Medicine and Health Sciences Commons^™

A Lifetime Of Healthy Living: Unifying Awareness Of Healthy Living Among Appalachia's Diversified Community, Kyle M. Smith, Joy L. Gritton

Celebration of Student Scholarship Poster Sessions Archive

No abstract provided.

Ischemic Stroke Induces Gut Permeability And Enhances Bacterial Translocation Leading To Sepsis In Aged Mice, Venugopal Reddy Venna, Joshua Crapser, Rodney Ritzel, Rajkumar Verma, Fudong Liu, Anjali Chauhan, Edward Koellhoffer, Austin Ricker, Kendra Maas, Joerg Graf, Louise D. Mccullough

UCHC Articles - Research

Aging is an important risk factor for post-stroke infection, which accounts for a large proportion of stroke-associated mortality. Despite this, studies evaluating post-stroke infection rates in aged animal models are limited. In addition, few studies have assessed gut microbes as a potential source of infection following stroke. Therefore we investigated the effects of age and the role of bacterial translocation from the gut in post-stroke infection in young (8-12 weeks) and aged (18-20 months) C57Bl/6 male mice following transient middle cerebral artery occlusion (MCAO) or sham surgery. Gut permeability was examined and peripheral organs were assessed for the presence of …

Recreational Participation And Perceived Stress Levels Of College Students And If Leisure Satisfaction Mediates Their Relationship, Andrew Montgomery

Graduate Theses

The purpose of this study was to examine the relationship between campus recreation participation and perceived stress in college students and if leisure satisfaction mediates their relationship. Participants for this research were 342 college students at a southeastern university. Students completed a survey about their demographics, perceived stress (PSS-10), campus recreation participation and their leisure satisfaction (LSS). Correlations and mediation was then calculated using the statistical analysis program SPSS. Participants of recreational services perceived stress was not significantly correlated with students who do not use recreational services. Leisure satisfaction was inversely correlated with perceived stress in the participants. Out of …

Progression Magazine, 2016 Spring, Coastal Carolina University

Progression Magazine

Magazine of the College of Science at Coastal Carolina University.

Alcohol Consumption As A Risk Factor For Sarcopenia - A Meta-Analysis, M. Steffl, R. W. Bohannon, M. Petr, E. Kohlikova, I. Holmerova

Physical Therapy

No abstract provided.

Place Events 2015-2016, Place

PLACE Historical Documents

This document describes PLACE events at Linfield College for 2015-2016.

Medical Education Digest, Vol. 18 No. 3 (May-June 2016) Final Issue, Nova Southeastern University

Medical Education Digest

No abstract provided.

Effect Of Peritoneal Dialysis On Weight Change In Pediatric Patients, Lindsey Belliveau

Yale School of Medicine Physician Associate Program Theses

Obesity is associated with lower transplantation rate and higher mortality in pediatric end stage renal disease patients. Glucose-based peritoneal dialysis is the preferred method of dialysis for these patients, a therapy that can cause systemic glucose absorption. It is unknown whether this absorption leads to weight change in pediatric patients. We propose to examine whether Peritoneal Dialysis is associated with weight change in pediatric End Stage Renal Disease patients. We will prospectively observe a cohort of children aged 2-17 who are starting peritoneal dialysis. We will measure weight change after one year of dialysis, and compare these measurements to historical …

Iron Intake In Children With Attention-Deficit/Hyperactivity Disorder And Restless Legs Syndrome, Olivia Rojas

Yale School of Medicine Physician Associate Program Theses

Growing evidence supports an association between attention-deficit/hyperactivity disorder (ADHD) and restless legs syndrome (RLS) in children. Prior research suggests that in some patients iron deficiency is an underlying cause of pathological changes in the dopaminergic system of the brain that modulates these disorders. However, the underlying cause of such iron deficiency has not yet been identified. We propose to determine the prevalence of low serum ferritin levels, a marker of reduced iron stores, in children with comorbid ADHD and RLS, and if diet is associated with their diagnosis and observed blood iron levels. A case-control study will examine a sample …

Medical School Watercooler Newsletter - May 1, 2016, Lindsey Lyle

Watercooler Newsletter

This is the May 1, 2016 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents Include:

• 'I'm Ready for My Next Adventure:' USA Medical Student Finds Opportunities to Serve Others
• Pediatrics Hosting Grand Rounds May 20
• May Med School Café - 'Stressed Out? When to See Your Doctor'
• Students and Faculty to be Honored at Annual Honors Convocation

