Medicine and Health Sciences Commons^™

Binding An Event To Its Source At Encoding Improves Children's Source Monitoring, Kim Roberts, Angela Evans, Sara Duncanson

Psychology Faculty Publications

Children learn information from a variety of sources and often remember the content but forget the source. While the majority of research has focused on retrieval mechanisms for such difficulties, the present investigation examines whether the way in which sources are encoded influences future source monitoring. In Study 1, 86 children aged 3 to 8 years participated in two photography sessions on different days. Children were randomly assigned to either the Difference condition (they were asked to pay attention to differences between the two events), the Memory control condition (asked to pay attention with no reference to differences), or the …

Challenges Facing East Asian Immigrant Children In Sexual Abuse Cases, Kim Roberts, Hongyuan Qi, Huan Zhang

Psychology Faculty Publications

Immigrants from East Asia make up 14.21% of the total number of immigrants in Canada. These families face many challenges as they acculturate to North America but, sadly, some of these children may be at risk for sexual abuse. In this position paper, we outline the ways in which East Asian children are at a particular disadvantage when considering prosecution of those who perpetrate abuse compared to Western non-immigrant children. We focus specifically on two areas of concern: 1) Cultural differences that can impact the disclosure of sexual abuse; and, 2) Language differences which reduce the chances that perpetrators will …

Narratives Of Resistance: (Re) Telling The Story Of The Hiv/Aids Movement – Because The Lives And Legacies Of Black, Indigenous, And People Of Colour Communities Depend On It, Ciann L. Wilson, Sarah Flicker, Jean-Paul Restoule, Ellis Furman

Psychology Faculty Publications

Centering the narratives of the intersectional struggles within the HIV movement for Indigenous sovereignty, Black and People of Colour liberation, and LGBTQ rights tirelessly fought for by Black, Indigenous, and People of Colour communities legitimates their lives and legacies within the movement; and the relevance of a focused response to the HIV epidemic that continues to wreak devastation in these communities. The recent political push for a post-HIV era solely centers the realities of middle-class white, gay men and has genocidal implications for Black, Indigenous, and People of Colour communities.

Virginia Dental Journal (Vol. 93, No. 3, 2016)

Virginia Dental Journal

No abstract provided.

Virginia Dental Journal (Vol. 93, No. 1, 2016)

Virginia Dental Journal

No abstract provided.

Ω-Amidase: An Underappreciated, But Important Enzyme In L-Glutamine And L-Asparagine Metabolism; Relevance To Sulfur And Nitrogen Metabolism, Tumor Biology And Hyperammonemic Diseases, Arthur J. Cooper, Yevgeniya I. Shurubor, Thambi Dorai, John T. Pinto, Elena P. Isakova, Yulia I. Deryabina, Travis T. Denton, Boris F. Krasnikov

NYMC Faculty Publications

In mammals, two major routes exist for the metabolic conversion of L-glutamine to α-ketoglutarate. The most widely studied pathway involves the hydrolysis of L-glutamine to L-glutamate catalyzed by glutaminases, followed by the conversion of L-glutamate to α-ketoglutarate by the action of an L-glutamate-linked aminotransferase or via the glutamate dehydrogenase reaction. However, another major pathway exists in mammals for the conversion of L-glutamine to α-ketoglutarate (the glutaminase II pathway) in which L-glutamine is first transaminated to α-ketoglutaramate (KGM) followed by hydrolysis of KGM to α-ketoglutarate and ammonia catalyzed by an amidase known as ω-amidase. In mammals, the glutaminase II pathway is …

Burnout’S Prevalence Estimations: A House Of Cards?, Renzo Bianchi, Irvin Sam Schonfeld, Eric Laurent

Publications and Research

Elmariah et al. (2016) found that 65% of the internal medicine residents who were assessed suffered from burnout. We have 3 concerns about the conclusion. First, the authors used a cutoff score on a burnout measure that is problematic because (a) it is devoid of theoretical or clinical grounding and (b) burnout items were formatted in an unorthodox manner, and (c) including residents who responded "neutral" to a symptom item among those identified as burned out. Second, the authors identified as burned out residents who worked on the night float rotation although the data suggest otherwise. Third information on symptom …

On The Dead End Of Current Research On Burnout's Prevalence, Renzo Bianchi, Irvin Sam Schonfeld, Eric Laurent

Publications and Research

Dimou et al. (2016) concluded that >50% of surgeons experience burnout. For three reasons, we think that such conclusions are unwarranted. First, there are no consensual or binding diagnostic criteria for burnout. Second, recent research (e.g., Bianchi, Schonfeld, & Laurent, 2015) suggests that burnout is actually a depressive syndrome. Finally, we note that researchers’ recommendations about stress-reducing organizational changes often remain incantatory because they insufficiently consider the economic issues and macrosocial power relationships that can hamper the recommendations’ implementation. Current practices in burnout research have led to an accumulation of results, the clinical meaning of which is obscure.

