Medicine and Health Sciences Commons^™

Leveraging Smart Infusion Pump Data For Workflow, Patient Care And Usability Improvement In Human Factors, Yan Ni Ding, Denny Yu, Poching Delaurentis, Kang-Yu Hsu, Joon Hong Kim

The Summer Undergraduate Research Fellowship (SURF) Symposium

Infusion pumps are medical devices that deliver fluids like medication, and nutrients in a precise, timely, and controlled manner that is critical to patient care. It is widely used in clinical settings especially in hospitals, nursing homes and sometimes at home. Smart infusion pumps technology are supposed to be reduce nurses’ workload, but due to the recurring number of alarms which disrupt the workflow of the infusion process, most nurses prefer to use the traditional infusion pumps or work-around the safety features of the smart pumps. Thus, the aim of this research is to leverage Smart Infusion Pump data to …

Analyzing Sports Training Data With Machine Learning Techniques, Rehana Mahfuz, Zeinab Mourad, Aly El Gamal

The Summer Undergraduate Research Fellowship (SURF) Symposium

In the sports industry, there has not been enough effort in analyzing the personalized monitoring data of athletes collected during training sessions. This research is an attempt to find meaningful patterns in the Purdue Women’s Soccer training data that could help the coach design more efficient training sessions. We are specifically interested in studying this problem as an unsupervised learning problem. Our initial attempt is to cluster the players as well as drills into groups using k-means, c-means and spectral clustering algorithms, combined with feature transformation and reduction steps. These basic algorithms serve as a benchmark to measure performance improvements …

Characterization Of Left-Ventricular Thrombus Formation Using High Frequency Ultrasound, Kelsey A. Bullens, Arvin H. Soepriatna, Pavlos P. Vlachos, Craig J. Goergen

The Summer Undergraduate Research Fellowship (SURF) Symposium

Heart failure is a leading cause of death in the United States, and cardiac thrombus, a common morbidity associated with heart failure, significantly increases a patient’s risk of embolic events. The objective of this project is to characterize left-ventricular (LV) thrombus development using high frequency ultrasound imaging in a murine model. C57BL/6J wild-type mice (n=6) were injected intraperitoneally with iron dextran five times a week for six weeks to increase oxidative stress in the heart. Granulocyte-colony stimulating factor (G-CSF) was subcutaneously injected daily during the second week to initiate stem cell migration and stimulate endothelial cell activation, thus increasing the …

Ball Pressure Correlations With Peak Impact Force And The Potential For Cumulative Mtbi When Heading A Soccer Ball, Nicolas Leiva, Daniel Y. Shyu, Josh Auger, Eric Nauman

The Summer Undergraduate Research Fellowship (SURF) Symposium

Soccer is a unique sport in which athletes use their heads as tools for gameplay, which may ultimately cause cumulative traumatic brain injuries. Due to rising popularity of soccer in the United States alongside the increased occurrence of CTE and mTBI in other contact sports, there is a growing concern over how to keep the repetitive forces caused by heading, as low as possible. Different variables that can affect the peak force felt when heading a soccer ball can be simulated and compared with in-game data, however, this has never been properly tested before. In the present study two size …

Cartilage Engineering: Optimization Of Media For Chondrogenic Differentiation In Vitro, Evan Surma, Sherry L. Harbin, Hongji Zhang, Stacy Halum

The Summer Undergraduate Research Fellowship (SURF) Symposium

Lower back pain from intervertebral disc injury affects around 84% of the population at some point in their life, which at its worst may cause total immobilization. This pain can only be temporarily relieved by spinal fusion or intervertebral disc replacement; however, both of these cause loss of natural motion in patients by removing damaged fibrocartilage discs. While these techniques help mitigate pain briefly, no permanent solution exists currently to both relieve pain and preserve natural motion. My work may be a solution by eventually providing patient-specific implants that resemble native tissue in the regeneration process that could be absorbed …

Mechanical Reliability Of Implantable Polyimide-Based Magnetic Microactuators For Biofouling Removal, Christian G. Figueroa-Espada, Qi Yang, Hyowon Lee

