Medicine and Health Sciences Commons^™

Phosphorus Concentrations In The Cuyahoga River Watershed Linked To Anthropogenic Inputs, Christopher Kasden

Undergraduate Research Posters 2016

Twenty-four water samples were taken from twelve sites throughout the Cuyahoga watershed from upstream to downstream within two separate occasions. Twelve samples were taken on May 25th, 2016 with no prior precipitation and the conditions were calm, and twelve samples were taken on July14, 2016 when high precipitation had occurred and water conditions were much more diverse. Using the Automated Discrete Analyzer, the concentrations of phosphorus could be analyzed and differentiated between Total Phosphorus and Soluble Reactive Phosphorus. In comparison to the Environmental Protection Agency whose target concentrations for rivers is .05ppm, in both cases of the experiment the hypothesis …

Defining An Enriched Environment For Pre-Ambulation Training Using A Multi-Directional, Over-Ground Harness System For Young Children With Down Syndrome, Lauren Schuck, Lisa Haecker

Undergraduate Research Posters 2016

This theoretical literature review aims to define the components of an enriched environment (EE) while using a multi-directional, over-ground harness system (MOH), for pre-ambulatory children with Down syndrome (DS). While using an EE has not been clearly defined within humans, children with DS may benefit from this combination of interventions to optimize developmental outcomes. Of the 15 articles critiqued, 6 were found to be most relevant to help define an EE with specific activities when using a MOH for pre-ambulation training. As a part of defining an EE within a MOH, activities will be suggested that stimulate the four components …

The Effects Of Superior Laryngeal Nerve Lesion On Swallowing Kinematics And Airway Protection, Saja Abid, Rebecca Z. German

Undergraduate Research Posters 2016

The superior laryngeal nerve (SLN) carries sensory information from the mucosal tissues of the pharynx superior to the vocal folds, and carries motor signals to the cricothyroid muscles. It also provides partial innervation to the thyroarytenoid and posterior cricoarytenoid muscles. Finally, the SLN initiates the swallow. When a food or liquid bolus is swallowed, the epiglottis and the false and true vocal folds work together to seal off the airway and allow the bolus to pass through the esophagus. If the SLN is damaged, it usually leads to dysphasia in which food or liquid enters the airway. We hypothesized that …

Correlating Wet-Sample Electron Microscopy With Light Scattering Spectroscopy On The Example Of Polymeric Microgels, Christian Gunder

Undergraduate Research Posters 2016

Amphiphilic cellulose-based microgels with a reversible volume-phase transition at around 40.5°C—the low critical solution temperature (LCST)—have been synthesized, characterized, and optimized. After carefully planned synthesis and filtering the samples with a 0.22μm filter microgels were characterized with dynamic light scattering (DLS), yielding reproducible results for the radii of particles around 100-120 nm below the LCST and 60-70 nm above it. Through the use of scanning electron microscopy (SEM), air dried samples and wet samples were also analyzed. Air dried samples were dried for 24 hours until all water was evaporated, ensuring the collapse of microgels as if they were expelling …

Glycerolipid Analysis Of Adaptation To Saline Changes In The Culture Conditions Of Algae, Scenedesmus Dimorphus, By Gc-Ms, Tyler Fitzgerald, Satya Girish Chandra Avula, Chandana Mannem

Undergraduate Research Posters 2016

Since fossil fuels are decreasing over time an alternative energy source will be soon required. The algae, Scenedesmus dimorphus, grows in freshwater and is known for its fast growth of glycerolipid content which is used for biodiesel production. After the algae is grown in optimal conditions, the released fatty acids and glycerolipids are transformed into fatty acid methyl esters (FAMEs) which are used as biodiesel. The FAMEs were quantitatively determined by gas chromatography mass spectrometry (GC-MS) to determine the total glycerolipid content in the different algae samples. The samples that were analyzed include freshwater controls and saline adapted samples. Analysis …

Children's Mercy Hospital Annual Report 2015, Children's Mercy Hospital

Children's Mercy Annual Reports

Annual report for The Children's Mercy Hospital in Kansas City MO, a pediatric medical center.