Burnout-Depression Overlap: A Study Of New Zealand Schoolteachers, Renzo Bianchi, Irvin Sam Schonfeld, Eric Mayor, Eric Laurent

Publications and Research

We examined the overlap of burnout with depression in a sample of 184 New Zealand schoolteachers. Burnout and depressive symptoms were strongly correlated with each other (r = .73; disattenuated correlation: .82) and moderately correlated with dysfunctional attitudes, ruminative responses, and pessimistic attributions. All the participants with high frequencies of burnout symptoms were identified as clinically depressed. Suicidal ideation was reported by 36% of those participants. Three groups of teachers emerged from a two-step cluster analysis: “low burnout-depression,” “medium burnout-depression,” and “high burnout-depression.” The correlation between the affective-cognitive and somatic symptoms of depression was similar in strength to the burnout-depression …

Combining Body Mass And Shape Indices In Clinical Practice, Jesse C. Krakauer, Nir Y. Krakauer

Publications and Research

We present preliminary clinical experience with combined consideration of the commonly used BMI (body mass index) and the newly developed ABSI (a body shape index) using a point of care anthropometric calculator for comparisons of index values and associated relative risks to population normals. In a series of 282 patients, BMI and ABSI were close to being independently distributed, supporting the value of considering both indices. Three selected cases illustrate scenarios where assessment of ABSI together with BMI could inform patient care and counseling. These data suggest that combined assessment of BMI and ABSI may prove useful in clinical practice.

Evolution Of Physician-Centric Business Models Under The Patient Protection And Affordable Care Act, Tanya Nix, Lynn Szostek

International Journal of Applied Management and Technology

For decades, the cost of medical care in the United States has increased exponentially. United States citizens spend twice as much as their European counterparts on medical care. Congress enacted the Patient Protection and Affordable Care Act (PPACA) to ensure affordable healthcare to the citizens of the United States. PPACA legislation is creating a new paradigm in healthcare delivery and provider business models. The purpose of this case study was to explore physicians’ perspectives regarding physician-centric business models evolving under the requirements of the PPACA legislation. Data were gathered through semistructured interviews and questionnaires with a purposive sample of 75 …

Cognitive, Psychiatric, And Neuropathological Manifestations Of Repetitive Mild Traumatic Brain Injury, Denise Briggs

Wayne State University Dissertations

Millions of athletes participate in contact sports that involve repeated head impacts (e.g., football, ice hockey, boxing), often from a very young age, and it is feared that subsequent impacts can synergize with previous ones so that their effects on the brain become magnified. Repetitive mild traumatic brain injury (rmTBI) has been linked to the development of chronic traumatic encephalopathy (CTE). The neurodegeneration accompanying CTE occurs over many years following repeated head impacts and is characterized by progressive brain atrophy, accumulation of hyper-phosphorylated tau and aggregates of TDP-43, myelinated axonopathy, neuroinflammation and degeneration of white matter tracts. The relationship between …

An Analysis Of Virtual Place Learning/Navigation In Children And Young Adults Prenatally Exposed To Alcohol, Neil Christopher Dodge

Wayne State University Dissertations

Fetal alcohol spectrum disorder refers to the spectrum of disorders resulting from prenatal alcohol exposure and is the leading cause of preventable mental retardation. Rodent studies have found that prenatal alcohol exposure impairs performance on the Morris water maze. This task requires the rodent to use distal room cues to locate a hidden platform in a pool of opaque water. Successful performance on this task is dependent upon hippocampal function. Rodents prenatally exposed to alcohol are impaired on the Morris water maze and show damage to hippocampal neurons. A human analogue of the Morris water maze, the virtual water maze …

