Medicine and Health Sciences Commons^™

Analysis Of Relapse In Leukemia Patients With Missing Data Using An Extension Of The Em Algorithm, Braydon Schaible

GS4 Student Scholars Symposium

Introduction: Acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) are two types of acute leukemia. When complete remission of leukemia has not been achieved or the disease refracts to its stage in initial chemotherapy, relapse occurs. Leukemia has poor prognosis for patients with relapse. This sample included AML and ALL patients. The purpose of this study was to use and extension of the Expectation-Maximization (EM) algorithm in order to find significant factors that affect the occurrence of relapse in leukemia patients with missing data.

Methods: The EM logistic model consists of three steps. First, the initial logistic regression intercept …

Association Between Fruit And Vegetable Consumption And Sleep Quantity In Pregnant Women, Kassandra Snook

GS4 Student Scholars Symposium

The National Sleep Foundation recommends an average sleep time duration of 7-9 hours per day for adults aged 18-64 years old. Unfortunately, women are prone to encounter sleep disruptions during pregnancy that can prevent them from the recommended amount of sleep. Poor sleep during pregnancy is associated with an increased risk for birth complications, including low birth weight and stillbirth. Studies have found that sleeping less and poor sleep quality is associated with lower consumption of fruits and vegetables and good sleep quality/adequate sleep is associated with increased fruit and vegetable consumption. The objective of this study was to determine …

Airborne Bacterial Exposure At Workers' Breathing Height In An Organic Farm Of Rural Georgia, Tedd Gandy, Nabanita Mukherjee, Bushra Shah, Subhrajit K. Saha, Pratik Banerjee, Atin Adhikari

GS4 Student Scholars Symposium

Organic farming has potentials to contribute substantially to future sustainable agricultural production by improving soil quality, pest control, and reduction of adverse environmental impacts in rural agricultural communities. On the other hand, application of natural farmyard manure may increase the microbial biomass in this environment and consequently microbial exposure levels among workers could be increased. To explore this possibility of excess exposure, particularly to airborne bacteria, we conducted air sampling at the vicinity of poultry and dairy sections of a large organic farm in a rural Georgia location. For air sampling, a Biostage viable cascade impactor was utilized, which comprises …

Microbial Activity And Airborne Culturable Microbial Concentrations In South Georgia Homes, Alli Mcinerney, Jacquelyn Lewis, Errol Spence, Bushra Shah, Atin Adhikari

GS4 Student Scholars Symposium

Indoor microorganisms and microbial allergens can lead to harmful respiratory effects in the human body such as allergies, asthma, chronic bronchitis, infections, and even contamination of food stuffs. This study was conducted in order to test the indoor microbial pollutants in local Statesboro homes, and relate the findings to respiratory disease symptoms of occupants. Thus far, samples have been collected and data analyzed for 15 homes. This specific part of the study focuses on the amount of adenosine triphosphate (ATP) in homes. ATP is a source of energy produced through glucose metabolism and the citric acid cycle. ATP levels can …

Using The Theory Of Reasoned Action To Examine The Knowledge, Attitudes, And Beliefs Among Georgia Physicians Towards The Therapeutic Use Of Medical Cannabis, Shannon Antoine-Hardy

GS4 Student Scholars Symposium

An understanding of the current status of Georgia physiciansÕ knowledge level and attitudes towards medical Cannabis (MC) still remains unknown. Obtaining this information is essential in determining acceptance of MC within local medical communities, as well as influencing the outcomes of political efforts at both the state and federal level. Because science of medical cannabis is generally not required in todayÕs medical training, it is imperative that physicians and other health care professionals close the education gap on MC in clinical care. Therefore, the purpose of the study is to examine physicians' attitudes, knowledge, and beliefs towards the therapeutic use …

Effect Of Natural Products Against Growth Of Three Allergenic And Toxigenic Molds, Brittany Loadholt, Teyaijah Givens, Nosa Lloyd Nwaonumah, Bushra Shah, Atin Adhikari

