Medicine and Health Sciences Commons^™

Continuing To Confront Copd International Patient Survey: Economic Impact Of Copd In 12 Countries, Jason Foo, Sarah H. Landis, Joe Maskell, Yeon-Mok Oh, Thys Van Der Molen, Meilan K. Han, David M. Mannino, Masakazu Ichinose, Yogesh Punekar

Preventive Medicine and Environmental Health Faculty Publications

Background The Continuing to Confront COPD International Patient Survey estimated the prevalence and burden of COPD across 12 countries. Using data from this survey we evaluated the economic impact of COPD.

Methods This cross-sectional, population-based survey questioned 4,343 subjects aged 40 years and older, fulfilling a case definition of COPD based on self-reported physician diagnosis or symptomatology. Direct cost measures were based on exacerbations of COPD (treated and those requiring emergency department visits and/or hospitalisation), contacts with healthcare professionals, and COPD medications. Indirect costs were calculated from work loss values using the Work Productivity and Activity Impairment scale. Combined direct …

Cognitive Behavioral Therapy For Treatment Of Mild Depression, Justus Ongaga

Nursing Capstones

No abstract provided.

Nitrilase 1 Modulates Lung Tumor Progression In Vitro And In Vivo., Yong Antican Wang, Yunguang Sun, Justin M Le Blanc, Charalambos C. Solomides, Md, Tingting Zhan, Bo Lu, Md

Department of Radiation Oncology Faculty Papers

Uncovering novel growth modulators for non-small cell lung cancer (NSCLC) may lead to new therapies for these patients. Previous studies suggest Nit1 suppresses chemically induced carcinogenesis of the foregut in a mouse model. In this study we aimed to determine the role of Nit1 in a transgenic mouse lung cancer model driven by a G12D Kras mutation. Nit1 knockout mice (Nit1-/-) were crossed with KrasG12D/+ mice to investigate whether a G12D Kras mutation and Nit1 inactivation interact to promote or inhibit the development of NSCLC. We found that lung tumorigenesis was suppressed in the Nit1-null background (Nit1-/-:KrasG12D/+). Micro-CT scans and …

Novel Compound Heterozygous Mutations Expand The Recognized Phenotypes Of Fars2-Linked Disease, Melissa A. Walker, Kyle Mohler, Kyle W. Hopkins, Derek H. Oakley, David A. Sweetser, Michael Ibba, Matthew P. Frosch, Ronald L. Thibert

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Mutations in mitochondrial aminoacyl-tRNA synthetases are an increasingly recognized cause of human diseases, often arising in individuals with compound heterozygous mutations and presenting with system-specific phenotypes, frequently neurologic. FARS2 encodes mitochondrial phenylalanyl transfer ribonucleic acid (RNA) synthetase (mtPheRS), perturbations of which have been reported in 6 cases of an infantile, lethal disease with refractory epilepsy and progressive myoclonus. Here the authors report the case of juvenile onset refractory epilepsy and progressive myoclonus with compound heterozygous FARS2 mutations. The authors describe the clinical course over 6 years of care at their institution and diagnostic studies including electroencephalogram (EEG), brain magnetic resonance …

Improving The State Of Health Literacy Among American Adults: Why Community Outreach Methods Are More Effective Than Literacy-Level Screenings, Lydia Simpson

Honors Theses

Health literacy refers to an individual’s ability to access and process health information to make important decisions about their health. Unfortunately, millions of American adults have inadequate health literacy skills and are not able to navigate their way through the world of health care. This may lead to disastrous consequences and poor health outcomes. To improve health literacy, nationwide health education programs are imperative. Despite this, low health literacy is often ignored, or only considered for individuals suspected of having low health literacy who might then be administered a screening instrument. A better model for the American health care system …

From Mollusks To Medicine: A Venomics Approach For The Discovery And Characterization Of Therapeutics From Terebridae Peptide Toxins, Aida Verdes, Prachi Anand, Juliette Gorson, Stephen Jannetti, Patrick Kelly, Abba Leffler, Danny Simpson, Girish Ramrattan, Mandë Holford

