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Articles 1 - 30 of 196
Full-Text Articles in Medicine and Health Sciences
Diagnostic Value Of Ultrasonography In Peroneal Neuropathy, İlkay Koray Bayrak, Ayşe Oytun Bayrak, Hande Türker, Çeti̇n Kürşad Akpinar, Necdet Bolat
Diagnostic Value Of Ultrasonography In Peroneal Neuropathy, İlkay Koray Bayrak, Ayşe Oytun Bayrak, Hande Türker, Çeti̇n Kürşad Akpinar, Necdet Bolat
Turkish Journal of Medical Sciences
Background/aim: Peroneal neuropathy at the fibular head (PNFH) is one of the most common entrapment neuropathies. Our aim in this study was to analyze the efficiency of ultrasonography in the diagnosis of PNFH. Materials and methods: The study included 15 peroneal nerves of 12 patients with PNFH and 24 peroneal nerves of 12 healthy controls. PNFH confirmation was based on clinical and electrophysiological findings. All patients and controls underwent ultrasonographic evaluations for peroneal nerves. The cross-sectional area (CSA) was measured. Echogenicity of the nerve was evaluated by comparing it with the adjacent connective tissue deep under the subcutaneous fat. Results: …
The Psychometric Evaluation Of The Turkish Version Of The Mann Assessment Of Swallowing Ability In Patients In The Early Period After Stroke, Ebru Karaca Umay, İbrahi̇m Gündoğdu, Eda Gürçay, Erhan Ari̇f Öztürk, Volkan Yilmaz, Özgür Zeli̇ha Karaahmet, Yasemi̇n Eren, Güleser Saylam, Fatma Aytül Çakci
The Psychometric Evaluation Of The Turkish Version Of The Mann Assessment Of Swallowing Ability In Patients In The Early Period After Stroke, Ebru Karaca Umay, İbrahi̇m Gündoğdu, Eda Gürçay, Erhan Ari̇f Öztürk, Volkan Yilmaz, Özgür Zeli̇ha Karaahmet, Yasemi̇n Eren, Güleser Saylam, Fatma Aytül Çakci
Turkish Journal of Medical Sciences
Background/aim: The Mann Assessment of Swallowing Ability (MASA) is an efficient tool that allows physicians to determine the alertness, cooperation, and respiration of patients, which are important factors when assessing swallowing . This study aimed to translate the MASA into Turkish (T-MASA) and to assess its reliability and validity in patients during the early period after a stroke . Materials and methods: The scale was administered to 141 patients in the early period after a stroke. For reliability, both internal consistency (Cronbach's alpha and corrected item-to-total correlations) and interrater reliability were analyzed. The procedures were scored by two blinded independent …
Determinants And Characteristics Of Tuberculosis In Liver Transplant Recipients, Ayli̇n Özgen Alpaydin, Mücahi̇t Özbi̇lgi̇n, Madina Abdullayeva, Selver Seda Mersi̇n, Tufan Egeli̇, Tarkan Ünek, Oğuz Kilinç, İbrahi̇m Kemal Astarcioğlu, Vi̇ldan Avkan Oğuz
Determinants And Characteristics Of Tuberculosis In Liver Transplant Recipients, Ayli̇n Özgen Alpaydin, Mücahi̇t Özbi̇lgi̇n, Madina Abdullayeva, Selver Seda Mersi̇n, Tufan Egeli̇, Tarkan Ünek, Oğuz Kilinç, İbrahi̇m Kemal Astarcioğlu, Vi̇ldan Avkan Oğuz
Turkish Journal of Medical Sciences
Background/aim: Solid organ transplant (SOT) recipients have increased risk of tuberculosis (TB). We aimed to investigate the prevalence and features of TB in liver transplant (LT) recipients at our transplantation canter. Materials and methods: All patients who underwent LT between January 2004 and December 2013 and whose data were accessible were included in the study. Demographic features, tuberculin skin test (TST) results, and TB prevalence were recorded. Characteristics of LT recipients who developed TB were evaluated. Results: A total of 403 patients underwent LT during this period. Mean age was 47.27 ± 11.04 years; 280 (69.47%) were males. The TST …
A Comparison Of The Effects Of Perindopril Arginine And Amlodipine On Choroidal Thickness In Patients With Primary Hypertension, Erel İçel, Hali̇l İbrahi̇m İmamoğlu, Adem Türk, Aykut İçel, Nuretti̇n Akyol
A Comparison Of The Effects Of Perindopril Arginine And Amlodipine On Choroidal Thickness In Patients With Primary Hypertension, Erel İçel, Hali̇l İbrahi̇m İmamoğlu, Adem Türk, Aykut İçel, Nuretti̇n Akyol