The Summer Undergraduate Research Fellowship (SURF) Symposium

Hydrocephalus is a neurological disorder that typically requires a long-term implantation of a shunt system to manage its symptoms. These shunt systems are notorious for their extremely high failure rate. More than 40% of all implanted shunt systems fail within the first year of implantation. On average, 85% of all hydrocephalus patients with shunt systems undergo at least two shunt-revision surgeries within 10 years of implantation. A large portion of this high failure rate can be attributed to biofouling-related obstructions and infections. Previously, we developed flexible polyimide-based magnetic microactuators to remove obstructions formed on hydrocephalus shunts. To test the long-term …

Development Of Standard Criteria To Evaluate The Effectiveness Of Helmets At Decreasing The Risk Of Concussions, Daniel Y. Shyu, Goutham N. Sankaran, Kevin G. Mciver, Nicolas Leiva, Eric A. Nauman

The Summer Undergraduate Research Fellowship (SURF) Symposium

In many sports, such as American football, accumulations of mild traumatic brain injuries have been suggested as a possible link to neurodegeneration and future mental disorders. With head impacts occurring at all levels of competition and in different sports, it is critical to develop an accurate method for quantifying the effects of head impacts and determining the efficacy of helmets. This study examines the derivation of different dimensionless numbers and ascertains the critical factors needed to predict the effects of head impacts, specifically the resulting accelerations from an impact. Given a known force of impact, parameters such as peak translation …

Assembly Of Nucleic Acid-Based Nanoparticles By Gas-Liquid Segmented Flow Microfluidics, Matthew L. Capek, Ross Verheul, David H. Thompson

The Summer Undergraduate Research Fellowship (SURF) Symposium

The development of novel and efficient mixing methods is important for optimizing the efficiency of many biological and chemical processes. Tuning the physical and performance properties of nucleic acid-based nanoparticles is one such example known to be strongly affected by mixing efficiency. The characteristics of DNA nanoparticles (such as size, polydispersity, ζ-potential, and gel shift) are important to ensure their therapeutic potency, and new methods to optimize these characteristics are of significant importance to achieve the highest efficacy. In the present study, a simple segmented flow microfluidics system has been developed to augment mixing of pDNA/bPEI nanoparticles. This DNA and …

The Causal Relevance Of Body Mass Index In Different Histological Types Of Lung Cancer: A Mendelian Randomization Study, Robert Carreras-Torres, Philip C. Haycock, Caroline L. Relton, Richard M. Martin, George Davey Smith, Peter Kraft, Chi Gao, Shelley Tworoger, Loic Le Marchand, Lynne R. Wilkens, Sungshim L. Park, Christopher Haiman, John K. Field, Michael Davies, Mihcael Marcus, Geoffrey Liu, Neil E. Caporaso, David C. Christiani, Yongyue Wei, Chu Chen, Jennifer A. Doherty, Gianluca Severi, Gary E. Goodman, Rayjean J. Hung, Christopher I. I. Amos, James Mckay, Mattias Johansson, Paul Brennan

Dartmouth Scholarship

Body mass index (BMI) is inversely associated with lung cancer risk in observational studies, even though it increases the risk of several other cancers, which could indicate confounding by tobacco smoking or reverse causality. We used the two-sample Mendelian randomization (MR) approach to circumvent these limitations of observational epidemiology by constructing a genetic instrument for BMI, based on results from the GIANT consortium, which was evaluated in relation to lung cancer risk using GWAS results on 16,572 lung cancer cases and 21,480 controls. Results were stratified by histological subtype, smoking status and sex. An increase of one standard deviation (SD) …

The Genetic Architecture Of Type 2 Diabetes, Christian Fuchsberger, Jason Flannick, Tanya M. Teslovich, Anubha Mahajan, Vineeta Agarwala, Kyle J. Gaulton, Joanne E. Curran, Satish Kumar, John Blangero, Ravi Duggirala

