMA saw an improvement in post-mean values compared to pre-mean values. Mean A1c dropped to 7.0% from 7.11%; systolic blood pressure improved …

An Evidence-Based Project: Implementing A Nursing Handoff Protocol To Improve Patient Outcomes, Marcella Y. Upshaw-Owens

DNP Final Reports

The role of handoff communication is known to impact the patient experience and other patient outcomes. Handoffs are a common practice in healthcare and occur multiple times a day for each patient. Nurses are involved in handoff each shift. Based on clinical inquiry, the following question was postulated: In acute care nurses, how does a standardized handoff communication protocol, compared to no standardized communication protocol, affect outcomes (i.e., patient satisfaction, falls, medication errors, and missed orders) within a 3-month period? After completion of a literature review and critical appraisal, a bedside report protocol was developed and implemented using the Iowa …

Theorizing The Social Determinants Of Breast Cancer In Sub-Saharan Africa: A Family Health Nursing Perspective, Rosemary W. Eustace, Tumaini Nyamhanga, Eunice Lee

Seminars in Local and Global Regional Economies

The aim of this presentation is to discuss the theorizing process of a Family Health Strength-Based Socio-Ecological Model of Breast Cancer in Sub-Saharan Africa and the model’s meaning to family nursing practice. The major purpose of theorizing this model is to explore the social determinants of breast cancer within and external to the family system. The model is developed based on key realities inductively generated from integrated and empirical evidence on breast cancer in the region. Understanding the social contexts of health from this multilevel holistic systems approach offers nurses opportunities to prioritize research and interventions in disease prevention and …

The Role Of Resilience And Preparedness In Nurses Working During Hurricane Disasters, Julie George

Nursing Theses and Dissertations

Problem: Resilience is the ability to “bounce back” from adversity and can serve as an avenue for nurses to recover from the disaster and subsequent potential issues related to coping with the event. To date, very little is found in the literature specific to nurses and how they adapt to and recover from disasters in their personal or professional lives.

Theory: Taormina’s (2015) theory of adult personal resilience and Veenema’s disaster management model (World Health Organization [WHO] and International Council of Nurses [ICN], 2009) provided the foundation of this study.

Hypothesis: It is hypothesized that levels of personal and professional …

Histological Chorioamnionitis Induces Differential Gene Expression In Human Cord Blood Mononuclear Leukocytes From Term Neonates., Suhita Gayen Nee’ Betal, Swati Murthy, Michael Favara, Gina Fong, Joanna Chan, Sankar Addya, Thomas H. Shaffer, Jay S. Greenspan, Vineet Bhandari, Irfan Rahman, Zubair H. Aghai

Department of Pediatrics Faculty Papers

Histological chorioamnionitis (HCA) is an infection of fetal membranes and complicates 5.2% to 28.5% of all live births. HCA is associated with increased mortality and morbidity in both premature and term neonates. Exposure to HCA may have long-term consequences, including an increased risk for allergic disorders and asthma later in childhood, the mechanism(s) of which are still not yet well understood. The objective of this study was to determine the mRNA transcriptome of cord blood mononuclear leukocytes from term neonates to identify key genes and pathways involved in HCA. We found 366 differentially expressed probe IDs with exposure to HCA …

Board Invited Review: Prospects For Improving Management Of Animal Disease Introductions Using Disease-Dynamic Models, Ryan S. Miller, Kim M. Pepin

United States Department of Agriculture Wildlife Services: Staff Publications

Management and policy decisions are continually made to mitigate disease introductions in animal populations despite often limited surveillance data or knowledge of disease transmission processes. Science-based management is broadly recognized as leading to more effective decisions yet application of models to actively guide disease surveillance and mitigate risks remains limited. Disease-dynamic models are an efficient method of providing information for management decisions because of their ability to integrate and evaluate multiple, complex processes simultaneously while accounting for uncertainty common in animal diseases. Here we review disease introduction pathways and transmission processes crucial for informing disease management and models at the …

The Anticipated Negative Impact On Emergency Medicine Faculty Of The New Acgme Common Program Requirements (Poster)., Shawn M. Quinn Do, Bryan G. Kane Md, Terrence E. Goyke, Dawn M. Yenser C-Tagme, Marna R. Greenberg Do, Mph, Facep, Gavin C. Barr Jr. Md

Department of Emergency Medicine

No abstract provided.

Body Mass Index In Multiple Sclerosis Modulates Ceramide-Induced Dna Methylation And Disease Course, Kamilah Castro, Achilles Ntranos, Mario Amatruda, Maria Petracca, Peter Kosa, Emily Y. Chen, Johannes Morstein, Dirk Trauner, Corey T. Watson, Michael A. Kiebish, Bibiana Bielekova, Matilde Inglese, Ilana Katz Sand, Patricia Casaccia

Advanced Science Research Center

Background: Multiple Sclerosis (MS) results from genetic predisposition and environmental variables, including elevated Body Mass Index (BMI) in early life. This study addresses the effect of BMI on the epigenome of monocytes and disease course in MS.

Methods: Fifty-four therapy-naive Relapsing Remitting (RR) MS patients with high and normal BMI received clinical and MRI evaluation. Blood samples were immunophenotyped, and processed for unbiased plasma lipidomic profiling and genome-wide DNA methylation analysis of circulating monocytes. The main findings at baseline were validated in an independent cohort of 91 therapy-naïve RRMS patients. Disease course was evaluated by a two-year longitudinal follow up …

Feasibility Of Incorporating Components Of A ‘Sex And Gender’ In Em Toolkit Into Residency Education, Alyson J. Mcgregor Md, Ma, Marna R. Greenberg Do, Mph, Facep, Rebecca Barron Md, Mph, Lauren A. Walter Md, Jeannette Wolfe Md, Ashley L. Deutsch Md, Steven A. Johnson Md, Derek A. Robinett Md, Gillian A. Beauchamp Md

Department of Emergency Medicine

No abstract provided.

