Medicine and Health Sciences Commons^™

Event Agenda, Lehigh Valley Health Network

Faculty Development

No abstract provided.

Development Of A Surgical Instrument Prototype To Perform A More Precise Capsulorhexis, Kirk Haugen

Journal of Interdisciplinary Undergraduate Research

Performing capsulorhexis is often considered the most difficult part of cataract surgery. Not only is it difficult, but performing it correctly is important for refractive outcomes.⁴ Inaccurate capsulorhexes are associated with complications including posterior capsular opacification, capsular fibrosis, and capsular phimosis.⁶ This study investigates the possibility of a proposed surgical instrument producing more precise capsulorhexes as determined by the circularity index. 60 capsulorhexes were performed on cigarette paper laid over clay - half using the continuous curvilinear capsulorhexis (CCC) method, and half using the proposed instrument. The precision of the capsulorhexis was then measured using the circularity index. …

Innovative Synthesis Of Diltiazem/Clentiazem Analogs, Emelyn Magtanong

Journal of Interdisciplinary Undergraduate Research

Cardiovascular disease defines disorders of the heart and blood vessels, and is the number one cause of death in America. Diltiazem and clentiazem are common calcium channel blockers incorporated into drugs used to treat various cardiovascular diseases. Methods to synthesize 5-[2-(dimethylamino)ethyl]-8-hydroxy-2,3,4,5-tetrahydro-1,5-benzothiazepin-4-one, an analog of the core of diltiazem and clentiazem, using cost-efficient starting materials allows for affordable treatment and increased availability to affected individuals. N-(N,N-dimethylethanamine)-4-aminophenol can be oxidized to form a quineoneimine, which can be further reacted with 3-mercaptopropionic acid via Michael addition. Subsequent addition of a coupling reagent, N,N'-dicyclocarbodiimide (DCC),¹ produces 5-[2-(dimethylamino)ethyl]-8-hydroxy-2,3,4,5-tetrahydro-1,5-benzothiazepin-4-one, analogous to the core …

Inhibiting Fatty Acid Synthase In Rapidly Dividing Cells: Synthesis Of 5-(Alkylthio)-1h-Benzo[D]Imidazole-2,6-Diones, Andy Hausted

Journal of Interdisciplinary Undergraduate Research

Prostate and breast cancer are the number one and number two cancer sites, respectively, for male and females within the United States.1 Increased levels of the enzyme fatty acid synthase have been found in rapidly dividing cancer cells. This enzyme is responsible for the de novo synthesis of fatty acids in human cells, which are essential to cell growth and survival. The goal then for this research is to synthesize and design a new synthesis of 5-(alkylthio)-1Hbenzo[ d]imidazole-2,6-diones intended to successfully inhibit fatty acid synthase (FASN) by binding allosterically to the thioesterase domain of FASN. Thus by selectively inhibiting FASN …

Effect Of Bisphenol-A On Neurodevelopment In Drosophila Melanogaster Larvae, Alexandra M. Streifel

All College Thesis Program, 2016-2019

This paper examines the effects of the chemical preservative bisphenol-A on the developing nervous systems of Drosophila melanogaster, or fruit fly, larvae. This study examines the effects of bisphenol-A using both behavioral as well as morphological paradigms. It was determined that bisphenol-A significantly increased the amount of time larvae spent in seeking behavior, the number of peristaltic contractions, and the distance traveled in a linear fashion. In the morphological analysis, indications of increased dendritic area in experimental larvae existed, but there was not enough data to determine significance. For future research, it is recommended that more data be gathered to …

Ada News - 05/02/2016, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Week Of May 2, 2016, New York Medical College

InTouch

• BioInc@NYMC Encourages Entrepreneurial Spirit at Pitching to the Angels Event
• Department of Physical Therapy Presents Twelfth Annual Doctoral Project Presentation Day

The Global Strategy For Women's, Children's And Adolescents' Health (2016-2030): A Roadmap Based On Evidence And Country Experience., Shyama Kuruvilla, Flavia Bustreo, Taona Kuo, Marleen Temmerman

Obstetrics and Gynaecology, East Africa

The Global strategy for women’s, children’s and adolescents’ health (2016–2030) provides a roadmap for ending preventable deaths of women, children and adolescents by 2030 and helping them achieve their potential for and rights to health and well-being in all settings.1 The global strategy has three objectives: survive (end preventable deaths); thrive (ensure health and well-being); and transform (expand enabling environments). These objectives are aligned with 17 targets within nine of the sustainable development goals (SDGs),2 including SDG 3 on health and other SDGs related to the political, social, economic and environmental determinants of health and sustainable development.

