Medicine and Health Sciences Commons^™

Alzheimer Disease Research In The 21st Century: Past And Current Failures, New Perspectives And Funding Priorities, Francesca Pistollato, Elan L. Ohayon, Ann Lam, Gillian R. Langley, Thomas J. Novak, David Pamies, George Perry, Eugenia Trushina, Robin S.B. Williams, Alex E. Roher, Thomas Hartung, Stevan Harnad, Neal D. Barnard, Martha Clare Morris, Mei-Chun Lai, Ryan Merkley, P. Charukeshi Chandrasekera

Experimentation Collection

Much of Alzheimer disease (AD) research has been traditionally based on the use of animals, which have been extensively applied in an effort to both improve our understanding of the pathophysiological mechanisms of the disease and to test novel therapeutic approaches. However, decades of such research have not effectively translated into substantial therapeutic success for human patients. Here we critically discuss these issues in order to determine how existing human-based methods can be applied to study AD pathology and develop novel therapeutics. These methods, which include patient-derived cells, computational analysis and models, together with large-scale epidemiological studies represent novel and …

An Ethogram For Benthic Octopods (Cephalopoda: Octopodidae), Jennifer Mather, Jean S. Alupay

Physiology Collection

The present paper constructs a general ethogram for the actions of the flexible body as well as the skin displays of octopuses in the family Octopodidae. The actions of 6 sets of structures (mantle–funnel, arms, sucker–stalk, skin–web, head, and mouth) combine to produce behavioral units that involve positioning of parts leading to postures such as the flamboyant, movements of parts of the animal with relation to itself including head bob and grooming, and movements of the whole animal by both jetting in the water and crawling along the substrate. Muscular actions result in 4 key changes in skin display: (a) …

Chronic Kidney Disease And Acute Myocardial Infarction: The Story After 1 Year, Paulette S. Wehner, William A. Nitardy

Internal Medicine

When chronic kidney disease (CKD) is part of the clinical history for a patient with acute myocardial infarction, the interventional cardiologist experiences an increased anxiety level. An acute myocardial infarction with renal disease requires more attention to dye load and fluid status, and general opinion exists regarding the negative outcomes of these “sicker” patients.

Mark Navarro and colleagues completed a thorough study from a different angle. We know the interventionalists’ concerns are justified acutely as these CKD patients have a higher level of inpatient complications, but these authors chose to look at the patients 1 year from their event to …

Esophageal Diagnosis Of A Malignant Aspergilloma, Muneer Al Zoby, Nancy Munn,, Yousef Shweihat

Internal Medicine

A 59-year-old male patient developed a new 4 cm × 6 cm cavitary left upper lung lesion over a 2 months period. The patient had a prior history of a surgically resected Stage IA non-small cell lung cancer in the right upper lobe 3 years prior. He was treated for possible infection with radiographic improvement on subsequent imaging. Further imaging after 3 months revealed an oval soft tissue density within the cavity with air crescent sign. Bronchoscopy with transbronchial biopsies showed an acute and chronic granulomatous inflammation. Aspergillus fumigatus was noted on culture and voriconazole was initiated. Subsequent imaging showed …

The Impact Of Alzheimer’S Disease In An Aging Rural Population, Lynne J. Goebel, Vivian M. Minkemeyer, Courtney Wellman

Internal Medicine

West Virginia already has a large elderly population, and it is expected to increase along with the elderly population of the nation as a whole. Since the most important risk factor for Alzheimer’s disease is older age, it is not surprising that the prevalence of Alzheimer’s disease is projected to increase significantly over the next thirty-five years. This paper discusses the prevalence of Alzheimer’s disease in West Virginia, programs available to assist people and caregivers affected by the disease, and the associated economic burden of the disease.

