Medicine and Health Sciences Commons^™

The Role Of Bone Sialoprotein In The Tendon-Bone Insertion, Ryan Marinovich, Yohannes Soenjaya, Gregory Q. Wallace, Andre Zuskov, Andrew Dunkman, Brian L. Foster, Min Ao, Kevin Bartman, Vida Lam, Amin Rizkalla, Frank Beier, Martha J. Somerman, David W. Holdsworth, Louis J. Soslowsky, François Lagugné-Labarthet, Harvey A. Goldberg

Bone and Joint Institute

© 2016 International Society of Matrix Biology. Tendons/ligaments insert into bone via a transitional structure, the enthesis, which is susceptible to injury and difficult to repair. Fibrocartilaginous entheses contain fibrocartilage in their transitional zone, part of which is mineralized. Mineral-associated proteins within this zone have not been adequately characterized. Members of the Small Integrin Binding Ligand N-linked Glycoprotein (SIBLING) family are acidic phosphoproteins expressed in mineralized tissues. Here we show that two SIBLING proteins, bone sialoprotein (BSP) and osteopontin (OPN), are present in the mouse enthesis. Histological analyses indicate that the calcified zone of the quadriceps tendon enthesis is longer …

Development Of A Social Marketing Plan To Decrease Long Term Care Nurses Use Of Unnecessary Pharmacological Interventions To Address Residents' Behavioral Disturbances, Kela Spikes Bickham

Doctoral Projects

Seventy-six percent of long term care (LTC) residents display behavioral disturbances associated with psychiatric disorders, including dementia, which “often occur in clusters and include depression, psychosis, aggression, agitation, anxiety, and wandering” (Agency for Healthcare Research and Quality [AHRQ], 2014 para. 2; Perkins, 2012). Forty percent of LTC residents with behavioral disturbances receive pharmacological treatments to manage their behavioral disturbances, but these medications have limited efficacy and significant adverse effects (Gustafsson, Karlsson, & Lövheim, 2013). This remains important because the population, ages 65 and older (approximately 88% of all LTC residents), represent the most vulnerable to the effects of pharmacological interventions …

Review Of "Beyond The Abortion Wars". By Charles Camosy, M. Therese Lysaught

Institute of Pastoral Studies: Faculty Publications and Other Works

No abstract provided.

Multigene Panel Testing For Hereditary Cancer Risk, Alyssa Grissom, Patricia Friend

Nursing: School of Nursing Faculty Publications and Other Works

Historically, an understanding of a patient and/or their family’s cancer risk and predisposition was based in large part on patient pedigree or family history, histology, and age at diagnosis. However, since the completion of the Human Genome Project, advances in technology have moved from pedigree to single-gene testing to multigene testing and next-generation sequencing. Advanced practitioners need to follow developments in genetic testing to interpret results, ensure that their patients/families receive appropriate counseling before and after testing, understand the clinical impact of genetic testing across the trajectory of healthcare, including surveillance, screening, diagnosis, treatment, lifestyle, pharmacogenomics, and new targeted therapies. …

Optimizing The Teachable Moment For Health Promotion For Cancer Survivors And Their Families, Michelle Frazelle, Patricia J. Friend

Nursing: School of Nursing Faculty Publications and Other Works

No abstract provided.

Assessing Next-Generation Sequencing And 4 Bioinformatics Tools For Detection Of Enterovirus D68 And Other Respiratory Viruses In Clinical Samples, Weihua Huang, Guiqing Wang, Henry Lin, Jian Zhuge, Sheila M. Nolan, Eric Vail, Nevenka Dimitrova, John T. Fallon

NYMC Faculty Publications

We used 4 different bioinformatics algorithms to evaluate the application of a metagenomic shot-gun sequencing method in detection of Enterovirus D68 and other respiratory viruses in clinical specimens. Our data supported that next-generation sequencing, combined with improved bioinformatics tools, is practically feasible and useful for clinical diagnosis of viral infections.