Publications and Research

Animal venoms comprise a diversity of peptide toxins that manipulate molecular targets such as ion channels and receptors, making venom peptides attractive candidates for the development of therapeutics to benefit human health. However, identifying bioactive venom peptides remains a significant challenge. In this review we describe our particular venomics strategy for the discovery, characterization, and optimization of Terebridae venom peptides, teretoxins. Our strategy reflects the scientific path from mollusks to medicine in an integrative sequential approach with the following steps: (1) delimitation of venomous Terebridae lineages through taxonomic and phylogenetic analyses; (2) identification and classification of putative teretoxins through omics …

Insights From Hur Biology Point To Potential Improvement For Second-Line Ovarian Cancer Therapy., Yu-Hung Huang, Weidan Peng, Narumi Furuuchi, James B Duhadaway, Masaya Jimbo, Andrea Pirritano, Charles J Dunton, Gary S Daum, Benjamin E Leiby, Jonathan Brody, Md, Janet A Sawicki

Kimmel Cancer Center Faculty Papers

This retrospective study aimed to investigate the role that an RNA-binding protein, HuR, plays in the response of high-grade serous ovarian tumors to chemotherapeutics. We immunohistochemically stained sections of 31 surgically-debulked chemo-naïve ovarian tumors for HuR and scored the degree of HuR cytoplasmic staining. We found no correlation between HuR intracellular localization in tumor sections and progression free survival (PFS) of these patients, 29 of whom underwent second-line gemcitabine/platin combination therapy for recurrent disease. Ribonucleoprotein immunoprecipitation (RNP-IP) analysis of ovarian cancer cells in culture showed that cytoplasmic HuR increases deoxycytidine kinase (dCK), a metabolic enzyme that activates gemcitabine. The effects …

Framing Professional Programs Within Development Projects: Driving Longer Term Recognition And Integration, Diane Wallace, James Loughman, Kovin Naidoo

Articles

Background: Optometry has, over the past ten years, emerged as a profession strategically positioned to address the burden of uncorrected refractive error in developing countries. Estimates suggest that 285 million people in the world are needlessly visually impaired, mainly due to the lack of trained eye health professionals in the developing world. Development initiatives in eye care have therefore moved away from vertical, service delivery approaches to supporting the establishment of more sustainable, locally owned training programs. This research is based on one the evaluation of one such initiative known as the Mozambique Eyecare Project.

Methods: This study followed a …

Medication Reconciliation: Preventing Errors And Improving Patient Outcomes, Amanda S. Boren

Scholars Week

No abstract provided.

Fall Prevention, Cody Durbin

Scholars Week

During clinical shift at Baptist Health Paducah Hospital on the CCU floor the question asked was, what needs to be researched? After watching the charge nurse help patients all day I asked her what she thought needed to be researched. After thinking for a while she went on to tell me about how they are getting hit pretty hard on infections so there is no need for more research on that. After that she went on to tell me that their fall prevention protocol was lacking pretty badly. They do a fall risk assessment and based on the number decide …

15th Annual Undergraduate Student Symposium, Farquhar Honors College

Undergraduate Student Symposium

The Undergraduate Student Symposium, sponsored by the Farquhar Honors College, presents student projects through presentations, papers, films, and poster displays. The event serves as a “showcase” demonstrating the outstanding scholarship of undergraduate students at NSU. The symposium is open to undergraduate students from all disciplines. Projects cover areas of student scholarship ranging from the experimental and the applied to the computational, theoretical, artistic, and literary. They are taken from class assignments and independent projects. Project presentations can represent any stage in a concept’s evolution, from proposal and literature review to fully completed and realized scholarly work. As in past symposia, …

Ada News - 04/18/2016, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Associations Of Birth Order With Early Adolescent Growth, Pubertal Onset, Blood Pressure And Size: Evidence From Hong Kong’S “Children Of 1997” Birth Cohort, Man Ki Kwok, Gabriel M. Leung, C. Mary Schooling

Publications and Research

Background: Birth order has been proposed as a cardiovascular risk factor, because the lower birth weight and greater infant weight gain typical of firstborns could programme metabolism detrimentally.

