Medicine and Health Sciences Commons^™

The Effect Of A Powered Ankle Foot Orthosis On Walking In A Stroke Subject: A Case Study, Ali Pourghasem, Ismail Ebrahimi Takamjani, Mohammad Taghi Karimi, Mohammad Kamali, Mohammad Jannesari, Iman Salafian

Department of Mechanical and Materials Engineering: Faculty Publications

[Purpose] Standing and walking are impaired in stroke patients. Therefore, assisted devices are required to restore their walking abilities. The ankle foot orthosis with an external powered source is a new type of orthosis. The aim of this study was to evaluate the performance of a powered ankle foot orthosis compared with unpowered orthoses in a stroke patient.

[Subjects and Methods] A single stroke subject participated in this study. The subject was fitted with three types of ankle foot orthosis (powered, posterior leg spring, and carbon ankle foot orthoses). He was asked to walk with and without the three types …

Motility And Adhesion Through Type Iv Pili In Gram-Positive Bacteria, Kurt H. Piepenbrink, Eric J. Sundberg

Food for Health: Publications

Type IV pili are hair-like bacterial surface appendages that play a role in diverse processes such as cellular adhesion, colonization, twitching motility, biofilm formation, and horizontal gene transfer. These extracellular fibers are composed exclusively or primarily of many copies of one or more pilin proteins, tightly packed in a helix so that the highly hydrophobic amino-terminus of the pilin is buried in the pilus core. Type IV pili have been characterized extensively in Gram-negative bacteria, and recent advances in high-throughput genomic sequencing have revealed that they are also widespread in Gram-positive bacteria. Here, we review the current state of knowledge …

A Novel Codon-Optimized Siv Gag-Pol Immunogen For Gene-Based Vaccination, Catherine M. Crosby, Eric A. Weaver, Reeti Khare, Michael A. Barry

Nebraska Center for Virology: Faculty Publications

Simian immunodeficiency virus (SIV) is a robust pathogen used in non-human primates to model HIV vaccines. SIV encodes a number of potential vaccine targets. By far the largest and most conserved protein target in SIV is its gag-pol protein that bears many epitopes to drive multivalent immune T cell responses. While gag-pol is an attractive antigen, it is only translated after a frame shift between gag and pol with the effect that gag and pol are expressed at an approximate 10/1 ratio. The codon bias of native lentiviral genes are also mismatched with the abundance of tRNAs in mammalian cells …

The Effect Of Frequency Resolution On Intelligibility Sentence And Its Relevance To Cochlear Implant Design, Seth H. Roy

Department of Computer Science and Engineering: Dissertations, Theses, and Student Research

The purpose of this study is to understand how electrical stimulation (as opposed to acoustical stimulation) of the auditory nerve is used in cochlear implants. Speech is a complex signal that changes rapidly in time and frequency domains. Since phonemes (the smallest unit of speech that distinguishes words) depend on nuanced differences in frequency patterns, it would be expected that a signal with drastically reduced frequency information would be of limited value for conveying speech. Such a frequency-poor signal is the object to be investigated in the present work. It is also the basis of the way speech is represented …

Volumetry Of Low-Contrast Liver Lesions With Ct: Investigation Of Estimation Uncertainties In A Phantom Study, Qin Li, Yongguang Liang, Qiao Huang, Min Zong, Benjamin Berman, Marios A. Gavrielides, Lawrence H. Schwartz, Binsheng Zhao, Nicholas Petrick

Food and Drug Administration Papers

Purpose: To evaluate the performance of lesion volumetry in hepatic CT as a function of various imaging acquisition parameters.

Methods: An anthropomorphic abdominal phantom with removable liver inserts was designed for this study. Two liver inserts, each containing 19 synthetic lesions with varying diameter (6–40 mm), shape, contrast (10–65 HU), and both homogenous and mixed-density were designed to have background and lesion CT values corresponding to arterial and portal-venous phase imaging, respectively. The two phantoms were scanned using two commercial CT scanners (GE 750 HD and Siemens Biograph mCT) across a set of imaging protocols (four slice thicknesses, …

Regulation Of Alpha-Herpesvirus Reactivation From Latency By Stress, Insun Kook

School of Veterinary and Biomedical Sciences: Dissertations, Theses, and Student Research

