Medicine and Health Sciences Commons^™

Smoker's Paradox In Patients With St-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention, Tanush Gupta, Dhaval Kolte, Sahil Khera, Prakash Harikrishnan, Marjan Mujib, Wilbert S. Aronow, Diwakar Jain, Ali Ahmed, Howard A. Cooper, William H. Frishman, Deepak L. Bhatt, Gregg Fonarow, Julio A. Panza

NYMC Faculty Publications

BACKGROUND: Prior studies have found that smokers undergoing thrombolytic therapy for ST-segment elevation myocardial infarction have lower in-hospital mortality than nonsmokers, a phenomenon called the "smoker's paradox." Evidence, however, has been conflicting regarding whether this paradoxical association persists in the era of primary percutaneous coronary intervention.

METHODS AND RESULTS: We used the 2003-2012 National Inpatient Sample databases to identify all patients aged ≥18 years who underwent primary percutaneous coronary intervention for ST-segment elevation myocardial infarction. Multivariable logistic regression was used to compare in-hospital mortality between smokers (current and former) and nonsmokers. Of the 985 174 patients with ST-segment elevation myocardial …

Exploring The Impact Of Globalization On Linguistic Culture, Autumn Kearney

Honors Theses

Awareness and mastery of a country’s cultural norms provides a person with access to public services, ceremonies, traditions and an unlimited number of other dimensions that would be otherwise unavailable. This study looks specifically at linguistic culture, which is the entirety of views, attitudes, assumptions and other ideas people acquire about language (Schiffman, 2012). Although the linguistic climate in the U.S Midwest is different than that in Senegal, one cannot fully understand either culture without knowledge of the linguistic culture in both country contexts. This study examines the linguistic cultures in both country contexts and uses ethnomethodology to examine the …

The Effects Of Globalization On English Language Learning: Perspectives From Senegal And The United States, Anna Poggensee

Honors Theses

This study is an analytical comparison among perspectives about English as a nonnative language and its function in Senegal, West Africa and the U.S. Midwest. The purpose of this study is to establish a better understanding of the effects of globalization in both countries by focusing on the increasing use of the English language (Crystal, 2003) and how it is used within diverse societies. Globalization can be defined as “the interconnections of global economic, political, cultural and environmental processes that continually transform present conditions” (Steger, 2003, p.7-8).Within the context of globalization, this topic allows for a broader understanding of the …

Using Sbirt As An Intervention For Substance Use In Public Schools, Amanda Higgins

Honors Theses

In Kalamazoo County, youth substance use is on the rise. In recent years (2012-2014), alcohol use has nearly doubled in the adolescent population. With the easy accessibility of alcohol in Kalamazoo, alcohol use among adolescents will continue to rise if early intervention protocols are not implemented. Screening, Brief Intervention, and Referral to Treatment (SBIRT), could be the model of intervention within Kalamazoo public schools, if implemented correctly. According to the Substance Abuse and Mental Health Service Administration (SAMHSA), SBIRT is an evidence-based practice used to identify, reduce, and prevent problematic use, abuse, and dependence on alcohol and illicit drugs. Public …

Treatment Of Dental Complications In Sickle Cell Disease., Priti Mulimani, Samir K. Ballas, Adinegara B L Abas, Laxminarayan Karanth

Cardeza Foundation for Hematologic Research

BACKGROUND: Sickle cell disease is the most common single gene disorder and the commonest haemoglobinopathy found with high prevalence in many populations across the world. Management of dental complications in people with sickle cell disease requires special consideration for three main reasons. Firstly, dental and oral tissues are affected by the blood disorder resulting in several oro-facial abnormalities. Secondly, living with a haemoglobinopathy and coping with its associated serious consequences may result in individuals neglecting their oral health care. Finally, the treatment of these oral complications must be adapted to the systemic condition and special needs of these individuals, in …

Blastomyces: Why Be Dimorphic?, Dennis J. Baumgardner

Journal of Patient-Centered Research and Reviews

In introducing the infectious disease focus for this edition of the Journal of Patient-Centered Research and Reviews, the author describes the unsolved mysteries surrounding the dimorphic fungus Blastomyces and the related pathogenesis of pulmonary blastomycosis.