GS4 Student Scholars Symposium

Dampness and fungal exposures in buildings are widespread, with estimates ranging from 18% to 50% of buildings being affected. Of the 21.8 million people reported to have asthma in the USA, approximately 4.6 million cases are attributable to dampness and mold exposure in the home. Consequent national annual cost of asthma is about $3.5 billion. Several fungal genera from damp environments were reported to be associated with allergy and/or asthma and some species can release mycotoxins in the environment. Although there are several mold inhibitor or disinfectant solutions and sprays available in the market for cleaning and inhibiting mold growth, …

Secondary Data Analysis Based On Children Health Survey: On Factors Associated To Overall Dental Health Of Children In Usa, Kavita Gohil

GS4 Student Scholars Symposium

The mouth is the portal of entry into the body, thus it is essential to attain and maintain oral health care. This process begins from the early period of life. Humans have two sets of teeth, and they start developing even before birth and development lasts till the age of around 25 years. Thus it is essential to take care of teeth during early stages of life, as they can affect overall well-being of the human. This paper describes how children's oral health is affected by external and internal factors and also risk factors which are associated with their oral …

The Impact Of A Nutrition Education Intervention On Self-Reported Feelings Of Food Insecurity, Caitlin Koch

GS4 Student Scholars Symposium

Abstract Unavailable

Ebola And Social Media, Kathryn C. Finch

GS4 Student Scholars Symposium

We were interested in knowing the impact of social media during the 2014-2015 West Africa Ebola epidemic. The aim of this systematic review is to provide clinicians, public health practitioners and policy-makers with a comprehensive overview of the up-to-date literature on Ebola and social media. We critically appraised the quality and utility of these studies, and identified the gaps in our current understanding that invite further research efforts. In particular, we focused on the research questions and the methods of the studies: a) What were the research questions of a given study? b) What study design and research methods were …

Tune Up Your Teaching Toolbox, Anne H. Zachry, J. Flick, S. B. Lancaster

Faculty Presentations

Occupational therapy (OT) educators strive to prepare entry-level practitioners who have the expertise to meet the diverse health care needs of society. A variety of instructional methods are used in the University of Tennessee Health Science Center (UTHSC) MOT program, including traditional lecture-based instruction (LBI), problem-based learning (PBL), team-based learning (TBL), and game-based learning (GBL). Research suggests that active learning strategies develop the critical thinking and problem-solving skills that are necessary for effective clinical reasoning and decision-making abilities. PBL, TBL, GBL are being successfully implemented in the UTHSC MOT Program to enhance the learning process and improve student engagement.

Ohio Academy Of Medical History Annual Meeting Program, April 16, 2016, Ohio Academy Of Medical History

Annual Conference Programs

This program is from the annual meeting of the Ohio Academy of Medical History held on April 16, 2016 at the Health Sciences Library, Medical Heritage Center, at The Ohio State University, in Columbus, Ohio. The program details the events and presentations of the meeting.

Microarray-Based Comparative Genomic And Transcriptome Analysis Of Borrelia Burgdorferi, Radha Iyer, Ira Schwartz

NYMC Faculty Publications

Borrelia burgdorferi, the spirochetal agent of Lyme disease, is maintained in nature in a cycle involving a tick vector and a mammalian host. Adaptation to the diverse conditions of temperature, pH, oxygen tension and nutrient availability in these two environments requires the precise orchestration of gene expression. Over 25 microarray analyses relating to B. burgdorferi genomics and transcriptomics have been published. The majority of these studies has explored the global transcriptome under a variety of conditions and has contributed substantially to the current understanding of B. burgdorferi transcriptional regulation. In this review, we present a summary of these studies with …

Moving Towards Effective Therapeutic Strategies For Neuronal Ceroid Lipofuscinosis., Ryan D. Geraets, Seung Yon Koh, Michelle L. Hastings, Tammy Kielian, David A. Pearce, Jill M. Weimer

