Medicine and Health Sciences Commons^™

Technical Aspect Of Mechanical Thrombectomy Of Acute Ischemic Stroke, Ahmed El-Bassiouny, Magdy Khalaf, Romany Adly

Journal of Medicine in Scientific Research

Background and purpose Mechanical thrombectomy was recently reported of having the potential to treat acute ischemic stroke. However, few comparative studies on neurothrombectomy devices are reported. This study aims to compare two retrievable stent systems according to their safety and effectiveness in patients with acute ischemic stroke. Patients and methods In this study, the clinical, radiological, and functional outcomes of 20 patients with acute ischemic stroke are compared prospectively. Patients were treated with either Trevo retriever (TR) or Solitaire stent (ST) according to the neurointerventionalist preference. Successful recanalization was defined as thrombolysis in cerebral ischemia grade 2a to 3. Results …

Association Study Between Polymorphisms Of Dopamine Transporter Gene (Slc6a3), Dopamine D1 Receptor Gene (Drd1), And Autism, Azza Abdel Aziz Azzam, Dina Mohammad Rasheed Bahgat, Ranaih Massoud Azme Nasralla, Rasha Mohamad Hosny Shahin

Journal of Medicine in Scientific Research

Introduction Autism is an etiologically and clinically heterogeneous group of disorders, collectively referred to as 'autism spectrum disorders'. Dopamine (DA) modulates a wide variety of processes, functions, and behaviors that are abnormal in individuals with autism spectrum disorders. The DA transporter gene SLC6A3 (solute carrier family 6, member 3) is a crucial regulator of DA homeostasis and neurotransmission. SLC6A3 gene has many polymorphisms which are associated with hangs in gene expression that may affect extracellular DA levels. The rs2550936 single-nucleotide polymorphism (SNP) at SLC6A3 gene decreased SLC6A3 expression or DA transporter availability. Also, the rs4532 SNP at dopamine D1 receptors …

Surgical Interventions For Distal Radius Fractures, Jake Dotseth

Undergraduate Research Celebration 2018

No abstract provided.

A Spectrum Of Experience: A Community Art Project To Build Empathy Through Identity Sharing In A Suburban High School, Allison Stansfield

Expressive Therapies Capstone Theses

Having empathy for others is an important aspect of living within a healthy community. However, teaching empathy can be difficult. High school is a natural setting for learning and developing many social skills. If adolescents can learn to develop empathy at this age, they can carry it with them into their future communities. Research shows that story-telling and shared experiences have the potential to foster empathy. This paper describes a community-based art project within a suburban high school that was designed to use personal narrative and art-making as a way of developing a sense of empathy in adolescent-aged students. Students …

Epigenetic Regulation Of Tumor Suppressors By Helicobacter Pylori Enhances Ebv-Induced Proliferation Of Gastric Epithelial Cells, Saurabh Pandey, Hem Chandra Jha, Sanket Kumar Shukla, Meghan K. Shirley, Erle S. Robertson

Department of Medicine Faculty Papers

Helicobacter pylori and Epstein-Barr virus (EBV) are two well-known contributors to cancer and can establish lifelong persistent infection in the host. This leads to chronic inflammation, which also contributes to development of cancer. Association with H. pylori increases the risk of gastric carcinoma, and coexistence with EBV enhances proliferation of infected cells. Further, H. pylori-EBV coinfection causes chronic inflammation in pediatric patients. We have established an H. pylori-EBV coinfection model system using human gastric epithelial cells. We showed that H. pylori infection can increase the oncogenic phenotype of EBV-infected cells and that the cytotoxin-associated gene (CagA) protein encoded by H. …

How Laboratory Informatics Has Impacted Healthcare Overall, Mohammad Rafid Raeen

Applied Research Projects

Health information technology has improved key areas of healthcare such as academia, research, and practice. Technology is one of the key driving forces in healthcare that is set to enhance the overall provider-patient experience. The future of healthcare is aimed at improving patient satisfaction, quality of care, and practice methods. Laboratory information systems (LIS) is a fundamental component of the diagnostic or pathology department (Henricks, 2016). In the era, where laboratory reports have become complex and high-dimensional, the need to develop and implement a cost-effective platform or tool to collect, process, store, and manage such processes is required. A systematic …

