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What's Happening: August 8, 2016, Maine Medical Center

What's Happening

No abstract provided.

Advanced Practice Nursing In Latin America And The Caribbean: Regulation, Education And Practice, Keri Elizabeth Zug, Silvia Helena De Bortoli Cassiani, Joyce Pulcini, Alessandra Bassalobre Garcia, Francisca Aguirre-Boza, Jeongyoung Park

Nursing Faculty Publications

OBJECTIVE: to identify the current state of advanced practice nursing regulation, education and practice in Latin America and the Caribbean and the perception of nursing leaders in the region toward an advanced practice nursing role in primary health care to support Universal Access to Health and Universal Health Coverage initiatives.

METHOD: a descriptive cross-sectional design utilizing a web-based survey of 173 nursing leaders about their perceptions of the state of nursing practice and potential development of advanced practice nursing in their countries, including definition, work environment, regulation, education, nursing practice, nursing culture, and perceived receptiveness to an expanded role in …

Mitochondrial Akt Regulation Of Hypoxic Tumor Reprogramming., Young Chan Chae, Valentina Vaira, M. Cecilia Caino, Hsin-Yao Tang, Jae Ho Seo, Andrew V. Kossenkov, Luisa Ottobrini, Cristina Martelli, Giovanni Lucignani, Irene Bertolini, Marco Locatelli, Kelly G. Bryant, Jagadish C. Ghosh, Sofia Lisanti, Bonsu Ku, Silvano Bosari, Lucia R. Languino, David W. Speicher, Dario C. Altieri

Department of Cancer Biology Faculty Papers

Hypoxia is a universal driver of aggressive tumor behavior, but the underlying mechanisms are not completely understood. Using a phosphoproteomics screen, we now show that active Akt accumulates in the mitochondria during hypoxia and phosphorylates pyruvate dehydrogenase kinase 1 (PDK1) on Thr346 to inactivate the pyruvate dehydrogenase complex. In turn, this pathway switches tumor metabolism toward glycolysis, antagonizes apoptosis and autophagy, dampens oxidative stress, and maintains tumor cell proliferation in the face of severe hypoxia. Mitochondrial Akt-PDK1 signaling correlates with unfavorable prognostic markers and shorter survival in glioma patients and may provide an "actionable" therapeutic target in cancer.

Infant And Young Child Feeding Practices Differ By Ethnicity Of Vietnamese Mothers, Tuan T. Nguyen, Phuong H. Nguyen, Nemat Hajeebhoy, Huan V. Nguyen, Edward A. Frongillo Jr.

Faculty Publications

Background: Limited studies have examined ethnic variation in breastfeeding and complementary feeding practices in developing countries. This study investigated ethnic variation in feeding practices in mothers with children 0–23 months old in Vietnam.

Methods: We used data on 1875 women who came from the ethnic majority, Kinh (n = 989, randomly sampled from 9875 surveyed Kinh mothers, 10 % from each province) and three ethnic minorities: E De-Mnong (n = 309), Thai-Muong (n = 229) and Tay-Nung (n = 348). Ethnic minorities were compared with the Kinh group using logistic regression model.

Results: Prevalence of breastfeeding initiation within an hour …

Case Study Of Persons With Cancer Participating In A Community-Based Exercise Program: An Exploration Of Meaning And Change, Barbara K. Haas, Melinda Hermanns, Christina Melin-Johansson

Nursing Faculty Publications and Presentations

Increasingly, research supports the importance of incorporating exercise into the cancer care paradigm. While quantitative studies have substantiated the significant effects of exercise on physical functioning, the individual’s perspective of participating in an exercise program has rarely been considered. The purpose of this study was to explain the impact of a community based exercise program on the lives of persons with cancer and their caregivers. Based on Bandura’s Social Cognitive Theory, a single explanatory case study with multiple embedded units of analyses was conducted. Interviews were conducted with 10 individuals representing participants with cancer, their caregivers, and health care providers. …

Inhibiting Androgen Receptor Nuclear Entry In Castration-Resistant Prostate Cancer, Julie A. Pollock, Suzanne E. Wardell, Alexander A. Parent, David B. Stagg, Stephanie J. Ellison, Holly M. Alley, Christina A. Chao, Scott A. Lawrence, James P. Stice, Ivan Spasojevic, Jennifer G. Baker, Sung Hoon Kim, Donald P. Mcdonnell, John A. Katzenellenbogen, John D. Norris