Turkish Journal of Medical Sciences
Background/aim: This study aimed to investigate the effects of two different medical treatment options on choroidal thickness (CT) in patients with primary hypertension. Materials and methods: Forty newly diagnosed primary hypertension patients and 21 healthy volunteers were included. The patients were randomly divided into two subgroups. Group I started on perindopril arginine and Group II started on amlodipine. Submacular CT using optical coherence tomography (OCT) was measured before treatment and at the third and sixth months after treatment. Results: Initial mean arterial pressure (MAP) values in Groups I and II and the control group were 113.4, 109.8, and 89.4 mmHg, …
The Histopathological Effects Of Calcium Triglyceride Bone Cement Andchitosan On The Healing Of Experimental Bone Defects, Levent Uslucan, Berkem Atalay, Cüneyt Korhan Oral, Mustafa Sami̇ Yildirim, Abdulkadi̇r Burak Çankaya
The Histopathological Effects Of Calcium Triglyceride Bone Cement Andchitosan On The Healing Of Experimental Bone Defects, Levent Uslucan, Berkem Atalay, Cüneyt Korhan Oral, Mustafa Sami̇ Yildirim, Abdulkadi̇r Burak Çankaya
Turkish Journal of Medical Sciences
Background/aim: This study evaluated the histopathological effects of two different bone grafts, calcium triglyceride bone cement (CTBC) and chitosan, on the healing of experimental bone defects. Materials and methods: Ninety-two Sprague Dawley male rats, with a weight of 240 ± 20 g, were used. Two experimental groups that consisted of 64 rats were divided into four subgroups due to the sacrification days, which were 7, 14, 30, and 60. After creating an 8-mm- long and 1-mm-wide cortico-cancellous bone defect in the right tibia of each rat, CTBC and chitosan were applied to the bone defects. In the main group, after …
Vascular Responses Of Aortic, Renal, And Uterine Arteries In Suramin-Induced Preeclampsia-Like Syndrome In Rats, Sebi̇le Güler Çeki̇ç, Edi̇p Güvenç Çeki̇ç, Di̇lek Baydar, Meral Tuncer, Güray Soydan
Vascular Responses Of Aortic, Renal, And Uterine Arteries In Suramin-Induced Preeclampsia-Like Syndrome In Rats, Sebi̇le Güler Çeki̇ç, Edi̇p Güvenç Çeki̇ç, Di̇lek Baydar, Meral Tuncer, Güray Soydan
Turkish Journal of Medical Sciences
Background/aim: Suramin is a potent angiogenesis inhibitor in rodents and attenuates placental development in rat pregnancy. We aimed to produce preeclampsia-like syndrome by suramin administration in rats and to investigate the functional responses in aortic, renal, and uterine arteries. Materials and methods: Pregnant and nonpregnant wistar rats received suramin (100 mg/kg, intraperitoneal) or equal volume of saline on days 10 and 11. Blood pressures of rats were observed daily. On the day 20, rats were executed. Protein levels in urine were measured and fetuses, placentas, and kidneys were weighted and evaluated. Thoracic aorta, renal, and uterine arteries were removed for …
Real-Time Pcr Using High-Resolution Melting Analysis Technology For Diagnosis Of Leishmania And Determination Of Types Of Clinical Samples, Serhat Si̇rekbasan, Erdal Polat
Real-Time Pcr Using High-Resolution Melting Analysis Technology For Diagnosis Of Leishmania And Determination Of Types Of Clinical Samples, Serhat Si̇rekbasan, Erdal Polat
Turkish Journal of Medical Sciences
Background/aim: Leishmaniasis is a disease group carried by Phlebotomus and Lutzomyia sand flies infected with Leishmania and is mostly observed in rural areas. In this study, using high-resolution melting analysis (HRMA), we aim to identify the active types of leishmaniasis, which are inadequately identified by classical methods. Materials and methods: Samples of 85 patients were examined in the study. Six of the patients were suspected of having visceral leishmaniasis (VL) and 79 cutaneous leishmaniasis (CL). The slides prepared from the samples were stained with Giemsa stain and examined under a light microscope. The results were compared with those determined in …