Bovine herpes virus 1 (BHV-1) and Herpes simplex virus 1 (HSV-1) are crucial etiological viral agent of clinical diseases. HSV-1 and BHV-1 establish latent infection in sensory neurons. Periodically, reactivation from latency occurs resulting in virus excretion and transmission. Stress increases corticosteroid levels and the incidence of HSV-1 and BHV-1 reactivation from latency. The synthetic corticosteroid, dexamethasone (DEX) mimics stress and induces BHV-1 and HSV-1 reactivation. However, molecular mechanisms by which corticosteroid mediates viral reactivation are not well understood. My dissertation has focused on elucidating events that induce BHV- 1 or HSV-1 reactivation during the early stages of stress-induced escape …

A Generalized Framework For Computational Design And Mutational Scanning Of T-Cell Receptor Binding Interfaces, Timothy P. Riley, Cory M. Ayres, Lance M. Hellman, Nishant K. Singh, Michael Cosiano, Jennifer M. Cimons, Michael J. Anderson, Kurt H. Piepenbrink, Brian G. Pierce, Zhiping Weng, Brian M. Baker

Food for Health: Publications

T-cell receptors (TCRs) have emerged as a new class of therapeutics, most prominently for cancer where they are the key components of new cellular therapies as well as soluble biologics. Many studies have generated high affinity TCRs in order to enhance sensitivity. Recent outcomes, however, have suggested that fine manipulation of TCR binding, with an emphasis on specificity may be more valuable than large affinity increments. Structure-guided design is ideally suited for this role, and here we studied the generality of structure-guided design as applied to TCRs. We found that a previous approach, which successfully optimized the binding of a …

Methylphenidate And Memory And Attention Adaptation Training For Persistent Cognitive Symptoms After Traumatic Brain Injury: A Randomized, Placebo-Controlled Trial, Brenna C. Mcdonald, Laura A. Flashman, David B. Arciniegas, Robert J. Ferguson, Li Xing, Jaroslaw Harezlak, Gwen C. Sprehn, Flora M. Hammond, Arthur C. Maerlender, Carrie L. Kruck, Karen L. Gillock, Kim Frey, Rachel N. Wall, Andrew J. Saykin, Thomas W. Mcallister

Center for Brain, Biology, and Behavior: Faculty and Staff Publications

The purpose of this multicenter, prospective, randomized, placebo-controlled study was to evaluate and compare the efficacy of two cognitive rehabilitation interventions (Memory and Attention Adaptation Training (MAAT) and Attention Builders Training (ABT)), with and without pharmacologic enhancement (i.e., with methylphenidate (MPH) or placebo), for treating persistent cognitive problems after traumatic brain injury (TBI). Adults with a history of TBI at least four months prior to study enrollment with either objective cognitive deficits or subjective cognitive complaints were randomized to receive MPH or placebo and MAAT or ABT, yielding four treatment combinations: MAAT/MPH (N=17), ABT/MPH (N=19), MAAT/placebo (N=17), and ABT/placebo (N=18). …

Housing In Nonmetropolitan Nebraska: Perceptions Of Supply And Condition: 2016 Nebraska Rural Poll Results, Rebecca J. Vogt, Cheryl A. Burkhart-Kriesel, Randolph L. Cantrell, Bradley Lubben, L. J. Mcelravy

Rural Futures Institute: Publications

Conclusion

Most rural Nebraskans own their home. And, when asked about housing programs or priorities they would support in their community, most rural Nebraskans support programs that help seniors age in their homes, programs that would help upgrade the condition of existing homes and providing affordable rental housing. They are less likely to support organizing volunteer efforts to maintain existing housing stock, but still one-half support this option as well.

Support for one of the programs differs by community size. Persons living in or near larger communities are more likely than persons living in or near smaller communities to support …

Predators Catalyze An Increase In Chloroviruses By Foraging On The Symbiotic Hosts Of Zoochlorellae, John Delong, Zeina Al-Ameeli, Garry A. Duncan, James L. Van Etten, David D. Dunigan Ph. D.

James Van Etten Publications

Virus population growth depends on contacts between viruses and their hosts. It is often unclear how sufficient contacts are made between viruses and their specific hosts to generate spikes in viral abundance. Here, we show that copepods, acting as predators, can bring aquatic viruses and their algal hosts into contact. Specifically, predation of the protist Paramecium bursaria by copepods resulted in a >100-fold increase in the number of chloroviruses in 1 d. Copepod predation can be seen as an ecological “catalyst” by increasing contacts between chloroviruses and their hosts, zoochlorellae (endosymbiotic algae that live within paramecia), thereby facilitating viral population …

Climate Change And The Integrity Of Science, Peter H. Gleick, James L. Van Etten, Members Of The U.S. National Academy Of Sciences

James Van Etten Publications

We are deeply disturbed by the recent escalation of political assaults on scientists in general and on climate scientists in particular. All citizens should understand some basic scientific facts. There is always some uncertainty associated with scientific conclusions; science never absolutely proves anything. When someone says that society should wait until scientists are absolutely certain before taking any action, it is the same as saying society should never take action. For a problem as potentially catastrophic as climate change, taking no action poses a dangerous risk for our planet.