Childhood Trauma And Emotion Processing Neurocircuitry, Hilary A. Marusak

Wayne State University Dissertations

Childhood trauma is one of the strongest risk factors for a range of common and debilitating neuropsychiatric disorders, including anxiety, depression, and posttraumatic stress disorder (PTSD). These emotion-related disorders have their roots in childhood and adolescence, underscoring a critical need to understand their biological bases in early life. In this dissertation, we evaluate how childhood trauma impacts emotion processing neurocircuitry in a sample of high-risk urban youth, ages 7-15. In four inter-related studies, we test neural function and functional connectivity of core emotion processing regions, including the amygdala, insula, and pregenual/subgenual anterior cingulate cortex (pgACC/sgACC). To examine the relevance of …

An Examination Of Quality Of Life Of Parents Of Adult Children Diagnosed With Autism Spectrum Disorder, Christina Noel Marsack

Wayne State University Dissertations

Previous research on parental caregivers has focused primarily on caregivers of individuals with intellectual and developmental disabilities, rather than focusing specifically on parents of adult children diagnosed with autism spectrum disorder (ASD). Most research on ASD has centered on parents of young children with this diagnosis, but not on parents of adult children with ASD. Understanding the experiences of parents caring for adult children with ASD is important given the increase in the prevalence of individuals with ASD and the lack of information regarding parents of adult children with ASD. A nonexperimental, quantitative, correlational design was used to examine effects …

Principal Component Analysis-Based Anatomical Motion Models For Use In Adaptive Radiation Therapy Of Head And Neck Cancer Patients, Mikhail Aleksandrovich Chetvertkov

Wayne State University Dissertations

Purpose: To develop standard and regularized principal component analysis (PCA) models of anatomical changes from daily cone beam CTs (CBCTs) of head and neck (H&N) patients, assess their potential use in adaptive radiation therapy (ART), and to extract quantitative information for treatment response assessment.

Methods: Planning CT (pCT) images of H&N patients were artificially deformed to create “digital phantom” images, which modeled systematic anatomical changes during Radiation Therapy (RT). Artificial deformations closely mirrored patients’ actual deformations, and were interpolated to generate 35 synthetic CBCTs, representing evolving anatomy over 35 fractions. Deformation vector fields (DVFs) were acquired between pCT and synthetic …

The Impact Of Age On Workplace Motivation: A Person-Centered Perspective, Keith Lynn Zabel

Wayne State University Dissertations

The present study used the person-centered approach to examine how profiles based upon six different age conceptualizations differentially impact workplace motivation. In the first known study to examine all conceptualizations of age simultaneously, results suggested the age conceptualizations of subjective age and health significantly impact growth motives for older workers, but not social or security motives. Results suggest social motives are influenced more by chronological age as opposed to other conceptualizations of age. Implications for practitioners in designing and implementing HR activities (e.g., succession planning) and researchers in utilizing all the conceptualizations of age and studying workplace interventions are discussed.

Recovery Experiences Amongst Arab American Clubhouse Members: Examining The Effects Of Acculturation, Perceived Family Support, Stigma And Gender On Mental Health Recovery., Layla Habhab

Wayne State University Dissertations

ABSTRACT

RECOVERY EXPERIENCES AMONGST ARAB AMERICAN CLUBHOUSE MEMBERS: EXAMINING THE EFFECTS OF ACCULTURATION, PERCEIVED FAMILY SUPPORT, STIGMA AND GENDER ON MENTAL HEALTH RECOVERY

by

LAYLA HABHAB

August 2016

Advisor: Dr. Francesca Pernice –Duca

Major: Educational Psychology

Degree: Doctor of Philosophy

Recovery from serious mental illness has been conceptualized throughout much of the recent literature as being a multidimensional continuum that is influenced by multiple factors. This notion of recovery has mostly been defined by the personal narratives of survivors, ex –patients and mental health consumers with serious mental illness, who have identified specific factors that have either enhanced or hindered …

Diabetes Interaction Study: Communicating Understanding And Social Support, Dana K. May

Wayne State University Dissertations

The current study evaluated a brief individualized feedback intervention developed to improve communication style of parents with an adolescent with type 1 diabetes. Seventy-nine parent-adolescent dyads (13-18 years) were randomized to receive a single session of brief feedback to target parental person-centered communication skills (n = 39) or to receive an educational comparison group (n = 40). Families were asked to discuss a diabetes related problem. A clinician concurrently rated the parent’s communication skills to identify communication strengths and weaknesses. Parents in the feedback group received feedback on their use of person-centered communication during the conversation using motivational interviewing techniques. …