Role Of Tumor Necrosis Factor Alpha (Tnf-A) In Hippocampal Neurodegeneration, Sara Shaaban Sharkawi Sayed

Pharmacology and Therapeutics Dissertations

Tumor necrosis factor alpha (TNF-a) is a proinflammatory cytokine with homeostatic and pathological roles in the central nervous system. The main objective of this dissertation is to study the impact of presence and absence of TNF-a on kainic acid (KA)-induced neurotoxicity at several time points (0.5 and 4 hr as well as 1, 3, 5, 15 and 30 days) to find out the possible mechanisms underlying its effects. KA (40mg/kg) was given intranasally to TNF-a knockout (Ko) mice and C57BL/6 wild-type (Wt) mice. Seizure severity was scored and behavioral tests including Elevated Plus-Maze (EPM), open-field, and Y-maze were performed. The …

Facilitating Effective Communication Between First Responders And Older Adults During Fall Incidents: An Educational Intervention, Krystin M. Beeman, Erica L. Berger, Isabel A. Cabezas, Nicole M. Mathews

Dissertations, Masters Theses, Capstones, and Culminating Projects

PURPOSE. The purpose of this project was to provide first responders with communication strategies for older adults that may help when responding to fall- related calls. General information was also provided to First Responders on working with older adults with a focus on the aging process, fall risk factors, and communications strategies.

METHODS. A series of educational sessions to first responders at a local fire district were developed and presented by occupational therapy students. Materials were developed by presenters from evidence-based resources and tailored to the target population. Each presentation focused on statistics about older adults, the aging process, fall …

Aquagenic Palmoplantar Keratoderma With Dorsal Hand Involvement In An Adolescent Female, Divya Angra, Kunal Angra, Ife J. Rodney

Dermatology Faculty Publications

Aquagenic palmoplantar keratoderma (APK) is a rare, acquired condition that presents as papules on the palms, and rarely the soles, upon immersion in water. We describe a patient who presented with the unusual finding of dorsal involvement of the hands.

Renal Stress Testing In The Assessment Of Kidney Disease, Lakhmir S. Chawla, Claudio Ronco

Anesthesiology and Critical Care Medicine Faculty Publications

As part of human evolutionary development, many human organ systems have innate mechanisms to adapt to increased “work demand” or stress. This reserve capacity can be informative and is used commonly in cardiology to assess cardiac function (e.g., treadmill test). Similarly, the kidney possesses reserve capacity, which can be demonstrated in at least 2 of the following renal domains: glomerular and tubular. When appropriate stimulants are used, healthy patients with intact kidneys can significantly increase their glomerular filtration rate and their tubular secretion. This approach has been used to develop diagnostics for the assessment of renal function. This article reviews …

Expert Opinion Regarding Invasive Monitoring: From Surface To Depth, Mohamad Z. Koubeissi

Neurology Faculty Publications

No abstract provided.

Exploring The Effect Of Novel Small Molecules On Oligodendrocyte Precursor Proliferation, Sagune Sakya

University Scholar Projects

Gliomas, a type of brain tumor, can be difficult to treat and have a poor survival rate. One pathway that leads to glioma formation is excessive signaling by platelet derived growth factors (PDGF) through PDGF receptor α (PDGFRα). Through this research, I found that novel compounds that downregulate PDGFRα decrease proliferation of Oli-neu cells, an oligodendrocyte precursor cell model, and identified signaling pathways through which these compounds may exert their effect. Further investigation may identify targets for development of glioma treatments.