Scientific conclusions derive from an understanding of basic laws supported by …

Community Satisfaction And Marketing In Nonmetropolitan Nebraska: 2016 Nebraska Rural Poll Results, Rebecca J. Vogt, Cheryl A. Burkhart-Kriesel, Randolph L. Cantrell, Bradley Lubben, L. J. Mcelravy

Rural Futures Institute: Publications

Conclusion

By many different measures, rural Nebraskans are positive about their community. Many rural Nebraskans rate their community favorably on its social dimensions: as friendly, trusting and supportive. Most rural Nebraskans say it would be difficult to leave their community. And, most rural Nebraskans disagree that their community is powerless to control its future.

Across all years of this study, rural Nebraskans’ views about the change in their community have generally been positive. The proportion believing their community has changed for the better during the past year has usually been greater than the proportion believing it has changed for the …

Stable Engraftment Of Bifidobacterium Longum Ah1206 In The Human Gut Depends On Individualized Features Of The Resident Microbiome, María X. Maldonado-Gómez, Inés Martínez, Francesca Bottacini, Amy O’Callaghan, Marco Ventura, Douwe Van Sinderen, Benjamin Hillmann, Pajau Vangay, Dan Knights, Robert W. Hutkins, Jens Walter

Department of Food Science and Technology: Faculty Publications

Live bacteria (such as probiotics) have long been used to modulate gut microbiota and human physiology, but their colonization is mostly transient. Conceptual understanding of the ecological principles as they apply to exogenously introduced microbes in gut ecosystems is lacking. We find that, when orally administered to humans, Bifidobacterium longum AH1206 stably persists in the gut of 30% of individuals for at least 6 months without causing gastrointestinal symptoms or impacting the composition of the resident gut microbiota. AH1206 engraftment was associated with low abundance of resident B. longum and underrepresentation of specific carbohydrate utilization genes in the pre-treatment microbiome. …

Regulation Of Ifn-Γ Expression, John Fenimore, Howard A. Young

Public Health Resources

Interferon gamma, referred to here as IFN- γ, is a major component in immunological cell signaling and is a critical regulatory protein for overall immune system function. First discovered in 1965 (Wheelock Science 149: (3681)310–311, 1965), IFN- γ is the only Type II interferon identified. Its expression is both positively and negatively controlled by different factors. In this chapter, we will review the transcriptional and post-transcriptional control of IFN-γ expression. In the transcriptional control part, the regular activators and suppressors are summarized, we will also focus on the epigenetic control, such as chromosome access, DNA methylation, and histone acetylation. The …

Chronic Expression Of Interferon-Gamma Leads To Murine Autoimmune Cholangitis With A Female Predominance, Heekyong R. Bae, Patrick S.C. Leung, Koichi Tsuneyama, Julio C. Valencia, Deborah L. Hodge, Seohyun Kim, Tim Back, Megan Karwan, Anand S. Merchant, Nobuyuki Baba, Dechun Feng, Ogyi Park, Bin Gao, Guo Xiang Yang, M. Eric Gershwin, Howard A. Young

Public Health Resources

In most autoimmune diseases the serologic hallmarks of disease precede clinical pathology by years. Therefore, the use of animal models in defining early disease events becomes critical. We took advantage of a “designer” mouse with dysregulation of interferon gamma (IFNγ) characterized by prolonged and chronic expression of IFNγ through deletion of the IFNγ 3′-untranslated region adenylate uridylate-rich element (ARE). The ARE-Del-/- mice develop primary biliary cholangitis (PBC) with a female predominance that mimics human PBC that is characterized by up-regulation of total bile acids, spontaneous production of anti-mitochondrial antibodies, and portal duct inflammation. Transfer of CD4 T cells from ARE-Del-/- …

Assessing The Archaeoparasitological Potential Of Quids As A Source Material For Immunodiagnostic Analyses, Johnica J. Morrow, Karl Reinhard

Karl Reinhard Publications

In the present study, quids from La Cueva de los Muertos Chiquitos (CMC) were subjected to ELISA tests for 2 protozoan parasites, Toxoplasma gondii (n=45) and Trypanosoma cruzi (n=43). The people who occupied CMC, the Loma San Gabriel, lived throughout much of present-day Durango and Zacatecas in Mexico. The known pathoecology of these people puts them into at-risk categories for the transmission of T. gondii and T. cruzi. Human antibodies created in response to these 2 parasites can be detected in modern saliva using ELISA kits intended for use with human serum. For these reasons, quids were reconstituted and …

