Medicine and Health Sciences Commons^™

An Unusual Migration Of A Stent: A Case Report, Fikadu G. Tekleyes Md, Melissa D. Lester Md, Mark A. Studeny Md, Ellen A. Thompson Md, Steven Craig Md

Marshall Journal of Medicine

Stent dislodgment and embolization is a rare complication of coronary stenting.

There are reports of intra-coronary stent entrapment, stripping, and dislodgement

during percutaneous coronary interventions causing potentially life threatening

complications, including intra-coronary or systemic embolization. Reports of

dislodgment and migration of previously placed drug eluting intra-coronary stent

several months after deployment are very limited in the literature. We describe a

drug eluting stent dislodgment and migration in an 88 year-old male 10 months after

its deployment.

Post-Herpetic Paresis Of The Lower Extremity: An Unusual Complication Of Shingles, Leah Diane Stalnaker, Lynne J. Goebel, Md

Marshall Journal of Medicine

Herpes zoster, or shingles, is a disease process caused by re-activation of varicella zoster virus in the dorsal root ganglia. Most commonly, it presents with burning pain and a characteristic vesicular rash. However neurologic complications may occur, most often including neuralgia, and less commonly paresis. We present a case of post-herpetic paresis in an 86- year- old female.

Management Of Co-Existing Lung Cancer And Endobronchal Hamartomas, Mark H. Cooper, Md

Marshall Journal of Medicine

Abstract:

The coexistence of lung cancer with an endobronchial hamartoma is infrequent, and requires accurate oncologic evaluation of the endobronchial lesion prior to potential surgical treatment of the lung cancer. We describe a patient who presented with an undiagnosed endobronchial mass and and a biopsy-proven lung cancer which were successfully managed by a staged approach using initial bronchoscopic resection of the endobronchial lesion and subsequent lobectomy for squamous cell lung cancer.

Modern Evaluation Of Abdominal Trauma, Errington C. Thompson, Md, Chadwick J. Knight, Md

Marshall Journal of Medicine

Abdominal trauma can be mysterious to some physicians. If patients are evaluated for being stable or unstable, then abdominal trauma can be easily managed. Using a combination of physical examination, ultrasound and CT scans, patients can be quickly and efficiently evaluated.

Gradenigo Syndrome: A Rare Complication Of Otitis Media, Paul Brent Ferguson, Md

Marshall Journal of Medicine

Gradenigo syndrome is a very rare complication of otitis media that if left unrecognized and subsequently untreated will result in severe neurologic sequelae. Gradenigo Syndrome clinically represented by the triad of otitis media, ipsilateral, abducens nerve palsy and dysasthesia within the V1 and V2 divisions of the trigeminal nerve branches. We describe a 4 year-old patient who presented with headache, facial pain, diplopia and a recent history of upper respiratory tract symptomatology. Examination revealed an abducens palsy with subsequent magnetic resonance imaging demonstrating inflammation in the left petrous apex and along the tracts of the 6^th, 7^{th …}

Na/K-Atpase Amplification Of Oxidant Stress; A Universal But Unrecognized Clinical Target?, Zijian Xie, Phd, Joseph I. Shapiro, Md

Marshall Journal of Medicine

The Na/K-ATPase has a signaling function which appears to be separate from its ion pumping function. This signaling function refers to the transduction of conformational changes in the Na/K-ATPase alpha1 subunit into activating Src’s tyrosine kinase activity, triggering a cascade which generates reactive oxygen species (ROS), modulates other signaling pathways, and causes many physiological and pathophysiological effects. We have recently observed that ROS themselves as well as cardiotonic steroids can actually initiate the signal by directly inducing conformational changes in alpha1. It therefore appears that the Na/K-ATPase signal cascade can serve as a feed forward amplification for ROS with circulating …

Why Should Busy Clinicians Take Time To Participate In Clinical Research?, Todd H. Davies, Phd

Marshall Journal of Medicine

No abstract provided.

The Prescription Drug Epidemic In Appalachian Elderly, Suzanne Holroyd, Md

Marshall Journal of Medicine

No abstract provided.