Journal Articles: Pathology and Microbiology

The Neuronal Ceroid Lipofuscinoses (NCLs) are a family of autosomal recessive neurodegenerative disorders that annually affect 1:100,000 live births worldwide. This family of diseases results from mutations in one of 14 different genes that share common clinical and pathological etiologies. Clinically, the diseases are subcategorized into infantile, late-infantile, juvenile and adult forms based on their age of onset. Though the disease phenotypes may vary in their age and order of presentation, all typically include progressive visual deterioration and blindness, cognitive impairment, motor deficits and seizures. Pathological hallmarks of NCLs include the accumulation of storage material or ceroid in the lysosome, …

Dr. Carl O. Boucher: Prosthodontist And Dental Editor, Robert B. Stevenson

Annual Conference Presentations, Papers, and Posters

A presentation given at the April 16th, 2016 meeting of the Ohio Academy of Medical History on the life, education, and work of prosthodontist and dental editor, Dr. Carl O. Boucher.

Molecular Treatment Effects Of Alemtuzumab In Skeletal Muscles Of Patients With Ibm., Karsten Schmidt, Konstanze Kleinschnitz, Goran Rakocevic, Marinos Dalakas, Jens Schmidt

Department of Neurology Faculty Papers

BACKGROUND: Mechanisms of inflammation and protein accumulation are crucial in inclusion body myositis (IBM). Recent evidence demonstrated that intravenous immunoglobulin failed to suppress cell-stress mediators in IBM. Here we studied the molecular changes in skeletal muscle biopsies from patients with IBM before and after treatment with alemtuzumab.

METHODS: Relevant inflammatory and degeneration-associated markers were assessed by quantitative-PCR and immunohistochemistry in repeated muscle biopsy specimens from patients with IBM, which had been treated in a previously published uncontrolled proof-of-concept trial with alemtuzumab.

RESULTS: There were no significant changes of the mRNA expression levels of the pro-inflammatory chemokines CXCL-9, CCL-4, and the …

A Vulnerable Population: Ethical Enrollment Of Acute Myocardial Infarction Patients, Shannon Huffaker Rn, Msn, Ccrc

Patient Care Services / Nursing

No abstract provided.

Renewable Resources: The New “Fossil Fuel”, Christopher Huynh, Crystal Vinuya, Gabriel Samaniego, Desiree Caceres, Yessica Moran

Scholarly and Creative Works Conference (2015 - 2021)

Creating ethanol from renewable resources that can be found around our school campus.

College Students’ Stress Coping Strategies, Jatinder Janda

Scholarly and Creative Works Conference (2015 - 2021)

Physical activity is a great coping mechanism for a student stress during college, along with other positive health benefits. However, it may not be the only method to manage stress as a college student, according to my research. Stress goes hand in hand with college so the objective of my literature research was to find a correlation between physical activity and stress. The research demonstrated that along with exercise, family and friend support were also good methods to cope with stress. One reason students are stressed in college is due to concern with their academic performance, however there have not …

Instruments Of Knowledge: Music And The Brain, Anne R. Stoklosa

The Review: A Journal of Undergraduate Student Research

There is little doubt that music plays an important role in cultures all over the world and is an interconnected piece of every society. More specifically, actively engaging in the music by playing a musical instrument, particularly at a young age, has been a hot topic in neuroscience in recent decades. Playing a musical instrument has been shown to increase cognitive ability through enhanced neuronal communication between the left and right hemispheres of the brain, resulting in positive effects on learning, memory, fine motor skills, verbal and non-verbal reasoning, resulting in an overall more capable brain to apply in a …

Bridge/Adapt: Transfer From Computer Remediation To Functional Skill, Janice S. Li, Diana Lopez, Eugene Cheung, Angela Talamantez

Scholarly and Creative Works Conference (2015 - 2021)

This study explored the effectiveness of the Bridge/Adapt program for generalizing increased cognition to functional skills. Three participants, identified as having significant cognitive impairments as measured by the Cognistat assessment, participated in the Bridge/Adapt program, an eight-week program that includes both remedial and compensatory components. The remedial component used was a computer-based cognitive rehabilitation program called Parrot Software. Past studies have proven computer-based cognitive rehabilitation to be effective in increasing overall cognition. The Bridge/Adapt module is the compensatory component that utilized a variety of strategies and everyday tasks to facilitate the generalization of improved cognition to functional performance. A homework …

