Medicine and Health Sciences Commons^™

Assessing The Impact Of Interprofessional Education On The Attitudes And Interprofessional Competencies Of Health Care Professionals: A Mixed Methods Study, Jessica L. Stadick

Electronic Theses and Dissertations

Purpose. The purpose of this study was to assess health care professional’s interprofessional collaborative competencies and attitudes towards working in teams and to examine if differences exist between professionals who have completed formal interprofessional education (IPE) and those who have not. This study was guided by the Interprofessional Learning Continuum Model.
Background. IPE is the foundation of interprofessional collaboration. Research has shown that IPE is an effective strategy to prepare health care professionals for collaborative practice; however, preventable medical errors that result from poor collaboration continues to plague the health care system. Thus, more research is needed to better …

Understanding Emotional Intelligence And Its Relationship To Clinical Reasoning In Nursing Students: A Mixed Methods Study, Heidi M. Meyer

Electronic Theses and Dissertations

Purpose. The purpose of this study was to explore emotional intelligence (EI) and its relationship to clinical reasoning in senior bachelor of science in nursing (BSN) students to gain a better understanding of how emotions are used in clinical learning experiences. This study was guided by the Four Branch Ability Model of EI.
Background. The current complex healthcare environment requires nursing students to be prepared to effectively reason in emotionally charged situations. The concept of EI and its beneficial effects in nursing are becoming more evident in the literature. However, it is still not well understood what the …

Level Of Satisfaction Among Food Pantry Clients, Staff/Volunteers, And Directors And Its Association With Client Choice In Food Pantry Layouts, Myranda Dunmire

Electronic Theses and Dissertations

Objectives: Food insecurity is an issue in rural communities, particularly among food pantry clients. Food pantries may not provide clients with the opportunity to choose their own foods (client choice), and instead may just give a set amount and type of foods. Client choice is important in regards to client health status as well as perceptions of autonomy and quality of life. Although client choice can be promoted in food pantries, it may be difficult to grasp the process of food pantry transitioning and how well changes such as these may be perceived by clients or food pantry personnel. We …

Lamotrigine Odt-Induced Seizure In A 3-Year-Old Child After Accidental Ingestion, Ashley Griswold Do, Briana Tully, Kenneth D. Katz Md, Gillian A. Beauchamp Md, Matthew D. Cook Do, Robert D. Cannon Do

Department of Emergency Medicine

Lamotrigine is a new generation antiepileptic which blocks sodium channels and can cause significant toxicity in overdose. A case of a three-year-old child who suffered a seizure and required endotracheal intubation after accidental lamotrigine ingestion is presented. The lamotrigine concentration measured 23.2 mcg/mL which is the highest reported after accidental pediatric exposure. A review of the literature regarding pediatric lamotrigine poisoning is also included.

The Association Between Health-Related Fitness And Physical Activity During Weekdays: Do Fit Students Exercise More After School?, Dehong Yang, Xihe Zhu, Justin A. Haegele, Patrick B. Wilson, Xueping Wu

Human Movement Studies & Special Education Faculty Publications

Physically active students are more likely to be fit and learn better in school than sedentary ones. For school-aged children, it is unclear whether physical fitness level is an important determinant for student's activity afterschool. This study examined the association between health-related physical fitness test performance and afterschool physical activity during weekdays. Participants (n = 97, 11-13 years old) completed health-related fitness tests. They wore Actigraph GT3X accelerometers for five consecutive days, recording physical activity participation during after school hours. Descriptive statistics for both afterschool physical activity and health-related fitness were summarized. Regression analyses were conducted to determine the association …

Effectiveness Of Surf Therapy For Children With Disabilities, Emily D. Clapham, Linda S. Lamont, Minsuk Shim, Shabnam Lateef, Cortney N. Armitano

Human Movement Studies & Special Education Faculty Publications

BACKGROUND: Few researchers have examined the effects of surf programs on children with disabilities. Due to previous research findings, surfing is being used, as the focus of physical activity intervention due to its numerous health and therapeutic benefits.