Prehistoric Pathoecology As Represented By Parasites Of A Mummy From The Peruaçu Valley, Brazil, Karl Reinhard, Adauto Araújo

Karl Reinhard Publications

Paleopathologists have begun exploring the pathoecology of parasitic diseases in relation to diet and environment. We are summarizing the parasitological findings from a mummy in the site of Lapa do Boquete, a Brazilian cave in the state of Minas Gerais. These findings in context of the archaeology of the site provided insights into the pathoecology of disease transmission in cave and rockshelter environments. We are presenting a description of the site followed by the evidence of hookworm, intestinal fluke, and Trypanosoma infection with resulting Chagas disease in the mummy discovered in the cave. These findings are used to reconstruct the …

Navigating Change: Science Education Leadership Today, James Blake

SciComm 2016 - Lincoln, Nebraska, September 23-24, 2016

What’s new? Three-Dimensional Teaching & Learning

Implications of the Framework and NGSS for Instruction

Shift in Standards

How do we get there?

How Change Looks. How Change Feels.

Numbat Media: A Case Study In The Challenges Of Starting An Outreach Project, Matt Wilkins

SciComm 2016 - Lincoln, Nebraska, September 23-24, 2016

Why do scientists do outreach?

Familiar Outreach Trajectory

Outreach Fatigue

Problem: We’re asking too much of scientists

How do we get our hard-won science resources out to more people?

Numbat Media: Connect scientists (including myself) to the general public

What do we do?

This project needs more hands. Let’s collaborate!

Worldwide Distribution Via Your Local Repository, Paul Royster

SciComm 2016 - Lincoln, Nebraska, September 23-24, 2016

We operate the UNL Digital Commons institutional repository (IR) 87,130 Total Papers, 37,790,242 Total Downloads (since 2005), 6,746,500 Downloads in the past year.

We are the university’s most visited subdomain. Our content ranks above Elsevier’s in Google search results. Sometimes we even beat Wikipedia.

Schematic diagram

Our site looks like this >

Downloads for Dr. Hebets (68 papers). Downloading institutions-- Top 50 schools (of 627) for Eileen Hebets articles. Countries (105) for Eileen Hebets articles. We sent copies of your articles to users in these places.

So free scientific research gets lots of exposure, but ... Free educational resources get even …

The Role Of Design Thinking In Scientific Research & Communication, Colleen Syron

SciComm 2016 - Lincoln, Nebraska, September 23-24, 2016

Design thnking: Research: • Interviews with designers • Observations and case studies • Experimental studies • Simulation • Reflection and theorizing

Designing is not a search for the optimum solution to the given problem, but that it is an exploratory process. The creative designer interprets the design brief not as a specification for a solution, but as a starting point for a journey of exploration,…

“Deduction proves that something must be; Induction shows that something actually is operative; Abduction suggests that something may be.” Charles Pierce

The main point of difference is that of timing. Both artists and scientists operate …

Why We Need To Help Youth Develop A Stem Identity, Saundra Frerichs

SciComm 2016 - Lincoln, Nebraska, September 23-24, 2016

Favorite Toys

Developing Identity

Click 2 Science http://click2sciencepd.org

click2sciencepd.org

click2sciencepd@unl.edu

@Click2Science

Simple Techniques For Behavior Change, Lisa Pennisi

SciComm 2016 - Lincoln, Nebraska, September 23-24, 2016

Myths: •People just need to know the facts •People just need to be aware of the issues & consequences •People just need to see the $$ •Attitudes lead to behavior

Does knowledge lead to behavior?
•Knowledge correlates with behavior True
•Education increases knowledge True
•Increasing knowledge leads to behavior change False

What motivates behavior?

•Awareness campaigns can produce the opposite of goal –they use norms describing undesired behavior •boomerang effects –can cause the opposite effect as some conform with perceived social norms

The problem is WE are the evaluator of potential success based on what works for us. But we …

Networking With Researchers And Farmers To Tackle Herbicide-Resistant Weeds, Melinda K. Yerka

SciComm 2016 - Lincoln, Nebraska, September 23-24, 2016

Outline •Crop breeding technology •Regulation of crop technologies •Issues related to crop-to-weed gene flow •Need for landscape-level studies

GMO •Genetically Modified Organism •Most commercial traits facilitate crop production –Insect resistance (Btcorn) –Herbicide resistance (Roundup) •General scientific consensus that they are safe •Public concerns persist

GM…..Oh? •GMOs are regulated substances by USDA-APHIS –$80 to $150 million per genotype to get to market •USDA-APHIS: Which biotech traits do we regulate? •Commodity groups: Will we be regulated???