School of Medicine Publications

The genetic architecture of common traits, including the number, frequency, and effect sizes of inherited variants that contribute to individual risk, has been long debated. Genome-wide association studies have identified scores of common variants associated with type 2 diabetes, but in aggregate, these explain only a fraction of heritability. To test the hypothesis that lower-frequency variants explain much of the remainder, the GoT2D and T2D-GENES consortia performed whole genome sequencing in 2,657 Europeans with and without diabetes, and exome sequencing in a total of 12,940 subjects from five ancestral groups. To increase statistical power, we expanded sample size via genotyping …

The Airway Microbiome At Birth., Charitharth Vivek Lal, Colm Travers, Zubair H. Aghai, Peter Eipers, Tamas Jilling, Brian Halloran, Waldemar A. Carlo, Jordan Keeley, Gabriel Rezonzew, Ranjit Kumar, Casey Morrow, Vineet Bhandari, Namasivayam Ambalavanan

Department of Pediatrics Faculty Papers

Alterations of pulmonary microbiome have been recognized in multiple respiratory disorders. It is critically important to ascertain if an airway microbiome exists at birth and if so, whether it is associated with subsequent lung disease. We found an established diverse and similar airway microbiome at birth in both preterm and term infants, which was more diverse and different from that of older preterm infants with established chronic lung disease (bronchopulmonary dysplasia). Consistent temporal dysbiotic changes in the airway microbiome were seen from birth to the development of bronchopulmonary dysplasia in extremely preterm infants. Genus Lactobacillus was decreased at birth in …

A Matter Of Degrees? Views Of Ems Online Degrees' Value And Design, Sandy Hunter

EKU Faculty and Staff Scholarship

EMS has continued its move from a product of training to being the result of education. A part of that process has been the proliferation of academic programs that focus upon emergency medical services related topical areas. As this trend continues, it is incumbent upon the educators who teach these curricula to determine the most desired and (therefore) effective designs for EMS degrees. This presentation will discuss the results of statewide online research of Paramedics in Kentucky, asking several questions to determine: - the current level of education among that population, - the types of EMS programs they completed, - …

The Right For Autonomy, The Duty Of Disclosure And Public Health Considerations – The 2013 Polio Crisis In Israel As A Case Study, Dr. Nili Karako Eyal

Pace Law Review

Despite sharing the same theoretical framework of discussion with other papers, this paper addresses an ethical and legal issue that has received little attention in academic and public discourse: the duty of disclosure in the context of vaccinations. In particular, the paper addresses the question whether public health considerations provide a justification for restricting the duty of disclosure in the case of vaccination.

Delimitating the research question to the issue of disclosure has several implications. First, the decision to vaccinate the population with bOPV as describe above and the decision to adopt a voluntary vaccination policy are not the focus …

Avoiding Overtreatment At The End Of Life: Physician-Patient Communication And Truly Informed Consent, Barbara A. Noah, Neal R. Feigenson

Pace Law Review

This paper’s primary focus will be on considering how best to ensure that patients have the tools to make both informed and authentic choices about their care at the end of life. We will argue that truly informed decision making can help to reduce excessive end-of-life care by any measure. Most importantly for dying patients, better informed decisions can help reduce unnecessary suffering and result in care that aligns with their well-considered values and preferences.

In the first part of this paper, we will explain that, by any of these measures, many dying patients are receiving too much therapy and …

Primary Health Care: Potential Home For Family-Focused Preventive Interventions, Laurel K Leslie, Christopher J Mehus, J David Hawkins, Thomas Boat, Mary Ann Mccabe, Shari Barkin, Ellen C Perrin, Carol W Metzler, And 4 Others

Pediatrics Faculty Publications

Family-focused prevention programs have been shown to effectively reduce a range of negative behavioral health outcomes but have had limited reach. Three key barriers must be overcome to expand the reach of family-focused prevention programs and thereby achieve a significant public health impact. These barriers are (1) current social norms and perceptions of parenting programs; (2) concerns about the expertise and legitimacy of sponsoring organizations to offer parenting advice; and (3) a paucity of stable, sustainable funding mechanisms. Primary healthcare settings are well positioned to overcome these barriers. Recent changes within health care make primary care settings an increasingly favorable …

