Medicine and Health Sciences Commons^™

Relationship Science And Interventions: Where We Are And Where We Are Going, Kieran T. Sullivan, Erika E. Lawrence

Psychology

Relationship distress and divorce often have profound effects on couples and their children. Relationship science has long sought to prevent and alleviate relationship distress; this chapter is a summary of many important recent developments in the field. Ongoing challenges in studying and assisting intimate relationships are also discussed.

Microangiopathic Occlusion Of A Perforating Prepontine Long Circumferential Artery Presenting With Lower Motor Neuron Facial Weakness: Clinical And Radiological Correlation, Archie Defillo Md, Muhammad Shah Miran Md, Kenneth Shea Md, Michelle Peterson Np, Leah Roering Np, Jerone Kennedy Md, M. Fareed, K. Suri

Articles

Case Description: A 79-year old male patient with myelodysplastic syndrome associated with severe neutropenia, thrombocytopenia, anemia, hypertension, and hyperlipidemia was admitted for pneumonia secondary to influenza A. Two weeks later he presented with new symptoms of acute dysarthria, and left facial weakness involving his upper and lower face; the following day he developed left arm weakness. Admission computed tomography (CT) and MRI scans revealed an acute ischemic stroke (AIS) in the right posterior frontal cortex. The initial MRI was reported negative for pontine lesions. Anatomically, the cortical infarct could not explain his left lower motor neuron cranial nerve VII (LMN …

Opportunities And Challenges In Incorporating Ancillary Studies Into A Cancer Prevention Randomized Clinical Trial, Phyllis J. Goodman, Catherine M. Tangen, Amy K. Darke, Kathryn B. Arnold, Joann Hartline, Monica Yee, Karen Anderson, Allison Caban-Holt, William G. Christen, Patricia A Cassano, Peter Lance, Eric A. Klein, John J. Crowley, Lori M. Minasian, Frank L. Meyskens

Sanders-Brown Center on Aging Faculty Publications

Background: The Selenium and Vitamin E Cancer Prevention Trial (SELECT) was a randomized, double-blind, placebo-controlled, prostate cancer prevention study funded by the National Cancer Institute and conducted by SWOG (Southwest Oncology Group). A total of 35,533 men were assigned randomly to one of four treatment groups (vitamin E + placebo, selenium + placebo, vitamin E + selenium, placebo + placebo). At the time of the trial’s development, NIH had invested substantial resources in evaluating the potential benefits of these antioxidants. To capitalize on the knowledge gained from following a large cohort of healthy, aging males on the effects of selenium …

Does Tailoring Instructional Style To A Medical Student's Self-Perceived Learning Style Improve Performance When Teaching Intravenous Catheter Placement? A Randomized Controlled Study., Dimitrios Papanagnou, Antonio Serrano, Kaitlyn Barkley, Shruti Chandra, Nicholas Governatori, Nicole Piela, Gregory K. Wanner, Richard Shin

Department of Emergency Medicine Faculty Papers

BACKGROUND: Students may have different learning styles. It is unclear, however, whether tailoring instructional methods for a student's preferred learning style improves educational outcomes when teaching procedures. The authors sought to examine whether teaching to a student's self-perceived learning style improved the acquisition of intravenous (IV) catheter placement skills. The authors hypothesized that matching a medical student's preferred learning style with the instructor's teaching style would increase the success of placing an IV catheter.

METHODS: Using the VARK model (i.e., visual [V], auditory [A], read/write [R] and kinesthetic [K]), third-year medical students reported their self-perceived learning style and were subsequently …

Variation In Physician Practice Styles Within And Across Emergency Departments, Jessica Van Parys

Publications and Research

Despite the significant responsibility that physicians have in healthcare delivery, we know surprisingly little about why physician practice styles vary within or across institutions. Estimating variation in physician practice styles is complicated by the fact that patients are rarely randomly assigned to physicians. This paper uses the quasi-random assignment of patients to physicians in emergency departments (EDs) to show how physicians vary in their treatment of patients with minor injuries. The results reveal a considerable degree of variation in practice styles within EDs; physicians at the 75th percentile of the spending distribution spend 20% more than physicians at the 25th …