Methods: We examined the associations of birth order (firstborn or laterborn) with birth weight-for-gestational age, length/height and body mass index (BMI) z-scores during infancy, childhood, and puberty using generalized estimating equations, with age at pubertal onset using interval- censored regression and with age-, sex- and height-standardized blood pressure, height and BMI z-scores at 13 years using linear regression in a population-representative Chinese birth cohort: “Children of 1997” (n = 8,327).

Results: Compared …

Examining Multi-Session Brief Intervention For Substance Use In Primary Care: Research Methods Of A Randomized Controlled Trial., Jaclyn E Chambers, Adam C Brooks, Rachel Medvin, David S Metzger, Jennifer Lauby, Carolyn M Carpenedo, Kevin E Favor, Kimberly C Kirby

College of Science & Mathematics Departmental Research

BACKGROUND: Brief interventions such as Screening, a single session of Brief Intervention, and Referral to Treatment (SBIRT) have shown mixed effectiveness in primary care. However, there are indications that multi-session brief interventions may demonstrate more consistently positive outcomes, and perhaps a more intensive approach would be of benefit in addressing substance use in primary care. This study compared the effectiveness of SBIRT with a single BI session (BI/RT) to a multi-session brief-treatment intervention (BI/RT+) in primary care. We also developed easy-to-use, evidence-based materials to assist clinicians in delivering these interventions.

METHODS/DESIGN: This study was conducted in three Federally Qualified Healthcare …

A Mir-200c/141-Bmi1 Autoregulatory Loop Regulates Oncogenic Activity Of Bmi1 In Cancer Cells., Mingu Kang, Manjari Dimri, Goberdhan P. Dimri

Biochemistry and Molecular Medicine Faculty Publications

MicroRNAs (miRNAs) are known to function as oncomiRs or tumor suppressors and are important noncoding RNA regulators of oncogenesis. The miR-200c/141 locus on chromosome 12 encodes miR-200c and miR-141, two members of the miR-200 family, which have been shown to function as tumor suppressive miRNAs by targeting multiple oncogenic factors such as polycomb group protein BMI1. Here, we show that BMI1 reciprocally functions as a transcriptional repressor of the miR-200c/141 cluster and that BMI1 inhibitors upregulate expression of miR-200c and miR-141. Our data suggest that BMI1 binds to the miR-200c/141 promoter and regulates it through transcription factor binding motifs E-box …

What's Happening: April 18, 2016, Maine Medical Center

What's Happening

No abstract provided.

1st Place Contest Entry: The Effectiveness Of Yoga Therapy On An Adult, Post-Stroke Population: A Systematic Review, Baylor E. Hogan

Kevin and Tam Ross Undergraduate Research Prize

This is Baylor Hogan's submission for the 2016 Kevin and Tam Ross Undergraduate Research Prize, which won first place. She wrote about the effects of yoga therapy on the physical and mental wellbeing of stroke patients. You can read the final essay that came out of her research here.

Baylor is a senior at Chapman University, majoring in Kinesiology. Her faculty mentor is Dr. Elizabeth DeBaets.

Week Of April 18, 2016, New York Medical College

InTouch

• "Innovation and Inspiration" Fuels Successful NYMedTalks
• SHSP Inducts New Members into Delta Omega and Alpha Eta Honor Societies
• SHSP Hosts Movie Screening to Mark National Public Health Week
• Resident Research Day Recognizes Scholarly Efforts of Residents
• Doc's Café Offers New Mini-Mart