The Effects Of Preadministration Of Local Anesthetic On Pulsed Radiofrequency, Tüli̇n Arici, Mustafa Kurçaloğlu, İdri̇s Şevki̇ Köken, Bora Uzuner, Can Eyi̇gör, Meltem Uyar
The Effects Of Preadministration Of Local Anesthetic On Pulsed Radiofrequency, Tüli̇n Arici, Mustafa Kurçaloğlu, İdri̇s Şevki̇ Köken, Bora Uzuner, Can Eyi̇gör, Meltem Uyar
Turkish Journal of Medical Sciences
Background/aim: Pulsed radiofrequency (PRF) has been reported to be a safe and reliable method for the management of a variety of chronic pain syndromes. It is not known whether the preadministration of local anesthetic increases the size of the electrical field. We revealed the effects of administering local anesthetic on PRF and investigated whether they were related to local anesthetic or fluid effects. Materials and methods: Group 1 (n = 18) received PRF to the suprascapular nerve with 1 mL of bupivacaine, group 2 (n = 20) received PRF with 1 mL of physiological saline solution, and group 3 (n …
Is Thermal Balloon Ablation In Women With Previous Cesarean Delivery Successful?, Zinatossadat Bouzari, Shahla Yazdani, Mojgan Naeimi Rad, Ali Bijani
Is Thermal Balloon Ablation In Women With Previous Cesarean Delivery Successful?, Zinatossadat Bouzari, Shahla Yazdani, Mojgan Naeimi Rad, Ali Bijani
Turkish Journal of Medical Sciences
Background/aim: Endometrial ablation is used to treat heavy menstrual bleeding in women who do not respond to standard therapy. is study aimed to compare treatment success in women with previous cesarean delivery and vaginal delivery who were subjected to thermal balloon ablation. Materials and methods: This cohort study enrolled women with symptoms of heavy menstrual bleeding who had major health problems and were considered as high-risk patients for hysterectomy. Patients were divided into two groups, vaginal delivery and cesarean section (C-section). ermal balloon ablation was performed under general or regional anesthesia on days 3?5 of the menstrual cycle. Treatment success …
The Impact Of Visit-To-Visit Systolic Blood Pressure Variability On Residual Renal Function And Left Ventricular Hypertrophy In Peritoneal Dialysis Patients, Jun Ping Tian, Hong Wang, Xin Kui Tian, Feng He Du, Tao Wang
The Impact Of Visit-To-Visit Systolic Blood Pressure Variability On Residual Renal Function And Left Ventricular Hypertrophy In Peritoneal Dialysis Patients, Jun Ping Tian, Hong Wang, Xin Kui Tian, Feng He Du, Tao Wang
Turkish Journal of Medical Sciences
Background/aim: Blood pressure (BP) variability is more closely associated with adverse outcomes than 'usual' BP in the general population. Residual renal function (RRF) and left ventricular hypertrophy (LVH) are thought to be predictors of poor outcome in dialysis patients. However, only a few studies have focused on BP variation and its link to RRF, LVH, and outcome in peritoneal dialysis (PD) patients. therefore, we aimed to explore the e ect of visit-to-visit BP variability on RRF and LVH in continuous ambulatory PD (CAPD) patients. Materials and methods: We performed an observational study that included all prevalent PD patients between 1 …
Low Levels Of Vitamin D Are Associated With Nosocomial Infections But Not With Short-Term Mortality In Critically Ill Patients, Işil Köse Güldoğan, Çi̇ler Zi̇nci̇rci̇oğlu, Hüseyi̇n Özkarakaş, Meltem Çakmak, Gürsel Ersan, Lütfi̇ye Kuzucu, Şükran Köse, Ni̇met Şenoğlu
Low Levels Of Vitamin D Are Associated With Nosocomial Infections But Not With Short-Term Mortality In Critically Ill Patients, Işil Köse Güldoğan, Çi̇ler Zi̇nci̇rci̇oğlu, Hüseyi̇n Özkarakaş, Meltem Çakmak, Gürsel Ersan, Lütfi̇ye Kuzucu, Şükran Köse, Ni̇met Şenoğlu
Turkish Journal of Medical Sciences
Background/aim: A prospective observational study was conducted to determine the relationship between vitamin D de ciency and nosocomial infections among intensive care unit (ICU) patients. Materials and methods: Demographic data, season of admission, vitamin D levels at admission, premorbid lifestyle scores, comorbid conditions, and admission diagnosis were recorded in 306 ICU patients. Infections that developed at least 48 h a er admission to the ICU were the primary outcome, and ICU, hospital, and 1-year mortality were the secondary outcomes. Infections were evaluated for 28 days, and for the entire duration of ICU stay independently. Multiple logistic regression analysis was performed …