Gold Nanostars For Efficient In Vitro And In Vivo Real-Time Sers Detection And Drug Delivery Via Plasmonic-Tunable Raman/Ftir Imaging, Furong Tian, Joao Conde, Chenchen Bao, Yunsheng Chen, James Curtin, Daxiang Cui

Articles

The application of plasmonic-enhanced Raman imaging of cancer cells and drug delivery is gaining momentum. Here, we propose a new theranostic strategy based on an efficient plasmonic-tunable Raman/Fourier transform infrared (FTIR) spectroscopy imaging, to simultaneously evaluate the anticancer drug scattering cellular imaging and the Raman scattering molecular vibration signals in living cells. This technique allows to monitoring the drug release throughout the cell cycle and in vivo biodistribution and biocompatibility with low dose drug therapy (200 µg/mL) and low toxicity effect. This system can directly track in real-time the delivery and release of an anticancer drug (mitoxantrone, MTX) from gold …

Implementation Of The Affordable Care Act In Physical Therapy, Greg Austin

Mahurin Honors College Capstone Experience/Thesis Projects

Introduction: With the implementation of the Affordable Care Act (ACA) in 2010, many medical specialties prepared to see reimbursement rates altered. Not impervious to this trend was the field of physical therapy (PT). This change in reimbursement structure could impact the effectiveness of PT treatment. Under this model, a patient may not be able to receive the appropriate number of visits to a physical therapist, resulting in a loss of utilization in the injured area and, possibly, a loss of independence. Methods: A literature review was performed to determine reimbursement rate impact on PT. A seven-item open-ended survey regarding various …

Parental Sensitivity Predicted By Parent Personality And Infant Temperament, Lauren Bailes

Mahurin Honors College Capstone Experience/Thesis Projects

The determinants of parenting model (Belsky, 1984) suggests that there are intrinsic and extrinsic factors that contribute to parenting. Previous research has suggested that aspects of parent personality, such as neuroticism and extraversion, were predictive of parenting, but this research has provided conflicting results on the effect personality has on parenting. Furthermore, infant temperament has also found to be influential on parenting, but has also generated mixed results concerning how negative reactivity influences parenting. In regard to both variables, research on fathers is severely lacking. This study examined the direct effects of parent personality on parenting through the BIS/BAS model. …

Tumor-Associated Stromal Cells As Key Contributors To The Tumor Microenvironment., Karen M. Bussard, Lysette Mutkus, Kristina Stumpf, Candelaria Gomez-Manzano, Frank C. Marini

Department of Cancer Biology Faculty Papers

The tumor microenvironment is a heterogeneous population of cells consisting of the tumor bulk plus supporting cells. It is becoming increasingly evident that these supporting cells are recruited by cancer cells from nearby endogenous host stroma and promote events such as tumor angiogenesis, proliferation, invasion, and metastasis, as well as mediate mechanisms of therapeutic resistance. In addition, recruited stromal cells range in type and include vascular endothelial cells, pericytes, adipocytes, fibroblasts, and bone-marrow mesenchymal stromal cells. During normal wound healing and inflammatory processes, local stromal cells change their phenotype to become that of reactive stroma. Under certain conditions, however, tumor …

Pcom Opportunities Academy 2016 Graduation Ceremony, Pcom Office Of Diversity And Community Relations

Diversity and Inclusion

Program for PCOM Opportunities Academy Graduation Ceremony, Inagural Class.

Master of Ceremonies: Meghan Cleghorn, JH, MBA, President of Cleghorn Performance Elevation LLC.

Keynote Speaker: Antonia Novello, MD, 14th Surgeon General of the United States.