Youth-Led School Health Initiatives: Perceptions And Processes, Lila Murphy Gutuskey

Wayne State University Dissertations

Disparities in obesity prevalence, based on a child’s race and income, establish that health interventions should prioritize these target populations. Additionally, children who are from low-income families in urban neighborhoods and of ethnic minorities have unequal access to environmental determinants of healthy eating (HE) and physical activity (PA). Schools might be the best setting for health interventions, given the understanding that a school’s mission should be to educate the whole child and the substantial amount of time that a child spends in school. The purpose of this study was to examine student-led, school-health interventions in four elementary schools. The Fuel …

Factors Associated With Primary Care Providers' Willingness To Deliver Routine And Transition Care To Transgender Individuals, Deirdre Aisling Shires

Wayne State University Dissertations

Transgender individuals report being denied healthcare services, but very little is known about primary care providers’ (PCP) willingness to deliver either routine or transition care to the transgender community. The purpose of this study is to examine PCP willingness to deliver routine care, continue a hormone therapy (HT) regimen initiated by another provider, and initiate HT for transgender patients using a theoretical framework informed by the Theory of Planned Behavior and Intergroup Contact Theory. The study sample was all family medicine, internal medicine, and women’s health providers in a large integrated Midwestern health system. Eligible participants were emailed a unique …

“I Can See My Values In Places”: Relationships, Place, And Growing Old In Detroit Neighborhoods, Wendy Daniel Bartlo

Wayne State University Dissertations

The central focus of this dissertation is to examine the inextricable link between persons, their social worlds, and their environments. I do this through an ethnographic study of senior members of non-biologically based kinship groups with an affiliation to place. Critical to this examination is the city of Detroit itself, as members of these groups ultimately collectively identify as Detroiters through space and time. It is this collective identity, strengthened mostly through their defense of an outsider deemed unsuccessful city that renders Detroit a good place for the older person to maintain connections, participate socially and civically, and to organize …

Management Safety Climate And Violence Prevention Climate: A Mediational Model For Healthcare Employee Outcomes, Lydia Hamblin Hamblin

Wayne State University Dissertations

Workplace violence is defined as aggressive acts against employees ranging from verbal abuse, threats, and bullying, to physical assault (OSHA, 2002; Jackson, Clare, & Mannix, 2002). The two purposes of this study were (1) to differentiate two specific forms of psychological climate related to workplace violence on a work unit: Violence Prevention Climate (VPC) and Management Safety Climate (MSC), and (2) to test a causal model focusing on the relationship between these climates and their effects on relevant outcomes for at-risk employees in the healthcare industry. MSC was expected to partially mediate the effects of VPC on four outcomes: work …

Identification Of Metabolite Biomarkers In Epilepsy Using 1h Mrs, Helen Wu

Wayne State University Dissertations

Epilepsy is a serious neurological disorder that affects 1% percent of the global population. Despite its status as one of the oldest neurological disorders known to man, its mechanisms remain poorly understood. Available medications are not curative but provide symptomatic management and do not work for well for more than 30 percent of patients. Because it is nearly impossible to predict on an individual level who will eventually develop epilepsy, it is also a disorder that can only be diagnosed after the patient has experienced established seizure activity, eliminating any possibility of stopping the disorder in its prodromal phase, before …

Effects Of 7-Day Repeated Treatment With The 5-Ht2a Inverse Agonist/Antagonist Pimavanserin On Methamphetamine Vs. Food Choice In Male Rhesus Monkeys, Matthew L. Banks L. Banks

Pharmacology and Toxicology Publications

Background

Preclinical drug vs. food choice is an emerging group of drug self-administration procedures that have shown predictive validity to clinical drug addiction. Emerging data suggest that serotonin (5-HT)_2A receptors modulate mesolimbic dopamine function, such that 5-HT_2A antagonists blunt the abuse-related neurochemical effects of monoamine transporter substrates, such as amphetamine or methamphetamine. Whether subchronic 5-HT_2A antagonist treatment attenuates methamphetamine reinforcement in any preclinical drug self-administration procedure is unknown. The study aim was therefore to determine 7-day treatment effects with the 5-HT_2A inverse agonist/antagonist pimavanserin on methamphetamine vs. food choice in monkeys.