Like the SDGs, …

Ifn-Γ Receptor And Stat1 Signaling In B Cells Are Central To Spontaneous Germinal Center Formation And Autoimmunity., Phillip P. Domeier, Sathi Babu Chodisetti, Chetna Soni, Stephanie L. Schell, Melinda J. Elias, Eric B. Wong, Timothy K. Cooper, Daisuke Kitamura, Ziaur S.M. Rahman

Department of Microbiology and Immunology Faculty Papers

Spontaneously developed germinal centers (GCs [Spt-GCs]) harbor autoreactive B cells that generate somatically mutated and class-switched pathogenic autoantibodies (auto-Abs) to promote autoimmunity. However, the mechanisms that regulate Spt-GC development are not clear. In this study, we report that B cell-intrinsic IFN-γ receptor (IFN-γR) and STAT1 signaling are required for Spt-GC and follicular T helper cell (Tfh cell) development. We further demonstrate that IFN-γR and STAT1 signaling control Spt-GC and Tfh cell formation by driving T-bet expression and IFN-γ production by B cells. Global or B cell-specific IFN-γR deficiency in autoimmune B6.Sle1b mice leads to significantly reduced Spt-GC and Tfh cell …

A Study Of Emotional Intelligence, Empathy And Burnout In Graduate And Post Graduate Medical Training At Lvhn, Amy B. Smith Phd, Jeanne L. Jacoby Md, Carmine Pellosie Do, Mph, Mba, Carolyn Lamparella Lpc

Department of Education

No abstract provided.

Impacts Of Environmental Quality On The Demographics Of Three Nations, Emily Hummel

Honors Projects

This study will examine how the correlation between air and water quality and the population demographics of India, South Africa, and the United States. India is a country with a growing population, increasing income inequality, and gender roles that reflect its status as a developing nation. South Africa is much smaller in area and the population is beginning to level off, but South Africa’s income inequality is growing much faster than India’s and gender inequality is less of an issue in South Africa. The population of the United States is decreasing and gender roles are fairly equal, despite income inequality …

Healthcare Leadership Institute, Jayna Clemens

Honors Projects

The Healthcare Leadership Institute is a program designed to offer high school sophomores an opportunity to develop leadership skills, a professional mentorship relationship, and a better understanding of the variety and diversity of professions in the healthcare field. The Healthcare Leadership Institute also includes a 10-day international immersion trip after the completion of the classroom curriculum. In total, the program lasts the duration of one academic year, with the 10-day immersion trip taking place at the beginning of summer break before they begin their junior year. The international immersion trip will not only allow the participants an opportunity to apply …

Acth Prevents Deficits In Fear Extinction Associated With Early Life Seizures, Andrew T. Massey, David K. Lerner, Gregory L. Holmes, Rod C. Scott, Amanda Hernan

Dartmouth Scholarship

Objective: Early life seizures (ELS) are often associated with cognitive and psychiatric comorbidities that are detrimental to quality of life. In a rat model of ELS, we explored long-term cognitive outcomes in adult rats. Using ACTH, an endogeneous HPA-axis hormone given to children with severe epilepsy, we sought to prevent cognitive deficits. Through comparisons with dexamethasone, we sought to dissociate the corticosteroid effects of ACTH from other potential mechanisms of action.

Results: Although rats with a history of ELS were able to acquire a conditioned fear learning paradigm and controls, these rats had significant deficits in their ability to extinguish …

Impact Of Emergency Department Sepsis Policy, Lynette Rayman

Evidence-Based Practice Project Reports

Sepsis is a serious concern of key healthcare stakeholders due to high incidence, mortality, and cost. The objectives of this evidence-based project were to 1) identify potential sepsis patients early during the emergency department (ED) triage process and 2) implement Sepsis Order Sets. Kotter’s change model and the Stetler model of evidence-based practice guided this project. An extensive literature search was undertaken to find best practice evidence regarding care of sepsis patients. Recommended care includes a protocolized format utilizing a screening tool and point of care lactate levels for early identification of sepsis, and early treatment with antibiotics and fluid …

The Effects Of Continuing Education On Nurse Knowledge Of Safe Haven Laws In Illinois, Lindsay Thiemkey Gordon