Rnai Nanotechnology: A Platform For Sirna Screening And Cancer Gene Therapy, Mayurbhai Ravikant Patel

Seton Hall University Dissertations and Theses (ETDs)

Over the past two decades, advances in RNA structural biology have improved our understanding of the structures and folding properties of naturally occurring RNAs. RNA sequences and structures participate in many specific biological functions, such as those performed by messenger RNA (mRNA), ribosomal RNA (rRNA), transfer RNA (tRNA), micro RNA (miRNA), short-interfering RNA (siRNA), small nuclear RNA (snRNA) and many others. The noncoding RNAs, such as siRNA, do not express proteins but have been utilized in a wide range of applications, including RNA interference (RNAi) and the regulation of mRNA expression. These important biological functions have been implemented in gene …

A New Paradigm: Group Medical Appointments For Individuals With Diabetes Using Insulin Pumps, Kathleen Brown, Cynthia Payonk

Patient Care Services / Nursing

No abstract provided.

The Role Of Physician's Assistants On Limiting The Risk Of Surgical Errors, Courtney Adler

Honors Theses

Surgical errors existed long before physician assistants (PA) starting joining surgical teams. However, the addition of PAs to surgical teams added a team member with a medical perspective that was different from everyone else’s. PAs are able to follow surgical patients through all the steps of the surgical process. This allows them to have a deeper knowledge of the patient’s case, putting them in a position to promote a culture of safety and reduce the risk of surgical errors. This study generates an idea of how the PA plays a role in lowering the risk of surgical errors by promoting …

Ptsd Symptom Severities, Interpersonal Traumas, And Benzodiazepines Are Associated With Substance-Related Problems In Trauma Patients, Jeffrey Guina, Ramzi W. Nahhas, Adam J. Goldberg, Seth Farnsworth

Population and Public Health Sciences Faculty Publications

Background: Trauma is commonly associated with substance-related problems, yet associations between specific substances and specific posttraumatic stress disorder symptoms (PTSSs) are understudied. We hypothesized that substance-related problems are associated with PTSS severities, interpersonal traumas, and benzodiazepine prescriptions. Methods: Using a cross-sectional survey methodology in a consecutive sample of adult outpatients with trauma histories (n = 472), we used logistic regression to examine substance-related problems in general (primary, confirmatory analysis), as well as alcohol, tobacco, and illicit drug problems specifically (secondary, exploratory analyses) in relation to demographics, trauma type, PTSSs, and benzodiazepine prescriptions. Results: After adjusting for multiple testing, several factors …

Health & Kinesiology News, Georgia Southern University

Health Sciences & Kinesiology: News & Publications (2015-2023)

• CHHS Faculty Invited to Speak and Instruct at USA Basketball Youth Coach Academy

Dance-Based Exercise Therapy For People With Arthritis: An Update And Commentary, Ray Marks

Publications and Research

No abstract provided.

Evaluation Of Microparticulate Ovarian Cancer Vaccine Via Transdermal Route Of Delivery, Suprita A. Tawde, Lipika Chablani, Archana Akalkotkar, Martin J. D'Souza

Pharmacy Faculty/Staff Publications

Ovarian cancer is the fifth most commonly occurring malignancy in women, with the highest mortality rate among all the gynecological tumors. Microparticulate vaccine can serve as an immunotherapeutic approach with a promising antigenic delivery system without a need for conventional adjuvants. In this study, a microparticulate vaccine using whole cell lysate of a murine ovarian cancer cell line, ID8 was prepared by spray drying. Further, the effect of interleukins (ILs) such as IL-2 and IL-12 was evaluated in a separate study group by administering them with vaccine particles to enhance the immune response. The vaccine microparticles were administered to C57BL/6 …

Quef And Quef-Like: Diverse Chemistries In A Common Fold, Adriana Bon Ramos

Dissertations and Theses

The tunneling fold (T-Fold) superfamily is a small superfamily of enzymes found in organisms encompassing all kingdoms of life. Seven members have been identified thus far. Despite sharing a common three-dimensional structure these enzymes perform very diverse chemistries.