Identifying Barriers That Affect Patients Access To Their Patient Portals And Mhealth Applications, Rameria L. Stewart

Applied Research Projects

Technological advances have generated new resources that allow patients to be more involved in their healthcare. As different innovations find their way into the informatics sector of healthcare, patients experience some challenges as they try to adopt these innovations. One particular innovation in healthcare has been the use of patient portals to promote patient engagement, which will encourage patients to take on a more active role in their healthcare. This study focused in exploring the barriers in the access of MyChart portal at Baptist Memorial Care Corporation and, to some extent, how to handle this problem. An online survey …

Bilateral Facial Spasm Following Guillain-Barré Syndrome, Zain Guduru, John Morgan, Kapil Sethi

Neurology Faculty Publications

Background: We report a patient who developed lower facial muscle spasm at rest and bilateral facial synkinesis several months after treatment of Guillain–Barré syndrome (GBS); this finding, to our knowledge, is hitherto unreported.

Phenomenology Shown: Bilateral synkinesis, facial muscles spasm at rest, bilateral postparalytic facial syndrome.

Educational Value: Aberrant regeneration of nerve fibers post GBS, resulting in facial muscles spasm at rest, bilateral synkinesis.

Stability Of Extemporaneously Prepared Ophthalmic Solutions For Mydriasis, Nicole A. Camp, Jennifer T. Nadra, Susan E. Hughes, Justine M. Gilbert, Fang Zhao

Doctoral External Publications

Purpose Results of an evaluation of the physical and chemical stability of extemporaneously prepared adult and pediatric ophthalmic solutions containing combinations of phenylephrine, tropicamide, and cyclopentolate are reported.

Methods A stability study was conducted to help determine the feasibility of innovative formulations to meet an unmet clinical need for combination mydriatic ophthalmic eyedrops. An adult mydriatic ophthalmic solution containing phenylephrine hydrochloride 2.5% and tropicamide 1.0% and a pediatric formulation containing phenylephrine hydrochloride 2.5%, tropicamide 0.5%, and cyclopentolate hydrochloride 0.5% were prepared using proper aseptic techniques. Triplicate samples of each formulation were stored for 60 days at refrigeration temperatures (2–8 °C) …

Skin-To-Skin Contact In The Operating Room Following Cesarean Birth, Tara M. Nordberg

Nursing Capstones

No abstract provided.

Fetal Demise And Failed Antibody Therapy During Zika Virus Infection Of Pregnant Macaques, Diogo M. Magnani, Thomas F. Rogers, Nicholas J. Maness, Nathan D. Grubaugh, Nathan Beutler, Varian K. Bailey, Lucas Gonzalez-Nieto, Martin J. Gutman, Núria Pedreño-Lopez, Jaclyn M. Kwal, Michael J. Ricciardi, Tereance A. Myers, Justin G. Julander, Rudolf P. Bohm, Margaret H. Gilbert, Faith Schiro, Pyone P. Aye, Robert V. Blair, Mauricio A. Martins, Kathrine P. Falkenstien, Amitinder Kaur, Christine L. Curry, Esper G. Kallas, Ronald C. Desrosiers, Pascal J. Goldschmidt-Clermont, Stephen S. Whitehead, Kristian G. Andersen, Myrna C. Bonaldo, Andrew A. Lackner, Antonito T. Panganiban, Dennis R. Burton, David I. Watkins

Animal, Dairy, and Veterinary Science Faculty Publications

Zika virus (ZIKV) infection of pregnant women is associated with pathologic complications of fetal development. Here, we infect pregnant rhesus macaques (Macaca mulatta) with a minimally passaged ZIKV isolate from Rio de Janeiro, where a high rate of fetal development complications was observed. The infection of pregnant macaques with this virus results in maternal viremia, virus crossing into the amniotic fluid (AF), and in utero fetal deaths. We also treated three additional ZIKV-infected pregnant macaques with a cocktail of ZIKV-neutralizing human monoclonal antibodies (nmAbs) at peak viremia. While the nmAbs can be effective in clearing the virus from …

Correcting For The Inconveniences Of Cultivation: Foraging As A Food Source In Southwestern Burkina Faso, Julia Deryn Morgan