Publishing To Progress Science: Shifting The Paradigm From Self To Selfless, Darshana T. Shah Phd

Marshall Journal of Medicine

“Publish or perish" is a phrase coined to describe the pressure in academia to rapidly and continually publish academic work to sustain or further one's career to the next level of academic promotion and to build an academic reputation^1. Prolific publishing increasingly affects funding as well as the reputation of individuals, their institutions, and journals themselves². While the drive behind this increase can be attributed to many factors, the impact can further both the author and the larger medical community. This leads to the juxtaposition of self and selflessness and suggests the question: How is this quantitative …

Timing Of Caffeine Therapy And Neonatal Outcomes In Preterm Infants: A Retrospective Study, Ivan Hand, Nahla Zaghloul, Lily Barash, Rudolph Parris, Ulrika Aden, Hsiu-Ling Li

Publications and Research

Caffeine is widely used to treat apnea of prematurity. Here, we evaluated the efficacy of early caffeine (1-2 DOL) in decreasing the incidence of adverse neonatal outcomes. Methods. A retrospective cohort was used to compare the neonatal morbidity of 150 preterm neonates with gestational age ≤29 weeks. Infants were divided into 3 groups based on the initiation timing of caffeine therapy; (1) early caffeine (1-2 DOL), (2) late caffeine (3–7 DOL), and (3) very late caffeine (≥8 DOL). Results. The neonatal outcomes of early caffeine were comparable with those of the late caffeine group. Moreover, when comparing the neonatal morbidity …

Perceptions Of Adults With Intellectual Disabilities On Experiences At A Weeklong Camp, Erica P. Teilhaber

Honors College Theses

This study was conducted to attempt to understand the perceptions of a weeklong camp experience for adults with Intellectual/Developmental Disabilities. A survey was administered to campers from two of the three locations, asking questions pertaining to their time spent at camp. Specifically researchers asked questions related to the conceptual, social, and practical domains. Additionally, researchers sent a follow up survey to make sure the data they summarized was correct. Results showed positive feedback, and convey the participants perceived improvements in aspects related to the conceptual, social, and practical domains.

Burning The Medication Reconciliation Bridge, Karen Young Rn, Bsn, Marguerite Petsuck Rn, Bsn, Daniel Patzek Rn, Bsn

Patient Care Services / Nursing

No abstract provided.

Breaking The Walls Of Blood Transfusions To Form A Patient Safety Bridge, Karen Young Rn, Bsn, Marguerite Petsuck Rn, Bsn, Daniel Patzek Rn, Bsn

Patient Care Services / Nursing

No abstract provided.

Synthesis And Characterization Of Nanoparticle-Coupled Proteins In Human Serum Albumin, Kyle M. Mahoney

Honors College Theses

Recently, cancer has become an ever-growing issue and has led to many researchers attempt to unravel the mystery of the disease. This research has led to a promising field of treatment: nanotechnology-coupled pharmaceuticals. Nanoparticles act as a whole unit when in conjugation with other molecules and add to the carrier molecule, most often proteins, benefits the nanoparticles themselves possess. One such carrier protein that can be conjugated with nanoparticles is Human Serum Albumin (HSA). Albumin is of interest in cancer research for two reasons: it is native to the human vasculature so it does not elicit immunological reactions, and it …

Tissue-Specific Conditional Pkcε Knockout Mice: A Model To Precisely Reveal Pkcε Functional Role In Initiation, Promotion And Progression Of Cancer, Bilal B. Hafeez, Louise Meske, Ashok Singh, Anupama Singh, Weixiong Zhong, Patricia Powers, Manorama John, Anne E. Griep, Ajit K. Verma

School of Medicine Publications

PKCε is a transforming oncogene and a predictive biomarker of various human cancers. However, a precise in vivo link of PKCε to cancer induction, progression and metastasis remain undefined. To achieve these goals, we generated tissue specific conditional PKCε knockout mice (PKCε-CKO) using cre-lox technology. Homozygous PKCε^LoxP/LoxP mice have normal body weight and phenotype. To determine what effect loss of PKCε would have on the prostate, the PKCε^LoxP/LoxP mice were bred to probasin cre (PB-Cre4⁺) mice which express cre specifically in the prostate epithelium of postnatal mice. Western blot and immunohistochemical analyses showed reduced levels of …

Differential Kinetic Profiles And Metabolism Of Primaquine Enantiomers By Human Hepatocytes, P. S. Fasinu, B. Avula, B. L. Tekwani, N. P. Nanayakkara, Y. H. Wang, H. M. Bandara Herath, J. D. Mcchesney, G. A. Reichard, S. R. Marcisim, M. A. Elsohly, S. I. Khan, I. A. Khan, L. A. Walker

Pharmaceutical Sciences

No abstract provided.