OBJECTIVE/HYPOTHESIS: The purpose of this study was to explore the effects of an eight-week surfing intervention on various physical fitness measures in 71 children with disabilities such as autism spectrum disorder, down syndrome, global developmental delays, and cerebral palsy. The study also sought to compare the differences in overall fitness levels between the surf therapy group and an unstructured pool playgroup. Researchers …

Walking Biomechanics And Energetics Of Individuals With A Visual Impairment: A Preliminary Report, Hunter J. Bennett, Kevin A. Valenzuela, Kristina Fleenor, Steven Morrison, Justin A. Haegele

Human Movement Studies & Special Education Faculty Publications

Purpose.

Although walking gait in sighted populations is well researched, few studies have investigated persons with visual impairments (VIs). Given the lack of physical activity in people with VIs, it is possible that reduced efficiency in walking could adversely affect activity. The purposes of this preliminary study were to (1) examine the biomechanics and energetics utilized during independent and guided walking in subjects with VIs, and (2) compare gait biomechanics between people with VIs and sighted controls.

Methods.

Three-dimensional motion capture and force platforms were used during independent and guided walking at self-selected speeds. Joint angles, moments, external work, and …

Going Rogue: Mobile Research Applications And The Right To Privacy, Stacey A. Tovino

Faculty Articles

This Article investigates whether nonsectoral state laws may serve as a viable source of privacy and security standards for mobile health research participants and other health data subjects until new federal laws are created or enforced. In particular, this Article (1) catalogues and analyzes the nonsectoral data privacy, security, and breach notification statutes of all fifty states and the District of Columbia; (2) applies these statutes to mobile-app-mediated health research conducted by independent scientists, citizen scientists, and patient researchers; and (3) proposes substantive amendments to state law that could help protect the privacy and security of all health data subjects, …

Burnout And Resilience Among Pediatric Residents In Stockholm, Sweden: Findings From A Mixed-Methods Study, Lauren Poull, Sanaz Skyttner-Rahmani, Andrea P. Anderson, Weston T. Powell, Jiaqi Yin, Carolyn C. Foster, Maneesh Batra

Posters

Objective

 To measure the prevalence of burnout among pediatric residents at Karolinska University Hospital (KUH).
 To describe the local drivers of burnout and the protective factors that lead to resilience and workplace engagement.

Conclusions

 Prevalence of burnout among Swedish pediatric residents in this study was 39%, which is lower than reported in the US (50-60%).
 Drivers of burnout were identified across all four domains. They included local features of the learning environment, and many are modifiable.
 Protective factors include perceived control over scheduling, better mental and physical health, lower perceived stress, and being a parent. …

The Effects Of Early Laxative, Diet, And Exercise Education On Postpartum Constipation Prevention, Amber Thompson

Doctor of Nursing Practice (DNP) Practice Innovation Projects

Introduction: Postpartum constipation is a common problem women face after delivery. Vaginal tears, pain medications, hormonal changes, decreased activity, dietary changes, and hemorrhoids can all increase the risk of developing constipation in the postpartum period. Evidence Summary: Constipation can cause pain, discomfort, decreased quality of life, and life-long consequences if left untreated. Nurses have a responsibility to the patient to provide quality care by taking a proactive approach to bowel management. Regular assessment of patient bowel habits and the provision of education on non-pharmacologic and pharmacologic prevention measures are recommended. Gaps: There is a lack of literature specific to constipation …

Eukaryotic Initiation Factor 3, Subunit C Silencing Inhibits Cell Proliferation And Promotes Apoptosis In Human Ovarian Cancer Cells, Fang Wen, Zhang-Ying Wu, Lei Nie, Qi-Zhu Zhang, Yuan-Kun Qin, Zun-Lun Zhou, Jin-Jian Wu, Xing Zhao, Jun Tan, Darrell Sawmiller, Dan Zi

Psychiatry & Behavioral Neurosciences Faculty Publications

Ovarian cancer remains the leading cause of death among all gynaecological cancers, illustrating the urgent need to understand the molecular mechanisms involved in this disease. Eukaryotic initiation factor 3c (EIF3c) plays an important role in protein translation and cancer cell growth and proliferation, but its role in human ovarian cancer is unclear. Our results showed that EIF3c silencing significantly up-regulated 217 and down-regulated 340 genes. Ingenuity Pathway Analysis (IPA) indicated that the top differentially expressed genes are involved in ‘Classical Pathways’, ‘Diseases and Functions’ and ‘Networks’, especially those involved in signalling and cellular growth and proliferation. In addition, eIF3c silencing …

Nasopharyngeal Angiofibroma: A Forgotten Entity In Older Patients, Vanessa C. Stubbs, Lauren E. Miller, Arjun K. Parasher, Jordan T. Glicksman, Nithin D. Adappa, James Palmer

Otolaryngology Head & Neck Surgery Faculty Publications

Introduction: Nasopharyngeal angiofibroma (NA) characteristically affects adolescent men. Although benign, these tumors can cause local destruction and surgical resection is warranted.