A Rare Association Of Giant Cell Arteritis With Recurrent Corneal Ulcer, Sailaja Bondalapati, Kay Khine, Maya Bitar, David Chesnutt, Richard M. Davis

Ophthalmology

We report a rare case of association of temporal arteritis with recurrent central corneal ulcer. A 91-year-old male with a remote history of clinically diagnosed giant cell arteritis (GCA) and penetrating keratoplasty (PK) for corneal edema in 1990’s in the left eye presented with irritation and severe dry eye. He progressively developed central corneal ulcer regardless of treatment with aggressive lubrication and patching. The clinical course, blood tests and temporal artery biopsy results yielded the diagnosis of recurrent GCA. The clinical course improved after starting oral steroids. The case report illustrates the importance of ruling out GCA in patients with …

A Trial-By-Trial Window Into Sensorimotor Transformations In The Human Motor Periphery., Chao Gu, Daniel K Wood, Paul L Gribble, Brian D Corneil

Brain and Mind Institute Researchers' Publications

UNLABELLED: The appearance of a novel visual stimulus generates a rapid stimulus-locked response (SLR) in the motor periphery within 100 ms of stimulus onset. Here, we recorded SLRs from an upper limb muscle while humans reached toward (pro-reach) or away (anti-reach) from a visual stimulus. The SLR on anti-reaches encoded the location of the visual stimulus rather than the movement goal. Further, SLR magnitude was attenuated when subjects reached away from rather than toward the visual stimulus. Remarkably, SLR magnitudes also correlated with reaction times on both pro-reaches and anti-reaches, but did so in opposite ways: larger SLRs preceded shorter …

Activated Clotting Time (Act): Comparison Of The Hemochron Signature Elite And The Abbott I-Stat, Lilah Evans, Susanne Gallo, Joseph J. Leo, Barbara Goldsmith, Phd, Facb

Department of Pathology, Anatomy, and Cell Biology Posters

BACKGROUND

ACT is commonly used for heparin anticoagulation monitoring during procedures including cardiopulmonary bypass surgery, coronary angioplasty, and interventional radiology. To prevent thrombosis, moderate to high levels of heparin anticoagulation are required. The Hemochron Signature Elite (HSE, Accriva Diagnostics, formerly ITC, San Diego, CA) was implemented at TJUH as a replacement for the older model Hemochron Response (Accriva/ITC Model HRS.110, San Diego, CA). Operating room (OR) perfusionists reported irreproducible high results using HSE that could not be explained clinically. In consideration of use of i-STAT analyzers (Abbott Point of Care, Princeton, NJ) as an alternative to HSE, we performed a …

Performance Of Creatinine And Chloride On The Epoc Analyzer, Lilah Evans, Susanne Gallo, Stacey K. Mardekian, Barbara Goldsmith, Phd, Facb

Department of Pathology, Anatomy, and Cell Biology Posters

BACKGROUND

The epoc Blood Analysis System (Alere, Orlando, FL) performs blood gases, electrolytes, and metabolites using a Blood Gas Electrolyte and Metabolite (BGEM) Test Card panel on 92 uL of whole blood. The BGEM test card uses potentiometric sensors to measure sodium, potassium, ionized calcium, pH, pCO2; amperometric sensors to measure pO2, glucose, and lactate; and a conductometric sensor to measure hematocrit. Results are available in 3-10 minutes, depending upon the time between calibration and patient testing. TJUH implemented the epoc in its ICUs in 2012 to provide Point of Care (POC) results. Alere recently added creatinine and chloride sensors …

Predominant Expression Of Alzheimer’S Disease-Associated Bin1 In Mature Oligodendrocytes And Localization To White Matter Tracts, Pierre De Rossi, Virginie Buggia-Prévot, Benjamin L. L. Clayton, Jared B. Vasquez, Carson Van Sanford, Robert J. Andrew, Ruben Lesnick, Alexandra Botté, Carole Deyts, Someya Salem, Eshaan Rao, Richard C. Rice, Angèle Parent, Satyabrata Kar, Brian Popko, Peter Pytel, Steven Estus, Gopal Thinakaran