Chemistry Faculty Publications

Clinical resistance to the second-generation antiandrogen enzalutamide in castration resistant prostate cancer (CRPC), despite persistent androgen receptor (AR) activity in tumors, highlights the unmet medical need for next generation antagonists. We have identified and characterized tetra-aryl cyclobutanes (CBs) as a new class of competitive AR antagonists that exhibit a unique mechanism of action. These CBs are structurally distinct from current antiandrogens (hydroxyflutamide, bicalutamide, and enzalutamide), and inhibit AR-mediated gene expression, cell proliferation, and tumor growth in several models of CRPC. Conformational profiling revealed that CBs stabilize an AR conformation resembling an unliganded receptor. Using a variety of techniques, it was …

Week Of August 8, 2016, New York Medical College

InTouch

• NYMC Welcomes SOM Class of 2020
• Andrew Mutnick, M.D. '01, Is Named SOM Associate Dean for Student Affairs
• SOM Office of Admissions Seeks MMI Interviewers
• SOM Offers High School Students Hands-On Look at Medicine

Case Study Of Persons With Cancer Participating In A Community-Based Exercise Program: An Exploration Of Meaning And Change, Barbara K. Haas, Melinda Hermanns, Christina Melin-Johansson

The Qualitative Report

Increasingly, research supports the importance of incorporating exercise into the cancer care paradigm. While quantitative studies have substantiated the significant effects of exercise on physical functioning, the individual’s perspective of participating in an exercise program has rarely been considered. The purpose of this study was to explain the impact of a community based exercise program on the lives of persons with cancer and their caregivers. Based on Bandura’s Social Cognitive Theory, a single explanatory case study with multiple embedded units of analyses was conducted. Interviews were conducted with 10 individuals representing participants with cancer, their caregivers, and health care providers. …

Medical School Watercooler Newsletter - August 7, 2016, Lindsey Lyle

Watercooler Newsletter

This is the August 7, 2016 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents Include:

• USA Mourns Loss of Dr. Herbert H. Winkler
• USA Welcomes Dr. Elizabeth Park
• Dr. Brooks Cash Quoted in TIME Magazine
• South Alabama Pediatricians, Family Physicians, Hospital Administrators Announce Local Impact of Medicaid Cut

Lumbar Lateral Shift In A Patient With Interspinous Device Implantation: A Case Report, Seth Peterson, Cheri Hodges

PT Faculty Publications

Background:Lumbar lateral shift (LLS) is a common clinical observation but has rarely been described in a patient with a history of lumbar surgery. The purpose of the current case report was to describe the use of the McKenzie Method of Mechanical Diagnosis and Therapy (MDT) in the multi-modal treatment of a patient with an LLS and a history of multiple surgical procedures in the lumbar spine, including interspinous process device (IPD) implantation. Case description:A 72-year-old female with chronic low back pain (LBP) and a surgical history in the lumbar spine was referred to physical therapy for radiating leg pain and …

Agenda (Pdf), Lsu Health Sciences Center - New Orleans

Usher Syndrome in Louisiana

Agenda for the Usher Syndrome in Louisiana 2nd Symposium held August 6, 2016.

Improving Veteran Access To Heart Failure Specialty Care: A Change Model Project, Mark Bird Whelchel

Dissertations

Background: Many Veterans Health Administration (VHA) facilities have cardiac services, but not all VHA centers offer heart failure care. Viable alternative models exist to traditional outpatient treatment by physicians, such as Tele-medicine consultations, the use of nurse practitioner run clinics, and the use of models such as Specialty Care Access Network-Extension for Community (SCAN-ECHO) and site specific contracted physician services models. These have the potential to improve Veteran access to care. Objective: The purpose of this change project was to conduct a needs assessment survey, in joint effort with the Hershey Medical Center Heart and Vascular Institute, to identify barriers …

What And How Do Students Learn In An Interprofessional Student-Run Clinic? An Educational Framework For Team-Based Care, Désirée A. Lie, Christopher Forest, Anne Walsh, Yvonne Banzali, Kevin Lohenry

Physician Assistant Studies Faculty Articles and Research

Background: The student-run clinic (SRC) has the potential to address interprofessional learning among health professions students.