Objective: We present a case of a 62-year-old man with nasal congestion and epistaxis, found to be a right NA on pathology. We also present a review of the available NA staging systems.

Findings: In this case of NA, imaging revealed an aggressive, hypervascular mass in the nasal cavity with involvement of the middle cranial fossa and cavernous sinus. The patient underwent complete endoscopic surgical resection following vascular embolization.

Conclusion: Although it is rare, NA should not be disregarded …

Gutting The Brain Of Inflammation: A Key Role Of Gut Microbiome In Human Umbilical Cord Blood Plasma Therapy In Parkinson's Disease Model, Jea-Young Lee, Julian P. Tuazon, Jared Ehrhart, Paul R. Sanberg, Cesar V. Borlongan

Neurosurgery and Brain Repair Faculty Publications

Current therapies for Parkinson's disease (PD), including L-3,4-dihydroxyphenylalanine (L-DOPA), and clinical trials investigating dopaminergic cell transplants, have generated mixed results with the eventual induction of dyskinetic side effects. Although human umbilical cord blood (hUCB) stem/progenitor cells present with no or minimal capacity of differentiation into mature dopaminergic neurons, their transplantation significantly attenuates parkinsonian symptoms likely via bystander effects, specifically stem cell graft-mediated secretion of growth factors, anti-inflammatory cytokines, or synaptic function altogether promoting brain repair. Recognizing this non-cell replacement mechanism, we examined here the effects of intravenously transplanted combination of hUCB-derived plasma into the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced rat model of PD. …

Retrospective Case Series Of Traumatic Brain Injury And Post-Traumatic Stress Disorder Treated With Hyperbaric Oxygen Therapy, R. Douglas Shytle, David J. Eve, Soel-Hee Kim, Allan Spiegel, Paul R. Sanberg, Cesar V. Borlongan

Neurosurgery and Brain Repair Faculty Publications

Returning veterans are frequently diagnosed with traumatic brain injury (TBI) and post-traumatic stress disorder (PTSD). Considering a recent case-controlled study of hyperbaric oxygen therapy (HBOT) reporting a reduction in suicidal ideation, we investigated retrospectively three veterans with chronic TBI/PTSD symptoms who were treated with multiple rounds of HBOT with neurophysiological testing performed before and after treatment. Improvements were detected on parameters within neurocognitive domains, including reductions in suicide-related symptoms. These findings independently confirm that HBOT may be effective in treating specific symptoms of TBI/PTSD that are not currently addressed with existing therapeutic approaches.

Administration Of Rctrp9 Attenuates Neuronal Apoptosis Through Adipor1/Pi3k/Akt Signaling Pathway After Ich In Mice, Lianhua Zhao, John H. Zhang, Prativa Sherchan, Paul R. Krafft, Wei Zhao, Sa Wang, Shengpan Chen, Zaiyu Guo, Jiping Tang

Neurosurgery and Brain Repair Faculty Publications

Targeting neuronal apoptosis after intracerebral hemorrhage (ICH) may be an important therapeutic strategy for ICH patients. Emerging evidence indicates that C1q/TNF-Related Protein 9 (CTRP9), a newly discovered adiponectin receptor agonist, exerts neuroprotection in cerebrovascular disease. The aim of this study was to investigate the anti-apoptotic role of CTRP9 after experimental ICH and to explore the underlying molecular mechanisms. ICH was induced in mice via intrastriatal injection of bacterial collagenase. Recombinant CTRP9 (rCTRP9) was administrated intranasally at 1 h after ICH. To elucidate the underlying mechanisms, adiponectin receptor1 small interfering ribonucleic acid (AdipoR1 siRNA) and selective PI3 K inhibitor LY294002 were …