Cpr-Related Thoracic Injuries: Comparison Of Cpr Guidelines Between 2010 And 2015, Kaan Yusufoğlu, Mehmet Özgür Erdoğan, İsmai̇l Tayfur, Mustafa Ahmet Afacan, Şahi̇n Çolak
Cpr-Related Thoracic Injuries: Comparison Of Cpr Guidelines Between 2010 And 2015, Kaan Yusufoğlu, Mehmet Özgür Erdoğan, İsmai̇l Tayfur, Mustafa Ahmet Afacan, Şahi̇n Çolak
Turkish Journal of Medical Sciences
Background/aim: This study aimed to evaluate traumatic thorax complications in post-CPR patients and to investigate whether or not there has been a decrease in these complications since the adoption of current chest compression recommendations. Materials and methods: Post-CPR patients with return of spontaneous circulation (ROSC) were admitted between January 2014 and January 2016 were analyzed retrospectively. Patients admitted to the ED in 2014 were resuscitated according to 2010 AHA CPR guidelines, while those admitted to the ED in 2015 were resuscitated according to current ERC CPR guidelines. Results: The study population comprised 48 male and 35 female patients. Of the …
Retinopathy Of Prematurity In Extremely Premature Infants: Multiplebirths Versus Single Births, İkbal Seza Petri̇çli̇, Caner Kara, Ni̇hal Demi̇rel, Di̇lek Ulubaş Işik, Ahmet Yağmur Baş
Retinopathy Of Prematurity In Extremely Premature Infants: Multiplebirths Versus Single Births, İkbal Seza Petri̇çli̇, Caner Kara, Ni̇hal Demi̇rel, Di̇lek Ulubaş Işik, Ahmet Yağmur Baş
Turkish Journal of Medical Sciences
Background/aim: This study aimed to compare the incidence of any stage of retinopathy of prematurity (ROP) and type 1 ROP between extremely preterm multiple- and single-birth infants. Materials and methods: In this retrospective study, we included extremely preterm infants who were ≤27 weeks of gestational age at birth. The screened infants were divided into two groups: single and multiple births. The incidence of any stage of ROP and type 1 ROP was compared between the groups. Results: This study included 301 infants; 225 were in the single-birth group and 76 were in multiple-birth group. The incidences of any stage of …
Prognostic Value Of Interferon-Gamma, Interleukin-6, And Tumor Necrosis Factor-Alpha In The Radiation Response Of Patients Diagnosed With Locally Advanced Non-Small-Cell Lung Cancer And Glioblastoma Multiforme, Çi̇ğdem Damla Deni̇z, Mehmet Gürbi̇lek, Mehmet Koç
Prognostic Value Of Interferon-Gamma, Interleukin-6, And Tumor Necrosis Factor-Alpha In The Radiation Response Of Patients Diagnosed With Locally Advanced Non-Small-Cell Lung Cancer And Glioblastoma Multiforme, Çi̇ğdem Damla Deni̇z, Mehmet Gürbi̇lek, Mehmet Koç
Turkish Journal of Medical Sciences
Background/aim: This study aimed to investigate the effect of chemoradiotherapy (CRT) on interferon-gamma (IFN-γ), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α), which are critical markers of the clinical radiation response of patients with locally advanced non-small-cell lung cancer (NSCLC) and glioblastoma multiforme (GBM). Materials and methods: Thirty patients who were treated with CRT and 20 healthy controls were prospectively evaluated. Circulating levels of cytokines were measured by enzyme-linked immunosorbent assay procedure. Post-CRT and pre-CRT levels were compared. Results: Post-CRT, TNF-α and IFN-γ levels were significantly lower than pre-CRT levels in the NSCLC and GBM groups, respectively. The statistical analysis did …
The Role Of Apoptosis And The Effect Of Epidermal Growth Factor On Proapoptotic Bnip 3 In An Experimental Rat Priapism Model, Osman Barut, Ahmet Karakeçi̇, Tunç Ozan, Fati̇h Firdolaş, Neci̇p Pi̇ri̇nççi̇, İrfan Orhan
The Role Of Apoptosis And The Effect Of Epidermal Growth Factor On Proapoptotic Bnip 3 In An Experimental Rat Priapism Model, Osman Barut, Ahmet Karakeçi̇, Tunç Ozan, Fati̇h Firdolaş, Neci̇p Pi̇ri̇nççi̇, İrfan Orhan