Purpose: To derive a framework for understanding student learning during team-based care provided in an interprofessional SRC serving underserved patients.

Methods: The authors recruited students for a focus group study by purposive sampling and snowballing. They constructed two sets of semi-structured questions for uniprofessional and multiprofessional groups. Sessions were audiotaped, and transcripts were independently coded and adjudicated. Major themes about learning content and processes were extracted. Grounded theory was followed after data synthesis and interpretation to establish a framework for interprofessional …

Binge Ethanol Exposure Causes Endoplasmic Reticulum Stress, Oxidative Stress And Tissue Injury In The Pancreas, Zhenhua Ren, Xin Wang, Mei Xu, Fanmuyi Yang, Jacqueline A. Frank, Zun-Ji Ke, Jia Luo

Pharmacology and Nutritional Sciences Faculty Publications

Alcohol abuse is associated with both acute and chronic pancreatitis. Repeated episodes of acute pancreatitis or pancreatic injury may result in chronic pancreatitis. We investigated ethanol-induced pancreatic injury using a mouse model of binge ethanol exposure. Male C57BL/6 mice were exposed to ethanol intragastrically (5 g/kg, 25% ethanol w/v) daily for 10 days. Binge ethanol exposure caused pathological changes in pancreas demonstrated by tissue edema, acinar atrophy and moderate fibrosis. Ethanol caused both apoptotic and necrotic cell death which was demonstrated by the increase in active caspase-3, caspase-8, cleaved PARP, cleaved CK-18 and the secretion of high mobility group protein …

Implementing A Pain Toolkit To Improve Pain Management, Kathleen R. Atkins Dnp, Mary J. Dyck Phd, Nancy L. Novotny Phd, Karen S. Delong Msn

Theses and Dissertations

Abstract

OBJECTIVES: The purpose of this study was to evaluate the effect of a pain toolkit to improve pain management.

BACKGROUND: The World Health Organization and Joint Commission state effective pain management is a basic human right.

METHODS: Patients’ ratings of pain management on a 25-bed orthopedic/neurology unit three months before and after implementation of a toolkit were compared. The toolkit included bedside report, care board, purposeful hourly rounding, pain algorithm, pain status indicator, and complex pain interventions. The data are comprised of patient responses to the following Hospital Consumer Assessment of Healthcare Providers and Systems survey questions: pain control …

Blinatumomab May Induce Graft Versus Host Leukemia In Patients With Pre-B All Relapsing After Hematopoietic Stem Cell Transplant, Muhammad Waqas Khan, Zartash Gul

Internal Medicine Faculty Publications

Blinatumomab, a bispecific T-cell engager monoclonal antibody used to manage Philadelphia chromosome-negative relapsed or refractory B-cell precursor acute lymphoblastic leukemia (ALL) can be used to treat patients by inducing graft versus leukemia reaction post allogeneic hematopoietic stem cell transplantation, a feature which it was post allogeneic bone marrow transplantation, a feature which this drug was not aimed to do.

College Of Public Health News, Georgia Southern University

College of Public Health: News & Publications

• Georgia Southern Examines Social Network Characteristics
• Georgia Southern Estimates for Cell Counts and Common Odds Ratio

Inactivation Of Type I Ifn Jak-Stat Pathway In Ebv Latency, Shunbin Ning, Ling Wang

ETSU Faculty Works

Epstein-Barr Virus (EBV) latent infection is associated with a variety of lymphomas and carcinomas. Interferon (IFN) Regulatory Factors (IRFs) are a family of transcription factors, among which IRF7 is the “master” regulator of type I IFNs (IFN-I) that defends against invading viruses. Robust IFN-I responses require a positive feedback loop between IRF7 and IFN-I. In recent years, we have discovered that IRF7 is significantly induced and activated by the principal EBV oncoprotein--Latent Membrane Protein 1 (LMP1); however, IRF7 fails to trigger robust IFN-I responses in EBV latency. We believe this intriguing finding is critical for EBV latency and oncogenesis, yet …