Geography Honors Projects

Malnutrition is an important public health issue in Burkina Faso where 30 % of children are underweight for their age and 92% suffer from iron deficiency. Such statistics indicate that there is a significant lack of adequate nutrition in the country. With approximately 80% of the population employed in the agricultural sector, development projects have focused on increasing agricultural production and commercializing output to ameliorate poor nutrition. However, this strategy ignores the importance of local knowledge and food traditions, most notably by neglecting to acknowledge foraging as a significant source of food. To address this concern, I seek to understand …

Contrast-Enhanced Ultrasound Identifies Early Extrahepatic Collateral Contributing To Residual Hepatocellular Tumor Viability After Transarterial Chemoembolization., Sriharsha Gummadi, Maria Stanczak, Andrej Lyshchik, Flemming Forsberg, Colette M. Shaw, John R. Eisenbrey

Department of Radiology Faculty Papers

The mainstay of treatment for unresectable hepatocellular carcinoma is locoregional therapy including percutaneous ablation and transarterial chemo- and radioembolization. While monitoring for tumor response after transarterial chemoembolization is crucial, current imaging strategies are suboptimal. The standard of care is contrast-enhanced magnetic resonance imaging or computed tomography imaging performed at least 4 to 6 weeks after therapy. We present a case in which contrast-enhanced ultrasound identified a specific extra-hepatic collateral from the gastroduodenal artery supplying residual viable tumor and assisting with directed transarterial management.

Health Care Transition Experience Of Emerging Adults With Sickle Cell Disease: Preliminary Results, Dora L. Clayton-Jones

College of Nursing Faculty Research and Publications

No abstract provided.

Solution Growth And Thermal Treatment Of Crystals Lead To Two New Forms Of 2-((2,6-Dimethylphenyl)Amino)Benzoic Acid, Rong Hu, Yunping Zhoujin, Meng Liu, Mingtao Zhang, Sean Parkin, Panpan Zhou, Jianzhi Wang, Faquan Yu, Sihui Long

Chemistry Faculty Publications

We report the discovery of two new forms (II and III) of a potential non-steroidal anti-inflammatory and thyroid drug, 2-((2,6-dimethylphenyl)amino)benzoic acid (HDMPA) through solution growth and thermal treatment of crystals. Form II has been discovered through crystal growth in a variety of solvents, and characterized by single-crystal X-ray diffraction, powder X-ray diffraction (PXRD), FT-IR, and Raman spectroscopy. Form II converts into form III upon thermal treatment, as indicated by the phase behavior study of form II with differential scanning calorimetry (DSC). Form III has been characterized by IR, Raman and PXRD. Conformational flexibility of the molecule seems to lead to …

Prevalence Of Prediabetes, Diabetes, And Its Associated Risk Factors Among Males In Saudi Arabia: A Population-Based Survey, Khaled K. Aldossari, Abdulrahman Aldiab, Jamaan M. Al-Zahrani, Sameer H. Al-Ghamdi, Mohammed Abdelrazik, Mohammed Ali Batais, Sundas Javad, Shanila Nooruddin, Hira Abdul Razzak, Ashraf El-Metwally

Department of Paediatrics and Child Health

Objectives: The study aims at determining the prevalence of prediabetes and diabetes and at ascertaining some concomitant risk factorsamong males in Saudi Arabia.
Methods: A population-based cross-sectional study including 381 Saudi adult males from different institutions was recruited. Odds ratios for diabetes risk and risk factors were calculated using log-binomial and multinomial logistic regression, using STATA version 12.
Results: The participants included 381 diabetic males with a median age of 45 years, average body mass index of 25 ± 40 kg/m², whereas waist circumferences ranged from 66 to 180 cm in the male study population. In addition, 27.82% …

Where Trying To Conceive Becomes A Community Effort: A Digital Ethnography Of Online Infertility Forums, Megan Burns

Sociology Honors Papers

Online forums for women using in vitro fertilization (IVF), or similar assisted reproductive technologies (ARTs), provide a useful setting to further evaluate and understand women’s expectations of motherhood, the relationship infertile women have with physicians and biomedicine, and their interactions on the forums. Some critics of ARTs consider them a tool of oppression in a pronatalist state. The pressure and desire to become a biological mother leads the women with access to these technologies to use them regardless. Through digital ethnographic research on four online ART forums, this research examines the intersection of altruism and self-interest in the ways forum-users …

Neuroscience Subject Guide For The University Of Miami, Maya Lubarsky

Library Research Scholars Program 2017-2018

The Neuroscience Subject Guide was developed in 2018 by Maya Lubarsky as part of her Library Research Scholars Program. The Subject Guide aims to aid Neuroscience students in guiding their research and improving their research skills. It also includes a comprehensive background on the development of the Neuroscience program at the University of Miami.