Pathophysiology Of Ganglioside Gm1 In Ischemic Stroke: Ganglioside Gm1: A Critical Review, Wenchao Zhang, Paul R. Krafft, Tianlong Wang, John H. Zhang, Li Li, Jiping Tang

Neurosurgery and Brain Repair Faculty Publications

Ganglioside GM1 is a member of the ganglioside family which has been used in many countries and is thought of as a promising alternative treatment for preventing several neurological diseases, including cerebral ischemic injury. The therapeutic effects of GM1 have been proved both in neonates and in adults following ischemic brain damage; however, its clinical efficacy in patients with ischemic stroke is still uncertain. This review examines the recent knowledge of the neuroprotective properties of GM1 in ischemic stroke, collected in the past two decades. We conclude that GM1 may have potential for stroke treatment, although we need to be …

Safety, Pharmacodynamics, And Potential Benefit Of Omaveloxolone In Friedreich Ataxia, David R. Lynch, Jennifer Farmer, Lauren Hauser, Ian A. Blair, Qing Qing Wang, Clementina Mesaros, Nathaniel Snyder, Sylvia Boesch, Melanie Chin, Martin B. Delatycki, Paola Giunti, Angela Goldsberry, Chad Hoyle, Michael G. Mcbride, Wolfgang Nachbauer, Megan O'Grady, Susan Perlman, S. H. Subramony, George R. Wilmot, Theresa A. Zesiewicz, Colin Meyer

Neurology Faculty Publications

Objective Previous studies have demonstrated that suppression of Nrf2 in Friedreich ataxia tissues contributes to excess oxidative stress, mitochondrial dysfunction, and reduced ATP production. Omaveloxolone, an Nrf2 activator and NF-kB suppressor, targets dysfunctional inflammatory, metabolic, and bioenergetic pathways. The dose-ranging portion of this Phase 2 study assessed the safety, pharmacodynamics, and potential benefit of omaveloxolone in Friedreich ataxia patients (NCT02255435).

Methods Sixty-nine Friedreich ataxia patients were randomized 3:1 to either omaveloxolone or placebo administered once daily for 12 weeks. Patients were randomized in cohorts of eight patients, at dose levels of 2.5–300 mg/day.

Results Omaveloxolone was well tolerated, and adverse …

Down The Rabbit Hole-Considerations For Ingested Foreign Bodies, Jerry Brown, Molly Kidder, Abigail Fabbrini, Jonathan Devries, Jason Robertson, Nicole Chandler, Michael Wilsey

Pediatrics Faculty Publications

We report the case of a seven-year-old boy with an ingested foreign body, which was retained within the appendix for a known duration of ten months, ultimately requiring appendectomy. The ingested foreign body was incidentally discovered by abdominal x-ray at an emergency room visit for constipation. Despite four bowel cleanouts, subsequent x-rays showed persistence of the foreign body in the right lower quadrant. While the patient did not have signs or symptoms of acute appendicitis, laparoscopic appendectomy was performed due to the risk of this foreign body causing appendicitis in the future. A small metallic object was found within the …

Folic Acid Intake, Fetal Brain Growth, And Maternal Smoking In Pregnancy: A Randomized Controlled Trial, Korede K. Yusuf, Hamisu M. Salihu, Roneé Wilson, Alfred K. Mbah, William Sappenfield, Karen Bruder, Usman J. Wudil, Muktar H. Aliyu

Obstetrics & Gynecology Faculty Publications

Background: Folic acid supplementation during pregnancy plays an important role in fetal growth and development. To our knowledge, no experimental study has examined the effect of folic acid on fetal brain growth in women who smoke cigarettes during pregnancy. Objectives: The aim of this study was to investigate the efficacy of higher-dose compared with standard-dose folic acid supplementation on prenatal fetal brain growth, measured by head circumference, brain weight, and brain-body weight ratio (BBR). Design: In this randomly assigned, double-blind, controlled clinical trial, we recruited 345 smoking pregnant women attending a community health center in Tampa, FL between 2010 and …

Ampk: A Balancer Of The Renin–Angiotensin System, Jia Liu, Xuan Li, Qingguo Lu, Di Ren, Xiaodong Sun, Thomas Rousselle, Ji Li, Jiyan Leng

Surgery Faculty Publications

The renin–angiotensin system (RAS) is undisputedly well-studied as one of the oldest and most critical regulators for arterial blood pressure, fluid volume, as well as renal function. In recent studies, RAS has also been implicated in the development of obesity, diabetes, hyperlipidemia, and other diseases, and also involved in the regulation of several signaling pathways such as proliferation, apoptosis and autophagy, and insulin resistance. AMP-activated protein kinase (AMPK), an essential cellular energy sensor, has also been discovered to be involved in these diseases and cellular pathways. This would imply a connection between the RAS and AMPK. Therefore, this review serves …

Observations On Multi-Generational Interactions In Academic Surgical Practice And Rducation, Fernando A. M. Herbella, Vic Velanovich

Surgery Faculty Publications

No abstract provided.