The Components Of Attentiveness In Oncology Care, Klaartje Klaver, Andries Baart

The Qualitative Report

This article presents the first findings of a qualitative empirical study of caregivers' attentiveness in hospital oncology care. It takes a care ethical perspective, in which attentiveness is considered an indispensable element of good care. The data are derived from participant observation at the oncology department of a general hospital in the Netherlands. The analysis shows a descriptive exploratory model of attentiveness, which comprises a coherent set of the clusters perception (A), object finding (B), and space for attentiveness (C). The methodological output of this article is an important one: the presented descriptive model of attentiveness promotes further research into …

Pregnancy And Childbirth Practices Among Immigrant Women From India: “Have A Healthy Baby”, Rama Cousik, M. Gail Hickey

The Qualitative Report

In India, practices relating to pregnancy, childbirth and child development have been rooted in cultural beliefs and traditions that are based on knowledge contained in ancient Indian texts. Many Indians residing across the globe continue to observe these practices. Some may find it challenging to do so when they are residing abroad, away from familiar surroundings and separated from their extended families. A small body of research exists that shows that migrant Indian women do observe traditional maternal practices based on cultural beliefs, but there is a need to learn more about how this knowledge is acquired, disseminated and preserved. …

Bacteriophages: The Answer To Antibiotic Resistance?, Allie Casto, Adam Hurwitz, Kunny Kou, Gregory Mansour, Allison Mayzel, Rachel Policke, Alexander Schmidt, Rowan Shartel, Olivia Smith, Augustus Snyder, Allison Woolf

James Madison Undergraduate Research Journal (JMURJ)

Bacteriophages, viruses that infect bacteria, have numerous applications in the medical, agricultural, and research fields, especially as an alternative to antibiotics in the age of antibiotic resistance. Phages are able to lyse, or break apart, bacterial cells with fewer side effects, more specificity, and less likelihood of resistance than antibiotics. The acceptance of phages in medicine and agriculture around the world today is not universal, and the United States Food and Drug Administration (FDA) has been slow to recognize phage therapy as a legitimate treatment. However, the successful use of phages in the past, as well as promising trial results …

Medical School Watercooler Newsletter - April 17, 2016, Lindsey Lyle

Watercooler Newsletter

This is the April 17, 2016 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents Include:

• USA Surgery Hosts Greater Gulf Coast Trauma and Acute Care Surgery Symposium
• Join Us for National Walk@Lunch Day April 27
• USA Orthopaedic Rehabilitation Center Celebrates Milestone, Plans for Move Later This Year
• Office of Diversity and Inclusion to Host Lecture in Celebration of Minority Health Month

Detection Of Circulating Tumor Cells In Uveal Melanoma By The Photoacoustic Method, Ryan M. Weight, Shingo Sato, Masahiro Ohara, Mizue Terai, Michael Mastrangelo, Marlana Orloff, Benjamin Goldschmidt, John Viator, Takami Sato

Department of Medical Oncology Posters

Abstract

Circulating tumor cells (CTCs) have been shown to be a prognostic marker in breast cancer¹. We hypothesize that circulating melanoma cell (CMC) detection could be utilized in the management of uveal melanoma, including early intervention. Prior methodologies for circulating uveal melanoma cell (CUMC) detection have been fraught with poor sensitivity, limiting their clinical utility². Development of an improved method is necessary to establish the clinical utility of CUMC monitoring. Photoacoustics, also referred to as laser-induced ultrasound, is a novel platform for the detection and capture of CMCs. Photoacoustics uses short duration pulsed light to create …

Acute Groin Pain Following Trauma, Victoria Chen Md

Department of Family Medicine

No abstract provided.

Continuum Of A Declining Trend In Correct Self-Perception Of Body Weight Among American Adults, Amber Morgan

GS4 Student Scholars Symposium

Background: Over the past few decades, the prevalence of obesity in the United States has steadily increased with the proportion of obese Americans projected to be about fifty percent in 2030. With more than half of adults being overweight or obese (OW/OB), an increasing number of adults failed to accurately perceive body weight, which may be a major barrier to weight loss strategies, thus, presenting a substantial challenge to prevention efforts. The objective of this study was to assess the dynamic trend of body weight related self-perception among American adults and provide recommendations for improving obesity prevention strategies.