Methods …

Identification Of The Metabolic Enzyme Involved Morusin Metabolism And Characterization Of Its Metabolites By Ultraperformance Liquid Chromatogaphy Quadrupole Time-Of-Flight Mass Spectrometry (Uplc/Q-Tof-Ms/Ms), Xianbao Shi, Brianna Mackie, Gang Zhang, Shuman Yang, Yonggui Song, Dan Su, Yali Liu, Lina Shan

Pharmacology and Toxicology Publications

Morusin, the important active component of a traditional Chinese medicine, Morus alba L., has been shown to exhibit many vital pharmacological activities. In this study, six recombinant CYP450 supersomes and liver microsomes were used to perform metabolic studies. Chemical inhibition studies and screening assays with recombinant human cytochrome P450s were also used to characterize the CYP450 isoforms involved in morusin metabolism. The morusin metabolites identified varied greatly among different species. Eight metabolites of morusin were detected in the liver microsomes from pigs (PLMs), rats (RLMs), and monkeys (MLMs) by LC-MS/MS and six metabolites were detected in the liver microsomes from …

Initial Development Of A Patient-Reported Instrument Assessing Harm, Efficacy, And Misuse Of Long-Term Opioid Therapy, William C. Becker, David A. Fiellin, Anne C. Black, Carol T. Kostovich, Robert D. Kerns, Liana Fraenkel

Nursing: School of Nursing Faculty Publications and Other Works

Guidelines on long-term opioid therapy recommend frequent reassessment of harm, efficacy, and misuse of these potentially harmful and sometimes ineffective medications. In primary care, there is a need for a brief, patient-reported instrument. This report details the initial steps in the development of such an instrument. An interdisciplinary team of clinician-scientists performed four discrete steps in this study: (1) conceptualization of the purpose and function of the instrument, (2) assembly of an item pool, (3) expert rating on which items were most important to include in the instrument, and (4) modification of expert-selected items based on a reading level check …

Effect Of Westernization On Oral Health Among College Students Of Udaipur City, India, Piyush Pujara, Neeraj Sharma, Rujul Jayeshkumar Parikh, Maitri Shah, Shachi Parikh, Vivek Vadera, Manpreet Kaur, Isha Makkar, Mayur Parmar, Pratik Rupakar, Shrikant Patel

HPD Articles

BACKGROUND: There is overwhelming evidence that periodontal disease and dental caries affect the majority of populations and that western culture and lifestyle may have a profound influence on oral health, especially in adults. The present study was performed to determine the effect of westernization on the oral health of college students of Udaipur City, Rajasthan. METHODS: A descriptive cross-sectional study was conducted among students attending various professional and non-professional bachelor's degree colleges of Udaipur City, Rajasthan, India, from March 2013 to May 2013. Eight hundred students were selected based on a two-stage random sampling procedure. Westernization was assessed by a …

Blastocystis Sp. Infection Mimicking Clostridium Difficile Colitis, Gaby S. Gil, Shobhana A. Chaudhari, Ahmed Shady, Ana Caballes, Joe Hong

NYMC Faculty Publications

We report an unusual case of severe diarrhea related to Blastocystis sp. infection in a patient with end stage renal disease on hemodialysis. The patient was admitted due to profuse diarrhea associated with fever and leukocytosis. Pertinent stool work-up such as leukocytes in stool, stool culture, clostridium difficile toxin B PCR, and serology for hepatitis A, hepatitis B, and hepatitis C and cytomegalovirus screening were all negative. Ova and parasite stool examination revealed Blastocystis sp. The patient was given intravenous metronidazole with clinical improvement by day three and total resolution of symptoms by day ten.

Effect Of Hypoxic Conditions On Skeletal Myoblasts, Abdo Boumitri, Shuai Zhao

Undergraduate Research Posters 2016

Ischemic injury in skeletal muscle caused by hypoxic (low oxygen) conditions occurs in response to vascular and musculoskeletal traumas, diseases and following reconstructive surgeries. Thus, a thorough understanding of the effect of hypoxia on skeletal myoblasts is warranted to identify potential therapeutic targets. We have determined that treatment with cobalt chloride (to mimic hypoxic conditions) leads to decreased numbers of viable (attached) skeletal myoblast over time and an increase in the percentage of detached myoblasts. To determine the contribution of apoptosis (cell death) to this increase in detached myoblasts, we assessed PARP cleavage, a well- accepted marker for apoptosis. Consistent …