Lateral Violence Among New Graduate Nurses, Megan Russell

Nursing Theses and Capstone Projects

Lateral violence is an act of aggression that is committed against one nurse by another. There are many names for lateral violence, some of these include: horizontal violence, bullying, aggression, horizontal hostility, verbal abuse, or nurses eating their young. Lateral violence occurs when nurses covertly or overtly direct the dissatisfaction they are feeling inward toward each other. The effects of lateral violence on new graduate nurses and the organizations in which they work can be detrimental. An extensive literature review was undertaken to understand the significance and prevalence of lateral violence against new graduate nurses. The purpose of this study …

Mindfulness Education For Stress Reduction In Nursing Students, Kathryn Kekenes Peterson

Nursing Theses and Capstone Projects

Problem. The level of stress experienced by college students can be significant. It can be even more pronounced in nursing students as a result of the intense curriculum and clinical experiences. Stress can be the result of academic, personal, or interpersonal causes. It can affect physical, psychological, spiritual, and social well-being. Stress is not always avoidable but learning techniques to manage stress can improve overall well-being by decreasing the physical, psychological, spiritual, and social effects of stress. Learning to manage stress through holistic self-care with mindfulness stress reduction techniques could help alleviate the negative effects of stress, enabling the student …

Proper Technique When Administering Intramuscular Injections, Ashley M. Isaac-Dockery

Nursing Theses and Capstone Projects

The intent of the evidence-based practice project was to implement a policy change requiring licensed nurses employed by a local rural healthcare organization to complete an educational module on correct intramuscular (IM) administration technique. During the 2014 influenza season, injuries were noted to employees who received influenza vaccinations within the healthcare organization. The injuries occurred after licensed nurses employed by the healthcare organization administered the influenza injection incorrectly to other employees. Injuries were noted after the influenza injection was administered too high in the deltoid causing injury to the shoulder joint. A corrective action plan was developed by a doctoral …

Practical Pearl: Iron Deficiency Anemia - May 2016, Joanna Luty Md

Pediatrics Practical Pearls: Referral Guidelines for Common Problems

No abstract provided.

Role Of Chemokine Rantes In The Regulation Of Perivascular Inflammation, T-Cell Accumulation, And Vascular Dysfunction In Hypertension., Tomasz P Mikolajczyk, Ryszard Nosalski, Piotr Szczepaniak, Klaudia Budzyn, Grzegorz Osmenda, Paul J. Marvar, +10 Additional Authors

Pharmacology and Physiology Faculty Publications

Recent studies have emphasized the role of perivascular inflammation in cardiovascular disease. We studied mechanisms of perivascular leukocyte infiltration in angiotensin II (Ang II)-induced hypertension and their links to vascular dysfunction. Chronic Ang II infusion in mice increased immune cell content of T cells (255 ± 130 to 1664 ± 349 cells/mg; P < 0.01), M1 and M2 macrophages, and dendritic cells in perivascular adipose tissue. In particular, the content of T lymphocytes bearing CC chemokine receptor (CCR) 1, CCR3, and CCR5 receptors for RANTES chemokine was increased by Ang II (CCR1, 15.6 ± 1.5% vs. 31 ± 5%; P < 0.01). Hypertension was associated with an increase in perivascular adipose tissue expression of the chemokine RANTES (relative quantification, 1.2 ± 0.2 vs. 3.5 ± 1.1; P < 0.05), which induced T-cell chemotaxis and vascular accumulation of T cells expressing the chemokine receptors CCR1, CCR3, and CCR5. Mechanistically, RANTES(-/-) knockout protected against vascular leukocyte, and in particular T lymphocyte infiltration (26 ± 5% in wild type Ang II vs. 15 ± 4% in RANTES(-/-)), which was associated with protection from endothelial dysfunction induced by Ang II. This effect was linked with diminished infiltration of IFN-γ-producing CD8(+) and double-negative CD3(+)CD4(-)CD8(-) T cells in perivascular space and reduced vascular oxidative stress while FoxP3(+) T-regulatory cells were unaltered. IFN-γ ex vivo caused significant endothelial dysfunction, which was reduced by superoxide anion scavenging. In a human cohort, a significant inverse correlation was observed between circulating RANTES levels as a biomarker and vascular function measured as flow-mediated dilatation (R = -0.3, P < 0.01) or endothelial injury marker von Willebrand factor (R = +0.3; P < 0.01). Thus, chemokine RANTES is important in the regulation of vascular dysfunction through modulation of perivascular inflammation.-Mikolajczyk, T. P., Nosalski, R., Szczepaniak, P., Budzyn, K., Osmenda, G., Skiba, D., Sagan, A., Wu, J., Vinh, A., Marvar, P. J., Guzik, B., Podolec, J., Drummond, G., Lob, H. E., Harrison, D. G., Guzik, T. J. Role of chemokine RANTES in the regulation of perivascular inflammation, T-cell accumulation, and vascular dysfunction in hypertension.