Genomic Profiling Of Two Histologically Distinct Rare Urothelial Cancers In A Clinical Setting To Identify Potential Therapeutic Options For Treatment And Management Of Disease., Andrew N Hesse, William Fabricius, Christian A Thomas, Ramesh Gaindh, Robert Christman, Pavalan Selvam, Matthew Prego, Gregory Lewis, Jasmina Uvalic, Daniel Bergeron, Shelbi Burns, Bridgette Sisson, Kevin Kelly, Jens Rueter, Honey V Reddi

Faculty Research 2018

Molecular profiling of urothelial cancers for therapeutic and prognostic potential has been very limited due to the absence of cancer-specific targeted therapies. We describe here 2 clinical cases with a histological diagnosis of an invasive sarcomatoid and a poorly differentiated carcinoma favoring urothelial with some neuroendocrine differentiation, two of the rarer types of urothelial cancers, which were evaluated for mutations in 212 genes for single-nucleotide variants and copy-number variants and 53 genes for fusions associated with solid tumors. In both cases, we identified variants in 2 genes, Case Rep Oncol 2018 Mar 27; 11(1):196-205.

Genomic Dna Methylation-Derived Algorithm Enables Accurate Detection Of Malignant Prostate Tissues, Erfan Aref-Eshghi, Laila C Schenkel, Peter Ainsworth, Hanxin Lin, David I Rodenhiser, Jean-Claude Cutz, Bekim Sadikovic

Paediatrics Publications

Introduction

The current methodology involving diagnosis of prostate cancer (PCa) relies on the pathology examination of prostate needle biopsies, a method with high false negative rates partly due to temporospatial, molecular, and morphological heterogeneity of prostate adenocarcinoma. It is postulated that molecular markers have a potential to assign diagnosis to a considerable portion of undetected prostate tumors. This study examines the genome-wide DNA methylation changes in PCa in search of genomic markers for the development of a diagnostic algorithm for PCa screening.

Methods

Archival PCa and normal tissues were assessed using genomic DNA methylation arrays. Differentially methylated sites and regions …

The Impact Of Blood Pressure Dipping Status On Cognition, Mobility And Cardiovascular Health In Older Adults Following An Exercise Program, Narlon Cassio Boa Sorte Silva, Michael A. Greagory, Dawn P. Gill, Cheri L. Mcgowan, Robert Petrella

Lifestyle Research Team

Objectives: To determine whether a dual-task gait and aerobic exercise intervention differentially impacted older adults with normal blood pressure (BP) dipping status (dippers) compared to those with nondipping status (nondippers).

Methods: This study was a secondary analysis involving participants (mean age = 70.3 years, 61% women) who attended a laboratory-based exercise intervention over a 6-month period (40 min/day and 3 days/week). Participants were assessed in measures of cognition, mobility, and cardiovascular health at baseline, 3, 6, and 12 months (after a 6-month no-contact follow-up).

Results: We observed improvements in cognition in both groups at 6 and 12 months, although no …

Comparison Of Two Surgical Methods For Slap Lesions, Holly Winiarczyk

Undergraduate Research Celebration 2018

No abstract provided.

A Review Of Clinical Radioprotection And Chemoprotection For Oral Mucositis., Bryan Oronsky, Sharad Goyal, Michelle M Kim, Pedro Cabrales, Michelle Lybeck, Scott Caroen, Neil Oronsky, Erica Burbano, Corey Carter, Arnold Oronsky

Radiology Faculty Publications

The first tenet of medicine, "primum non nocere" or "first, do no harm", is not always compatible with oncological interventions e.g., chemotherapy, targeted therapy and radiation, since they commonly result in significant toxicities. One of the more frequent and serious treatment-induced toxicities is mucositis and particularly oral mucositis (OM) described as inflammation, atrophy and breakdown of the mucosa or lining of the oral cavity. The sequelae of oral mucositis (OM), which include pain, odynodysphagia, dysgeusia, decreased oral intake and systemic infection, frequently require treatment delays, interruptions and discontinuations that not only negatively impact quality of life but also tumor control …

What's Happening: April 23, 2018, Maine Medical Center

What's Happening

No abstract provided.