Adequacy Of End-Of-Life Care Knowledge & Skills In Nursing Education: Investigation Into Family And Nurse’S Experiences In The Critical Care Setting, Educational Needs Of Nurses And Barriers To Adequate Education, Krystal S. Whitaker

Scholarly and Creative Works Conference (2015 - 2021)

In America there’s a paradoxical relationship with dying and death; it’s the one thing that is guaranteed, but often also denied. The stigma surrounding death partly contributes to the lack of training that healthcare professionals receive during their education; the other part is the primary focus in healthcare on curing. Most people will die in the hospital, particularly Intensive Care Units (ICUs) (Holms, Milligan & Kydd, 2014). Being as death and dying have a role in healthcare it would seem to be integral that healthcare professionals would have some education in End-of-Life-Care (EOLC), however it is just the opposite. Across …

Hospice And Oncology Nurses’ Perspectives On Legalizing Physician-Assisted Suicide In California: A Pilot Study, Anna P. Rana

Scholarly and Creative Works Conference (2015 - 2021)

People are living with congenital anomalies, chronic diseases, and disabilities. It is universally agreed upon that every human being has a right to life, however, there is no unanimous decision regarding the right to death. Of the hospice nurses and social workers in Oregon, two-thirds of them reported having a patient ask them about the PAS option (Miller, Harvath, Ganzini, Goy, Delorit, & Jackson, 2004) California, Oregon, Vermont, and Washington have all legalized physician-assisted suicide through legislation. California’s law, the right to death passed on September 11th, 2015. The purpose of this research study is to examine hospice and oncology …

Purification Of Lactate Dehydrogenase, Irene J. Wilson

Scholarly and Creative Works Conference (2015 - 2021)

Lactate dehydrogenase (LDH), sometimes referred to as lactic acid dehydrogenase, is an enzyme that is found in the cytoplasm of almost all living cells. It converts lactate and NAD+ (nicotinamide adenine dinucleotide) to pyruvate and NADH (nicotinamide adenine dinucleotide hydrogen), and it can also catalyze the reverse reaction. Heart muscle is highly oxygenated at all times; therefore, LDH catalyzes the reaction in the direction to form NADH and pyruvate, which is used in the Citric Acid Cycle to make energy for the cell via aerobic cellular respiration. When little or no oxygen (O2) is available to the cell, such as …

Power And Sample Size Calculations For Interval-Censored Survival Analysis, Hae-Young Kim, John M. Williamson, Hung-Mo Lin

NYMC Faculty Publications

We propose a method for calculating power and sample size for studies involving interval-censored failure time data that only involves standard software required for fitting the appropriate parametric survival model. We use the framework of a longitudinal study where patients are assessed periodically for a response and the only resultant information available to the investigators is the failure window: the time between the last negative and first positive test results. The survival model is fit to an expanded data set using easily computed weights. We illustrate with a Weibull survival model and a two-group comparison. The investigator can specify a …

Clinical Factors Associated With Long-Term Complete Remission Versus Poor Response To Chemotherapy In Hiv-Infected Children And Adolescents With Kaposi Sarcoma Receiving Bleomycin And Vincristine: A Retrospective Observational Study, Nader K. El-Mallawany, William Kamiyango, Jeremy Kim Slone, Jimmy Villiera, Carrie L. Kovarik, Carrie M. Cox, Dirk Dittmer, Saeed Ahmed, Gordon E. Schutze, Michael E. Scheurer, Peter N. Kazembe, Parth S. Mehta

NYMC Faculty Publications

Kaposi sarcoma (KS) is the most common HIV-associated malignancy in children and adolescents in Africa. Pediatric KS is distinct from adult disease. We evaluated the clinical characteristics associated with long-term outcomes. We performed a retrospective observational analysis of 70 HIV-infected children and adolescents with KS less than 18 years of age diagnosed between 8/2010 and 6/2013 in Lilongwe, Malawi. Local first-line treatment included bleomycin and vincristine plus nevirapine-based highly active anti-retroviral therapy (HAART). Median age was 8.6 years (range 1.7-17.9); there were 35 females (50%). Most common sites of presentation were: lymph node (74%), skin (59%), subcutaneous nodules (33%), oral …