Swosu Research And Scholarly Activity Fair 2016, Lisa Appeddu

SWOSU Research and Scholarly Activity Fair Programs

Welcome to the Twenty-Third SWOSU Research and Scholarly Activity Fair! On display today are 117 presentations involving 187 student researchers, writers, presenters, and artists, and 45 faculty sponsors encompassing scholarly activity from the SWOSU School of Nursing and the SWOSU Departments of Art, Communication, and Theatre; Biological Sciences; Business & Computer Science; Chemistry and Physics; Education; Engineering Technology; Language and Literature; Music; Pharmaceutical Sciences; Psychology; and Social Sciences. In addition, there are poster presentations from the Western Technology Center Biomedical Academy.

Performance Of Sentinel Lymph Node Biopsy In High-Risk Endometrial Cancer., Jessie Ehrisman, Angeles Alvarez Secord, Andrew Berchuck, Paula S Lee, Nicola Di Santo, Micael Lopez-Acevedo, Gloria Broadwater, Fidel A Valea, Laura J Havrilesky

Obstetrics and Gynecology Faculty Publications

OBJECTIVE: To determine the rate and performance of sentinel lymph node (SLN) mapping among women with high-risk endometrial cancers.

METHODS: Patients diagnosed between 2012 and 2015 with uterine cancer of grade 3 endometrioid, clear cell, serous or carcinosarcoma histology and who underwent SLN mapping prior to full pelvic lymph node dissection were included. Subjects underwent methylene blue or ICG injection for laparoscopic (N = 16) or robotic-assisted laparoscopic (N = 20) staging. Outcomes included SLN mapping rates, SLN and non-SLN positive rates, false negative SLN algorithm rate, and the negative predictive value (NPV) of the SLN algorithm. Fisher's exact test …

2016 April 19 - Medical Student Education Committee Minutes, Medical Student Education Committee, East Tennessee State University

Medical Student Education Committee Minutes

No abstract provided.

Novel Agents And Comparative Efficacy In The Prevention And Management Of Post-Herpetic Neuralgia, Laurie A. Chittum

Nursing Capstones

No abstract provided.

Student-Generated E-Learning For Clinical Education, Sarah Nisly, Alex N. Isaacs, Alison M. Walton

Scholarship and Professional Work – COPHS

Background

Within clinical education, e-learning facilitates a standardised learning experience to augment the clinical experience while enabling learner and teacher flexibility. With the shift of students from consumers to creators, student-generated content is expanding within higher education; however, there is sparse literature evaluating the impact of student-developed e-learning within clinical education. The aim of this study was to implement and evaluate a student-developed e-learning clinical module series within ambulatory care clinical pharmacy experiences.

Methods

Three clinical e-learning modules were developed by students for use prior to clinical experiences. E-learning modules were created by fourth-year professional pharmacy students and reviewed by …

A Direct Quantification Method For Measuring Plasma Micrornas Identified Potential Biomarkers For Detecting Metastatic Breast Cancer., Qian Zhao, Shengqiong Deng, Guangxue Wang, Cuicui Liu, Lingyu Meng, Shanshan Qiao, Lei Shen, Yue Zhang, Jinhui Lü, Yuzhen Zhang, Min Wang, Richard Pestell, Chunli Liang, Zuoren Yu, Wenshu Li

Department of Cancer Biology Faculty Papers

Circulating miRNAs are protected from ribonuclease degradation by assembly into microvesicles and exosomes. Releasing miRNAs completely from these particles is the key step to quantify the circulating miRNAs. Currently purified RNA-based quantitative analysis is widely used while it is time and cost consuming with high risk for those circulating miRNAs with low abundance due to partial loss of RNA during the steps of total RNA extraction and small RNA enrichment. Herein, we optimized a simple, effective and time-saving method to directly measure plasma miRNAs without RNA isolation. It is based on complete miRNA release from the protein complexes, followed by …

Quantifying Syringe Exchange Program Operational Space In The District Of Columbia., Sean T. Allen, Monica Ruiz, Jeff Jones

Prevention and Community Health Faculty Publications

Syringe exchange programs (SEPs) are effective structural interventions for HIV prevention among persons who inject drugs. In 2000, a buffer zone policy (the 1000 Foot Rule) was implemented in Washington, DC, that prohibited SEP operations within 1000 feet of schools. We examined changes in the amount of legal SEP operational space over time. We used data pertaining to school operations and their approximate physical property boundaries to quantify the impact of the 1000 Foot Rule on legal SEP operational space from its implementation in 2000-2013. Adherence to the 1000 Foot Rule reduced SEP operational space by more than 50 % …

Brucker And Potter Lectures Posted In The Jdc, Daniel G. Kipnis, Msi

Jefferson Digital Commons News

In case you missed these recent campus events, recordings are now available in the Jefferson Digital Commons for: 

Strangers in a Strange Land: Primary Care and Academic Medical Centers (24th Annual Paul C. Brucker, MD Lecture presented by Thomas L. Schwenk, MD, Dean, University of Nevada School of Medicine, Reno) – This annual series of lectures was established in 1990 to honor the former Dean’s important contributions to Thomas Jefferson University and to American medicine.