Rural Disparities In Cancer Care: A Review Of Its Implications And Possible Interventions, Raj Singh, Lynne J. Goebel Md

Internal Medicine

Cancer care has greatly improved in the last few decades, as evidenced by a 22% decline in the overall cancer-related death rate in the United States since 1991. However, the question presents itself whether rural residents, for whom the latest advancements are not as accessible, are also realizing these benefits as much as their urban counterparts. The aim of this study is to provide are view of the literature regarding the disparities in cancer care facing rural Appalachia and specifically West Virginia (WV) as well as possible solutions towards bridging this gap. We find that WV has a higher cancer …

Effectiveness And Feasibility Of In-Office Versus Smartphone Text-Delivered Nutrition Education In The College Setting: A Mixed-Methods Pilot Study, Jordan Rose, Deepika Goyal, Mary Ellen Wilkosz, Anita Catlin

Doctoral Projects

Often, being away from home for the first time, coupled with limited knowledge regarding healthy eating behaviors, leads to poor food choices and an increased risk of obesity among college-aged young adults. These college students are prone to high-calorie diets and limited physical activity, putting them at risk for obesity, a physiologically, psychologically, and financially costly epidemic in the United States. College students use their cellular phones over eight and a half hours a day and cell phones are their primary means of information consumption outside of the classroom, suggesting that the phones would be a useful tool to provide …

Creating Therapy Materials To Improve Communication Of Young Children, Allison J. Corey

Senior Honors Projects

Once children start preschool, they should be able to speak in simple sentences and use basic syntax. When they complete preschool and begin kindergarten, they should be using complete, complex sentences, have an extensive vocabulary, and use correct grammar. However, sometimes a child’s language doesn’t develop as expected resulting in speech delays or impairments. This problem could arise for a multitude of reasons, for example, the child may be on the autism spectrum, he/she may have a specific language delay, or it may be due to an articulation/phonology problem. The role of a speech language pathologist (SLP) in a school …

Information Technology Proposal For The Town Of Spencer, Vijay Basava, Corey Kenyon, Mahdi Soltani

School of Professional Studies

The Town of Spencer came to us looking for a plan to build and maintain their own personal fiber network for connection between departments and to improve data security for important information. After assessing the existing landscape and determining the various paths forward, we created network diagrams and plans for the movement forward of this project.

After assessing a variety of plans, we found that a full single-mode fiber network would be the best system for the implementation in Spencer. While it was the highest cost, it also scored the highest in our assessment.

Healthcare Facility Location: A Breast Cancer Alliance Case Study, Alexandra Knopf

Sustainability and Social Justice

Community health is impacted by the location of a health advocacy agency. This commissioned report for the Breast Cancer Alliance of Greenwich, CT, consists of a location analysis to review potential cities in which they might locate expansion efforts. Such cities include Boston, MA, Chicago, IL, Greenwich, CT, Los Angeles, CA, San Francisco, CA, and Washington, D.C. This report will look at five ways (4 mathematical and one spatial) of conducting a location analysis that require specialized knowledge for interpretation. For this study, a Spatial Geographic Information System methodology is preferred because of the visualization component, which can ensure that …

The Effect Of Descriptive Norms On Resistance Exercise Self-Efficacy In College-Aged Females 2016, Justin Kompf

Master's Theses

Resistance training is a form of physical activity that provides substantial health benefits. Despite these widespread benefits, participation in resistance training is considerably low, particularly among females. To engage in a skill-related activity such as resistance training, individuals need to have confidence in their abilities. Self-efficacy is a cognitive construct that is used to describe situation-specific self-confidence. Descriptive norms are a type of social norm that describes the behavior of others. Descriptive norms have been useful in positively changing health related behaviors. The exact mechanism of how descriptive norms alter behavior is unknown. However, it has been show in research …

Ssri Use In Pregnancy And Congenital Heart Defects: A Meta-Analysis Of Population Based Cohort Studies, Elizabeth A. Kowalik

Senior Honors Projects

The American College of Obstetricians and Gynecologists estimate that 10-23% of pregnant women in the US face depression at some point during their pregnancy. However, no clear recommendations regarding the treatment of depression in pregnancy are available. Antidepressants are commonly used during pregnancy without clear evidence of their safety. A study of 1,106,757 women in 47 states found that 89,980 (8.1%) had taken an antidepressant at some point during their pregnancy. The Centers for Disease Control and Prevention (CDC) found that 298 (4.5%) of 6582 women in 10 states between the years of 1998 and 2005 had taken an antidepressant …

Behavioral Interventions In Six Dimensions Of Wellness That Protect The Cognitive Health Of Community-Dwelling Older Adults: A Systematic Review, Kelley A. Strout, Daniel J. David, Elizabeth J. Dyer, Roberta C. Gray, Regula H. Robnett, Elizabeth P. Howard