The State Of Children's Health: 2016 Community Health Needs Assessment For The Kansas City Region, Margo Quiriconi

Community Benefits

The State of Children’s Health: 2016 Community Health Needs Assessment for the Kansas City Region (2016 CHNA) is the second assessment since the Patient Protection and Affordable Care Act of 2010 (ACA) required hospitals to conduct a triennial community health needs assessments. In addition to fulfilling the ACA requirements and subsequent IRS Section H/Form 990 mandate, the 2016 CHNA process is undertaken:
• to examine the current health status of children and identify unmet health needs in the Children’s Mercy leading service area
• to identify the current health priorities—as well as new and emerging health concerns—among children and families …

A Urinary Metabolic Signature For Multiple Sclerosis And Neuromyelitis Optica, Teklab Gebregiworgis, Helle H. Nielsen, Chandirasegara Massilamany, Arunakumar Gangaplara, Jay Reddy, Zsolt Illes, Robert Powers

Jay Reddy Publications

Urine is a metabolite-rich biofluid that reflects the body’s effort to maintain chemical and osmotic homeostasis. Clinical diagnosis routinely relies on urine samples because the collection process is easy and noninvasive. Despite these advantages, urine is an under-investigated source of biomarkers for multiple sclerosis (MS). Nuclear magnetic resonance spectroscopy (NMR) has become a common approach for analyzing urinary metabolites for disease diagnosis and biomarker discovery. For illustration of the potential of urinary metabolites for diagnosing and treating MS patients, and for differentiating between MS and other illnesses, 38 urine samples were collected from healthy controls, MS patients, and neuromyelitis optica-spectrum …

Dogs: A Prescription For Health Issues?, Denise Magallon

Nebraska College Preparatory Academy: Senior Capstone Projects

The human-­‐animal bond has been seen throughout many generations. Pet owners, especially those who own dogs, are known to live a different lifestyle than non-­‐pet owners. However, the individuals who can receive the most benefits from dogs are those with certain psychological and physical health issues. Humans who suffer from diseases find that owning a dog is very helpful and can even improve and/or treat their illness.

Although dogs are not one-­‐hundred percent effective in curing all health conditions, they are still very useful and can improve health even by the slightest result. There is much medical evidence that proves …

Privatization Of Biomedical Research: A Short Term Answer With Long Term Consequences, Frederick Azalekor

Nebraska College Preparatory Academy: Senior Capstone Projects

Biomedical research owned by the government is now available to be owned by private institutions. This results in stagnant innovations because researchers have trouble with all the restrictions that are placed by private institutions. Privatization of biomedical research has short term positive effects but its negative effects are overarching and disastrous. One way to combat this, is for licenses to be deployed slowly with future consequences in mind.

• Privatization has short term benefits but long term disadvantages are disastrous. • To reduce damaging effect, privatization must be deployed slowly and carefully. • Patents or proprietary ownership must be given …

Immigrants And Refugees As Vulnerable Populations: Considerations For School Based Health Centers, Gaïa D. C. Oliver

Master of Public Health Program Student Publications

School based health centers (SBHC) have been shown to benefit domestic populations both in terms of bettering health and bettering academics while being effective over the long term. There is, however, lacking evidence on how they impact immigrant and refugee communities, which are some of the most vulnerable United States communities in terms of health risks. Through discussion of literature, this paper defines and reviews the criteria for vulnerable populations and explains how this term applies to immigrant and refugee populations. School based health centers and their documented health and academic benefits for domestic high risk populations are discussed and …

From Their Home To Ours: Establishing Environmental And Health Literacy Via Urban Gardening For At-Risk Youth, Tiffany B. Hunter

Master of Public Health Program Student Publications

The Global Health concentration of the Master of Public Health highly encourages its students to participate in efforts which promote health and prevent disease either for a cultural group abroad or with a local disparate group (e.g. first-generation immigrants, established minority groups). The current research aimed to develop a similar model of community engagement and health promotion within an urban setting as witnessed in a developing country.

During an internship with Israel’s Ministry of Health, I witnessed a successful community garden and environmental education program designed for children whom reside in an Arab village. Much like the Israeli Arab community …

Application Of Medical Student Research Objectives In An International Medical Elective: Voluntary Medical Male Circumcision In Swaziland, Alison M. Bales, David J. Dennis, Robert C. Siska, Michael A. Schneider, Echo Vanderwal, Harry Vanderwal, Mary C. Mccarthy

Department of Surgery Faculty Publications

No abstract provided.

Evaluating An Online Family Assessment Activity: A Focus On Diversity And Health Promotion, Paul Smith, Melissa Jones

Faculty Publications

This article describes the development, implementation and evaluation of a family assessment activity that was designed for a transition course in an RN-BSN program. The family assessment activity emphasized diversity and health promotion as key curricular concepts highlighted through the use of constructivist teaching strategies in the online classroom. The activity was developed and implemented by utilizing the Family Health Systems (FHS) approach to family assessment and Healthy People 2020 as a framework for family health promotion. The activity was evaluated through faculty observation and student feedback which is discussed in the article.