A Mitochondrial Etiology of Complex Diseases (2016 William Potter Lecturepresented by Douglas C. Wallace, PhD, University of Pennsylvania) – The Potter Lecture is sponsored …

Ictal Asystole In A Patient With Posterior Reversible Encephalopathy Syndrome (Pres) And Seizures: A Case Report, Joanna Suski, Md, Reginald T. Ho, Md, Maromi Nei, Md

Department of Neurology Posters

BACKGROUND

• Ictal asystole is rare, seen in less than 1% of patients with epilepsy, and typically seen in patients with temporal or frontal lobe seizures, rarely in occipital lobe seizures, and has never been described in a patient with PRES .
• PRES is a clinical-radiologic diagnosis in which there is a breakdown of the blood brain barrier caused by abrupt changes of blood pressure, or cytokines causing endothelial damage and this creates brain edema.
• The typical neurological symptoms of PRES include encephalopathy (50-80%), seizure (60-75%), headache (50%), and visual disturbance (35%).
• Brain imaging in PRES usually reveals vasogenic edema in …

Sonographic Findings Of A Semi-Professional Football Player With 1st Mtp Joint Pain: Gout Or Turf Toe?, David Jeong, Md, Caqsm, Cep, Rmsk, Danielle Snyderman, Md, Lauren Hersh, Md, Jeremy Close, Md

Department of Family & Community Medicine Posters

Purpose

Aim : To review the applications and indications of sonography for forefoot disorders, especially gout and plantar plate injury of 1^st MTP joint.

Introduction

• Forefoot disorders are common but forefoot ultrasound is underutilized.
• Point-of-Care Ultrasound was utilized in initial workup evaluating acute on chronic 1^st MTP joint pain in our case study.

Composite Split Cord Malformation Associated With A Dermal Sinus Tract, Dermoid Cyst, And Epidural Abscess: A Case Report And Review Of Literature, Saad Akhtar, Abdul Azeem, Muhammad Shahzad Shamim, Muhammad Zubair Tahir

Section of Neurosurgery

Background: Split cord malformation (SCM) is typically present at a single level but rarely, may be present at multiple levels in the spinal cord and can be associated with a wide array of lesions such as myelomeningoceles, lipomas, teratomas, and dermal sinus tracts (DSTs).
Case description: We describe a case of a 15-month-old female child who presented with high-grade fever and progressive motor weakness in the lower limbs. Magnetic resonance imaging revealed the presence of SCM along with an epidural abscess, DST, and dermoid cyst. The child underwent surgery for excision of DST along with removal of the dermoid cyst …

Occupational Therapy Discharge Planning And Recommendations In Acute Care: An Action Research Study, Helene Smith-Gabai

Occupational Therapy Program Student Theses, Dissertations and Capstones

In today’s health care environment of quick discharges and shortened hospital stays discharge planning has become increasingly important in acute care occupational therapy practice. Discharge planning is a complex process and an important aspect of patient care as poor discharge planning has been associated with poor patient outcomes and increased risk of adverse events and readmission. This study addressed the following research questions: (a) How do acute care occupational therapists describe their role in the discharge planning process? (b) What guides acute care occupational therapists discharge decisions and recommendations? (c) How do acute care occupational therapists define optimal discharge planning? …

Exploits Of A Helicopter Tv Journalist, Jerry Foster

ERAU Prescott Aviation History Program

Jerry Foster was the first TV helicopter pilot/reporter in the country; the first to go live over the scene of a breaking story. High speed police chases; devastating floods and daring rescues now splashed all over cable TV, started in the early 1970s in Phoenix. Hear this fascinating story from a remarkable aviator who won the Harmon Trophy for his flying exploits. What he pioneered would later be copied by medical and law enforcement agencies throughout the country leading to the saving of countless lives.

Vulcan Nerve Pinch: Atypical Shoulder Pain In An Active Bariatric Patient, Nicholas Kitsopoulos Do, Laura M. Dunne Md

Department of Family Medicine

No abstract provided.