Library Services Faculty Publications

OBJECTIVES: To systematically identify, appraise, and summarize research on the effects of behavioral interventions to prevent cognitive decline in community-dwelling older adults using a holistic wellness framework. DESIGN: Systematic review of randomized controlled trials that tested the effectiveness of behavioral interventions within each of the six dimensions of wellness: occupational, social, intellectual, physical, emotional and spiritual. Databases searched included PubMed MEDLINE, EMBASE, CENTRAL, PsycINFO, CINAHL, ALOIS, and The Grey Literature Report through July 1, 2014. SETTING: Community. PARTICIPANTS: Individuals aged 60 and older (N = 6,254). MEASUREMENTS: Consolidated Standards of Reporting Trials Checklist. RESULTS: Eighteen studies met the inclusion criteria. …

Characterization Of Bacterial Pathogens Involved In Aerobic Vaginitis: Prevalence, Strain Characterization And Sequelae, Leslie A. Lafferty

Graduate School of Biomedical Sciences Theses and Dissertations

Aerobic vaginitis (AV) is a more recently defined infection that involves aerobic pathogenic bacteria that replace the normal flora of the vaginal tract. It is commonly mistaken for other vaginal infections, such as bacterial vaginosis (BV), because they share many common symptoms. AV leads to complications during pregnancy, such as premature delivery and amnion infection, and is diagnosed by indications that range from vaginal discharge to inflammation. Because this infection is difficult to diagnose differentially from other vaginal infections, it is important to determine what pathogens are involved in AV so that we may have the ability to detect them. …

Developing An Online Database Of Experts For The Worcester Regional Chamber Of Commerce, Zikan Chen, Douglas Grey, Pranjal Shah

School of Professional Studies

The Worcester Regional Chamber of Commerce as part of their mission to attract business to the Worcester area, want to create an online searchable database of industry experts made up of faculty members of the Colleges and Universities in the Worcester area. This online database will be placed on the Worcester Regional Chamber of Commerce Higher Education – Business Partnership page on their website. The limitations placed on this request are that the Regional Chamber as of this moment have no monetary or Information Technologies resources to provide for the realization of this request.

The proliferation of as A Service …

Cybersecurity Awareness Shrewsbury Public Schools, Brittany Crompton, David Thompson, Manuel Reyes, Xueyan Zhao, Xueke Zou

School of Professional Studies

In the 21st Century, technology reaches every aspect of our lives. As “digital citizens” we must be aware of the dangers both to our technological equipment and our personal information stored, transmitted, and processed on this equipment. The Cybersecurity Awareness curriculum developed for the Shrewsbury Public School district is designed to meet this need, as well as foster an interest in technology and ethical computer use.

Analysis Of The Point Of Sales System At Tower Hill Botanical Garden And Suggested Courses Of Action, Brian Dunn, Keerthi Bandi, Chantal Kopwa Epse Kassa, F.N.U Shelly

School of Professional Studies

As Tower Hill Botanic Garden continues to improve on its operations and enhance the experience of its visitors and members, they are on a quest for a new Point-Of-Sale (POS) system that not only works with its existing hardware and interface with Raiser’s Edge, a smartcloud fundraising and relationship management software central to the garden’s operations but also, have a restaurant module and the capability of operating both in a wireless and hard-wired environment.

Sirtuins, Cell Senescence, And Vascular Aging, Yujiro Kida, Michael S. Goligorsky

NYMC Faculty Publications

The sirtuins (SIRTs) constitute a class of proteins with nicotinamide adenine dinucleotide-dependent deacetylase or adenosine diphosphate-ribosyltransferase activity. Seven SIRT family members have been identified in mammals, from SIRT1, the best studied for its role in vascular aging, to SIRT7. SIRT1 and SIRT2 are localized in the nucleus and cytoplasm. SIRT3, SIRT4, and SIRT5 are mitochondrial, and SIRT6 and SIRT7 are nuclear. Extensive studies have clearly revealed that SIRT proteins regulate diverse cell functions and responses to stressors. Vascular aging involves the aging process (senescence) of endothelial and vascular smooth muscle cells. Two types of cell senescence have been identified: (1) …