Turkish Journal of Medical Sciences
Background/aim: This study aimed to investigate the effects of apoptosis-inducing Bcl-2/adenovirus E1B 19 kDa-interacting protein 3 (BNIP 3) and antiapoptotic epidermal growth factor (EGF) on the pathophysiology of experimental low-flow priapism. Materials and methods: Twenty-four adult Sprague-Dawley rats were divided into four equal groups. Group I was the control group. Ischemic priapism was induced for 4 h in Group II rats. In Group III, intraperitoneal EGF at 10 µg/kg was given for 7 days before induction of ischemic priapism for 4 h. In Group IV, intraperitoneal EGF at 20 µg/kg was given for 7 days before induction of ischemic priapism …
Multitarget Therapy Versus Intravenous Cyclophosphamide In The Induction Treatment Of Lupus Nephritis: A Metaanalysis Of Randomized Controlled Trials, Jin Deng, Lei Luo, Lin Zhu, Huan Xie, Hong-Ping Xie
Multitarget Therapy Versus Intravenous Cyclophosphamide In The Induction Treatment Of Lupus Nephritis: A Metaanalysis Of Randomized Controlled Trials, Jin Deng, Lei Luo, Lin Zhu, Huan Xie, Hong-Ping Xie
Turkish Journal of Medical Sciences
Background/aim: Multitarget therapy for lupus nephritis (LN) remains in its exploratory phrase and the recent evidence is insufficient. This study aimed to evaluate the efficacy and safety of mycophenolate mofetil (MMF), tacrolimus (TAC), and steroids (multitarget therapy) versus intravenous cyclophosphamide (IVC) and steroids in induction treatment of LN. Materials and methods: We searched for randomized controlled trials of MMF plus TAC versus IVC in LN using PubMed, EMBASE, the Cochrane Central Register of Controlled Trials, the China Biology Medicine Database, and the China National Knowledge Infrastructure Database. We assessed the retrieved citations and selected studies according to predefined inclusion and …
Phenotypic Spectrum Of Charge Syndrome Based On Clinical Characteristics, Özge Aksel Kiliçarslan, Esra Ataman, Semra Gürsoy, Fi̇li̇z Hazan, Nadi̇de Cemre Randa, Tufan Çankaya, Murat Derya Erçal, Ayfer Ülgenalp, Özlem Gi̇ray Bozkaya
Phenotypic Spectrum Of Charge Syndrome Based On Clinical Characteristics, Özge Aksel Kiliçarslan, Esra Ataman, Semra Gürsoy, Fi̇li̇z Hazan, Nadi̇de Cemre Randa, Tufan Çankaya, Murat Derya Erçal, Ayfer Ülgenalp, Özlem Gi̇ray Bozkaya
Turkish Journal of Medical Sciences
Background/aim: CHARGE syndrome is a rare autosomal dominant disease with multiple congenital anomalies and cognitive impairment, which is caused by mutations in the CHD7 gene. This study aimed to disclose the mild end of the phenotypic spectrum of CHARGE syndrome, which has a highly variable expressivity. Materials and methods: Twenty-one patients who had at least one of the major symptoms of CHARGE syndrome (coloboma, choanal atresia, characteristic ear anomalies, semicircular canal hypoplasia, and cranial nerve anomalies) were included in the study. All patients were tested for karyotype analysis and CHD7 gene mutation/deletion. Results: In the study population, 6 different mutations …
Is Nrem-Predominant Obstructive Sleep Apnea Syndrome A Different Clinical Entity?, Mehmet İlker Yön, Oğuz Köktürk
Is Nrem-Predominant Obstructive Sleep Apnea Syndrome A Different Clinical Entity?, Mehmet İlker Yön, Oğuz Köktürk
Turkish Journal of Medical Sciences
Background/aim: This study aimed to evaluate whether NREM-predominant obstructive sleep apnea syndrome (OSAS) patients (NREM AHI < REM AHI) have distinct clinical and polysomnographic features compared to REM-predominant OSAS patients (REM AHI > NREM AHI). Materials and methods: A total of 342 patients (93 females and 249 males) who were admitted to the Sleep Disorders Unit at the Gazi University Faculty of Medicine and underwent polysomnography between January 2011 and April 2016 were retrospectively reviewed. Patient data, symptoms related to OSAS, Epworth Sleepiness Scale (ESS) scores, and polysomnographic findings were recorded. The patients were divided into two groups according to the apnea-hypopnea index (AHI) as patients with NREM-predominant OSAS and patients with REM-predominant OSAS. Results: The total …