Giving To The Giver: A Research Proposal On Implementing Donor Nutrition Education To Promote Healthier Options In The Food Bank, Antionette Rivera, David Pantagan, Tavia Hunt, Mia Mitnaul, Chelsa Johnson, Joana San Luis, Kirstine Huey

OUR Journal: ODU Undergraduate Research Journal

Objective: To increase the nutritional value of donations given by donor organizations to the Food Bank based on a Red-Yellow-Green (RYG) scale. Background: Food banks have been planted across the Southeastern Virginia region to help with the prevalent issue of food insecurity. The food bank receives various food donations. The goal, however, is to implement education to the donor organizations to improve the nutritional value of the donations based on the Red-Yellow-Green scale. Participants and Methods: A Quasi-Experimental Before-and-After design across multiple groups will be used. Consistent donor groups will be selected for the intervention and baseline …

Medications And Patient Safety In The Trauma Setting: A Systematic Review, Jonathan H. Deantonio, Tammy Nguyen, Gregory Chenault, Michel B. Aboutanos, Rahul J. Anand, Paula Ferrada, Stephanie Goldberg, Stefan W. Leichtle, Levi D. Procter, Edgar B. Rodas, Alan P. Rossi, James F. Whelan, V. Ramana Freeser, Michael J. Vitto, Beth Broering, Sarah Hobgood, Martin Mangino, Dayanjan S. Wijesinghe, Sudha Jayaraman

Surgery Publications

Background: Medication errors account for the most common adverse events and a significant cause of mortality in the USA. The Joint Commission has required medication reconciliation since 2006. We aimed to survey the literature and determine the challenges and effectiveness of medication reconciliation in the trauma patient population.


Materials and methods: We conducted a systematic review of the literature to determine the effectiveness of medication reconciliation in trauma patients. English language articles were retrieved from PubMed/Medline, CINAHL, and Cochrane Review databases with search terms “trauma OR injury, AND medication reconciliation OR med rec OR med rek, AND effectiveness OR …

Acceptability And Adequacy Of Vaginal Self Sampling For Hpv Dna Testing In Cervical Cancer Screening Among Women Attending A Tertiary Hospital Clinics In Nairobi Kenya, Sagal Omar Salad

Master of Medicine in Anatomic Pathology

Background: Cervical cancer is a main concern of women’s health globally. In Kenya, Cervical cancer is the second most common cancer in women and the leading causes of cancer related deaths. Several screening methods exist including cytology, human papilloma virus DNA test and visual inspection with Acetic Acid or Lugol’s Iodine (VIA/VILI). The current screening rate uptake in Kenya is poor, HPV DNA self-sampling may have a role in increasing the screening uptake as many studies have shown that self-sampling for HPV DNA testing is acceptable, though some others favoured over self-sampling. This study aims to assess whether vaginal HPV …

Assessment And Analysis Of H.Pylori Infection Treatment Strategies Of St. Vincent Hospital's Family And Internal Medicine Clinics, Rebecca Orr

Undergraduate Honors Thesis Collection

Helicobacter pylori is a gram-negative bacteria that is responsible for causing chronic gastritis, ulcers in the stomach and intestine, and eventually even gastric lymphoma or cancer. Multiple treatment options have been recommended for treating an H. pylori infection based on kidney function, previous antibiotic exposure, and whether or not the infection is recurrent. The most common regimens used at St. Vincent's primary care centers closely mimic the American College of Gastroenterology's clinical guidelines. However, these medications (clarithromycin and levofloxacin) have been associated with high rates of resistance in other countries. The United States has very limited data on H. pylori's …