Methods …

Inhalable Exposure Levels Of Airborne Mold Spores In Rural Georgia Homes, Jacquelyn Lewis, Alli Mcinerney, Errol Spence, Bushra Shah, Atin Adhikari

GS4 Student Scholars Symposium

Exposure to mold is known to cause allergic symptoms. Most molds produce highly allergenic proteins or glycoproteins that can cause hypersensitivity diseases in susceptible hosts. Between 10% and 60% of genetically susceptible persons develop immediate hypersensitivity to mold. The Institute of Medicine report on Damp Indoor Spaces and Health states that there is sufficient evidence to conclude that a causal relationship exists between the presence of mold and upper respiratory tract symptoms, cough, hypersensitivity pneumonitis in susceptible persons, wheeze, and asthma symptoms in sensitized asthmatic persons. To our knowledge, no research has been conducted in rural Georgia to test the …

Predictors Of Having Hpv Vaccination Among Young Adults: A Brfss 2014 Study, Deborah Kanda

GS4 Student Scholars Symposium

Goals and Objectives

The objective of this study is to evaluate the association of social determinants of health on HPV vaccination rates among adults between the ages of 18-34 years.

Theoretical Framework

HPV is the most common sexually transmitted infection. Vaccination has been found to lower the risk of HPV infection. However, HPV vaccination rates still lag behind compared to other recommended vaccines for the same age group. Investigating and addressing factors that affect HPV vaccination rates would support efforts to increase vaccination.

Methodology/Data

Data from the 2014 Behavioral Risk Factor Surveillance System were used for this study. The eight …

Effect Of Natural Products On Overall Microbial Activity In Household Items, Teyaijah Givens, Nosa Lloyd Nwaonumah, Brittany Loadholt, Bushra Shah, Atin Adhikari

GS4 Student Scholars Symposium

Indoor contamination from microorganisms is an important health hazard issue (e.g., respiratory allergy, infections, and food contamination). Particularly, growth of molds and bacteria in damp environmental conditions could be hazardous for the occupants susceptible to microbial allergens. The growing awareness concerning the adverse effects of chlorine bleach and cleaning chemicals calls for field-testing new natural ingredients with functional properties against microorganisms. Essential oils possess a wide spectrum of antimicrobial activity, which may be of great importance for controlling indoor microbial exposure. The objective of this study was to investigate how microbial growth in different surfaces of homes reacted to the …

Effect Of Air Flow Rates In Versatrap Slit Impactor Cassettes On The Collection Of Atmospheric Mold Spores In A Rural Community, Bushra Shah, Tedd Gandy, Oreoluwa Adeyinka, Galela Shebani, Atin Adhikari

GS4 Student Scholars Symposium

Exposure to mold allergens including mold spores and hyphal fragments are associated with allergic sensitization which is a risk factor for asthma in a community. Smaller aerodynamic size of spores (åµm) allows them to penetrate and settle in the lower airways and produce damaging byproducts (allergens, glucans, mycotoxins, and other immunomodulators). Usually mold spores in ambient atmosphere are collected by impactors in air monitoring stations and in most cases these impactors are operated in a single standard air flow rate. However, sampling efficiency of an impactor can change in different air flow rates and since spore aerodynamic sizes vary a …

Effects Of Serum Levels Of Vitamin A And Precursors On Colorectal Cancer Mortlaity, Chimuanya Okoli

GS4 Student Scholars Symposium

Objective: To examine the relationship between serum levels of Vitamin A and precursors on Colorectal cancer mortality. Methods: A retrospective cohort study was conducted with 14,358 adults who participated in NHANES III. Data was collected via in home interviews and visits by participants to a mobile examination centre for blood sample collection. Characteristics such as family income, educational attainment, marital status, race and ethnicity, alcohol consumption, cigarette smoking, self reported health, type of resident, body size, cancer status at base line, vegetable consumption and fruit juice consumption were examined. Hazard ratio estimates for all-cause and cancer-related deaths among individuals with …