The special case of sorghum: Massive international development as a biofuel •Better drought tolerance than corn •Needs herbicide resistance to compete
Evolution of herbicide resistance in …

Training Undergraduates To Sell It: #Scicomm In An Ecology Course, Teresa Bilinski

SciComm 2016 - Lincoln, Nebraska, September 23-24, 2016

Stop. Being. Boring.

Science: Soft Skill? No.

Essential Transferable Skill: “Students would be better served by an education that is integrated with the job market they will encounter post-graduation, and one that provides not only technical skills but also the soft skills that are most in demand by employers such as communication…”

#SciCommin a senior Ecology course: Course-based undergraduate research experience (CURE). Ecosystem services at the wildland-urban interface: involving undergraduates in ecological investigations

Pre- assignment “Summarize the Results of an ecological research project related to the effects of urbanization on ecosystems. The research summaries will be presented orally to the …

Science Communication Strategies In The K-12 Classroom, Andrew Ising

SciComm 2016 - Lincoln, Nebraska, September 23-24, 2016

@ItsIsing

andrewising@gmail

KABT.org #SciComm2016

bit.ly/isingnsc

Why is science literacy important to you? Why is science literacy important to me?

Situation #1: Peer Review -- Scientists talking to other Scientists; Making Science Research More Accessible: Poster Sessions [KABT Miniposters]

Situation #2: Informal Science -- Scientists telling science stories Common sources: Blogs, science magazines, newspapers, etc. Documentaries Social Media Why students like this: Narrative… Drama… Fewer long latin words

Situation #3: Community Outreach -- Scientists talking as experts to an audience “A scientist seen is a scientist trusted” Be/Become someone’s “BROADER IMPACTS”! Citizen Science Projects (Scistarter, YourWildLife, IMP, Great KS Tardigrade Hunt, …

Eight-Legged Encounters: Using Organismal Biology To Bring Science Education To Families & Communities, Eileen A. Hebets

SciComm 2016 - Lincoln, Nebraska, September 23-24, 2016

Path of the Predators: A Journey Through the Living Arachnids. Illustrations by Pawl Tisdale

WHAT IS AN ARTHROPOD?

CREATE A CHELICERATE

ASSEMBLE AN ARACHNID

TISSUE PAPER FLOWER

MICROSCOPE MADNESS

Eight-Legged Encounters Impact

Change in interest in learning about scientific discoveries among adult respondents (n = 63).

Youth’s interest in science activities (n = 42). Respondents were 50% female, 50% male and ranged in age from 4 – 14 with a mean of 7.7.

Inquiry-Based Science Communication Using Plant And Animal Systems, Tiffany Heng-Moss

SciComm 2016 - Lincoln, Nebraska, September 23-24, 2016

Programs:

Our Zoo to YOU: Unique partnership: Nebraska Schools, science educators, scientists, and the Lincoln Children’s Zoo. To provide elementary and middle school educators with a unique opportunity to teach inquiry-based science with live animals. Focus on both teachers and students

Soybeans in the Classroom Research Experience for Teachers--Transformative model of education and professional development focused on: • Systems-approach • Science as inquiry • Integration of agricultural systems as vehicles for science education

Science as Inquiry

Tusker Power: Informal Science Education At The State Museum, Sarah Feit

SciComm 2016 - Lincoln, Nebraska, September 23-24, 2016

Museum Mission:

Research Divisions – University of Nebraska

Ashfall Fossil Beds State Historical Park

Trailside Museum of Natural History

Morrill Hall

Mueller Planetarium in Morrill Hall

Accreditation and Affiliation

Sunday with a Scientist

Investigate: Second Saturday Science Lab

Science Café

Museum NU – Virtual Field Trips

Portal to the Public Network

Building Educator Capacity To Address Animal Agriculture In A Changing Climate, Crystal Powers

SciComm 2016 - Lincoln, Nebraska, September 23-24, 2016

Multi-Regional Approach.

Project Support.

Project Objectives • Equip Educators –ability & motivation • Provide science-based information • Coordinate state, regional and national levels.

Online Course. Outcomes -ability. Outcomes -motivation.

Understand worldviews. Meet people where they are. Start with local history.

Framing: Focus on audience’s values & concerns. Present new information so it can be heard

Science in Action: • Public wants to know how the science applies to their life. • We can point back to the basic science

SciComm Lessons Learned