Epidemiology Crucial To Cracking Elizabethkingia Crisis, Angela Tonozzi

Journal of Patient-Centered Research and Reviews

The author explains the epidemiological methods, tools and personnel required to pinpoint the source of Wisconsin’s 2016 outbreak of Elizabethkingia infections.

Disease-Causing Fungi In Homes And Yards In The Midwestern United States, Dennis J. Baumgardner

Journal of Patient-Centered Research and Reviews

A number of fungal pathogens that may result in a variety of human diseases are found in residential homes and yards. The growth of these microscopic fungi is often favored by particular characteristics of the dwelling and nearby outdoor environment. Evolved virulence factors or increased ability of specific fungi to grow in diverse, and sometimes harsh, microenvironments presented by the domestic environment may promote growth and pathogenesis. Infection may occur by inhalation or direct inoculation and include endemic fungi in addition to opportunistic or emerging species. Systemic or locally aggressive fungal infections are particularly likely and may be life-threatening in …

Antifungal Activity Of Essential Oils On Aspergillus Parasiticus Isolated From Peanuts, Mina M. Yooussef, Quyen Pham, Premila Achar, Marikunte Yanjarappa Sreenivasa

Faculty Articles

Aspergillus parasiticus is one of the most common fungi which contaminates peanuts by destroying peanut shells before they are harvested and the fungus produces aflatoxins. The aim of this study was to evaluate the antifungal activities of seventeen essential oils on the growth of the aflatoxigenic form of A. parasiticus in contaminated peanuts from commercial outlets in Georgia. The agar dilution method was used to test the antifungal activity of essential oils against this form of A. parasiticus at various concentrations: 500; 1,000; 1,500; 2,000; 2,500 ppm. Among the seventeen essential oils tested, the antifungal effect of cinnamon, lemongrass, clove …

Antibacterial Derivatives Of Marine Algae: An Overview Of Pharmacological Mechanisms And Applications, Emer Shannon, Nissreen Abu-Ghannam

Articles

The marine environment is home to a taxonomically diverse ecosystem. Organisms such as algae, molluscs, sponges, corals, and tunicates have evolved to survive the high concentrations of infectious and surface-fouling bacteria that are indigenous to ocean waters. Both macroalgae (seaweeds) and microalgae (diatoms) contain pharmacologically active compounds such as phlorotannins, fatty acids, polysaccharides, peptides, and terpenes which combat bacterial invasion. The resistance of pathogenic bacteria to existing antibiotics has become a global epidemic. Marine algae derivatives have shown promise as candidates in novel, antibacterial drug discovery. The efficacy of these compounds, their mechanism of action, applications as antibiotics, disinfectants, and …

The Relationship Between Canine Nasal Length And Second-Hand Smoke Cotinine Levels, Sierra Wilson, Terry Derting

Scholars Week

Second-hand smoke (SHS) has been associated with respiratory cancers in canines, with the predisposed locations determined by the cephalic ratio (head length / head width). Exposure to SHS is frequently measured by analyzing urine or blood samples for the nicotine by-product cotinine. We investigated the suitability of saliva as an alternative source for cotinine analyses in dogs because obtaining saliva is less invasive and cotinine concentrations from SHS exposure are instantaneously measurable in saliva compared to other collection methods. Specifically, we tested for a quantitative relationship between cephalic ratio and the salivary concentration of cotinine. Our null hypothesis was that …

Advocating For Our Patients Using Clinical Research, Brandon Baker

Clinical Research in Practice: The Journal of Team Hippocrates

This reflection is about experiences trying to relate medical research evidence to actual patient care. This piece talks about shared decision-making about screening mammography.

Examining Cognitive And Emotional Responses To Inter-Age Rejection, Kristina M. Deem

Morehead State Theses and Dissertations

A Thesis Presented to the Faculty of the College of Science and Technology Morehead State University in Partial Fulfillment of the Requirements for the Degree Master of Science by Kristina M. Deem on April 21, 2016.

Coronary-Artery Bypass Surgery In Patients With Ischemic Cardiomyopathy, Eric J. Velazquez, Julio A. Panza, Torsten Doenst, Patrice Desvigne-Nickens, George Sopko, Stiches Investigators

NYMC Faculty Publications

BACKGROUND: The survival benefit of a strategy of coronary-artery bypass grafting (CABG) added to guideline-directed medical therapy, as compared with medical therapy alone, in patients with coronary artery disease, heart failure, and severe left ventricular systolic dysfunction remains unclear.