Distribution Of Lymphomas In Turkey: Data Of 4239 Cases From A Singleinstitution Using The Who Classification, Arzu Sağlam, Ece Esi̇n, Mutlu Hayran, Bariş Boyraz, Ayşegül Üner
Distribution Of Lymphomas In Turkey: Data Of 4239 Cases From A Singleinstitution Using The Who Classification, Arzu Sağlam, Ece Esi̇n, Mutlu Hayran, Bariş Boyraz, Ayşegül Üner
Turkish Journal of Medical Sciences
Background/aim: Lymphoma cases diagnosed at one of the largest tertiary reference centers in Turkey were reviewed and findings were compared to those reported from other regions of the world. Materials and methods: Lymphomas diagnosed between 2000 and 2017 in the pathology laboratory of Hacettepe University were identified. A total of 4239 cases were analyzed. The WHO 2008 classification was used. Results: Hodgkin lymphomas accounted for almost 20% of cases. T-cell lymphomas were much more frequent (23% of our non- Hodgkin lymphoma (NHL) cases) in comparison to all other regions of the world. The reason for this difference was the high …
The Diagnostic Value Of Elastography Score And Strain Index For The Evaluation Of Thyroidmicronodules, Erman Çakal, Meli̇a Karaköse, İlknur Öztürk Ünsal, Mustafa Şahi̇n, Beki̇r Uçan, Mustafa Özbek
The Diagnostic Value Of Elastography Score And Strain Index For The Evaluation Of Thyroidmicronodules, Erman Çakal, Meli̇a Karaköse, İlknur Öztürk Ünsal, Mustafa Şahi̇n, Beki̇r Uçan, Mustafa Özbek
Turkish Journal of Medical Sciences
Background/aim: In the general population, the frequency of thyroid micronodules is increasing, and the prevalence of malignancy is higher for such nodules. Ultrasonography findings of these nodules are neither specific nor sensitive. The aim of this study was to investigate the diagnostic value of elastography in patients with thyroid micronodules. Materials and methods: A total of 224 patients with thyroid micronodules were recruited in this prospective study. All patients underwent a thyroid fine-needle aspiration biopsy. Elastography scores (ESs) and strain indexes (SIs) were measured with real-time ultrasound elastography. Results: Malignant micronodules had higher ES and SI values than those of …
The Role Of Melatonin In Preventing Ovarian Tissue Damage In Rats Exposed To Magnetic Fields, Zahi̇de Küçük, Uğurkan Erkayiran, Muzaffer Çaydere, Damla Kayalp, Deni̇z Karçaaltincaba
The Role Of Melatonin In Preventing Ovarian Tissue Damage In Rats Exposed To Magnetic Fields, Zahi̇de Küçük, Uğurkan Erkayiran, Muzaffer Çaydere, Damla Kayalp, Deni̇z Karçaaltincaba
Turkish Journal of Medical Sciences
Objectives: We observed the efficacy of melatonin in preventing ovarian tissue damage in rats exposed to magnetic fields. Materials and methods: Forty rats were divided into four treatment groups: Group 1, control group (n = 10); Group 2, melatonin administration only (n = 10); Group 3, magnetic field exposure only (n = 10); Group 4, magnetic field exposure with melatonin administration (n = 10). The magnetic field was applied at a dose of 20 μT for 30 min/day for 10 days. Melatonin was orally administered at a dose of 10 mg/kg. We evaluated follicle count, degree of fibrosis, amount of …
Recent Therapeutic Developments In Spinal Muscular Atrophy, Gamze Bora, Ayşe Yeşbek-Kaymaz, Can Ebru Beki̇rcan-Kurt, Vi̇ldan Göknur Hali̇loğlu, Haluk Aydin Topaloğlu, Hayat Erdem-Yurter, Sevi̇m Erdem-Özdamar
Recent Therapeutic Developments In Spinal Muscular Atrophy, Gamze Bora, Ayşe Yeşbek-Kaymaz, Can Ebru Beki̇rcan-Kurt, Vi̇ldan Göknur Hali̇loğlu, Haluk Aydin Topaloğlu, Hayat Erdem-Yurter, Sevi̇m Erdem-Özdamar
Turkish Journal of Medical Sciences
Proximal spinal muscular atrophy (SMA) is an inherited neurodegenerative disease with a heterogeneous clinical phenotype. Although there is no cure for SMA, several strategies are currently being developed. In this review, we summarize the ongoing clinical trials and molecular mechanisms of successful approaches to SMA treatment.