Abdominal Skin Rash After Tace Due To Non-Target Embolization Of Hepatic Falciform Artery, Prashant Nagpal, Mitesh Bhalala, Nisha Sharma, Dhruv Mehta, Sam Mccabe, Roxana Bodin

NYMC Faculty Publications

Transcatheter arterial chemoembolization (TACE) is a well-recognized procedure for management of hepatocellular carcinoma. We present a 54-year-old man who presented with a periumbilical maculopapular skin rash that developed after an otherwise uneventful TACE procedure. A retrospective review of imaging was consistent with non-target embolization of the hepatic falciform artery (HFA). He was treated with oral non-steroidal antiinflammatory medication for 3 weeks with improvement, but had slight skin induration and an excoriated papule at 6-month follow-up. Non-target embolization of HFA is very rare, but clinicians and interventionalists should be aware of this complication, especially in patients predisposed to enlargement of HFA.

Involvement Of Gap Junctions Between Smooth Muscle Cells In Sustained Hypoxic Pulmonary Vasoconstriction Development: A Potential Role For 15-Hete And 20-Hete, Igor V. Kizub, Anand Lakhkar, Vidhi Dhagia, Sachindra R. Joshi, Houli Jiang, Michael S. Wolin, John R. Falck, Sreenivasulu Reddy Koduru, Ramu Errabelli, Elizabeth R. Jacobs, Michal L. Schwartzman, Sachin A. Gupte

NYMC Faculty Publications

In response to hypoxia, the pulmonary artery normally constricts to maintain optimal ventilation-perfusion matching in the lung, but chronic hypoxia leads to the development of pulmonary hypertension. The mechanisms of sustained hypoxic pulmonary vasoconstriction (HPV) remain unclear. The aim of this study was to determine the role of gap junctions (GJs) between smooth muscle cells (SMCs) in the sustained HPV development and involvement of arachidonic acid (AA) metabolites in GJ-mediated signaling. Vascular tone was measured in bovine intrapulmonary arteries (BIPAs) using isometric force measurement technique. Expression of contractile proteins was determined by Western blot. AA metabolites in the bath fluid …

Little Dresses For Africa, College Of Education And Human Development

Family and Consumer Sciences News

On Saturday, April 2, Fashion Merchandising and Design students applied their clothing design skills to a good cause.

Aging Converts Innate B1a Cells Into Potent Cd8+ T Cell Inducers, Catalina Lee-Chang, Monica Bodogai, Kanako Moritoh, Xin Chen, Robert Wersto, Ranjan Sen, Howard A. Young, Michael Croft, Luigi Ferrucci, Arya Biragyn

United States Public Health Resources

B cell dysregulation in aging is thought to mostly occur in conventional B2 cells without affecting innate B1 cells. Elderly humans and mice also accumulate 4-1BBL+ MHC class-IHi CD86Hi B cells of unknown origin. In this article, we report that these cells, termed 4BL cells, are activated murine and possibly human B1a cells. The activation is mediated by aging human monocytes and murine peritoneal macrophages. They induce expression and activation of 4-1BBL and IFN-gR1 on B1a cells to subsequently upregulate membrane TNF-α and CD86. As a result, activated B1a/4BL cells induce expression of granzyme B in CD8+ T cells by …

Finding Specific, Topic Related Information From A Sea Of Social Media Posts, Scott J. Duberstein, Daniel Asamoah, Derek Doran, Shu Z. Schiller

Celebration of Undergraduate & Graduate Research, Scholarship, and Creative Activities Materials

As social media continues to become an incredible mode of communication in daily life dealing with the exchange of information, these systems provide authors a platform where they can share their thoughts, feelings, and experiences about a number of topics. Harnessing the information expressed publicly through these modes can be incredibly powerful: public perceptions, signals, and data about a variety of specific topics could be extracted and studied from these posts. However, there is a common trade-off in collecting information about a topic from social media: the more specific the topic, generally, the more challenging it is to extract meaningful …