METHODS: From July 2002 to May 2007, a total of 1212 patients with an ejection fraction of 35% or less and coronary artery disease amenable to CABG were randomly assigned to undergo CABG plus medical therapy (CABG group, 610 patients) or medical therapy alone (medical-therapy group, 602 patients). The primary outcome was death from any cause. Major secondary outcomes included death …

Concussions, Why They Go Unreported, Drake Matuska

Celebrating Scholarship & Creativity Day (2011-2017)

Introduction: In the world today, concussions are a major health risk in sports and many other physically demanding activities. Every day, we see former athletes who have experienced multiple concussions complain of cognitive impairment and memory loss. It is the risk every athlete takes when they participate in a sport they love; however, when an individual plays through a concussion that is when a line is crossed. People playing through a concussion lead to the foundation of this study, which is to find out why individuals play through their concussions, why they fail to report, and the core cognitive reasons. …

2016 - The Twenty-First Annual Symposium Of Student Scholars

Symposium of Student Scholars Program Books

The full program book from the Twenty-first Annual Symposium of Student Scholars, held on April 21, 2016. Includes abstracts from the presentations and posters.

Challenges And Successes: Integrating Patient Education In The Emr, Joanne Stewart Bsn, Rn-Bc, Rnc-Ob

Department of Education

No abstract provided.

Molecular Mechanism Of Protein Kinase Recognition And Sorting By The Hsp90 Kinome-Specific Cochaperone Cdc37, Dimitra Keramisanou, Adam Aboalroub, Ziming Zhang, Wenjun Liu, Devon Marshall, Andrea Diviney, Randy W. Larsen, Ralf Landgraf, Ioannis Gelis

Chemistry Faculty Publications

Despite the essential functions of Hsp90, little is known about the mechanism that controls substrate entry into its chaperone cycle. We show that the role of Cdc37 cochaperone reaches beyond that of an adaptor protein and find that it participates in the selective recruitment of only client kinases. Cdc37 recognizes kinase specificity determinants in both clients and nonclients and acts as a general kinase scanning factor. Kinase sorting within the client-to-nonclient continuum relies on the ability of Cdc37 to challenge the conformational stability of clients by locally unfolding them. This metastable conformational state has high affinity for Cdc37 and forms …

In Synch But Not In Step: Circadian Clock Circuits Regulating Plasticity In Daily Rhythms, Jennifer A. Evans, M. R. Gorman

Biomedical Sciences Faculty Research and Publications

The suprachiasmatic nucleus (SCN) is a network of neural oscillators that program daily rhythms in mammalian behavior and physiology. Over the last decade much has been learned about how SCN clock neurons coordinate together in time and space to form a cohesive population. Despite this insight, much remains unknown about how SCN neurons communicate with one another to produce emergent properties of the network. Here we review the current understanding of communication among SCN clock cells and highlight a collection of formal assays where changes in SCN interactions provide for plasticity in the waveform of circadian rhythms in behavior. Future …

Cardiac Tissue Engineering: Using Induced Pluripotent Stem Cells To Repair Damaged Cardiac Tissue, Megan Lenz

Celebrating Scholarship & Creativity Day (2011-2017)

Heart Disease is the number one cause of death in the United States and affects many individuals on a daily basis. The purpose of this research was to explore possible tissue regeneration therapies that aim to improve and recover function of damaged myocardial tissue commonly seen as a side-effect of chronic heart disease. Cardiac tissue engineering using induced pluripotent stem cell derived cardiomyocytes (iPSC-CMs) is a relatively new method that involves dedifferentiating cells from any tissue of the host into pluripotent stem cells. These cells are then guided to be differentiated into functioning myocardial cells that can be used to …

Emphasizing Learning How To Learn In A Nursing Course, Belinda Deal, Zhaomin He, Katy Zagurski

Faculty Posters

This poster was presented during The Lyceum: A Student Research Showcase, and event hosted by the UT Tyler Center for Teaching Excellence and Innovation and UT Tyler Honors Program.