A Conserved Dna Repeat Promotes Selection Of A Diverse Repertoire Of Trypanosoma Brucei Surface Antigens From The Genomic Archive., Galadriel Hovel-Miner, Monica R. Mugnier, Benjamin Goldwater, George A. M. Cross, F. Nina Papavasiliou

Microbiology, Immunology, and Tropical Medicine Faculty Publications

African trypanosomes are mammalian pathogens that must regularly change their protein coat to survive in the host bloodstream. Chronic trypanosome infections are potentiated by their ability to access a deep genomic repertoire of Variant Surface Glycoprotein (VSG) genes and switch from the expression of one VSG to another. Switching VSG expression is largely based in DNA recombination events that result in chromosome translocations between an acceptor site, which houses the actively transcribed VSG, and a donor gene, drawn from an archive of more than 2,000 silent VSGs. One element implicated in these duplicative gene conversion events is a DNA repeat …

A Conserved Dna Repeat Promotes Selection Of A Diverse Repertoire Of Trypanosoma Brucei Surface Antigens From The Genomic Archive., Galadriel Hovel-Miner, Monica R Mugnier, Benjamin Goldwater, George A M Cross, F Nina Papavasiliou

Microbiology, Immunology, and Tropical Medicine Faculty Publications

African trypanosomes are mammalian pathogens that must regularly change their protein coat to survive in the host bloodstream. Chronic trypanosome infections are potentiated by their ability to access a deep genomic repertoire of Variant Surface Glycoprotein (VSG) genes and switch from the expression of one VSG to another. Switching VSG expression is largely based in DNA recombination events that result in chromosome translocations between an acceptor site, which houses the actively transcribed VSG, and a donor gene, drawn from an archive of more than 2,000 silent VSGs. One element implicated in these duplicative gene conversion events is a DNA repeat …

A Single Exercise Bout Enhances The Manufacture Of Viral-Specific T-Cells From Healthy Donors: Implications For Allogeneic Adoptive Transfer Immunotherapy, Guillaume Spielmann, Catherine Bollard, Hawley Kunz, Patrick J. Hanley, Richard J. Simpson

Pediatrics Faculty Publications

Cytomegalovirus (CMV) and Epstein-Barr virus (EBV) infections remain a major cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation (HSCT). The adoptive transfer of donor-derived viral-specific cytotoxic T-cells (VSTs) is an effective treatment for controlling CMV and EBV infections after HSCT; however, new practical methods are required to augment the ex vivo manufacture of multi-VSTs from healthy donors. This study investigated the effects of a single exercise bout on the ex vivo manufacture of multi-VSTs. PBMCs isolated from healthy CMV/EBV seropositive participants before (PRE) and immediately after (POST) 30-minutes of cycling exercise were stimulated with CMV (pp65 and …

Omics Strategy Discoveries To Obesity In The Prevention And Personalized Therapy, Hong-Duck Kim, M L. Carpenter, Diane E. Heck

NYMC Faculty Publications

No abstract provided.

Career Services Focus: Surgery, Boonshoft School Of Medicine Career Services

Department of Surgery Faculty Publications

A seven page newsletter from the Boonshoft School of Medicine's Career Services highlighting interviews with Department of Surgery faculty and students.

Spinal Cord Compression Secondary To Extramedullary Hematopoiesis: Case Report And Review Of The Literature, Arthur Wang, Nathan Carberry, Elena Solli, John Gillick, Humayun Islam, Virany Hillard

NYMC Faculty Publications

Extramedullary hematopoiesis (EMH) is a rare cause of spinal cord compression (SCC). EMH represents the growth of blood cells outside of the bone marrow and occurs in a variety of hematologic illnesses, including various types of anemia and myeloproliferative disorders. Although EMH usually occurs in the liver, spleen, and lymph nodes, it may also occur within the spinal canal. When this occurs, the mass effect can compress the spinal cord, potentially leading to the development of neurological deficits. We present a case of SCC secondary to EMH. This report illustrates the importance of considering EMH in the differential diagnosis of …

Chhs May 2016 Icymi, Dr. John Bonaguro, Dean, Vashon S. Wells, Editor, Wku College Of Health & Human Services

College of Health & Human Services Publications

No abstract provided.

Perceptions Fathers Have On Time Spent With Preschool Children And Its Impact On Language Outcome Measures, Megan E. Porter

Rehabilitation, Human Resources and Communication Disorders Undergraduate Honors Theses

Research has shown there are differences between mother and father language usage with their children. There is no information on language use of fathers who spend a high quality amount of time with their children. This study attempted to identify language characteristics of fathers who report high participation in household and childcare activities.