Hypertonicity: Pathophysiologic Concept And Experimental Studies, Christos Argyropoulos, Helbert Rondon-Berrios, Dominic S. Raj, Deepak Malhotra, Emmanuel I. Agaba, +5 Additional Authors

Medicine Faculty Publications

Disturbances in tonicity (effective osmolarity) are the major clinical disorders affecting cell volume. Cell shrinking secondary to hypertonicity causes severe clinical manifestations and even death. Quantitative management of hypertonic disorders is based on formulas computing the volume of hypotonic fluids required to correct a given level of hypertonicity. These formulas have limitations. The major limitation of the predictive formulas is that they represent closed system calculations and have been tested in anuric animals. Consequently, the formulas do not account for ongoing fluid losses during development or treatment of the hypertonic disorders. In addition, early comparisons of serum osmolality changes predicted …

Mr Imaging Findings In Xp21.2 Duplication Syndrome, Matthew T. Whitehead, Guy Helman, Andrea L. Gropman

Radiology Faculty Publications

Xp21.2 duplication syndrome is a rare genetic disorder of undetermined prevalence and clinical relevance. As the use of chromosomal microarray has become first line for the work-up of childhood developmental delay, more gene deletions and duplications have been recognized. To the best of our knowledge, the imaging findings of Xp21.2 duplication syndrome have not been reported. We report a case of a 33 month-old male referred for developmental delay that was found to have an Xp21.2 duplication containing IL1RAPL1 and multiple midline brain malformations.

The Presence Of Pressure Ulcer Documentation On Admission, Kelsey Horton, Savannah Peterman, Whitney Walters, Charles Rogers

Celebration of Student Scholarship Poster Sessions Archive

No abstract provided.

Post-Operative Bleeding In Greyhound Dogs Using An Abbreviated Aminocaproic Acid Treatment Protocol, Courtney Hamblin, Kimberly Peterson

Celebration of Student Scholarship Poster Sessions Archive

No abstract provided.

Detecting Cardio-Respiratory Instability In Neonates, Joshua Todd Carroll, Shahrokh Sani

Celebration of Student Scholarship Poster Sessions Archive

No abstract provided.

Nurses' Knowledge Of Eating Disorders, Carly S. Price

Undergraduate Honors Theses

Eating Disorders are a range of disorders marked by abnormal eating habits. These habits can often have a detrimental effect on the body and have the potential to complicate acute medical problems if they are a pre-existing condition. Due to this, it is important that members of the healthcare team be aware of the nature of these disorders from both a physical and mental health perspective in order to provide the best, most holistic care. In this study, individuals with nursing experience in acute medical and acute psychiatric care were asked 11 questions concerning the assessment and knowledge of eating …

Cd4 T Cell-Derived Ifn-Γ Plays A Minimal Role In Control Of Pulmonary Mycobacterium Tuberculosis Infection And Must Be Actively Repressed By Pd-1 To Prevent Lethal Disease, Shunsuke Sakai, Keith D. Kauffman, Michelle A. Sallin, Arlene H. Sharpe, Howard A. Young, Vitaly V. Ganusov, Daniel L. Barber

United States Public Health Resources

IFN-γ–producing CD4 T cells are required for protection against Mycobacterium tuberculosis (Mtb) infection, but the extent to which IFN-γ contributes to overall CD4 T cell-mediated protection remains unclear. Furthermore, it is not known if increasing IFN-γ production by CD4 T cells is desirable in Mtb infection. Here we show that IFN-γ accounts for only ~30% of CD4 T cell-dependent cumulative bacterial control in the lungs over the first six weeks of infection, but >80% of control in the spleen. Moreover, increasing the IFN-γ–producing capacity of CD4 T cells by ~2 fold exacerbates lung infection and leads to the early death …

The Emergence Of Systematic Review In Toxicology, Martin L. Stephens, Kellyn Betts, Nancy Beck, Vincent Cogliano, Kay Dickersin, George Gray, +8 Additional Authors

Environmental and Occupational Health Faculty Publications

The Evidence-based Toxicology Collaboration hosted a workshop on “The Emergence of Systematic Review and Related Evidence-based Approaches in Toxicology,” on November 21, 2014 in Baltimore, Maryland. The workshop featured speakers from agencies and organizations applying systematic review approaches to questions in toxicology, speakers with experience in conducting systematic reviews in medicine and healthcare, and stakeholders in industry, government, academia, and non-governmental organizations. Based on the workshop presentations and discussion, here we address the state of systematic review methods in toxicology, historical antecedents in both medicine and toxicology, challenges to the translation of systematic review from medicine to toxicology, and thoughts …