Service Learning Enhances Conceptual Learning In A Rn To Bsn Program, Henny Breen, Melissa Robinson

Faculty Publications

A qualitative study using transcript analysis was conducted to examine the effectiveness of service learning in enhancing conceptual learning in RN to BSN students. As part of their capstone course in an online program, students engaged in 64 hours of service learning in their local community. The transcripts of asynchronous discussions and journal entries formed the data for analysis. The findings illustrated that the student’s conceptual understanding was enhanced from the service learning experience. Further, the students demonstrated higher-level thinking by linking concepts that could be applied to nursing practice. Service learning reinforced the community-based philosophy of the School of …

2015-2016 Department Of Learning Resources Scholarly Activity Report, Quillen College Of Medicine, East Tennessee State University

Quillen College of Medicine Scholarly Activity Reports

No abstract provided.

Life In Hampton Roads Survey Press Release #2: Police, Crime, Offender Rights, And Attitudes Regarding The Homeless And Mentally Ill In Hampton Roads, Social Science Research Center, Old Dominion University

Life in Hampton Roads Survey Report

[Introductory paragraph]

This report examines regional and sub-regional perceptions of crime and police from the 2016 Life In Hampton Roads survey (LIHR 2016) conducted by the Old Dominion University Social Science Research Center. Data from prior years is also provided when available to show comparisons in responses over time. Responses were weighted by city population, race, age, gender, and phone usage (cell versus land-line) to be representative of the Hampton Roads region.

Systematic Review Of Symptom Clusters In Cardiovascular Disease, Holli A. Devon, Karen Vuckovic, Catherine J. Ryan, Susan Barnason, Julie J. Zerwic, Bunny J. Pozehl, Paula Schulz, Yaewon Seo, Lani Zimmerman

College of Nursing--Lincoln Campus: Faculty Publications

Background: Although individual symptoms and symptom trajectories for various cardiovascular conditions have been reported, there is limited research identifying the symptom clusters that may provide a better understanding of patients’ experiences with heart disease.

Aims: To summarize the state of the science in symptom cluster research for patients with acute coronary syndrome, myocardial infarction, coronary artery bypass surgery, and heart failure through systematic review and to provide direction for the translation of symptom cluster research into the clinical setting.

Methods: Databases were searched for articles from January 2000 through to May 2015 using MESH terms “symptoms, symptom clusters, acute coronary …

Changing Practices To Better Support First-Year Health Science Students, G Hoyne, K Mcnaught

Health Sciences Conference Papers

Entrance to university in Australia, in a post-Bradley era, is diversified and massified, with targets and programs to increase the participation of equity groups that were previously not represented. The changed cohorts have major implications for universities, in meeting the students’ needs, and as a moral and ethical response to enrolment. At the University of Notre Dame Australia (UNDA) Fremantle campus, the 2011 cohort entering Health Sciences, experienced a high rate of failure and withdrawal from university. They entered university at a time when UNDA had begun to implement first year experience (FYE) pedagogical approaches but these had not been …

Pleural Fluid Procalcitonin To Distinguish Infectious From Noninfectious Etiologies Of Pleural Effusions, Rahul Khosla, Shikha Khosla, Kenneth L. Becker, Eric S. Nylen

Medicine Faculty Publications

In this study we investigate the diagnostic value of pleural fluid procalcitonin (PCT) in distinguishing infectious and noninfectious etiologies of pleural effusion. We reviewed the medical records of 75 hospitalized patients who underwent thoracentesis between 2011 and 2012. Data on pleural fluid lactate dehydrogenase (LDH), protein, albumin, cell count and differential, pH, Gram stain and culture, cytology, triglyceride, cholesterol, amylase, and PCT were collected. Data on serum LDH, protein, albumin, prothrombin time, normalized, and blood culture were also collected. Pleural effusions were classified into 2 groups, infectious and noninfectious. There were 18 infectious pleural effusions (IPE) and 57 noninfectious pleural …

Mirnas As Potential Biomarkers In Early Breast Cancer Detection Following Mammography, Sidney W. Fu, Woojin Lee, Caitrin M. Coffey, Alexa Lea, Xiaoling Wu, Xiaohui Tan, Yan-Gao Man, Rachel F. Brem