Differences Between Two Head Start Locations Using The Developmental Indicators For The Assessment Of Learning (Dial) As A Measure Of Language And Concepts, Hailey Guthrie

Rehabilitation, Human Resources and Communication Disorders Undergraduate Honors Theses

The study was conducted on a sample of 43 students between two Head Start locations, A and B. Sociodemographic information was obtained via questionnaires completed by parents at locations A and B. The Developmental Indicators for the Assessment of Learning, Fourth Edition (DIAL-4) was the screener used to assess each child’s performance with regards to language, concept, and motoric development. There was no significant difference between locations A and B for concept and language sub-test standard scores. DIAL motor sub-test scores for locations A and B were statistically significant. This study found that the DIAL is a reliable way to …

Evaluation Of Protein Source At Breakfast On Energy Metabolism, Metabolic Health, And Food Intake: A Pilot Study, Lauren A. Cambias

Human Nutrition and Hospitality Management Undergraduate Honors Theses

Abstract

Over 30% of adults in the US are obese. A primary contributor to obesity is an unhealthy diet related to imbalanced macronutrients. Diets higher in protein (PRO) are associated with increased energy expenditure (EE) and reduced food intake. The objective of this pilot study was to determine if protein source at breakfast influences EE in young men (n=4; ages 18-35). Participants consumed three isocaloric (whey (WP), pea (PP), beef (BP); 275 kcal, 62% PRO, 23% CHO, 15% Fat) drinks in randomized, crossover design with a one-week washout period. Each test day EE, appetite, and cravings were assessed at 0, …

A Clinical Decision Support System For Malignant Pleural Effusion Analysis, Troy J, Vargason, Joshua Cohn, David Rios, Olivia Schultz, Joseph Cleary, Dennis Lau, Walker Land, J. David Schaffer, Yinglei Li, Chun-An Chou, Saba A. Syouri, Jagmohan S. Sidhu, Martha F. Nelson, Xingye Qiao

Justice & Well-Being Studies Faculty Scholarship

Pleural effusion occurs when fluid accumulates in the pleural cavity surrounding the lung. This condition is commonly caused by infection, but can also be associated with the presence of a metastatic tumor. Samples of pleural fluid are used to analyze the morphologies of mesothelial cells and can typically be used to make a diagnosis between benignity and malignancy. Atypical pleural effusion samples are not easily identified as benign or malignant due to a lack of differentiable visual features, and such a problem has a significant influence in clinicians' decision making. In this paper, the goal is to develop a clinical …

Student's Assistance And Contribution To Their Community After Participating In An Emergency Prepardeness Inter-Professional Collaborative Practice Simulation, Elizabeth Scott, Ronda Chrstman, Sonia Wrate, Rebecca Retzer, Laura Racovita-Szilagyi, Cynthia Gettys, Brooks Kirschmann

Faculty Works

Poster presented at Teaching to Transform for the New Reality of Nursing Practice. The 12th Annual Nursing Faculty Development Workshop at University of Kentucky. Lexington, KY in May 2016.

Effect Of Glycemic Control On Infection In Post Total Joint Replacements In The Diabetic Patient, Sandra Hall

Nursing Capstones

No abstract provided.

Identification Of Protein Palmitoylation Inhibitors From A Scaffold Ranking Library, Laura D. Hamel, Brian J. Lenhart, David A. Mitchell, Radleigh Santos, Marc A. Giulianotti, Robert J. Deschenes

Mathematics Faculty Articles

The addition of palmitoyl moieties to proteins regulates their membrane targeting, subcellular localization, and stability. Dysregulation of the enzymes which catalyzed the palmitoyl addition and/or the substrates of these enzymes have been linked to cancer, cardiovascular, and neurological disorders, implying these enzymes and substrates are valid targets for pharmaceutical intervention. However, current chemical modulators of zDHHC PAT enzymes lack specificity and affinity, underscoring the need for screening campaigns to identify new specific, high affinity modulators. This report describes a mixture based screening approach to identify inhibitors of Erf2 activity. Erf2 is the Saccharomyces cerevisiae PAT responsible for catalyzing the palmitoylation …

Health Information Exchange: A Strategy For Improving Access For Rural Veterans In The Maine Flex Rural Veterans Health Access, Karen B. Pearson Mlis, Ma, Amanda Burgess Mppm, John A. Gale Ms, Andrew F. Coburn Phd, Anush Yousefian Hansen Ms, Ma

Access / Insurance

This paper reports on the design and implementation of a first-in-the nation project to expand rural veterans’ access to healthcare by establishing a bi-directional connection between Maine’s statewide health information exchange (HIE) and Veterans Administration facilities and centers. The paper reviews key factors that have contributed to implementation challenges and successes and lessons relevant to efforts to create interoperable health IT systems across multiple, complex organizational settings.