Outcomes In Language And Social Skills As Seen In Children With Autism And Developmental Disabilities Participating In Equine Assisted Activities, Megan Koenigseder

Rehabilitation, Human Resources and Communication Disorders Undergraduate Honors Theses

Individuals with developmental disabilities commonly present characteristics that include deficits in social and communicative abilities. A number of intervention strategies have been implemented, but none have proven to be most effective. A somewhat novel approach known as equine assisted activities and therapies (EAAT) involves the utilization of horses during intervention and has shown to be effective in areas concerning quality of life, social functioning, self-regulation, adaptive behaviors, motor control, and motivation.

The purpose of the current study is to examine the effects of EAA on social skills and expressive language in 2-4 children diagnosed with developmental disability. Participants engaged in …

The Effect Of Purposeful Hourly Rounding On The Incidence Of Patient Falls, Crista H. Brown

Nursing Theses and Capstone Projects

The purpose of this study was to evaluate the effectiveness of purposeful hourly rounding on the incidence of patient falls. Purposeful hourly rounding is a vital component of the nursing care delivery model that is impacting the fall rates. Providing structure and emphasis to the hourly rounding process assist in the evaluation of the desired outcomes as it relates to patients falls. As healthcare organizations experience the concept of public reporting, patient safety has become an increasingly important concern. Purposeful hourly rounding can improve quality, safety, and the patient’s perception of their care. The results of this study found there …

Pre-Employment Testing To Improve Nurse Retention, Jonathan Brandon

Nursing Theses and Capstone Projects

Nurse retention is an issue healthcare organizations cannot afford to ignore. The nursing shortage continues to impact healthcare in this country which increases the importance and urgency of retaining nurses. Job success, also referred as job satisfaction, is a key indicator of a nurse’s intent to stay. There are pre-employment tests that were designed specifically for healthcare organizations to help them choose applicants that are most likely to be successful resulting in better patient outcomes and improved nurse retention. The purpose of this study was to compare the perceived job satisfaction and intent to stay of nurses that completed pre-employment …

Orientation Program For Psychiatric Clinical Experience, Kathy C. Williams

Nursing Theses and Capstone Projects

Student nurses often experience anxiety prior to their psychiatric clinical experience and this anxiety can adversely affect their learning experience and ability to provide optimal nursing care to clients who have psychiatric illnesses. A formal Orientation Program for the Psychiatric Clinical Experience (OP-PCE) was developed to reduce student nurses’ anxiety prior to their psychiatric clinical experience. The OP-PCE was implemented as a component of the routine psychiatric curriculum in a pre-licensure registered nursing program at a university in Southeastern United States of America. Thirty-four student nurses participated in the OP-PCE. The content of the OP-PCE included general orientation information such …

Preprocedure Warming To Prevent Intraoperative Hypothermia, Kathy C. Anders

Nursing Theses and Capstone Projects

Maintaining homeostasis during surgery is vital to preserving health and preventing postoperative complications. Research supports the benefits of preprocedure warming in preventing or reducing intraoperative hypothermia. Better postoperative outcomes are linked to intraop normothermia such as a reduction in the occurrence of surgical site wound infection, reduced bleeding, and faster recovery from anesthetics. However there were barriers to prewarming at the researcher’s institution such as cost, convenience, and compliance. The purpose of this research project was to study the impact of prewarming in the high risk population of surgical spine fusion patients. The researcher also hoped to examine and raise …

Evidence-Based Obstetric Emergency Team Training And Drills, Michelle R. Cox

Nursing Theses and Capstone Projects

Obstetrical emergencies occur in less than two percent of all pregnancies in the United States. These emergency situations are unanticipated and occur rapidly. According to the American Congress of Obstetricians and Gynecologists, the most common obstetric emergencies in the United States are postpartum hemorrhage and shoulder dystocia. When these emergency medical situations occur, the entire medical team should respond immediately with precision and confidence. There is evidence to support planning and collaboration of interdisciplinary teams with ongoing education and training, leading to prompt recognition and response to critical situations, which can ultimately mitigate poor outcomes during obstetric emergencies. This capstone …

Rekindling The Passion For Nursing, Susan M. Cannon

Nursing Theses and Capstone Projects

Nurses often experience compassion fatigue and burnout when working in stressful environments. Nurses tend to put the needs of their patients above their own needs. It is imperative for the work environment to promote relaxation and restoration, to avert compassion fatigue and nursing burnout. All employees of the project director’s organization were encouraged to attend Caring for the Caregiver Day, a hospital-sponsored event which provided education and promoted self-help interventions aimed to decrease compassion fatigue and burnout. The event included aromatherapy, music therapy, art therapy, pet therapy, massage therapy, and education on compassion fatigue for nurses. In addition, the Progressive …