The Effect Of Estrogen And Chronic Mild Stress On Gabaergic System And Anxiety- Like Behavior In Ovariectomized Rat, Sushawadee Tongta

Chulalongkorn University Theses and Dissertations (Chula ETD)

Stress in daily life and estrogen deprivation are known factors contributed to anxiety and depression. In animal models, anxiety-liked behaviors were demonstrated in ovariectomized or stress-exposed subjects. However, it was not clarified whether anxiety-liked behavior would be worsen when ovariectomized animals were exposed to mild stressors. The aims of this study were then designed to investigate (1) the effect of estrogen deprivation and chronic mild stresses (CMS) on anxiety- and depressive-liked behaviors and (2) the effect of estrogen receptor activation i.e. ERβ or GPR30 in estrogen deprivation exposed to CMS on anxiety-liked behavior. The alterations of GABAergic transmission in the …

ประสิทธิศักย์ในการปรับภูมิคุ้มกันและความปลอดภัยของการเสริมสปอร์เห็ดหลินจือต่อผู้ป่วยหลังได้รับยาเคมีบำบัด, พิไลลักษณ์ ตังคพิพัฒน์

Chulalongkorn University Theses and Dissertations (Chula ETD)

สปอร์เห็ดหลินจือมีสารสำคัญออกฤทธิ์กระตุ้นการทำงานของเซลล์ในระบบภูมิคุ้มกัน เซลล์เหล่านี้ใช้เวลาในการฟื้นตัวมากกว่า 9 เดือนหลังจากผู้ป่วยมะเร็งหยุดยาเคมีบำบัด จึงนำมาสู่การศึกษาครั้งนี้โดยมีวัตถุประสงค์เพื่อศึกษาผลของสปอร์เห็ดหลินจือที่มีต่อระบบภูมิคุ้มกันในผู้ป่วยมะเร็งเต้านม ผู้ป่วยมะเร็งลำไส้ใหญ่หรือทวารหนักหลังครบการรักษาด้วยยาเคมีบำบัดในช่วงเดือนพฤศจิกายน พ.ศ. 2561 ถึงธันวาคม พ.ศ. 2562 การศึกษานี้เป็นการศึกษาทางคลินิกแบบสุ่ม ปกปิด 2 ทาง มีการเปรียบเทียบกับกลุ่มควบคุม โดยกลุ่มตัวอย่างที่เข้าร่วมการศึกษาจนครบการศึกษาทั้งสิ้น 44 ราย แบ่งโดยการสุ่มเป็น 2 กลุ่มเท่า ๆ กัน ได้แก่ กลุ่มที่ได้สปอร์เห็ดหลินจือที่ผ่านการกะเทาะขนาด 250 มิลลิกรัมและกลุ่มที่ได้ยาหลอก รับประทานผลิตภัณฑ์ครั้งละ 1 แคปซูล วันละ 3 ครั้ง ก่อนอาหาร เป็นระยะเวลา 8 สัปดาห์ วัดระดับอิมมูโนโกลบูลิน (IgG, IgM, IgA และ IgE) ความสมบูรณ์เม็ดเลือด ค่าการทำงานของตับและไต อาการไม่พึงประสงค์ ณ สัปดาห์ที่ 0, 4 และ 8 รวมไปถึงประเมินคุณภาพชีวิตด้วยแบบประเมิน FACT-G ก่อนและหลังเข้าร่วมการศึกษา พบว่า สัปดาห์ที่ 8 กลุ่มที่ได้สปอร์เห็ดหลินจือมีการเปลี่ยนแปลงของระดับอิมมูโนโกลบูลิน เม็ดเลือดแดง เม็ดเลือดขาวชนิด neutrophil basophil eosinophil monocyte และเกล็ดเลือดไม่แตกต่างอย่างมีนัยสำคัญเมื่อเปรียบเทียบกับกลุ่มที่ได้ยาหลอก ในขณะที่จำนวนเม็ดเลือดขาวทั้งหมดและ absolute neutrophil count ในกลุ่มที่ได้สปอร์เห็ดหลินจือมีระดับเพิ่มขึ้นอย่างมีนัยสำคัญเมื่อเปรียบเทียบกับกลุ่มที่ได้ยาหลอก (p-value= 0.031 และ 0.021 ตามลำดับ) ผู้เข้าร่วมการศึกษาทั้ง 2 กลุ่มมีการเปลี่ยนแปลงของค่าการทำงานของตับและไตอย่างไม่มีนัยสำคัญตลอดระยะเวลาการศึกษา อาการไม่พึงประสงค์ที่พบ เช่น ปากแห้ง คอแห้ง คลื่นไส้ เป็นต้น มีความรุนแรงระดับน้อย นอกจากนี้กลุ่มที่ได้สปอร์เห็ดหลินจือมีคุณภาพชีวิตไม่แตกต่างอย่างมีนัยสำคัญเมื่อเปรียบเทียบกับกลุ่มที่ได้ยาหลอก กล่าวโดยสรุป การรับประทานสปอร์เห็ดหลินจือในขนาดที่ศึกษามีความปลอดภัยสามารถเพิ่มจำนวนเม็ดเลือดขาวทั้งหมดและ ANC ของผู้ป่วยมะเร็งหลังได้รับยาเคมีบำบัดได้ แต่ไม่สามารถเพิ่มระดับอิมมูโนโกลบูลินได้อย่างมีนัยสำคัญ