Physiology Faculty Publications

Background: Genome-wide association studies have identified BIN1 within the second most significant susceptibility locus in late-onset Alzheimer’s disease (AD). BIN1 undergoes complex alternative splicing to generate multiple isoforms with diverse functions in multiple cellular processes including endocytosis and membrane remodeling. An increase in BIN1 expression in AD and an interaction between BIN1 and Tau have been reported. However, disparate descriptions of BIN1 expression and localization in the brain previously reported in the literature and the lack of clarity on brain BIN1 isoforms present formidable challenges to our understanding of how genetic variants in BIN1 increase the risk for AD.

Methods: …

Novel Somatic Copy Number Alteration Identified For Cervical Cancer In The Mexican American Population, Alireza Torabi, Javier Ordonez, Brenda Bin Su, Laura Palmer, Chunxiang Mao, Katherine E. Lara, Lewis P. Rubin, Chun Xu

Health & Biomedical Sciences Faculty Publications

Cervical cancer affects millions of Americans, but the rate for cervical cancer in the Mexican American is approximately twice that for non-Mexican Americans. The etiologies of cervical cancer are still not fully understood. A number of somatic mutations, including several copy number alterations (CNAs), have been identified in the pathogenesis of cervical carcinomas in non-Mexican Americans. Thus, the purpose of this study was to investigate CNAs in association with cervical cancer in the Mexican American population. We conducted a pilot study of genome-wide CNA analysis using 2.5 million markers in four diagnostic groups: reference (n = 125), low grade dysplasia …

An Excursion Into The Creative Process: An Artistic Inquiry Utlizing Ritualistic Self-Care In Movement, Bobbi Jean Mckissick

Creative Arts Therapies Theses

The purpose of this artistic inquiry self-study was to explore my experience of the creative process. This purpose stemmed from the concept that it is not enough to believe that I am creative, but I wanted to know how and why. During this study, I was a 33 year-old multiethnic, middle-class female, who had been raised in a foster home on the East Coast. I was living in Chicago, Illinois as a graduate student at Columbia College Chicago for a master’s degree in Dance/Movement Therapy and Counseling. The research questions presented were: How does ritualistic self-care promote availability into my …

The Pathophysiology Of Alpha-1 Antitrypsin Deficiency And Copd, Melissa M. Miller

Nursing Student Class Projects (Formerly MSN)

Chronic obstructive pulmonary disease (COPD) is the number one disease process treated in the Pulmonary Department at the Chalmers P. Wylie VA Ambulatory Care Center (VAACC). The medical staff includes doctors, nurses, and respiratory therapists. The team works together to ensure the veteran gets the best care available. Smoking is very popular in the military, and this puts veterans at a higher risk for COPD, compared to the general public. COPD can develop at a much younger age if the patient has alpha-1 antitrypsin deficiency (AATD). Janciauskiene, Ferrotti, Laenger, Jonigk, and Luisetti (2011) point out that patients who develop COPD …

Systemic Lupus Erythematosus: Cardiovascular Pathophysiology, Jennifer L. Mullins

Nursing Student Class Projects (Formerly MSN)

Systemic lupus erythematosus (SLE) is an autoimmune disease implicated in the premature onset of cardiovascular disease. SLE`s chronic activation of the immune system leads to inflammation, obstruction and vascular damage. The damage is most pronounced in SLE patients with a sedentary lifestyle and early onset of the disease. Understanding the pathogenesis, signs and symptoms of how SLE affects the cardiovascular system is important. Nurse practitioners play a vital role in the implementation of strategies to manage care and improve outcomes.

Systemic Lupus Erythematosus: Cardiovascular Pathophysiology, Jennifer L. Mullins

Nursing Student Class Projects (Formerly MSN)

Systemic lupus erythematosus (SLE) is an autoimmune disease implicated in the premature onset of cardiovascular disease. SLE`s chronic activation of the immune system leads to inflammation, obstruction and vascular damage. The damage is most pronounced in SLE patients with a sedentary lifestyle and early onset of the disease. Understanding the pathogenesis, signs and symptoms of how SLE affects the cardiovascular system is important. Nurse practitioners play a vital role in the implementation of strategies to manage care and improve outcomes.