A Primate Apol1 Variant That Kills Trypanosoma Brucei Gambiense, Anneli Cooper, Paul Capewell, Caroline Clucas, Nicola Veitch, William Weir, Russell Thompson, Jayne Raper, Annette Macleod

Publications and Research

Humans are protected against infection from most African trypanosomes by lipoprotein complexes present in serum that contain the trypanolytic pore-forming protein, Apolipoprotein L1 (APOL1). The human-infective trypanosomes, Trypanosoma brucei rhodesiense in East Africa and T. b. gambiense in West Africa have separately evolved mechanisms that allow them to resist APOL1-mediated lysis and cause human African trypanosomiasis, or sleeping sickness, in man. Recently, APOL1 variants were identified from a subset of Old World monkeys, that are able to lyse East African T. b. rhodesiense, by virtue of C-terminal polymorphisms in the APOL1 protein that hinder that parasite’s resistance mechanism. Such variants …

Health Policy & Management News, Georgia Southern University

Health Policy & Community Health: News & Publications (2011-2018)

• Georgia Southern Examines Social Network Characteristics

Ischemic Strokes, Jada Adams

Nursing Student Class Projects (Formerly MSN)

Stroke or cerebrovascular accident (CVA) is the third leading cause of death in the United States (Mvundura, McGruder, Khoury, Valdez, & Yoon, 2011). Ischemic strokes make up about 86% of the strokes that occur, (Patel, & White, 2011) hemorrhagic and cryptogenic strokes make up for the other 15%. The topic that is covered in this poster is ischemic stroke. The biggest way to alter the amount of strokes that happen are to prevent them. More and more risk factors are being found that contribute to strokes. Once the inflammatory and immune response begins once triggered by hypoxia it cannot be …

Pseudocholinesterase Deficiency: Implications In Anesthesia, Amanda Esselstein

Nursing Student Class Projects (Formerly MSN)

Pseudocholinesterase is an enzyme produced in the liver that metabolizes neuromuscular blocking agents, particularly succinylcholine. A deficiency in pseudocholinesterase is typically caused by either a homozygous or heterozygous abnormal genetic variant of the enzyme which leads to a prolonged neuromuscular block and therefore muscle paralysis. It is vital for anesthesia providers to know the mechanism of action and duration of succinylcholine, as well as appropriate assessment and treatment if a pseucholinesterase deficiency is suspected. There is no treatment for a pseudocholinesterase deficiency of a genetic origin, however supportive care, particularly ventilator support, must be provided until the medication has been …

Essential Hypertension In Adults, Elizabeth Oti

Nursing Student Class Projects (Formerly MSN)

The author chose to write about hypertension because she takes care of patients and family members with hypertension on a frequent basis, and is likely to face the challenge of managing patients with hypertension (HTN) in her future role as a nurse practitioner due to the high prevalence of HTN among men and women.

Effects Of Pediatric Emergence Delirium Education On Analgesic Administration By Pacu Nurses, Melinda C. Nwanganga

Evidence-Based Practice Project Reports

Emergence delirium (ED) is a behavioral disturbance as a result of general anesthesia that commonly occurs in pediatric patients. Adverse effects of ED lead to a complicated recovery from anesthesia due to the risk of self-inflicted injury of patients, the disturbance of surgical incisions, the development of postoperative maladaptive behaviors, and the increased use of sedatives and analgesics resulting in prolonged recovery time and delayed discharge from the post-anesthesia care unit (PACU). Due to the multiple ramifications of ED, appropriate care is needed to promote a safe recovery from anesthesia and an optimum perioperative experience for these patients. As PACU …

Real-Time Temperature And Heat Flux Measurements For Lyophilization Process Design And Monitoring: Part 1, Evan T. Liechty, Nicholas J. Huls, Andrew D. Strongrich, Alina A. Alexeenko

The Summer Undergraduate Research Fellowship (SURF) Symposium

Lyophilization is a common method used to preserve pharmaceutical and biological products. Accurately measuring temperature during the three stages of lyophilization: freezing, primary drying, and secondary drying, is important to ensure product consistency and to reduce operating costs. Wireless temperature sensors were evaluated to determine if temperature is monitored accurately and to determine if wireless temperature sensors offer advantages over traditional temperature measurement technologies. These sensors contain three capacitors to monitor temperature as the solvent is sublimated. A Millrock Technology REVO lyophilizer was used for testing. Water and 5% w/v sucrose solution were distributed in 3 mL fill volume increments …