Medicine Faculty Publications

Breast cancer is the most common cancer among American women, except for skin cancers. About 12 % women in the United States will develop invasive breast cancer during their lifetime. Currently one of the most accepted model/theories is that ductal breast cancer (most common type of breast cancer) follows a linear progression: from normal breast epithelial cells to ductal hyperplasia to atypical ductal hyperplasia (ADH) to ductal carcinoma in situ (DCIS), and finally to invasive ductal carcinoma (IDC). Distinguishing pure ADH diagnosis from DCIS and/or IDC on mammography, and even combined with follow-up core needle biopsy (CNB) is still a …

Cost-Effectiveness Of Asthma Step-Up Therapy As An Increased Dose Of Extrafine-Particle Inhaled Corticosteroid Or Add-On Long-Acting Beta2-Agonist, Nicolas Roche, Gene L. Colice, Elliot Israel, Richard J. Martin, Paul M. Dorinsky, Dirkje S. Postma, +9 Additional Authors

Medicine Faculty Publications

Introduction

Data from different healthcare systems on relative cost-effectiveness of asthma step-up therapy strategies are required to inform decision-makers and clinicians. Our objective was to compare cost-effectiveness from the United Kingdom National Health Service perspective of three step-up strategies for patients with asthma uncontrolled by inhaled corticosteroid (ICS) monotherapy.

Methods

This was a historical matched cohort cost-effectiveness analysis of anonymized medical records for patients with asthma of age 12–80 years. We conducted two-way comparisons of step-up therapy using increased dose (≥50%) of extrafine-particle ICS or add-on long-acting β2-agonist (LABA) via fixed-dose combination (FDC) ICS/LABA inhaler or via separate inhaler. The …

Knowledge, Attitudes, And Practices Of Florida Physicians Regarding Dengue Before And After An Educational Intervention., Susanne Doblecki-Lewis, Aileen Chang, Renee Jiddou-Yaldoo, Kay M Tomashek, Danielle Stanek, Leena Anil, Paola Lichtenberger

Medicine Faculty Publications

BACKGROUND: Failure to recognize and appropriately manage dengue early in the clinical course may result in late initiation of supportive treatment for severe disease. In Florida, travel-related and autochthonous dengue occur and are likely under-recognized. The objective of this study was to evaluate physician knowledge of dengue and its management before and after an educational intervention in Florida.

METHODS: From 2012-13 we conducted 14 grand-rounds style lectures on dengue clinical management attended by 413 physicians, and analyzed data from the pre- and post-tests.

RESULTS: Of those attending, 231 and 220 completed the pre-and post-tests, respectively. Overall, the mean pre-test score …

The Respiratory Protection Effectiveness Clinical Trial (Respect): A Cluster-Randomized Comparison Of Respirator And Medical Mask Effectiveness Against Respiratory Infections In Healthcare Personnel., Lewis J. Radonovich, Mary T. Bessesen, Derek A.T. Cummings, Aaron Eagan, Charlotte A. Gaydos, Cynthia Gibert, Geoffrey J. Gorse, +8 Additional Authors

Medicine Faculty Publications

BACKGROUND: Although N95 filtering facepiece respirators and medical masks are commonly used for protection against respiratory infections in healthcare settings, more clinical evidence is needed to understand the optimal settings and exposure circumstances for healthcare personnel to use these devices. A lack of clinically germane research has led to equivocal, and occasionally conflicting, healthcare respiratory protection recommendations from public health organizations, professional societies, and experts.

METHODS: The Respiratory Protection Effectiveness Clinical Trial (ResPECT) is a prospective comparison of respiratory protective equipment to be conducted at multiple U.S. study sites. Healthcare personnel who work in outpatient settings will be cluster-randomized to …

Knowledge, Attitudes, And Practices Of Florida Physicians Regarding Dengue Before And After An Educational Intervention., Susanne Doblecki-Lewis, Aileen Chang, Renee Jiddou-Yaldoo, Kay M Tomashek, Danielle Stanek, Leena Anil, Paola Lichtenberger

Medicine Faculty Publications

BACKGROUND: Failure to recognize and appropriately manage dengue early in the clinical course may result in late initiation of supportive treatment for severe disease. In Florida, travel-related and autochthonous dengue occur and are likely under-recognized. The objective of this study was to evaluate physician knowledge of dengue and its management before and after an educational intervention in Florida.

METHODS: From 2012-13 we conducted 14 grand-rounds style lectures on dengue clinical management attended by 413 physicians, and analyzed data from the pre- and post-tests.