QueF is a bacterial NADPH-dependent oxidoreductase that catalyzes the reduction of the nitrile group of 7-cyano-7-deazaguanine (preQ₀) to a primary amine (preQ₁) in the queuosine biosynthetic pathway. Previous work on this enzyme has revealed the mechanism of reaction but the cofactor binding residues remain unknown. The experiments discussed herein aim to elucidate the role of residues lysine 80, …

The Impact Of Nutrition And Physical Activity Education On The Knowledge, Attitude, And Behavior Of Muslim Youth From Various Ethnic Backgrounds, Hana L. Jaber, Zainab Rida

UCARE: Research Products

The Islamic Foundation of Lincoln is a growing population within Lincoln including many different racial backgrounds, ethnic identities, and languages. Due to these various backgrounds communication may impair the education of families as well as their attitudes and behaviors. Although there are programs developed for many other minority groups, the Muslim (population comprising the Islamic Foundation of Lincoln) population does not have any data obtained from the community in terms of nutrition and physical activity behaviors, attitudes, and knowledge. This study seeks to understand if there are barriers to communication and if the intervention enhanced nutrition knowledge. This poster reflects …

Spatial Attention To Social Cues Is Not A Monolithic Process, Samuel M. Harding, Ty W. Boyer, Bennett I. Bertenthal

Psychology: Faculty Presentations (2009-2022)

Social stimuli are a highly salient source of information, and seem to possess unique qualities that set them apart from other well-known categories. One characteristic is their ability to elicit spatial orienting, whereby directional stimuli like eyegaze and pointing gestures act as exogenous cues that trigger automatic shifts of attention that are difficult to inhibit. This effect has been extended to non-social stimuli, like arrows, leading to some uncertainty regarding whether spatial orienting is specialized for social cues. Using a standard spatial cueing paradigm, we found evidence that both a pointing hand and arrow are effective cues, but that the …

Comprehensive Audiometric Analysis Of Hearing Impairment And Tinnitus After Cisplatin-Based Chemotherapy In Survivors Of Adult-Onset Cancer., Robert D. Frisina, Heather E. Wheeler, Sophie D. Fossa, Sarah L. Kerns, Chunkit Fung, Howard D. Sesso, Patrick O. Monahan, Darren R. Feldman, Robert Hamilton, David J. Vaughn, Clair J. Beard, Amy Budnick, Eileen M. Johnson, Shirin Ardeshir-Rouhani-Fard, Lawrence H. Einhorn, Steven E. Lipshultz, M. Eileen Dolan, Lois B. Travis

Bioinformatics Faculty Publications

PURPOSE:

Cisplatin is widely used but highly ototoxic. Effects of cumulative cisplatin dose on hearing loss have not been comprehensively evaluated in survivors of adult-onset cancer.

PATIENTS AND METHODS:

Comprehensive audiological measures were conducted on 488 North American male germ cell tumor (GCT) survivors in relation to cumulative cisplatin dose, including audiograms (0.25 to 12 kHz), tests of middle ear function, and tinnitus. American Speech-Language-Hearing Association criteria defined hearing loss severity. The geometric mean of hearing thresholds (0.25 to 12 kHz) summarized overall hearing status consistent with audiometric guidelines. Patients were sorted into quartiles of hearing thresholds of age- and …

Schizophrenia Relapse, Patient Considerations, And Potential Role Of Lurasidone, Leslie L. Citrome

NYMC Faculty Publications

When treating persons with schizophrenia, delaying time to relapse is a main goal. Antipsychotic medication has been the primary treatment approach, and there are a variety of different choices available. Lurasidone is a second-generation (atypical) antipsychotic agent that is approved for the treatment of schizophrenia and bipolar depression. Three long-term studies of lurasidone have examined time to relapse in persons with schizophrenia, including a classic placebo-controlled randomized withdrawal study and two 12-month active comparator studies (vs risperidone and vs quetiapine extended-release). Lurasidone 40-80 mg/d evidenced superiority over placebo (number needed to treat [NNT] vs placebo for relapse, 9). Lurasidone 40-160 …

Dietetic Students Place First And Second In Poster Competition, College Of Education And Human Development

Family and Consumer Sciences News

Two groups of senior dietetic students presented posters at the Annual Conference of Michigan Academy of Nutrition and Dietetics held in Lansing at the end of April.