Hydration Status, Habits, And Knowledge Of Collegiate Cross Country Runners, Laura J. Comee

Celebrating Scholarship & Creativity Day (2011-2017)

Abstract: Dehydration exceeding 2% loss of body mass can cause decreased cognitive and physical performance in endurance athletes. While many runners carry water bottles with them, most do not know their sweat rate or fluid recommendations, increasing the risk for heat-related illnesses such as heat stroke. Purpose: To assess hydration status, habits, and knowledge of collegiate cross country runners. Methods: Institutional Review Board approval was obtained and subjects completed informed consents. Thirty-three female and twenty-five male Division III collegiate runners participated in the study. Hydration status was assessed measuring the specific gravity of three urine samples one each …

Andrews Receives Gold Level Status: Award From American College Of Sports Medicine For Health & Wellness, Alixandria Reiner

Andrews Agenda: Campus News

No abstract provided.

The Evolution Of The U.S. Catholic Hospital: From Sisters In Habits To Men In Suits, Michael Greenstein

Celebrating Scholarship & Creativity Day (2011-2017)

In today’s ever-changing healthcare landscape, Catholic U.S. hospitals have undergone a change in their mission and thus their identity. This paper argues that Catholic hospitals need to rediscover the origins of their ministry. This can be accomplished by refocusing their efforts away from mergers with secular entities that deal strictly with life and death issues to mergers that more fully engage the care for the poor and vulnerable. To provide the context for this paper, Part One will present an overview of Jesus’ ministry, which is the foundation for Catholic health care. Part Two will address the history of the …

Clinical Readiness - Unique Strategies To Empower Clinical Transformation For Ehmr Implementation, Marjorie Lavin Rn, Ms, Cnrn

Patient Care Services / Nursing

No abstract provided.

Improving The Breast Milk Scanning Process, Cheryl Kraemer Msn, Rn-Bc, Rnc-Ob

Patient Care Services / Nursing

No abstract provided.

Spanning The Bridge To Patient Safety During An Ehr System Downtime, Susan Teti Msn, Rn; Clinical Informatics

Patient Care Services / Nursing

No abstract provided.

The Effects Of Aging And Estrogen Treatment During Aging On The Rat Epididymis, Kathryn Davis

Honors Theses

Previous studies from our lab have demonstrated that a normal estrogen environment in the testis contributes to maintaining spermatogenesis in adult rats and that estrogen treatment can attenuate the age-associated decline in sperm production. The purpose of this study was to determine if the estrogen environment of the epididymis is altered with age and what effects estrogen treatment may have on the epididymis during aging. The study compared untreated rats at 15 months of age to 18 month old rats that were treated with either vehicle, or estradiol- valerate, once every third day from 15 to 18 months. Mean concentrations …

Design Of Medical Devices For Diagnostics In The Gastrointestinal System, Charles R. Welch

Department of Mechanical and Materials Engineering: Dissertations, Theses, and Student Research

This thesis presents the design, controls, and testing of two systems: a novel colonoscope locomotion design for diagnostics, and a biosensor capsule that implants a sensor in the small intestine. Each system requires special design considerations for use in the gastrointestinal system.

Colonoscopy procedures are recommended as a screening for colon cancer and related conditions after the age of 50. The need for an improved colonoscope that reduces the colonoscopy time and patient discomfort is apparent. The semi-autonomous device presented here could likely reduce the colonoscopy procedure time by allowing the physician to focus more on the diagnosis and less …

Use Of Surface-Enhanced Laser Desorption/Ionization With Time Of Flight (Seldi-Tof) Of The Urine In The Assessment Of Acute Kidney Injury (Aki), David J. Kennedy, Phd, Joseph M. Chan, Dinkar Kaw, Md, Anand M. Ravindaran, Md, Shobha Ratnam, Md, Phd, Deepak Malhotra, Md, Phd, Joseph I. Shapiro Md

Marshall Journal of Medicine

Background: Urinalysis is an important component in the assessment of acute kidney injury (AKI). Proteonomics is a rapidly developing approach in the analysis of physiological states. Several techniques have been developed to screen for protein populations. In this regard SELDI-TOF is a technique based on mass spectroscopy that is being utilized in proteonomics research.

Methods:For this study, clean catch or catheterized urine was collected from normals (n=18) and patients referred to the renal service with AKI. Based upon urine and serum chemistries, clinical parameters, and microscopic urinalysis, the urines were separated into those consistent with prerenal azotemia (n=17) and acute …