Surveillance, Epidemiological, And Virological Detection Of Highly Pathogenic H5n1 Avian Influenza Viruses In Duck And Poultry From Bangladesh, Wahedul Karim Ansari, Md Safiullah Parvej, Mohamed E. El Zowalaty, Sally Jackson, Stephen A. Bustin, Adel K. Ibrahim, Md Tanvir Rahman, Han Zhang, Mohammad Ferdousur Rahman Khan, Md Mostakin Ahamd, Md. Fasiur Rahman, Marzia Rahman, Khm Nazmul H. Nazir, Sultan Ahmed, Md Liakot Hossenn, Md Abdul Kafi, Mat Yamage, Nitish C. Debnath, Graba Ahmed, Hossam Ashour, Md Masoud, Ayman Noreddin, Md B. Rahman

Pharmacy Faculty Articles and Research

Avian influenza viruses (AIVs) continue to pose a global threat. Waterfowl are the main reservoir and are responsible for the spillover of AIVs to other hosts. This study was conducted as part of routine surveillance activities in Bangladesh and it reports on the serological and molecular detection of H5N1 AIV subtype. A total of 2169 cloacal and 2191 oropharyngeal swabs as well as 1725 sera samples were collected from live birds including duck and chicken in different locations in Bangladesh between the years of 2013 and 2014. Samples were tested using virus isolation, serological tests and molecular methods of RT-PCR. …

Amidated Dopamine Neuron Stimulating Peptide Restoration Of Mitochondrial Activity, Luke H. Bradley, Don M. Gash, Greg A. Gerhardt

Neuroscience Faculty Patents

The present invention relates to the use of novel proteins, referred to herein as amidated glial cell line-derived neurotrophic factor (GDNF) peptides (or “Amidated Dopamine Neuron Stimulating peptides (ADNS peptides)”), for treating brain diseases and injuries that result in dopaminergic deficiencies and mitochodrial dysfunction, e.g., reduced complex I enzyme activity.

Mapping An Epitope In Ebna-1 That Is Recognized By Monoclonal Antibodies To Ebna-1 That Cross-React With Dsdna, Pragya Yadav, Matthew T. Carr, Ruby Yu, Alice Mumbey-Wafula, Linda Spatz

Publications and Research

Introduction: The Epstein Barr Virus (EBV) has been associated with the autoimmune disease, Systemic Lupus Erythematosus (SLE). EBV nuclear antigen-I (EBNA-1) is the major nuclear protein of EBV. We previously generated an IgG monoclonal antibody (MAb) to EBNA-1, 3D4, and demonstrated that it crossreacts with double stranded DNA (dsDNA) and binds the 148 amino acid viral binding site (VBS) in the carboxyl region of EBNA-1. The aim of the present study was to characterize another antibody to EBNA-1 that cross-reacts with dsDNA, compare its immunoglobulin genes to 3D4, and finely map the epitope in EBNA-1 that is recognized by these …

Understanding Neighborhood Satisfaction For Individuals With Psychiatric Disabilities: A Mixed Methods Study, Amy Leigh Shearer

Dissertations and Theses

Physical and social characteristics of neighborhoods are important to resident satisfaction for clinical and nonclinical populations. This study draws upon data collected from a sample of 172 individuals with psychiatric disabilities living in 16 supportive housing sites in the Portland, Oregon metropolitan area. Research questions explore the extent to which subjective and objective measures of neighborhood physical and social environments contribute to neighborhood satisfaction for this population. Mixed methods were employed to construct a detailed understanding of the factors that influence satisfaction with one's neighborhood of residence. Predictor variables were neighborhood social climate, neighborhood physical quality, perceptions of safety, crime …

Engaging An Outpatient Adult With Depression In Shared Decision-Making To Improve Outcomes, Twila J. Mursu

Nursing Capstones

No abstract provided.