Empowering Victims Of Sex Trafficking: Developing A Practice Of Self-Care, Samantha Foster

Theses and Graduate Projects

Sex trafficking (ST) is on the rise globally, nationally, and locally. This modern day form of slavery most often victimizes women and children, stripping them of their personal power. The traumatizing crime that is sex trafficking affects its victims physically, mentally, emotionally, and spiritually and has many negative ramifications on communities. Minnesota is leading the Nation in addressing this human rights violation by implementing and enforcing the Safe Harbor Law. Guided by concepts of Jean Watson’s Theory of Human Caring, trauma-informed care (TIC) practices, current literature support, and in cooperation with shelters like Brittany’s Place in Minnesota, nurses may utilize …

Modern Advances In 3d Bioprinting Techniques: The Organ Easy-Bake Oven, Michael Oladosu

D.U.Quark

Bioprinting is an additive tissue manufacturing process in which cells are stacked in a layer by layer process. Progress in bioprinting techniques have advanced the potential in various medical disciplines such as printed tissue, organs, and bone structures for implantation. Due to the wide array of variations in terms of application there can be a lot of confusion as to what the best method would be to print a structure. This review will describe key factors to the printing process such as bioink selection, printer configurations as well as post-print stabilization methods. Greater understanding of available technologies can dramatically improve …

Promoting Aphasia Awareness, Yvonne M. Faria, Fiona Mcnulty, Veronica C. Gonzalez, Peggy S. Conner

Publications and Research

The National Aphasia Association defines aphasia as an impairment of language, affecting the production or comprehension of speech and ability to write. This communication disorder is typically acquired after a brain injury resulting from an accident or stroke. Nearly 180,000 Americans acquire aphasia each year. Despite efforts to increase awareness about aphasia, via organizations such as the National Aphasia Association, general knowledge is still limited. In 2000 Elman and colleagues collected data on the number of news articles that mentioned the term “aphasia” and compared it to similar health conditions with comparable or lower prevalence rates. They found that these …

Integration Of Maternal Postpartum Services In Maternal And Child Health Services In Kaya Health District (Burkina Faso): An Intervention Time Trend Analysis, Danielle Yugbaré Belemsaga, Anne Goujon, Halima Tougri, Abou Coulibaly, Olivier Degomme, Els Duysburgh, Marleen Temmerman, Seni Kouanda

Obstetrics and Gynaecology, East Africa

Background: The Missed Opportunities in Maternal and Infant Health (MOMI) project aimed at reducing maternal and newborn mortality and morbidity within the year after childbirth in four sub-Saharan African countries. MOMI interventions including the integration of maternal and infant services in the postpartum (PP) period at day 6–10, week 6–8, and month 9 were implemented from September 2013 to December 2015. We hereby assess the effect of integrating maternal postpartum care (PPC) in infant immunization services in Kaya health district in Burkina Faso.

Methods: We apply a longitudinal mixed method on monthly monitoring data collected from 12 months before the …

Blood Pressure Management In The Elderly Patient Population, Karrie Fugate

Nursing Capstones

No abstract provided.

Using An Evidence-Based Tobacco Cessation Treatment Guideline Workshop To Increase Nurses’ Skill, Confidence, And Provision Of Care, Tonya Tyson

Doctor of Nursing Practice (DNP) Translational and Clinical Research Projects

Abstract Approximately 15% of adults 18 years of age or older in the United States smoke tobacco. Over 16 million people who smoke tobacco have a related disease. Since nurses comprise the largest group of health care providers in the country, they could have a big impact on client cessation efforts. Many nurses, however, feel unprepared to provide evidence-based smoking cessation counseling (SCC) per established national guidelines. The aim of this project was to provide a brief workshop providing nursing students and faculty training. The theory of planned behavior was used as a framework to measure attitudes toward providing SCC, …