RESULTS: Of those attending, 231 and 220 completed the pre-and post-tests, respectively. Overall, the mean pre-test score …

A Point Mutation In Dna Polymerase Β (Polb) Gene Is Associated With Increased Progesterone Receptor (Pr) Expression And Intraperitoneal Metastasis In Gastric Cancer, Xiaohui Tan, Xiaoling Wu, Shuyang Ren, Hongyi Wang, Weaam Alshenawy, Wenmei Li, Jiantao Cui, Guangbin Luo, Robert S. Siegel, Sidney W. Fu, Youyong Lu

Medicine Faculty Publications

Increased expression of progesterone receptor (PR) has been reported in gastric cancer (GC). We have previously identified a functional T889C point mutation in DNA polymerase beta (POLB), a DNA repair gene in GC. To provide a detailed analysis of molecular changes associated with the mutation, human cDNA microarrays focusing on 18 signal transduction pathways were used to analyze differential gene expression profiles between GC tissues with T889C mutant in POLB gene and those with wild type. Among the differentially expressed genes, notably, PR was one of the significantly up-regulated genes in T889C mutant POLB tissues, which were subsequently confirmed in …

Disseminated Cryptococcosis With Endobronchial Lesions, Kusha Davar, Arun Jose, Anne Cramer, Alexander Aldrich, Jillian S. Catalanotti

Medicine Faculty Posters and Presentations

No abstract provided.

Metataxonomic And Metagenomic Approaches Vs. Culture-Based Techniques For Clinical Pathology., Sarah K. Hilton, Eduardo Castro-Nallar, Marcos Pérez-Losada, Ian Toma, Timothy A. Mccaffrey, Eric P. Hoffman, Marc O. Siegel, Gary L. Simon, W. Evan Johnson, Keith Crandall

Genomics and Precision Medicine Faculty Publications

Diagnoses that are both timely and accurate are critically important for patients with life-threatening or drug resistant infections. Technological improvements in High-Throughput Sequencing (HTS) have led to its use in pathogen detection and its application in clinical diagnoses of infectious diseases. The present study compares two HTS methods, 16S rRNA marker gene sequencing (metataxonomics) and whole metagenomic shotgun sequencing (metagenomics), in their respective abilities to match the same diagnosis as traditional culture methods (culture inference) for patients with ventilator associated pneumonia (VAP). The metagenomic analysis was able to produce the same diagnosis as culture methods at the species-level for five …

Effect Of The Il-1 Receptor Antagonist Kineret® On Disease Phenotype In Mdx Mice., Margaret E. Benny Klimek, Arpana Sali, Sree Rayavarapu, Jack Van Der Meulen, Kanneboyina Nagaraju

Genomics and Precision Medicine Faculty Publications

Duchenne muscular dystrophy (DMD) is an X-linked muscle disease caused by mutations in the dystrophin gene. The pathology of DMD manifests in patients with progressive muscle weakness, loss of ambulation and ultimately death. One of the characteristics of DMD is muscle inflammation, and dystrophin-deficient skeletal muscles produce higher levels of the pro-inflammatory cytokine interleukin 1β (IL-1β) in response to toll like receptor (TLR) stimulation compared to controls; therefore, blocking the IL-1β pathway could improve the disease phenotype in mdx mice, a mouse model of DMD. Kineret® or IL-1Ra is a recombinant IL-1 receptor antagonist approved by the FDA for treating …

Effects On Muscle Tissue Remodeling And Lipid Metabolism In Muscle Tissue From Adult Patients With Polymyositis Or Dermatomyositis Treated With Immunosuppressive Agents., Ingela Loell, Joan Raouf, Yi-Wen Chen, Rongye Shi, Inger Nennesmo, Helene Alexanderson, Maryam Dastmalchi, Kanneboyina Nagaraju, Marina Korotkova, Ingrid E Lundberg

Genomics and Precision Medicine Faculty Publications

BACKGROUND: Polymyositis (PM) and dermatomyositis (DM) are autoimmune muscle diseases, conventionally treated with high doses of glucocorticoids in combination with immunosuppressive drugs. Treatment is often dissatisfying, with persisting muscle impairment. We aimed to investigate molecular mechanisms that might contribute to the persisting muscle impairment despite immunosuppressive treatment in adult patients with PM or DM using gene expression profiling of repeated muscle biopsies.

METHODS: Paired skeletal muscle biopsies from six newly diagnosed adult patients with DM or PM taken before and after conventional immunosuppressive treatment were examined by gene expression microarray analysis. Selected genes that displayed changes in expression were analyzed …