Evidence-Based Practice Project Reports

Illegal and often fatal infant abandonment is a pervasive public health crisis. Safe Haven Laws (SHLs) help to prevent illegal infant abandonment by allowing specific professionals, including nurses, to accept unharmed newborns within statutorily defined parameters. SHLs have existed for nearly two decades, yet many healthcare workers are not knowledgeable about these laws: this implies that initial efforts to educate healthcare workers about SHLs have been ineffective. Continuing education supports lifelong learning which is a basic tenet of nursing practice. The purpose of this evidence-based practice (EBP) project was to teach nurses about SHLs through evidence-based continuing education. Literature firmly …

Developing An Academic Portfolio For Initial Appointment And Promotion., John C. Smulian Md, Mph

Department of Obstetrics & Gynecology

No abstract provided.

The Effects Of Locomotion-Induced Shock Loading On Tibiofemoral Bone Stress Response, Alexa Standerfer, Suzenna Ngo, Karen Daun

UNLV Theses, Dissertations, Professional Papers, and Capstones

Purpose/Hypothesis: Knee osteoarthritis (Coats, Zioupos, & Aspden) is a degenerative joint disease that negatively impacts the quality of life. About 9.3 million people in the U.S. population are affected. It has been suggested via magnetic resonance imaging (MRI) studies that bone marrow edema (i.e., indicative of bone stress response) and joint structure changes may be the main contributing factors of pain in OA. Frontal plane lower extremity (LE) alignment has been a topic of much interest regarding development of OA in the knee joint. It is hypothesized that varus alignment increases forces through the medial compartment of the knee, thereby …

Investigating Metal Cations As Potential Inhibitors Of Iapp Aggregation: Kcl, Cacl2, And Cucl2, Megan Burke

Honors Thesis

IAPP is an amyloid protein that misfolds, causing toxic aggregation in the pancreas of Type II Diabetes patients. In this study, three metal cations (KCl, CaCl2, and CuCl2) are tested in Thioflavin T assays and atomic force microscopy (AFM) to see if they inhibit the aggregation of IAPP.

Management Of Type 1 Diabetes Perioperatively, Biye Gohla Tambang

Nursing Capstones

No abstract provided.

Interviewing Skills And Techniques, Elaine A. Donoghue Md, Amanda B. Flicker Md

Department of Education

No abstract provided.

Pessary Versus Cerclage Versus Expectant Management For Cervical Dilation With Visible Membranes In The Second Trimester., Alexis C. Gimovsky, Anju Suhag, Amanda Roman, Burton L. Rochelson, Vincenzo Berghella

Department of Obstetrics and Gynecology Faculty Papers

OBJECTIVE: We evaluated pessary for dilated cervix and exposed membranes for prolonging pregnancy compared to cerclage or expectant management.

METHODS: Multicenter retrospective cohort study of women, 15-24 weeks, singleton pregnancies, dilated cervix ≥2 cm and exposed membranes. Women received pessary, cerclage or expectant management. Primary outcome was gestational age (GA) at delivery. Secondary outcomes were time until delivery, preterm premature rupture of membranes (PPROM) and neonatal survival.

RESULTS: About 112 women met study criteria; 9 - pessary, 85 - cerclage and 18 - expectant management. Mean GA at delivery was 22.9 ± 4.5 weeks with pessary, 29.2 ± 7.5 weeks …

Hospital-Skilled Nursing Facility Referral Linkage Reduces Readmission Rates Among Medicare Patients Receiving Major Surgery, Andrew J. Schoenfeld, Xuan Zhang, David C. Grabowski, Vincent Mor, Joel S. Weissman, Momotazur Rahman

Research Collection School Of Economics

BACKGROUND:In the health reform era, rehospitalization after discharge may result in financial penalties to hospitals. The effect of increased hospital-skilled nursing facility (SNF) linkage on readmission reduction after surgery has not been explored.METHODS:To determine whether enhanced hospital-SNF linkage, as measured by the proportion of surgical patients referred from a hospital to a particular SNF, would result in reduced 30-day readmission rates for surgical patients, we used national Medicare data (2011-2012) and evaluated patients who underwent 1 of 5 operative procedures (coronary artery bypass grafting [CABG], hip fracture repair, total hip arthroplasty, colectomy, or lumbar spine surgery). Initial evaluation was performed …

Lasers In Tattoo And Pigmentation Control: Role Of The Picosure(®) Laser System., Richard Torbeck, Richard Bankowski, Sarah Henize, Nazanin Saedi

Department of Dermatology and Cutaneous Biology Faculty Papers

BACKGROUND AND OBJECTIVES: The use of picosecond lasers to remove tattoos has greatly improved due to the long-standing outcomes of nanosecond lasers, both clinically and histologically. The first aesthetic picosecond laser available for this use was the PicoSure(®) laser system (755/532 nm). Now that a vast amount of research on its use has been conducted, we performed a comprehensive review of the literature to validate the continued application of the PicoSure(®) laser system for tattoo removal.