การพัฒนาผลิตภัณฑ์โทนเนอร์จากสารสกัดใบฝรั่งเพื่อยับยั้งแบคทีเรียบนผิวหนังของเยาวชนภายหลังการออกกำลังกาย, ทิทยุต วงษาเนาว์

Chulalongkorn University Theses and Dissertations (Chula ETD)

การศึกษานี้มีวัตถุประสงค์ 1) เพื่อพัฒนาผลิตภัณฑ์โทนเนอร์จากสารสกัดใบฝรั่งที่มีประสิทธิศักย์ยับยั้งเชื้อแบคทีเรีย Staphylococcus aureus ได้เทียบเท่ากับสารอ้างอิงและยับยั้งเชื้อแบคทีเรียได้ตามวิธีมาตรฐานของ BS EN 1276 : 2009 2) ศึกษาความปลอดภัย และ 3) เพื่อศึกษาประสิทธิศักย์ของผลิตภัณฑ์ในการยับยั้งเชื้อแบคทีเรียบนผิวหนังและการลดการหลั่งเหงื่อของเยาวชนภายหลังการออกกำลังกายโดยไม่มีผลกระทบต่อการระบายความร้อน และมีการควบคุมคุณภาพของสารสำคัญทางธรรมชาติในสารสกัดใบฝรั่งรวมทั้งการทดสอบฤทธิ์ในการยับยั้งและฆ่าเชื้อแบคทีเรีย กลุ่มตัวอย่างในการทดสอบการแพ้โทนเนอร์จากสารสกัดใบฝรั่งด้วยวิธีแผ่นแปะเป็นนิสิตชายและหญิง คณะวิทยาศาสตร์การกีฬา จุฬาลงกรณ์มหาวิทยาลัย อายุ 18 – 24 ปี จำนวน 40 คน ได้รับการแปะแผ่นทดสอบบนผิวหนังทิ้งไว้ 24 ชั่วโมง จากนั้นถ่ายภาพบริเวณที่ทดสอบและนำไปใช้ประเมินปฏิกิริยาการแพ้ที่ผิวหนัง กลุ่มตัวอย่างในการศึกษาประสิทธิศักย์ของโทนเนอร์จากสารสกัดใบฝรั่งต่อเชื้อแบคทีเรียบนผิวหนังและการระงับการหลั่งเหงื่อภายหลังการออกกำลังกายเป็นนิสิตคณะวิทยาศาสตร์การกีฬา จุฬาลงกรณ์มหาวิทยาลัย อายุ 18 – 24 ปี จำนวน 64 คน ทุกคนได้เข้ารับการทดสอบพื้นฐาน จากนั้นทำการสุ่มกลุ่มตัวอย่างเพื่อเข้ารับการทดสอบแบบไขว้ปกปิดด้านเดียว (The single - blind, randomized, placebo – controlled crossover trial) เปรียบเทียบระหว่างโทนเนอร์จากสารสกัดใบฝรั่งและสารลวงโดยมีระยะห่างแต่ละการทดสอบ 7 วัน กลุ่มตัวอย่างวิ่งบนลู่กลความหนัก 75 % ของอัตราการเต้นหัวใจสำรอง เป็นเวลา 5 นาที มีการเก็บข้อมูลก่อนและหลังทดลอง คือ น้ำหนักเหงื่อ อัตราการเต้นหัวใจ อุณหภูมิผิวกาย และน้ำมันผิวหนัง วิเคราะห์ข้อมูลด้วยสถิติการวิเคราะห์ความแปรปรวนแบบทางเดียว การวิเคราะห์ความแปรปรวนทางเดียวแบบวัดซ้ำ การวิเคราะห์ความแปรปรวนสองทางแบบวัดซ้ำ การวิเคราะห์ความแปรปรวนร่วมแบบทางเดียว และเปรียบเทียบความแตกต่างแบบรายคู่โดยใช้วิธีของบอนเฟอร์โรนี (Bonferroni) ที่ระดับความมีนัยสำคัญทางสถิติ 0.05 ผลการศึกษา พบว่า โทนเนอร์จากสารสกัดใบฝรั่งมีประสิทธิศักย์ในการยับยั้งเชื้อ Staphylococcus aureus ได้เทียบเท่ากับยา 0.5 % คลอร์เฮกซิดีน มีประสิทธิศักย์ในการยับยั้งเชื้อแบคทีเรียผ่านตามวิธีมาตรฐานตลอดจนแสดงผลการแพ้ที่ผิวหนังอย่างไม่มีนัยสำคัญ มีประสิทธิศักย์ยับยั้งเชื้อแบคทีเรียบนผิวหนังของเยาวชนภายหลังการออกกำลังกายได้ดีที่สุดเมื่อเปรียบเทียบกับสารลวงและการทดสอบพื้นฐาน และสามารถลดการหลั่งเหงื่อได้ดีกว่าสารลวงและการทดสอบพื้นฐานอย่างมีนัยสำคัญทางสถิติที่ระดับ 0.05 โดยไม่มีผลต่อการระบายความร้อนของร่างกาย สรุป ผลิตภัณฑ์โทนเนอร์จากสารสกัดใบฝรั่งเป็นผลิตภัณฑ์สำหรับใช้ภายหลังการออกกำลังกายที่ลดการหลั่งเหงื่อ ลดกลิ่นเหงื่อและกลิ่นตัว โดยไม่มีผลต่อการระบายความร้อนของร่างกาย และไม่ทำให้เกิดการแพ้ต่อผิวหนัง