Reliability And Validity Of The Turkish Nose Obstruction Symptom Evaluation (Nose) Scale, Serdar Karahatay, Hamdi̇ Taşli, Ömer Karakoç, Ümi̇t Aydin, Türker Türker
Reliability And Validity Of The Turkish Nose Obstruction Symptom Evaluation (Nose) Scale, Serdar Karahatay, Hamdi̇ Taşli, Ömer Karakoç, Ümi̇t Aydin, Türker Türker
Turkish Journal of Medical Sciences
Background/aim: e aim of this study was to validate the Turkish Nasal Obstruction Symptom Evaluation (T-NOSE) scale. Materials and methods: e NOSE scale was translated into Turkish. A prospective study was conducted involving adult subjects with nasal obstruction and a control group. e patients were divided into three groups, namely nasal septum deviation (NSD), septoplasty, and control groups. Internal consistency, test-retest reliability, validity, responsiveness, and the magnitude of the e ect of surgery were all investigated. Results: In total, 253 subjects were enrolled in the study. Cronbach?s alpha was 0.938 and 0.942 upon test and retest, respectively, which proved good …
Emotion Regulation And Premedication Success Relationship In Children Who Underwent General Anesthesia, Aslihan Aykut, Berri̇n Işik
Emotion Regulation And Premedication Success Relationship In Children Who Underwent General Anesthesia, Aslihan Aykut, Berri̇n Işik
Turkish Journal of Medical Sciences
Background/aim: is study aims to investigate the relationship between emotion regulation characteristics and the e cacy of midazolam premedication. Materials and methods: Sixty-three children, aged 3 to 8 years old, with tonsillectomy and/or adenoidectomy and taking premedication with midazolam (Group 2) or without premedication (Group 1), were included in this study. e behavioral and emotional status of the children was evaluated with the Conners Parent Rating Scale-48 (CPRS-48) and Emotion Regulation Checklist (ERC). Age, sex, body weight, response to intravenous (IV) cannulation and mask, hemodynamic data, preoperative sedation scores [Wilton Sedation Scale (WSS)], postoperative pain intensity [Objective Pain Scale (OPS)], …
Risk Factor Assessment For Breast Cancer In North Cyprus: A Comprehensive Case-Control Study Of Turkish Cypriot Women, Ruqiya Pervaiz, Özgür Tosun, Hasan Besim, Nedi̇me Serakinci
Risk Factor Assessment For Breast Cancer In North Cyprus: A Comprehensive Case-Control Study Of Turkish Cypriot Women, Ruqiya Pervaiz, Özgür Tosun, Hasan Besim, Nedi̇me Serakinci
Turkish Journal of Medical Sciences
Background/aim: This case-control study aims to assess the strength of associations between reproductive, lifestyle, sociodemographic, and dietary factors as well as other potential breast cancer risks and breast cancer (BC) in a North Cyprus population. Materials and methods: The study includes 408 BC patients and 412 age-matched controls recruited from Near East Hospital and Dr. Burhan Nalbantoglu State Hospital in North Cyprus. Information regarding clinical and epidemiological characteristics was collected through a standardized interview. Age-adjusted odds ratios (ORs) and 95% con dence intervals (CIs) were calculated by logistic regression before and a er adjusting for the potential confounders. Results: In …
Pooled Analysis Of 163 Published Tuberculous Peritonitis Cases From Turkey, Bedi̇a Mutay Suntur, Feri̇t Kuşcu
Pooled Analysis Of 163 Published Tuberculous Peritonitis Cases From Turkey, Bedi̇a Mutay Suntur, Feri̇t Kuşcu
Turkish Journal of Medical Sciences
Background/aim: Tuberculous peritonitis may be di cult to diagnose due to its insidious and variable clinical manifestations as well as characteristics similar to malignancy. In this study, case reports from Turkey over the last 10 years were reviewed systematically using pooled analysis. Materials and methods: irty-four suitable articles were found and 163 tuberculous peritonitis cases were included in the study. Results: e mean age was 34.1 years (17?79 years), and 146 (98.6%) of the patients were female and 17 (10.4%) were male. e most common complaints of these patients were abdominal pain (77.4%) and abdominal distention (73.5%). Ascites in the …