Hallway Bed Status Is Associated With Lower Patient Satisfaction, Max Needham Ba, Kathryn B. Bartlett Do, Akshay Gupta Do, John J. Scholz Do, Jennifer Sadowski Do, Bryan G. Kane Md, Jeanne L. Jacoby Md, Marna R. Greenberg Do, Mph, Facep, David M. Richardson Md

Department of Emergency Medicine

No abstract provided.

Status Of Sex And Gender In Emergency Medicine A Five Year Follow Up Report, Basmah Safdar Md, Msc, Kimberly E. Ona Ayala Ba, Syed Shayan Ali Md, Benjamin J. Seifer Bsme, Michelle Hong Bs, Ms, Marna R. Greenberg Do, Mph, Facep, Esther K. Choo Md, Mph, Alyson J. Mcgregor Md, Ma

Department of Emergency Medicine

No abstract provided.

Identification Of Bird-Associated Nonpoint Sources Of Microbial Contamination In Sediments, Savannah D. Mullins

Honors College Theses

Fecal indicator bacteria (FIB), such as Enterococci, are commonly used to monitor the microbial contamination of recreational beach waters based on standards set by the United States Environmental Protection Agency. Sediment and sand may also harbor FIB and reintroduce these bacteria to the water column. Enterococci may be originated from various non-point sources such as humans and wildlife. Recent literature has shown that avian feces also harbor high concentrations of Enterococci. The purpose of this study is identify the relationship between Enterococci and avian-associated markers in sediments. Sediment samples were collected monthly from four sites at Kings Ferry Beach in …

Employee Experiences With A Newly Adopted Paid Parental Leave Policy: Equity Considerations For Policy Implementation, Dawn M. Richardson

OHSU-PSU School of Public Health Faculty Publications and Presentations

Purpose: Paid parental leave (PPL) policies offer immense opportunity to enhance health equity by providing financial stability to workers and promoting the health of families in the United States. Working in partnership with a local county government, which recently adopted a paid leave policy, we engaged in a qualitative substudy to enhance our understanding of how workers perceived and experienced the policy across levels of the socioecological framework. Methods: Working in partnership with Multnomah County, a large public-sector employer in Portland, OR that recently adopted a PPL policy, we collected qualitative data through focus groups with employees. Data were transcribed, …

Dietary Supplement Safety: A 25 Year Retrospective Assessment, Bill Gurley

Oxford ICSB

Passage of the Dietary Supplement Health & Education Act (DSHEA) in 1994 ushered in a new category of consumer products known as dietary supplements (DS). DSHEA’s definition of a dietary supplement encompasses a wide variety of products from multivitamins and single-ingredient botanical extracts, to “proprietary blends” of multiple botanical extracts and/or vitamins and minerals. Almost from their inception, safety concerns regarding certain categories of “proprietary blends” have plagued the DS industry. Most notable of these involved Ephedra-containing DS, whose questionable safety record led to their removal from the U.S. market in 2004 by the FDA after a 10-year period of …

Neuroscience Research Methods Neu 262, Joanna Burkhardt

Library Impact Statements

No abstract provided.

Beyond The Sentimental Cliche: How Local Communities Impact Residents And Shape Public Opinion, Kate Brunk

Theses and Dissertations

The Trump administration has recently established a rule that will prohibit abortion services providers from receiving Title X funds for the non-abortion family planning services they provide. Little public opinion research has focused on family planning and reproductive health topics outside of abortion. I find statistically significant experimental evidence that increasing perceptions of local need for a local reproductive health clinic caused subjects to be more supportive of federal reproductive health funding for local clinics. I did not find statistically significant correlational evidence that objective measures of poor reproductive health at the county level influence public opinion on federal reproductive …

Fluorometholone Modulates Gene Expression Of Ocular Surface Mucins, Jonathan Taniguchi, Ajay Sharma

Pharmacy Faculty Articles and Research

Purpose

Mucins are vital to keep the ocular surface hydrated. Genes encoding for mucins contain a glucocorticoid response element. The purpose of this study was to evaluate the effect of fluorometholone, a glucocorticoid receptor agonist used in the management of dry eye, on the gene expression of conjunctival and corneal epithelial cell mucins.

Methods

Stratified cultures of human conjunctival and corneal epithelial cells were exposed to 25, 50 and 100 nM of fluorometholone alone or in presence of mifepristone, a glucocorticoid receptor antagonist. The mRNA was isolated from the cells and reverse transcribed to cDNA. The cDNA was used for …

Eis Inhibitors, Sylvie Garneau-Tsodikova, Oleg V. Tsodikov

Pharmaceutical Sciences Faculty Patents

Compounds and compositions are disclosed, which are useful as inhibitors of acetyltransferase Eis, a mediator of kanamycin resistance in Mycobacterium tuberculosis.

Gray, Timothy L. (Fa 1280), Manuscripts & Folklife Archives

Folklife Archives Finding Aids

Finding aid only for Folklife Archives Project 1280. Student paper titled “Superstition or Belief on Coach and Athlete” in which Timothy Gray examines the relationships between sports players and their coaches through a folkloric lens. In his paper, Gray describes a brief history of how belief has impacted the ways in which sports are played and the effects, whether positive or negative, of enacting certain superstitious practices before games. The paper also includes a small collection of superstitions and beliefs gathered from close friends and professional coaches.