A Qualitative Evaluation Of A Young Parents Program (Ypp) - Parent And Facilitator Perspectives, Cecily Strange, Elaine Bennett, Maggie Tait, Yvonne Hauck

Nursing Papers and Journal Articles

Issue addressed: Young parents (<25 years) have lower engagement with health and community services and are more likely to experience negative outcomes in the perinatal period compared to older parents. The aim of this study was to evaluate the short to medium‐term outcomes of the Young Parents Program (YPP), specifically designed to engage and support young parents, using responsive and codesign strategies in a community setting.

Methods: A qualitative case study used data from interviews with participating parents (n = 20) and a focus group with YPP facilitators (n = 5).

Results: The findings report on the following short to medium‐term YPP outcomes for parents and children. Young parents: are engaged in early parenting services that are welcoming, non-judgemental and holistic; build parenting skills, knowledge, confidence and are tuned into their infants’ needs; are empowered to codesign program activities to meet their parenting and non-parenting needs; have developed friendships and a social support network in their local community; and, are linked …

Effects Of Person-Centered Care At The Organizational-Level For People With Dementia. A Systematic Review, Lynette Chenoweth, Jane Stein-Parbury, Samuel Lapkin, Alex Wang, Zhixin Liu, Anna Williams

Nursing Papers and Journal Articles

The aim of the systematic review was to determine the effectiveness of organizational-level person-centered care for people living with dementia in relation to their quality of life, mood, neuropsychiatric symptoms and function. ALOIS, the Cochrane Dementia and Cognitive Improvement Group Specialised Register databases, were searched up to June 2018 using the terms dementia OR cognitive impairment OR Alzheimer AND non-pharmacological AND personhood OR person-centered care. Reviewed studies included randomized controlled trials (RCTs), cluster-randomized trials (CRTs) and quasi-experimental studies that compared outcomes of person-centered care and usual (non-person-centered) care, for people with a diagnosis of dementia. The search yielded 12 eligible …