STUDY DESIGN AND METHODS: A PubMed search was conducted using the term "picosecond" combined with "laser", "dermatology", and "laser tattoo removal".

RESULTS: A total …

Why Sepsis Diagnosis Is Missed In The Emergency Department, Elizabeth Nolan

Grace Peterson Nursing Research Colloquium

No abstract provided.

Building The Foundation: Utilizing Concept Maps To Enhance Critical Thinking In First Semester Nursing Students, Lisa S. Smith

Nursing Theses and Capstone Projects

Critical thinking and clinical decision making are essential components of the knowledge and skills necessary for all nurses in order to make complex decisions that improve patient outcomes, safety, and quality of nursing care. Promoting student competence in critical thinking skills is imperative for nurse educators. Concept mapping is an active teaching strategy that can assist nurse educators in preparing nursing students to think critically in today’s complex health care environment. The purpose of this project was to implement concept maps as an additional instructional activity with first semester Associate Degree Nursing (ADN) students to promote confidence in basic critical …

Post-Concussion Policy Change For The Student-Athlete, Heather Porter

Nursing Theses and Capstone Projects

The intent of the evidence-based practice project was to implement a policy change for the development and implementation of a policy and related procedures to ensure equity and continuity in practices for successful reintegration of student-athletes who had sustained a concussion back into their classrooms. The lack of attention on cognitive effects of concussion and the “ripple effect” in the classroom needed to be addressed by the nursing profession from an education-intervention focus. A corrective action plan was developed by a doctoral student including an educational teaching session and PowerPoint Presentation and pilot policy. The end result of the project …

Transitioning Novice Nurses To Expert Nurses In Progressive Telemetry Care, Timothy E. Fraley

Nursing Theses and Capstone Projects

New nurses do not possess the clinical skills necessary to thrive in a fast-paced, rapidly changing telemetry unit. The study explores the idea that nurses with less than two years’ experience may not have the self-confidence or experience to begin a career on a telemetry unit. A search of the literature was performed to identify the skills needed to be successful in a critical care telemetry unit. Established orientation programs, nurse internships, and nursing experience were the keywords researched. Patricia Benner’s Theory: From Novice to Expert Excellence and Power in Clinical Nursing Practice (1984) serves as the foundation for this …

Calpain-5 Expression In The Retina Localizes To Photoreceptor Synapses, Kellie A. Schaefer, Marcus A. Toral, Gabriel Velez, Allison J. Cox, Sheila A. Baker, Nicholas C. Borcherding, Diana F. Colgan, Vimala Bondada, Charles B. Mashburn, Chen Guang Yu, James W. Geddes, Stephen H. Tsang, Alexander G. Bassuk, Vinit B. Mahajan

Spinal Cord and Brain Injury Research Center Faculty Publications

Purpose: We characterize calpain-5 (CAPN5) expression in retinal and neuronal subcellular compartments.

Methods: CAPN5 gene variants were classified using the exome variant server, and RNA-sequencing was used to compare expression of CAPN5 mRNA in the mouse and human retina and in retinoblastoma cells. Expression of CAPN5 protein was ascertained in humans and mice in silico, in mouse retina by immunohistochemistry, and in neuronal cancer cell lines and fractionated central nervous system tissue extracts by Western analysis with eight antibodies targeting different CAPN5 regions.

Results: Most CAPN5 genetic variation occurs outside its protease core; and searches …

Providing Pediatric Patients With A Voice : Understanding How Children Want To Live Before They Die, Nina Friedman

Graduate Student Independent Studies

This paper explores what quality of life is for pediatric patients and how health care professionals, a certified child life specialist in particular, can help the patient, family, and medical team to navigate treatment options and decisions regarding end-of-life.

A Literature Review Of The Membership, Roles, And Processes Of Healthcare Ethics Committees, Benjamin P. Cain, Johnathan K. Nelson

Celebration of Student Scholarship Poster Sessions Archive

No abstract provided.