Enhancing Access To Alcohol Use Disorder Pharmacotherapy And Treatment In Primary Care Settings: Adapt-Pc, Hildi J. Hagedorn, Randall Brown, Michael Dawes, Eric Diepernick, Donald Myrick, Elizabeth M. Oliva, Todd H. Wagner, Jennifer P. Wisdom, Alex Harris

Health Policy and Management Faculty Publications

Background: Only 7.8% of individuals meeting diagnostic criteria for alcohol use disorder (AUD) receive treatment in a given year. Most individuals with AUDs are identified in primary care (PC) settings and referred to substance use disorders (SUD) clinics; however, only a minority of those referred attend treatment services. Safe and effective pharmacological treatments for AUD exist, but they are rarely prescribed by PC providers. The objective of this study is to refine, implement, and evaluate an intervention to integrate pharmacological AUD treatment options into PC settings. This paper provides a detailed description of the intervention design and the evaluation components. …

Conversational Alignment: A Study Of Neural Coherence And Speech Entrainment, Kristen M. Jensen, Stephanie A. Borrie, Breanna E. Studenka, Ronald B. Gillam

All Graduate Plan B and other Reports, Spring 1920 to Spring 2023

Conversational alignment refers to the tendency for communication partners to adjust their verbal and non-verbal behaviors to become more like one another during the course of human interaction. This alignment phenomenon has been observed in neural patterns, specifically in the prefrontal areas of the brain (Holper et al., 2013; Cui et al., 2012; Dommer et al., 2012; Holper et al., 2012; Funane et al., 2011; Jiang et al., 2012); verbal behaviors such acoustic speech features (e.g., Borrie & Liss, 2014; Borrie et al., 2015; Lubold & Pon-Barry, 2014), phonological features (e.g., Babel, 2012; Pardo, 2006), lexical selection (e.g., Brennan & …

Interrupted Aortic Arch Complicated With Takotsubo Cardiomyopathy Mimicking Aortic Dissection, Farhala Mari Baloch, Javed Majid Tai, Aamir Hameed, Abdul Baqi

Section of Cardiology

A 50-year-old man presented to the emergency department with interscapular pain, diaphoresis and restlessness. Initial examination raised the possibility of aortic dissection; however, the CT scan did not concur with the diagnosis. An ECG showed ST segment elevation in leads V1-V6 and echocardiography showed severe left ventricular systolic dysfunction. Coronary angiography through the right femoral artery was attempted but the diagnostic catheter could not be advanced to the ascending aorta. Radiocontrast injection showed complete obstruction of the descending aorta. Coronary angiography through right radial approach showed mild left anterior descending disease. The aortogram showed complete interruption of the ascending aorta …

Studies On The Prevalence And Control Of Parasitic Helminths In "Natural" Laying Hens, Brittany R. Weir

Animal Science Undergraduate Honors Theses

One societal trend that has been gaining much traction and popularity since the 21^st century began is “organic” and/or “natural” food products. In 1999, the global market accounted for $15.2 billion dollars worth of organic food and drink, compared to the market in 2014 where we consumed $80 billion dollars worth (Willer et. al, 2016). With “natural” production of food animals however, “natural” parasite transmission may be a consequence. To that end, this experiment examines the prevalence of helminths in 110 “natural” laying hens from three regional farms and the efficacies of fenbendazole, piperazine, and levamisole on what should …

Aging American Prisons: Length Of Stay, Dying Behind Bars, And Implications For Public Health, Stephanie G. Barger