Analyzing Mutations Of Spt7 Protein That Disrupt Interaction With Sf3b Subunits, Arryn T. Harris, Peyton J. Spreacker, Rachel Stegeman, Vikki M. Weake, Edwin C. Acosta

The Summer Undergraduate Research Fellowship (SURF) Symposium

Proper transcription, the process of converting DNA to RNA, is crucial for the health and viability of an organism. This process is regulated by many proteins, such as co-transcriptional activators; one being the protein complex known as Spt-Ada-Gcn5-acetyltransferase, or SAGA. While much is known about the roles of SAGA in cell processes, how SAGA’s subunits promote functionality is still unknown. The focus of this study is to analyze the purpose of SAGA’s SF3B subunits. These subunits are also found in the spliceosome, the compound responsible for generating mature RNA. SAGA has no known functions relating to this process, so the …

Design And Development Of A Plasmid Vector For Protein Expression And Purification, Mahima Grover, Craig Sweet, David H. Thompson

The Summer Undergraduate Research Fellowship (SURF) Symposium

Production and isolation of proteins are difficult, costly and time-consuming processes. The aim of this project is for the development of plasmids, which allow for streamlined production and isolation of proteins. To allow for modular insertion of varying segments of DNA we are using ‘recursive directional ligation by plasmid reconstruction’. This technique uses type II restriction endonucleases, which cut downstream from their recognition site allowing multiple insertions without losing a restriction site. Using this process, we can ligate multiple DNA sequences together and express them to be able to construct a scar less fusion protein. In order to accomplish this, …

The Role Of Osteocyte Estrogen Receptor Beta (Erβ) In Regulating The Skeletal Response To Mechanical Loading, Julia P. Townsend, Russell P. Main

The Summer Undergraduate Research Fellowship (SURF) Symposium

Estrogen’s biological functions are mediated by estrogen binding to estrogen receptors (ER). Understanding what role both ERα and ERβ have in bone maintenance and formation can contribute to possible treatment of osteoporosis. This study examined osteocyte specific deletion of ERβ in mice. The cross of ERβ-floxed mice with DMP1-8kb-Cre mice provided both experimental knockout mice as well as littermate control mice. At 24 weeks of age the left tibiae of all mice were mechanically loaded five days per week for two weeks to induce bone formation. Analysis of cortical bone was conducted using microcomputed tomography (microCT) to measure load-induced changes …

Pathway By Which Vagus Nerve Stimulation Of B Fibers Affects Heart Rate, Kelsey Wasilczuk, Matthew Ward, Pedro Irazoqui

The Summer Undergraduate Research Fellowship (SURF) Symposium

Heart failure (HF) affects over 5 million adults in the United States. Many HF patients have a high resting heart rate, which is correlated with a high mortality rate. In recent years, vagus nerve stimulation (VNS) has become an increasingly researched therapy to reduce the resting heart rate of HF patients. However, current dosage given during VNS is increased incrementally at the doctor’s office until side effects present themselves in a patient. In addition, the means by which the therapy works is not completely understood. To better understand the therapy’s mechanisms, the right cervical vagus nerve of several Long Evans …

Nanobubbles Provide Theranostic Relief To Cancer Hypoxia, Christopher M. Long, Pushpak N. Bhandari, Joseph Irudayaraj

The Summer Undergraduate Research Fellowship (SURF) Symposium

Hypoxia is a common motif among tumors, contributing to metastasis, angiogenesis, cellular epigenetic abnormality, and resistance to cancer therapy. Hypoxia also plays a pivotal role in oncological studies, where it can be used as a principal target for new anti-cancer therapeutic methods. Oxygen nanobubbles were designed in an effort to target the hypoxic tumor regions, thus interrupting the hypoxia-inducible factor-1α (HIF-1α) regulatory pathway and inhibiting tumor progression. At less than 100nm, oxygen nanobubbles act as a vehicle for site-specific oxygen delivery, while also serving as an ultrasound contrast agent for advanced imaging purposes. Through in vitro and in vivo studies, …