Improving Rural Bone Health And Minimizing Fracture Risk In West Virginia: Validation Of The World Health Organization Frax® Assessment Tool As A Phone Survey For Osteoporosis Detection, Franklin D. Shuler Md, Phd, Kelly Scott Md, Mph, Timothy Wilson-Byrne Md, Miranda R. Morgan, Linda Morgan

Orthopaedics

West Virginia ranks second nationally in population ≥ 65 years old placing our state at greater risk for osteoporosis and fracture. The gold standard for detecting osteoporosis is dual X-ray absorptiometry (DXA), yet over half of West Virginia’s counties do not have this machine. Due to access barriers, a validated phone-administered fracture prediction tool would be beneficial for osteoporosis screening. The World Health Organization’s FRAX® fracture prediction tool was administered as a phone survey to 45 patients; these results were compared to DXA bone mineral density determination. Results confirmed that the FRAX® phone survey is as reliable as DXA in …

Contingency Management Works, Clients Like It, And It Is Cost-Effective., Kimberly C. Kirby, Lois A Benishek, Mary B Tabit

College of Science & Mathematics Departmental Research

No abstract provided.

Global Deletion Of Panx3 Produces Multiple Phenotypic Effects In Mouse Humeri And Femora, Deidre Caskenette, Silvia Penuela, Vanessa Lee, Kevin Barr, Frank Beier, Dale W. Laird, Katherine E. Willmore

Anatomy and Cell Biology Publications

© 2016 Anatomical Society. Pannexins form single-membrane channels that allow passage of small molecules between the intracellular and extracellular compartments. Of the three pannexin family members, Pannexin3 (Panx3) is the least studied but is highly expressed in skeletal tissues and is thought to play a role in the regulation of chondrocyte and osteoblast proliferation and differentiation. The purpose of our study is to closely examine the in vivo effects of Panx3 ablation on long bone morphology using micro-computed tomography. Using Panx3 knockout (KO) and wildtype (WT) adult mice, we measured and compared aspects of phenotypic shape, bone mineral density (BMD), …

Music Therapy In Patients With Dementia And Behavioral Disturbance On An Inpatient Psychiatry Unit: Results From A Pilot Randomized Controlled Study., Joanna Thornley, Hussein Hirjee, Akshya Vasudev

Psychiatry Publications

The prevalence of dementia continues to grow worldwide due to an aging population and is projected to affect 65.7 million people by 2030 (World Health Organization, 2012). Behavioral and psychological symptoms of dementia (BPSD), including agitation, anxiety, aggression, depression, and psychosis, can occur in as much as 80% of the affected population, frequently necessitating psychiatric admission. Traditionally BPSD have been treated using pharmacological approaches. However, such medications could have serious adverse effects and additionally have limited efficacy in reducing such symptoms (Ballard et al., 2009).

Moving Towards A New Vision: Implementation Of A Public Health Policy Intervention, Ruta Valaitis, Marjorie Macdonald, Anita Kothari, Linda O’Mara, Sandra Regan, John Garcia, Nancy Murray, Heather Manson, Nancy Peroff-Johnston, Gayle Bursey, Jennifer Boyko

Health Studies Publications

Background

Public health systems in Canada have undergone significant policy renewal over the last decade in response to threats to the public’s health, such as severe acute respiratory syndrome. There is limited research on how public health policies have been implemented or what has influenced their implementation. This paper explores policy implementation in two exemplar public health programs -chronic disease prevention and sexually-transmitted infection prevention - in Ontario, Canada. It examines public health service providers’, managers’ and senior managements’ perspectives on the process of implementation of the Ontario Public Health Standards 2008 and factors influencing implementation.

Methods

Public health staff …