Hand Infection In Patients With Diabetes: A Series Of 17 Cases And A Pooled Analysis Of The Literature, Anil Murat Öztürk, Serhat Uysal, Ilgin Yildirim Şi̇mşi̇r, Hi̇lmi̇ Güngör, Meltem Taşbakan
Hand Infection In Patients With Diabetes: A Series Of 17 Cases And A Pooled Analysis Of The Literature, Anil Murat Öztürk, Serhat Uysal, Ilgin Yildirim Şi̇mşi̇r, Hi̇lmi̇ Güngör, Meltem Taşbakan
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to report the clinical characteristics and the treatment outcomes of hand infections in diabetic patients and to review the literature. Materials and methods: The medical records of 17 patients with diabetic hand infections admitted to the Diabetic Foot Care Center of two di erent clinics from January 2012 to October 2017 were reviewed. To perform the pooled analysis, published series (32 studies) were searched in two international databases (www.scopus.com and www.pubmed.com). Results: Of the 17 patients (mean age 61.7 ± 8.5 years), 8 (47.1%) were female. All cases were type 2 diabetes mellitus. …
The Relationship Between Vitamin D Deficiency And Erythrocyte Sedimentation Rate In Patients With Diabetes, Tezcan Kaya, Emi̇ne Ülkü Akçay, Zeynep Ertürk, Hasan Ergenç, Ali̇ Tamer
The Relationship Between Vitamin D Deficiency And Erythrocyte Sedimentation Rate In Patients With Diabetes, Tezcan Kaya, Emi̇ne Ülkü Akçay, Zeynep Ertürk, Hasan Ergenç, Ali̇ Tamer
Turkish Journal of Medical Sciences
Background/aim: Vitamin D deficiency in diabetic patients has been shown to be associated with some in ammatory markers. However, its relationship with erythrocyte sedimentation rate (ESR) is still unknown. The aim of this study was to investigate the relationship between vitamin D deficiency and ESR in patients with type 2 diabetes mellitus (T2DM). Materials and methods: This cross-sectional study was conducted with 294 consecutive patients with T2DM. Serum levels of 25-hydroxyvitamin D, glycemic parameters, lipids, ESR, and C-reactive protein were measured. Patients were evaluated according to 25-hydroxyvitamin D levels as having vitamin D deficiency, vitamin D insuficiency, and vitamin D …
The Relation Between Isolated Micropenis In Childhood With Cag And Ggn Repeat Polymorphisms In The Androgen Receptor Gene, Esra Tuğ, Sezen Günteki̇n Ergün, Mehmet Ali̇ Ergün, Fatma Ni̇hal Di̇lek, Ferda Emri̇ye Perçi̇n
The Relation Between Isolated Micropenis In Childhood With Cag And Ggn Repeat Polymorphisms In The Androgen Receptor Gene, Esra Tuğ, Sezen Günteki̇n Ergün, Mehmet Ali̇ Ergün, Fatma Ni̇hal Di̇lek, Ferda Emri̇ye Perçi̇n
Turkish Journal of Medical Sciences
Background/aim: In micropenis cases accompanied by external genital abnormalities such as hypospadias and cryptorchidism, infertility and spermatogenic failures have been reported to correlate with androgen receptor (AR) gene CAG and GGN repeat polymorphisms. While there is one study on isolated micropenis and CAG repeats, no study related to GGN repeats has been reported. We investigated the relation between CAG and GGN repeats in the AR gene with development of penis length in boys with isolated micropenis. Materials and methods: A total of 24 Turkish boys with isolated micropenis (
A Simplified Cell Culture Model For Research On Intestinal Inflammation, Ayşe Erol, Si̇bel Ti̇ryaki̇, Mustafa Orkan Ergün
A Simplified Cell Culture Model For Research On Intestinal Inflammation, Ayşe Erol, Si̇bel Ti̇ryaki̇, Mustafa Orkan Ergün
Turkish Journal of Medical Sciences
Background/aim: e aim of this study was to combine some easy and economical de ned methods and constitute a comprehensive cell culture model to use in the bowel diseases characterized by in ammation. Materials and methods: Induction of inflammation was performed using lipopolysaccharide (LPS) or a cytokine mixture (TNF-?: 10 ng/mL; IFN-?: 100 ng/mL; IL-1ß: 1 ng/mL). IEC-6 cells were grown to con uence and serum-starved, wounds were constituted, and progress of cell migration into the wounds was photographed at 0, 2, 4, 6, 8, 10, 12, and 24 h in the presence or absence of an in ammatory environment. …