Dietary And Physical Activity Acculturation And Weight Status In Chinese College Students, Yanni Zhang

Dissertations and Theses

This cross-sectional study examined the relationships between length of residence in the United States (U.S.) and dietary and physical activity acculturation, and the relationships between dietary and physical activity acculturation and weight status in 55 Chinese college students. Length of residence in the U.S. was positively associated with larger portion size, greater amount of physical activity, and change in BMI in male participants. Adoption of a Western diet was associated with weight gain. Portion size change was positively associated with BMI change. Lunch size change was positively correlated with BMI change in males while negatively correlated with BMI change in …

Closed-State Inactivation Involving An Internal Gate In Kv4.1 Channels Modulates Pore Blockade By Intracellular Quaternary Ammonium Ions., Jeffrey D. Fineberg, Tibor G. Szanto, Gyorgy Panyi, Manuel Covarrubias

Department of Neuroscience Faculty Papers

Voltage-gated K(+) (Kv) channel activation depends on interactions between voltage sensors and an intracellular activation gate that controls access to a central pore cavity. Here, we hypothesize that this gate is additionally responsible for closed-state inactivation (CSI) in Kv4.x channels. These Kv channels undergo CSI by a mechanism that is still poorly understood. To test the hypothesis, we deduced the state of the Kv4.1 channel intracellular gate by exploiting the trap-door paradigm of pore blockade by internally applied quaternary ammonium (QA) ions exhibiting slow blocking kinetics and high-affinity for a blocking site. We found that inactivation gating seemingly traps benzyl-tributylammonium …

Glucan Phosphatase Variants For Starch Phosphorylation, Matthew S. Gentry, Craig Vander Kooi

Molecular and Cellular Biochemistry Faculty Patents

Glucan phosphatase nucleotide or polypeptide variants of the presently-disclosed subject matter can alter the biophysical properties of starch in vitro or in planta, as well as the total starch biomass production in planta as compared to plants expressing wild-type glucan phosphatases. Plants producing the polypeptide variants of the presently-disclosed subject matter can have increased starch accumulation, increased starched biomass, and/or starch having desired biophysical properties. A method of the presently-disclosed subject matter for producing altered starch includes providing a plant that produces a glucan phosphatase polypeptide variant that comprises an amino acid mutation and collecting starch from the plant.

Prophylactic Bacteriophage Administration More Effective Than Post-Infection Administration In Reducing Salmonella Enterica Serovar Enteritidis Shedding In Quail, Mosab Ahmadi, M. Amir Karimi Torshizi, Shaban Rahimi, John J. Dennehy

Publications and Research

Infections caused by Salmonella bacteria, often through poultry products, are a serious public health issue. Because of drawbacks associated with antibiotic prophylaxis, alternative treatments are sought. Bacterial viruses (bacteriophages) may provide an effective alternative, but concerns remain with respect to bacteriophage stability and effectiveness. To this end, we assessed the stability of a novel bacteriophage isolated from poultry excreta, siphovirus PSE, and its effectiveness in reducing Salmonella enterica serovar Enteritidis colonization in vitro and in vivo. Moreover, we sought to determine how the timing (prophylactic or therapeutic) and route (oral gavage or vent lip) of PSE administration impacted its effectiveness. …

An Evaluation Of The Relationship Between Core Endurance And Lower Extremity Strength, And The Ability To Recover After Perturbation, Carlie Jones-Hershinow

Ursidae: The Undergraduate Research Journal at the University of Northern Colorado

Previous research suggests core strength training improves anticipatory postural adjustments, reducing one’s risk of a fall, and stronger core muscles lead to faster reaction times. This study investigated whether core endurance and lower extremity strength relate to the time one needs to stabilize after being perturbed. An evaluation of ten participants while warming up determined each participant’s transition speed between walking and running. While each participant walked at his/her transition speed, the belts were stopped randomly at an acceleration rate of

2.7 m∙s^-2 and ground reaction forces were recorded during balance recovery. Additionally, each participant completed a series of …

Diabetic Kidney Disease, Karen R. Hughes Dr

Nursing Student Class Projects (Formerly MSN)

A poster project on Diabetic Kidney Disease (DKD) formerly known as diabetic nephropathy which is the most common cause of end-stage renal disease (ESRD) and death in patient with diabetes.

Ada News - 08/08/2016, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.