Sociology and Criminology Undergraduate Honors Theses

One notable consequence of mass incarceration is the growing population of elderly prison inmates in the U.S. This growth raises questions concerning the causes and implications of such a change, as housing older prisoners places a financial strain on state and federal correctional systems. Because this added cost is largely a result of medical needs, the growing elderly inmate population has raised questions about the impact of incarceration on health. This study investigates the causes of this “graying” of American prisons and its potential effects on correctional and community health. Using National Corrections Reporting Program data from 1990 to 2009, …

Current State Of Opioid Therapy And Abuse, Laxmaiah Manchikanti, Adam M. Kaye, Alan David Kaye

School of Pharmacy Faculty Articles

Currently, there is growing tension between the twin challenges of opioid therapy for chronic pain and adverse consequences of abuse, leading to multiple complications including respiratory failure and death. The recent data from Centers for Disease Control and Prevention (CDC) have shown continued escalation of prescription opioid use with opioid overdose deaths topping all previous estimations. Numerous policy initiatives, advisories, and guidelines have been advanced through the years to control the opioid epidemic. The strategies to prevent opioid abuse and to maintain opioid therapy when medically necessary fall into primary and secondary prevention categories. The primary prevention category is extremely …

Assessing Cultural Competence In A Mental Health Outpatient Facility., Alexis N. Keen Crook

Electronic Theses and Dissertations

Cultural competence is a concept that has been thoroughly investigated in healthcare, but there is a dearth of literature and research on this topic as it pertains to mental health services. In healthcare, research has shown that a lack of cultural competence is directly linked to high levels of misdiagnoses, mistrust of healthcare and professionals, and overall poor health in minority populations. Using the Campinha-Bacote model for cultural competence in health care, I explore how cultural competence is defined and operationalized in an outpatient mental health facility. I hypothesize that, similar to research addressing cultural competency in healthcare systems, cultural …

Impact Of Epigallocatechin-3-Gallate (Egcg), A Broad-Spectrum Anti-Inflammatory, In Controlling Intestinal Factors Contributing To Inflammatory Bowel Disease., Gerald Wayne Dryden, Jr.

Electronic Theses and Dissertations

This dissertation explores the role of epigallocatechin-3-gallate (EGCG), as a potential treatment for patients with inflammatory bowel disease (IBD). IBD is a common disorder that causes a great deal of suffering. Our understanding of the etiologies, pathogenic mechanisms, and treatment targets continues to evolve. Many new therapeutic targets are making their way through the pharmaceutical pipelines. However, not all patients benefit from these therapies. EGCG has long been studied as an anti-cancer agent. Most of our understanding of this compound comes from the oncologic literature. As the pathways of oncology and inflammation converge, new lessons can be taken from the …

Objective Evaluation Of Clinical Shade-Matching Outcomes., Erin Ballard

Electronic Theses and Dissertations

The purpose of this study was to objectively evaluate shade-matching outcomes within an academic institution. Using the Spectrophotometer, E was calculated between the reference shade: restoration shade () and restoration shade: prescription shade (). The t-test was used to determine if E maintained clinical acceptance at E: 3.7. Satisfaction with shade-match and need for objective measurement were surveyed using a Five Point Likert Scale. Correlational relationships were assessed via Pearson Correlation. Mean E values were above the acceptance value (pppp

Leveling The Playing Field Through Partnerships And Collaboration : Neighborhood Revitalizations And The Influence Of Social Determinants Of Health And Institutional Logics., J. M. Bohn

Electronic Theses and Dissertations

A qualitative study guided by grounded theory was on a Midwest US city (population > 50,000 people), three of its inner city neighborhoods, and community coalition and partnership efforts in neighborhood revitalizations. A two-phase semi-structured interview methodology assessed interviewees’ experiences in initiatives focused on improving social determinants of health in the neighborhoods. Phase I interviews (n= 11) identified the spectrum of partnerships and initiatives while Phase II interviews (n=28) captured detailed experiences of interviewees. Inter-institutional systems and institutional logics theory were applied in the post-data collection analysis. Interviewees were from public and private sectors including: built environment, economic development, residential/commercial property …